Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	PLC activating G protein-coupled glutamate receptor activity	GRM1 GRM5	3.76e-05	2	123	2	GO:0001639
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR5P2 OR6B1 OR5AK2 OR1B1 OR5L1 OR4F4 ADGRB2 NMUR2 GRM1 GRM5 FZD8 CELSR1 OR4C15 OR4C46 OR4F17 OR6K3	1.06e-04	884	123	16	GO:0004930
GeneOntologyMolecularFunction	nuclear receptor binding	UBA3 TACC2 GRM1 TRIM24 LRP2 PKN1 NR1H4	1.61e-04	187	123	7	GO:0016922
GeneOntologyMolecularFunction	neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	GRM1 GRM5	2.24e-04	4	123	2	GO:0099583
GeneOntologyMolecularFunction	RNA polymerase II-specific DNA-binding transcription factor binding	BBS2 UBA3 TACC2 REST GRM1 TRIM24 LRP2 PKN1 EPAS1 NR1H4	2.61e-04	417	123	10	GO:0061629
GeneOntologyMolecularFunction	olfactory receptor activity	OR5P2 OR6B1 OR5AK2 OR1B1 OR5L1 OR4F4 OR4C15 OR4C46 OR4F17 OR6K3	3.39e-04	431	123	10	GO:0004984
GeneOntologyMolecularFunction	G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential	GRM1 GRM5	3.72e-04	5	123	2	GO:0099530
GeneOntologyMolecularFunction	histone H3K27me2/H3K27me3 demethylase activity	KDM6A UTY	3.72e-04	5	123	2	GO:0071558
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR5P2 OR6B1 OR5AK2 OR1B1 OR5L1 C17orf99 OR4F4 ADGRB2 IL17RC NMUR2 GRM1 GRM5 FZD8 CELSR1 OR4C15 P2RX7 OR4C46 OR4F17 OR6K3	6.10e-04	1353	123	19	GO:0004888
GeneOntologyMolecularFunction	oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor	MTRR STEAP1B	7.75e-04	7	123	2	GO:0016723
GeneOntologyBiologicalProcess	sensory perception	OR5P2 OR6B1 OR5AK2 OR1B1 OR5L1 OR4F4 BBS2 REST NMUR2 GRM1 OR4C15 P2RX7 CRYGN MYH14 RP1L1 OR4C46 LRP2 OR4F17 OR6K3 EPAS1	4.68e-06	1072	122	20	GO:0007600
Domain	DUF4195	ZNF280A ZNF280D ZNF280B	1.06e-06	4	121	3	IPR025243
Domain	DUF4195	ZNF280A ZNF280D ZNF280B	1.06e-06	4	121	3	PF13836
Domain	GluR_Homer-bdg	GRM1 GRM5	4.16e-05	2	121	2	PF10606
Domain	Metabotropic_Glu_rcpt_Homer-bd	GRM1 GRM5	4.16e-05	2	121	2	IPR019588
Domain	GPCR_3_mtglu_rcpt_1	GRM1 GRM5	4.16e-05	2	121	2	IPR001256
Domain	GluR_Homer-bdg	GRM1 GRM5	4.16e-05	2	121	2	SM01229
Domain	GPCR_3_mtglu_rcpt_5	GRM1 GRM5	4.16e-05	2	121	2	IPR000202
Domain	Olfact_rcpt	OR5P2 OR6B1 OR5AK2 OR1B1 OR5L1 OR4F4 OR3A4P OR4C15 OR4C46 OR4F17 OR6K3	5.01e-05	393	121	11	IPR000725
Domain	-	NID2 TRIM56 LRP2 PAM	1.16e-04	39	121	4	2.120.10.30
Domain	6-blade_b-propeller_TolB-like	NID2 TRIM56 LRP2 PAM	2.22e-04	46	121	4	IPR011042
Pubmed	UTX Affects Neural Stem Cell Proliferation and Differentiation through PTEN Signaling.	PTEN KDM6A UTY	1.53e-06	7	124	3	29551674
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR5P2 OR6B1 OR5AK2 OR1B1 OR5L1 OR4F4 OR4C15 OR4C46 OR6K3	3.88e-06	340	124	9	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR5P2 OR6B1 OR5AK2 OR1B1 OR5L1 OR4F4 OR4C15 OR4C46 OR6K3	3.88e-06	340	124	9	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR5P2 OR6B1 OR5AK2 OR1B1 OR5L1 OR4F4 OR4C15 OR4C46 OR6K3	4.17e-06	343	124	9	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR5P2 OR6B1 OR5AK2 OR1B1 OR5L1 OR4F4 OR4C15 OR4C46 OR6K3	4.48e-06	346	124	9	14611657
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	MYCL ZNF280D ETV5 ZNF280B REST TRIM24 ZYX ZNF718 KDM6A UTY EPAS1 MBNL3 MYBL2	6.70e-06	808	124	13	20412781
Pubmed	Cyclic ADP ribose-dependent Ca2+ release by group I metabotropic glutamate receptors in acutely dissociated rat hippocampal neurons.	GRM1 GRM5	1.26e-05	2	124	2	22028929
