Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	group II metabotropic glutamate receptor activity	GRM2 GRM3	3.06e-05	2	111	2	GO:0001641
GeneOntologyMolecularFunction	calcium channel regulator activity	PDE4B GRM2 GRM3 GEM	2.31e-04	54	111	4	GO:0005246
GeneOntologyCellularComponent	postsynaptic specialization	SEMA4F DLGAP2 PDE4B PSD INPP4A PHB2 DCC GRM3 CHRND PRR12 RBMX DAGLA	1.51e-05	503	111	12	GO:0099572
GeneOntologyCellularComponent	postsynapse	SEMA4F DLGAP2 PDE4B DSTN PSD HAP1 INPP4A PHB2 DCC GRM2 GRM3 CHRND PRR12 CYFIP1 RBMX KCNN2 DAGLA	2.58e-05	1018	111	17	GO:0098794
GeneOntologyCellularComponent	postsynaptic density	SEMA4F DLGAP2 PDE4B PSD INPP4A PHB2 DCC GRM3 PRR12 RBMX DAGLA	2.85e-05	451	111	11	GO:0014069
GeneOntologyCellularComponent	dendritic spine	DLGAP2 PDE4B PSD HAP1 GRM3 CYFIP1 KCNN2 DAGLA	4.55e-05	242	111	8	GO:0043197
GeneOntologyCellularComponent	asymmetric synapse	SEMA4F DLGAP2 PDE4B PSD INPP4A PHB2 DCC GRM3 PRR12 RBMX DAGLA	4.73e-05	477	111	11	GO:0032279
GeneOntologyCellularComponent	dendrite	PCSK5 SEMA4F DLGAP2 PDE4B PSD HAP1 RET GRM2 GRM3 CYFIP1 TNN KCNN2 NCF1C NCF1B DAGLA	4.82e-05	858	111	15	GO:0030425
GeneOntologyCellularComponent	dendritic tree	PCSK5 SEMA4F DLGAP2 PDE4B PSD HAP1 RET GRM2 GRM3 CYFIP1 TNN KCNN2 NCF1C NCF1B DAGLA	4.95e-05	860	111	15	GO:0097447
GeneOntologyCellularComponent	neuron spine	DLGAP2 PDE4B PSD HAP1 GRM3 CYFIP1 KCNN2 DAGLA	5.26e-05	247	111	8	GO:0044309
GeneOntologyCellularComponent	neuron to neuron synapse	SEMA4F DLGAP2 PDE4B PSD INPP4A PHB2 DCC GRM3 PRR12 RBMX DAGLA	1.07e-04	523	111	11	GO:0098984
GeneOntologyCellularComponent	supraspliceosomal complex	RBMXL1 RBMX	1.66e-04	4	111	2	GO:0044530
GeneOntologyCellularComponent	midbody	PDCD6IP TRIOBP GEM SH3GLB1 ANLN SVIL KIF13A	1.85e-04	222	111	7	GO:0030496
GeneOntologyCellularComponent	centrosome	PDE4B PDCD6IP TAPT1 HAP1 DIS3L RBBP6 TRIOBP STOX1 MKS1 USP2 CEP135 PRKAR1A KIF13A	2.25e-04	770	111	13	GO:0005813
GeneOntologyCellularComponent	somatodendritic compartment	PCSK5 SEMA4F DLGAP2 PDE4B PSD HAP1 RET GRM2 GRM3 CYFIP1 SH3GLB1 TNN KCNN2 NCF1C NCF1B DAGLA SORL1	2.55e-04	1228	111	17	GO:0036477
GeneOntologyCellularComponent	microtubule organizing center	PDE4B PDCD6IP TAPT1 HAP1 DIS3L RBBP6 TRIOBP STOX1 MKS1 USP2 WDR11 CEP135 PRKAR1A KIF13A	3.64e-04	919	111	14	GO:0005815
GeneOntologyCellularComponent	trans-Golgi network	PCSK5 OSBP WDR11 ATXN2 BACE2 KIF13A SORL1	1.25e-03	306	111	7	GO:0005802
Domain	PH	PSD TBC1D2B TRIOBP OSBP AFAP1L2 ANLN BTK ARHGAP21	5.20e-05	229	107	8	PF00169
Domain	Gprotein_alpha_Q	GNA14 GNA11	1.94e-04	4	107	2	IPR000654
Domain	PH	PSD TBC1D2B TRIOBP OSBP AFAP1L2 ANLN BTK ARHGAP21	1.99e-04	278	107	8	SM00233
Domain	PH_DOMAIN	PSD TBC1D2B TRIOBP OSBP AFAP1L2 ANLN BTK ARHGAP21	2.04e-04	279	107	8	PS50003
Domain	PH_domain	PSD TBC1D2B TRIOBP OSBP AFAP1L2 ANLN BTK ARHGAP21	2.09e-04	280	107	8	IPR001849
Domain	RRM_1	RBMXL1 RBMX CNOT4	2.98e-04	23	107	3	SM00361
Domain	RRM_dom_euk	RBMXL1 RBMX CNOT4	2.98e-04	23	107	3	IPR003954
Domain	GPCR_3_mtglu_rcpt	GRM2 GRM3	8.90e-04	8	107	2	IPR000162
Domain	RBM1CTR	RBMXL1 RBMX	8.90e-04	8	107	2	PF08081
Domain	RBM1CTR	RBMXL1 RBMX	8.90e-04	8	107	2	IPR012604
Domain	-	PSD TBC1D2B TRIOBP OSBP AFAP1L2 ANLN BTK ARHGAP21	1.85e-03	391	107	8	2.30.29.30
Domain	EGF	PCSK5 ADAM9 CUBN VWDE TNN SORL1	2.34e-03	235	107	6	SM00181
Domain	fn3	MYOM1 DCC DSCAML1 TNN SORL1	2.41e-03	162	107	5	PF00041
Domain	NCD3G	GRM2 GRM3	2.43e-03	13	107	2	PF07562
Domain	GPCR_3_9-Cys_dom	GRM2 GRM3	2.43e-03	13	107	2	IPR011500
Domain	GPCR_3_CS	GRM2 GRM3	2.83e-03	14	107	2	IPR017979
Domain	EGF-like_dom	PCSK5 ADAM9 CUBN VWDE TNN SORL1	3.11e-03	249	107	6	IPR000742
