Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine phosphatase activity	PTPRD PTPRF PTPRK	1.46e-05	17	57	3	GO:0005001
GeneOntologyMolecularFunction	transmembrane receptor protein phosphatase activity	PTPRD PTPRF PTPRK	1.46e-05	17	57	3	GO:0019198
GeneOntologyMolecularFunction	protein tyrosine phosphatase activity	PTPN11 PTPRD PTPRF PTPRK	2.14e-04	103	57	4	GO:0004725
GeneOntologyCellularComponent	host cell part	GBP6 GBP1	1.09e-04	6	57	2	GO:0033643
GeneOntologyCellularComponent	host intracellular part	GBP6 GBP1	1.09e-04	6	57	2	GO:0033646
GeneOntologyCellularComponent	host cell cytoplasm part	GBP6 GBP1	1.09e-04	6	57	2	GO:0033655
GeneOntologyCellularComponent	symbiont-containing vacuole	GBP6 GBP1	1.09e-04	6	57	2	GO:0020003
GeneOntologyCellularComponent	symbiont-containing vacuole membrane	GBP6 GBP1	1.09e-04	6	57	2	GO:0020005
GeneOntologyCellularComponent	host intracellular region	GBP6 GBP1	1.09e-04	6	57	2	GO:0043656
GeneOntologyCellularComponent	host cell cytoplasm	GBP6 GBP1	1.09e-04	6	57	2	GO:0030430
GeneOntologyCellularComponent	host cellular component	GBP6 GBP1	7.50e-04	15	57	2	GO:0018995
HumanPheno	Superior pectus carinatum	PTPN11 BRAF	7.05e-05	4	18	2	HP:0000917
HumanPheno	Neurofibrosarcoma	PTPN11 BRAF	7.05e-05	4	18	2	HP:0100697
HumanPheno	Spondylolysis	FLNB CTSK	1.75e-04	6	18	2	HP:0003304
HumanPheno	Pectus excavatum of inferior sternum	PTPN11 BRAF	1.75e-04	6	18	2	HP:0000915
HumanPheno	Reduced factor XIII activity	PTPN11 BRAF	1.75e-04	6	18	2	HP:0008357
HumanPheno	Amegakaryocytic thrombocytopenia	PTPN11 BRAF	1.75e-04	6	18	2	HP:0004859
HumanPheno	Reduced factor XII activity	PTPN11 BRAF	1.75e-04	6	18	2	HP:0004841
Domain	PTPc	PTPN11 PTPRD PTPRF PTPRK	4.27e-06	36	57	4	SM00194
Domain	TYR_PHOSPHATASE_PTP	PTPN11 PTPRD PTPRF PTPRK	5.92e-06	39	57	4	PS50055
Domain	PTPase_domain	PTPN11 PTPRD PTPRF PTPRK	7.26e-06	41	57	4	IPR000242
Domain	Y_phosphatase	PTPN11 PTPRD PTPRF PTPRK	7.26e-06	41	57	4	PF00102
Domain	PTPc_motif	PTPN11 PTPRD PTPRF PTPRK	3.13e-05	59	57	4	SM00404
Domain	Tyr_Pase_cat	PTPN11 PTPRD PTPRF PTPRK	3.13e-05	59	57	4	IPR003595
Domain	Tyr_Pase_AS	PTPN11 PTPRD PTPRF PTPRK	7.25e-05	73	57	4	IPR016130
Domain	TYR_PHOSPHATASE_1	PTPN11 PTPRD PTPRF PTPRK	1.37e-04	86	57	4	PS00383
Domain	TYR_PHOSPHATASE_2	PTPN11 PTPRD PTPRF PTPRK	1.44e-04	87	57	4	PS50056
Domain	TYR_PHOSPHATASE_dom	PTPN11 PTPRD PTPRF PTPRK	1.44e-04	87	57	4	IPR000387
Domain	-	PTPN11 PTPRD PTPRF PTPRK	1.78e-04	92	57	4	3.90.190.10
Domain	Prot-tyrosine_phosphatase-like	PTPN11 PTPRD PTPRF PTPRK	2.37e-04	99	57	4	IPR029021
Domain	GBP_C	GBP6 GBP1	4.05e-04	10	57	2	PF02841
Domain	G_GB1_RHD3_dom	GBP6 GBP1	4.94e-04	11	57	2	IPR030386
Domain	Guanylate-bd_C	GBP6 GBP1	4.94e-04	11	57	2	IPR003191
Domain	GBP	GBP6 GBP1	4.94e-04	11	57	2	PF02263
Domain	Guanylate-bd_N	GBP6 GBP1	4.94e-04	11	57	2	IPR015894
Domain	G_GB1_RHD3	GBP6 GBP1	4.94e-04	11	57	2	PS51715
Domain	IMPORTIN_B_NT	IPO7 XPO1	8.13e-04	14	57	2	PS50166
Domain	IBN_N	IPO7 XPO1	9.37e-04	15	57	2	PF03810
Domain	IBN_N	IPO7 XPO1	1.07e-03	16	57	2	SM00913
Domain	Importin-beta_N	IPO7 XPO1	1.21e-03	17	57	2	IPR001494
Domain	ARM-type_fold	IPO7 NBEAL1 XPO1 ARMCX2 PUM1	3.70e-03	339	57	5	IPR016024
Domain	FN3_dom	IFNGR1 PTPRD PTPRF PTPRK	3.79e-03	209	57	4	IPR003961
Domain	-	IPO7 XPO1 ARMCX2 PUM1	4.69e-03	222	57	4	1.25.10.10
Pathway	WP_PILOCYTIC_ASTROCYTOMA	PTPN11 BRAF	1.29e-04	6	42	2	M39584
Pathway	REACTOME_INTERFERON_SIGNALING	IFNGR1 FLNB PTPN11 GBP6 GBP1 MX1	1.46e-04	273	42	6	M983
Pathway	WP_TYPE_II_INTERFERON_SIGNALING	IFNGR1 PTPN11 GBP1	1.78e-04	37	42	3	M39363
