Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transporter activity	NPC1 SLC12A6 CACNA1C CACNA1D ABCC3 ATP13A4 SCN11A CLCA4 SLC4A8 ATP7B IPO8 SLC35D2 SLC5A9 ATP13A5 OCA2 OTOP3 ANO10 ATP9A PKDREJ SLC7A11 SLC12A5 ITPR1 SLC5A11 ABCG4 PKD2L2 P2RX3 SLC15A1 KCNC3 SCN7A SLC28A2 OTOP1 SERINC3 CACNA1I PACC1 GJB7 SLC29A1 KCNH5 SLC35B1	4.12e-13	1289	154	38	GO:0005215
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC12A6 CACNA1C CACNA1D ABCC3 ATP13A4 SCN11A CLCA4 SLC4A8 ATP7B IPO8 SLC35D2 SLC5A9 ATP13A5 OCA2 OTOP3 ANO10 PKDREJ SLC7A11 SLC12A5 ITPR1 SLC5A11 ABCG4 PKD2L2 P2RX3 SLC15A1 KCNC3 SCN7A SLC28A2 OTOP1 SERINC3 CACNA1I PACC1 GJB7 SLC29A1 KCNH5 SLC35B1	7.23e-13	1180	154	36	GO:0022857
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC12A6 CACNA1C CACNA1D ATP13A4 SCN11A CLCA4 SLC4A8 ATP7B SLC5A9 ATP13A5 OCA2 OTOP3 ANO10 PKDREJ SLC12A5 ITPR1 SLC5A11 PKD2L2 P2RX3 SLC15A1 KCNC3 SCN7A SLC28A2 OTOP1 CACNA1I PACC1 SLC29A1 KCNH5	1.36e-11	793	154	28	GO:0015075
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC12A6 CACNA1C CACNA1D ABCC3 ATP13A4 SCN11A CLCA4 SLC4A8 ATP7B SLC5A9 OCA2 OTOP3 ANO10 PKDREJ SLC12A5 ITPR1 SLC5A11 PKD2L2 SLC15A1 KCNC3 SCN7A SLC28A2 OTOP1 CACNA1I PACC1 SLC29A1 KCNH5	2.73e-11	758	154	27	GO:0015318
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC12A6 CACNA1C CACNA1D ATP13A4 SCN11A SLC4A8 ATP7B SLC5A9 ATP13A5 OTOP3 ANO10 PKDREJ SLC12A5 ITPR1 SLC5A11 PKD2L2 P2RX3 SLC15A1 KCNC3 SCN7A SLC28A2 OTOP1 CACNA1I SLC29A1 KCNH5	5.05e-11	664	154	25	GO:0008324
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	NPC1 OR8K1 HCAR2 GPR21 GPR31 NTRK1 FPR2 PECAM1 LMBR1 OR14J1 F2RL2 S1PR1 OR2L13 BDKRB1 OR14A16 OR6N1 EDNRB LHCGR OR14K1 OR52B4 HCAR3 PTPRC P2RX3 ADGRG2 BRS3 PLXNC1 OR4A16 SCN7A HRH4 OPN5 OR10J4 TAS2R31 TAS2R43 TAS2R50 ADGRL3	1.59e-10	1353	154	35	GO:0004888
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR8K1 HCAR2 GPR21 GPR31 FPR2 OR14J1 F2RL2 S1PR1 OR2L13 BDKRB1 OR14A16 OR6N1 EDNRB LHCGR OR14K1 OR52B4 HCAR3 ADGRG2 BRS3 OR4A16 HRH4 OPN5 OR10J4 TAS2R31 TAS2R43 TAS2R50 ADGRL3	8.32e-10	884	154	27	GO:0004930
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	SLC12A6 CACNA1C CACNA1D ATP13A4 SCN11A SLC4A8 ATP7B SLC5A9 OTOP3 PKDREJ SLC12A5 ITPR1 SLC5A11 PKD2L2 SLC15A1 KCNC3 SCN7A SLC28A2 OTOP1 CACNA1I SLC29A1 KCNH5	3.02e-09	627	154	22	GO:0022890
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC12A6 CACNA1C CACNA1D ATP13A4 SCN11A SLC4A8 ATP7B SLC5A9 PKDREJ SLC12A5 ITPR1 SLC5A11 PKD2L2 KCNC3 SCN7A SLC28A2 CACNA1I SLC29A1 KCNH5	3.42e-09	465	154	19	GO:0046873
GeneOntologyMolecularFunction	channel activity	SLC12A6 CACNA1C CACNA1D SCN11A CLCA4 OCA2 OTOP3 ANO10 PKDREJ SLC12A5 ITPR1 PKD2L2 P2RX3 KCNC3 SCN7A OTOP1 CACNA1I PACC1 GJB7 KCNH5	4.24e-09	525	154	20	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	SLC12A6 CACNA1C CACNA1D SCN11A CLCA4 OCA2 OTOP3 ANO10 PKDREJ SLC12A5 ITPR1 PKD2L2 P2RX3 KCNC3 SCN7A OTOP1 CACNA1I PACC1 GJB7 KCNH5	4.37e-09	526	154	20	GO:0022803
GeneOntologyMolecularFunction	monoatomic ion channel activity	CACNA1C CACNA1D SCN11A CLCA4 OCA2 OTOP3 ANO10 PKDREJ ITPR1 PKD2L2 P2RX3 KCNC3 SCN7A OTOP1 CACNA1I PACC1 KCNH5	1.00e-07	459	154	17	GO:0005216
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC12A6 ABCC3 ATP13A4 SLC4A8 ATP7B IPO8 SLC35D2 SLC5A9 ATP13A5 SLC7A11 SLC12A5 SLC5A11 ABCG4 SLC15A1 SLC28A2 SLC29A1 SLC35B1	1.73e-07	477	154	17	GO:0022804
GeneOntologyMolecularFunction	monoatomic cation channel activity	CACNA1C CACNA1D SCN11A OTOP3 ANO10 PKDREJ ITPR1 PKD2L2 P2RX3 KCNC3 SCN7A OTOP1 CACNA1I KCNH5	4.51e-07	343	154	14	GO:0005261
GeneOntologyMolecularFunction	solute:monoatomic cation symporter activity	SLC12A6 SLC4A8 SLC5A9 SLC12A5 SLC5A11 SLC15A1 SLC28A2 SLC29A1	3.97e-06	119	154	8	GO:0015294
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC12A6 SLC4A8 SLC35D2 SLC5A9 SLC7A11 SLC12A5 SLC5A11 SLC15A1 SLC28A2 SLC29A1 SLC35B1	1.94e-05	296	154	11	GO:0015291
GeneOntologyMolecularFunction	symporter activity	SLC12A6 SLC4A8 SLC5A9 SLC12A5 SLC5A11 SLC15A1 SLC28A2 SLC29A1	2.18e-05	150	154	8	GO:0015293
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	SLC12A6 ATP13A4 SLC4A8 ATP7B SLC5A9 ATP13A5 SLC12A5 SLC5A11 SLC15A1 SLC28A2 SLC29A1	2.26e-05	301	154	11	GO:0022853
GeneOntologyMolecularFunction	chloride transmembrane transporter activity	SLC12A6 CLCA4 SLC4A8 OCA2 ANO10 SLC12A5 PACC1	5.28e-05	125	154	7	GO:0015108
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	SLC12A6 ABCC3 CLCA4 SLC4A8 OCA2 ANO10 SLC12A5 PACC1	5.55e-05	171	154	8	GO:0015103
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SCN11A SLC4A8 SLC5A9 SLC5A11 SCN7A SLC28A2 CACNA1I SLC29A1	5.55e-05	171	154	8	GO:0015081
GeneOntologyMolecularFunction	gated channel activity	CACNA1C CACNA1D CLCA4 ANO10 ITPR1 P2RX3 KCNC3 SCN7A CACNA1I PACC1 KCNH5	5.83e-05	334	154	11	GO:0022836
GeneOntologyMolecularFunction	nicotinic acid receptor activity	HCAR2 HCAR3	5.91e-05	2	154	2	GO:0070553
GeneOntologyMolecularFunction	carbohydrate derivative transmembrane transporter activity	ABCC3 SLC35D2 SLC28A2 SLC29A1 SLC35B1	9.15e-05	59	154	5	GO:1901505
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1C CACNA1D CACNA1I	1.54e-04	14	154	3	GO:0008331
GeneOntologyMolecularFunction	monoatomic anion transmembrane transporter activity	SLC12A6 CLCA4 SLC4A8 OCA2 ANO10 SLC12A5 PACC1	1.73e-04	151	154	7	GO:0008509
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNA1C CACNA1D ATP13A4 PKDREJ ITPR1 PKD2L2 CACNA1I	1.73e-04	151	154	7	GO:0015085
GeneOntologyMolecularFunction	UDP-glucose transmembrane transporter activity	SLC35D2 SLC35B1	1.76e-04	3	154	2	GO:0005460
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ABCC3 ATP13A4 ATP7B IPO8 ATP13A5 ABCG4	2.01e-04	109	154	6	GO:0042626
GeneOntologyMolecularFunction	adenylate cyclase activity	ADCY2 ADCY6 ADCY8	3.37e-04	18	154	3	GO:0004016
GeneOntologyMolecularFunction	nucleoside:sodium symporter activity	SLC28A2 SLC29A1	3.51e-04	4	154	2	GO:0005415
GeneOntologyMolecularFunction	purine nucleoside transmembrane transporter activity	SLC28A2 SLC29A1	3.51e-04	4	154	2	GO:0015211
GeneOntologyMolecularFunction	mediator complex binding	SMC3 NIPBL	3.51e-04	4	154	2	GO:0036033
GeneOntologyMolecularFunction	nucleobase:monoatomic cation symporter activity	SLC28A2 SLC29A1	3.51e-04	4	154	2	GO:0015391
GeneOntologyMolecularFunction	pyrimidine- and adenosine-specific:sodium symporter activity	SLC28A2 SLC29A1	3.51e-04	4	154	2	GO:0015389
GeneOntologyMolecularFunction	solute:sodium symporter activity	SLC4A8 SLC5A9 SLC5A11 SLC28A2 SLC29A1	4.09e-04	81	154	5	GO:0015370
GeneOntologyMolecularFunction	calcium channel activity	CACNA1C CACNA1D PKDREJ ITPR1 PKD2L2 CACNA1I	4.98e-04	129	154	6	GO:0005262
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in cardiac muscle cell action potential	CACNA1C CACNA1D	5.82e-04	5	154	2	GO:0086007
GeneOntologyMolecularFunction	calcium- and calmodulin-responsive adenylate cyclase activity	ADCY6 ADCY8	5.82e-04	5	154	2	GO:0008294
GeneOntologyMolecularFunction	G protein-coupled peptide receptor activity	FPR2 F2RL2 BDKRB1 EDNRB LHCGR BRS3	5.85e-04	133	154	6	GO:0008528
GeneOntologyMolecularFunction	nucleotide receptor activity	HCAR2 HCAR3 P2RX3	6.22e-04	22	154	3	GO:0016502
GeneOntologyMolecularFunction	purinergic nucleotide receptor activity	HCAR2 HCAR3 P2RX3	6.22e-04	22	154	3	GO:0001614
GeneOntologyMolecularFunction	peptide receptor activity	FPR2 F2RL2 BDKRB1 EDNRB LHCGR BRS3	7.66e-04	140	154	6	GO:0001653
GeneOntologyMolecularFunction	cyclase activity	ADCY2 ADCY6 ADCY8	8.08e-04	24	154	3	GO:0009975
GeneOntologyMolecularFunction	uridine transmembrane transporter activity	SLC28A2 SLC29A1	8.69e-04	6	154	2	GO:0015213
GeneOntologyMolecularFunction	chromo shadow domain binding	CHAF1A NIPBL	8.69e-04	6	154	2	GO:0070087
GeneOntologyMolecularFunction	phosphorus-oxygen lyase activity	ADCY2 ADCY6 ADCY8	9.13e-04	25	154	3	GO:0016849
GeneOntologyMolecularFunction	ATP-dependent activity	ABCC3 ATP13A4 ATP7B IPO8 MCM8 ATP13A5 UBA3 ATP9A ABCG4 MYO3A SMC3 CCT8 HFM1	9.65e-04	614	154	13	GO:0140657
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN11A SCN7A CACNA1I	1.03e-03	26	154	3	GO:0005248
GeneOntologyMolecularFunction	nucleobase-containing compound transmembrane transporter activity	SLC35D2 SLC28A2 SLC29A1 SLC35B1	1.11e-03	59	154	4	GO:0015932
GeneOntologyMolecularFunction	bitter taste receptor activity	TAS2R31 TAS2R43 TAS2R50	1.15e-03	27	154	3	GO:0033038
GeneOntologyMolecularFunction	D-glucose:sodium symporter activity	SLC5A9 SLC5A11	1.21e-03	7	154	2	GO:0005412
GeneOntologyMolecularFunction	pyrimidine nucleobase transmembrane transporter activity	SLC28A2 SLC29A1	1.21e-03	7	154	2	GO:0005350
GeneOntologyMolecularFunction	clathrin light chain binding	NSG2 NSG1	1.21e-03	7	154	2	GO:0032051
GeneOntologyMolecularFunction	pyrimidine nucleoside transmembrane transporter activity	SLC28A2 SLC29A1	1.61e-03	8	154	2	GO:0015214
GeneOntologyMolecularFunction	ATPase-coupled lipid transmembrane transporter activity	ABCC3 ABCG4	2.05e-03	9	154	2	GO:0034040
GeneOntologyMolecularFunction	potassium:chloride symporter activity	SLC12A6 SLC12A5	2.05e-03	9	154	2	GO:0015379
GeneOntologyMolecularFunction	taste receptor activity	TAS2R31 TAS2R43 TAS2R50	2.07e-03	33	154	3	GO:0008527
GeneOntologyMolecularFunction	ATP hydrolysis activity	ABCC3 ATP13A4 ATP7B MCM8 ATP13A5 ATP9A ABCG4 SMC3 CCT8 HFM1	2.27e-03	441	154	10	GO:0016887
GeneOntologyMolecularFunction	purine nucleobase transmembrane transporter activity	SLC28A2 SLC29A1	2.55e-03	10	154	2	GO:0005345
GeneOntologyMolecularFunction	nucleoside transmembrane transporter activity	SLC28A2 SLC29A1	2.55e-03	10	154	2	GO:0005337
GeneOntologyMolecularFunction	primary active transmembrane transporter activity	ABCC3 ATP13A4 ATP7B IPO8 ATP13A5 ABCG4	2.61e-03	178	154	6	GO:0015399
GeneOntologyMolecularFunction	P-type transmembrane transporter activity	ATP13A4 ATP7B ATP13A5	2.67e-03	36	154	3	GO:0140358
GeneOntologyMolecularFunction	P-type ion transporter activity	ATP13A4 ATP7B ATP13A5	2.67e-03	36	154	3	GO:0015662
GeneOntologyMolecularFunction	odorant binding	OR8K1 OR14J1 OR14A16 OR14K1 OR10J4	3.06e-03	127	154	5	GO:0005549
GeneOntologyMolecularFunction	polyamine transmembrane transporter activity	ATP13A4 ATP13A5	3.11e-03	11	154	2	GO:0015203
GeneOntologyMolecularFunction	nucleobase transmembrane transporter activity	SLC28A2 SLC29A1	3.11e-03	11	154	2	GO:0015205
GeneOntologyMolecularFunction	pyrimidine nucleotide-sugar transmembrane transporter activity	SLC35D2 SLC35B1	3.11e-03	11	154	2	GO:0015165
GeneOntologyMolecularFunction	ammonium channel activity	SLC12A6 SLC12A5	3.71e-03	12	154	2	GO:0008519
GeneOntologyMolecularFunction	chloride channel activity	CLCA4 OCA2 ANO10 PACC1	4.43e-03	86	154	4	GO:0005254
GeneOntologyMolecularFunction	nucleotide-sugar transmembrane transporter activity	SLC35D2 SLC35B1	5.06e-03	14	154	2	GO:0005338
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1C CACNA1D CACNA1I	5.36e-03	46	154	3	GO:0005245
GeneOntologyMolecularFunction	olfactory receptor activity	OR8K1 OR14J1 OR2L13 OR14A16 OR6N1 OR14K1 OR52B4 OR4A16 OR10J4	6.34e-03	431	154	9	GO:0004984
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	CACNA1C CACNA1D KCNC3 CACNA1I KCNH5	6.53e-03	152	154	5	GO:0022843
GeneOntologyMolecularFunction	bioactive lipid receptor activity	GPR31 S1PR1	6.61e-03	16	154	2	GO:0045125
GeneOntologyMolecularFunction	ligand-gated monoatomic anion channel activity	CLCA4 ANO10 PACC1	6.76e-03	50	154	3	GO:0099095
GeneOntologyMolecularFunction	carbohydrate:monoatomic cation symporter activity	SLC5A9 SLC5A11	7.45e-03	17	154	2	GO:0005402
GeneOntologyMolecularFunction	sodium channel activity	SCN11A SCN7A CACNA1I	7.54e-03	52	154	3	GO:0005272
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	CACNA1D OR8K1 HCAR2 SCN11A GPR21 GPR31 FPR2 OR14J1 F2RL2 ADCY2 S1PR1 OR2L13 BDKRB1 ADCY6 OR14A16 ADCY8 OR6N1 EDNRB ITPR1 LHCGR OR14K1 OR52B4 HCAR3 NSG2 ADGRG2 BRS3 OR4A16 NSG1 HRH4 OPN5 OR10J4 TAS2R31 TAS2R43 TAS2R50 ADGRL3	1.85e-10	1395	155	35	GO:0007186
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	SLC12A6 CACNA1C CACNA1D ABCC3 ATP13A4 SCN11A CLCA4 SLC4A8 ATP7B SLC5A9 ATP13A5 OCA2 OTOP3 ANO10 PKDREJ BDKRB1 EDNRB SLC12A5 ITPR1 LHCGR PTPRC PKD2L2 P2RX3 SLC15A1 KCNC3 ALG10 SCN7A OTOP1 CACNA1I PACC1 KCNH5	2.08e-10	1115	155	31	GO:0034220
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	SLC12A6 CACNA1C CACNA1D ATP13A4 SCN11A CLCA4 SLC4A8 ATP7B SLC5A9 OCA2 OTOP3 ANO10 PKDREJ BDKRB1 EDNRB SLC12A5 ITPR1 LHCGR PTPRC PKD2L2 P2RX3 SLC15A1 KCNC3 ALG10 SCN7A OTOP1 CACNA1I PACC1 KCNH5	4.91e-10	1017	155	29	GO:0098660
