Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	olfactory receptor activity	OR7D4 OR7C2 OR2T7 OR2T1 OR2T2 OR2B3 OR2Z1 OR2T10 OR1L3 OR1L1 OR4C5 OR2AJ1 OR1L4	3.33e-08	431	85	13	GO:0004984
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF502 ZNF750 ZBTB49 ZNF486 ZNF497 SALL3 ZNF41 PATZ1 ZNF423 ZNF335 SKOR2 BACH1 ZNF483 ZNF267 ZNF521 ZNF236 ZNF501 ZNF774 PASD1	8.96e-07	1244	85	19	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF502 ZNF750 ZBTB49 ZNF486 ZNF497 SALL3 ZNF41 PATZ1 ZNF423 ZNF335 SKOR2 BACH1 ZNF483 ZNF267 ZNF521 ZNF236 ZNF501 ZNF774 PASD1	1.24e-06	1271	85	19	GO:0000987
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF502 ZNF750 ZBTB49 ZNF486 ZNF497 SALL3 ZNF41 PATZ1 ZNF423 ZNF335 SKOR2 BACH1 ZNF483 ZNF267 ZNF521 ZNF236 ZNF501 ZNF774 PASD1	9.28e-06	1459	85	19	GO:0000977
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR7D4 OR7C2 OR2T7 OR2T1 OR2T2 OR2B3 TSHR OR2Z1 OR2T10 OR1L3 OR1L1 OR4C5 OR2AJ1 OR1L4	2.04e-05	884	85	14	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR7D4 OR7C2 PIGR UNC5CL OR2T7 OR2T1 OR2T2 OR2B3 TSHR OR2Z1 OR2T10 OR1L3 OR1L1 OR4C5 OR2AJ1 OR1L4	1.65e-04	1353	85	16	GO:0004888
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF502 ZNF750 ZBTB49 ZNF486 SALL3 ZNF41 PATZ1 ZNF423 SKOR2 BACH1 ZNF483 ZNF267 ZNF521 ZNF236 ZNF774 PASD1	2.69e-04	1412	85	16	GO:0000981
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR7D4 OR7C2 PIGR OR2T7 OR2T1 OR2T2 OR2B3 OR2Z1 OR2T10 OR1L3 OR1L1 OR4C5 OR2AJ1 OR1L4	1.08e-08	485	85	14	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR7D4 OR7C2 OR2T7 OR2T1 OR2T2 OR2B3 OR2Z1 OR2T10 OR1L3 OR1L1 OR4C5 OR2AJ1 OR1L4	2.35e-08	432	85	13	GO:0050911
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR7D4 OR7C2 PIGR OR2T7 OR2T1 OR2T2 OR2B3 OR2Z1 OR2T10 OR1L3 OR1L1 OR4C5 OR2AJ1 OR1L4	2.86e-08	524	85	14	GO:0009593
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR7D4 OR7C2 PIGR OR2T7 OR2T1 OR2T2 OR2B3 OR2Z1 OR2T10 OR1L3 OR1L1 OR4C5 OR2AJ1 OR1L4	4.87e-08	547	85	14	GO:0007606
GeneOntologyBiologicalProcess	sensory perception of smell	OR7D4 OR7C2 OR2T7 OR2T1 OR2T2 OR2B3 OR2Z1 OR2T10 OR1L3 OR1L1 OR4C5 OR2AJ1 OR1L4	5.55e-08	465	85	13	GO:0007608
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR7D4 OR7C2 PIGR OR2T7 OR2T1 OR2T2 OR2B3 OR2Z1 OR2T10 OR1L3 OR1L1 OR4C5 OR2AJ1 OR1L4	1.05e-07	582	85	14	GO:0050906
GeneOntologyBiologicalProcess	detection of stimulus	OR7D4 OR7C2 PIGR OR2T7 OR2T1 OR2T2 OR2B3 OR2Z1 OR2T10 OR1L3 OR1L1 OR4C5 OR2AJ1 OR1L4	1.39e-06	722	85	14	GO:0051606
GeneOntologyBiologicalProcess	sensory perception	OR7D4 OR7C2 PIGR OR2T7 OR2T1 OR2T2 OR2B3 OR2Z1 OR2T10 OR1L3 OR1L1 OR4C5 OR2AJ1 OR1L4	1.16e-04	1072	85	14	GO:0007600
Domain	Znf_C2H2-like	ZNF502 ZNF750 ZBTB49 ZNF346 ZNF486 ZNF497 SALL3 ZNF41 PATZ1 ZNF423 ZNF335 ZNF483 ZNF267 ZNF521 ZNF407 ZNF236 ZNF501 ZNF774	1.77e-08	796	86	18	IPR015880