Domain	PH_dom-like	PSD TBC1D2B TRIOBP OSBP AFAP1L2 ANLN BTK ARHGAP21	3.13e-03	426	107	8	IPR011993
Domain	GproteinA_insert	GNA14 GNA11	3.70e-03	16	107	2	IPR011025
Domain	-	GNA14 GNA11	3.70e-03	16	107	2	1.10.400.10
Domain	G-alpha	GNA14 GNA11	3.70e-03	16	107	2	PF00503
Domain	G_alpha	GNA14 GNA11	3.70e-03	16	107	2	SM00275
Domain	Gprotein_alpha_su	GNA14 GNA11	4.18e-03	17	107	2	IPR001019
Domain	FN3	MYOM1 DCC DSCAML1 TNN SORL1	4.25e-03	185	107	5	SM00060
Domain	Fibrinogen_CS	TNN FGG	5.22e-03	19	107	2	IPR020837
Pubmed	The atypical small GTPase GEM/Kir is a negative regulator of the NADPH oxidase and NETs production through macroautophagy.	GEM NCF1C NCF1B	3.24e-07	5	112	3	34085299
Pubmed	The protein interaction landscape of the human CMGC kinase group.	PDCD6IP RBBP6 PRPF8 SETD2 AMMECR1L CIAO1 RBMX KCNN2 PRKAR1A NUP188 EBNA1BP2 MED12 SORL1	4.02e-07	695	112	13	23602568
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	CWF19L2 HIVEP1 RBBP6 PHB2 NUP214 PRPF8 TASOR2 YTHDF1 SETD2 CYFIP1 ATXN2 ANLN RBMX EBNA1BP2 TOR1AIP1	4.43e-07	954	112	15	36373674
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DLGAP2 PDE4B DSTN PDCD6IP ADAM9 PAK5 PHB2 TRIOBP GRM2 GRM3 CYFIP1 ATXN2 SVIL PRKAR1A ARHGAP21	4.99e-07	963	112	15	28671696
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	TPTE DLGAP2 PDCD6IP TMEM61 RBBP6 NUP214 RET ZKSCAN5 TASOR2 ATXN2	1.39e-06	430	112	10	35044719
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DSTN PDCD6IP DSC3 PDHA1 PHB2 NUP214 PRPF8 CYFIP1 SND1 WDR11 ANLN CIAO1 RBMX PRR14L EBNA1BP2 MED12 PARP12	1.58e-06	1353	112	17	29467282
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	RBBP6 TBC1D2B SPATA2 PRR12 RBMX SVIL ANKRD12	2.35e-06	184	112	7	32908313
Pubmed	Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.	TRIOBP PRPF8 NPLOC4 PRR12 ANLN SVIL EBNA1BP2 TOR1AIP1 ARHGAP21	2.72e-06	361	112	9	30344098
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	DSTN PDCD6IP DSC3 RBMXL1 RBBP6 PHB2 PRPF8 TASOR2 CYFIP1 SND1 WDR11 ATXN2 ANLN RBMX SVIL EBNA1BP2	2.81e-06	1257	112	16	36526897
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	PCSK5 ADAM9 NPLOC4 PRR12 WDR11 DDHD1 CRYBG3 ARHGAP21 CNOT4 PARP12 SORL1	8.51e-06	650	112	11	38777146
Pubmed	Selective silencing of individual dendritic branches by an mGlu2-activated potassium conductance in dentate gyrus granule cells.	GRM2 GRM3	1.03e-05	2	112	2	23616537
Pubmed	Group II metabotropic glutamate receptor blockade promotes stress resilience in mice.	GRM2 GRM3	1.03e-05	2	112	2	30939596
Pubmed	The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection.	GRM2 GRM3	1.03e-05	2	112	2	17670976
Pubmed	The effect of mGlu2/3 receptors on synaptic activities to different types of GABAergic interneurons in the anterior cingulate cortex.	GRM2 GRM3	1.03e-05	2	112	2	32525061
Pubmed	Expression and subcellular distribution of glutamate receptor subunits 2/3 in the developing cerebellar cortex.	GRM2 GRM3	1.03e-05	2	112	2	8838577
Pubmed	Metabotropic Glutamate Receptor 2/3 Activation Improves Motor Performance and Reduces Pathology in Heterozygous zQ175 Huntington Disease Mice.	GRM2 GRM3	1.03e-05	2	112	2	34330748
Pubmed	Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis.	GRM2 GRM3	1.03e-05	2	112	2	25434487
Pubmed	NAAG Peptidase Inhibitors Act via mGluR3: Animal Models of Memory, Alzheimer's, and Ethanol Intoxication.	GRM2 GRM3	1.03e-05	2	112	2	28285415
Pubmed	mGlu2/3 receptor in the prelimbic cortex is implicated in stress resilience and vulnerability in mice.	GRM2 GRM3	1.03e-05	2	112	2	34090896
Pubmed	Pharmacological activation of group-II metabotropic glutamate receptors corrects a schizophrenia-like phenotype induced by prenatal stress in mice.	GRM2 GRM3	1.03e-05	2	112	2	22089319