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	SLC12A6 CACNA1C CACNA1D ATP13A4 SCN11A SLC4A8 ATP7B SLC5A9 ATP13A5 OTOP3 ANO10 PKDREJ BDKRB1 EDNRB SLC12A5 ITPR1 LHCGR PTPRC PKD2L2 P2RX3 SLC15A1 KCNC3 ALG10 SCN7A OTOP1 CACNA1I KCNH5	1.91e-09	942	155	27	GO:0098655
GeneOntologyBiologicalProcess	monoatomic ion transport	SLC12A6 CACNA1C CACNA1D ABCC3 ATP13A4 SCN11A CLCA4 SLC4A8 ATP7B SLC5A9 ATP13A5 OCA2 OTOP3 ANO10 PKDREJ BDKRB1 EDNRB SLC12A5 ITPR1 SLC5A11 LHCGR PTPRC PKD2L2 P2RX3 SLC15A1 KCNC3 ALG10 SCN7A OTOP1 CACNA1I PACC1 CTNNB1 KCNH5	2.06e-09	1374	155	33	GO:0006811
GeneOntologyBiologicalProcess	monoatomic cation transport	SLC12A6 CACNA1C CACNA1D ATP13A4 SCN11A SLC4A8 ATP7B SLC5A9 ATP13A5 OTOP3 ANO10 PKDREJ BDKRB1 EDNRB SLC12A5 ITPR1 SLC5A11 LHCGR PTPRC PKD2L2 P2RX3 SLC15A1 KCNC3 ALG10 SCN7A OTOP1 CACNA1I CTNNB1 KCNH5	9.13e-09	1157	155	29	GO:0006812
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	SLC12A6 CACNA1C CACNA1D ATP13A4 SCN11A SLC4A8 ATP7B SLC5A9 OTOP3 PKDREJ BDKRB1 EDNRB SLC12A5 ITPR1 LHCGR PTPRC PKD2L2 P2RX3 SLC15A1 KCNC3 ALG10 SCN7A OTOP1 CACNA1I KCNH5	2.46e-08	922	155	25	GO:0098662
GeneOntologyBiologicalProcess	metal ion transport	SLC12A6 CACNA1C CACNA1D ATP13A4 SCN11A SLC4A8 ATP7B SLC5A9 PKDREJ BDKRB1 EDNRB SLC12A5 ITPR1 SLC5A11 LHCGR PTPRC PKD2L2 P2RX3 KCNC3 ALG10 SCN7A CACNA1I CTNNB1 KCNH5	4.55e-07	1000	155	24	GO:0030001
GeneOntologyBiologicalProcess	detection of stimulus	OR8K1 SCN11A NTRK1 OR14J1 PKDREJ OR2L13 OR14A16 OR6N1 OR14K1 OR52B4 PKD2L2 OR4A16 OTOP1 OPN5 OR10J4 TAS2R31 TAS2R43 CTNNB1 TAS2R50	2.14e-06	722	155	19	GO:0051606
GeneOntologyBiologicalProcess	behavioral response to chemical pain	SCN11A NTRK1 P2RX3	4.12e-06	5	155	3	GO:0061366
GeneOntologyBiologicalProcess	behavioral response to formalin induced pain	SCN11A NTRK1 P2RX3	4.12e-06	5	155	3	GO:0061368
GeneOntologyBiologicalProcess	positive regulation of cytosolic calcium ion concentration	CACNA1C FPR2 BDKRB1 ADCY8 EDNRB ITPR1 LHCGR P2RX3 HRH4 CACNA1I	7.77e-06	224	155	10	GO:0007204
GeneOntologyBiologicalProcess	calcium ion transmembrane transport	CACNA1C CACNA1D ATP13A4 SCN11A PKDREJ BDKRB1 EDNRB ITPR1 LHCGR PTPRC PKD2L2 P2RX3 CACNA1I	8.65e-06	392	155	13	GO:0070588
GeneOntologyBiologicalProcess	glycoprotein biosynthetic process	NPC1 MAN1A1 SLC35D2 TMEM106A LIPC TMTC3 ALG10 ST8SIA5 CTNNB1 DSEL ALG6 C1GALT1C1L	1.70e-05	357	155	12	GO:0009101
GeneOntologyBiologicalProcess	chemical homeostasis	NPC1 SLC12A6 CACNA1C CACNA1D ATP13A4 SLC4A8 GPR21 ATP7B TM9SF4 ATP13A5 OCA2 SLC7A11 BDKRB1 ADCY6 ADCY8 EDNRB SLC12A5 ITPR1 LHCGR ABCG4 LIPC PTPRC SCN7A SLC29A1	2.06e-05	1249	155	24	GO:0048878
GeneOntologyBiologicalProcess	monoatomic anion transmembrane transport	SLC12A6 ABCC3 CLCA4 SLC4A8 OCA2 ANO10 SLC12A5 PACC1	2.09e-05	153	155	8	GO:0098656
GeneOntologyBiologicalProcess	chloride transmembrane transport	SLC12A6 CLCA4 SLC4A8 OCA2 ANO10 SLC12A5 PACC1	2.21e-05	112	155	7	GO:1902476
GeneOntologyBiologicalProcess	calcium ion transport	CACNA1C CACNA1D ATP13A4 SCN11A PKDREJ BDKRB1 EDNRB ITPR1 LHCGR PTPRC PKD2L2 P2RX3 CACNA1I CTNNB1	3.13e-05	509	155	14	GO:0006816
GeneOntologyBiologicalProcess	calcium-mediated signaling	CACNA1C CACNA1D TPRG1L FPR2 EDNRB ITPR1 LHCGR PTPRC P2RX3 NR5A1	3.42e-05	266	155	10	GO:0019722
GeneOntologyBiologicalProcess	response to pain	SCN11A NTRK1 CAPN2 EDNRB P2RX3	3.99e-05	51	155	5	GO:0048265
GeneOntologyBiologicalProcess	carbohydrate derivative biosynthetic process	NPC1 MAN1A1 SLC35D2 ADCY2 ADCY6 ADCY8 TMEM106A LIPC TMTC3 ALG10 PIGW ST8SIA5 CTNNB1 DSEL ALG6 HACD1 C1GALT1C1L	4.04e-05	736	155	17	GO:1901137
GeneOntologyBiologicalProcess	chloride transport	SLC12A6 CLCA4 SLC4A8 OCA2 ANO10 SLC12A5 PACC1	5.22e-05	128	155	7	GO:0006821
GeneOntologyBiologicalProcess	thermosensory behavior	SCN11A SLC12A5	5.61e-05	2	155	2	GO:0040040
GeneOntologyBiologicalProcess	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	CACNA1D FPR2 ADCY2 S1PR1 ADCY6 ADCY8 LHCGR ADGRG2 HRH4 ADGRL3	6.29e-05	286	155	10	GO:0007188
GeneOntologyBiologicalProcess	cAMP biosynthetic process	ADCY2 ADCY6 ADCY8	6.57e-05	11	155	3	GO:0006171
GeneOntologyBiologicalProcess	inorganic anion transmembrane transport	SLC12A6 CLCA4 SLC4A8 OCA2 ANO10 SLC12A5 PACC1	6.99e-05	134	155	7	GO:0098661
GeneOntologyBiologicalProcess	monoatomic anion transport	SLC12A6 ABCC3 CLCA4 SLC4A8 OCA2 ANO10 SLC12A5 PACC1	7.47e-05	183	155	8	GO:0006820
GeneOntologyBiologicalProcess	regulation of adenylate cyclase activity	CACNA1C CACNA1D ADCY2 EDNRB LHCGR	8.11e-05	59	155	5	GO:0045761
GeneOntologyBiologicalProcess	monoatomic cation homeostasis	SLC12A6 CACNA1C ATP13A4 SLC4A8 ATP7B TM9SF4 ATP13A5 OCA2 BDKRB1 ADCY8 EDNRB SLC12A5 ITPR1 LHCGR PTPRC SCN7A	8.45e-05	705	155	16	GO:0055080
GeneOntologyBiologicalProcess	intracellular chemical homeostasis	SLC12A6 CACNA1C CACNA1D ATP13A4 SLC4A8 ATP7B TM9SF4 ATP13A5 OCA2 SLC7A11 BDKRB1 ADCY8 SLC12A5 ITPR1 LHCGR PTPRC SCN7A SLC29A1	9.22e-05	866	155	18	GO:0055082
GeneOntologyBiologicalProcess	behavioral response to pain	SCN11A NTRK1 CAPN2 P2RX3	9.36e-05	32	155	4	GO:0048266
GeneOntologyBiologicalProcess	glycoprotein metabolic process	NPC1 MAN1A1 SLC35D2 TMEM106A LIPC TMTC3 ALG10 ST8SIA5 CTNNB1 DSEL ALG6 C1GALT1C1L	1.02e-04	430	155	12	GO:0009100
GeneOntologyBiologicalProcess	monoatomic ion homeostasis	SLC12A6 CACNA1C ATP13A4 SLC4A8 ATP7B TM9SF4 ATP13A5 OCA2 BDKRB1 ADCY8 EDNRB SLC12A5 ITPR1 LHCGR PTPRC SCN7A	1.03e-04	717	155	16	GO:0050801
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR8K1 SCN11A NTRK1 OR14J1 OR2L13 OR14A16 OR6N1 OR14K1 OR52B4 OR4A16 OR10J4 TAS2R31 TAS2R43 TAS2R50	1.31e-04	582	155	14	GO:0050906
GeneOntologyBiologicalProcess	action potential	CACNA1C CACNA1D SCN11A TMEM161B P2RX3 KCNC3 SCN7A CACNA1I	1.43e-04	201	155	8	GO:0001508
GeneOntologyBiologicalProcess	membrane depolarization during action potential	CACNA1C CACNA1D SCN11A CACNA1I	1.50e-04	36	155	4	GO:0086010
GeneOntologyBiologicalProcess	sensory perception	CACNA1D OR8K1 SCN11A NTRK1 OR14J1 OR2L13 OR14A16 OR6N1 OR14K1 OR52B4 MYO3A P2RX3 OR4A16 ALG10 OPN5 OR10J4 TAS2R31 TAS2R43 TAS2R50 NIPBL	1.60e-04	1072	155	20	GO:0007600
GeneOntologyBiologicalProcess	regulation of cyclase activity	CACNA1C CACNA1D ADCY2 EDNRB LHCGR	1.71e-04	69	155	5	GO:0031279
GeneOntologyBiologicalProcess	intracellular monoatomic cation homeostasis	CACNA1C ATP13A4 SLC4A8 ATP7B TM9SF4 ATP13A5 OCA2 BDKRB1 ADCY8 SLC12A5 ITPR1 LHCGR PTPRC SCN7A	2.16e-04	611	155	14	GO:0030003
GeneOntologyBiologicalProcess	regulation of lyase activity	CACNA1C CACNA1D ADCY2 EDNRB LHCGR	2.24e-04	73	155	5	GO:0051339
GeneOntologyBiologicalProcess	positive regulation of adenylate cyclase activity	CACNA1C CACNA1D ADCY2 LHCGR	2.27e-04	40	155	4	GO:0045762
GeneOntologyBiologicalProcess	calcium ion transmembrane import into cytosol	CACNA1C CACNA1D BDKRB1 ITPR1 LHCGR PTPRC P2RX3 CACNA1I	2.42e-04	217	155	8	GO:0097553
GeneOntologyBiologicalProcess	detection of mechanical stimulus	SCN11A NTRK1 PKDREJ PKD2L2 CTNNB1	2.54e-04	75	155	5	GO:0050982
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR8K1 OR14J1 OR2L13 OR14A16 OR6N1 OR14K1 OR52B4 P2RX3 OR4A16 OR10J4 TAS2R31 TAS2R43 TAS2R50	2.57e-04	547	155	13	GO:0007606
GeneOntologyBiologicalProcess	intracellular monoatomic ion homeostasis	CACNA1C ATP13A4 SLC4A8 ATP7B TM9SF4 ATP13A5 OCA2 BDKRB1 ADCY8 SLC12A5 ITPR1 LHCGR PTPRC SCN7A	2.59e-04	622	155	14	GO:0006873
GeneOntologyBiologicalProcess	calcium ion transport into cytosol	CACNA1C LHCGR P2RX3 CACNA1I	2.75e-04	42	155	4	GO:0060402
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR8K1 OR14J1 OR2L13 OR14A16 OR6N1 OR14K1 OR52B4 OR4A16 OR10J4 TAS2R31 TAS2R43 TAS2R50	3.10e-04	485	155	12	GO:0050907
GeneOntologyBiologicalProcess	cellular response to forskolin	ADCY2 ADCY6 ADCY8	3.13e-04	18	155	3	GO:1904322
GeneOntologyBiologicalProcess	positive regulation of adiponectin secretion	HCAR2 HCAR3	3.33e-04	4	155	2	GO:0070165
GeneOntologyBiologicalProcess	UDP-glucose transmembrane transport	SLC35D2 SLC35B1	3.33e-04	4	155	2	GO:0015786
GeneOntologyBiologicalProcess	inosine transport	SLC28A2 SLC29A1	3.33e-04	4	155	2	GO:0035340
GeneOntologyBiologicalProcess	detection of external stimulus	SCN11A NTRK1 PKDREJ PKD2L2 OTOP1 OPN5 CTNNB1	3.40e-04	173	155	7	GO:0009581
GeneOntologyBiologicalProcess	detection of abiotic stimulus	SCN11A NTRK1 PKDREJ PKD2L2 OTOP1 OPN5 CTNNB1	3.64e-04	175	155	7	GO:0009582
GeneOntologyBiologicalProcess	response to forskolin	ADCY2 ADCY6 ADCY8	3.69e-04	19	155	3	GO:1904321
GeneOntologyBiologicalProcess	xenobiotic transmembrane transport	ABCC3 SLC28A2 SLC29A1	3.69e-04	19	155	3	GO:0006855
GeneOntologyBiologicalProcess	cellular homeostasis	SLC12A6 CACNA1C CACNA1D ATP13A4 SLC4A8 ATP7B TM9SF4 ATP13A5 OCA2 SLC7A11 BDKRB1 ADCY8 SLC12A5 ITPR1 LHCGR PTPRC SCN7A SLC29A1	4.23e-04	981	155	18	GO:0019725
GeneOntologyBiologicalProcess	inorganic anion transport	SLC12A6 CLCA4 SLC4A8 OCA2 ANO10 SLC12A5 PACC1	4.31e-04	180	155	7	GO:0015698
GeneOntologyBiologicalProcess	positive regulation of cyclase activity	CACNA1C CACNA1D ADCY2 LHCGR	4.62e-04	48	155	4	GO:0031281
GeneOntologyBiologicalProcess	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	FPR2 ADCY2 S1PR1 ADCY6 HRH4	4.79e-04	86	155	5	GO:0007193
GeneOntologyBiologicalProcess	positive regulation of lyase activity	CACNA1C CACNA1D ADCY2 LHCGR	5.00e-04	49	155	4	GO:0051349
GeneOntologyBiologicalProcess	cardiac muscle cell action potential	CACNA1C CACNA1D SCN11A TMEM161B SCN7A	5.06e-04	87	155	5	GO:0086001
GeneOntologyBiologicalProcess	phospholipase C-activating G protein-coupled receptor signaling pathway	FPR2 F2RL2 S1PR1 EDNRB ITPR1 LHCGR	5.11e-04	133	155	6	GO:0007200
GeneOntologyBiologicalProcess	adenosine transport	SLC28A2 SLC29A1	5.53e-04	5	155	2	GO:0032238
GeneOntologyBiologicalProcess	oligopeptide import across plasma membrane	SLC7A11 SLC15A1	5.53e-04	5	155	2	GO:0140205
GeneOntologyBiologicalProcess	dipeptide import across plasma membrane	SLC7A11 SLC15A1	5.53e-04	5	155	2	GO:0140206
GeneOntologyBiologicalProcess	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	CACNA1C CACNA1D	5.53e-04	5	155	2	GO:1904879
GeneOntologyBiologicalProcess	purine nucleoside transmembrane transport	SLC28A2 SLC29A1	5.53e-04	5	155	2	GO:0015860
GeneOntologyBiologicalProcess	response to mechanical stimulus	SCN11A NTRK1 CAPN2 PKDREJ BDKRB1 PKD2L2 P2RX3 CTNNB1	5.73e-04	247	155	8	GO:0009612
GeneOntologyBiologicalProcess	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ADCY2 S1PR1 ADCY6 ADCY8 LHCGR ADGRG2 ADGRL3	6.14e-04	191	155	7	GO:0007189
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR8K1 OR14J1 OR2L13 OR14A16 OR6N1 OR14K1 OR52B4 OR4A16 OR10J4 TAS2R31 TAS2R43 TAS2R50	6.18e-04	524	155	12	GO:0009593
GeneOntologyBiologicalProcess	cyclic nucleotide biosynthetic process	ADCY2 ADCY6 ADCY8	6.60e-04	23	155	3	GO:0009190
GeneOntologyBiologicalProcess	positive regulation of protein secretion	CACNA1C CACNA1D HCAR2 F2RL2 ADCY8 ITPR1 HCAR3	6.73e-04	194	155	7	GO:0050714
GeneOntologyBiologicalProcess	maintenance of location in cell	CACNA1C ATP7B BDKRB1 ADCY6 ITPR1 LHCGR PTPRC NR5A1	7.81e-04	259	155	8	GO:0051651
GeneOntologyBiologicalProcess	carbohydrate derivative transport	ABCC3 SLC35D2 SLC28A2 SLC29A1 SLC35B1	7.92e-04	96	155	5	GO:1901264
GeneOntologyBiologicalProcess	pyrimidine nucleoside transport	SLC28A2 SLC29A1	8.25e-04	6	155	2	GO:0015864
GeneOntologyBiologicalProcess	uridine transmembrane transport	SLC28A2 SLC29A1	8.25e-04	6	155	2	GO:0015862
GeneOntologyBiologicalProcess	phosphatidylserine metabolic process	MBOAT2 LIPC SERINC1	8.48e-04	25	155	3	GO:0006658
GeneOntologyBiologicalProcess	cAMP metabolic process	ADCY2 ADCY6 ADCY8	8.48e-04	25	155	3	GO:0046058
GeneOntologyBiologicalProcess	inorganic ion homeostasis	SLC12A6 CACNA1C ATP13A4 ATP7B ATP13A5 BDKRB1 ADCY8 EDNRB SLC12A5 ITPR1 LHCGR PTPRC SCN7A	8.59e-04	622	155	13	GO:0098771
GeneOntologyBiologicalProcess	positive regulation of hormone secretion	CACNA1C CACNA1D HCAR2 F2RL2 ADCY8 ITPR1 HCAR3	9.31e-04	205	155	7	GO:0046887
GeneOntologyBiologicalProcess	sequestering of calcium ion	CACNA1C ATP7B BDKRB1 ITPR1 LHCGR PTPRC	1.06e-03	153	155	6	GO:0051208
GeneOntologyBiologicalProcess	regulation of membrane potential	CACNA1C CACNA1D SCN11A SLC4A8 TMEM161B TSPAN9 P2RX3 KCNC3 SCN7A CACNA1I SLC29A1 KCNH5	1.08e-03	559	155	12	GO:0042391