Domain	Znf_C2H2	ZNF502 ZNF750 ZBTB49 ZNF346 ZNF486 ZNF497 SALL3 ZNF41 PATZ1 ZNF423 ZNF335 ZNF483 ZNF267 ZNF521 ZNF407 ZNF236 ZNF501 ZNF774	2.11e-08	805	86	18	IPR007087
Domain	ZnF_C2H2	ZNF502 ZNF750 ZBTB49 ZNF346 ZNF486 ZNF497 SALL3 ZNF41 PATZ1 ZNF423 ZNF335 ZNF483 ZNF267 ZNF521 ZNF407 ZNF236 ZNF501 ZNF774	2.23e-08	808	86	18	SM00355
Domain	-	ZNF502 ZBTB49 ZNF486 ZNF497 SALL3 ZNF41 PATZ1 ZNF423 ZNF335 ZNF483 ZNF267 ZNF521 ZNF407 ZNF236 ZNF501 ZNF774	7.06e-08	679	86	16	3.30.160.60
Domain	zf-C2H2	ZNF502 ZBTB49 ZNF486 ZNF497 SALL3 ZNF41 PATZ1 ZNF423 ZNF335 ZNF483 ZNF267 ZNF521 ZNF407 ZNF236 ZNF501 ZNF774	9.33e-08	693	86	16	PF00096
Domain	Interferon_reg_fac2-bd1_2_Znf	IRF2BP2 IRF2BP1 IRF2BPL	9.43e-08	3	86	3	IPR022750
Domain	IRF-2BP1_2	IRF2BP2 IRF2BP1 IRF2BPL	9.43e-08	3	86	3	PF11261
Domain	Znf_C2H2/integrase_DNA-bd	ZNF502 ZBTB49 ZNF486 ZNF497 SALL3 ZNF41 PATZ1 ZNF423 ZNF335 ZNF483 ZNF267 ZNF521 ZNF407 ZNF236 ZNF501 ZNF774	9.52e-08	694	86	16	IPR013087
Domain	zf-C2H2_6	ZNF502 ZBTB49 ZNF486 ZNF497 PATZ1 ZNF423 ZNF483 ZNF267 ZNF521 ZNF236 ZNF501	2.03e-07	314	86	11	PF13912
Domain	Olfact_rcpt	OR7D4 OR7C2 OR2T1 OR2T2 OR2B3 OR2Z1 OR2T10 OR1L3 OR1L1 OR4C5 OR2AJ1 OR1L4	2.40e-07	393	86	12	IPR000725
Domain	ZINC_FINGER_C2H2_2	ZNF502 ZBTB49 ZNF486 ZNF497 SALL3 ZNF41 PATZ1 ZNF423 ZNF335 ZNF483 ZNF267 ZNF521 ZNF407 ZNF236 ZNF501 ZNF774	4.23e-07	775	86	16	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF502 ZBTB49 ZNF486 ZNF497 SALL3 ZNF41 PATZ1 ZNF423 ZNF335 ZNF483 ZNF267 ZNF521 ZNF407 ZNF236 ZNF501 ZNF774	4.37e-07	777	86	16	PS00028
Domain	7tm_1	OR7D4 OR7C2 OR2T1 OR2T2 OR2B3 TSHR OR2Z1 OR2T10 OR1L3 OR1L1 OR4C5 OR2AJ1 OR1L4	1.27e-05	677	86	13	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR7D4 OR7C2 OR2T1 OR2T2 OR2B3 TSHR OR2Z1 OR2T10 OR1L3 OR1L1 OR4C5 OR2AJ1 OR1L4	1.43e-05	685	86	13	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR7D4 OR7C2 OR2T1 OR2T2 OR2B3 TSHR OR2Z1 OR2T10 OR1L3 OR1L1 OR4C5 OR2AJ1 OR1L4	1.57e-05	691	86	13	PS50262
Domain	GPCR_Rhodpsn	OR7D4 OR7C2 OR2T1 OR2T2 OR2B3 TSHR OR2Z1 OR2T10 OR1L3 OR1L1 OR4C5 OR2AJ1 OR1L4	1.60e-05	692	86	13	IPR000276
Domain	GPCR_Rhodpsn_7TM	OR7D4 OR7C2 OR2T1 OR2T2 OR2B3 TSHR OR2Z1 OR2T10 OR1L3 OR1L1 OR1L4	2.47e-04	670	86	11	IPR017452
Domain	-	HSPA4L HSPA4	1.34e-03	12	86	2	2.60.34.10
Domain	HSP70_peptide-bd	HSPA4L HSPA4	1.34e-03	12	86	2	IPR029047
Domain	ZnF_C3H1	ZC3H14 RC3H2 RC3H1	1.40e-03	48	86	3	SM00356
Domain	-	HSPA4L HSPA4	1.58e-03	13	86	2	1.20.1270.10
Domain	Heat_shock_70_CS	HSPA4L HSPA4	1.58e-03	13	86	2	IPR018181
Domain	HSP70_C	HSPA4L HSPA4	1.58e-03	13	86	2	IPR029048
Domain	HSP70	HSPA4L HSPA4	2.41e-03	16	86	2	PF00012
Domain	Znf_CCCH	ZC3H14 RC3H2 RC3H1	2.42e-03	58	86	3	IPR000571
Domain	ZF_C3H1	ZC3H14 RC3H2 RC3H1	2.42e-03	58	86	3	PS50103
Domain	HSP70_2	HSPA4L HSPA4	2.72e-03	17	86	2	PS00329
Domain	HSP70_3	HSPA4L HSPA4	2.72e-03	17	86	2	PS01036
Domain	HSP70_1	HSPA4L HSPA4	2.72e-03	17	86	2	PS00297