Pubmed	Regulation of cocaine-induced reinstatement by group II metabotropic glutamate receptors in the ventral tegmental area.	GRM2 GRM3	1.03e-05	2	112	2	21881873
Pubmed	Functional pseudogenes inhibit the superoxide production.	NCF1C NCF1B	1.03e-05	2	112	2	26086043
Pubmed	Fractionation of spatial memory in GRM2/3 (mGlu2/mGlu3) double knockout mice reveals a role for group II metabotropic glutamate receptors at the interface between arousal and cognition.	GRM2 GRM3	1.03e-05	2	112	2	21832989
Pubmed	The role of group II metabotropic glutamate receptors in cognition and anxiety: comparative studies in GRM2(-/-), GRM3(-/-) and GRM2/3(-/-) knockout mice.	GRM2 GRM3	1.03e-05	2	112	2	25158312
Pubmed	Altered hippocampal expression of glutamate receptors and transporters in GRM2 and GRM3 knockout mice.	GRM2 GRM3	1.03e-05	2	112	2	18720515
Pubmed	Bif-1 Interacts with Prohibitin-2 to Regulate Mitochondrial Inner Membrane during Cell Stress and Apoptosis.	PHB2 SH3GLB1	1.03e-05	2	112	2	31126972
Pubmed	MED12 exon 2 and TERT promoter mutations in primary and recurrent breast fibroepithelial lesions.	TERT MED12	1.03e-05	2	112	2	34597441
Pubmed	Metabotropic glutamate receptor 2/3 in the hippocampus of patients with mesial temporal lobe epilepsy, and of rats and mice after pilocarpine-induced status epilepticus.	GRM2 GRM3	1.03e-05	2	112	2	15246118
Pubmed	Molecular characterization of a thyroid tumor-specific transforming sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit RI alpha of cyclic AMP-dependent protein kinase A.	RET PRKAR1A	1.03e-05	2	112	2	7678053
Pubmed	Metabotropic glutamate receptor 2 and 3 gene expression in the human prefrontal cortex and mesencephalon in schizophrenia.	GRM2 GRM3	1.03e-05	2	112	2	18853337
Pubmed	Hippocampal mossy fiber long-term depression in Grm2/3 double knockout mice.	GRM2 GRM3	1.03e-05	2	112	2	21360593
Pubmed	Developmental expression of mGlu2 and mGlu3 in the mouse brain.	GRM2 GRM3	1.03e-05	2	112	2	27818290
Pubmed	TERT promoter mutations are frequent and show association with MED12 mutations in phyllodes tumors of the breast.	TERT MED12	1.03e-05	2	112	2	26355235
Pubmed	Activation of metabotropic glutamate receptor type 2/3 supports the involvement of the hippocampal mossy fiber pathway on contextual fear memory consolidation.	GRM2 GRM3	1.03e-05	2	112	2	19638469
Pubmed	Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors.	GRM2 GRM3	1.03e-05	2	112	2	21628565
Pubmed	Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice.	GRM2 GRM3	1.03e-05	2	112	2	24053122
Pubmed	Adaptive Changes in Group 2 Metabotropic Glutamate Receptors Underlie the Deficit in Recognition Memory Induced by Methamphetamine in Mice.	GRM2 GRM3	1.03e-05	2	112	2	38969501
Pubmed	Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction.	GRM2 GRM3	1.03e-05	2	112	2	25583490
Pubmed	The mGluR2/3 agonist LY379268 induced anti-reinstatement effects in rats exhibiting addiction-like behavior.	GRM2 GRM3	1.03e-05	2	112	2	23624743
Pubmed	Deletion of Metabotropic Glutamate Receptors 2 and 3 (mGlu2 & mGlu3) in Mice Disrupts Sleep and Wheel-Running Activity, and Increases the Sensitivity of the Circadian System to Light.	GRM2 GRM3	1.03e-05	2	112	2	25950516
Pubmed	Association analysis of group II metabotropic glutamate receptor genes (GRM2 and GRM3) with mood disorders and fluvoxamine response in a Japanese population.	GRM2 GRM3	1.03e-05	2	112	2	19386277
Pubmed	The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells.	GRM2 GRM3	1.03e-05	2	112	2	7965099
