Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphatidylinositol-5-phosphate binding	WASHC2C WASHC2A SH3PXD2A	1.10e-05	23	38	3	GO:0010314
GeneOntologyMolecularFunction	phosphatidylinositol-3,4-bisphosphate binding	WASHC2C WASHC2A SH3PXD2A	3.99e-05	35	38	3	GO:0043325
GeneOntologyMolecularFunction	phosphatidylinositol-4-phosphate binding	WASHC2C WASHC2A SH3PXD2A	4.35e-05	36	38	3	GO:0070273
GeneOntologyMolecularFunction	phosphatidylinositol-3-phosphate binding	WASHC2C WASHC2A SH3PXD2A	1.04e-04	48	38	3	GO:0032266
GeneOntologyMolecularFunction	retromer complex binding	WASHC2C WASHC2A	1.57e-04	10	38	2	GO:1905394
GeneOntologyMolecularFunction	phosphatidylinositol-4,5-bisphosphate binding	WASHC2C WASHC2A SH3PXD2A	7.80e-04	95	38	3	GO:0005546
GeneOntologyMolecularFunction	hyaluronic acid binding	SUSD5 IMPG2	1.39e-03	29	38	2	GO:0005540
GeneOntologyMolecularFunction	phosphatidylinositol bisphosphate binding	WASHC2C WASHC2A SH3PXD2A	1.57e-03	121	38	3	GO:1902936
GeneOntologyMolecularFunction	phosphatidylinositol-3,5-bisphosphate binding	WASHC2C WASHC2A	1.58e-03	31	38	2	GO:0080025
GeneOntologyMolecularFunction	phosphatidylinositol binding	WASHC2C WASHC2A SH3PXD2A RPS6KC1	2.97e-03	316	38	4	GO:0035091
Domain	FAM21	WASHC2C WASHC2A	3.82e-06	2	37	2	IPR027308
Domain	FAM21/CAPZIP	WASHC2C WASHC2A	1.14e-05	3	37	2	IPR029341
Domain	CAP-ZIP_m	WASHC2C WASHC2A	1.14e-05	3	37	2	PF15255
Domain	SEA	MUC16 IMPG2	3.42e-04	14	37	2	SM00200
Domain	-	MUC16 IMPG2	3.95e-04	15	37	2	3.30.70.960
Domain	SEA	MUC16 IMPG2	8.60e-04	22	37	2	PF01390
Domain	SEA	MUC16 IMPG2	9.41e-04	23	37	2	PS50024
Domain	SEA_dom	MUC16 IMPG2	9.41e-04	23	37	2	IPR000082
Domain	PX	SH3PXD2A RPS6KC1	3.43e-03	44	37	2	SM00312
Domain	PX	SH3PXD2A RPS6KC1	4.24e-03	49	37	2	PF00787
Domain	TPR_2	LONRF3 TTC16	4.41e-03	50	37	2	PF07719
Domain	PX	SH3PXD2A RPS6KC1	4.41e-03	50	37	2	PS50195
Domain	TPR_2	LONRF3 TTC16	4.41e-03	50	37	2	IPR013105
Domain	-	SH3PXD2A RPS6KC1	4.58e-03	51	37	2	3.30.1520.10
Domain	Sushi	SUSD5 SVEP1	4.76e-03	52	37	2	PF00084
Domain	Phox	SH3PXD2A RPS6KC1	4.76e-03	52	37	2	IPR001683
Domain	CCP	SUSD5 SVEP1	5.12e-03	54	37	2	SM00032
Domain	SUSHI	SUSD5 SVEP1	5.50e-03	56	37	2	PS50923
Domain	Sushi_SCR_CCP_dom	SUSD5 SVEP1	5.69e-03	57	37	2	IPR000436
Domain	USP_CS	USP26 USP34	7.56e-03	66	37	2	IPR018200
Domain	USP_1	USP26 USP34	8.47e-03	70	37	2	PS00972
Domain	UCH	USP26 USP34	8.71e-03	71	37	2	PF00443
Domain	USP_2	USP26 USP34	8.71e-03	71	37	2	PS00973
Domain	USP_3	USP26 USP34	8.95e-03	72	37	2	PS50235
Domain	USP_dom	USP26 USP34	8.95e-03	72	37	2	IPR028889
Domain	Peptidase_C19_UCH	USP26 USP34	8.95e-03	72	37	2	IPR001394
Domain	G-protein_beta_WD-40_rep	NLE1 WDR1	1.23e-02	85	37	2	IPR020472
Pubmed	Identification of a novel Rev-interacting cellular protein.	WASHC2C WASHC2A	1.16e-06	2	38	2	15847701
Pubmed	SET protein (TAF1beta, I2PP2A) is involved in neuronal apoptosis induced by an amyloid precursor protein cytoplasmic subdomain.	SET APP	1.16e-06	2	38	2	16162853
Pubmed	Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp).	WASHC2C WASHC2A	1.16e-06	2	38	2	20827171
Pubmed	FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function against Candida albicans.	WASHC2C WASHC2A	1.16e-06	2	38	2	36717248
Pubmed	Increased expression of reticulon 3 in neurons leads to reduced axonal transport of β site amyloid precursor protein-cleaving enzyme 1.	RTN3 APP	3.48e-06	3	38	2	24005676
Pubmed	PAT1 induces cell death signal and SET mislocalization into the cytoplasm by increasing APP/APLP2 at the cell surface.	SET APP	3.48e-06	3	38	2	19570594