Domain	Hsp_70_fam	HSPA4L HSPA4	3.06e-03	18	86	2	IPR013126
Domain	BTB	ZBTB49 BTBD8 PATZ1 BACH1	3.15e-03	131	86	4	PF00651
Domain	Znf_RING/FYVE/PHD	PHF1 RC3H2 ZNF423 RC3H1 ZNF521 IRF2BPL TRIM38	5.24e-03	459	86	7	IPR013083
Domain	BTB	ZBTB49 BTBD8 PATZ1 BACH1	6.39e-03	160	86	4	PS50097
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR7D4 OR7C2 OR2T7 OR2T1 OR2T2 OR2B3 OR2Z1 OR2T10 OR1L3 OR1L1 OR4C5 OR2AJ1 OR1L4	3.67e-08	417	64	13	M4072
Pathway	REACTOME_SENSORY_PERCEPTION	OR7D4 OR7C2 OR2T7 OR2T1 OR2T2 OR2B3 OR2Z1 OR2T10 OR1L3 OR1L1 OR4C5 OR2AJ1 OR1L4	4.45e-06	636	64	13	M41834
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR7D4 OR7C2 OR2T1 OR2T2 OR2B3 OR2Z1 OR2T10 OR1L3 OR1L1 OR1L4	9.14e-06	389	64	10	M14091
Pubmed	The human olfactory receptor gene family.	OR7D4 OR7C2 OR2T7 OR2T1 OR2T2 OR2B3 OR2Z1 OR2T10 OR1L3 OR1L1 OR4C5 OR2AJ1 OR1L4	9.70e-10	541	87	13	14983052
Pubmed	A novel transcription complex that selectively modulates apoptosis of breast cancer cells through regulation of FASTKD2.	IRF2BP2 IRF2BP1 IRF2BPL	6.04e-08	4	87	3	21444724
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR7D4 OR7C2 OR2T7 OR2T1 OR2T2 OR2B3 OR2Z1 OR1L4	8.29e-08	219	87	8	12213199
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	TRMU IRF2BP2 RC3H2 DST IRF2BPL POMT1 ST14 DNMT1	1.92e-06	332	87	8	37433992
Pubmed	Bpag1 localization to actin filaments and to the nucleus is regulated by its N-terminus.	DST PXN	6.19e-06	2	87	2	14576348
Pubmed	Cloning of human cDNAs for Apg-1 and Apg-2, members of the Hsp110 family, and chromosomal assignment of their genes.	HSPA4L HSPA4	6.19e-06	2	87	2	10524232
Pubmed	Paxillin regulates pulmonary arterial smooth muscle cell function in pulmonary hypertension.	PXN FHL1	6.19e-06	2	87	2	22959909
Pubmed	Structure of human Roquin-2 and its complex with constitutive-decay element RNA.	RC3H2 RC3H1	6.19e-06	2	87	2	26249698
Pubmed	Secretory IgA is Concentrated in the Outer Layer of Colonic Mucus along with Gut Bacteria.	PIGR MUC2	6.19e-06	2	87	2	25437806
Pubmed	Evi3, a common retroviral integration site in murine B-cell lymphoma, encodes an EBFAZ-related Krüppel-like zinc finger protein.	ZNF423 ZNF521	6.19e-06	2	87	2	12393497
Pubmed	Direct transcriptional repression of Zfp423 by Zfp521 mediates a bone morphogenic protein-dependent osteoblast versus adipocyte lineage commitment switch.	ZNF423 ZNF521	1.85e-05	3	87	2	24891617
Pubmed	ZNF423 and ZNF521: EBF1 Antagonists of Potential Relevance in B-Lymphoid Malignancies.	ZNF423 ZNF521	1.85e-05	3	87	2	26788497
Pubmed	Roquin targets mRNAs in a 3'-UTR-specific manner by different modes of regulation.	RC3H2 RC3H1	1.85e-05	3	87	2	30232334
Pubmed	Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation.	RC3H2 RC3H1	1.85e-05	3	87	2	23583642
Pubmed	Roquin Paralogs Differentially Regulate Functional NKT Cell Subsets.	RC3H2 RC3H1	1.85e-05	3	87	2	28188245
