Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II CTD heptapeptide repeat kinase activity	CDK12 CDK13	1.83e-04	10	41	2	GO:0008353
GeneOntologyBiologicalProcess	anterograde trans-synaptic signaling	TSC2 IGSF9B SLC24A1 KCNC3 BCR NFATC4 SIPA1L1 PCLO KIF1B ITPR3	1.32e-05	931	42	10	GO:0098916
GeneOntologyBiologicalProcess	chemical synaptic transmission	TSC2 IGSF9B SLC24A1 KCNC3 BCR NFATC4 SIPA1L1 PCLO KIF1B ITPR3	1.32e-05	931	42	10	GO:0007268
GeneOntologyBiologicalProcess	trans-synaptic signaling	TSC2 IGSF9B SLC24A1 KCNC3 BCR NFATC4 SIPA1L1 PCLO KIF1B ITPR3	1.42e-05	939	42	10	GO:0099537
GeneOntologyBiologicalProcess	cell junction organization	TSC2 SRCIN1 IGSF9B BCR NFATC4 CDHR3 RBMX SIPA1L1 PCLO CNTN5	1.95e-05	974	42	10	GO:0034330
GeneOntologyBiologicalProcess	synaptic signaling	TSC2 IGSF9B SLC24A1 KCNC3 BCR NFATC4 SIPA1L1 PCLO KIF1B ITPR3	1.98e-05	976	42	10	GO:0099536
GeneOntologyBiologicalProcess	synapse organization	TSC2 SRCIN1 IGSF9B NFATC4 RBMX SIPA1L1 PCLO CNTN5	6.17e-05	685	42	8	GO:0050808
GeneOntologyCellularComponent	postsynaptic density	TSC2 SRCIN1 IGSF9B CTNND1 BCR RBMX SIPA1L1 PCLO	2.26e-06	451	41	8	GO:0014069
GeneOntologyCellularComponent	asymmetric synapse	TSC2 SRCIN1 IGSF9B CTNND1 BCR RBMX SIPA1L1 PCLO	3.42e-06	477	41	8	GO:0032279
GeneOntologyCellularComponent	dendrite	TSC2 SRCIN1 IGSF9B CTNND1 KCNC3 BCR SIPA1L1 PCLO KIF1B ITPR3	4.53e-06	858	41	10	GO:0030425
GeneOntologyCellularComponent	dendritic tree	TSC2 SRCIN1 IGSF9B CTNND1 KCNC3 BCR SIPA1L1 PCLO KIF1B ITPR3	4.63e-06	860	41	10	GO:0097447
GeneOntologyCellularComponent	postsynaptic specialization	TSC2 SRCIN1 IGSF9B CTNND1 BCR RBMX SIPA1L1 PCLO	5.05e-06	503	41	8	GO:0099572
GeneOntologyCellularComponent	neuron to neuron synapse	TSC2 SRCIN1 IGSF9B CTNND1 BCR RBMX SIPA1L1 PCLO	6.72e-06	523	41	8	GO:0098984
GeneOntologyCellularComponent	somatodendritic compartment	TSC2 SRCIN1 IGSF9B CTNND1 SLC24A1 KCNC3 BCR SIPA1L1 PCLO KIF1B ITPR3	1.69e-05	1228	41	11	GO:0036477
GeneOntologyCellularComponent	postsynapse	TSC2 SRCIN1 IGSF9B CTNND1 KCNC3 BCR RBMX SIPA1L1 PCLO KIF1B	2.02e-05	1018	41	10	GO:0098794
GeneOntologyCellularComponent	axon	TSC2 SRCIN1 CTNND1 KCNC3 BCR CDHR3 PCLO CNTN5 KIF1B	4.57e-05	891	41	9	GO:0030424
GeneOntologyCellularComponent	adherens junction	FRMD4A SHROOM3 CTNND1 DSG3 CDHR3	5.70e-05	212	41	5	GO:0005912
GeneOntologyCellularComponent	cyclin/CDK positive transcription elongation factor complex	CDK12 CDK13	1.34e-04	9	41	2	GO:0008024
GeneOntologyCellularComponent	glutamatergic synapse	TSC2 SRCIN1 CTNND1 KCNC3 BCR RBMX SIPA1L1 PCLO	1.60e-04	817	41	8	GO:0098978
GeneOntologyCellularComponent	transcription elongation factor complex	ELOA2 CDK12 CDK13	1.81e-04	56	41	3	GO:0008023
GeneOntologyCellularComponent	neuronal cell body	TSC2 SRCIN1 IGSF9B SLC24A1 KCNC3 SIPA1L1 PCLO ITPR3	1.85e-04	835	41	8	GO:0043025
GeneOntologyCellularComponent	apical junction complex	NHS FRMD4A SHROOM3 CTNND1	2.56e-04	158	41	4	GO:0043296
GeneOntologyCellularComponent	presynapse	SRCIN1 CTNND1 KCNC3 CDHR3 PCLO CNTN5 KIF1B ITPR3	2.78e-04	886	41	8	GO:0098793
GeneOntologyCellularComponent	cell body	TSC2 SRCIN1 IGSF9B SLC24A1 KCNC3 SIPA1L1 PCLO ITPR3	3.82e-04	929	41	8	GO:0044297
GeneOntologyCellularComponent	anchoring junction	CASS4 NHS FRMD4A SHROOM3 SRCIN1 CTNND1 DSG3 CDHR3	5.31e-04	976	41	8	GO:0070161
GeneOntologyCellularComponent	nuclear cyclin-dependent protein kinase holoenzyme complex	CDK12 CDK13	5.63e-04	18	41	2	GO:0019908
GeneOntologyCellularComponent	presynaptic active zone cytoplasmic component	CTNND1 PCLO	9.25e-04	23	41	2	GO:0098831
GeneOntologyCellularComponent	cell-cell junction	NHS FRMD4A SHROOM3 CTNND1 DSG3 CDHR3	9.64e-04	591	41	6	GO:0005911
GeneOntologyCellularComponent	carboxy-terminal domain protein kinase complex	CDK12 CDK13	1.01e-03	24	41	2	GO:0032806
GeneOntologyCellularComponent	extrinsic component of membrane	JAK3 CTNND1 ZFYVE1 CDHR3	1.05e-03	230	41	4	GO:0019898
GeneOntologyCellularComponent	dendritic spine	CTNND1 KCNC3 BCR SIPA1L1	1.27e-03	242	41	4	GO:0043197
GeneOntologyCellularComponent	neuron spine	CTNND1 KCNC3 BCR SIPA1L1	1.37e-03	247	41	4	GO:0044309
GeneOntologyCellularComponent	distal axon	TSC2 CTNND1 KCNC3 CDHR3 PCLO	1.54e-03	435	41	5	GO:0150034
GeneOntologyCellularComponent	inhibitory synapse	IGSF9B PCLO	1.68e-03	31	41	2	GO:0060077
GeneOntologyCellularComponent	catenin complex	CTNND1 CDHR3	1.79e-03	32	41	2	GO:0016342