Pubmed	Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP.	GRM1 GRM5	1.26e-05	2	124	2	9185557
Pubmed	Hypoxia-inducible factor-2α stabilizes the von Hippel-Lindau (VHL) disease suppressor, Myb-related protein 2.	EPAS1 MYBL2	1.26e-05	2	124	2	28394947
Pubmed	An H-YDb epitope is encoded by a novel mouse Y chromosome gene.	KDM6A UTY	1.26e-05	2	124	2	8944031
Pubmed	mGluR₁,5 activation improves network asynchrony and GABAergic synapse attenuation in the amygdala: implication for anxiety-like behavior in DBA/2 mice.	GRM1 GRM5	1.26e-05	2	124	2	22681774
Pubmed	mGluR1,5 activation protects cortical astrocytes and GABAergic neurons from ischemia-induced impairment.	GRM1 GRM5	1.26e-05	2	124	2	23280324
Pubmed	Metabotropic glutamate receptors in the main olfactory bulb drive granule cell-mediated inhibition.	GRM1 GRM5	1.26e-05	2	124	2	17093122
Pubmed	In-vivo genetic ablation of metabotropic glutamate receptor type 5 slows down disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis.	GRM1 GRM5	1.26e-05	2	124	2	31102766
Pubmed	Transcriptional activity of multiple copies of a subtelomerically located olfactory receptor gene that is polymorphic in number and location.	OR4F4 OR4F17	1.26e-05	2	124	2	11689484
Pubmed	Comparative sequencing of a multicopy subtelomeric region containing olfactory receptor genes reveals multiple interactions between non-homologous chromosomes.	OR4F4 OR4F17	1.26e-05	2	124	2	11689483
Pubmed	Corticostriatal LTP requires combined mGluR1 and mGluR5 activation.	GRM1 GRM5	1.26e-05	2	124	2	12559117
Pubmed	Involvement of group I metabotropic glutamate receptors and glutamate transporters in the slow excitatory synaptic transmission in the spinal cord dorsal horn.	GRM1 GRM5	1.26e-05	2	124	2	18554818
Pubmed	Regulation of multidrug resistance-associated protein 2 by calcium signaling in mouse liver.	ABCC3 ITPR2	1.26e-05	2	124	2	20578149
Pubmed	Group 1 metabotropic glutamate receptors 1 and 5 form a protein complex in mouse hippocampus and cortex.	GRM1 GRM5	1.26e-05	2	124	2	27392515
Pubmed	Genetic inactivation of mGlu5 receptor improves motor coordination in the Grm1crv4 mouse model of SCAR13 ataxia.	GRM1 GRM5	1.26e-05	2	124	2	28982591
Pubmed	Sex-specific differences in expression of histone demethylases Utx and Uty in mouse brain and neurons.	KDM6A UTY	1.26e-05	2	124	2	18434530
Pubmed	PRMT5-PTEN molecular pathway regulates senescence and self-renewal of primary glioblastoma neurosphere cells.	PTEN PRMT5	1.26e-05	2	124	2	27292259
Pubmed	Selective induction of metabotropic glutamate receptor 1- and metabotropic glutamate receptor 5-dependent chemical long-term potentiation at oriens/alveus interneuron synapses of mouse hippocampus.	GRM1 GRM5	1.26e-05	2	124	2	18035501
Pubmed	Target sequencing and CRISPR/Cas editing reveal simultaneous loss of UTX and UTY in urothelial bladder cancer.	KDM6A UTY	1.26e-05	2	124	2	27533081
Pubmed	Determination of group I metabotropic glutamate receptor subtypes involved in the frequency of epileptiform activity in vitro using mGluR1 and mGluR5 mutant mice.	GRM1 GRM5	1.26e-05	2	124	2	12623213
Pubmed	Group I metabotropic glutamate receptors mediate a dual role of glutamate in T cell activation.	GRM1 GRM5	1.26e-05	2	124	2	15184389
Pubmed	Purinergic ionotropic P2X7 and metabotropic glutamate mGlu5 receptors crosstalk influences pro-inflammatory conditions in microglia.	GRM5 P2RX7	1.26e-05	2	124	2	36435235
