Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	carbohydrate binding	CILP2 CLEC4F PRG3 GALNT3 PRG2 CLEC4G MGAM2	1.70e-05	310	53	7	GO:0030246
GeneOntologyMolecularFunction	extracellular matrix structural constituent conferring compression resistance	PRG3 PRG2	1.69e-03	23	53	2	GO:0030021
Domain	EMBP_CTLD	PRG3 PRG2	8.51e-06	2	55	2	IPR033816
Domain	Eosinophil_major_basic	PRG3 PRG2	8.51e-06	2	55	2	IPR002352
Domain	Pecanex_C	PCNX3 PCNX1	5.09e-05	4	55	2	PF05041
Domain	Pecanex	PCNX3 PCNX1	5.09e-05	4	55	2	IPR007735
Domain	C_TYPE_LECTIN_1	CLEC4F PRG3 PRG2 CLEC4G	9.02e-05	80	55	4	PS00615
Domain	Lectin_C	CLEC4F PRG3 PRG2 CLEC4G	1.09e-04	84	55	4	PF00059
Domain	CLECT	CLEC4F PRG3 PRG2 CLEC4G	1.09e-04	84	55	4	SM00034
Domain	C_TYPE_LECTIN_2	CLEC4F PRG3 PRG2 CLEC4G	1.14e-04	85	55	4	PS50041
Domain	C-type_lectin-like	CLEC4F PRG3 PRG2 CLEC4G	1.19e-04	86	55	4	IPR001304
Domain	WxxW_domain	CILP2 MUC2	1.27e-04	6	55	2	IPR025155
Domain	Mucin2_WxxW	CILP2 MUC2	1.27e-04	6	55	2	PF13330
Domain	VWFC_1	ZAN CHRD MUC2	1.61e-04	36	55	3	PS01208
Domain	VWC	ZAN CHRD MUC2	1.89e-04	38	55	3	SM00214
Domain	VWFC_2	ZAN CHRD MUC2	1.89e-04	38	55	3	PS50184
Domain	-	CLEC4F PRG3 PRG2 CLEC4G	1.90e-04	97	55	4	3.10.100.10
Domain	C-type_lectin-like/link	CLEC4F PRG3 PRG2 CLEC4G	2.06e-04	99	55	4	IPR016186
Domain	VWF_dom	ZAN CHRD MUC2	2.56e-04	42	55	3	IPR001007
Domain	C-type_lectin_CS	PRG3 PRG2 CLEC4G	2.74e-04	43	55	3	IPR018378
Domain	CTDL_fold	CLEC4F PRG3 PRG2 CLEC4G	2.77e-04	107	55	4	IPR016187
Domain	TIL	ZAN MUC2	5.51e-04	12	55	2	PF01826
Domain	His_Phos_1	UBASH3A PGAM1	5.51e-04	12	55	2	PF00300
Domain	His_Pase_superF_clade-1	UBASH3A PGAM1	5.51e-04	12	55	2	IPR013078
Domain	C8	ZAN MUC2	5.51e-04	12	55	2	PF08742
Domain	Unchr_dom_Cys-rich	ZAN MUC2	6.50e-04	13	55	2	IPR014853
Domain	C8	ZAN MUC2	6.50e-04	13	55	2	SM00832
Domain	TIL_dom	ZAN MUC2	7.57e-04	14	55	2	IPR002919
Domain	VWD	ZAN MUC2	9.95e-04	16	55	2	SM00216
Domain	VWF_type-D	ZAN MUC2	9.95e-04	16	55	2	IPR001846
Domain	VWFD	ZAN MUC2	9.95e-04	16	55	2	PS51233
Domain	VWD	ZAN MUC2	9.95e-04	16	55	2	PF00094
Domain	VWC_out	ZAN MUC2	1.41e-03	19	55	2	SM00215
Domain	His_PPase_superfam	UBASH3A PGAM1	1.56e-03	20	55	2	IPR029033
Domain	-	UBASH3A PGAM1	1.56e-03	20	55	2	3.40.50.1240
Domain	GPS	PKD1L1 ADGRF3	5.03e-03	36	55	2	PS50221
Domain	GPS	PKD1L1 ADGRF3	5.31e-03	37	55	2	IPR000203
Pubmed	GALNT3 Maintains the Epithelial State in Trophoblast Stem Cells.	GALNT3 MAP3K4	2.55e-06	2	56	2	30917321