Pubmed	Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation.	RC3H2 RC3H1	1.85e-05	3	87	2	25026077
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR7D4 OR7C2 OR2T1 OR2Z1 OR4C5 OR2AJ1 OR1L4	2.40e-05	340	87	7	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR7D4 OR7C2 OR2T1 OR2Z1 OR4C5 OR2AJ1 OR1L4	2.40e-05	340	87	7	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR7D4 OR7C2 OR2T1 OR2Z1 OR4C5 OR2AJ1 OR1L4	2.54e-05	343	87	7	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR7D4 OR7C2 OR2T1 OR2Z1 OR4C5 OR2AJ1 OR1L4	2.68e-05	346	87	7	14611657
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	PHF1 ZNF750 ZNF346 SALL3 PATZ1 ZNF423 BACH1 PXN ZNF236 DNMT1	3.46e-05	808	87	10	20412781
Pubmed	Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis.	RC3H2 RC3H1	3.70e-05	4	87	2	25697406
Pubmed	A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain.	PATZ1 BACH1	3.70e-05	4	87	2	10669750
Pubmed	A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation.	RC3H2 RC3H1	3.70e-05	4	87	2	31636267
Pubmed	Control of developmentally primed erythroid genes by combinatorial co-repressor actions.	IRF2BP2 IRF2BP1 IRF2BPL	5.85e-05	30	87	3	26593974
Pubmed	Identification of novel co-repressor molecules for Interferon Regulatory Factor-2.	IRF2BP2 IRF2BP1	6.16e-05	5	87	2	12799427
Pubmed	Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40.	RC3H2 RC3H1	6.16e-05	5	87	2	27010430
Pubmed	Role for PADI6 and the cytoplasmic lattices in ribosomal storage in oocytes and translational control in the early mouse embryo.	POLR2A DNMT1	6.16e-05	5	87	2	18599511
Pubmed	Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells.	ZNF423 ZNF521	6.16e-05	5	87	2	14630787
Pubmed	Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry.	IRF2BP2 HSPA4L POLA1 POLR2A IRF2BPL SLFN14 DNMT1	7.93e-05	411	87	7	36652389
Pubmed	Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR.	PATZ1 DNMT1	9.22e-05	6	87	2	16491076
Pubmed	Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation.	RC3H2 RC3H1	9.22e-05	6	87	2	34471108
Pubmed	DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.	PHF1 POLR2A WDR70 DNMT1	1.15e-04	99	87	4	34161765
Pubmed	Promoter methylation analysis of WNT/β-catenin pathway regulators and its association with expression of DNMT1 enzyme in colorectal cancer.	SFRP2 DNMT1	1.29e-04	7	87	2	25107489
Pubmed	A novel HSF1-mediated death pathway that is suppressed by heat shock proteins.	HSPA4L HSPA4	1.29e-04	7	87	2	17024176
Pubmed	Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses.	RC3H2 RC3H1	1.29e-04	7	87	2	34811541
Pubmed	Human cytomegalovirus induces and exploits Roquin to counteract the IRF1-mediated antiviral state.	RC3H1 IRF2BPL	1.29e-04	7	87	2	31451648
Pubmed	The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1.	HSPA4 DNMT1	1.29e-04	7	87	2	21745816
Pubmed	Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation.	RC3H2 RC3H1	1.72e-04	8	87	2	25282160