Pathway	REACTOME_INTERFERON_GAMMA_SIGNALING	IFNGR1 PTPN11 GBP6 GBP1	2.01e-04	98	42	4	M965
Pubmed	Protein tyrosine phosphatases expression during development of mouse superior colliculus.	PTPN11 PTPRD PTPRF PTPRK	1.52e-08	17	57	4	19727691
Pubmed	Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow.	PTPN11 PTPRF PTPRK	2.30e-06	16	57	3	8875997
Pubmed	Global proteomic assessment of the classical protein-tyrosine phosphatome and "Redoxome".	PTPN11 PTPRD	2.64e-06	2	57	2	21884940
Pubmed	Congenital polyvalvular disease expands the cardiac phenotype of the RASopathies.	PTPN11 BRAF	2.64e-06	2	57	2	33683002
Pubmed	The mouse gene Ptprf encoding the leukocyte common antigen-related molecule LAR: cloning, characterization, and chromosomal localization.	PTPRD PTPRF	2.64e-06	2	57	2	7665159
Pubmed	Interferon-gamma-dependent tyrosine phosphorylation of MEKK4 via Pyk2 is regulated by annexin II and SHP2 in keratinocytes.	PTPN11 MAP3K4	2.64e-06	2	57	2	15601262
Pubmed	Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis.	IPO7 XPO1	2.64e-06	2	57	2	22284678
Pubmed	Prognostic prediction of BRAF(V600E) and its relationship with sodium iodide symporter in classic variant of papillary thyroid carcinomas.	SLC5A5 BRAF	2.64e-06	2	57	2	23163107
Pubmed	Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway.	IFNGR1 PTPN11	2.64e-06	2	57	2	10022928
Pubmed	Clinical characteristics, surgical approach, BRAFV600E mutation and sodium iodine symporter expression in pediatric patients with thyroid carcinoma.	SLC5A5 BRAF	2.64e-06	2	57	2	33031052
Pubmed	T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice.	IFNGR1 PTPN11	2.64e-06	2	57	2	27935860
Pubmed	Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation.	RASIP1 FLNB IPO7 XPO1	6.14e-06	72	57	4	36376293
Pubmed	The tyrosine phosphatase Shp-2 confers resistance to colonic inflammation by driving goblet cell function and crypt regeneration.	PTPN11 BRAF	7.91e-06	3	57	2	30376595
Pubmed	MUC1-C is necessary for SHP2 activation and BRAF inhibitor resistance in BRAF(V600E) mutant colorectal cancer.	PTPN11 BRAF	7.91e-06	3	57	2	36878307
Pubmed	B-RafV600E inhibits sodium iodide symporter expression via regulation of DNA methyltransferase 1.	SLC5A5 BRAF	7.91e-06	3	57	2	25378232
Pubmed	Depletion of macrophages in mice results in higher dengue virus titers and highlights the role of macrophages for virus control.	IFNGR1 PTPN11	7.91e-06	3	57	2	19637226
Pubmed	BRAFV600E mutation, but not RET/PTC rearrangements, is correlated with a lower expression of both thyroperoxidase and sodium iodide symporter genes in papillary thyroid cancer.	SLC5A5 BRAF	7.91e-06	3	57	2	18509003
Pubmed	LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses.	PTPRD PTPRF	7.91e-06	3	57	2	31985401
Pubmed	Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation.	PTPRD PTPRF	7.91e-06	3	57	2	20139422
Pubmed	Chondroitin Sulfate Proteoglycans Negatively Modulate Spinal Cord Neural Precursor Cells by Signaling Through LAR and RPTPσ and Modulation of the Rho/ROCK Pathway.	PTPRD PTPRF	7.91e-06	3	57	2	25703008
Pubmed	Developmental expression of the cell adhesion molecule-like protein tyrosine phosphatases LAR, RPTPdelta and RPTPsigma in the mouse.	PTPRD PTPRF	7.91e-06	3	57	2	9784606
Pubmed	Intact synapse structure and function after combined knockout of PTPδ, PTPσ, and LAR.	PTPRD PTPRF	7.91e-06	3	57	2	33656439
Pubmed	NGS testing for cardiomyopathy: Utility of adding RASopathy-associated genes.	PTPN11 BRAF	7.91e-06	3	57	2	29696744