GeneOntologyBiologicalProcess	positive regulation of calcium ion transport	CACNA1C CACNA1D BDKRB1 ITPR1 LHCGR P2RX3	1.10e-03	154	155	6	GO:0051928
GeneOntologyBiologicalProcess	establishment of mitotic sister chromatid cohesion	SMC3 NIPBL	1.15e-03	7	155	2	GO:0034087
GeneOntologyBiologicalProcess	pyrimidine nucleobase transport	SLC28A2 SLC29A1	1.15e-03	7	155	2	GO:0015855
GeneOntologyBiologicalProcess	cardiac muscle cell action potential involved in contraction	CACNA1C CACNA1D SCN11A SCN7A	1.22e-03	62	155	4	GO:0086002
GeneOntologyBiologicalProcess	response to abiotic stimulus	SLC12A6 CACNA1C SCN11A GPR31 TM9SF4 NTRK1 CAPN2 PKDREJ SLC7A11 BDKRB1 SLC12A5 ITPR1 PTPRC PKD2L2 P2RX3 SCN7A OTOP1 OPN5 CTNNB1 NIPBL SLC29A1	1.33e-03	1361	155	21	GO:0009628
GeneOntologyBiologicalProcess	xenobiotic transport	ABCC3 ATP7B SLC28A2 SLC29A1	1.37e-03	64	155	4	GO:0042908
GeneOntologyBiologicalProcess	positive regulation of calcium ion transmembrane transport	CACNA1C CACNA1D BDKRB1 LHCGR P2RX3	1.40e-03	109	155	5	GO:1904427
GeneOntologyBiologicalProcess	phasic smooth muscle contraction	SCN11A EDNRB P2RX3	1.46e-03	30	155	3	GO:0014821
GeneOntologyBiologicalProcess	nucleoside transmembrane transport	SLC28A2 SLC29A1	1.53e-03	8	155	2	GO:1901642
GeneOntologyBiologicalProcess	dipeptide transport	SLC7A11 SLC15A1	1.53e-03	8	155	2	GO:0042938
GeneOntologyBiologicalProcess	adiponectin secretion	HCAR2 HCAR3	1.53e-03	8	155	2	GO:0070162
GeneOntologyBiologicalProcess	regulation of adiponectin secretion	HCAR2 HCAR3	1.53e-03	8	155	2	GO:0070163
GeneOntologyBiologicalProcess	purine nucleobase transmembrane transport	SLC28A2 SLC29A1	1.53e-03	8	155	2	GO:1904823
GeneOntologyBiologicalProcess	dipeptide transmembrane transport	SLC7A11 SLC15A1	1.53e-03	8	155	2	GO:0035442
GeneOntologyBiologicalProcess	chemosensory behavior	SCN11A NTRK1 P2RX3	1.60e-03	31	155	3	GO:0007635
GeneOntologyBiologicalProcess	intracellular calcium ion homeostasis	CACNA1C ATP13A4 ATP7B ATP13A5 BDKRB1 ADCY8 ITPR1 LHCGR PTPRC	1.61e-03	359	155	9	GO:0006874
GeneOntologyCellularComponent	dendrite	CACNA1C CACNA1D SLC4A8 NTRK1 CAPN2 NUMA1 ARFGEF2 TMEM185A ADCY2 ADCY8 SLC12A5 ITPR1 P2RX3 NSG2 KCNC3 NSG1 HRH4 CTNNB1	7.53e-05	858	156	18	GO:0030425
GeneOntologyCellularComponent	dendritic tree	CACNA1C CACNA1D SLC4A8 NTRK1 CAPN2 NUMA1 ARFGEF2 TMEM185A ADCY2 ADCY8 SLC12A5 ITPR1 P2RX3 NSG2 KCNC3 NSG1 HRH4 CTNNB1	7.76e-05	860	156	18	GO:0097447
GeneOntologyCellularComponent	apical part of cell	SLC12A6 CACNA1D CLCA4 SLC4A8 ATP7B NUMA1 F2RL2 SLC7A11 ADCY8 SLC5A11 SLC15A1 ADGRG2 CTNNB1 SLC29A1	1.46e-04	592	156	14	GO:0045177
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN11A SCN7A CACNA1I	2.57e-04	17	156	3	GO:0001518
GeneOntologyCellularComponent	somatodendritic compartment	CACNA1C CACNA1D SCN11A SLC4A8 NTRK1 CAPN2 NUMA1 ARFGEF2 TMEM185A ADCY2 ADCY8 SLC12A5 ITPR1 P2RX3 NSG2 KCNC3 BRS3 NSG1 HRH4 WDFY3 CTNNB1	3.24e-04	1228	156	21	GO:0036477
GeneOntologyCellularComponent	late endosome membrane	NPC1 ATP13A4 NTRK1 ATP13A5 ATP9A NSG2 NSG1	4.00e-04	179	156	7	GO:0031902
GeneOntologyCellularComponent	membrane raft	NPC1 CACNA1C MYADM PECAM1 CAPN2 ADCY2 S1PR1 ADCY8 PTPRC CTNNB1	4.01e-04	362	156	10	GO:0045121
GeneOntologyCellularComponent	membrane microdomain	NPC1 CACNA1C MYADM PECAM1 CAPN2 ADCY2 S1PR1 ADCY8 PTPRC CTNNB1	4.19e-04	364	156	10	GO:0098857
GeneOntologyCellularComponent	synaptic membrane	CACNA1C CACNA1D SCN11A SLC4A8 ADCY8 SLC12A5 ITPR1 P2RX3 NSG2 KCNC3 NSG1 CTNNB1 ADGRL3	4.43e-04	583	156	13	GO:0097060
GeneOntologyCellularComponent	vesicle membrane	NPC1 ATP13A4 SLC4A8 TPRG1L DSC1 NTRK1 FPR2 PECAM1 CEACAM3 LAIR1 ATP13A5 OCA2 ATP9A ADCY8 ITPR1 ABCG4 PTPRC NSG2 SBF2 NSG1 SLC28A2	8.71e-04	1325	156	21	GO:0012506
GeneOntologyCellularComponent	apical plasma membrane	SLC12A6 CACNA1D CLCA4 SLC4A8 F2RL2 ADCY8 SLC5A11 SLC15A1 ADGRG2 CTNNB1 SLC29A1	1.10e-03	487	156	11	GO:0016324
GeneOntologyCellularComponent	presynaptic membrane	CACNA1C CACNA1D SCN11A SLC4A8 ADCY8 P2RX3 KCNC3 CTNNB1	1.15e-03	277	156	8	GO:0042734
GeneOntologyCellularComponent	late endosome	NPC1 ATP13A4 ATP7B NTRK1 ATP13A5 ATP9A LIPC NSG2 NSG1	1.24e-03	348	156	9	GO:0005770
GeneOntologyCellularComponent	sodium channel complex	SCN11A SCN7A CACNA1I	1.29e-03	29	156	3	GO:0034706
GeneOntologyCellularComponent	cell body	CACNA1C CACNA1D SCN11A SLC4A8 NTRK1 CAPN2 NUMA1 ADCY8 SLC12A5 ITPR1 P2RX3 KCNC3 BRS3 TMEM132E CCT8 WDFY3	1.61e-03	929	156	16	GO:0044297
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	NPC1 ATP13A4 SLC4A8 TPRG1L DSC1 NTRK1 FPR2 PECAM1 CEACAM3 LAIR1 ATP13A5 OCA2 ATP9A ADCY8 ITPR1 ABCG4 PTPRC NSG2 SBF2 NSG1	1.77e-03	1307	156	20	GO:0030659
GeneOntologyCellularComponent	cation channel complex	CACNA1C CACNA1D SCN11A KCNC3 SCN7A CACNA1I KCNH5	1.96e-03	235	156	7	GO:0034703
GeneOntologyCellularComponent	microvillus	SLC7A11 ADCY6 LIPC OTOP1 CTNNB1	2.31e-03	123	156	5	GO:0005902
MousePheno	abnormal touch/ nociception	NPC1 SLC12A6 CACNA1C ABCC3 SCN11A NTRK1 BDKRB1 ADCY8 EDNRB SLC12A5 P2RX3 TMEM132E XPOT	7.10e-06	376	109	13	MP:0001968
MousePheno	abnormal pain threshold	NPC1 SLC12A6 CACNA1C ABCC3 SCN11A NTRK1 BDKRB1 ADCY8 EDNRB SLC12A5 P2RX3	7.37e-06	267	109	11	MP:0001970
MousePheno	abnormal chemical nociception	SLC12A6 CACNA1C NTRK1 ADCY8 P2RX3	2.24e-05	44	109	5	MP:0002735
MousePheno	hypoalgesia	NPC1 CACNA1C NTRK1 BDKRB1 ADCY8 EDNRB SLC12A5 P2RX3	5.43e-05	170	109	8	MP:0003043
MousePheno	small ovary	NPC1 MCM8 MCMDC2 LHCGR LIPC WDR11 HFM1 NR5A1	7.51e-05	178	109	8	MP:0001127
Domain	7tm_1	OR8K1 HCAR2 GPR21 GPR31 FPR2 OR14J1 F2RL2 S1PR1 OR2L13 BDKRB1 OR14A16 OR6N1 EDNRB LHCGR OR14K1 OR52B4 HCAR3 BRS3 OR4A16 HRH4 OPN5	2.25e-07	677	156	21	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR8K1 HCAR2 GPR21 GPR31 FPR2 OR14J1 F2RL2 S1PR1 OR2L13 BDKRB1 OR14A16 OR6N1 EDNRB LHCGR OR14K1 OR52B4 HCAR3 BRS3 OR4A16 HRH4 OPN5	2.73e-07	685	156	21	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR8K1 HCAR2 GPR21 GPR31 FPR2 OR14J1 F2RL2 S1PR1 OR2L13 BDKRB1 OR14A16 OR6N1 EDNRB LHCGR OR14K1 OR52B4 HCAR3 BRS3 OR4A16 HRH4 OPN5	3.15e-07	691	156	21	PS50262
Domain	GPCR_Rhodpsn	OR8K1 HCAR2 GPR21 GPR31 FPR2 OR14J1 F2RL2 S1PR1 OR2L13 BDKRB1 OR14A16 OR6N1 EDNRB LHCGR OR14K1 OR52B4 HCAR3 BRS3 OR4A16 HRH4 OPN5	3.22e-07	692	156	21	IPR000276
Domain	GPCR_Rhodpsn_7TM	OR8K1 HCAR2 GPR21 GPR31 FPR2 OR14J1 F2RL2 S1PR1 OR2L13 BDKRB1 OR14A16 OR6N1 EDNRB LHCGR OR52B4 HCAR3 BRS3 OR4A16 HRH4 OPN5	8.16e-07	670	156	20	IPR017452
Domain	Ion_trans_dom	CACNA1C CACNA1D SCN11A ITPR1 KCNC3 SCN7A CACNA1I KCNH5	5.15e-06	114	156	8	IPR005821
Domain	Ion_trans	CACNA1C CACNA1D SCN11A ITPR1 KCNC3 SCN7A CACNA1I KCNH5	5.15e-06	114	156	8	PF00520
Domain	Channel_four-helix_dom	CACNA1C CACNA1D SCN11A KCNC3 SCN7A CACNA1I	7.87e-06	57	156	6	IPR027359
Domain	-	CACNA1C CACNA1D SCN11A KCNC3 SCN7A CACNA1I	7.87e-06	57	156	6	1.20.120.350
Domain	Adcy_conserved_dom	ADCY2 ADCY6 ADCY8	1.12e-05	6	156	3	IPR009398
Domain	DUF1053	ADCY2 ADCY6 ADCY8	1.12e-05	6	156	3	PF06327
Domain	AC_N	ADCY2 ADCY6 ADCY8	3.10e-05	8	156	3	IPR032628
Domain	Adcy	ADCY2 ADCY6 ADCY8	3.10e-05	8	156	3	IPR030672
Domain	AC_N	ADCY2 ADCY6 ADCY8	3.10e-05	8	156	3	PF16214
Domain	VDCCAlpha1	CACNA1C CACNA1D CACNA1I	6.57e-05	10	156	3	IPR002077
Domain	HCAR2/3_rcpt	HCAR2 HCAR3	6.93e-05	2	156	2	IPR028017
Domain	-	ATP13A4 ATP7B ATP13A5 ATP9A	1.40e-04	32	156	4	3.40.1110.10
Domain	-	ATP13A4 ATP7B ATP13A5 ATP9A	1.40e-04	32	156	4	2.70.150.10
Domain	ATPase_P-typ_cyto_domN	ATP13A4 ATP7B ATP13A5 ATP9A	2.00e-04	35	156	4	IPR023299
Domain	Calcyon	NSG2 NSG1	2.07e-04	3	156	2	PF06387
Domain	CAC1F_C	CACNA1C CACNA1D	2.07e-04	3	156	2	IPR031688
Domain	Calcyon_neuron-sp	NSG2 NSG1	2.07e-04	3	156	2	IPR009431
Domain	CAC1F_C	CACNA1C CACNA1D	2.07e-04	3	156	2	PF16885
Domain	Otopetrin	OTOP3 OTOP1	2.07e-04	3	156	2	PF03189
Domain	Otopetrin	OTOP3 OTOP1	2.07e-04	3	156	2	IPR004878
Domain	ATPase_P-typ_P_site	ATP13A4 ATP7B ATP13A5 ATP9A	2.24e-04	36	156	4	IPR018303
Domain	P_typ_ATPase	ATP13A4 ATP7B ATP13A5 ATP9A	2.24e-04	36	156	4	IPR001757
Domain	ATPASE_E1_E2	ATP13A4 ATP7B ATP13A5 ATP9A	2.24e-04	36	156	4	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP13A4 ATP7B ATP13A5 ATP9A	2.50e-04	37	156	4	IPR008250
Domain	E1-E2_ATPase	ATP13A4 ATP7B ATP13A5 ATP9A	2.50e-04	37	156	4	PF00122
Domain	A/G_cyclase_CS	ADCY2 ADCY6 ADCY8	3.57e-04	17	156	3	IPR018297
Domain	TM_Fragile-X-F-assoc	TMEM185B TMEM185A	4.11e-04	4	156	2	IPR019396
Domain	Tmemb_185A	TMEM185B TMEM185A	4.11e-04	4	156	2	PF10269
Domain	P5-ATPase	ATP13A4 ATP13A5	4.11e-04	4	156	2	PF12409
Domain	VDCC_L_a1su	CACNA1C CACNA1D	4.11e-04	4	156	2	IPR005446
Domain	KCL_cotranspt	SLC12A6 SLC12A5	4.11e-04	4	156	2	IPR000076
Domain	-	ADCY2 ADCY6 ADCY8	4.25e-04	18	156	3	3.30.70.1230
Domain	Nucleotide_cyclase	ADCY2 ADCY6 ADCY8	4.25e-04	18	156	3	IPR029787
Domain	Guanylate_cyc	ADCY2 ADCY6 ADCY8	5.02e-04	19	156	3	PF00211
Domain	GUANYLATE_CYCLASE_2	ADCY2 ADCY6 ADCY8	5.02e-04	19	156	3	PS50125
Domain	A/G_cyclase	ADCY2 ADCY6 ADCY8	5.02e-04	19	156	3	IPR001054
Domain	GUANYLATE_CYCLASE_1	ADCY2 ADCY6 ADCY8	5.02e-04	19	156	3	PS00452
Domain	CYCc	ADCY2 ADCY6 ADCY8	5.02e-04	19	156	3	SM00044
Domain	TMEM132D_N	TMEM132C TMEM132E	6.82e-04	5	156	2	PF15705
Domain	TMEM132D_C	TMEM132C TMEM132E	6.82e-04	5	156	2	PF15706
Domain	TMEM132_M	TMEM132C TMEM132E	6.82e-04	5	156	2	IPR031437
Domain	TMEM132_C	TMEM132C TMEM132E	6.82e-04	5	156	2	IPR031436
Domain	TMEM132_N	TMEM132C TMEM132E	6.82e-04	5	156	2	IPR031435
Domain	TDE1/TMS	SERINC1 SERINC3	6.82e-04	5	156	2	IPR005016
Domain	P-type_TPase_V	ATP13A4 ATP13A5	6.82e-04	5	156	2	IPR006544
Domain	TMEM132	TMEM132C TMEM132E	6.82e-04	5	156	2	IPR026307
Domain	TMEM132	TMEM132C TMEM132E	6.82e-04	5	156	2	PF16070
Domain	PKD_2	PKDREJ PKD2L2	6.82e-04	5	156	2	IPR003915
Domain	DUF4704	NBEAL1 WDFY3	6.82e-04	5	156	2	IPR031570
Domain	Serinc	SERINC1 SERINC3	6.82e-04	5	156	2	PF03348
Domain	DUF4704	NBEAL1 WDFY3	6.82e-04	5	156	2	PF15787
Domain	AA-permease/SLC12A_dom	SLC12A6 SLC7A11 SLC12A5	7.83e-04	22	156	3	IPR004841
Domain	AA_permease	SLC12A6 SLC7A11 SLC12A5	7.83e-04	22	156	3	PF00324
Domain	PH_BEACH	NBEAL1 WDFY3	1.02e-03	6	156	2	PF14844
Domain	TAS2R	TAS2R31 TAS2R43 TAS2R50	1.29e-03	26	156	3	PF05296
Domain	T2R	TAS2R31 TAS2R43 TAS2R50	1.29e-03	26	156	3	IPR007960
Domain	Ca_chan_IQ	CACNA1C CACNA1D	1.42e-03	7	156	2	SM01062
Domain	Ca_chan_IQ	CACNA1C CACNA1D	1.42e-03	7	156	2	PF08763
Domain	SLC12A_fam	SLC12A6 SLC12A5	1.42e-03	7	156	2	IPR004842
Domain	VDCC_a1su_IQ	CACNA1C CACNA1D	1.42e-03	7	156	2	IPR014873
Domain	GPHH	CACNA1C CACNA1D	1.42e-03	7	156	2	PF16905
Domain	GPHH_dom	CACNA1C CACNA1D	1.42e-03	7	156	2	IPR031649
Domain	SLC12_C	SLC12A6 SLC12A5	1.88e-03	8	156	2	IPR018491
Domain	PH-BEACH_dom	NBEAL1 WDFY3	1.88e-03	8	156	2	IPR023362
Domain	-	NBEAL1 WDFY3	1.88e-03	8	156	2	2.30.29.40
Domain	PH_BEACH	NBEAL1 WDFY3	1.88e-03	8	156	2	PS51783
Domain	SLC12	SLC12A6 SLC12A5	1.88e-03	8	156	2	PF03522
Domain	-	ATP13A4 ATP7B ATP13A5 ATP9A	2.02e-03	64	156	4	3.40.50.1000
Domain	ARM-type_fold	IPO8 NBEAL1 ARFGEF2 PPP4R3A ITPR1 WDFY3 CTNNB1 NIPBL XPOT	2.22e-03	339	156	9	IPR016024
Domain	MCM	MCM8 MCMDC2	2.40e-03	9	156	2	SM00350
Domain	MCM_dom	MCM8 MCMDC2	2.40e-03	9	156	2	IPR001208
Domain	BEACH	NBEAL1 WDFY3	2.40e-03	9	156	2	PS50197
Domain	Beach	NBEAL1 WDFY3	2.40e-03	9	156	2	PF02138
Domain	-	NBEAL1 WDFY3	2.40e-03	9	156	2	1.10.1540.10
Domain	Beach	NBEAL1 WDFY3	2.40e-03	9	156	2	SM01026
Domain	BEACH_dom	NBEAL1 WDFY3	2.40e-03	9	156	2	IPR000409
Domain	MCM	MCM8 MCMDC2	2.40e-03	9	156	2	IPR031327
Domain	MCM	MCM8 MCMDC2	2.40e-03	9	156	2	PF00493
Domain	GPS	PKDREJ ADGRG2 ADGRL3	2.83e-03	34	156	3	SM00303
Domain	Na_channel_asu	SCN11A SCN7A	2.99e-03	10	156	2	IPR001696
Domain	Na_trans_assoc	SCN11A SCN7A	2.99e-03	10	156	2	IPR010526
Domain	Na_trans_assoc	SCN11A SCN7A	2.99e-03	10	156	2	PF06512
Domain	GPS	PKDREJ ADGRG2 ADGRL3	3.61e-03	37	156	3	IPR000203
Domain	NA_SOLUT_SYMP_1	SLC5A9 SLC5A11	3.63e-03	11	156	2	PS00456
Domain	PKD_channel	PKDREJ PKD2L2	3.63e-03	11	156	2	PF08016
Domain	PKD1_2_channel	PKDREJ PKD2L2	3.63e-03	11	156	2	IPR013122
Domain	HAD-like_dom	ATP13A4 ATP7B ATP13A5 ATP9A	4.33e-03	79	156	4	IPR023214
Domain	SSF	SLC5A9 SLC5A11	4.33e-03	12	156	2	PF00474
Domain	NA_SOLUT_SYMP_2	SLC5A9 SLC5A11	4.33e-03	12	156	2	PS00457
Domain	Na/solute_symporter	SLC5A9 SLC5A11	4.33e-03	12	156	2	IPR001734
Domain	NA_SOLUT_SYMP_3	SLC5A9 SLC5A11	4.33e-03	12	156	2	PS50283
Domain	SSD	NPC1 ZDHHC22	5.09e-03	13	156	2	IPR000731
Domain	SSD	NPC1 ZDHHC22	5.09e-03	13	156	2	PS50156
Domain	BTB-kelch_protein	KLHL40 KLHL9 KLHL15	5.52e-03	43	156	3	IPR017096