Pubmed	The two mRNA forms for the type I alpha regulatory subunit of cAMP-dependent protein kinase from human testis are due to the use of different polyadenylation site signals.	RET PRKAR1A	1.03e-05	2	112	2	2310396
Pubmed	Glutamate receptors and the regulation of steroidogenesis in the human adrenal gland: the metabotropic pathway.	GRM2 GRM3	1.03e-05	2	112	2	24080311
Pubmed	Identification of initiator B cells, a novel subset of activation-induced deaminase-dependent B-1-like cells that mediate initiation of contact sensitivity.	AICDA BTK	1.03e-05	2	112	2	18641308
Pubmed	Activation of Group II Metabotropic Glutamate Receptors Promotes LTP Induction at Schaffer Collateral-CA1 Pyramidal Cell Synapses by Priming NMDA Receptors.	GRM2 GRM3	1.03e-05	2	112	2	27911756
Pubmed	Reduction of group II metabotropic glutamate receptors during development of benzodiazepine dependence.	GRM2 GRM3	1.03e-05	2	112	2	23392308
Pubmed	Increased binding of cortical and hippocampal group II metabotropic glutamate receptors in isolation-reared mice.	GRM2 GRM3	1.03e-05	2	112	2	20970439
Pubmed	Behavioural and biochemical responses to methamphetamine are differentially regulated by mGlu2 and mGlu3 metabotropic glutamate receptors in male mice.	GRM2 GRM3	1.03e-05	2	112	2	34217776
Pubmed	Memantine-induced brain activation as a model for the rapid screening of potential novel antipsychotic compounds: exemplified by activity of an mGlu2/3 receptor agonist.	GRM2 GRM3	1.03e-05	2	112	2	21057775
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	PDE4B PDCD6IP SLC35A1 CUBN AMMECR1L ANLN DDHD1 RBMX GNA11 ANKRD12 NUP188 KIF13A ARHGAP21 PARP12	1.06e-05	1084	112	14	11544199
Pubmed	The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety.	PRPF8 YTHDF1 PRR12 MED12	1.14e-05	43	112	4	26487511
Pubmed	Network organization of the human autophagy system.	PDCD6IP PDHA1 TBC1D2B PHB2 SH3GLB1 SND1 WDR11 RBMX PRKAR1A	1.26e-05	437	112	9	20562859
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	DLGAP2 DSTN PDCD6IP PDHA1 INPP4A PHB2 GRM2 GRM3 CYFIP1 SND1 RBMX SVIL PRKAR1A FGG DAGLA ARHGAP21	1.43e-05	1431	112	16	37142655
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	DSTN PDCD6IP PDHA1 PAK5 PHB2 PRPF8 RNF123 SND1 ATXN2 CIAO1 RBMX CEP135 PRKAR1A NUP188 EBNA1BP2	1.63e-05	1284	112	15	17353931
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	DLGAP2 PDE4B DSTN ADAM9 PHB2 GRM3 CYFIP1	1.78e-05	251	112	7	27507650
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	RBMXL1 NUP214 YTHDF1 SND1 WDR11 ATXN2 RBMX MED12 PARP12	1.96e-05	462	112	9	31138677
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	TRIOBP PRPF8 SVIL PRKAR1A FGG BACE2 DAGLA ARHGAP21	2.82e-05	371	112	8	15747579
Pubmed	Colitis susceptibility in p47(phox-/-) mice is mediated by the microbiome.	NCF1C NCF1B	3.08e-05	3	112	2	27044504
Pubmed	NADPH oxidase in bone marrow-derived cells mediates pulmonary ischemia-reperfusion injury.	NCF1C NCF1B	3.08e-05	3	112	2	18787174
Pubmed	Deficient production of reactive oxygen species leads to severe chronic DSS-induced colitis in Ncf1/p47phox-mutant mice.	NCF1C NCF1B	3.08e-05	3	112	2	24873968
Pubmed	p47(phox) is required for afferent arteriolar contractile responses to angiotensin II and perfusion pressure in mice.	NCF1C NCF1B	3.08e-05	3	112	2	22184329
Pubmed	Natural Loss-of-Function Mutations in Qa2 and NCF1 Cause the Spread of Mannan-Induced Psoriasis.	NCF1C NCF1B	3.08e-05	3	112	2	33545139
Pubmed	Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis.	NCF1C NCF1B	3.08e-05	3	112	2	20142487
Pubmed	p47(phox) contributes to albuminuria and kidney fibrosis in mice.	NCF1C NCF1B	3.08e-05	3	112	2	25565313