GeneOntologyCellularComponent	bicellular tight junction	NHS FRMD4A CTNND1	2.15e-03	131	41	3	GO:0005923
GeneOntologyCellularComponent	extrinsic component of plasma membrane	JAK3 CTNND1 CDHR3	2.45e-03	137	41	3	GO:0019897
GeneOntologyCellularComponent	tight junction	NHS FRMD4A CTNND1	2.55e-03	139	41	3	GO:0070160
GeneOntologyCellularComponent	cell cortex region	CTNND1 PCLO	3.52e-03	45	41	2	GO:0099738
GeneOntologyCellularComponent	GABA-ergic synapse	IGSF9B PCLO CNTN5	4.06e-03	164	41	3	GO:0098982
GeneOntologyCellularComponent	postsynaptic density, intracellular component	CTNND1 BCR	4.16e-03	49	41	2	GO:0099092
GeneOntologyCellularComponent	cytoplasmic region	SPATA7 CTNND1 PCLO KIF1B	5.30e-03	360	41	4	GO:0099568
GeneOntologyCellularComponent	postsynaptic specialization, intracellular component	CTNND1 BCR	5.41e-03	56	41	2	GO:0099091
GeneOntologyCellularComponent	organelle membrane contact site	ZFYVE1 IMMT	5.60e-03	57	41	2	GO:0044232
GeneOntologyCellularComponent	cell cortex	SHROOM3 CTNND1 KCNC3 PCLO	5.89e-03	371	41	4	GO:0005938
GeneOntologyCellularComponent	cyclin-dependent protein kinase holoenzyme complex	CDK12 CDK13	6.38e-03	61	41	2	GO:0000307
GeneOntologyCellularComponent	axon terminus	KCNC3 CDHR3 PCLO	8.05e-03	210	41	3	GO:0043679
GeneOntologyCellularComponent	nuclear speck	NFATC4 SRSF9 CDK12 CDK13	9.89e-03	431	41	4	GO:0016607
GeneOntologyCellularComponent	lamellipodium	NHS SRCIN1 CTNND1	1.03e-02	230	41	3	GO:0030027
GeneOntologyCellularComponent	neuron projection terminus	KCNC3 CDHR3 PCLO	1.07e-02	233	41	3	GO:0044306
GeneOntologyCellularComponent	growth cone	TSC2 CTNND1 PCLO	1.22e-02	245	41	3	GO:0030426
MousePheno	midline facial cleft	SP8 SHROOM3 CDK13	1.61e-05	19	37	3	MP:0000108
MousePheno	increased vertical activity	TSC2 IGSF9B KCNC3 SRSF9 SIPA1L1 KIF1B	4.50e-05	250	37	6	MP:0002574
Domain	NHS_fam	NHSL1 NHS	4.94e-06	2	42	2	IPR024845
Domain	NHS	NHSL1 NHS	4.94e-06	2	42	2	PF15273
Domain	Rap_GAP	TSC2 SIPA1L1	2.20e-04	10	42	2	PF02145
Domain	Rap_GAP_dom	TSC2 SIPA1L1	2.68e-04	11	42	2	IPR000331
Domain	RAPGAP	TSC2 SIPA1L1	2.68e-04	11	42	2	PS50085
Domain	PDZ	SHROOM3 SIPA1L1 PCLO	4.72e-03	151	42	3	PS50106
Domain	PDZ	SHROOM3 SIPA1L1 PCLO	4.81e-03	152	42	3	IPR001478
Domain	FERM_domain	JAK3 FRMD4A	5.43e-03	49	42	2	IPR000299
Domain	FERM_1	JAK3 FRMD4A	5.65e-03	50	42	2	PS00660
Domain	FERM_2	JAK3 FRMD4A	5.65e-03	50	42	2	PS00661
Domain	Band_41_domain	JAK3 FRMD4A	5.65e-03	50	42	2	IPR019749
Domain	B41	JAK3 FRMD4A	5.65e-03	50	42	2	SM00295
Domain	FERM_3	JAK3 FRMD4A	5.65e-03	50	42	2	PS50057
Domain	Ig_2	IGSF9B CNTN5	1.17e-02	73	42	2	PF13895
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	NHSL1 SRCIN1 CTNND1 ZFYVE1 IMMT SIPA1L1 PCLO KIF1B	2.06e-10	218	42	8	33378226
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	JAK3 NHSL1 SPHK2 TSC2 SHROOM3 NUP188 BCR CDK12 CDK13 RNF43 ITPR3	5.50e-08	1105	42	11	35748872
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	NHSL1 NHS CTNND1 BCR MTUS1 SIPA1L1	1.92e-07	209	42	6	36779422
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	NHSL1 NHS TSC2 SHROOM3 CTNND1 BCR MTUS1 SIPA1L1 KIF1B	7.18e-07	861	42	9	36931259
Pubmed	Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression.	CDK12 CDK13	1.42e-06	2	42	2	24999027
Pubmed	Identification of the gene for Nance-Horan syndrome (NHS).	NHSL1 NHS	1.42e-06	2	42	2	15466011
Pubmed	Dual Inhibition of CDK12/CDK13 Targets Both Tumor and Immune Cells in Ovarian Cancer.	CDK12 CDK13	1.42e-06	2	42	2	35857807
Pubmed	Human CDK12 and CDK13, multi-tasking CTD kinases for the new millenium.	CDK12 CDK13	1.42e-06	2	42	2	30319007
Pubmed	P120-catenin is a novel desmoglein 3 interacting partner: identification of the p120-catenin association site of desmoglein 3.	CTNND1 DSG3	1.42e-06	2	42	2	18343367
Pubmed	Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processing.	CDK12 CDK13	1.42e-06	2	42	2	25561469
Pubmed	CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1.	CDK12 CDK13	1.42e-06	2	42	2	20952539
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SHROOM3 SRCIN1 NUP188 BCR MTUS1 ZFYVE1 CDK12	3.08e-06	529	42	7	14621295
Pubmed	The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by Regulating SRSF9-Mediated Splicing of NFATc4.	NFATC4 SRSF9	4.27e-06	3	42	2	38810124
Pubmed	CDK12/13 promote splicing of proximal introns by enhancing the interaction between RNA polymerase II and the splicing factor SF3B1.	CDK12 CDK13	4.27e-06	3	42	2	37026485