Pubmed	Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells.	RC3H2 RC3H1	1.72e-04	8	87	2	29246441
Pubmed	Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.	RC3H2 RC3H1	1.72e-04	8	87	2	29352114
Pubmed	Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.	INHBA SKOR2 ZNF483	2.12e-04	46	87	3	21102462
Pubmed	Mapping of nine porcine interferon regulatory factor genes.	IRF2BP2 IRF2BP1	2.20e-04	9	87	2	17121613
Pubmed	Activin and Bmp4 Signaling Converge on Wnt Activation during Odontogenesis.	SFRP2 INHBA	2.20e-04	9	87	2	28605600
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	PHF1 DST PXN ZNF407 FHL1 TRIM38 ZMYM4	2.55e-04	497	87	7	23414517
Pubmed	Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS.	HSPA4L HSPA4	2.75e-04	10	87	2	19171884
Pubmed	Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions.	ZNF521 IRF2BPL	3.35e-04	11	87	2	22379998
Pubmed	Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation.	RC3H2 RC3H1	3.35e-04	11	87	2	23583643
Pubmed	Identification of new high affinity targets for Roquin based on structural conservation.	RC3H2 RC3H1	3.35e-04	11	87	2	30295819
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	PHF1 POLA1 ZNF335 SKOR2 ZNF483 USP4 IRF2BPL CATSPERG	3.37e-04	689	87	8	36543142
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	ZNF502 PHF1 IRF2BP1 ZNF41 POLR2A BACH1 ZNF407 ZNF236 DNMT1	3.51e-04	877	87	9	20211142
Pubmed	Respiratory distress and early neonatal lethality in Hspa4l/Hspa4 double-mutant mice.	HSPA4L HSPA4	4.02e-04	12	87	2	23980576
Pubmed	Heat-shock protein HSPA4 is required for progression of spermatogenesis.	HSPA4L HSPA4	4.02e-04	12	87	2	21487003
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	RC3H2 DST HSPA4L PATZ1 WDR70 HSPA4 ZMYM4	4.52e-04	547	87	7	37267103
Pubmed	ZNF198 stabilizes the LSD1-CoREST-HDAC1 complex on chromatin through its MYM-type zinc fingers.	HSPA4 ZMYM4	4.74e-04	13	87	2	18806873
Pubmed	Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.	DST INHBA SKOR2 ZNF483	5.46e-04	149	87	4	25231870
Pubmed	Zfp423/ZNF423 regulates cell cycle progression, the mode of cell division and the DNA-damage response in Purkinje neuron progenitors.	ZNF423 SKOR2	5.52e-04	14	87	2	28893945
Pubmed	System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.	POLR2A DNMT1	6.36e-04	15	87	2	21406692
Pubmed	Zfp423/OAZ participates in a developmental switch during olfactory neurogenesis.	ZNF423 ZNF521	7.26e-04	16	87	2	17521568
Pubmed	Structural and functional consequences of NEDD8 phosphorylation.	HSPA4L USP4 HSPA4	7.33e-04	70	87	3	34642328
Pubmed	New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.	RC3H2 RC3H1	8.21e-04	17	87	2	26489670
Pubmed	Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping.	ZNF407 ZNF236	8.21e-04	17	87	2	19690890
Pubmed	Odorant and vomeronasal receptor genes in two mouse genome assemblies.	OR7C2 OR2Z1 OR2AJ1	8.62e-04	74	87	3	15081110