Pubmed	Human eosinophil major basic protein 2: location of disulfide bonds and free sulfhydryl groups.	PRG3 PRG2	2.55e-06	2	56	2	17136616
Pubmed	Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH.	CCR2 CLEC4F	2.55e-06	2	56	2	33440159
Pubmed	Comparative structure, proximal promoter elements, and chromosome location of the human eosinophil major basic protein genes.	PRG3 PRG2	2.55e-06	2	56	2	11170744
Pubmed	Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver.	CCR2 CLEC4F	7.63e-06	3	56	2	32888418
Pubmed	Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches.	CCR2 CLEC4F	7.63e-06	3	56	2	35021063
Pubmed	HIV-Tat protein transduction domain specifically attenuates growth of polyamine deprived tumor cells.	PRG3 PRG2	1.52e-05	4	56	2	17308074
Pubmed	Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche.	CCR2 CLEC4F	1.52e-05	4	56	2	31561945
Pubmed	KLF4 deletion alters gastric cell lineage and induces MUC2 expression.	LGR5 MUC2	1.52e-05	4	56	2	27277677
Pubmed	In situ expansion and reprogramming of Kupffer cells elicit potent tumoricidal immunity against liver metastasis.	CCR2 CLEC4F	2.54e-05	5	56	2	36821387
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	PRG3 PRSS53 PKD1L1 CLEC4G SYPL2 CHRD FAM124A ADGRF3 LNX1	2.59e-05	985	56	9	12975309
Pubmed	Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins.	CES1P1 CES5A	3.80e-05	6	56	2	20931200
Pubmed	Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q.	GRM4 DNAJC3	3.80e-05	6	56	2	8824806
Pubmed	Identification of a new murine eosinophil major basic protein (mMBP) gene: cloning and characterization of mMBP-2.	PRG3 PRG2	3.80e-05	6	56	2	10770291
Pubmed	Interferon b drives intestinal regeneration after radiation.	CCR2 LGR5	1.14e-04	10	56	2	34613772
Pubmed	Tracing colonic embryonic transcriptional profiles and their reactivation upon intestinal damage.	LGR5 MUC2	1.39e-04	11	56	2	34348153
Pubmed	Kupffer-cell-derived IL-6 is repurposed for hepatocyte dedifferentiation via activating progenitor genes from injury-specific enhancers.	CCR2 CLEC4F	2.29e-04	14	56	2	36787740
Pubmed	General transcription factor TAF4 antagonizes epigenetic silencing by Polycomb to maintain intestine stem cell functions.	LGR5 MUC2	2.29e-04	14	56	2	36639541
Pubmed	The G protein-coupled receptor repertoires of human and mouse.	RXFP4 ADGRF3 GRM4	2.87e-04	79	56	3	12679517