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	NHSL1 SRCIN1 CTNND1 ABLIM2 BCR IMMT RBMX SIPA1L1 PCLO KIF1B	5.95e-06	1431	42	10	37142655
Pubmed	The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.	CDK12 CDK13	8.53e-06	4	42	2	22012619
Pubmed	Catenin delta-1 (CTNND1) phosphorylation controls the mesenchymal to epithelial transition in astrocytic tumors.	TSC2 CTNND1	8.53e-06	4	42	2	27516388
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	TSC2 SRCIN1 ABLIM2 SIPA1L1 PCLO	8.62e-06	231	42	5	16452087
Pubmed	The DNA sequence and analysis of human chromosome 14.	SPATA7 VIPAS39 ZFYVE1 SIPA1L1	1.00e-05	111	42	4	12508121
Pubmed	Cyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cells.	CDK12 CDK13	1.42e-05	5	42	2	22547058
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	TSC2 SHROOM3 VIPAS39 NFATC4 SIPA1L1 KIF1B	1.53e-05	446	42	6	24255178
Pubmed	Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the Spinophilin/Neurofilament Medium Interaction.	SRCIN1 BCR RBMX PCLO	1.93e-05	131	42	4	28634551
Pubmed	Lens placode planar cell polarity is dependent on Cdc42-mediated junctional contraction inhibition.	SHROOM3 CTNND1	2.98e-05	7	42	2	26902112
Pubmed	The STAR/GSG family protein rSLM-2 regulates the selection of alternative splice sites.	SRSF9 RBMX	2.98e-05	7	42	2	11118435
Pubmed	The tumor-suppressor function of E-cadherin.	CTNND1 DSG3	2.98e-05	7	42	2	9837810
Pubmed	p120-catenin-dependent junctional recruitment of Shroom3 is required for apical constriction during lens pit morphogenesis.	SHROOM3 CTNND1	3.97e-05	8	42	2	25038041
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	NHSL1 FRMD4A SRCIN1 VIPAS39 CTNND1 BCR SIPA1L1 PCLO	5.66e-05	1139	42	8	36417873
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	SRCIN1 CTNND1 ABLIM2 SIPA1L1 PCLO	6.03e-05	347	42	5	17114649
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	TSC2 VIPAS39 NUP188 SRSF9 CDK13 IMMT RBMX PCLO ITPR3	6.07e-05	1496	42	9	32877691
Pubmed	Cyclin-dependent kinases: a family portrait.	CDK12 CDK13	9.32e-05	12	42	2	19884882
Pubmed	The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium.	CTNND1 KIF1B	9.32e-05	12	42	2	15834408
Pubmed	Defining desmosomal plakophilin-3 interactions.	CTNND1 DSG3	9.32e-05	12	42	2	12707304
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	IGSF9B NUP188 CTNND1 BCR NFATC4 CDK12 CDK13	9.96e-05	910	42	7	36736316
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	NHS CTNND1 SRSF9 IMMT RBMX SIPA1L1 KIF1B ITPR3	1.06e-04	1247	42	8	27684187
Pubmed	RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing.	SRSF9 RBMX	1.10e-04	13	42	2	10749975
Pubmed	Docking motif-guided mapping of the interactome of protein phosphatase-1.	TSC2 ZFYVE1 ITPR3	1.26e-04	80	42	3	19389623
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	NUP188 CTNND1 SRSF9 IMMT RBMX ITPR3	1.34e-04	660	42	6	32780723
Pubmed	Neural defects caused by total and Wnt1-Cre mediated ablation of p120ctn in mice.	SHROOM3 CTNND1	1.48e-04	15	42	2	32741376
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FRMD4A CTNND1 PCLO	1.62e-04	87	42	3	12465718
Pubmed	The protein interaction landscape of the human CMGC kinase group.	NUP188 SRSF9 CDK12 CDK13 RBMX SIPA1L1	1.77e-04	695	42	6	23602568
Pubmed	Transcriptional Repression of Aerobic Glycolysis by OVOL2 in Breast Cancer.	CTNND1 IMMT SIPA1L1	2.10e-04	95	42	3	35896951
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PPM1M NHSL1 NHS VIPAS39 CTNND1 MTUS1 ITPR3	2.39e-04	1049	42	7	27880917
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	VIPAS39 CTNND1 BCR SIPA1L1	2.39e-04	251	42	4	29778605
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SRSF9 CDK12 CDK13 RBMX SIPA1L1 KIF1B	3.16e-04	774	42	6	15302935
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	NHS SRSF9 CDK12 CDK13 RBMX	3.39e-04	503	42	5	16964243
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	TSC2 VIPAS39 CTNND1 IMMT ITPR3	3.42e-04	504	42	5	34432599
Pubmed	Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.	JAK3 SPHK2 TSC2 CDK12	3.43e-04	276	42	4	28319085
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	SHROOM3 SRCIN1 IGSF9B CTNND1 ABLIM2 BCR CDK13 KIF1B	3.56e-04	1489	42	8	28611215
Pubmed	DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC.	CTNND1 SRSF9 SIPA1L1	3.97e-04	118	42	3	37105989
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	CASS4 IMMT RBMX	4.17e-04	120	42	3	31413325