Domain	IBN_N	IPO8 XPOT	6.78e-03	15	156	2	PF03810
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	NPC1 SLC12A6 ABCC3 ATP13A4 CLCA4 SLC4A8 ATP7B SLC35D2 SLC5A9 ATP13A5 ANO10 ATP9A SLC7A11 ADCY2 ADCY6 ADCY8 SLC12A5 SLC5A11 ABCG4 LSR LIPC SLC15A1 SLC28A2 SLC29A1	4.43e-09	736	115	24	M27287
Pathway	REACTOME_G_ALPHA_I_SIGNALLING_EVENTS	HCAR2 GPR31 FPR2 ADCY2 BDKRB1 ADCY6 ADCY8 ITPR1 HCAR3 HRH4 OPN5 TAS2R31 TAS2R43 TAS2R50	2.61e-07	314	115	14	M600
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	NPC1 SLC12A6 ABCC3 ATP13A4 CLCA4 SLC4A8 ATP7B SLC35D2 SLC5A9 ATP13A5 ANO10 ATP9A SLC7A11 SLC12A5 SLC5A11 ABCG4 LIPC SLC15A1 SLC28A2 SLC29A1	5.59e-07	681	115	20	MM14985
Pathway	REACTOME_G_ALPHA_I_SIGNALLING_EVENTS	HCAR2 GPR31 FPR2 ADCY2 BDKRB1 ADCY6 ADCY8 HCAR3 HRH4 OPN5 TAS2R31 TAS2R43 TAS2R50	6.51e-07	289	115	13	MM15057
Pathway	REACTOME_SIGNALING_BY_GPCR	HCAR2 GPR31 FPR2 F2RL2 ADCY2 S1PR1 BDKRB1 ADCY6 ADCY8 EDNRB ITPR1 LHCGR HCAR3 BRS3 HRH4 OPN5 TAS2R31 TAS2R43 TAS2R50	1.09e-06	646	115	19	MM14962
Pathway	KEGG_CALCIUM_SIGNALING_PATHWAY	CACNA1C CACNA1D ADCY2 BDKRB1 ADCY8 EDNRB ITPR1 LHCGR P2RX3 CACNA1I	1.90e-06	178	115	10	M2890
Pathway	REACTOME_GPCR_LIGAND_BINDING	HCAR2 GPR31 FPR2 F2RL2 S1PR1 BDKRB1 EDNRB LHCGR HCAR3 BRS3 HRH4 OPN5 TAS2R31 TAS2R43 TAS2R50	2.13e-06	430	115	15	MM15160
Pathway	REACTOME_SIGNALING_BY_GPCR	HCAR2 GPR31 FPR2 F2RL2 ADCY2 S1PR1 BDKRB1 ADCY6 ADCY8 EDNRB ITPR1 LHCGR HCAR3 BRS3 HRH4 OPN5 TAS2R31 TAS2R43 TAS2R50	3.71e-06	702	115	19	M746
Pathway	REACTOME_GPCR_LIGAND_BINDING	HCAR2 GPR31 FPR2 F2RL2 S1PR1 BDKRB1 EDNRB LHCGR HCAR3 BRS3 HRH4 OPN5 TAS2R31 TAS2R43 TAS2R50	5.24e-06	463	115	15	M507
Pathway	KEGG_MEDICUS_REFERENCE_LHCGR_GNAS_PKA_SIGNALING_PATHWAY	ADCY2 ADCY6 ADCY8 LHCGR	7.09e-06	16	115	4	M47645
Pathway	WP_GPCRS_NONODORANT	HCAR2 F2RL2 S1PR1 BDKRB1 EDNRB LHCGR HCAR3 ADGRG2 HRH4 OPN5 ADGRL3	1.10e-05	266	115	11	MM15843
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	HCAR2 GPR31 FPR2 F2RL2 S1PR1 BDKRB1 EDNRB LHCGR HCAR3 BRS3 HRH4 OPN5	1.58e-05	330	115	12	M18334
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	HCAR2 GPR31 FPR2 F2RL2 S1PR1 BDKRB1 EDNRB LHCGR HCAR3 BRS3 HRH4 OPN5	1.73e-05	333	115	12	MM14963
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC12A6 SLC4A8 SLC35D2 SLC5A9 SLC7A11 SLC12A5 SLC5A11 SLC15A1 SLC28A2 SLC29A1	2.46e-05	238	115	10	MM15076
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC12A6 SLC4A8 SLC35D2 SLC5A9 SLC7A11 SLC12A5 SLC5A11 SLC15A1 SLC28A2 SLC29A1	3.62e-05	249	115	10	M5988
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	GPR21 GPR31 FPR2 OR14J1 F2RL2 BDKRB1 EDNRB LHCGR HCAR3 BRS3	5.22e-05	260	115	10	M39397
Pathway	REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY	ADCY2 ADCY6 ADCY8	6.09e-05	10	115	3	M19522
Pathway	REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY	ADCY2 ADCY6 ADCY8	6.09e-05	10	115	3	MM14668
Pathway	KEGG_TASTE_TRANSDUCTION	ADCY6 ADCY8 TAS2R31 TAS2R43 TAS2R50	6.34e-05	52	115	5	M5785
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_GNAS_TO_ACTH_CORTISOL_SIGNALING_PATHWAY	ADCY2 ADCY6 ADCY8 NR5A1	8.53e-05	29	115	4	M47515
Pathway	KEGG_MEDICUS_VARIANT_CYP11B1_CYP11B2_FUSION_TO_ACTH_CORTISOL_SIGNALING_PATHWAY	ADCY2 ADCY6 ADCY8 NR5A1	1.12e-04	31	115	4	M47507
Pathway	KEGG_MEDICUS_REFERENCE_ACTH_CORTISOL_SIGNALING_PATHWAY	ADCY2 ADCY6 ADCY8 NR5A1	1.27e-04	32	115	4	M47506
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	HCAR2 FPR2 F2RL2 BDKRB1 EDNRB LHCGR HCAR3 BRS3	1.40e-04	186	115	8	MM15994
Pathway	KEGG_GNRH_SIGNALING_PATHWAY	CACNA1C CACNA1D ADCY2 ADCY6 ADCY8 ITPR1	1.75e-04	101	115	6	M1979
Pathway	REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY	ADCY2 ADCY6 ADCY8	1.80e-04	14	115	3	MM14669
Pathway	REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY	ADCY2 ADCY6 ADCY8	1.80e-04	14	115	3	M750
Pathway	KEGG_MEDICUS_REFERENCE_EP_NE_ADRB_CAMP_SIGNALING_PATHWAY	ADCY2 ADCY6 ADCY8	2.24e-04	15	115	3	M47794
Pathway	PID_LPA4_PATHWAY	ADCY2 ADCY6 ADCY8	2.24e-04	15	115	3	M56
Pathway	KEGG_MEDICUS_REFERENCE_PTH_PTH1R_PKA_SIGNALING_PATHWAY	ADCY2 ADCY6 ADCY8	2.24e-04	15	115	3	M47504
Pathway	REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	CACNA1C CACNA1D ADCY2 ADCY6 ADCY8 ITPR1	2.52e-04	108	115	6	M17034
Pathway	WP_GPCRS_PEPTIDE	FPR2 BDKRB1 EDNRB LHCGR BRS3	2.63e-04	70	115	5	MM15959
Pathway	KEGG_MEDICUS_REFERENCE_FSHR_GNAS_PKA_SIGNALING_PATHWAY	ADCY2 ADCY6 ADCY8	2.74e-04	16	115	3	M47650
Pathway	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB	ADCY2 ADCY6 ADCY8	2.74e-04	16	115	3	MM14492
Pathway	WP_MAJOR_RECEPTORS_TARGETED_BY_EPINEPHRINE_AND_NOREPINEPHRINE	ADCY2 ADCY6 ADCY8	2.74e-04	16	115	3	M39849
Pathway	WP_GPCRS_ODORANT	GPR137 GPR21 GPR31 BRS3 TAS2R31 TAS2R43 TAS2R50	2.98e-04	157	115	7	MM15872
Pathway	REACTOME_PKA_ACTIVATION_IN_GLUCAGON_SIGNALLING	ADCY2 ADCY6 ADCY8	3.31e-04	17	115	3	M26995
Pathway	KEGG_MEDICUS_REFERENCE_CX3CR1_GNAI_AC_PKA_SIGNALING_PATHWAY	ADCY2 ADCY6 ADCY8	3.31e-04	17	115	3	M47544
Pathway	REACTOME_DAG_AND_IP3_SIGNALING	ADCY2 ADCY6 ADCY8 ITPR1	3.37e-04	41	115	4	M512
Pathway	KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION	CACNA1C CACNA1D ADCY2 ADCY6 ADCY8 ITPR1	3.53e-04	115	115	6	M9387
Pathway	WP_PEPTIDE_GPCRS	FPR2 BDKRB1 EDNRB LHCGR BRS3	3.63e-04	75	115	5	M39696
Pathway	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	FPR2 F2RL2 S1PR1 BDKRB1 EDNRB LHCGR P2RX3 BRS3 HRH4	3.84e-04	272	115	9	M13380
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	CACNA1C CACNA1D ADCY6 ADCY8 ITPR1	4.35e-04	78	115	5	M1921
Pathway	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB	ADCY2 ADCY6 ADCY8	5.45e-04	20	115	3	M759
Pathway	REACTOME_SENSORY_PERCEPTION_OF_TASTE	OTOP1 TAS2R31 TAS2R43 TAS2R50	5.72e-04	47	115	4	M42524
Pathway	REACTOME_SENSORY_PERCEPTION	CACNA1D OR8K1 OR14J1 OR2L13 OR14A16 OR6N1 OR14K1 MYO3A OR4A16 OTOP1 OR10J4 TAS2R31 TAS2R43 TAS2R50	6.62e-04	636	115	14	M41834
Pathway	KEGG_MEDICUS_REFERENCE_GPCR_PLCB_ITPR_SIGNALING_PATHWAY	BDKRB1 EDNRB ITPR1 LHCGR	7.25e-04	50	115	4	M47951
Pathway	KEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1C CACNA1D CACNA1I	8.31e-04	23	115	3	M47666
Pathway	KEGG_DILATED_CARDIOMYOPATHY	CACNA1C CACNA1D ADCY2 ADCY6 ADCY8	8.38e-04	90	115	5	M835
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_GNAS_TO_CRHR_PKA_ACTH_SIGNALING_PATHWAY	ADCY2 ADCY6 ADCY8	9.45e-04	24	115	3	M47520
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1C CACNA1D	9.69e-04	6	115	2	M47762
Pathway	REACTOME_G_PROTEIN_MEDIATED_EVENTS	ADCY2 ADCY6 ADCY8 ITPR1	9.71e-04	54	115	4	M26911
Pathway	REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES	ATP13A4 ATP7B ATP13A5 ATP9A	1.04e-03	55	115	4	M971
Pathway	KEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL	CACNA1C CACNA1D CACNA1I	1.07e-03	25	115	3	M47948
Pathway	REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES	ATP13A4 ATP7B ATP13A5 ATP9A	1.19e-03	57	115	4	MM15643
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_UL33_TO_GNAI_AC_PKA_SIGNALING_PATHWAY	ADCY2 ADCY6 ADCY8	1.20e-03	26	115	3	M47553
Pathway	REACTOME_CA_DEPENDENT_EVENTS	ADCY2 ADCY6 ADCY8	1.20e-03	26	115	3	MM14495
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	CACNA1C CACNA1D ADCY2 ADCY6 ADCY8 ITPR1	1.29e-03	147	115	6	MM15854
Pathway	KEGG_MEDICUS_REFERENCE_CRHR_PKA_ACTH_SIGNALING_PATHWAY	ADCY2 ADCY6 ADCY8	1.34e-03	27	115	3	M47518
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_RASD1_TO_CRHR_PKA_ACTH_SIGNALING_PATHWAY	ADCY2 ADCY6 ADCY8	1.34e-03	27	115	3	M47519
Pathway	REACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS	SLC12A6 SLC12A5	1.35e-03	7	115	2	M27339
Pathway	REACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS	SLC12A6 SLC12A5	1.35e-03	7	115	2	MM15081
Pathway	KEGG_MELANOGENESIS	ADCY2 ADCY6 ADCY8 EDNRB CTNNB1	1.41e-03	101	115	5	M7761
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	CACNA1C CACNA1D ADCY2 ADCY6 ADCY8 ITPR1	1.48e-03	151	115	6	M39329
Pathway	KEGG_MEDICUS_REFERENCE_GHRHR_PKA_GH_SIGNALING_PATHWAY	ADCY2 ADCY6 ADCY8	1.49e-03	28	115	3	M47647
Pathway	REACTOME_ADRENALINE_NORADRENALINE_INHIBITS_INSULIN_SECRETION	CACNA1C CACNA1D ADCY6	1.49e-03	28	115	3	M10679
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	CACNA1C CACNA1D ADCY6 ITPR1	1.53e-03	61	115	4	MM15071
Pathway	KEGG_MEDICUS_REFERENCE_TSH_TG_SIGNALING_PATHWAY	ADCY2 ADCY6 ADCY8	1.66e-03	29	115	3	M47627
Pathway	KEGG_THYROID_CANCER	NTRK1 TFG CTNNB1	1.66e-03	29	115	3	M523
Pathway	PID_ENDOTHELIN_PATHWAY	ADCY2 ADCY6 ADCY8 EDNRB	1.73e-03	63	115	4	M8
Pathway	REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES	SLC12A6 SLC4A8 SLC7A11 SLC12A5 SLC15A1	1.89e-03	108	115	5	M823
Pathway	REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES	SLC12A6 SLC4A8 SLC7A11 SLC12A5 SLC15A1	1.97e-03	109	115	5	MM15074
Pathway	REACTOME_SENSORY_PERCEPTION_OF_TASTE	TAS2R31 TAS2R43 TAS2R50	2.01e-03	31	115	3	MM15691
Pathway	REACTOME_PHASE_0_RAPID_DEPOLARISATION	CACNA1C SCN11A SCN7A	2.21e-03	32	115	3	M27455
Pathway	REACTOME_SERINE_BIOSYNTHESIS	SERINC1 SERINC3	2.29e-03	9	115	2	M27959
Pathway	KEGG_MEDICUS_REFERENCE_COHESIN_LOADING	SMC3 NIPBL	2.29e-03	9	115	2	M47868
Pathway	REACTOME_SERINE_BIOSYNTHESIS	SERINC1 SERINC3	2.29e-03	9	115	2	MM15707
Pathway	BIOCARTA_CELL2CELL_PATHWAY	PECAM1 CTNNB1	2.29e-03	9	115	2	MM1366
Pathway	KEGG_OOCYTE_MEIOSIS	ADCY2 ADCY6 ADCY8 ITPR1 SMC3	2.31e-03	113	115	5	M16817
Pathway	REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS	ADCY2 ADCY6 ADCY8	2.41e-03	33	115	3	MM15058
Pathway	REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION	ADCY2 ADCY6 ADCY8	2.41e-03	33	115	3	M11575
Pathway	REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	CACNA1C CACNA1D ADCY6 ITPR1	2.82e-03	72	115	4	MM14631
Pathway	REACTOME_COHESIN_LOADING_ONTO_CHROMATIN	SMC3 NIPBL	2.84e-03	10	115	2	M27178
Pathway	REACTOME_COHESIN_LOADING_ONTO_CHROMATIN	SMC3 NIPBL	2.84e-03	10	115	2	MM14892
Pathway	KEGG_MEDICUS_REFERENCE_ADRB3_UCP1_SIGNALING_PATHWAY	ADCY2 ADCY6 ADCY8	2.86e-03	35	115	3	M47969
Pathway	WP_ALZHEIMERS_DISEASE	CACNA1C CACNA1D CAPN2 ITPR1	3.12e-03	74	115	4	MM15962
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	ATP13A4 CLCA4 ATP7B ATP13A5 ANO10 ATP9A	3.19e-03	176	115	6	MM15718
Pathway	REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS	TAS2R31 TAS2R43 TAS2R50	3.36e-03	37	115	3	MM15067
Pathway	REACTOME_PLASMA_LIPOPROTEIN_CLEARANCE	NPC1 LSR LIPC	3.36e-03	37	115	3	M27847
Pathway	REACTOME_CA_DEPENDENT_EVENTS	ADCY2 ADCY6 ADCY8	3.36e-03	37	115	3	M749
Pathway	KEGG_MEDICUS_REFERENCE_N_GLYCAN_PRECURSOR_BIOSYNTHESIS_ALG6_TO_OST	ALG10 ALG6	3.46e-03	11	115	2	M47614
Pathway	REACTOME_TRANSPORT_OF_NUCLEOSIDES_AND_FREE_PURINE_AND_PYRIMIDINE_BASES_ACROSS_THE_PLASMA_MEMBRANE	SLC28A2 SLC29A1	3.46e-03	11	115	2	MM15471
Pathway	REACTOME_RIBAVIRIN_ADME	SLC28A2 SLC29A1	3.46e-03	11	115	2	M46429
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	ATP13A4 CLCA4 ATP7B ATP13A5 ANO10 ATP9A	3.86e-03	183	115	6	M997
Pathway	REACTOME_G_PROTEIN_MEDIATED_EVENTS	ADCY2 ADCY6 ADCY8	3.90e-03	39	115	3	MM14496
Pathway	REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS	TAS2R31 TAS2R43 TAS2R50	3.90e-03	39	115	3	M793
Pathway	REACTOME_TRANSPORT_OF_NUCLEOSIDES_AND_FREE_PURINE_AND_PYRIMIDINE_BASES_ACROSS_THE_PLASMA_MEMBRANE	SLC28A2 SLC29A1	4.13e-03	12	115	2	M27728
Pathway	REACTOME_RIBAVIRIN_ADME	SLC28A2 SLC29A1	4.13e-03	12	115	2	MM16638
Pathway	BIOCARTA_CELL2CELL_PATHWAY	PECAM1 CTNNB1	4.13e-03	12	115	2	M12851
Pathway	REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES	SLC35D2 SLC28A2 SLC29A1	4.50e-03	41	115	3	MM15075
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	NPC1 ABCC3 TMED1 MYADM FRAS1 CCPG1 MAN1A1 ARV1 GPX8 TM9SF4 TMEM161B ARFGEF2 ATP9A SLC7A11 MBOAT2 ITPR1 TMTC3 CCT8 PACC1 TMEM164 CTNNB1 DSEL ALG6 SLC29A1	1.19e-09	1201	158	24	35696571
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	NPC1 GPR137 TMED1 CLCA4 ARV1 ANO10 ATP9A MBOAT2 ADCY2 BDKRB1 SLC12A5 SERINC3 SLC29A1 SLC35B1 TMEM234	7.61e-07	697	158	15	28298427
Pubmed	Differential expression of adenylyl cyclase mRNAs in lacrimal glands of NZB/NZW and NOD pre-autoimmune mice.	ADCY2 ADCY6 ADCY8	3.18e-06	7	158	3	12613887
Pubmed	Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.	ADCY2 ADCY6 ADCY8	7.57e-06	9	158	3	9417641
Pubmed	Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.	ADCY2 ADCY6 ADCY8	7.57e-06	9	158	3	12503609
Pubmed	Role of the calcium modulated cyclases in the development of the retinal projections.	ADCY2 ADCY6 ADCY8	7.57e-06	9	158	3	17229090