Pubmed	TRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation.	PHF1 DNMT1	9.22e-04	18	87	2	28068325
Pubmed	PDGFRα controls the balance of stromal and adipogenic cells during adipose tissue organogenesis.	ZNF423 ZNF521	1.03e-03	19	87	2	28049691
Pubmed	Abnormal Wnt and PI3Kinase signaling in the malformed intestine of lama5 deficient mice.	SFRP2 FHL1	1.03e-03	19	87	2	22666383
Pubmed	Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium.	MUC2 DNMT1	1.14e-03	20	87	2	26023099
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	PHF1 ZC3H14 RC3H2 ANGEL2 ZMYM4 DNMT1	1.17e-03	469	87	6	27634302
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	HSPA4L GRK5 POLR2A WDR70 HSPA4 DNMT1	1.25e-03	475	87	6	31040226
Pubmed	Analysis of phosphorylation-dependent protein-protein interactions of histone h3.	PXN HSPA4	1.26e-03	21	87	2	25330109
Pubmed	Unravelling the transcriptional responses of TGF-β: Smad3 and EZH2 constitute a regulatory switch that controls neuroretinal epithelial cell fate specification.	PHF1 ZBTB49	1.51e-03	23	87	2	30779601
Pubmed	The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities.	HSPA4L HSPA4	1.51e-03	23	87	2	21231916
Pubmed	Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription.	POLR2A HSPA4	1.65e-03	24	87	2	10617616
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DST GRK5 ZNF335 POLR2A WDR70 PXN ATG2A ZNF236 ST14	1.78e-03	1105	87	9	35748872
Pubmed	The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling.	SFRP2 MUC2	1.79e-03	25	87	2	15809042
Pubmed	Systematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor Alpha (ERα) and Biochemical Characterization of the ERα-Hsp70 Interaction.	HSPA4L HSPA4	1.79e-03	25	87	2	27483141
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	ZC3H14 ZNF346 GRK5 POLR2A WDR70 HSPA4 DNMT1	1.90e-03	701	87	7	30196744
Pubmed	Interactome of the negative regulator of nuclear import BRCA1-binding protein 2.	ZNF521 DNMT1	1.93e-03	26	87	2	25820252
Pubmed	Distribution of olfactory receptor genes in the human genome.	OR7C2 OR2T1	2.24e-03	28	87	2	9500546
Pubmed	Modeling digits. Digit patterning is controlled by a Bmp-Sox9-Wnt Turing network modulated by morphogen gradients.	SFRP2 INHBA	2.24e-03	28	87	2	25082703
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	ZC3H14 RC3H2 ZNF346 POLA1 RC3H1 PXN FHL1	2.28e-03	724	87	7	36232890
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	ZNF346 PATZ1 POLR2A FAM76A IRF2BPL	2.40e-03	370	87	5	22922362
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	MROH9 DST POLA1 POLR2A C6 TNR DNAH14	2.50e-03	736	87	7	29676528
Cytoband	1q44	OR2T7 OR2T1 OR2T2 OR2T10 OR2AJ1	2.28e-06	110	87	5	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR2T7 OR2T1 OR2T2 OR2T10 OR2AJ1	4.79e-06	128	87	5	chr1q44
Cytoband	9q33.2	OR1L3 OR1L1 OR1L4	5.72e-05	39	87	3	9q33.2