Pubmed	The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.	SHROOM3 RBMX SIPA1L1	4.70e-04	125	42	3	29467281
Pubmed	Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord.	BCR KIF1B	4.90e-04	27	42	2	19026994
Pubmed	Identification of 14-3-3epsilon substrates from embryonic murine brain.	FRMD4A SRCIN1 CTNND1	5.51e-04	132	42	3	16944949
Pubmed	Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.	BCR CDK13 RBMX	5.63e-04	133	42	3	15144186
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	NHSL1 NHS SHROOM3 SRCIN1 CTNND1	5.76e-04	565	42	5	25468996
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	CTNND1 DSG3 SRSF9 IMMT RBMX SIPA1L1 ITPR3	7.06e-04	1257	42	7	36526897
Pubmed	RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition.	NUP188 SRSF9 RNF43	7.68e-04	148	42	3	35676246
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	SRCIN1 IMMT SIPA1L1 PCLO KIF1B	8.80e-04	621	42	5	22794259
Pubmed	Generation and analysis of 280,000 human expressed sequence tags.	VIPAS39 ADARB2 IMMT RBMX	1.00e-03	368	42	4	8889549
Pubmed	Transcriptional network orchestrating regional patterning of cortical progenitors.	SP8 NFATC4	1.03e-03	39	42	2	34921112
Interaction	TOP3B interactions	JAK3 NHSL1 SPHK2 TSC2 SHROOM3 NUP188 BCR SRSF9 CDK12 CDK13 IMMT RNF43 KIF1B ITPR3	6.14e-07	1470	41	14	int:TOP3B
Interaction	YWHAB interactions	NHSL1 NHS TSC2 SHROOM3 VIPAS39 CTNND1 BCR RNF43 RBMX SIPA1L1 KIF1B	3.89e-06	1014	41	11	int:YWHAB
Interaction	YWHAG interactions	NHSL1 NHS FRMD4A PPIP5K1 TSC2 SHROOM3 CTNND1 BCR MTUS1 CDK12 SIPA1L1 KIF1B	4.44e-06	1248	41	12	int:YWHAG
Interaction	YWHAE interactions	NHS FRMD4A TSC2 SHROOM3 SRCIN1 CTNND1 BCR CDK12 CDK13 RNF43 SIPA1L1 KIF1B	4.74e-06	1256	41	12	int:YWHAE
Interaction	YWHAQ interactions	NHSL1 NHS TSC2 SHROOM3 CTNND1 BCR MTUS1 NFATC4 RNF43 SIPA1L1 KIF1B	9.87e-06	1118	41	11	int:YWHAQ
Interaction	VASP interactions	NHSL1 NHS SHROOM3 BCR SRSF9 SIPA1L1	2.68e-05	294	41	6	int:VASP
Interaction	YWHAH interactions	NHSL1 NHS FRMD4A TSC2 SHROOM3 CTNND1 BCR MTUS1 SIPA1L1 KIF1B	5.44e-05	1102	41	10	int:YWHAH
Interaction	SFN interactions	NHS TSC2 SHROOM3 BCR MTUS1 RBMX SIPA1L1 KIF1B	6.50e-05	692	41	8	int:SFN
Interaction	CTNNA1 interactions	NHSL1 NHS SRCIN1 CTNND1 BCR SIPA1L1	6.75e-05	347	41	6	int:CTNNA1
Cytoband	14q24.2	ZFYVE1 SIPA1L1	2.42e-04	25	42	2	14q24.2
Cytoband	Ensembl 112 genes in cytogenetic band chr14q24	VIPAS39 ZFYVE1 SIPA1L1	8.25e-04	200	42	3	chr14q24
GeneFamily	Cyclin dependent kinases	CDK12 CDK13	7.88e-04	26	29	2	496
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	BCR PCLO	1.51e-03	36	29	2	823
GeneFamily	PDZ domain containing	SHROOM3 SIPA1L1 PCLO	1.81e-03	152	29	3	1220
Coexpression	BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN	SPATA7 SHROOM3 ZFYVE1 RNF43	1.20e-05	88	42	4	M2232
Coexpression	XIE_TRASTUZUMAB_CARDIOTOXICITY_CIRCRNA_GENES	PPIP5K1 MTUS1 CDK13	3.63e-05	40	42	3	MM17488
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 NHS MTUS1 ADARB2 CNTN5	9.80e-07	191	42	5	764c3a8829ae1253a0790744138266e81fc075ec
ToppCell	3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SHROOM3 SRCIN1 CDHR3 CNTN5	2.63e-05	183	42	4	58847e8f3a7ce3e33adba9477bcd55e769a64a90
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 NHS ADARB2 CNTN5	2.74e-05	185	42	4	16e9ccea0e3b95d90dc48ef74206c805681dac0b
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABLIM2 SLC24A1 BCR PCLO	2.74e-05	185	42	4	241ea1e178fffef9e7df971de739e794332d5173
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_PRSS8\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 NHS ADARB2 CNTN5	2.74e-05	185	42	4	4c42bd3cd72f91f4d4ebb849069a03761a2cd662
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NHSL1 SHROOM3 MTUS1 ITPR3	3.10e-05	191	42	4	ca5669bd6f4a17471acae3eb229f845cc2e08efa
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SHROOM3 MTUS1 PCLO ITPR3	3.17e-05	192	42	4	cc9911e182a289779a2612bc213daae5607689e7
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 NHS MTUS1 ADARB2	3.17e-05	192	42	4	3abee376c37c3646da33ac381aa63d50a01607a6
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NHS MTUS1 ADARB2 CNTN5	3.23e-05	193	42	4	9f9eb241b0b82a6f12de6921c3acf6fed7cf65bb
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SP8 NHS ADARB2 CNTN5	3.72e-05	200	42	4	d0167f96314be78b6d867bbcc6e4396071d931b8