Pubmed	Knockout of neutrophil cytosolic factor 1 ameliorates neuroinflammation and motor deficit after traumatic brain injury.	NCF1C NCF1B	3.08e-05	3	112	2	39357591
Pubmed	Malignant transformation of Slp65-deficient pre-B cells involves disruption of the Arf-Mdm2-p53 tumor suppressor pathway.	AICDA BTK	3.08e-05	3	112	2	20008789
Pubmed	Genetic demonstration of p47phox-dependent superoxide anion production in murine vascular smooth muscle cells.	NCF1C NCF1B	3.08e-05	3	112	2	11435342
Pubmed	Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8+ T Cell Activation via Cross-Presentation in Type 1 Diabetes.	NCF1C NCF1B	3.08e-05	3	112	2	31118934
Pubmed	Virulence comparisons of Aspergillus nidulans mutants are confounded by the inflammatory response of p47phox-/- mice.	NCF1C NCF1B	3.08e-05	3	112	2	16041040
Pubmed	RBMX is a novel hepatic transcriptional regulator of SREBP-1c gene response to high-fructose diet.	RBMXL1 RBMX	3.08e-05	3	112	2	17188681
Pubmed	SPT6 recruits SND1 to co-activate human telomerase reverse transcriptase to promote colon cancer progression.	TERT SND1	3.08e-05	3	112	2	33305480
Pubmed	Intermittent hypoxia has organ-specific effects on oxidative stress.	NCF1C NCF1B	3.08e-05	3	112	2	18703411
Pubmed	Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells.	GRM2 GRM3	3.08e-05	3	112	2	34620856
Pubmed	Mycobacteria-induced Gr-1+ subsets from distinct myeloid lineages have opposite effects on T cell expansion.	NCF1C NCF1B	3.08e-05	3	112	2	17307863
Pubmed	Ncf1 affects osteoclast formation but is not critical for postmenopausal bone loss.	NCF1C NCF1B	3.08e-05	3	112	2	27829407
Pubmed	Molecular mutations as a possible factor for determining extent of thyroid surgery.	RET TERT	3.08e-05	3	112	2	31623671
Pubmed	The presence of p47phox in liver parenchymal cells is a key mediator in the pathogenesis of alcoholic liver steatosis.	NCF1C NCF1B	3.08e-05	3	112	2	22376231
Pubmed	Leishmania amazonensis amastigotes trigger neutrophil activation but resist neutrophil microbicidal mechanisms.	NCF1C NCF1B	3.08e-05	3	112	2	23918780
Pubmed	NADPH oxidase NOX2 mediates TLR2/6-dependent release of GM-CSF from endothelial cells.	NCF1C NCF1B	3.08e-05	3	112	2	28274989
Pubmed	Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II.	NCF1C NCF1B	3.08e-05	3	112	2	12364355
Pubmed	NOX2-Deficient Neutrophils Facilitate Joint Inflammation Through Higher Pro-Inflammatory and Weakened Immune Checkpoint Activities.	NCF1C NCF1B	3.08e-05	3	112	2	34557202
Pubmed	Reactive Oxygen Species Regulate Both Priming and Established Arthritis, but with Different Mechanisms.	NCF1C NCF1B	3.08e-05	3	112	2	28467721
Pubmed	P47(phox)-deficient NADPH oxidase defect in neutrophils of diabetic mouse strains, C57BL/6J-m db/db and db/+.	NCF1C NCF1B	3.08e-05	3	112	2	10670582
Pubmed	Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes.	NCF1C NCF1B	3.08e-05	3	112	2	26528554
Pubmed	The role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis.	NCF1C NCF1B	3.08e-05	3	112	2	19052348
Pubmed	Effect of early particulate air pollution exposure on obesity in mice: role of p47phox.	NCF1C NCF1B	3.08e-05	3	112	2	20864666
Pubmed	Polymorphisms in miRNA processing genes and their role in osteosarcoma risk.	SND1 CNOT4	3.08e-05	3	112	2	25663449
Pubmed	Reactive oxygen species delay control of lymphocytic choriomeningitis virus.	NCF1C NCF1B	3.08e-05	3	112	2	23328631
Pubmed	p47phox-Dependent Oxidant Signalling through ASK1, MKK3/6 and MAPKs in Angiotensin II-Induced Cardiac Hypertrophy and Apoptosis.	NCF1C NCF1B	3.08e-05	3	112	2	34572995
Pubmed	Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice.	NCF1C NCF1B	3.08e-05	3	112	2	17114280