Cytoband	Ensembl 112 genes in cytogenetic band chr9q33	RC3H2 OR1L3 OR1L1 OR1L4	1.43e-04	138	87	4	chr9q33
Cytoband	18q23	SALL3 ZNF407	1.39e-03	29	87	2	18q23
Cytoband	Ensembl 112 genes in cytogenetic band chr5p13	WDR70 CARD6 C6	2.39e-03	139	87	3	chr5p13
Cytoband	Ensembl 112 genes in cytogenetic band chr18q23	SALL3 ZNF236	2.64e-03	40	87	2	chr18q23
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF502 ZBTB49 ZNF486 ZNF497 SALL3 ZNF41 PATZ1 ZNF423 ZNF335 ZNF483 ZNF267 ZNF521 ZNF407 ZNF236 ZNF501 ZNF774	1.67e-08	718	72	16	28
GeneFamily	Olfactory receptors, family 2	OR2T7 OR2T1 OR2T2 OR2B3 OR2Z1 OR2T10 OR2AJ1	3.25e-07	113	72	7	149
GeneFamily	Zinc fingers CCCH-type	ZC3H14 RC3H2 RC3H1	3.62e-04	35	72	3	73
GeneFamily	Olfactory receptors, family 1	OR1L3 OR1L1 OR1L4	5.38e-04	40	72	3	147
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	ZBTB49 BTBD8 PATZ1 BACH1	2.01e-03	134	72	4	861
GeneFamily	Heat shock 70kDa proteins	HSPA4L HSPA4	2.05e-03	17	72	2	583
ToppCell	ICU-NoSEP-Lymphocyte-T_NK-NK_CD56bright\|ICU-NoSEP / Disease, Lineage and Cell Type	FAM117A FBXO8 ZNF236 FHL1 ZNF501 DNAH14	9.41e-07	167	87	6	f4f188a8efca8cdd0ecfb857fe4538c10847eadd
ToppCell	Sepsis-ICU-NoSEP-Lymphocyte-T/NK-NK_CD56bright\|ICU-NoSEP / Disease, condition lineage and cell class	FAM117A FBXO8 ZNF236 FHL1 ZNF501 DNAH14	2.68e-06	200	87	6	c2df917900872453ea17a39928e39d071a6d3339
Disease	neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures (implicated_via_orthology)	IRF2BP2 IRF2BP1 IRF2BPL	1.99e-08	3	81	3	DOID:0081327 (implicated_via_orthology)
Disease	central nervous system disease (implicated_via_orthology)	IRF2BP2 IRF2BP1 IRF2BPL	1.09e-05	16	81	3	DOID:331 (implicated_via_orthology)
Disease	complement component C7 measurement	CARD6 C6	4.83e-04	12	81	2	EFO_0008093
Disease	urgency urinary incontinence	ADAMTS16 ZNF521	4.83e-04	12	81	2	EFO_0006865
Disease	lysophosphatidylethanolamine 18:0 measurement	ADAMTS16 TNR	7.64e-04	15	81	2	EFO_0010367
Disease	hypertrophic cardiomyopathy (is_marker_for)	FHL1 DNMT1	9.85e-04	17	81	2	DOID:11984 (is_marker_for)
Disease	obsolete_red blood cell distribution width	TRMU IRF2BP2 FAM117A IRF2BP1 PATZ1 RC3H1 BACH1 ZNF407 USP4 SLFN14 TRIM38	1.11e-03	1347	81	11	EFO_0005192
Disease	cardiomyopathy (is_implicated_in)	TSHR POMT1	1.23e-03	19	81	2	DOID:0050700 (is_implicated_in)
Disease	diaphragmatic hernia	PHF1 ADAMTS16	1.51e-03	21	81	2	EFO_0008561
Disease	antiphospholipid syndrome	GRK5 TSHR	1.98e-03	24	81	2	EFO_0002689
Disease	fasting blood glucose measurement, HOMA-B, fasting blood insulin measurement	OR1L3 OR1L1	2.14e-03	25	81	2	EFO_0004465, EFO_0004466, EFO_0004469
Disease	breast cancer, lung cancer	TRIM38 HSPA4	2.14e-03	25	81	2	MONDO_0007254, MONDO_0008903

Protein segments in the cluster

Peptide	Gene	Start	Entry
SECIKKLCPVYFHSN	CATSPERG	341	Q6ZRH7
PRKKCFSSHCQKTDL	BACH1	141	O14867
ALPQHKLTCFSVYCK	DNMT1	401	P26358
AFLTSCPDKNKVHFN	FAM117A	361	Q9C073