ToppCell	Neuronal-Inhibitory-iA\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SP8 NHS MTUS1 ADARB2	3.72e-05	200	42	4	5ef4a3dc18a44292184a59ced916183c0699b01e
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SP8 NHS MTUS1 ADARB2	3.72e-05	200	42	4	75649534a98bc738fca62d071de0978dc61eb24f
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_monocytic-monocyte\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	FRMD4A CTNND1 MTUS1	2.22e-04	125	42	3	a72891c3fb9cdefa9254f8e2e3c4ffa6fc3a5ffc
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT1\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM3 MTUS1 RNF43	2.33e-04	127	42	3	5b0adbcafad31a6759c9bdce2f7f9591a8edc450
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Fam19a1_Pax6\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SP8 NHS ADARB2	2.49e-04	130	42	3	60e28d452d0e2af768459ba8dbe998117c94a251
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM3 MTUS1 RNF43	2.66e-04	133	42	3	5bf5e654653e2c340891f51e3f2a30441b7b6b2b
ToppCell	PBMC-Mild-cDC_7\|Mild / Compartment, Disease Groups and Clusters	TNFRSF10D CDHR3 ITPR3	3.23e-04	142	42	3	58f66f35646f281e64d634e6c26adbd1d4e6c830
ToppCell	3'_v3-Lung-Lymphocytic_T_CD4-Tnaive/CM_CD4_activated\|Lung / Manually curated celltypes from each tissue	SPHK2 IGSF9B ITPR3	3.86e-04	151	42	3	9bfb807e1180b31fa9a2c500ce993de9707c070f
ToppCell	LPS_only-Epithelial_alveolar-AT_1-AT2_Progenitor\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM3 MTUS1 RNF43	4.02e-04	153	42	3	e7a074ea8232bacf924be78a244a8507c7e1ebc8
ToppCell	367C-Lymphocytic-ILC-ILC-3\|367C / Donor, Lineage, Cell class and subclass (all cells)	PPIP5K1 CDK12 ITPR3	4.02e-04	153	42	3	9d64aadbb4bb28469af1d728457b431e21577429
ToppCell	TCGA-Thryoid-Solid_Tissue_Normal-Thryoid_normal_tissue-Thryoid_normal_tissue-3\|TCGA-Thryoid / Sample_Type by Project: Shred V9	IGSF9B CDHR3 CNTN5	4.09e-04	154	42	3	4e9203c220a44c70cd7979796a0b461991422257
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SP8 NHS ADARB2	4.17e-04	155	42	3	105d59d8a1bb8cb37eef2c1767d737b2108ac7c5
ToppCell	10x5'-Liver-Myeloid_Mac-Intestinal_macrophages\|Liver / Manually curated celltypes from each tissue	NHS FRMD4A KCNC3	4.25e-04	156	42	3	9a897fc79c4fae94c5f2e9012d65297f9225e5e3
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRMD4A IGSF9B ABLIM2	4.25e-04	156	42	3	abf9dd075b1ca8f613c660cc82f8a5af071fb6ab
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRMD4A IGSF9B ABLIM2	4.25e-04	156	42	3	dd41ed918b07fa248da458a629b3c53cb7ea8764
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	JAK3 PCLO CNTN5	4.25e-04	156	42	3	10d191e29b16cae8238e8df6c0ff38882253f34e
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Tubular-6\|TCGA-Stomach / Sample_Type by Project: Shred V9	SHROOM3 NUP188 ITPR3	4.49e-04	159	42	3	655c0749c238bd68cb797adb83e25a23b8a3cc9d
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SP8 NHS ADARB2	4.49e-04	159	42	3	7f29f9dcf25ffa1822b137c571e9ac16defc6292
ToppCell	Control-Stromal-Pericyte\|Stromal / Disease state, Lineage and Cell class	ABLIM2 KCNC3 ADARB2	4.49e-04	159	42	3	6f50c381cd8a26a5a90bf0ce909713cea96910d7
ToppCell	PND07-Endothelial-Endothelial_lymphatic\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ABLIM2 SLC24A1 BCR	4.66e-04	161	42	3	133b4fadb499e842c19f573f9cf09ce08c1d4813
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ABLIM2 SLC24A1 BCR	4.66e-04	161	42	3	cb177ca10d848d0e25399ab5ebfcde1071fb94c2
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ABLIM2 SLC24A1 BCR	4.66e-04	161	42	3	9466b8658244116f8d21f2f88fb8c2d184b1bdf2
ToppCell	367C-Lymphocytic-ILC-ILC-3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	PPIP5K1 CDK12 ITPR3	4.66e-04	161	42	3	8de421c61f4d5a6e05fdb20e4d230e2db98ee4d5
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ABLIM2 SLC24A1 BCR	4.75e-04	162	42	3	96c6e94a10b124a1d25dcd705ec5aaa8609c1089
ToppCell	Posterior_cortex-Neuronal-Inhibitory\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SP8 NHS ADARB2	5.18e-04	167	42	3	9a84f45345c75f2c8ff38a04245aadee2a26a240
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-medium_spiny_neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGSF9B SLC24A1 CNTN5	5.27e-04	168	42	3	b96a48552f4236a95bbcdce2f1b05041086d7101
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-SPN_Neuron_STR\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGSF9B SLC24A1 CNTN5	5.27e-04	168	42	3	b87fc63f9e35dfcfc46cb129ea569e73c5e018bb