Pubmed	Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling.	PTPN11 CTSK	7.91e-06	3	57	2	23863940
Pubmed	Effects of germline mutations in the Ras/MAPK signaling pathway on adaptive behavior: cardiofaciocutaneous syndrome and Noonan syndrome.	PTPN11 BRAF	7.91e-06	3	57	2	20186801
Pubmed	SHP2 regulates osteoclastogenesis by promoting preosteoclast fusion.	PTPN11 CTSK	7.91e-06	3	57	2	25593124
Pubmed	Craniosynostosis in patients with RASopathies: Accumulating clinical evidence for expanding the phenotype.	PTPN11 BRAF	7.91e-06	3	57	2	28650561
Pubmed	Glycogen synthase kinase-3beta facilitates IFN-gamma-induced STAT1 activation by regulating Src homology-2 domain-containing phosphatase 2.	IFNGR1 PTPN11	1.58e-05	4	57	2	19542364
Pubmed	Dynamic changes in the expression of protein tyrosine phosphatases during preimplantation mouse development: semi-quantification by real-time PCR.	PTPN11 PTPRF	1.58e-05	4	57	2	14967925
Pubmed	The language phenotype of children and adolescents with Noonan syndrome.	PTPN11 BRAF	1.58e-05	4	57	2	20543023
Pubmed	PTPN11 Plays Oncogenic Roles and Is a Therapeutic Target for BRAF Wild-Type Melanomas.	PTPN11 BRAF	1.58e-05	4	57	2	30355677
Pubmed	Noonan Syndrome with Multiple Lentigines	PTPN11 BRAF	1.58e-05	4	57	2	20301557
Pubmed	The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1.	PTPRD PTPRF	1.58e-05	4	57	2	8524829
Pubmed	Mechanistic insights of NAC1 nuclear export and its role in ovarian cancer resistance to docetaxel.	CUL3 XPO1	1.58e-05	4	57	2	37019189
Pubmed	RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers.	PTPN11 BRAF	1.58e-05	4	57	2	30104724
Pubmed	CRM1-mediated recycling of snurportin 1 to the cytoplasm.	IPO7 XPO1	2.63e-05	5	57	2	10209022
Pubmed	Murine GBP-5, a new member of the murine guanylate-binding protein family, is coordinately regulated with other GBPs in vivo and in vitro.	GBP6 GBP1	2.63e-05	5	57	2	12396730
Pubmed	Multiple interactions between receptor protein-tyrosine phosphatase (RPTP) alpha and membrane-distal protein-tyrosine phosphatase domains of various RPTPs.	PTPRD PTPRF	2.63e-05	5	57	2	10777529
Pubmed	Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule.	PTPRD PTPRF	2.63e-05	5	57	2	22357843
Pubmed	Essential Role of mGBP7 for Survival of Toxoplasma gondii Infection.	IFNGR1 GBP1	2.63e-05	5	57	2	31964735
Pubmed	Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP.	PTPN11 LY9	2.63e-05	5	57	2	11389028
Pubmed	Maturation of ureter-bladder connection in mice is controlled by LAR family receptor protein tyrosine phosphatases.	PTPRD PTPRF	3.94e-05	6	57	2	19273906
Pubmed	RAS signaling dysregulation in human embryonal Rhabdomyosarcoma.	PTPN11 BRAF	3.94e-05	6	57	2	19681119
Pubmed	Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients.	PTPN11 LY9	3.94e-05	6	57	2	11477068
Pubmed	Some protein tyrosine phosphatases target in part to lipid rafts and interact with caveolin-1.	PTPN11 PTPRF	3.94e-05	6	57	2	12176037
Pubmed	Molecular characteristics in papillary thyroid cancers (PTCs) with no 131I uptake.	SLC5A5 BRAF	3.94e-05	6	57	2	17854396
Pubmed	Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.	PTPN11 LY9	3.94e-05	6	57	2	11689425
Pubmed	Comparison in localization between cystatin C and cathepsin K in osteoclasts and other cells in mouse tibia epiphysis by immunolight and immunoelectron microscopy.	CST5 CTSK	3.94e-05	6	57	2	11472890
Pubmed	Modulation of apoptotic response by LAR family phosphatases-cIAP1 signaling during urinary tract morphogenesis.	PTPRD PTPRF	5.51e-05	7	57	2	29073098