Pubmed	Atp8a1 deletion increases the proliferative activity of hematopoietic stem cells by impairing PTEN function.	PTEN ATP8A1	1.26e-05	2	124	2	36930333
Pubmed	Positive and negative selection on mammalian Y chromosomes.	KDM6A UTY	1.26e-05	2	124	2	15758204
Pubmed	PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation.	PTEN EPAS1	1.26e-05	2	124	2	25394489
Pubmed	Lysine demethylases KDM6A and UTY: The X and Y of histone demethylation.	KDM6A UTY	1.26e-05	2	124	2	31097364
Pubmed	Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons.	GRM1 GRM5	1.26e-05	2	124	2	11591458
Pubmed	Symmetric signal transduction and negative allosteric modulation of heterodimeric mGlu1/5 receptors.	GRM1 GRM5	1.26e-05	2	124	2	33279506
Pubmed	mGluR5 Is Substitutable for mGluR1 in Cerebellar Purkinje Cells for Motor Coordination, Developmental Synapse Elimination, and Motor Learning.	GRM1 GRM5	1.26e-05	2	124	2	35805089
Pubmed	Enhanced Function and Overexpression of Metabotropic Glutamate Receptors 1 and 5 in the Spinal Cord of the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis during Disease Progression.	GRM1 GRM5	1.26e-05	2	124	2	31540330
Pubmed	Differential distribution of group I metabotropic glutamate receptors in developing human cortex.	GRM1 GRM5	1.26e-05	2	124	2	20149785
Pubmed	Calcineurin inhibitor protein (CAIN) attenuates Group I metabotropic glutamate receptor endocytosis and signaling.	GRM1 GRM5	3.77e-05	3	124	2	19717561
Pubmed	Caspase-1 (interleukin-1beta-converting enzyme) is inhibited by the human serpin analogue proteinase inhibitor 9.	CASP4 SERPINB9	3.77e-05	3	124	2	10477277
Pubmed	Interleukin-17 promotes formation and growth of prostate adenocarcinoma in mouse models.	IL17RC PTEN	3.77e-05	3	124	2	22461511
Pubmed	Role of synaptic metabotropic glutamate receptors in epileptiform discharges in hippocampal slices.	GRM1 GRM5	3.77e-05	3	124	2	12364493
Pubmed	Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation.	REST GRM1	3.77e-05	3	124	2	25299066
Pubmed	Interleukin-17 promotes development of castration-resistant prostate cancer potentially through creating an immunotolerant and pro-angiogenic tumor microenvironment.	IL17RC PTEN	3.77e-05	3	124	2	24691769
Pubmed	Gene structure, chromosomal localization, and expression of the murine homologue of human proteinase inhibitor 6 (PI-6) suggests divergence of PI-6 from the ovalbumin serpins.	F2 SERPINB9	3.77e-05	3	124	2	7608171
Pubmed	The UTX gene escapes X inactivation in mice and humans.	KDM6A UTY	3.77e-05	3	124	2	9499428
Pubmed	Caspase-4 interacts with TNF receptor-associated factor 6 and mediates lipopolysaccharide-induced NF-kappaB-dependent production of IL-8 and CC chemokine ligand 4 (macrophage-inflammatory protein-1 ).	TRAF6 CASP4	3.77e-05	3	124	2	18056395
Pubmed	Association of MTHFR, MTRR and RAD54L Gene Variations with Meningioma and Correlation with Tumor's Histopathological Characteristics on Turkish Cohort.	MTRR RAD54L	3.77e-05	3	124	2	34169999
Pubmed	PTEN suppression of YY1 induces HIF-2 activity in von-Hippel-Lindau-null renal-cell carcinoma.	PTEN EPAS1	3.77e-05	3	124	2	19483472
Pubmed	Autophagy-linked FYVE containing protein WDFY3 interacts with TRAF6 and modulates RANKL-induced osteoclastogenesis.	TRAF6 WDFY3	3.77e-05	3	124	2	27330028
Pubmed	SIRT1 Activation Attenuates Bone Cancer Pain by Inhibiting mGluR1/5.	GRM1 GRM5	3.77e-05	3	124	2	31270711
Pubmed	Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome.	GRM1 GRM5	3.77e-05	3	124	2	20410124