Pubmed	Blood-Brain Barrier: From Physiology to Disease and Back.	ABCC3 SLC4A8 PECAM1 LSR SLC28A2 SLC29A1	8.88e-06	105	158	6	30280653
Pubmed	Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons.	ADCY2 ADCY6 ADCY8	1.08e-05	10	158	3	11884542
Pubmed	Purification and characterization of a soluble form of mammalian adenylyl cyclase.	ADCY2 ADCY6 ADCY8	1.08e-05	10	158	3	8663304
Pubmed	Comprehensive analysis of the expression patterns of the adenylate cyclase gene family in the developing and adult mouse brain.	ADCY2 ADCY6 ADCY8	1.08e-05	10	158	3	16615126
Pubmed	Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.	MCM8 CHAF1A SLC5A9 BIRC6 SLC5A11 HRH4 HFM1 KCNH5 SLC35B1	1.43e-05	313	158	9	20800603
Pubmed	Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.	ADCY2 ADCY6 ADCY8	1.48e-05	11	158	3	10089566
Pubmed	gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression.	ADCY2 ADCY6 ADCY8	1.48e-05	11	158	3	10808179
Pubmed	Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.	ADCY2 ADCY6 ADCY8	1.48e-05	11	158	3	11299302
Pubmed	The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.	TAS2R31 TAS2R43 TAS2R50	1.96e-05	12	158	3	12379855
Pubmed	HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones.	ADCY2 ADCY6 ADCY8	1.96e-05	12	158	3	10807185
Pubmed	Activated niacin receptor HCA2 inhibits chemoattractant-mediated macrophage migration via Gβγ/PKC/ERK1/2 pathway and heterologous receptor desensitization.	HCAR2 HCAR3	2.05e-05	2	158	2	28186140
Pubmed	The Immunometabolomic Interface Receptor Hydroxycarboxylic Acid Receptor 2 Mediates the Therapeutic Effects of Dimethyl Fumarate in Autoantibody-Induced Skin Inflammation.	HCAR2 HCAR3	2.05e-05	2	158	2	30154797
Pubmed	Bitter Sensing TAS2R50 Mediates the trans-Resveratrol-Induced Anti-inflammatory Effect on Interleukin 6 Release in HGF-1 Cells in Culture.	TAS2R43 TAS2R50	2.05e-05	2	158	2	33461297
Pubmed	Wnt-β-catenin signaling regulates ABCC3 (MRP3) transporter expression in colorectal cancer.	ABCC3 CTNNB1	2.05e-05	2	158	2	27709738
Pubmed	The role of HCA2 (GPR109A) in regulating macrophage function.	HCAR2 HCAR3	2.05e-05	2	158	2	23882124
Pubmed	Crosstalk between microbiome, regulatory T cells and HCA2 orchestrates the inflammatory response in a murine psoriasis model.	HCAR2 HCAR3	2.05e-05	2	158	2	36891315
Pubmed	Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a.	HCAR2 HCAR3	2.05e-05	2	158	2	38007572
Pubmed	PECAM-1 drives β-catenin-mediated EndMT via internalization in colon cancer with diabetes mellitus.	PECAM1 CTNNB1	2.05e-05	2	158	2	37580771
Pubmed	Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate's protective effect in EAE.	HCAR2 HCAR3	2.05e-05	2	158	2	24691444
Pubmed	Isolation and chromosomal localization of GPR31, a human gene encoding a putative G protein-coupled receptor.	GPR31 HCAR3	2.05e-05	2	158	2	9205127
Pubmed	Butyrate ameliorates caerulein-induced acute pancreatitis and associated intestinal injury by tissue-specific mechanisms.	HCAR2 HCAR3	2.05e-05	2	158	2	31347703
Pubmed	Different roles attributed to Cav1 channel subtypes in spontaneous action potential firing and fine tuning of exocytosis in mouse chromaffin cells.	CACNA1C CACNA1D	2.05e-05	2	158	2	21054386
Pubmed	Loss of GPR109A/HCAR2 induces aging-associated hepatic steatosis.	HCAR2 HCAR3	2.05e-05	2	158	2	30659164
Pubmed	Different chromosomal localization of two adenylyl cyclase genes expressed in human brain.	ADCY2 ADCY8	2.05e-05	2	158	2	1427768
Pubmed	Expression and localization of GPR109A (PUMA-G/HM74A) mRNA and protein in mammalian retinal pigment epithelium.	HCAR2 HCAR3	2.05e-05	2	158	2	19223991
Pubmed	Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice.	HCAR2 HCAR3	2.05e-05	2	158	2	23967184
Pubmed	Characterization of a novel cation transporter ATPase gene (ATP13A4) interrupted by 3q25-q29 inversion in an individual with language delay.	ATP13A4 ATP13A5	2.05e-05	2	158	2	15925480
Pubmed	Involvement of the Niacin Receptor GPR109a in the LocalControl of Glucose Uptake in Small Intestine of Type 2Diabetic Mice.	HCAR2 HCAR3	2.05e-05	2	158	2	26371038
Pubmed	Alloreactive T cells deficient of the short-chain fatty acid receptor GPR109A induce less graft-versus-host disease.	HCAR2 HCAR3	2.05e-05	2	158	2	34653248
Pubmed	Phenolic acids suppress adipocyte lipolysis via activation of the nicotinic acid receptor GPR109A (HM74a/PUMA-G).	HCAR2 HCAR3	2.05e-05	2	158	2	19136666
Pubmed	G Protein-Coupled Receptor 109A Maintains the Intestinal Integrity and Protects Against ETEC Mucosal Infection by Promoting IgA Secretion.	HCAR2 HCAR3	2.05e-05	2	158	2	33488584
Pubmed	Lactate-induced activation of HCA2 improves survival in mice with sepsis.	HCAR2 HCAR3	2.05e-05	2	158	2	30951370
Pubmed	An improved targeted cAMP sensor to study the regulation of adenylyl cyclase 8 by Ca2+ entry through voltage-gated channels.	CACNA1C CACNA1D	2.05e-05	2	158	2	24086669
Pubmed	Bitter taste receptors for saccharin and acesulfame K.	TAS2R31 TAS2R43	2.05e-05	2	158	2	15537898
Pubmed	Niacin Ameliorates Hepatic Steatosis by Inhibiting De Novo Lipogenesis Via a GPR109A-Mediated PKC-ERK1/2-AMPK Signaling Pathway in C57BL/6 Mice Fed a High-Fat Diet.	HCAR2 HCAR3	2.05e-05	2	158	2	31858105
Pubmed	Exploring the role of the metabolite-sensing receptor GPR109a in diabetic nephropathy.	HCAR2 HCAR3	2.05e-05	2	158	2	32068460
Pubmed	The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome.	HCAR2 HCAR3	2.05e-05	2	158	2	30657794
Pubmed	Differential zinc permeation and blockade of L-type Ca2+ channel isoforms Cav1.2 and Cav1.3.	CACNA1C CACNA1D	2.05e-05	2	158	2	26049024
Pubmed	Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway.	HCAR2 HCAR3	2.05e-05	2	158	2	34092246
Pubmed	Genetic polymorphisms of L-type calcium channel alpha1C and alpha1D subunit genes are associated with sensitivity to the antihypertensive effects of L-type dihydropyridine calcium-channel blockers.	CACNA1C CACNA1D	2.05e-05	2	158	2	19225208
Pubmed	Ca1.2 and CaV1.3 neuronal L-type calcium channels: differential targeting and signaling to pCREB.	CACNA1C CACNA1D	2.05e-05	2	158	2	16706838
Pubmed	Molecular identification of high and low affinity receptors for nicotinic acid.	HCAR2 HCAR3	2.05e-05	2	158	2	12522134
Pubmed	Temperature-sensitive Cav1.2 calcium channels support intrinsic firing of pyramidal neurons and provide a target for the treatment of febrile seizures.	CACNA1C CACNA1D	2.05e-05	2	158	2	23761887
Pubmed	Non-voltage-gated L-type Ca2+ channels in human T cells: pharmacology and molecular characterization of the major alpha pore-forming and auxiliary beta-subunits.	CACNA1C CACNA1D	2.05e-05	2	158	2	14981074
Pubmed	CaV1.2 and CaV1.3 channel hyperactivation in mouse islet β cells exposed to type 1 diabetic serum.	CACNA1C CACNA1D	2.05e-05	2	158	2	25292336
Pubmed	G Protein-Coupled Receptor 109A and Host Microbiota Modulate Intestinal Epithelial Integrity During Sepsis.	HCAR2 HCAR3	2.05e-05	2	158	2	30271409
Pubmed	Macrophages and stromal cells phagocytose apoptotic bone marrow-derived B lineage cells.	PECAM1 PTPRC	2.05e-05	2	158	2	15067047
Pubmed	Ca(v)1.3 channels produce persistent calcium sparklets, but Ca(v)1.2 channels are responsible for sparklets in mouse arterial smooth muscle.	CACNA1C CACNA1D	2.05e-05	2	158	2	17526649
Pubmed	Niacin fine-tunes energy homeostasis through canonical GPR109A signaling.	HCAR2 HCAR3	2.05e-05	2	158	2	30596513
Pubmed	The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer's disease.	HCAR2 HCAR3	2.05e-05	2	158	2	35320002
Pubmed	Ligand-activated signal transduction in the 2-cell embryo.	CACNA1C CACNA1D	2.05e-05	2	158	2	12606379
Pubmed	GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing.	HCAR2 HCAR3	2.05e-05	2	158	2	16322797
Pubmed	CACNA1I gain-of-function mutations differentially affect channel gating and cause neurodevelopmental disorders.	CACNA1C CACNA1I	2.05e-05	2	158	2	33704440
Pubmed	Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca2+ channel activators.	CACNA1C CACNA1D	2.05e-05	2	158	2	24941892
Pubmed	Nicotinic acid receptor agonists.	HCAR2 HCAR3	2.05e-05	2	158	2	18983141
Pubmed	Gut microbial metabolite butyrate protects against proteinuric kidney disease through epigenetic- and GPR109a-mediated mechanisms.	HCAR2 HCAR3	2.05e-05	2	158	2	31366236
Pubmed	Equal sensitivity of Cav1.2 and Cav1.3 channels to the opposing modulations of PKA and PKG in mouse chromaffin cells.	CACNA1C CACNA1D	2.05e-05	2	158	2	22826131
Pubmed	Transcriptional regulation of L-type calcium channel subtypes Cav1.2 and Cav1.3 by nicotine and their potential role in nicotine sensitization.	CACNA1C CACNA1D	2.05e-05	2	158	2	24470632
Pubmed	GPR109A gene deletion ameliorates gonadectomy-induced bone loss in mice.	HCAR2 HCAR3	2.05e-05	2	158	2	35489706
Pubmed	Correlation between LHCGR and NR5A1 genes polymorphism and male infertility risk.	LHCGR NR5A1	2.05e-05	2	158	2	37827240
Pubmed	Cav1.2 and Cav1.3 L-type calcium channels operate in a similar voltage range but show different coupling to Ca(2+)-dependent conductances in hippocampal neurons.	CACNA1C CACNA1D	2.05e-05	2	158	2	24760982
Pubmed	Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis.	HCAR2 HCAR3	2.05e-05	2	158	2	19561068
Pubmed	Deletion of the L-type calcium channel Ca(V) 1.3 but not Ca(V) 1.2 results in a diminished sAHP in mouse CA1 pyramidal neurons.	CACNA1C CACNA1D	2.05e-05	2	158	2	20014384
Pubmed	Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin.	TAS2R31 TAS2R43	2.05e-05	2	158	2	17702579
Pubmed	The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival.	HCAR2 HCAR3	2.05e-05	2	158	2	24371223
Pubmed	High dietary niacin may increase prostaglandin formation but does not increase tumor formation in ApcMin/+ mice.	HCAR2 HCAR3	2.05e-05	2	158	2	21774590
Pubmed	Role of putative voltage-sensor countercharge D4 in regulating gating properties of CaV1.2 and CaV1.3 calcium channels.	CACNA1C CACNA1D	2.05e-05	2	158	2	30001160
Pubmed	Functional identification of the hematopoietic stem cell niche in the ventral domain of the embryonic dorsal aorta.	PECAM1 PTPRC	2.05e-05	2	158	2	17517650
Pubmed	Rescue and worsening of congenital heart block-associated electrocardiographic abnormalities in two transgenic mice.	CACNA1C CACNA1D	2.05e-05	2	158	2	21352396
Pubmed	GPR109a Regulates Phenotypic and Functional Alterations in Macrophages and the Progression of Type 1 Diabetes.	HCAR2 HCAR3	2.05e-05	2	158	2	36208084
Pubmed	The role of the C-terminus of the human hydroxycarboxylic acid receptors 2 and 3 in G protein activation using Gα-engineered yeast cells.	HCAR2 HCAR3	2.05e-05	2	158	2	26656756
Pubmed	Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.	HCAR2 HCAR3	2.05e-05	2	158	2	37597514
Pubmed	The Role of GPR109a Signaling in Niacin Induced Effects on Fed and Fasted Hepatic Metabolism.	HCAR2 HCAR3	2.05e-05	2	158	2	33924461
Pubmed	A novel gene, FAM11A, associated with the FRAXF CpG island is transcriptionally silent in FRAXF full mutation.	TMEM185B TMEM185A	2.05e-05	2	158	2	12404111
Pubmed	Ketone Body 3-Hydroxybutyrate Ameliorates Atherosclerosis via Receptor Gpr109a-Mediated Calcium Influx.	HCAR2 HCAR3	2.05e-05	2	158	2	33977048
Pubmed	Molecular nature of anomalous L-type calcium channels in mouse cerebellar granule cells.	CACNA1C CACNA1D	2.05e-05	2	158	2	17409250
Pubmed	PUMA-G, an IFN-gamma-inducible gene in macrophages is a novel member of the seven transmembrane spanning receptor superfamily.	HCAR2 HCAR3	2.05e-05	2	158	2	11745392
Pubmed	Neuronal L-type calcium channels open quickly and are inhibited slowly.	CACNA1C CACNA1D	2.05e-05	2	158	2	16267232
Pubmed	Identification of a ubiquitous family of membrane proteins and their expression in mouse brain.	SERINC1 SERINC3	2.05e-05	2	158	2	10637174
Pubmed	Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets.	HCAR2 HCAR3	2.05e-05	2	158	2	25622782
Pubmed	Functional effects of TrkA inhibition on system xC--mediated glutamate release and cancer-induced bone pain.	NTRK1 SLC7A11	2.05e-05	2	158	2	29761734
Pubmed	GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice.	HCAR2 HCAR3	2.05e-05	2	158	2	33420329
Pubmed	The role of L-type voltage-gated calcium channels Cav1.2 and Cav1.3 in normal and pathological brain function.	CACNA1C CACNA1D	2.05e-05	2	158	2	24996399
Pubmed	Molecular identification of nicotinic acid receptor.	HCAR2 HCAR3	2.05e-05	2	158	2	12646212
Pubmed	PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect.	HCAR2 HCAR3	2.05e-05	2	158	2	12563315