Pubmed	Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases.	PTPRD PTPRF	5.51e-05	7	57	2	12376545
Pubmed	Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum.	PTPN11 BRAF	5.51e-05	7	57	2	19206169
Pubmed	Investigation of gene dosage imbalances in patients with Noonan syndrome using multiplex ligation-dependent probe amplification analysis.	PTPN11 BRAF	5.51e-05	7	57	2	20302979
Pubmed	Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein.	PTPN11 PTPRF	5.51e-05	7	57	2	10660596
Pubmed	Cognitive profile of disorders associated with dysregulation of the RAS/MAPK signaling cascade.	PTPN11 BRAF	5.51e-05	7	57	2	19133693
Pubmed	Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.	IPO7 PTPRF PTPRK LY9	6.70e-05	132	57	4	26439863
Pubmed	Germline gain-of-function mutations in SOS1 cause Noonan syndrome.	PTPN11 BRAF	7.34e-05	8	57	2	17143285
Pubmed	MEKK4 signaling regulates filamin expression and neuronal migration.	FLNB MAP3K4	7.34e-05	8	57	2	17145501
Pubmed	Combinatorial expression of neurexins and LAR-type phosphotyrosine phosphatase receptors instructs assembly of a cerebellar circuit.	PTPRD PTPRF	7.34e-05	8	57	2	37591863
Pubmed	In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters.	GBP6 GBP1	7.34e-05	8	57	2	16689661
Pubmed	Protein Tyrosine Phosphatase δ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase.	PTPRD PTPRF	7.34e-05	8	57	2	28637841
Pubmed	Transportin 1 is a major nuclear import receptor of the nitric oxide synthase interacting protein.	IPO7 XPO1	7.34e-05	8	57	2	36690276
Pubmed	Type III interferon drives thymic B cell activation and regulatory T cell generation.	IFNGR1 MX1	7.34e-05	8	57	2	36802427
Pubmed	ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway.	FLNB MAP3K4	9.43e-05	9	57	2	19270716
Pubmed	Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes.	IPO7 XPO1	1.18e-04	10	57	2	10944119
Pubmed	PTPσ functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission.	PTPRD PTPRF	1.44e-04	11	57	2	25624497
Pubmed	A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain.	PTPRD PTPRF	1.44e-04	11	57	2	7832766
Pubmed	The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability.	CUL3 ZNF350	1.44e-04	11	57	2	27621083
Pubmed	Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense.	GBP6 GBP1	1.44e-04	11	57	2	18025219
Pubmed	Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.	PTPRD PTPRF PTPRK LY9	1.48e-04	162	57	4	25826454
Pubmed	Impact of lactobacilli on orally acquired listeriosis.	GBP6 GBP1 ABCD2 MX1	1.48e-04	162	57	4	23012479
Pubmed	Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.	PTPRD PTPRF	1.72e-04	12	57	2	9624153
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	FLNB PTPN11 PTPRD IPO7 PTPRF PTPRK DHPS XPO1	1.80e-04	974	57	8	28675297
Pubmed	Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.	CUL3 FLNB PTPN11 IPO7 PCID2	2.00e-04	327	57	5	15592455
Pubmed	Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor.	PTPN11 BRAF	2.03e-04	13	57	2	27799550
Pubmed	Allogeneic B cell immunomodulatory therapy in amyotrophic lateral sclerosis.	MX1 GABRA2	2.37e-04	14	57	2	38967302
Pubmed	Noradrenergic circuit control of non-REM sleep substates.	MX1 GABRA2	2.37e-04	14	57	2	34648731
Pubmed	Phosphoproteomic of the acetylcholine pathway enables discovery of the PKC-β-PIX-Rac1-PAK cascade as a stimulatory signal for aversive learning.	MX1 GABRA2	2.37e-04	14	57	2	35665767
Pubmed	Early loss of cerebellar Purkinje cells in human and a transgenic mouse model of Alzheimer's disease.	MX1 GABRA2	2.37e-04	14	57	2	33688799