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SP8 NHS ADARB2	5.37e-04	169	42	3	c135d7ae0490d0024e0f4bd8c4ad42f6674a61da
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SP8 DSG3 ADARB2	5.46e-04	170	42	3	2d880223d01bde4bf777bd6f50b7d2768489075f
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SHROOM3 SRCIN1 MTUS1	5.46e-04	170	42	3	a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SP8 DSG3 ADARB2	5.46e-04	170	42	3	0cc20322cb3e3e7bbd4daad8785c99f80e355c16
ToppCell	Control-Fibroblasts-Pericytes\|Control / group, cell type (main and fine annotations)	FRMD4A ABLIM2 ADARB2	5.55e-04	171	42	3	080003f698f867935c2bfc55d241d3650f45a0ab
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SHROOM3 CTNND1 CDHR3	5.74e-04	173	42	3	8ac2e9d39c0f76e674f8bd59d1da246bab4867c8
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NHSL1 SHROOM3 RNF43	5.74e-04	173	42	3	b799c06a6a5754668e789f70c0c8bc1508568575
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Lymphocytic-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPIP5K1 SRCIN1 IGSF9B	5.84e-04	174	42	3	6987fe7959afce347282f632abc16d800ccab7c4
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Myeloid-Lymphoid_DC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SRCIN1 IGSF9B KCNC3	5.84e-04	174	42	3	16204ff504b7b382b4d90ca35003ad5336020e07
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NHS PPIP5K1 RNF43	5.84e-04	174	42	3	42f2ba54b4ea4c62482582b0ccdadffae0a5eb4a
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-AT2_Progenitor\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM3 MTUS1 RNF43	5.84e-04	174	42	3	d0e3d15731de6c19c232e3aa492c39d8151cf4ed
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABLIM2 BCR PCLO	5.94e-04	175	42	3	f6e1d7297a4dbb38e1ab4f738d91f0e62abaee69
ToppCell	COVID-19-kidney-Distal_Epi_Doublet_(PCT)\|kidney / Disease (COVID-19 only), tissue and cell type	SHROOM3 RNF43 PCLO	6.04e-04	176	42	3	36f77d878a53b30465b0dea8333a3865dba75613
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_SSTR1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 NHS ADARB2	6.14e-04	177	42	3	fdab7b7ddfb06f913b8224c0c80574dc3cf4cbd4
ToppCell	COVID-19-kidney-PCT-S1/S2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	NHS CDHR3 PCLO	6.24e-04	178	42	3	23a12d3d971b857d5be8e907334d1f6b49eeeb32
ToppCell	RV-11._Adipocyte\|RV / Chamber and Cluster_Paper	NHS FRMD4A PPIP5K1	6.24e-04	178	42	3	278bbea5cf8f0589f71675c7a3d00679391b5253
ToppCell	facs-Marrow-KLS-24m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPATA7 NUP188 CTNND1	6.34e-04	179	42	3	5297f7459b40ca780a1983fecc1bb9c035c7677e
ToppCell	ILEUM-non-inflamed-(7)_Lymphatics\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	SLC24A1 MTUS1 PCLO	6.34e-04	179	42	3	99777a8931356d1206b8ab22aaa1b1d5a600b809
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SP8 CDHR3 PCLO	6.34e-04	179	42	3	f2e8fc975c30992611630197b79daaeef7c4211d
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM3 MTUS1 RNF43	6.34e-04	179	42	3	fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCell	human_hepatoblastoma-Tumor_cells-T6\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	CASS4 NHS FRMD4A	6.34e-04	179	42	3	14fc8ccb6b215063d747643f47d780d2b237eb67
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NHS MTUS1 CNTN5	6.34e-04	179	42	3	3b0f8781232e1d42b6f8913bc989a14b3f978e79
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM3 MTUS1 RNF43	6.45e-04	180	42	3	b798a3fa2dd15b68aa4267f665559527043dcc07
ToppCell	facs-Lung-EPCAM-24m-Myeloid-Dendritic_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPIP5K1 SHROOM3 SLC24A1	6.45e-04	180	42	3	5b7d2336ed09d07f6b8dd91c1fa9c5ade633c104
ToppCell	facs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PPIP5K1 SHROOM3 SLC24A1	6.45e-04	180	42	3	d33bb00f2b7d07dda9015cb8eafd742c2b2e9ace
ToppCell	COVID-19-kidney-PCT-S2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	NHS CDHR3 PCLO	6.45e-04	180	42	3	358923e4228035a3e90e2957392089219e90dcd7
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NHS MTUS1 CNTN5	6.55e-04	181	42	3	153709b4dd3d81e09f251fa8765b58bed1932fda
ToppCell	LPS_only-Epithelial_alveolar-AT_2-AT2_Progenitor\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM3 MTUS1 RNF43	6.55e-04	181	42	3	0513b9e6673ff7bf8e72ba123ca3794b65d10170
ToppCell	367C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	SLC24A1 MTUS1 PCLO	6.55e-04	181	42	3	b244ecaa442bbef51289d8ec574ef08fa9e96318