Pubmed	Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry.	USP34 GVINP1	3.48e-06	3	38	2	17203969
Pubmed	PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.	SCYL1 SET CEP192 THRAP3 ARFGAP1	7.19e-06	247	38	5	32989298
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	USP34 EFL1 SET WDR1 CDK12 THRAP3 ZMYND8 ILKAP	1.14e-05	1014	38	8	32416067
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	USP34 TICRR SET CEP192 WASHC2C WASHC2A ARFGAP1 RPS6KC1	1.85e-05	1084	38	8	11544199
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	RTN3 CASC3 L3MBTL1 APP THRAP3 ZMYND8	3.02e-05	560	38	6	21653829
Pubmed	A FAM21-containing WASH complex regulates retromer-dependent sorting.	WASHC2C WASHC2A	3.24e-05	8	38	2	19922874
Pubmed	The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex.	WASHC2C WASHC2A	7.62e-05	12	38	2	19922875
Pubmed	Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour.	WASHC2C WASHC2A	7.62e-05	12	38	2	27390154
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	NLE1 EFL1 WDR1 CDK12 ZMYND8 ILKAP	1.07e-04	704	38	6	29955894
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	SCYL1 RTN3 CASC3 TNRC6C WASHC2A THRAP3 ARFGAP1	1.16e-04	1038	38	7	26673895
Pubmed	Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.	WASHC2C WASHC2A	1.21e-04	15	38	2	28892079
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	SET WASHC2A CDK12 ZMYND8 ILKAP	1.56e-04	472	38	5	38943005
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	USP34 NLE1 CRYBG2 CEP192 TNRC6C WASHC2A CDK12	1.71e-04	1105	38	7	35748872
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	SCYL1 MUC16 USP34 CEP192 THRAP3 ARFGAP1	1.83e-04	777	38	6	35844135
Pubmed	COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.	WASHC2C WASHC2A	1.96e-04	19	38	2	25355947
Pubmed	Placentation defects are highly prevalent in embryonic lethal mouse mutants.	WASHC2C WASHC2A SH3PXD2A	1.97e-04	103	38	3	29539633
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	RTN3 WASHC2C APP WASHC2A THRAP3 ARFGAP1 RPS6KC1	2.06e-04	1139	38	7	36417873
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	USP34 WASHC2C SUSD5	2.09e-04	105	38	3	9628581
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	SET WDR1 WASHC2A CDK12 THRAP3	2.16e-04	506	38	5	30890647
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	USP34 SET WASHC2A ZMYND8	2.51e-04	282	38	4	23667531
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	SET CDK12 THRAP3 ZMYND8	2.55e-04	283	38	4	30585729
Pubmed	Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous KrasG12D.	WASHC2C WASHC2A	2.90e-04	23	38	2	31748650
Pubmed	Functional genetic analysis of mouse chromosome 11.	NLE1 WDR1	2.90e-04	23	38	2	12955145
Pubmed	High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.	TNRC6C LONRF3 THRAP3 SUSD5	3.47e-04	307	38	4	37499664
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	SCYL1 USP34 CEP192 CDK12 SH3PXD2A THRAP3	4.26e-04	910	38	6	36736316
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	USP34 RTN3 CEP192 WASHC2C WASHC2A	4.30e-04	588	38	5	38580884
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	WDR1 WASHC2C CDK12 ARFGAP1 ZMYND8 ILKAP	4.89e-04	934	38	6	33916271
Pubmed	HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.	SET THRAP3 ZMYND8	5.71e-04	148	38	3	32538781
Pubmed	CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†.	USP26 TMEM19	6.38e-04	34	38	2	31201419