Pubmed	Genetic, cellular, and functional evidence for Ca2+ inflow through Cav1.2 and Cav1.3 channels in murine spiral ganglion neurons.	CACNA1C CACNA1D	2.05e-05	2	158	2	24849370
Pubmed	Deficiency of metabolite sensing receptor HCA2 impairs the salutary effect of niacin in hemorrhagic shock.	HCAR2 HCAR3	2.05e-05	2	158	2	30625381
Pubmed	The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain.	NTRK1 TFG	2.05e-05	2	158	2	7565764
Pubmed	Nomenclature of voltage-gated sodium channels.	SCN11A SCN7A	2.05e-05	2	158	2	11144347
Pubmed	Ketones and pain: unexplored role of hydroxyl carboxylic acid receptor type 2 in the pathophysiology of neuropathic pain.	HCAR2 HCAR3	2.05e-05	2	158	2	30085883
Pubmed	Nicotinic acid receptor abnormalities in human skin cancer: implications for a role in epidermal differentiation.	HCAR2 HCAR3	2.05e-05	2	158	2	21655214
Pubmed	(D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G.	HCAR2 HCAR3	2.05e-05	2	158	2	15929991
Pubmed	Divide and conquer: an L-type voltage-gated calcium channel subtype finds a role in conditioned fear.	CACNA1C CACNA1D	2.05e-05	2	158	2	17015854
Pubmed	Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models.	HCAR2 HCAR3	2.05e-05	2	158	2	36991440
Interaction	SLC22A9 interactions	ARV1 GPX8 TM9SF4 TMEM115 LMBR1 ATP9A BIRC6 SERINC1 ALG10 PIGW ALG6 SLC29A1	9.07e-11	120	149	12	int:SLC22A9
Interaction	LPAR1 interactions	GPR137 GPR21 ARV1 TM9SF4 TMEM161B LMBR1 ATP9A ADCY6 SERINC1 ALG10 PIGW TMEM164 ALG6 ADGRL3	5.44e-10	210	149	14	int:LPAR1
Interaction	IPPK interactions	GPR137 ARV1 TMEM161B LMBR1 ATP9A ADCY6 SERINC1 PIGW TMEM164 ADGRL3	1.50e-08	116	149	10	int:IPPK
Interaction	YIPF3 interactions	NPC1 TMEM161B FPR2 LMBR1 ATP9A S1PR1 ADCY6 ALG10 PIGW ADGRL3	1.27e-06	186	149	10	int:YIPF3
Interaction	TTYH1 interactions	SLC12A6 ATP7B TMEM161B TMEM115 LMBR1 ANO10 ADCY6 TMTC3 ALG10 PIGW TMEM164 SLC29A1	2.45e-06	300	149	12	int:TTYH1
Interaction	CLEC2D interactions	ATP7B ARV1 TM9SF4 ARFGEF2 LMBR1 SLC7A11 S1PR1 LSR ADGRL3	1.63e-05	197	149	9	int:CLEC2D
Interaction	CCR6 interactions	TMEM161B LMBR1 ATP9A SERINC1 ALG10 SLC29A1	5.18e-05	89	149	6	int:CCR6
GeneFamily	Olfactory receptors, family 14	OR14J1 OR14A16 OR14K1	8.61e-06	7	115	3	163
GeneFamily	Adenylate cyclases\|Deafness associated genes	ADCY2 ADCY6 ADCY8	2.91e-05	10	115	3	53
GeneFamily	Solute carriers	SLC12A6 SLC4A8 SLC35D2 SLC5A9 SLC7A11 SLC12A5 SLC5A11 SLC15A1 SLC28A2 SLC29A1 SLC35B1	4.39e-05	395	115	11	752
GeneFamily	Hydroxy-carboxylic acid receptors	HCAR2 HCAR3	1.20e-04	3	115	2	200
GeneFamily	Parkinson disease associated genes\|ATPase orphan transporters	ATP13A4 ATP13A5	3.96e-04	5	115	2	1213
GeneFamily	Calcium voltage-gated channel subunits	CACNA1C CACNA1D CACNA1I	5.86e-04	26	115	3	253
GeneFamily	MCM family	MCM8 MCMDC2	1.40e-03	9	115	2	1085
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEAL1 WDFY3	1.40e-03	9	115	2	1230
GeneFamily	Taste 2 receptors	TAS2R31 TAS2R43 TAS2R50	1.94e-03	39	115	3	1162
GeneFamily	Kelch like\|BTB domain containing	KLHL40 KLHL9 KLHL15	2.40e-03	42	115	3	617
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CACNA1C CACNA1D ABCC3 FRAS1 NAALADL2 S1PR1 TMEM132C SBF2 SCN7A	3.56e-08	197	157	9	0034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCell	Influenza_Severe-Neutrophil\|World / Disease group and Cell class	HCAR2 FPR2 CEACAM3 MBOAT2 ADCY6 HCAR3 PLXNC1 WDFY3	1.59e-07	169	157	8	6e8e2580e19c96bcf7fa6a6d8c183df65f428396
ToppCell	COVID-19-kidney-Myeloid\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLC12A6 HCAR2 FPR2 CEACAM3 HCAR3 LIPC PTPRC PLXNC1	4.22e-07	192	157	8	0b9d22a222f1201e375f8e55cace9ef939febae4
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CACNA1C CACNA1D FMO2 OCA2 NAALADL2 ADCY2 S1PR1 SCN7A	4.39e-07	193	157	8	9f69edc97b868d23998abc98928a2e89a885ef8a
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-AT1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	FMO2 TMEM176B CAPN2 TENT5B LSR NSG1 PLD5 DSEL	5.33e-07	198	157	8	5a85c286f79cde5811d2595a3397c6fb7685adee
ToppCell	severe_influenza-Neutrophil\|World / disease group, cell group and cell class (v2)	HCAR2 FPR2 CEACAM3 MBOAT2 HCAR3 PLXNC1 WDFY3	2.87e-06	174	157	7	f9f07436b7d3f190800cd85d229f007032f391e1
ToppCell	CF-Myeloid-Neutrophil\|Myeloid / Disease state, Lineage and Cell class	SLC12A6 HCAR2 FPR2 CEACAM3 HCAR3 LIPC PLXNC1	2.98e-06	175	157	7	8020c3a34f77e68e8149f87481fb1dddd2ac675e
ToppCell	severe-Myeloid-Eosinophils\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CACNA1D NTRK1 S1PR1 SCN7A HRH4 TMEM164 SLC29A1	3.59e-06	180	157	7	ac03812b1409435c55d323a7516deeac82bd3509
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1C CACNA1D FRAS1 FMO2 TMEM132C SCN7A PLD5	3.72e-06	181	157	7	9ede19228ba5c0668a9c06c915510b95585216ef
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM176B MCM8 EDNRB LSR LIPC PLXNC1 TMEM164	4.00e-06	183	157	7	b0b5a41f1a40f9c946d0dc8b67eaccdd9f9b73a5
ToppCell	Influenza-Influenza_Severe-Myeloid-Neutrophil\|Influenza_Severe / Disease, condition lineage and cell class	FPR2 CEACAM3 MBOAT2 HCAR3 PTPRC PLXNC1 WDFY3	4.45e-06	186	157	7	1dfcec9196d4db76fba3abc74e85885b1fb98b87
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B1\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	GPR137 IPO8 TMEM161B LMBR1 S1PR1 ALG10 XPOT	5.12e-06	190	157	7	2434b8ad2976eab7d9147012c28454ab29670709
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	GPR137 IPO8 TMEM161B LMBR1 S1PR1 ALG10 XPOT	5.30e-06	191	157	7	39ef8e1d7cc3ebb11717e8a55501515e3b72b177
ToppCell	droplet-Lung-1m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ABCC3 PECAM1 S1PR1 TSPAN9 EDNRB NSG1 SCN7A	5.49e-06	192	157	7	ff435141329e3e29fa9b08a4d5b2f55074e7f9ab
ToppCell	Control-PLT_5\|World / Disease Group and Platelet Clusters	NBEAL1 ADCY8 SLC15A1 ASB5 SCN7A KCNH5	5.72e-06	126	157	6	4ba753c4e83eb1d41964edfa22135e047f06c481
ToppCell	droplet-Lung-1m-Endothelial-capillary_endothelial-capillary_endothelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TMEM176B PECAM1 S1PR1 TSPAN9 EDNRB NSG1 SCN7A	5.87e-06	194	157	7	e13923860a64ba9cf32df53c9f0cf4e7c321881d
ToppCell	droplet-Lung-1m-Endothelial\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TMEM176B PECAM1 S1PR1 TSPAN9 EDNRB NSG1 SCN7A	5.87e-06	194	157	7	b1a25e3b36e7b7e558ef95ec22a3bdcbceae821f
ToppCell	droplet-Lung-LUNG-1m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PECAM1 MBOAT2 S1PR1 TSPAN9 EDNRB NSG1 SCN7A	5.87e-06	194	157	7	68efc6df31479839a3bd5fe9fbc98ddceecc3b10
ToppCell	droplet-Lung-LUNG-1m-Endothelial-endothelial_cell_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PECAM1 MBOAT2 S1PR1 TSPAN9 EDNRB NSG1 SCN7A	5.87e-06	194	157	7	03985e4ab10f140f758e70dc7bfaa059b4e3bb18
ToppCell	droplet-Lung-1m-Endothelial-capillary_endothelial\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TMEM176B PECAM1 S1PR1 TSPAN9 EDNRB NSG1 SCN7A	5.87e-06	194	157	7	86508dd9b9d345b6624d185048cc92b81dd11c2a
ToppCell	CF-Myeloid\|CF / Disease state, Lineage and Cell class	HCAR2 FPR2 CEACAM3 HCAR3 PTPRC PLXNC1 SBF2	6.07e-06	195	157	7	ecf604de496f389a49429d0bb211e1db6019cc8b
ToppCell	BL-critical-LOC-Myeloid-Neutrophil\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	HCAR2 FPR2 CEACAM3 HCAR3 PTPRC PLXNC1 WDFY3	6.28e-06	196	157	7	f64d7fed31e418c55fe946744d78c3cbecec9bbf
ToppCell	facs-Heart\|facs / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYADM FMO2 PECAM1 S1PR1 SCN7A SERINC3 SLC29A1	6.49e-06	197	157	7	6a9571c0a3238b39214afdece93d7541bc8a0a70
ToppCell	5'-Adult-LargeIntestine-Epithelial-Tuft-related-BEST4+_epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCC3 CLCA4 TMEM176B CEACAM3 OTOP3 TSPAN1 LSR	6.71e-06	198	157	7	efdbac7a3a02bff4ca48841772e0c136556c2b9b
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-AT1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FRAS1 FMO2 TMEM176B CAPN2 TENT5B NSG1 PLD5	6.71e-06	198	157	7	1282db321e27499d310339d6383974614e295a20
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-2_Progenitor-Progenitor_AT1-AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	FMO2 TMEM176B TENT5B LSR NSG1 PLD5 DSEL	6.71e-06	198	157	7	8d9858dcb21f20d0c040b22a2cae543eaebd54bc
ToppCell	Tracheal-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1C EDNRB ITPR1 LHCGR ABCG4 ASB5 HFM1	6.71e-06	198	157	7	1e1ea54f0c234f3b6d29064c4881d8a0c0949a75
ToppCell	severe-Neutrophil\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	HCAR2 FPR2 CEACAM3 MBOAT2 HCAR3 PLXNC1 WDFY3	7.16e-06	200	157	7	f04d5951bac4dee47c22aaf7973312ca797f322e
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	HCAR2 CEACAM3 MBOAT2 ADCY8 HCAR3 HRH4	1.00e-05	139	157	6	fa0eedebf53317928022c3bed391ce99a2114f98
ToppCell	facs-Lung-nan-3m-Myeloid-Intermediate_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR31 LAIR1 SLC7A11 SLC5A11 PTPRC ASB5	1.94e-05	156	157	6	3f0b9e35d4da85c90759b930052e5b9c3cde9b15
ToppCell	facs-Lung-nan-3m-Myeloid-intermediate_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR31 LAIR1 SLC7A11 SLC5A11 PTPRC ASB5	1.94e-05	156	157	6	69e6e8810d1738a66c9821910f41498931cf30cc
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 ATP13A5 C2orf74 ADCY2 ADCY8 PLD5	2.23e-05	160	157	6	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 ATP13A5 C2orf74 ADCY2 ADCY8 PLD5	2.23e-05	160	157	6	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	E16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MAN1A1 ATP7B MCMDC2 TSPAN1 SLC15A1 TMEM164	2.40e-05	162	157	6	8e0f03fcc25b2ea777e8478fbf771699cf93719c
ToppCell	E16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MAN1A1 ATP7B MCMDC2 TSPAN1 SLC15A1 TMEM164	2.40e-05	162	157	6	e0417f1242edf71934fe62bccc55c4678f7ff4ac
ToppCell	367C-Fibroblasts-Fibroblast-G-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ABCC3 FMO2 SLC4A8 KCNC3 ADGRG2	2.41e-05	97	157	5	a1279377bf0ee5662db8b9303f5f1fd418dee6df
ToppCell	367C-Fibroblasts-Fibroblast-G\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ABCC3 FMO2 SLC4A8 KCNC3 ADGRG2	2.41e-05	97	157	5	12cbd03b33e76e5e471bbee2a9c11f27e8b21123
ToppCell	remission-HSPC\|World / disease stage, cell group and cell class	ATP13A4 ATP7B NTRK1 SLC12A5 TAS2R31 HACD1	2.75e-05	166	157	6	d269ee6f7adb55b05dcb5eaea96629ccb0b2d6e3
ToppCell	facs-Trachea-nan-18m-Myeloid-granulocyte\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HCAR2 SCN11A FPR2 SLC7A11 PTPRC HRH4	2.75e-05	166	157	6	7f8b4cf63c3e292ae421f111edaa4572717f4db1
ToppCell	droplet-Lung-LUNG-30m-Myeloid-dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC4A8 MCM8 GPR31 ADCY6 PLXNC1 PLD5	2.94e-05	168	157	6	0e8b0e6399c6c82c9c0e546f7316f902de0765d3
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PECAM1 S1PR1 EDNRB SCN7A SERINC3 HFM1	3.04e-05	169	157	6	41ad349806b279fbe1374b7e3cc7f146a11adb44
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PECAM1 S1PR1 EDNRB SCN7A SERINC3 HFM1	3.04e-05	169	157	6	42782c61592742190ab0cba8a94f8bdf9c278f90
ToppCell	severe-Myeloid-Eosinophils\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CACNA1D NTRK1 SCN7A HRH4 TMEM164 SLC29A1	3.14e-05	170	157	6	863f0266d5837cdbc3e09a3fe6a99dd3e6261674
ToppCell	CTRL-Myeloid-Neutrophil\|Myeloid / Disease state, Lineage and Cell class	HCAR2 FPR2 CEACAM3 MBOAT2 HCAR3 PLXNC1	3.14e-05	170	157	6	151dabe1d240dde414c881bf4fa816c69fa1c32d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic-Neutrophil\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HCAR2 FPR2 CEACAM3 HCAR3 PTPRC PLXNC1	3.24e-05	171	157	6	ef9397cec7f5c217d34583f26270af7ed7fbcebf
ToppCell	3'-Adult-Distal_Rectal-Epithelial-Tuft-related-BEST4+_epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HCAR2 CLCA4 CEACAM3 OTOP3 SLC7A11 TSPAN1	3.24e-05	171	157	6	317b70d72a4ca5336cfb6a49dc57f8e2a8a1c736
ToppCell	AT1-AT2_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	ABCC3 KLHL40 ADCY6 TSPAN1 FSIP2 LSR	3.35e-05	172	157	6	0be41df5d35d818deb7316ac21c9366eb4b7bfd1
ToppCell	CTRL-Myeloid-Neutrophil\|CTRL / Disease state, Lineage and Cell class	HCAR2 FPR2 CEACAM3 HCAR3 PTPRC PLXNC1	3.35e-05	172	157	6	ef3a6fe3b7300959f9f71130200c7fb8741c42b0
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADCY8 TSPAN9 TMEM132C SCN7A OPN5 PLD5	4.19e-05	179	157	6	d1365d48d1b017a7917f4f63a82ac4720c3d87df
ToppCell	10x5'v1-week_17-19-Myeloid_neutrophil-granulo-eo/baso/mast-eosinophil\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	HCAR2 SLC35D2 ATP9A SLC12A5 HCAR3 TMEM164	4.19e-05	179	157	6	d16dc58b5b22762a5a3c875563ced18022d08908