Pubmed	Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors.	F2 SERPINB9	3.77e-05	3	124	2	8530382
Pubmed	The regulation of hippocampal LTP by the molecular switch, a form of metaplasticity, requires mGlu5 receptors.	GRM1 GRM5	3.77e-05	3	124	2	16024054
Pubmed	mGluR1 and mGluR5 Synergistically Control Cholinergic Synaptic Transmission in the Thalamic Reticular Nucleus.	GRM1 GRM5	3.77e-05	3	124	2	27466334
Pubmed	Genetic reduction of group 1 metabotropic glutamate receptors alters select behaviors in a mouse model for fragile X syndrome.	GRM1 GRM5	3.77e-05	3	124	2	21571007
Pubmed	Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome.	GRM1 GRM5	3.77e-05	3	124	2	20534533
Pubmed	Metabotropic glutamate receptors 1 and 5 differentially regulate bulbar dopaminergic cell function.	GRM1 GRM5	3.77e-05	3	124	2	20692242
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MYCL ABCC3 POLG ADGRB2 TRIM7 ITPR2 CELSR1 CHST15 SORBS3 CPSF1 PKN1 WDFY3 DYNC1H1 MYBL2	4.17e-05	1105	124	14	35748872
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DCHS2 TRAF6 TTC28 POLG CEP57L1 UBA3 ADAMTS8 MYH14 LRP2 FMN2 MACF1 WDFY3 KDM6A DYNC1H1 SOS2	5.54e-05	1285	124	15	35914814
Pubmed	Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system.	GRM1 GRM5	7.53e-05	4	124	2	29079293
Pubmed	SAMD9 Promotes Postoperative Recurrence of Esophageal Squamous Cell Carcinoma by Stimulating MYH9-Mediated GSK3β/β-Catenin Signaling.	TRAF6 SAMD9	7.53e-05	4	124	2	36757050
Pubmed	Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons.	GRM1 GRM5	7.53e-05	4	124	2	15745950
Pubmed	The Pannexin 1 Channel and the P2X7 Receptor Are in Complex Interplay to Regulate the Release of Soluble Ectonucleotidases in the Murine Bladder Lamina Propria.	CASP4 P2RX7	7.53e-05	4	124	2	37373111
Pubmed	Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family.	MYH14 MYH15	7.53e-05	4	124	2	11919279
Pubmed	Metabotropic glutamate receptors transduce signals for neurite outgrowth after binding of the prion protein to laminin γ1 chain.	GRM1 GRM5	7.53e-05	4	124	2	20876210
Pubmed	Decreased nociceptive sensitization in mice lacking the fragile X mental retardation protein: role of mGluR1/5 and mTOR.	GRM1 GRM5	7.53e-05	4	124	2	18094233
Pubmed	Graph complexity analysis identifies an ETV5 tumor-specific network in human and murine low-grade glioma.	ETV5 PTEN	7.53e-05	4	124	2	29787563
Pubmed	Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms.	KDM6A UTY	7.53e-05	4	124	2	9854018
Pubmed	Mapping of the 75-kDa inositol polyphosphate-5-phosphatase (Inpp5b) to distal mouse chromosome 4 and its exclusion as a candidate gene for dysgenetic lens.	MYCL INPP5B	7.53e-05	4	124	2	8530037
Pubmed	Genetics University of Toronto Thrombophilia Study in Women (GUTTSI): genetic and other risk factors for venous thromboembolism in women.	F2 MTRR	7.53e-05	4	124	2	11806787
Pubmed	Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes.	OR4F4 OR4F17	7.53e-05	4	124	2	9384599
Pubmed	Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression.	GRM1 GRM5	7.53e-05	4	124	2	15254091
Pubmed	X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.	KDM6A UTY	7.53e-05	4	124	2	32732223
Pubmed	TRAF6 Promotes PRMT5 Activity in a Ubiquitination-Dependent Manner.	TRAF6 PRMT5	7.53e-05	4	124	2	37173967
Pubmed	Female-specific dysfunction of sensory neocortical circuits in a mouse model of autism mediated by mGluR5 and estrogen receptor α.	PTEN GRM5	7.53e-05	4	124	2	38581678