Pubmed	Axotomy-induced target disconnection promotes an additional death mechanism involved in motoneuron degeneration in amyotrophic lateral sclerosis transgenic mice.	MX1 GABRA2	2.37e-04	14	57	2	24424947
Pubmed	The activity of the aryl hydrocarbon receptor in T cells tunes the gut microenvironment to sustain autoimmunity and neuroinflammation.	MX1 GABRA2	2.37e-04	14	57	2	36787309
Pubmed	Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity.	IFNGR1 BRAF	2.37e-04	14	57	2	25968334
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	PTPN11 TENM3 PPIP5K2 PPAT PUM1 MAP3K4	2.43e-04	536	57	6	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	PTPN11 TENM3 PPIP5K2 PPAT PUM1 MAP3K4	2.48e-04	538	57	6	10512203
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	FLNB PTPN11 MAN2B2 IPO7 XPO1	2.53e-04	344	57	5	30333137
Pubmed	A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.	PTPRK HLTF ARMCX2	2.59e-04	75	57	3	15383276
Pubmed	Inducing and measuring apoptotic cell death in mouse pancreatic β-cells and in isolated islets.	MX1 GABRA2	2.73e-04	15	57	2	35719268
Pubmed	AdipoRon accelerates bone repair of calvarial defect in diet-induced obesity mice.	MX1 GABRA2	2.73e-04	15	57	2	36873496
Pubmed	Behavioral and cortical arousal from sleep, muscimol-induced coma, and anesthesia by direct optogenetic stimulation of cortical neurons.	MX1 GABRA2	2.73e-04	15	57	2	38812551
Pubmed	Noonan Syndrome	PTPN11 BRAF	2.73e-04	15	57	2	20301303
Pubmed	Activation of neuronal Ras-related C3 botulinum toxin substrate 1 (Rac1) improves post-stroke recovery and axonal plasticity in mice.	MX1 GABRA2	2.73e-04	15	57	2	32964455
Pubmed	δ-Catenin controls astrocyte morphogenesis via layer-specific astrocyte-neuron cadherin interactions.	MX1 GABRA2	2.73e-04	15	57	2	37707499
Pubmed	Intestinal transit-amplifying cells require METTL3 for growth factor signaling and cell survival.	MX1 GABRA2	2.73e-04	15	57	2	37883185
Pubmed	ERG K+ channels mediate a major component of action potential repolarization in lymphatic muscle.	MX1 GABRA2	2.73e-04	15	57	2	37689781
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PTPN11 PTPRD IPO7 PTPRF PTPRK DHPS XPO1 PUM1	2.97e-04	1049	57	8	27880917
Pubmed	Tonic activity in lateral habenula neurons acts as a neutral valence brake on reward-seeking behavior.	MX1 GABRA2	3.12e-04	16	57	2	36049479
Pubmed	Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis.	SLC5A5 BRAF	3.12e-04	16	57	2	38750011
Pubmed	Asprosin-neutralizing antibodies as a treatment for metabolic syndrome.	MX1 GABRA2	3.12e-04	16	57	2	33904407
Pubmed	Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage.	IPO7 HLTF	3.53e-04	17	57	2	21825151
Pubmed	Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis.	MX1 GABRA2	3.53e-04	17	57	2	30995469
Pubmed	The bone microenvironment invigorates metastatic seeds for further dissemination.	MX1 GABRA2	3.53e-04	17	57	2	33878291
Cytoband	6q26	PDE10A MAP3K4	2.29e-04	18	57	2	6q26
Cytoband	1p22.2	GBP6 GBP1	5.61e-04	28	57	2	1p22.2
Cytoband	19q13.41	ZNF350 ZNF615	4.28e-03	78	57	2	19q13.41
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRD PTPRF PTPRK	1.51e-05	21	42	3	813
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	BRAF MAP3K4	1.41e-03	24	42	2	654
Coexpression	GSE16385_IFNG_TNF_VS_UNSTIM_MACROPHAGE_ROSIGLITAZONE_TREATED_UP	RASIP1 STIM2 SLC35A4 GBP1 ZNF350 XPO1	3.58e-06	190	57	6	M8021
ToppCell	metastatic_Brain-Fibroblasts-Myofibroblasts\|metastatic_Brain / Location, Cell class and cell subclass	FMOD PTPRD TENM3 ARMCX2 CTSK	3.52e-06	181	57	5	bd0b5f74f9c81ec0f1592710774a4fdf33d9d5a9