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil-Neu_c2-CXCR4(low)\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	SLC12A5 HCAR3 P2RX3 ADGRL3	4.55e-05	56	157	4	f535a4d6d487f186152124704e6922fc0e575847
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ATP13A4 FMO2 TMEM176B TENT5B NSG1 PLD5	4.74e-05	183	157	6	274483009b309289e4cb84beedf6806430db6ff6
ToppCell	CF-Myeloid-Neutrophil\|CF / Disease state, Lineage and Cell class	HCAR2 FPR2 CEACAM3 HCAR3 LIPC PLXNC1	4.74e-05	183	157	6	da43827952e6fdee2ce94648c316182f272b321c
ToppCell	COVID_non-vent-Myeloid-Monocytic-Neutrophil\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	HCAR2 FPR2 CEACAM3 MBOAT2 PLXNC1 WDFY3	5.03e-05	185	157	6	2c89af7cdf5306b900a5b8ec4fdfb8210e5667ed
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	NPC1 TMEM161B BIRC6 SLC7A11 PTPRC KLHL15	5.03e-05	185	157	6	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	5'-Adult-Distal_Rectal-Epithelial-Tuft-related\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCC3 TMEM176B CEACAM3 MBOAT2 TSPAN1 LSR	5.19e-05	186	157	6	4046b701aa29712d9f7c774f8955215122c3c003
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ATP13A4 FRAS1 FMO2 NAALADL2 MYO3A PLD5	5.19e-05	186	157	6	4e94158db52df41d71e67b02b9895a358eebee0f
ToppCell	P28-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell_of_alveolus\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ABCC3 PECAM1 S1PR1 EDNRB SCN7A SERINC3	5.19e-05	186	157	6	375642f353842184792a834361284d6897c728de
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	NPC1 TMEM161B BIRC6 SLC7A11 PTPRC KLHL15	5.19e-05	186	157	6	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	5'-Adult-Distal_Rectal-Epithelial-Tuft-related-BEST4+_epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCC3 TMEM176B CEACAM3 MBOAT2 TSPAN1 LSR	5.19e-05	186	157	6	bd5837033c1ffcbe5dd30195cc4846a2ba351bcd
ToppCell	ILEUM-inflamed-(8)_Fibroblast-(8)_Smooth_muscle_cells\|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	F2RL2 BDKRB1 EDNRB NSG1 SCN7A ADGRL3	5.19e-05	186	157	6	cacc2f0b2ed46516173b61ba1c5c226a2db7cddc
ToppCell	facs-Aorta-Heart-3m-Endothelial-nan\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PECAM1 S1PR1 TSPAN9 EDNRB SERINC3 CTNNB1	5.34e-05	187	157	6	df0279b7e94e26f5541b0e2a0ce56befa96ec8ca
ToppCell	facs-Heart-LV-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYADM PECAM1 S1PR1 EDNRB SLC28A2 SERINC3	5.34e-05	187	157	6	1bc338c22d645a854f8d8eb8a064c441121fb673
ToppCell	droplet-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ABCC3 PECAM1 S1PR1 EDNRB SLC12A5 NSG1	5.50e-05	188	157	6	db0652f000d459493321b53239326706eace598c
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC12A5 ITPR1 KCNC3 NSG1 ST8SIA5 PLD5	5.50e-05	188	157	6	1efbc99bcd6542e5d9fa91edb7c4295167914786
ToppCell	10x5'v1-week_12-13-Myeloid_neutrophil-granulo-eo/baso/mast-basophil\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	MYADM HCAR2 NTRK1 HCAR3 HRH4 TMEM164	5.50e-05	188	157	6	b4d695c373195d389e0a579e9589e87433286b24
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADCY8 TSPAN9 TMEM132C SCN7A OPN5 PLD5	5.50e-05	188	157	6	8de5a07301f9b5984680c873e5a92395b5ed3dd3
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1D FRAS1 FMO2 S1PR1 TMEM132C SCN7A	5.67e-05	189	157	6	203c80030df08ae112f9ae4043709f455d87ce89
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_granulocytic-neutrophil\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	HCAR2 FPR2 CEACAM3 MBOAT2 HCAR3 WDFY3	5.67e-05	189	157	6	235c24eeab5139f5821fccd5c879d8787682f4ef
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial-endothelial_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PECAM1 S1PR1 TSPAN9 EDNRB SLC28A2 SERINC3	5.83e-05	190	157	6	38a815abf0ac5cac6071737cadc54a514f62d37d
ToppCell	droplet-Heart-4Chambers-18m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM176B PECAM1 SLC5A9 EDNRB LSR PLXNC1	5.83e-05	190	157	6	6f71a9f74af7cd9a674753cfc9833ebe5bba0fa2
ToppCell	PCW_13-14\|World / Celltypes from embryonic and fetal-stage human lung	CACNA1D ABCC3 FMO2 NAALADL2 S1PR1 TMEM132C	5.83e-05	190	157	6	62a3ec1ae0829602b0569cc051210551644f1d46
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PECAM1 S1PR1 TSPAN9 EDNRB SLC28A2 SERINC3	5.83e-05	190	157	6	bb1476b44dd49e1dd52a636a91c4600b6d4fbe2e
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PECAM1 S1PR1 TSPAN9 EDNRB SLC28A2 SERINC3	5.83e-05	190	157	6	d180205c70b5ca9bc5a01a2e6cb42fcebc7f630d
ToppCell	PND01-Endothelial\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PECAM1 S1PR1 EDNRB NSG1 SCN7A SERINC3	6.01e-05	191	157	6	96b9b0aaf0cb2d6f929ff563dbaedc83ffb4795e
ToppCell	RV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	FMO2 MAN1A1 EDNRB TMEM132C SCN7A ADGRL3	6.01e-05	191	157	6	70c067c54084bfb02c29bab085f4defd477194fb
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TMEM176B PECAM1 S1PR1 EDNRB SCN7A SERINC3	6.18e-05	192	157	6	53d438e35c14e7656585942b788459e6d843c555
ToppCell	NS-critical-d_0-4-Myeloid-Neutrophil\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	HCAR2 FPR2 CEACAM3 HCAR3 PTPRC PLXNC1	6.18e-05	192	157	6	3db74359c30172a51177e00eac1f48f483e15578
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TMEM176B PECAM1 S1PR1 EDNRB SCN7A SERINC3	6.18e-05	192	157	6	9a1aeac3ecf31f865a23d8ee15a82aef31779089
ToppCell	PND01-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PECAM1 S1PR1 EDNRB NSG1 SCN7A SERINC3	6.36e-05	193	157	6	b6b065b0c2ad31d1488dfa970450b29a8ac1f3aa
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	NBEAL1 LMBR1 ATP9A BIRC6 SBF2 WDFY3	6.36e-05	193	157	6	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	Control-Fibroblasts-Vascular_smooth_muscle\|Control / group, cell type (main and fine annotations)	CACNA1C FMO2 PECAM1 S1PR1 SCN7A ADGRL3	6.36e-05	193	157	6	60e44aac8be0430ad35e20eb98b1b700d76a0427
ToppCell	PND01-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PECAM1 S1PR1 EDNRB NSG1 SCN7A SERINC3	6.36e-05	193	157	6	4513e6cb3f86d9cc56e7892fbe11a861335bd179
ToppCell	PCW_13-14-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_monocyte_(14)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	HCAR2 FPR2 CEACAM3 LAIR1 HCAR3 PTPRC	6.36e-05	193	157	6	b044fca95f519ff2ceb378afe40a95911931a29e
ToppCell	PND01-Endothelial-Endothelial_blood-vessel-Microvascular_EC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PECAM1 S1PR1 EDNRB NSG1 SCN7A SERINC3	6.36e-05	193	157	6	30254658a2023ea9808cdd786530b966a1446418
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADCY8 TSPAN9 TMEM132C SCN7A OPN5 PLD5	6.36e-05	193	157	6	c4b22b62f3cc7bf0ec0eba76e1504c236290bbc9
ToppCell	Mesenchymal-matrix_fibroblast_1_cell\|World / Lineage, Cell type, age group and donor	CACNA1C CACNA1D FRAS1 FMO2 TMEM132C SCN7A	6.36e-05	193	157	6	acad568621ed677031797b8c2e34dafea798d681
ToppCell	severe-Myeloid-CD16_Monocytes\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	ABCC3 TMEM176B PECAM1 KCNC3 WDR11 SLC29A1	6.55e-05	194	157	6	1b33248b8a7cb914783bcf9e6a80481b4db7e0e8
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1C CACNA1D FMO2 ADCY2 TMEM132C SCN7A	6.55e-05	194	157	6	011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Mesenchymal-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO2 GPX8 NTRK1 NSG1 SCN7A SLC29A1	6.55e-05	194	157	6	da926441053b499cb5107ccb116fb1b3844d82b7
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Mesenchymal\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO2 GPX8 NTRK1 NSG1 SCN7A SLC29A1	6.55e-05	194	157	6	54a7f693966b5c02f6b248950ddb5fa32af3ae67
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO2 GPX8 NTRK1 NSG1 SCN7A SLC29A1	6.55e-05	194	157	6	f34b3bbdebf56f66ff499e390e5515a4a4093f90
ToppCell	droplet-Lung-LUNG-1m-Endothelial-Capillary_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PECAM1 MBOAT2 S1PR1 TSPAN9 NSG1 SCN7A	6.55e-05	194	157	6	f6c9cc362ccdbc7e790f7c8d1c56cab3557c5306
ToppCell	COVID-19-Fibroblasts-Alveolar_FB\|COVID-19 / group, cell type (main and fine annotations)	CACNA1C CACNA1D FRAS1 FMO2 SCN7A ADGRL3	6.74e-05	195	157	6	603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCell	moderate-Myeloid\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	HCAR2 TMEM176B FPR2 HCAR3 PTPRC PLXNC1	6.93e-05	196	157	6	76a4c615ea7594e99c1a938d6900a1b262cc09f5
ToppCell	NS-moderate-d_16-33-Myeloid\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	HCAR2 TMEM176B FPR2 HCAR3 PTPRC PLXNC1	6.93e-05	196	157	6	dc8483625f1188771eb98bd94757b25163b2fc2f
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ATP13A4 FMO2 NAALADL2 MYO3A PLD5 DSEL	7.13e-05	197	157	6	b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCell	facs-Trachea-3m\|Trachea / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYADM CCPG1 CAPN2 SERINC1 SERINC3 CTNNB1	7.13e-05	197	157	6	e77016d64b1cac9825fec7cfe5071f1567401187
ToppCell	facs-Trachea-nan-3m\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYADM CCPG1 CAPN2 SERINC1 SERINC3 CTNNB1	7.13e-05	197	157	6	0353d925ee4b7aefc2c51b5fab873f465cdf9ebc
ToppCell	facs-Heart-RV-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYADM CAPN2 SERINC1 SLC28A2 SERINC3 CTNNB1	7.13e-05	197	157	6	a2d9d3098e5103290b434919dbbc40d7e79fcae0
Drug	verapamil	CACNA1C CACNA1D ABCC3 HCAR2 BIRC6 ADCY2 ADCY6 ADCY8 ITPR1 ABCG4 HCAR3 MYO3A KCNC3 SCN7A CACNA1I KCNH5	2.78e-07	490	156	16	CID000002520
Drug	myo-inositol	CACNA1C CACNA1D FPR2 ADCY2 S1PR1 BDKRB1 ADCY6 ADCY8 EDNRB ITPR1 SLC5A11 LHCGR PTPRC P2RX3 BRS3 ALG10 PIGW HRH4 CACNA1I DSEL	7.52e-07	811	156	20	CID000000892
Drug	sodium	SLC12A6 CACNA1C CACNA1D ABCC3 HCAR2 SLC4A8 ATP7B SLC7A11 ADCY2 ADCY6 ADCY8 SLC12A5 SLC5A11 HCAR3 P2RX3 SLC15A1 SCN7A SLC28A2 SLC29A1 PHTF1 KCNH5	2.02e-06	944	156	21	CID000000923
Drug	TMB-8	CACNA1C CACNA1D ADCY2 ADCY6 ADCY8 ITPR1 LSR OTOP1 CACNA1I	3.62e-06	176	156	9	CID000005494
Drug	otenzepad	HCAR2 NUMA1 ADCY2 ADCY6 ADCY8 HCAR3	3.82e-06	61	156	6	CID000107867
Drug	lanthanum	CACNA1C CACNA1D ADCY2 ADCY6 ADCY8 ITPR1 PKD2L2 CACNA1I	4.55e-06	136	156	8	CID000023926
Drug	lercanidipine	CACNA1C CACNA1D TFG BDKRB1 ITPR1 CACNA1I	4.62e-06	63	156	6	CID000065866
Drug	NSC7524	CACNA1C CACNA1D HCAR2 ADCY6 ADCY8 ITPR1 HCAR3 SCN7A CACNA1I	4.76e-06	182	156	9	CID000005657
Drug	AC1L1TJF	CACNA1C CACNA1D ADCY2 ADCY6 ADCY8 CACNA1I	6.08e-06	66	156	6	CID000003377
Drug	gallopamil	CACNA1C CACNA1D BIRC6 ITPR1 LSR CACNA1I	6.64e-06	67	156	6	CID000001234
Drug	nicardipine	CACNA1C CACNA1D HCAR2 BDKRB1 EDNRB ITPR1 HCAR3 CACNA1I	7.31e-06	145	156	8	CID000004473
Drug	potassium	SLC12A6 CACNA1C CACNA1D HCAR2 CLCA4 SLC7A11 ADCY2 ADCY6 ADCY8 SLC12A5 ITPR1 SLC5A11 HCAR3 P2RX3 KCNC3 ALG10 SCN7A HRH4 CACNA1I KCNH5	1.93e-05	1008	156	20	CID000000813
Drug	2',3'-dideoxyadenosine	PKDREJ ADCY2 ADCY6 ADCY8 SLC28A2 SLC29A1	2.14e-05	82	156	6	CID000020039
Drug	Cinnarizine	CACNA1C CACNA1D CACNA1I	2.57e-05	9	156	3	DB00568
Drug	Substance P	HCAR2 NTRK1 ADCY2 BDKRB1 ADCY6 ADCY8 EDNRB HCAR3 P2RX3 BRS3 HRH4	2.58e-05	343	156	11	CID000036511
Drug	brimonidine	HCAR2 ADCY2 ADCY6 ADCY8 HCAR3 HRH4	2.81e-05	86	156	6	CID000002435
Drug	AC1L63MU	HCAR2 FPR2 ADCY2 BDKRB1 ADCY6 ADCY8 EDNRB LHCGR HCAR3 HRH4 CTNNB1	2.86e-05	347	156	11	CID000285703
Drug	saccharin	ADCY2 ADCY6 ADCY8 TAS2R31 TAS2R43	3.42e-05	54	156	5	CID000005143
Drug	2',5'-dd3'-FSBA	ADCY2 ADCY6 ADCY8	3.66e-05	10	156	3	CID003081206
Drug	NC-5Z	ADCY2 ADCY6 ADCY8	3.66e-05	10	156	3	CID003035914
Drug	tetrahydrofurfuryl alcohol	ADCY2 ADCY6 ADCY8 HRH4	3.82e-05	28	156	4	CID000007360
Drug	D-myo-inositol-1,4,5-triphosphate	CACNA1C CACNA1D NTRK1 FPR2 ADCY2 BDKRB1 ADCY6 ADCY8 EDNRB ITPR1 BRS3 HRH4 CACNA1I XPOT	3.82e-05	568	156	14	CID000000806
Drug	tolazoline	ADCY2 ADCY6 ADCY8 HRH4	4.41e-05	29	156	4	CID000005504
Drug	propranolol	CACNA1C CACNA1D HCAR2 BIRC6 ADCY2 BDKRB1 ADCY6 ADCY8 ITPR1 HCAR3 HRH4 CACNA1I	4.69e-05	434	156	12	CID000004946
Drug	AC1L40QM	ADCY2 ADCY6 ADCY8	5.00e-05	11	156	3	CID000099213
Drug	B-Mlvp	ADCY2 ADCY6 ADCY8	5.00e-05	11	156	3	CID000195648
Drug	Mibefradil	CACNA1C CACNA1D CACNA1I	5.00e-05	11	156	3	DB01388
Drug	AC1NY9KD	ADCY2 ADCY6 ADCY8	5.00e-05	11	156	3	CID005771741
Drug	NSC759576	CACNA1C CACNA1D BIRC6 ADCY2 ADCY6 ADCY8 ITPR1 CACNA1I	5.33e-05	191	156	8	CID000003075
Drug	8-bromoguanosine 3',5'-cyclic monophosphate	SLC12A6 CACNA1C CACNA1D NUMA1 ADCY6 ADCY8 SLC12A5 ITPR1 KCNC3 CACNA1I	5.46e-05	308	156	10	CID000001915