Pubmed	Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility.	KDM6A UTY	7.53e-05	4	124	2	10767340
Pubmed	Do transmembrane domain neuregulin 1 mutant mice exhibit a reliable sensorimotor gating deficit?	GRM1 GRM5	7.53e-05	4	124	2	21605597
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	GPHN LARP1 TACC2 POLR1G ZYX STRIP1 MYPN SORBS3 PKN1	8.41e-05	503	124	9	16964243
Pubmed	Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human.	CRYGN WDFY3 UTY	8.48e-05	24	124	3	17452356
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	LARP1 REST POLR1G ZYX STRIP1 SORBS3 CPSF1 ANKRD17 PKN1 KDM6A MYBL2	1.07e-04	774	124	11	15302935
Pubmed	Cross-Species Genomics Identifies TAF12, NFYC, and RAD54L as Choroid Plexus Carcinoma Oncogenes.	PTEN RAD54L	1.25e-04	5	124	2	25965574
Pubmed	Dual metabotropic glutamate receptor signaling enables coordination of astrocyte and neuron activity in developing sensory domains.	GRM5 ITPR2	1.25e-04	5	124	2	34245686
Pubmed	Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation.	F2 P2RX7	1.25e-04	5	124	2	18305483
Pubmed	Dual Roles of RNF2 in Melanoma Progression.	PTEN KDM6A	1.25e-04	5	124	2	26450788
Pubmed	mGluR5 regulates REST/NRSF signaling through N-cadherin/β-catenin complex in Huntington's disease.	REST GRM5	1.25e-04	5	124	2	32859226
Pubmed	Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling.	STRIP1 SLMAP	1.25e-04	5	124	2	30622739
Pubmed	Hypoxia-inducible factor 2alpha regulates expression of the mitochondrial aconitase chaperone protein frataxin.	OGDH EPAS1	1.25e-04	5	124	2	17322295
Pubmed	HIF1α and HIF2α independently activate SRC to promote melanoma metastases.	PTEN EPAS1	1.25e-04	5	124	2	23563312
Pubmed	TRAF6 mediates ubiquitination of KIF23/MKLP1 and is required for midbody ring degradation by selective autophagy.	TRAF6 WDFY3	1.25e-04	5	124	2	24128730
Pubmed	Genetic susceptibility to distinct bladder cancer subphenotypes.	CYP1B1 PTEN POLR1G P2RX7 MTRR NR1H4 RAD54L MYBL2	1.40e-04	421	124	8	19692168
Pubmed	The human olfactory receptor gene family.	OR5P2 OR6B1 OR5AK2 OR1B1 OR5L1 OR4F4 OR3A4P OR4C15 OR6K3	1.45e-04	541	124	9	14983052
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	GPHN ADGRB2 GRM1 GRM5 STRIP1 P2RX7 PLPP3 ANKRD17 MACF1 PKN1 WDFY3 DYNC1H1	1.77e-04	963	124	12	28671696
Pubmed	Predictive role of coagulation-balance gene polymorphisms in the efficacy of photodynamic therapy with verteporfin for classic choroidal neovascularization secondary to age-related macular degeneration.	F2 MTRR	1.87e-04	6	124	2	18004208
Pubmed	The protein kinase C super-family member PKN is regulated by mTOR and influences differentiation during prostate cancer progression.	PTEN PKN1	1.87e-04	6	124	2	28875501
Pubmed	A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization.	GRM1 GRM5	1.87e-04	6	124	2	23911326
Pubmed	Homer: a protein that selectively binds metabotropic glutamate receptors.	GRM1 GRM5	1.87e-04	6	124	2	9069287
Pubmed	Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer.	GRM1 GRM5	1.87e-04	6	124	2	11418862
Pubmed	DNA primase from KB cells. Characterization of a primase activity tightly associated with immunoaffinity-purified DNA polymerase-alpha.	POLE2 PRIM2	1.87e-04	6	124	2	6693436
Pubmed	Vasculopathic and thrombophilic risk factors for spontaneous preterm birth.	F2 MTRR	1.87e-04	6	124	2	19336437
Pubmed	Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures.	PTEN PLPP3	1.87e-04	6	124	2	20123964