Pubmed	Mouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate.	LGR5 MUC2	3.01e-04	16	56	2	20691176
Pubmed	Tracing the origin of adult intestinal stem cells.	LGR5 MUC2	3.01e-04	16	56	2	31092921
Pubmed	Mesenchymal-epithelial interaction regulates gastrointestinal tract development in mouse embryos.	LGR5 MUC2	3.83e-04	18	56	2	35830795
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	FAT4 RUNDC3A CLEC4F MEGF8 CHRD LNX1	4.31e-04	608	56	6	16713569
Pubmed	Use of (alternative) coreceptors for HIV entry.	CCR2 CLEC4G	5.24e-04	21	56	2	22842622
Pubmed	Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice.	LGR5 MUC2	6.30e-04	23	56	2	24680895
Pubmed	E-cadherin is required for intestinal morphogenesis in the mouse.	LGR5 MUC2	6.87e-04	24	56	2	22766025
Pubmed	Induction of Gastric Cancer by Successive Oncogenic Activation in the Corpus.	LGR5 MUC2	7.46e-04	25	56	2	34391772
Pubmed	Mouse oocytes develop in cysts with the help of nurse cells.	TLE6 LGR5	8.07e-04	26	56	2	35623357
Pubmed	A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting.	CCR2 LGR5	1.01e-03	29	56	2	33567267
Pubmed	A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins.	GALNT3 CLEC4G	1.30e-03	33	56	2	23118208
Pubmed	Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity.	LGR5 MUC2	1.55e-03	36	56	2	27736991
Cytoband	11q12	PRG3 PRG2	3.02e-04	21	56	2	11q12
Cytoband	16q12.2	CES1P1 CES5A	4.66e-04	26	56	2	16q12.2
Cytoband	Ensembl 112 genes in cytogenetic band chr3p22	VILL CYP8B1 PLCD1	1.50e-03	184	56	3	chr3p22
Cytoband	1q22	RXFP4 MSTO1	2.23e-03	57	56	2	1q22
Cytoband	Ensembl 112 genes in cytogenetic band chr1q22	RXFP4 MSTO1	3.44e-03	71	56	2	chr1q22
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	PRG3 PRG2	3.35e-03	41	38	2	1298
GeneFamily	C-type lectin domain family	CLEC4F CLEC4G	4.38e-03	47	38	2	494
Disease	Adenocarcinoma	FAT4 PGAM1 MUC2	1.27e-03	116	54	3	C0001418
Disease	Carcinoma, Granular Cell	FAT4 PGAM1 MUC2	1.27e-03	116	54	3	C0205644
Disease	Adenocarcinoma, Tubular	FAT4 PGAM1 MUC2	1.27e-03	116	54	3	C0205645
Disease	Adenocarcinoma, Oxyphilic	FAT4 PGAM1 MUC2	1.27e-03	116	54	3	C0205642
Disease	Carcinoma, Cribriform	FAT4 PGAM1 MUC2	1.27e-03	116	54	3	C0205643
Disease	Adenocarcinoma, Basal Cell	FAT4 PGAM1 MUC2	1.27e-03	116	54	3	C0205641
Disease	pappalysin‐1 measurement	PRG3 PRG2	1.29e-03	29	54	2	EFO_0010618
Disease	anxiety disorder	PKD1L1 MGAM2	1.38e-03	30	54	2	EFO_0006788