KSSCLFCLPSFKSHQ	A4GNT	26	Q9UNA3
PDGCAICFKHSKFSL	ANGEL2	251	Q5VTE6
CKSAFKLANCFDLTP	ATG2A	876	Q2TAZ0
NTHFCPIAEKKDAFC	ADAMTS16	1176	Q8TE57
HSPFANLKSCCVPTK	INHBA	381	P08476
CLNKLHRKACPFDQT	RC3H2	41	Q9HBD1
CLNKLHRKACPFDQT	RC3H1	41	Q5TC82
IKSFFPHSGKDCLLC	C8orf76	201	Q96K31
ACFSKVFNGCPLKIH	MAP4K3	546	Q8IVH8
HFFCEVPALLKLSCA	OR2B3	176	O76000
HFFCEAPAVLKLACA	OR2T1	226	O43869
NHFFCEIPAVLKLSC	OR2T2	176	Q6IF00
DCEVFSKNHAAPFSK	HSPA4	416	P34932
NPDIVCNKHIKFSCF	TRMU	96	O75648
KLKDLCNDFPSHLEC	DST	3356	Q03001
HFLLQSCQPFKTACA	MAP3K6	506	O95382
HKFCFPCSRESIKAQ	IRF2BPL	736	Q9H1B7
FLPSKCCSSHKTIKQ	PID1	16	Q7Z2X4
NHFFCEVPALLKLSC	OR2T7	166	P0C7T2
HFFCEVPALLKLSCA	OR2Z1	176	Q8NG97
PKNNCTFFSCVKIHN	MUC2	5016	Q02817
TKFSHRFCACNPDLM	FBXO8	236	Q9NRD0
QDLNLCTSCHPDKFF	LACC1	396	Q8IV20
VDCEQLCSHFLFLPK	MROH9	536	Q5TGP6
SHFCVVSKPKDCIFP	POLA1	581	P09884
HFFCDDQPVLKLSCS	OR1L1	226	Q8NH94
HFFCEVPAVLKLSCS	OR2T10	176	Q8NGZ9
KFPLLNSETHIEFCC	PASD1	96	Q8IV76
LKKHSEGPSNFCSIC	PATZ1	486	Q9HBE1
PEHFVCAFCLKQLNK	PXN	556	P49023
KCRPALCTLLSHDFF	SCYL3	231	Q8IZE3
HFFCEPAQVLKVACS	OR7D4	176	Q8NG98
LKFFNCQKHSPFSLS	POMT1	171	Q9Y6A1
FRCAKCLHPLANETF	FHL1	66	Q13642
TCQHFLKCLFSTFPQ	CARD6	71	Q9BX69
FTSPACKFLAEKCLN	C6	811	P13671
FCPFLTNAHFIKLCS	EFCAB6	536	Q5THR3
FPKCENSSDCSLQKH	BTBD8	151	Q5XKL5
KEFLPFLSDSCCTLH	C1orf112	261	Q9NSG2
DLAKCALFAFKCNTA	DNAH14	1176	Q0VDD8
KPCKELFSACAQSVH	GRK5	136	P34947
ASAEDPFFKHKCRFC	SALL3	411	Q9BXA9
SHKFCFPCSRQSIKQ	IRF2BP2	526	Q7Z5L9
LSACAPFNVRFKKDH	IRF2BP1	236	Q8IU81
CHCPAKVEQTAFSFL	LRRC8D	521	Q7L1W4
HFFCEVPAMLKLSCA	OR2AJ1	176	Q8NGZ0
HFFCDPSEVLKLACS	OR7C2	176	O60412
HFFCDVNPVLKLSCS	OR1L3	176	Q8NH93
KHFFCDTQPVLKLSC	OR1L4	176	Q8NGR5
DHFICDLFPLLKLSC	OR4C5	196	Q8NGB2
FHEACTQCLSKPLLY	PHF1	211	O43189
QCHPDTKKFLCSLFA	SFRP2	86	Q96HF1
TKKFLCSLFAPVCLD	SFRP2	91	Q96HF1
CHLCITDFFKNPSQK	TRIM38	36	O00635
FHFCCEKPKVNFTTK	SLFN14	281	P0C7P3
ACTKCHQRFPFEALS	FAM76A	6	Q8TAV0
KCFQCPFTCNEKSHL	ZNF750	26	Q32MQ0
PFVCAHCSKAFVRKS	ZNF497	441	Q6ZNH5
FHGLFKSTLVCPECA	USP4	451	Q13107
ECEVFCKNHPAPFSK	HSPA4L	416	O95757
ASFKAFRSLQPCECH	WDR70	216	Q9NW82
CFFCSKLLVDSNNPK	POLR2A	111	P24928
KCKVCAKPFTCFSNL	ZNF267	521	Q14586
CKFCSKAFHAIILLE	ZNF521	811	Q96K83
EKPFHCSKCNKSFRQ	ZNF774	456	Q6NX45
GHQFTCKNKFCKPLF	ST14	491	Q9Y5Y6
HRINFPKKACPCASS	TNR	116	Q92752
ASFLKPCTLTFKHCA	UNC5CL	171	Q8IV45
ETLKVPCHFPCKFSS	PIGR	476	P01833
FPAAAAAFSLCHKKE	SKOR2	411	Q2VWA4
CPECGKAFIQKSHFI	ZNF41	651	P51814
IDPDKFCSLCHATFN	ZNF346	181	Q9UL40
CGKAFCQSPSLIKHQ	ZNF502	356	Q8TBZ5
KCNQCEKAFPTHSLL	ZNF483	636	Q8TF39
FHKCEICLLSFPKES	ZNF236	36	Q9UL36
KPHACAFCPAAFSQK	ZNF236	251	Q9UL36
KPFECNICGKHFSQA	ZBTB49	421	Q6ZSB9
NPAKAHKCIFCGETF	ZNF423	776	Q2M1K9
PFKCKICHFATAQLG	ZNF407	1566	Q9C0G0
LSHVSDKPFKCSFCP	ZNF335	641	Q9H4Z2
CKECDKAFNHPATLS	ZNF486	296	Q96H40
PNCKFAEKCLFVHPN	ZC3H14	626	Q6PJT7
KCQHCNRLFATKPEL	ZMYM4	686	Q5VZL5
CGKAFCQSPSLIKHQ	ZNF501	111	Q96CX3
DLSYPSHCCAFKNQK	TSHR	276	P16473
FCQLAAPACKHLSDA	NLRP13	876	Q86W25