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	RASIP1 FLNB STIM2 GBP6 MX1	5.73e-06	200	57	5	3585484c7e24e941708bee471ca607d8ccee74e6
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_and_Lobular_Carcinoma-6\|TCGA-Breast / Sample_Type by Project: Shred V9	PTPRD TENM3 PPIP5K2 CTSK	3.98e-05	149	57	4	3904f8ce9078de238600ceceee0116af52256a1c
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	RASIP1 FLNB ARSJ PDE10A	6.06e-05	166	57	4	f7926ee266dcbf10df375cd921f1db5a2fa604f8
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC5A5 FMOD TTC28 ATP13A5	7.11e-05	173	57	4	2acd0693a2dfe04e3c1b2125ea63efe92d13150b
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC5A5 FMOD TTC28 ATP13A5	7.11e-05	173	57	4	2415b6ff49f334da570577d4e93484d024a3dbd5
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MAN2B2 TENM3 LRRC3B CTSK	7.77e-05	177	57	4	30f82b04e48940bfcaf2c22677efe6d57ae3f1a7
ToppCell	Pericytes-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	FLNB FMOD LZTS1 PDE10A	8.47e-05	181	57	4	35c470988a93381eefa300831aabb813fa1b90bd
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RASIP1 FLNB LZTS1 ARMCX2	9.03e-05	184	57	4	087666ba949b129c53d7ace40f9e543e3875a7de
ToppCell	pdx-Tumor_cells-T0\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	TENM3 PTPRK MYLIP PUM1	9.22e-05	185	57	4	1d874608aa2062024323512f68889219471b2f00
ToppCell	Control-Endothelial-Endothelial-Artery\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FLNB ARSJ LRRC3B PDE10A	9.41e-05	186	57	4	2d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCell	droplet-Lung-nan-21m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASIP1 FLNB LZTS1 ARMCX2	9.41e-05	186	57	4	5d0cd07b6b51e8ce9e1da949f757dc4575ec5752
ToppCell	critical-Myeloid-Monocyte-derived_Macrophage\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ARSJ HDX GBP1 MX1	9.61e-05	187	57	4	72e4aec49ea0c5fe6cee2a1a46369dbc90cd3fad
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RASIP1 FLNB STIM2 MX1	9.61e-05	187	57	4	dffa8447c2f3fdacf39a7258c6b4e81a25245041
ToppCell	COVID-19-Endothelial_cells-Endothelial_cells_(general)\|COVID-19 / group, cell type (main and fine annotations)	RASIP1 TTC28 PTPRK PDE10A	1.02e-04	190	57	4	812e11314c76c0179fbe5a9bea29b41ce5cbc93d
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-AEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	RASIP1 FLNB TTC28 PDE10A	1.04e-04	191	57	4	50601ef0a5a8f2c2120922989e08e85bf2d9b4ab
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PTPRF TENM3 KATNAL1 PDE10A	1.04e-04	191	57	4	b51e0f5d1b93f526160c904e9091313a5364f3a7
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Artery\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RASIP1 FLNB LRRC3B PDE10A	1.04e-04	191	57	4	4b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FMOD TENM3 PTPRK LRRC3B	1.09e-04	193	57	4	7cd9671e0ac64f7f3607f564485c63abbb7e7a63
ToppCell	TCGA-Blood_and_Bone_Marrow-Primary_Tumor-Diffuse_large_B-cell_lymphoma-DLBCL-1\|TCGA-Blood_and_Bone_Marrow / Sample_Type by Project: Shred V9	ARSJ FMOD TENM3 PTPRK	1.11e-04	194	57	4	eaeeb84576270cc3fc59002ba33bff9639bb0b02
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	PTPRD BRAF TTC28 PTPRK	1.15e-04	196	57	4	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	COVID-19-lung-Capillary_1\|lung / Disease (COVID-19 only), tissue and cell type	RASIP1 TTC28 PTPRK PDE10A	1.17e-04	197	57	4	7e86ff9dafcbaaa7464d61484dd48bfeb7eae6e4
ToppCell	(2)_Fibroblasts-(22)_Fibro-3\|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis	FMOD TENM3 LZTS1 CTSK	1.17e-04	197	57	4	d9021bab82403e566ec10f78acb227c0f80b88fe