Disease	eosinophil count	CILP2 RUNDC3A PRG3 CHERP CYP8B1 PRG2 PCNX1 UBASH3A MUC2	1.40e-03	1488	54	9	EFO_0004842
Disease	dentate gyrus volume measurement	PKD1L1 LNX1	2.33e-03	39	54	2	EFO_0010083
Disease	non-alcoholic fatty liver disease (biomarker_via_orthology)	CYP8B1 SIRT4	6.35e-03	65	54	2	DOID:0080208 (biomarker_via_orthology)
Disease	lobe attachment	FAT4 LIPN LNX1	6.49e-03	207	54	3	EFO_0007667

Protein segments in the cluster

Peptide	Gene	Start	Entry
VFWDHSLFQGRGGWS	ADGRF3	716	Q8IZF5
NQTGHFFWMGSDSWG	GRM4	301	Q14833
GTFNWDNLLNWGPGF	FAT4	4926	Q6V0I7
GDFRHWNEWGAFQPQ	CRYBB1	211	P53674
WQFPHFNALSWGLRE	COX10	321	Q12887
QGGGGNPFHRSWNSW	DNAJC3	471	Q13217
NPFHRSWNSWQGFNP	DNAJC3	476	Q13217
SWNSWQGFNPFSSGG	DNAJC3	481	Q13217
WGFFSTGDEHSPGNW	CES1P1	176	Q9UKY3
WNHFDFVWGLDAPQR	LIPN	371	Q5VXI9
FPWNWGYEASNGHTN	MGAM2	86	Q2M2H8
NFIWVHHPWAFGDAG	NTSR1	126	P30989
WFSNTGAPGHRASEW	FAM124A	381	Q86V42
IAPWQITWGSAFHAF	PCNX1	1461	Q96RV3
PWQITWGSAFHAFAQ	PCNX3	1251	Q9H6A9
CNWTGWLDSGKPNFH	MUC2	1786	Q02817
FAGFVGAHWWNQQDA	MSTO1	16	Q9BUK6
GFFTTWDQHAPGNWA	CES5A	181	Q6NT32
GAGWWHNVSARDPAF	MEGF8	211	Q7Z7M0
IFQEAGWNSNGSWSP	LNX1	471	Q8TBB1
TNNGFNPWWDTEFAF	PLCD1	676	P51178
DGSRWNFAYWAAHQP	PRG2	176	P13727
NFAYWAAHQPWSRGG	PRG2	181	P13727
SHWNFAYWSPGQPGN	PRG3	181	Q9Y2Y8
WANITWKHNFGPGTD	NFASC	1131	O94856
AAWNSQFEGPWNSQH	CHERP	486	Q8IWX8
HNRGNFDWSLSFGWE	GALNT3	326	Q14435
PLWAHSAANEWVFGN	CCR2	96	P41597
FAFSAWWHGLHPGQV	MBOAT4	331	Q96T53
HTGQGWFFPAQCWLS	PKD1L1	1886	Q8TDX9
HGESAWNLENRFSGW	PGAM1	11	P18669
WASQGNTGPTSFWAL	CYP8B1	281	Q9UNU6
FGSFARHGAWWENGV	LGR5	621	O75473
WGAPDWSTEAGFSRH	MAP3K4	506	Q9Y6R4
PVSWFSSDGQRGFWD	RUNDC3A	81	Q59EK9
FWAAESALDFHWPFG	RXFP4	96	Q8TDU9
WFVFKETPWHGQGQG	SYPL2	231	Q5VXT5
HAQAKGWWDGQGAFD	SCRN2	211	Q96FV2
WARNFVGWPQFSSHQ	SIRT4	106	Q9Y6E7
QNFSFWWSHDPGVRP	TEX49	81	A0A1B0GTD5
AKPDHNDPFFSWGWE	NAP1L3	381	Q99457
GFQHTQGTWVPWSQD	SPEM1	156	Q8N4L4
ASEWTSWFNVDHPGG	CILP2	56	Q8IUL8
GSWRWTDGTPFNAAQ	CLEC4F	536	Q8N1N0
SFSHWNQGEPNDAWG	CLEC4G	246	Q6UXB4
GCRFAGQWFPESQSW	CHRD	871	Q9H2X0
LFGPGFANSSWSWVA	CNNM3	66	Q8NE01
RFPFGASCWATGWDQ	PRSS53	151	Q2L4Q9
FFNNTVHSQGWFGMW	PKHD1L1	2611	Q86WI1
QGHEPPTFIGWFFTW	VILL	691	O15195
IFFNNVPTWWTVGGA	SLC35G1	331	Q2M3R5
PDGSWFAWSQGHCIV	WSB2	36	Q9NYS7
NNHWQTAPFWNLGSF	SULF1	751	Q8IWU6
NHWNSILWSFPFQQG	TERB1	691	Q8NA31
SSTWFHNHSNSGGGW	ZNF106	171	Q9H2Y7
SVKFSPFGQWWASVG	TLE6	506	Q9H808
CPGTWKTWGFHNNFL	ZNF461	76	Q8TAF7
HGANAAFNWRNWISG	UBASH3A	646	P57075
PFCDWVQTSGDGGHW	ZAN	381	Q9Y493
WGPWSAGGSRQVQFH	MYO1E	886	Q12965