Pubmed	RBMY evolved on the Y chromosome from a ubiquitously transcribed X-Y identical gene.	RBMXL1 RBMX	3.08e-05	3	112	2	10391207
Pubmed	B-cell epitope spreading and inflammation in a mouse model of arthritis is associated with a deficiency in reactive oxygen species production.	NCF1C NCF1B	3.08e-05	3	112	2	25989352
Pubmed	Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase.	NCF1C NCF1B	3.08e-05	3	112	2	17404617
Pubmed	Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling/dysfunction and survival after myocardial infarction.	NCF1C NCF1B	3.08e-05	3	112	2	17332431
Pubmed	Lpp of Escherichia coli K1 inhibits host ROS production to counteract neutrophil-mediated elimination.	NCF1C NCF1B	3.08e-05	3	112	2	36592568
Pubmed	Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination.	AICDA PRKAR1A	3.08e-05	3	112	2	19234474
Pubmed	Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression.	NCF1C NCF1B	3.08e-05	3	112	2	30504842
Pubmed	Direct interaction of HIV gp120 with neuronal CXCR4 and CCR5 receptors induces cofilin-actin rod pathology via a cellular prion protein- and NOX-dependent mechanism.	NCF1C NCF1B	3.08e-05	3	112	2	33705493
Pubmed	Inhibition of NADPH oxidase by apocynin attenuates progression of atherosclerosis.	NCF1C NCF1B	3.08e-05	3	112	2	23965970
Cytoband	4q28	SETD7 FGG	2.10e-04	9	112	2	4q28
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PSD TRIOBP OSBP AFAP1L2 ANLN BTK ARHGAP21	1.34e-05	206	69	7	682
GeneFamily	Fibronectin type III domain containing	MYOM1 DCC DSCAML1 TNN SORL1	3.63e-04	160	69	5	555
GeneFamily	Glutamate metabotropic receptors\|Protein phosphatase 1 regulatory subunits	GRM2 GRM3	3.96e-04	8	69	2	281
ToppCell	droplet-Pancreas-Endocrine\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HAP1 GCG PRKAR1A NKTR SARAF ANKRD12 BACE2	5.73e-07	192	112	7	0dfd1e9896c34aee0f842f8de5d0e3af62a15f68
ToppCell	facs\|World / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE4B INPP4A GCG PRR14L MAP4K2 SORL1	4.73e-06	171	112	6	c9990bc041a632b2f7bbebbfe737772c423d7027
ToppCell	Cerebellum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Acta2Rgs5.Acta2_(Mural.Acta2Rgs5.Acta2)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	DSTN MYOM1 GEM PHEX GNA14	9.90e-06	113	112	5	7c5317bda7f13649af4837ca717dfdad74152f8f
ToppCell	Cerebellum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Acta2Rgs5.Acta2_(Mural.Acta2Rgs5.Acta2)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	DSTN MYOM1 GEM PHEX GNA14	9.90e-06	113	112	5	3c745f4d975475860e793f304a846b032515b334
ToppCell	Cerebellum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1\|Cerebellum / BrainAtlas - Mouse McCarroll V32	DSTN MYOM1 GEM PHEX GNA14	9.90e-06	113	112	5	d67022ae14fae91f9f21ebe8c6ab6d8d6d725bc4
Disease	HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 1	RET BACE2 MED12	9.20e-07	6	107	3	C3888239
Disease	Addicted to cocaine	GRM2 GRM3	3.90e-05	3	107	2	C0858355
Disease	chronic granulomatous disease (implicated_via_orthology)	NCF1C NCF1B	1.29e-04	5	107	2	DOID:3265 (implicated_via_orthology)
Disease	Malignant Cystosarcoma Phyllodes	SETD2 MED12	1.29e-04	5	107	2	C0600066
Disease	Phyllodes Tumor	SETD2 MED12	1.29e-04	5	107	2	C0010701
Disease	Malignant neoplasm of thyroid	RET PRKAR1A	1.29e-04	5	107	2	C0007115
Disease	interleukin-23 measurement	ATXN2 TSBP1	1.94e-04	6	107	2	EFO_0020501
Disease	melanoma	RET CUBN DCC GRM3 TERT GNA11	2.95e-04	248	107	6	C0025202
Disease	Thyroid Neoplasm	RET TERT PRKAR1A	3.29e-04	37	107	3	C0040136
Disease	Lymphoid leukemia	AICDA TERT	3.60e-04	8	107	2	C0023448
Disease	thioredoxin domain-containing protein 12 measurement	GRM2 RNF123 IP6K2	3.85e-04	39	107	3	EFO_0008298