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMOD PTPRD TENM3 CTSK	1.17e-04	197	57	4	cfd4cc5fb8d7a60dd5c0d2a1a7bad7ba38c19d40
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FMOD TENM3 PTPRK LRRC3B	1.20e-04	198	57	4	12cd9f0bbad8dce5199ebfed1c4a8080710ca055
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	PTPRD BRAF TTC28 PTPRK	1.20e-04	198	57	4	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	Control-Control-Lymphocyte-T/NK-CD4+_T_activated\|Control / Disease, condition lineage and cell class	APPL2 GBP1 ZNF615 MX1	1.20e-04	198	57	4	ee71543559836fd59adc0da877b2ca538cba60cb
ToppCell	distal-Endothelial-Artery-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TTC28 LRRC3B MYLIP PDE10A	1.22e-04	199	57	4	8acf381087268fcf13f025e3b67e028bf1f9b77e
ToppCell	control-Epithelial-Secretory\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	IFNGR1 FLNB PTPRK NBEAL1	1.22e-04	199	57	4	3d01f90ffd271ca00129192787e4921bdca7e01e
ToppCell	control-Epithelial-Secretory\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	IFNGR1 FLNB PTPRK NBEAL1	1.22e-04	199	57	4	262e5b8a52c8ddb0b47048c786e8bdb7158e1b9a
ToppCell	Biopsy_Other_PF-Mesenchymal-Myofibroblasts\|Biopsy_Other_PF / Sample group, Lineage and Cell type	FMOD PTPRD TENM3 CTSK	1.24e-04	200	57	4	e504570fd7eec1524c401b1cfa9d10822d80d994
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	RASIP1 STIM2 GBP6 MX1	1.24e-04	200	57	4	89821a264e872ed53e08e9d3609d5cc5c314503e
Disease	Noonan syndrome with multiple lentigines	PTPN11 BRAF	1.02e-05	3	55	2	cv:C0175704
Disease	NOONAN SYNDROME 1	PTPN11 BRAF	1.02e-05	3	55	2	163950
Disease	Noonan syndrome 1	PTPN11 BRAF	1.02e-05	3	55	2	cv:C4551602
Disease	systemic scleroderma, rheumatoid arthritis, myositis, systemic lupus erythematosus	FLNB PTPN11 PHTF1	4.94e-05	38	55	3	EFO_0000685, EFO_0000717, EFO_0000783, MONDO_0007915
Disease	Leopard Syndrome 1	PTPN11 BRAF	5.09e-05	6	55	2	C4551484
Disease	Kidney Neoplasm	SLC5A5 BRAF HLTF	5.77e-05	40	55	3	C0022665
Disease	Malignant neoplasm of kidney	SLC5A5 BRAF HLTF	8.23e-05	45	55	3	C0740457
Disease	melanoma	SLC5A5 CUL3 IQCH BRAF PTPRK	9.95e-05	248	55	5	C0025202
Disease	Noonan syndrome	PTPN11 BRAF	1.22e-04	9	55	2	cv:C0028326
Disease	cerebrospinal fluid biomarker measurement, t-tau measurement	BRAF TTC28	1.22e-04	9	55	2	EFO_0004760, EFO_0006794
Disease	Prostatic Neoplasms	SLC5A5 CUL3 APPL2 BRAF PTPRK LZTS1 XPO1	1.42e-04	616	55	7	C0033578
Disease	Malignant neoplasm of prostate	SLC5A5 CUL3 APPL2 BRAF PTPRK LZTS1 XPO1	1.42e-04	616	55	7	C0376358
Disease	Turner Syndrome, Male	PTPN11 BRAF	1.86e-04	11	55	2	C0041409
Disease	Female Pseudo-Turner Syndrome	PTPN11 BRAF	1.86e-04	11	55	2	C1527404
Disease	Noonan Syndrome 1	PTPN11 BRAF	1.86e-04	11	55	2	C4551602
Disease	periodontitis (is_marker_for)	IFNGR1 FMOD	2.22e-04	12	55	2	DOID:824 (is_marker_for)
Disease	RASopathy	PTPN11 BRAF	3.53e-04	15	55	2	cv:C5555857
Disease	Disproportionate short stature	FLNB PTPN11 CTSK	4.07e-04	77	55	3	C0878659
Disease	short-term memory	PTPRD PTPRK MCM9	5.07e-04	83	55	3	EFO_0004335
Disease	Noonan-Like Syndrome With Loose Anagen Hair	PTPN11 BRAF	5.72e-04	19	55	2	C3501846
Disease	Costello syndrome (disorder)	PTPN11 BRAF	5.72e-04	19	55	2	C0587248
Disease	Noonan syndrome-like disorder with loose anagen hair	PTPN11 BRAF	5.72e-04	19	55	2	C1843181
Disease	Cardio-facio-cutaneous syndrome	PTPN11 BRAF	5.72e-04	19	55	2	C1275081
Disease	LEOPARD Syndrome	PTPN11 BRAF	7.69e-04	22	55	2	C0175704