Drug	nitrendipine	CACNA1C CACNA1D ADCY8 ITPR1 BRS3 CACNA1I	5.88e-05	98	156	6	CID000004507
Drug	glibenclamide	CACNA1C CACNA1D ABCC3 CLCA4 ATP7B TMEM176B ADCY6 ADCY8 EDNRB ABCG4 LIPC	6.82e-05	382	156	11	CID000003488
Drug	Isradipine [75695-93-1]; Up 200; 10.8uM; MCF7; HT_HG-U133A	IPO8 SLC7A11 BDKRB1 EDNRB TSPAN1 ITPR1 KCNC3 WDFY3	6.87e-05	198	156	8	6508_UP
Drug	CNS 1145	CACNA1C CACNA1D ITPR1 CACNA1I	7.43e-05	33	156	4	CID000190902
Drug	IHC-64	CACNA1C CACNA1D ITPR1 CACNA1I	7.43e-05	33	156	4	CID000162753
Drug	FCE 23884	ADCY2 ADCY6 ADCY8	8.58e-05	13	156	3	CID000065898
Drug	procaine	CACNA1C CACNA1D HCAR2 ITPR1 HCAR3 SCN7A CACNA1I	9.10e-05	153	156	7	CID000004914
Drug	pyraclofos	CACNA1C CACNA1D KCNC3 SCN7A CACNA1I KCNH5	9.12e-05	106	156	6	CID000093460
Drug	Verteporfin [129497-78-5]; Down 200; 2.8uM; MCF7; HT_HG-U133A	NPC1 ABCC3 MAN1A1 TM9SF4 NUMA1 MBOAT2 SERINC1	9.87e-05	155	156	7	6817_DN
Drug	oxotremorine	HCAR2 CLCA4 ADCY2 ADCY6 ADCY8 HCAR3	1.01e-04	108	156	6	CID000004630
Drug	AC1NSKJI	HCAR2 BIRC6 ADCY6 ADCY8 HCAR3	1.04e-04	68	156	5	CID005311391
Drug	AC1L1KS5	CACNA1C CACNA1D FPR2 BDKRB1 ADCY6 ADCY8 EDNRB ITPR1 BRS3 CACNA1I	1.07e-04	334	156	10	CID000005631
Drug	AC1L1XPX	ADCY2 ADCY6 ADCY8 CTNNB1	1.31e-04	38	156	4	CID000011606
Drug	BMY 42393	ADCY2 ADCY6 ADCY8	1.35e-04	15	156	3	CID000131961
Drug	caffeine	CACNA1C CACNA1D HCAR2 ADCY2 ADCY6 ADCY8 PPP4R3A ITPR1 HCAR3 LSR PKD2L2 P2RX3 CACNA1I	1.37e-04	562	156	13	CID000002519
Drug	CAS 298-57-7	CACNA1C CACNA1D ITPR1 HRH4 CACNA1I	1.46e-04	73	156	5	CID000002761
Disease	epilepsy (implicated_via_orthology)	SLC12A6 SCN11A BDKRB1 SLC12A5 TMTC3 SBF2 SCN7A KCNH5	1.70e-06	163	147	8	DOID:1826 (implicated_via_orthology)
Disease	46,XY Sex Reversal 3	LHCGR NR5A1	7.37e-05	3	147	2	C3489793
Disease	hepatitis (implicated_via_orthology)	ATP7B LIPC	7.37e-05	3	147	2	DOID:2237 (implicated_via_orthology)
Disease	46, XY Disorders of Sex Development	LHCGR NR5A1	7.37e-05	3	147	2	C2751824
Disease	Male Pseudohermaphroditism	LHCGR NR5A1	7.37e-05	3	147	2	C0238395
Disease	Timothy syndrome (implicated_via_orthology)	CACNA1C CACNA1D	1.47e-04	4	147	2	DOID:0060173 (implicated_via_orthology)
Disease	juvenile-onset Parkinson's disease (implicated_via_orthology)	ATP13A4 ATP13A5	1.47e-04	4	147	2	DOID:0060893 (implicated_via_orthology)
Disease	Kufor-Rakeb syndrome (implicated_via_orthology)	ATP13A4 ATP13A5	1.47e-04	4	147	2	DOID:0060556 (implicated_via_orthology)
Disease	Ovarian Failure, Premature	MCM8 HFM1 NR5A1	1.51e-04	21	147	3	C0085215
Disease	hereditary sensory neuropathy (implicated_via_orthology)	SCN11A NTRK1	2.44e-04	5	147	2	DOID:0050548 (implicated_via_orthology)
Disease	Congenital muscular hypertrophy-cerebral syndrome	SMC3 NIPBL	2.44e-04	5	147	2	C1802395
Disease	Cornelia de Lange Syndrome 3	SMC3 NIPBL	2.44e-04	5	147	2	C1853099
Disease	Cornelia de Lange Syndrome 1	SMC3 NIPBL	2.44e-04	5	147	2	C4551851
Disease	De Lange syndrome	SMC3 NIPBL	3.65e-04	6	147	2	cv:C0270972
Disease	Cornelia de Lange syndrome (implicated_via_orthology)	SMC3 NIPBL	3.65e-04	6	147	2	DOID:11725 (implicated_via_orthology)
Disease	Manic Disorder	CACNA1C CACNA1D NTRK1 ADCY2	4.43e-04	71	147	4	C0024713
Disease	Congenital Pain Insensitivity	SCN11A NTRK1	5.09e-04	7	147	2	C0002768
Disease	Hereditary Sensory Autonomic Neuropathy, Type 5	SCN11A NTRK1	5.09e-04	7	147	2	C0020075
Disease	Periventricular Nodular Heterotopia	ARFGEF2 TMTC3	5.09e-04	7	147	2	C1868720
Disease	Manic	CACNA1C CACNA1D NTRK1 ADCY2	6.34e-04	78	147	4	C0338831
Disease	Depression, Bipolar	CACNA1C CACNA1D NTRK1 ADCY2	6.65e-04	79	147	4	C0005587
Disease	Bipolar Disorder	SLC12A6 CACNA1C CACNA1D NTRK1 ADCY2 S1PR1 ADCY8 ITPR1 HCAR3	6.74e-04	477	147	9	C0005586
Disease	neuroblastoma (is_marker_for)	NTRK1 CHAF1A	6.77e-04	8	147	2	DOID:769 (is_marker_for)
Disease	Cornelia De Lange Syndrome	SMC3 NIPBL	6.77e-04	8	147	2	C0270972
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	CACNA1C CACNA1D CAPN2	7.67e-04	36	147	3	DOID:11723 (implicated_via_orthology)
Disease	Allodynia	SCN11A BDKRB1 SLC12A5 P2RX3	8.38e-04	84	147	4	C0458247
Disease	Mechanical Allodynia	SCN11A BDKRB1 SLC12A5 P2RX3	8.38e-04	84	147	4	C2936719
Disease	Hyperalgesia, Secondary	SCN11A BDKRB1 SLC12A5 P2RX3	8.38e-04	84	147	4	C0751212
Disease	Hyperalgesia, Primary	SCN11A BDKRB1 SLC12A5 P2RX3	8.38e-04	84	147	4	C0751211
Disease	Hyperalgesia, Thermal	SCN11A BDKRB1 SLC12A5 P2RX3	8.38e-04	84	147	4	C0751214
Disease	Tactile Allodynia	SCN11A BDKRB1 SLC12A5 P2RX3	8.38e-04	84	147	4	C0751213
Disease	Hyperalgesia	SCN11A BDKRB1 SLC12A5 P2RX3	8.38e-04	84	147	4	C0020429
Disease	Inherited neuropathies	NTRK1 ITPR1 KCNC3	1.05e-03	40	147	3	C0598589
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN11A SCN7A	1.08e-03	10	147	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN11A SCN7A	1.08e-03	10	147	2	DOID:0080422 (implicated_via_orthology)
Disease	1-palmitoyl-2-oleoyl-GPE (16:0/18:1) measurement	PAQR9 LIPC	1.08e-03	10	147	2	EFO_0800608
Disease	neuroblastoma (is_implicated_in)	CHAF1A PECAM1	1.08e-03	10	147	2	DOID:769 (is_implicated_in)
Disease	Neurodevelopmental Disorders	ITPR1 SMC3 WDFY3 CTNNB1	1.22e-03	93	147	4	C1535926
Disease	hereditary spastic paraplegia (implicated_via_orthology)	ATP13A4 CAPN2 ATP13A5	1.29e-03	43	147	3	DOID:2476 (implicated_via_orthology)
Disease	1-stearoyl-2-oleoyl-GPE (18:0/18:1) measurement	PAQR9 LIPC	1.32e-03	11	147	2	EFO_0800269
Disease	Methionine sulfoxide measurement	FMO2 TMEM132C	1.57e-03	12	147	2	EFO_0021650
Disease	niacinamide measurement	FMO2 NAALADL2	1.57e-03	12	147	2	EFO_0010511
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN11A SCN7A	1.57e-03	12	147	2	DOID:0060170 (implicated_via_orthology)
Disease	neuronal ceroid lipofuscinosis (implicated_via_orthology)	ATP13A4 ATP13A5	2.16e-03	14	147	2	DOID:14503 (implicated_via_orthology)
Disease	cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	HCAR2 BIRC6 HCAR3 LIPC SBF2 HFM1	2.67e-03	276	147	6	EFO_0004612, EFO_0020943
Disease	vascular endothelial growth factor measurement	ATP13A4 ATP13A5 KCNC3	2.77e-03	56	147	3	EFO_0004762
Disease	level of Sphingomyelin (d32:1) in blood serum	LIPC KCNH5	3.19e-03	17	147	2	OBA_2045173
Disease	free cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	HCAR2 SLC4A8 BIRC6 HCAR3 LIPC SBF2	4.22e-03	303	147	6	EFO_0004612, EFO_0020945
Disease	diet measurement, body mass index	ATP13A4 ATP13A5	4.42e-03	20	147	2	EFO_0004340, EFO_0008111
Disease	obesity (implicated_via_orthology)	CAPN2 ITPR1 LIPC SLC15A1 CTNNB1	4.54e-03	215	147	5	DOID:9970 (implicated_via_orthology)
Disease	macrophage inflammatory protein 1b measurement	CLCA4 TMEM115 ANO10 TMEM132E	4.85e-03	136	147	4	EFO_0008219

Protein segments in the cluster

Peptide	Gene	Start	Entry
VFKSNLVCAFIVLLF	ADCY8	711	P40145
LVCAFIVLLFITAIQ	ADCY8	716	P40145
LTQFCILFKRTFLSI	ABCG4	371	Q9H172
VIKANLFISIFLVVA	BDKRB1	116	P46663
LILVVALTQFCVAFF	ATP13A5	1116	Q4VNC0
ERCISVVQKLVLFLL	BIRC6	2326	Q9NR09
LVKLACIVVASFVLC	ALG6	231	Q9Y672
ALLVFCFICFIQLLI	ADCY6	676	O43306
LIIQLGVCLFILFAD	ATP13A4	1076	Q4VNC1
NLIFFILCTFVQLLG	ATP7B	696	P35670
QALVTLVVVLFALCF	GPR31	221	O00270
EVLLTFKIFLVIICL	ADGRG2	16	Q8IZP9
KNLCISLFVAELLFL	ADGRL3	901	Q9HAR2
FASLLIKCVVQLELI	ARFGEF2	1546	Q9Y6D5
VAKTVFCLVLVFALC	EDNRB	321	P24530
LKVLQQFAACFLETL	CHAF1A	701	Q13111
QQALSILLVKFFIIL	NBEAL1	86	Q6ZS30
ILLVKFFIILCRNLS	NBEAL1	91	Q6ZS30
ILLAKCLTVLGFVIF	OCA2	621	Q04671
AQLLALVLELLTFCV	PPP4R3A	506	Q6IN85
FLISACFKLIQDLLS	ABCC3	311	O15438
ILKVLVFNFLNCFAS	ANO10	401	Q9NW15
LVLLAGVCVFVLFQI	OTOP3	346	Q7RTS5
ALKEISLFLILCNIT	OTOP3	526	Q7RTS5
VINSCKILATFLLIL	OR6N1	201	Q8NGY5
LTLKDLLFSVCALNV	FAM189A1	171	O60320
VKFLAITTDCLQILA	CTNNB1	291	P35222
VFACLFLSTLLLVLN	NTRK1	426	P04629
LLKIFCQLFSIHVDA	KIAA0100	126	Q14667
LLLLVFLVACFINRK	FRAS1	3911	Q86XX4
ILILNVVAFFIICAC	LHCGR	531	P22888
LLKIVQAFVACIIFG	MYADML2	166	A6NDP7
LILILSVIFIKGNCA	MAGEC3	276	Q8TD91
VCFIAVKTLSLIGQL	MCMDC2	76	Q4G0Z9
VNFVVCQLFALLAAI	MBOAT2	26	Q6ZWT7
NLFKLIVNSLCPVIF	MCM8	401	Q9UJA3
TLFLLGAFNVCNKII	ITPR1	2361	Q14643
VLSLFCAVLTENKVL	SBF2	211	Q86WG5
KIFVFILAALILLAQ	DEFB107A	6	Q8IZN7
LFNLAVADFLLIICL	HCAR2	66	Q8TDS4
ASLLFLLVNVLCAVL	GPR137	146	Q96N19
FLCKLIHIVVDINLF	FPR2	96	P25090
LLFAIVTTLCLVRKF	LMBR1	436	Q8WVP7
SVVFLFCLLLLVLFC	LAIR1	171	Q6GTX8
VVLFLCTFKDITLFK	KCNH5	121	Q8NCM2
LALCISEIIIKILFN	FSIP2	3556	Q5CZC0
LDALICNKSFLVTVI	PLXNC1	1056	O60486
SLVQCILQVFFFIAL	OR14J1	91	Q9UGF5
SFLGCVLQLFLVVLL	OR14K1	91	Q8NGZ2
FLLISCGVILNFLKT	OR4A16	211	Q8NH70
IIFLLKRLTFCQNNI	OR52B4	161	Q8NGK2
VIIALLIIAAKCYFL	PECAM1	611	P16284
VSLALAFLACIVFLV	NSG2	76	Q9Y328
RLVACITTLFLFSKI	NIPBL	2001	Q6KC79
GQVFILNILFFCLLL	OPN5	196	Q6U736
FLQILPVLDFCKVFL	KLHL9	131	Q9P2J3
LCFSILLVLCIFIQS	LIPC	6	P11150
LKVLETFVACIIFAF	MYADM	176	Q96S97
AICFILAAIAILLNL	MYADM	211	Q96S97
LVLFALAFLTCVVFL	NSG1	86	P42857
IFTICVSFLQKRLCL	KLHL40	116	Q2TBA0
NCLTKILFGALVVVS	ATP9A	301	O75110
LLAFFILACVLIIFL	LRRC70	531	Q7Z2Q7
LVVCLGLVIRKFLNS	PAQR9	356	Q6ZVX9
CLKNVFSVLLIFIYL	PACC1	61	Q9H813
KASLLILVIFTICFA	F2RL2	301	O00254
FAVLLNSLILAKCFR	HFM1	906	A2PYH4
LAVFIDFLLQITCFV	NPC1	766	O15118
KVLRNIAAFLFLCNI	OTOP1	541	Q7RTM1
AIFILVCIESVFKKL	ADCY2	91	Q08462
VCIESVFKKLLRLFS	ADCY2	96	Q08462
FFCIFIVQILVLPKT	ADCY2	611	Q08462
FSSGLNKCVILALVI	CCPG1	211	Q9ULG6
VQLIEVVKFCCSFLL	KLHL15	111	Q96M94
LIQKLAACFFTLSII	CASD1	311	Q96PB1
FEIIILLTIFANCVA	CACNA1C	126	Q13936
VCLKLIKVFVLTSNF	ARV1	206	Q9H2C2
VLAFIFLNCITIALE	CACNA1I	1176	Q9P0X4
KFFQTFALLEIVHCL	HACD1	116	B0YJ81
ILLLLVVFLYKCFQG	C2orf74	21	A8MZ97
LLELSKSIRVFCIIF	C1GALT1C1L	61	P0DN25
ILSLFCFKLFVKISL	ASB5	21	Q8WWX0
LVAALVCFLLLAKTG	CEACAM3	166	P40198
LFLGAIFQLICVLAI	MANBAL	26	Q9NQG1
KFVLLLVFSAFITLC	MAN1A1	41	P33908
IFCKQLLFSLLVLTL	DSC1	11	Q08554
LKILGLLAVVVAFFC	FMO2	516	Q99518
KTIFILFLVITSCLC	GJB7	176	Q6PEY0
IVLNFIELSFLVLKC	GJB7	191	Q6PEY0
VLCTVTLFLLQLKFL	GPX8	26	Q8TED1
NFCLLEVLIIVFLTV	GPR21	26	Q99679
NFVRCLVRLETLFKI	CAPN2	661	P17655
NKFASLFLACVIVSI	SLC12A6	341	Q9UHW9
LFAALLLVVCVIFAI	SLC15A1	651	P46059
VFILICCFIILENIF	S1PR1	51	P21453
CCFIILENIFVLLTI	S1PR1	56	P21453
KFNIAVGLILCISLV	DSEL	771	Q8IZU8
FILLAIFANCVALAI	CACNA1D	131	Q01668
LSFISLELCVLQKLT	LRRC40	461	Q9H9A6
LFVVVVCLAAFLIFL	LSR	261	Q86X29
TVLCDIILLNFLKGA	P2RX3	336	P56373
AVLQLQDCSIFIKII	NUMA1	26	Q14980
NKFALVFLGCVILSI	SLC12A5	276	Q9H2X9
LFLFLGLKQVCATRQ	IPO8	866	O15397
KEFITLLISLCVLVL	OR10J4	196	P0C629
ALILINVVLDFCCFI	OR14A16	196	Q8NHC5
QTGIFLLCLIILIFF	OR2L13	21	Q8N349
LAKSLAILLGVFAVC	HRH4	301	Q9H3N8
KALQTVIFFLLLCAV	TAS2R31	226	P59538
KALQTVISFLLLCAI	TAS2R43	226	P59537
KALQTLISFLLLCAI	TAS2R50	226	P59544
HTKLFVFLAVLICLV	TMEM106A	91	Q96A25
KNVVFILQFLLSCFL	SLC35D2	236	Q76EJ3
QEFVCLKFIILFSLD	NR5A1	366	Q13285
SLVALALIFAIQKCD	SMC3	1121	Q9UQE7
IFALVCCFAILVALI	PLD5	71	Q8N7P1
LAILVFLINCATFAL	TMEM132C	936	Q8N3T6
AILVFLINCIVFVLR	TMEM132E	901	Q6IEE7
CLLVLSFAIKVLFSL	TMEM161B	141	Q8NDZ6
CSVNILQFIFIALRL	TMEM185A	146	Q8NFB2
CSVNILQFIFIALKL	TMEM185B	146	Q9H7F4
LNFALKCIFTVLIVL	PKDREJ	2001	Q9NTG1
KCIFTVLIVLFLRKH	PKDREJ	2006	Q9NTG1
LFNLAVADFLLIICL	HCAR3	66	P49019
IFICAFALVTLLQQI	ST8SIA5	21	O15466
ITALFLLAIFCKRVT	SLC5A9	471	Q2M3M2
LVKTLLDVNLIFCVS	SLC5A11	651	Q8WWX8
VSLFLTIKLFKLSFC	OR8K1	161	Q8NGG5
KVHLFTLIQLTCLVL	SLC4A8	951	Q2Y0W8
VFIQCVINAVFAKIL	SLC35B1	56	P78383
KLFTAIRALFLAVCV	TMEM176B	201	Q3YBM2
ACILNFQRALALFVI	SLC28A2	96	O43868
TCLVIFVLVHSFLKK	SLC28A2	111	O43868
LKNISVLAFSVCFIF	SLC29A1	286	Q99808
FCFILIQLVLLIDFA	SERINC1	161	Q9NRX5
LIKVACFLLLAAISL	PIGW	336	Q7Z7B1
QLTKAVVLACLLDFL	TENT5B	141	Q96A09
KLLQEIHSLLCFLVF	BRS3	211	P32247
ICLFTVIVPQKLLEF	ALG10	401	Q5BKT4
VFSLLKISQRIVCLV	CLCA4	296	Q14CN2
ESLQFLLDTCKVLVI	UBA3	61	Q8TBC4
QIFLTFCKLTAILII	SLC7A11	191	Q9UPY5
LCISLVTFVLQLFLF	ZDHHC22	16	Q8N966
LQKVFVQILVKLCSF	WDFY3	186	Q8IZQ1
FLHIFLLLQKISVSL	LINC00052	16	Q96N35
FLFLVFIILVVSCSQ	TM9SF4	536	Q92544
IIVLSIINFFERLCL	PHTF1	526	Q9UMS5
FAIQCSRILKLTLFV	TFG	76	Q92734
SKNLLLVALCLTFGV	TMEM164	91	Q5U3C3
VSTAKCQLLFALKVL	NUDT16L1	166	Q9BRJ7
FVILALQLLLACSLE	WDR97	1271	A6NE52
LCQLESFKALLIQAV	TPRG1L	206	Q5T0D9
VVVKALCAAVLFLYL	TMEM115	21	Q12893
LLLLLLCFVAVSFNT	PKD2L2	321	Q9NZM6
ENKFFISINLILCVV	SERINC3	236	Q13530
NQFLTLFCVKDLEIL	TRIM60	101	Q495X7
AQKTCFIILSKLVEL	XPOT	841	O43592
FTDLFLIICIILNVC	SCN7A	506	Q01118
KKLVNVIILTFFCLS	SCN11A	251	Q9UI33
LVAVLQVCTLKRFFQ	TMED1	206	Q13445
AVVSVIFLKVCKLFL	TMTC3	101	Q6ZXV5
KALLVLLSLGCFFSV	WDR11	1126	Q9BZH6
EVFLAKLIAQACVSI	CCT8	176	P50990
SKALIAFLAFLIIVT	PTPRC	576	P08575
ICNSLAIIFTLIVGK	TMEM234	86	Q8WY98
IKENKCLLLSFFIVL	TSPAN9	76	O75954
ESKCALVTFFFILLL	TSPAN1	81	O60635
FLKSSLNIIDCVAIL	KCNC3	376	Q14003
LKILCTATILFIFGI	NAALADL2	126	Q58DX5
IDKLILIQACVRAFL	MYO3A	1056	Q8NEV4