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRMD4A KCNC3 CNTN5	6.55e-04	181	42	3	071f9bb5d39070cdc473d9b0e094d196bc702b56
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NHS ADARB2 CNTN5	6.55e-04	181	42	3	2f3d04d22d4ac016e61709ea5af3d48885c946c4
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 MTUS1 ADARB2	6.55e-04	181	42	3	35bcdcd2651149692e5b150e887c0f450c81d2d4
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_MT1G\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NHSL1 NFATC4 RNF43	6.55e-04	181	42	3	0c3f469bed108994ed696230e3c30343f7a301d3
ToppCell	COVID-19-kidney-Stressed_PCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	NHS CDHR3 PCLO	6.55e-04	181	42	3	6980ea624151da32b7f537f263e40fcb87a02e81
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-6_VIP_RGS16\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 MTUS1 ADARB2	6.55e-04	181	42	3	6c55985e464cb0f5fb3362e9fd90351b671950f7
ToppCell	367C-Endothelial_cells-Endothelial-F_(Lymphatics)\|367C / Donor, Lineage, Cell class and subclass (all cells)	SLC24A1 MTUS1 PCLO	6.55e-04	181	42	3	dd79de8098edb385a0f85d0e9621503cdf76ec43
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 MTUS1 ADARB2	6.66e-04	182	42	3	3d7a8d2ee2137b098248597058974ef5ae09c19e
ToppCell	pdx-Tumor_cells-T6\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	CASS4 NHS FRMD4A	6.66e-04	182	42	3	7b24a4f712e1ae1525e8f1c8ec4e1fc43489cbee
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 NHS ADARB2	6.66e-04	182	42	3	420a8fd30543e37a66ba0786215d056d308660d0
ToppCell	LPS_only-Epithelial_alveolar-AT_2-AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM3 MTUS1 RNF43	6.66e-04	182	42	3	d1a1feef318062f25493355d7beee8e5fb0e4206
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADARB2 CDHR3 ITPR3	6.76e-04	183	42	3	f8b636391f752e379a5c5575fd898bdf0907a3b8
ToppCell	LA-11._Adipocyte\|World / Chamber and Cluster_Paper	NHS FRMD4A PPIP5K1	6.76e-04	183	42	3	b177be283e1553fb1f69a346f1ba79ad00297fa2
ToppCell	LPS_only-Epithelial_alveolar-AT_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM3 MTUS1 RNF43	6.76e-04	183	42	3	e972432dd4d1bd31bb0982f4df3061e5e152658f
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NHS ADARB2 CNTN5	6.76e-04	183	42	3	5e361be3ae3fe05098968e58427630127bd12675
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZFTA FAM174C KCNC3	6.76e-04	183	42	3	3ef9ac1ae13b6172f9121ab1c129ecaa0fef460f
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-SST-MGE1-3\|World / Primary Cells by Cluster	SP8 MTUS1 ADARB2	6.87e-04	184	42	3	907ba412166bcb0526c5be0b06a76b6bd37c5a35
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM3 MTUS1 RNF43	6.87e-04	184	42	3	cdf6f1c6cce97a7effa0c55959652e2c0b6992b3
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM3 MTUS1 RNF43	6.87e-04	184	42	3	42ce855b4f8475a8298192feec785bdc69bc5bb0
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-AT2_Progenitor\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM3 MTUS1 RNF43	6.87e-04	184	42	3	7cc5796557379c3d1db078c1aeda40659c6e401c
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM3 MTUS1 RNF43	6.87e-04	184	42	3	ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM3 MTUS1 RNF43	6.98e-04	185	42	3	fefaf227d89f680d6f3e91c4a94e26ab4d0dc6c3
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NHS ADARB2 CNTN5	6.98e-04	185	42	3	487fa382232564f075960899d50afa0edae5d258
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2-AT2_Progenitor\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM3 MTUS1 RNF43	6.98e-04	185	42	3	929b68b05b7686341329ac756d7df172cb4b810b
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 NHS ADARB2	6.98e-04	185	42	3	79cff4f3c6ae8e5ea60e8eae082b9275f2679ee9
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 NHS ADARB2	6.98e-04	185	42	3	cefd81adb480c027545a5c78dcd05669783717f4
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FRMD4A SRCIN1 ABLIM2	6.98e-04	185	42	3	34fcfd635c828dad9643bbf1c908d79282d6f5d9
ToppCell	ILEUM-inflamed-(7)_Lymphatics\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	SLC24A1 MTUS1 PCLO	6.98e-04	185	42	3	d711dd2e91cfee723dae1ccb2b910b8cf3becc3b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FRMD4A SRCIN1 ABLIM2	6.98e-04	185	42	3	8816f2909ed11833ff3d0ed96b9cb6d6fe9e1578