Disease	ciliopathy (implicated_via_orthology)	MKS1 WDR11 MAP4K2	4.15e-04	40	107	3	DOID:0060340 (implicated_via_orthology)
Disease	cervical cancer	DLGAP2 PDE4B STOX1	4.15e-04	40	107	3	MONDO_0002974
Disease	Leukemia, Myelocytic, Acute	PDE4B NUP214 TERT SETD2 SVIL	4.29e-04	173	107	5	C0023467
Disease	idiopathic pulmonary fibrosis (is_implicated_in)	TERT SETD2	4.61e-04	9	107	2	DOID:0050156 (is_implicated_in)
Disease	Malignant neoplasm of breast	TPTE DSC3 NUP214 CUBN TERT FSCB CHRND SETD2 BTK TOR1AIP1 MED12 SORL1	5.25e-04	1074	107	12	C0006142
Disease	Thyroid carcinoma	RET TERT PRKAR1A	5.51e-04	44	107	3	C0549473
Disease	fibrinogen measurement	PRR12 WDR11 ATXN2 FGG	6.79e-04	109	107	4	EFO_0004623
Disease	gastrointestinal stromal tumor (is_implicated_in)	TERT SETD2	7.01e-04	11	107	2	DOID:9253 (is_implicated_in)
Disease	rheumatoid arthritis (implicated_via_orthology)	NCF1C NCF1B	8.40e-04	12	107	2	DOID:7148 (implicated_via_orthology)
Disease	Acute Myeloid Leukemia, M1	PDE4B NUP214 TERT SVIL	1.13e-03	125	107	4	C0026998
Disease	Acute Myeloid Leukemia (AML-M2)	PDE4B NUP214 TERT SVIL	1.13e-03	125	107	4	C1879321
Disease	age-related hearing impairment	TRIOBP ZFP69 NPLOC4 GNA14 TSBP1 PRR14L	1.19e-03	324	107	6	EFO_0005782
Disease	Carcinoma of Endocrine Gland	RET PRKAR1A	1.33e-03	15	107	2	C1704374
Disease	Schizophrenia	DLGAP2 PDE4B PSD DCC GRM2 GRM3 CYFIP1 WDR11 ATXN2 MED12	1.41e-03	883	107	10	C0036341
Disease	Acute myeloid leukemia	NUP214 TERT	1.71e-03	17	107	2	cv:C0023467
Disease	LEUKEMIA, ACUTE MYELOID	NUP214 TERT	1.71e-03	17	107	2	601626
Disease	platelet component distribution width	MYT1 CUBN SETD2 CYFIP1 AFAP1L2 ATXN2 TNN DDHD1 SVIL	1.73e-03	755	107	9	EFO_0007984
Disease	Adrenocortical carcinoma	TERT MED12	1.92e-03	18	107	2	C0206686
Disease	Alzheimer disease, educational attainment	PSD DCC BACE2 IP6K2 SORL1	2.10e-03	247	107	5	EFO_0011015, MONDO_0004975
Disease	urinary microalbumin measurement	CUBN KCNN2	2.37e-03	20	107	2	EFO_0010967
Disease	worry measurement	HIVEP1 GRM3 SND1 KCNN2	2.43e-03	154	107	4	EFO_0009589
Disease	juvenile idiopathic arthritis	ATXN2 TSBP1 KCNN2	2.49e-03	74	107	3	EFO_0002609
Disease	Amphetamine-Related Disorders	PDE4B CUBN GRM2	2.59e-03	75	107	3	C0236733
Disease	Amphetamine Abuse	PDE4B CUBN GRM2	2.59e-03	75	107	3	C0236807
Disease	Amphetamine Addiction	PDE4B CUBN GRM2	2.59e-03	75	107	3	C0236804
Disease	Autoimmune Hepatitis	ATXN2 TSBP1	2.62e-03	21	107	2	EFO_0005676
Disease	level of Phosphatidylcholine (18:1_20:4) in blood serum	DCC DAGLA	2.62e-03	21	107	2	OBA_2045104
Disease	fetal hemoglobin measurement	PHEX KCNN2	2.62e-03	21	107	2	EFO_0004576
Disease	disease of metabolism (implicated_via_orthology)	PDHA1 YTHDF1	2.62e-03	21	107	2	DOID:0014667 (implicated_via_orthology)
Disease	otitis media (implicated_via_orthology)	NAGLU PHEX	2.87e-03	22	107	2	DOID:10754 (implicated_via_orthology)
Disease	Lung diseases	PCSK5 RET TERT	2.90e-03	78	107	3	C0024115
Disease	Epilepsy, Benign Psychomotor, Childhood	GRM2 GRM3	3.14e-03	23	107	2	C0393672
Disease	Epilepsy, Lateral Temporal	GRM2 GRM3	3.14e-03	23	107	2	C0393682
Disease	Uncinate Epilepsy	GRM2 GRM3	3.14e-03	23	107	2	C0014558
Disease	Epilepsy, Temporal Lobe	GRM2 GRM3	3.14e-03	23	107	2	C0014556
Disease	partial thromboplastin time	TSBP1 FGG	3.41e-03	24	107	2	EFO_0004310

Protein segments in the cluster

Peptide	Gene	Start	Entry
RRSSSLGYISKAEEY	CHRND	376	Q07001
IDTYFDTERSSTYRS	BACE2	126	Q9Y5Z0
RSEKVTISYAEYIAS	AMMECR1L	276	Q6DCA0
SLTAIYDKRRETDYS	CRYBG3	1966	Q68DQ2
GLSRYVLDDEYTSSV	BTK	541	Q06187
ASTSAKLSDKSRYDY	GRM2	166	Q14416
YASTSAKLSDKSRYD	GRM3	171	Q14832
YVVKRRDSATSFSLD	AICDA	31	Q9GZX7
LRLYTKSSSSDEEYI	AFAP1L2	41	Q8N4X5