Disease	Noonan Syndrome	PTPN11 BRAF	9.17e-04	24	55	2	C0028326
Disease	Cerebral Astrocytoma	PTPN11 BRAF	9.96e-04	25	55	2	C0750935
Disease	Intracranial Astrocytoma	PTPN11 BRAF	9.96e-04	25	55	2	C0750936
Disease	Pilocytic Astrocytoma	PTPN11 BRAF	9.96e-04	25	55	2	C0334583
Disease	Astrocytoma	PTPN11 BRAF	9.96e-04	25	55	2	C0004114
Disease	Juvenile Pilocytic Astrocytoma	PTPN11 BRAF	9.96e-04	25	55	2	C0280783
Disease	Diffuse Astrocytoma	PTPN11 BRAF	9.96e-04	25	55	2	C0280785
Disease	Grade I Astrocytoma	PTPN11 BRAF	9.96e-04	25	55	2	C1704230
Disease	Subependymal Giant Cell Astrocytoma	PTPN11 BRAF	9.96e-04	25	55	2	C0205768
Disease	Mixed oligoastrocytoma	PTPN11 BRAF	9.96e-04	25	55	2	C0547065
Disease	Childhood Cerebral Astrocytoma	PTPN11 BRAF	9.96e-04	25	55	2	C0338070
Disease	Gemistocytic astrocytoma	PTPN11 BRAF	1.08e-03	26	55	2	C0334581
Disease	Protoplasmic astrocytoma	PTPN11 BRAF	1.08e-03	26	55	2	C0334580
Disease	Fibrillary Astrocytoma	PTPN11 BRAF	1.08e-03	26	55	2	C0334582
Disease	Cholangiocarcinoma	SLC5A5 BRAF	1.08e-03	26	55	2	C0206698
Disease	Anaplastic astrocytoma	PTPN11 BRAF	1.16e-03	27	55	2	C0334579
Disease	azoospermia (implicated_via_orthology)	PTPRD PTPRF	1.16e-03	27	55	2	DOID:14227 (implicated_via_orthology)
Disease	lymphocyte measurement	TTC28 LZTS1 LY9	1.37e-03	117	55	3	EFO_0803546
Disease	aspartate aminotransferase measurement	RASIP1 FLNB PTPN11 PTPRD TTC28 LZTS1 CTSK	1.40e-03	904	55	7	EFO_0004736
Disease	blood viscosity	PTPRD PTPRF	1.53e-03	31	55	2	EFO_0004301
Disease	Colorectal Neoplasms	PTPRD BRAF LRRC3B ABCD2	1.78e-03	277	55	4	C0009404

Protein segments in the cluster

Peptide	Gene	Start	Entry
YMTNAFQYVQKNRGI	CTSK	181	P43235
YSNINNRDQIIFMVG	BRAF	656	P15056
MFLTQVAYQVGNYEL	CFAP54	1021	Q96N23
QLQLFGNYQYLMQDV	ATP13A5	926	Q4VNC0
TVYQGMYNAITRQVE	AKR7A3	166	O95154
QTYYKVINMDGRLAN	ABCD2	191	Q9UBJ2
SENYENQGRLQVYMN	ARMCX2	456	Q7L311
DYLIQINTMAGRTYN	NBEAL1	2016	Q6ZS30
LQGYQDAQDFVVYVM	RASIP1	386	Q5U651
GIYDIYSQQQMIEQL	IQCH	626	Q86VS3
RMKYVYFQNNQITSI	FMOD	106	Q06828
QQRILQRYYENGMTN	HDX	11	Q7Z353
LQQSYVAMYQRNQRL	LZTS1	546	Q9Y250
IYSTQMYTQRVQQIL	ARSJ	236	Q5FYB0
MIQNNAYAVAVANYA	GABRA2	361	P47869
MKHVGNQQYNVTYVV	FLNB	2561	O75369
NQVAVNMYKQLGYSV	NAA20	116	P61599
YMAPRVLQQTLNYIN	IPO7	316	O95373
MQGVVYELNSYIEQR	PDE10A	71	Q9Y233
AEYQVLQIVSAMENY	MYLIP	171	Q8WY64
IGTINQQAMDQLYYV	GBP1	131	P32455
AVQRAADYYSQQMAQ	GBP6	326	Q6ZN66
MVISYVVYYVRQNQE	LRRC3B	216	Q96PB8
QTEAQYRFIYMAVQH	PTPN11	506	Q06124
LQAAYQLMVDVFGNY	PUM1	886	Q14671
MAHITINQYLQQVYE	PCID2	1	Q5JVF3
YGIMVNNDAVVRNVY	IFT52	106	Q9Y366
MRNGADYAVYINTAQ	DHPS	296	P49366
MDRVYVQQNNVENVY	CUL3	126	Q13618
VMAAYQQIVGGVNYY	CST5	71	P28325
YTNQLLQAMQRVYGA	APPL2	36	Q8NEU8
VVGENTMYAQVFNLQ	LY9	596	Q9HBG7
QQVIYSDNNGYQMQR	MAN2B2	726	Q9Y2E5
RYYTGVVNNNEMVAL	HLTF	71	Q14527
VYNVYVRMNGSEIQY	IFNGR1	171	P15260
QRNYMVQTEDQYVFI	PTPRF	1586	P10586
TRPQEGYLMVQQFQY	PTPRK	1321	Q15262
QRNYMVQTEDQYIFI	PTPRD	1591	P23468
VTLQQYYREAMIQGY	MAP3K4	1026	Q9Y6R4
VGNQVLLRYYQMQRQ	MCM9	541	Q9NXL9
MVYYQGVMQQIQRHC	KATNAL1	26	Q9BW62
YRNVKMNYNALITVG	PRDM7	51	Q9NQW5
MQNYLRQQILFYQRV	SNX33	546	Q8WV41
VMLENYSNLVAVGYQ	ZNF615	36	Q8N8J6
QNMNTKYYGLQILEN	XPO1	71	O14980
YGTSQVQYDVVVQML	RIBC1	66	Q8N443
RVNAYQQGVGYQMLG	PHTF1	466	Q9UMS5
LSMYGVNQAQVQRYV	SLC5A5	256	Q92911
VEVQYYNIKRQNAEM	STIM2	361	Q9P246
DQMVYTVRYRCGQQL	PPAT	296	Q06203
YGANNNLVIYLQRYM	SLC35A4	96	Q96G79
TMVQDQLRNSYQIGY	TENM3	1686	Q9P273
QGYQEGNINQKMISY	ZNF780A	131	O75290
VMLENYSNLVAVGYQ	ZNF350	36	Q9GZX5
QNYSQAVMYLQEGLR	TTC28	1091	Q96AY4
YLNVVNELNYMTQIV	PPIP5K2	856	O43314
QMEQIVYCQDQVYRG	MX1	526	P20591