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NHSL1 NFATC4 RNF43	7.09e-04	186	42	3	73cf266aeecd3cc15e8cb6094588a393bca8fbe6
ToppCell	LPS_only-Epithelial_alveolar\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM3 MTUS1 RNF43	7.09e-04	186	42	3	e0a2ea4b46af742bc7c9b2072bb85e27d5c92712
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_PRSS8\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 ADARB2 CNTN5	7.09e-04	186	42	3	fef543f188edb0d1704d9c6ace366a0f8017bf53
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NHS SHROOM3 CDHR3	7.09e-04	186	42	3	b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM3 MTUS1 RNF43	7.09e-04	186	42	3	4e94158db52df41d71e67b02b9895a358eebee0f
Computational	Neighborhood of JAK3	JAK3 IGSF9B SLC24A1 CDK13	7.68e-05	96	26	4	MORF_JAK3
Drug	0173570-0000 [211245-44-2]; Up 200; 10uM; MCF7; HT_HG-U133A	FRMD4A TNFRSF10D SLC24A1 DSG3 PCLO	2.74e-05	193	42	5	4712_UP
Drug	Heliotrine [303-33-3]; Up 200; 12.8uM; HL60; HT_HG-U133A	CTNND1 SLC24A1 NFATC4 PCLO ITPR3	2.81e-05	194	42	5	2180_UP
Drug	Carbachol [51-83-2]; Up 200; 21.8uM; HL60; HT_HG-U133A	JAK3 TNFRSF10D SLC24A1 MTUS1 DSG3	2.95e-05	196	42	5	3042_UP
Drug	Medrysone [2668-66-8]; Up 200; 11.6uM; MCF7; HT_HG-U133A	JAK3 FRMD4A ELOA2 NFATC4 PCLO	3.02e-05	197	42	5	4727_UP
Drug	Altretamine [654-05-6]; Up 200; 19uM; HL60; HT_HG-U133A	FRMD4A CTNND1 SLC24A1 MTUS1 DSG3	3.02e-05	197	42	5	3090_UP
Drug	Gabapentin [60142-96-3]; Down 200; 23.4uM; HL60; HT_HG-U133A	CASS4 ELOA2 CTNND1 SLC24A1 MTUS1	3.17e-05	199	42	5	2731_DN
Drug	borate	ZFYVE1 DSG3 CDK13 ITPR3	3.19e-05	98	42	4	CID000007628
Drug	23 B	JAK3 MTUS1 CDK13	4.71e-05	38	42	3	CID000011060
Drug	silicone fluid	DSG3 IMMT	4.96e-05	6	42	2	CID000075410
Disease	susceptibility to strep throat measurement	ADARB2 CDK13 PCLO	1.75e-04	76	42	3	EFO_0008408
Disease	hemifacial microsomia	FRMD4A SHROOM3	3.33e-04	19	42	2	MONDO_0015398
Disease	Neoplasm of uncertain or unknown behavior of ovary	CDK12 RNF43	7.84e-04	29	42	2	C0496920
Disease	Ovarian Carcinoma	CDK12 RNF43	8.39e-04	30	42	2	C0029925
Disease	autism spectrum disorder (implicated_via_orthology)	TSC2 CTNND1 ITPR3	1.33e-03	152	42	3	DOID:0060041 (implicated_via_orthology)
Disease	disease progression measurement, Crohn's disease	CDHR3 CNTN5	2.05e-03	47	42	2	EFO_0000384, EFO_0008336
Disease	major depressive episode	RBMX CNTN5	2.05e-03	47	42	2	EFO_0007634
Disease	hepatocellular carcinoma (is_implicated_in)	CDK13 RNF43 KIF1B	2.19e-03	181	42	3	DOID:684 (is_implicated_in)
Disease	depressive symptom measurement, stressful life event measurement	FRMD4A PCLO	2.32e-03	50	42	2	EFO_0007006, EFO_0007781
Disease	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	JAK3 BCR	2.60e-03	53	42	2	C1961099
Disease	interleukin 12 measurement	KCNC3 RBMX	2.60e-03	53	42	2	EFO_0004753
Disease	hair morphology measurement	FRMD4A ADARB2	2.70e-03	54	42	2	EFO_0007821

Protein segments in the cluster

Peptide	Gene	Start	Entry
GRSPSPYGRRRSSSP	CDK12	321	Q9NYV4
SSTFYNPPSGRSRSL	CASS4	276	Q9NQ75
SSVGDASRPPYRGRS	BCR	221	P11274
YSRPGSESGRSTPSL	ABLIM2	386	Q6H8Q1
GGSSPYSRRLPRSPS	CDK13	346	Q14004
FGSKTRPRYSSPSLG	CNTN5	46	O94779
RPRYSSPSLGTLSAS	CNTN5	51	O94779
RDSYSSSSRGAPRGG	RBMX	361	P38159
ARLYGRLSTRTPSPG	ADARB2	676	Q9NS39
TGGSRPGSYVLRRSP	JAK3	391	P52333
PGSSSRYSLGPSLRR	ITPR3	1836	Q14573
TTSPGTRYGRPHSGR	DSG3	601	P32926
APADSGRYRASPTRT	ELOA2	161	Q8IYF1
SPRGRRVGTYVPSTF	SLC24A1	191	O60721
PPTGRRSGSTSSLSY	MTUS1	191	Q9ULD2
RPPGASGSALTRSFY	FAM174C	61	Q9BVV8
SPPRSLRSLFGSGYS	KIF1B	1416	O60333
PRSLSFSGPRYGRSR	NHSL1	1491	Q5SYE7
FSGPRYGRSRTPPSA	NHSL1	1496	Q5SYE7
GSRSRPSSRPSSVYG	PCLO	4286	Q9Y6V0
PLRPCRRYSTSGSSG	IMMT	26	Q16891
GSPDFYTPRTRSSNG	FRMD4A	726	Q9P2Q2
DSSPRSFRYSIGPGN	CDHR3	596	Q6ZTQ4
DYGTARRTGTPSDPR	CTNND1	301	O60716
GYSRSRSGSRGRDSP	SRSF9	191	Q13242
VGRSRAPPAASSSRY	NHS	1601	Q6T4R5
RPASPCGKRRYSSSG	NFATC4	261	Q14934
RRARPPDSSGSGESY	RNF43	436	Q68DV7
SSSGPRSFYPRQGAT	SIPA1L1	1466	O43166
SYPRPEGRTGASASF	SHROOM3	721	Q8TF72
GGSPRSSARRYSGRA	SP8	316	Q8IXZ3
AGRYPGARTASGTRP	TNFRSF10D	16	Q9UBN6
GSYPARGPRFALTLT	SPHK2	56	Q9NRA0
SRSRLSYAGGRPPSY	SRCIN1	326	Q9C0H9
SSRSGSPSYRPAMGF	IGSF9B	1261	Q9UPX0
YRRPRFLRGSSSSPG	PPM1M	31	Q96MI6
SSLSRYFRRGAPSSP	NUP188	1696	Q5SRE5
YFRRGAPSSPATGVL	NUP188	1701	Q5SRE5
GALYGRRPRSTFPNS	SPATA7	196	Q9P0W8
TYSLSSFFRGRTRPG	VIPAS39	106	Q9H9C1
GTRTYNPPTDFSGLR	ZFYVE1	361	Q9HBF4
SSRPGGYRLFSSSRP	PPIP5K1	996	Q6PFW1
PSSRARGPASSGRKY	ZFTA	66	C9JLR9
RSPSGLRPRGYTISD	TSC2	1451	P49815
SPITPGSRGRYSRDR	KCNC3	691	Q14003