FSYREDYRTQVDTST	DLGAP2	826	Q9P1A6
ERLISSYRTYSEKEG	ANKRD12	91	Q6UB98
RYALYDASFETKESR	DSTN	81	P60981
EYYVEESRSARLRKS	CAVIN4	176	Q5BKX8
YEEARSAYLSKELAS	NAGLU	576	P54802
TKDSYSSRDYPSSRD	RBMX	216	P38159
VYSITDRASFEKASE	GEM	156	P55040
SYYAERLSRAAKDRS	INPP4A	426	Q96PE3
TYGDVYKARDTVTSE	MAP4K2	26	Q12851
DTTADYTTEKYREKS	PAK5	136	Q9P286
ERATRYNYTSEEKFA	CYFIP1	436	Q7L576
SKQRYYSIERLESSS	DCC	776	P43146
TVASTYKSRYEEALR	MAGEB17	296	A8MXT2
AVLERQESYRFYSSS	IP6K2	316	Q9UHH9
YSAKAYESIRVSSEL	FSCB	41	Q5H9T9
SYDKHVTYNAERSRS	KCNN2	546	Q9H2S1
YSIDAYRSQRFKETE	ANLN	671	Q9NQW6
SYAKRDAFTDSAISA	ATXN2	346	Q99700
TRESYDDVSSFRAKT	EBNA1BP2	261	Q99848
RTKRDYDFSRAQSTY	PCSK5	111	Q92824
AELIKTVASRYDEYV	PDCD6IP	281	Q8WUM4
RESFLYRSDSDYDLS	PDE4B	131	Q07343
DLVKYGNSSRDRYAT	CWF19L2	306	Q2TBE0
RYSRNKDTYFLSSEE	NPLOC4	326	Q8TAT6
TADSATFIRIEKAYR	DNAJC28	86	Q9NX36
RYYEDLDEVSSTSSV	NUP214	976	P35658
ASLNSREYRAKSYEI	KRIT1	21	O00522
ETASLDVYAKYVLRS	MED12	1271	Q93074
GTFTSDYSKYLDSRR	GCG	56	P01275
YEDADLRARTKIVYS	DPY19L2	661	Q6NUT2
EDDVYLRHSSSLTYR	HMHB1	26	O97980
YSYFSRDVARKVTGE	OSBP	616	P22059
ELSFSREYTAAVEAK	PHB2	186	Q99623
TYRAIANYEKTSGSE	NCF1B	161	A6NI72
TYRAIADYEKTSGSE	NCF1C	136	A8MVU1
RDKKTDYDTREYSSS	RBBP6	1471	Q7Z6E9
DYDTREYSSSKRRDE	RBBP6	1476	Q7Z6E9
TTVSSSDVEKAYLAY	PARP12	401	Q9H0J9
ELRYSLSSYTSDRER	PCDHAC2	291	Q9Y5I4
TDYDALKRQISTERY	CEP135	1091	Q66GS9
YLRFKSDSVTSDRGY	CUBN	3486	O60494
KYEASILTHDSSIRY	FGG	121	P02679
TVSHYLDREVVDKYS	DSC3	306	Q14574
TESASSTYEELARAY	DSCAML1	1801	Q8TD84
SYIDIEARTRATTYY	DIS3L	516	Q8TF46
SAKYYLTDVDRIATL	GNA11	156	P29992
DTSSLRYDFRYSEDR	HAP1	516	P54257
SYFRKKRSQTYESDG	ADAM9	726	Q13443
RTKDSQSDAYSEIAY	DAGLA	206	Q9Y4D2
SAEVYTEEDAASYVR	PRKAR1A	101	P10644
EVYLYSDATTSKIAR	DDHD1	356	Q8NEL9
KRSAEKTDSSYFYRG	PRR14L	371	Q5THK1
STYSTERESRAAVLY	OR1N2	281	Q8NGR9
YEETLSTLRYADRAK	KIF13A	336	Q9H1H9
DSAKYYLTDIDRIAT	GNA14	151	O95837
VYTIALRYTRTSDKE	SLC35A1	26	P78382
LRYTRTSDKELYFST	SLC35A1	31	P78382
RKSIYRYDLASGATE	SORL1	766	Q92673
TKDSYSSRDYPSSRD	RBMXL1	216	Q96E39
EFEKSRYSTYAALLR	PSD	946	A5PKW4
FTETSRAFDSYERIK	SEMA4F	251	O95754
PEADSEYLSRYTKSR	SVIL	126	O95425
DVKALTLHYDRYTTS	SARAF	41	Q96BY9
RKYSESRSSLDYSSD	NKTR	796	P30414
YESERVYVAESLISS	SETD7	211	Q8WTS6
RVLYDYDAANSTELS	SH3GLB1	311	Q9Y371
RSSYYKSLLSAEEAA	SND1	636	Q7KZF4
SYERSAKASLVYGSS	PRR12	21	Q9ULL5
STYDSSDTNAKRFRV	ABCC12	81	Q96J65
DSSLKYYRDSTAEEA	TRIOBP	1816	Q9H2D6
AAKRTSKEYLRSAYT	CFAP20DC	436	Q6ZVT6
SKEYLRSAYTEAGAT	CFAP20DC	441	Q6ZVT6
ASASYDDTVKLYREE	CIAO1	166	O76071
SASAYVTYIRSEDAL	CNOT4	156	O95628
IERYARAKFLDYTTD	PRPF8	1676	Q6P2Q9
RDLYYLTVESSEKES	TMEM61	106	Q8N0U2
YYTAVTDFSRDGDRV	VWDE	376	Q8N2E2
TAKESLYYFGERRTD	TPTE	361	P56180
RVTKPSRSVDAYDSY	SPATA2	246	Q9UM82
RSDSAKEEVRESAYY	TOR1AIP1	91	Q5JTV8
KNRRIFTYTDSDRYT	MKS1	121	Q9NXB0
TSVERAAASTDYYKR	PDHA1	231	P08559
ATIDKYVVRYTSADD	TNN	556	Q9UQP3
DRYVVRYTSAKDGET	TNN	736	Q9UQP3
DRKRFSLQSYADYIS	RNF123	1206	Q5XPI4
DYYSARKASFEAEVI	STOX1	856	Q6ZVD7
YLQEDYRGTRDSVKT	NUP188	96	Q5SRE5
VREDYLDNSTEAKSY	PHEX	231	P78562
NDTYSEVKADYSIGR	PKD2L2	491	Q9NZM6
PSRSKTDRDDKYFSY	SETD2	366	Q9BYW2
SEEEYKKTYSRRTSS	SETD2	461	Q9BYW2
SRDVYEEDSYVKRSQ	RET	896	P07949
ITADVYSEYRASLAF	TAPT1	366	Q6NXT6
EDSYTLRGSYTRKKD	TASOR2	1846	Q5VWN6
DTEKLITAIYADYAR	WDR11	1171	Q9BZH6
STLKRYTESARYTDA	USP2	6	O75604
DTSYDNRERSKRDYT	TSBP1	66	Q5SRN2
TERSKSYDEGLDDYR	ARHGAP21	876	Q5T5U3
TVRSSQYDKYFTSSR	TBC1D2B	371	Q9UPU7
ESDEKQRFSYERSGY	HIVEP1	2161	P15822
DTRTLEVQSDYSSYA	TERT	936	O14746
EVQSDYSSYARTSIR	TERT	941	O14746
YAKLLSERAAVDASY	TEX12	71	Q9BXU0
SLYRDDRKENYGSIT	ZKSCAN5	241	Q9Y2L8
SYSEDDIHRSIKYSI	YTHDF1	396	Q9BYJ9
DDIIYSTLRKVSTYD	ZFP69	181	Q49AA0
DIAYTYDRSKTSARI	NAALADL1	526	Q9UQQ1
EVSRKAASAYDYGSS	MYOM1	81	P52179
DTVRKSYYSKDPSRA	MYT1	421	Q01538