Pubmed	Analysis of Ku70 S155 Phospho-Specific BioID2 Interactome Identifies Ku Association with TRIP12 in Response to DNA Damage.	SET CDK12 ILKAP	6.65e-04	156	38	3	37108203
Pubmed	Genomic analysis of mouse retinal development.	SET WASHC2C WASHC2A THRAP3 IMPG2 ILKAP	7.22e-04	1006	38	6	15226823
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	SCYL1 USP34 EFL1 SET WDR1 WASHC2A ARFGAP1	8.93e-04	1455	38	7	22863883
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	RTN3 NLE1 APP TMEM19 ARFGAP1	9.25e-04	697	38	5	28298427
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CEP192 TNRC6C WASHC2C WASHC2A	9.96e-04	407	38	4	12693553
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	RTN3 CASC3 CEP192 TNRC6C APP SH3PXD2A THRAP3	1.02e-03	1489	38	7	28611215
Cytoband	20q13.12	L3MBTL1 ZMYND8	1.15e-03	60	38	2	20q13.12
Cytoband	17q12	NLE1 CDK12	3.08e-03	99	38	2	17q12
Cytoband	11q13	SCYL1 RTN3	4.33e-03	118	38	2	11q13
Cytoband	Ensembl 112 genes in cytogenetic band chr20q13	L3MBTL1 ARFGAP1 ZMYND8	5.13e-03	422	38	3	chr20q13
Cytoband	Ensembl 112 genes in cytogenetic band chr12q21	LRRIQ1 TMEM19	6.12e-03	141	38	2	chr12q21
Cytoband	Ensembl 112 genes in cytogenetic band chr17q12	NLE1 CDK12	6.81e-03	149	38	2	chr17q12
GeneFamily	WASH complex	WASHC2C WASHC2A	2.97e-05	6	26	2	1331
GeneFamily	Ubiquitin specific peptidases	USP26 USP34	2.92e-03	56	26	2	366
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SUSD5 SVEP1	3.02e-03	57	26	2	1179
Disease	Paroxysmal atrial fibrillation	USP34 WDR1 SH3PXD2A	9.87e-04	156	37	3	C0235480
Disease	Persistent atrial fibrillation	USP34 WDR1 SH3PXD2A	9.87e-04	156	37	3	C2585653
Disease	familial atrial fibrillation	USP34 WDR1 SH3PXD2A	9.87e-04	156	37	3	C3468561
Disease	Atrial Fibrillation	USP34 WDR1 SH3PXD2A	1.06e-03	160	37	3	C0004238
Disease	Tourette syndrome	MUC16 EFL1	1.80e-03	50	37	2	EFO_0004895
Disease	Necrosis	SET APP	2.18e-03	55	37	2	C0027540
Disease	Cerebrovascular accident	APP SH3PXD2A	2.76e-03	62	37	2	C0038454
Disease	spontaneous preterm birth	KLHL1 SVEP1	7.15e-03	101	37	2	EFO_0006917
Disease	multiple myeloma	TICRR DSEL	8.72e-03	112	37	2	EFO_0001378

Protein segments in the cluster

Peptide	Gene	Start	Entry
SGNISVSWPATKESK	USP26	581	Q9BXU7
KWSDSSKQDDSPSGA	CDK12	226	Q9NYV4
KWDSDPSGTKTCIDT	APP	51	P05067
SVWTGPADKASKEAS	EFL1	846	Q7Z2Z2
STSVAKDKSSTASEW	GVINP1	2196	Q7Z2Y8
EPTKTRKSPSSDSWT	ARFGAP1	336	Q8N6T3
SDSWNEKEKSTPSAP	MUC16	3866	Q8WXI7
TDFTSSAKTSSPDWP	MUC16	10201	Q8WXI7
SASSLTSKWVGEGEK	FIGNL1	466	Q6PIW4
KWPDSGSSSEEECTT	RPS6KC1	496	Q96S38
ESEEWSSSQPATGEK	L3MBTL1	256	Q9Y468
SSSQPATGEKKECWS	L3MBTL1	261	Q9Y468
WSSDEEDGSKGRSKS	PLEKHH2	286	Q8IVE3
ENKTSSWTPESKTSR	LRRIQ1	1516	Q96JM4
TKTGTWEAPVDSSTS	CASC3	446	O15234
ASAASSPTWKEVVKG	CRYBG2	486	Q8N1P7
ASSQKPAWKDGSTAT	ILKAP	206	Q9H0C8
WSKDPSSKSGNLLET	CEP192	1136	Q8TEP8
SNKSSWSSSDEKRGS	ZMYND8	1146	Q9ULU4
WTRTEAEGSKKSLSS	DSEL	831	Q8IZU8
SKKTESSSRTADPWE	C4orf19	61	Q8IY42
TPITKSTGDWAEASL	RTN3	396	O95197
SGSSDSTLKVWDVKA	NLE1	431	Q9NVX2
SKAGDPVVSSSDESW	SUSD5	356	O60279
GKLSDIKSTWSSGPT	TNRC6C	1436	Q9HCJ0
SDHKSSKSPESDWSS	SCYL1	681	Q96KG9
SGDPSSKSTEIKWKS	SET	161	Q01105
SASGDKTSKIWDVSV	WDR1	251	O75083
WSETSSEKSAEPLSK	IMPG2	616	Q9BZV3
EKKSTCEATGQWSSP	SVEP1	2181	Q4LDE5
SQDTKASESSKPWPD	THRAP3	211	Q9Y2W1
DSEVSKSKEGSPSWS	TICRR	1796	Q7Z2Z1
PWTSSGTDTKKSVSR	CD96	446	P40200
SSWAESPKKDVTGAD	SH3PXD2A	146	Q5TCZ1
DLFSSSSPWDKGTKP	WASHC2C	781	Q9Y4E1
DTWASEVGPVLSKSS	TMEM19	186	Q96HH6
DLFSSSSPWDKGTKP	WASHC2A	781	Q641Q2
SKAESTWGPSPSLSK	TTC16	846	Q8NEE8
KSSDPFSLWSTDEKE	USP34	141	Q70CQ2
ERSGVSTFWKKPSSS	KLHL1	61	Q9NR64
WDATSPKAASSKTGK	LONRF3	401	Q496Y0