CoexpressionAtlas	FacebaseRNAseq_e10.5_Olfactory Pit_top-relative-expression-ranked_1000	MYCL ADGRB2 ETV5 TEX15 GSTM2 FZD8 CELSR1 CHST15 MYH14 TNN NECTIN2 SCUBE3 LRP2 FMN2 MACF1 UTY EPAS1 PSD4	3.36e-06	984	111	18	Facebase_RNAseq_e10.5_Olfactory Pit_1000
CoexpressionAtlas	gudmap_RNAseq_p2_Glomerlular Endothelial_2500_K4	DDX60 INPP5B CASP4 IL17RC SERPINB9 CHST15 P2RX7 CRYGN TRIM56 AMOTL1 EPAS1	6.70e-06	392	111	11	gudmap_RNAseq_p2_Glomerlular Endothelial_2500_K4
CoexpressionAtlas	gudmap_RNAseq_p2_CD2APMEISWT_2500_K4	CYP1B1 DDX60 INPP5B CASP4 IL17RC ITGA1 SERPINB9 CHST15 P2RX7 CRYGN TRIM56 AMOTL1 CD180 EPAS1 MBNL3	3.26e-05	842	111	15	gudmap_RNAseq_p2_CD2APMEISWT_2500_K4
CoexpressionAtlas	FacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_1000	ADGRB2 ETV5 GSTM2 FZD8 CELSR1 CHST15 MYH14 TNN NECTIN2 SCUBE3 LRP2 FMN2 EPAS1 MBNL3 RAD54L PSD4	4.56e-05	973	111	16	Facebase_RNAseq_e9.5_Olfactory Placode_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_1000_k-means-cluster#3	MYCL ZNF280D CEP57L1 BBS2 SLMAP MACF1 WDFY3	5.39e-05	185	111	7	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_1000_K3
CoexpressionAtlas	DevelopingGonad_e12.5_epididymis_emap-29139_top-relative-expression-ranked_1000	CYP1B1 REST PTEN TRIM24 GSTM2 ATP8A1 CHST15 PRMT5 ANKRD17 WDFY3 KDM6A UTY MBNL3 MYBL2	7.98e-05	806	111	14	gudmap_developingGonad_e12.5_epididymis_1000
ToppCell	(00)_Basal-(0)_uninjured\|(00)_Basal / shred by cell type and Timepoint	TTC28 GSTM2 FZD8 PLPP3 TRIM56 AMOTL1 EPAS1	8.42e-07	182	125	7	c02c9cab4389d80f318f4bb8d703c1e719672624
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRB2 ITGA1 PRIM2 MYH15 RAD54L MYBL2	8.91e-06	171	125	6	b0373ed8283ee1792b6a490bff93906546978593
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRB2 ITGA1 PRIM2 MYH15 RAD54L MYBL2	8.91e-06	171	125	6	b92963f9f247d2e5e2e6c51c6dbf70e527cd2f55
ToppCell	Thalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Thalamus / BrainAtlas - Mouse McCarroll V32	SHOX2 SLC24A3 GRM1 PIK3C2G AMOTL1	9.31e-06	100	125	5	20675fc2ffc5ab63047d38da083b50d470f3db19
ToppCell	Thalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6\|Thalamus / BrainAtlas - Mouse McCarroll V32	SHOX2 SLC24A3 GRM1 PIK3C2G AMOTL1	9.31e-06	100	125	5	1de3895e16f14ff32b901b18ce14d965afaa7e76
ToppCell	Thalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Rora\|Thalamus / BrainAtlas - Mouse McCarroll V32	SHOX2 SLC24A3 GRM1 PIK3C2G AMOTL1	9.31e-06	100	125	5	ff1bdb511700a041a90034d1d30dfc25f51d6c82
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Epcam____podocyte-3\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCL FZD8 CRYGN SCUBE3 FMN2 XRRA1	9.84e-06	174	125	6	76310c0af1d7df6a4de3816838b2ac2892f68746
ToppCell	COVID-19-kidney-Epi_(Mes)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ABCC3 DCHS2 GRM5 LRP2 FMN2 NR1H4	1.12e-05	178	125	6	544379f5a6145429762258d426b876bb36c112f5
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MYCL PLB1 ETV5 NECTIN2 SORBS3 EPAS1	1.19e-05	180	125	6	2bc3fd2e4c249bf236340c5f0483747faa5c04ec
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Myeloid-Dendritic-conventional_dendritic_cell\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MYCL PLB1 ETV5 NECTIN2 SORBS3 EPAS1	1.23e-05	181	125	6	1b4eb044825ede6361928442524b1988c8ef58b3
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Myeloid-Dendritic\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MYCL PLB1 ETV5 NECTIN2 SORBS3 EPAS1	1.23e-05	181	125	6	8d7ebbedc373d55e29da02ac2728b4f4118038f2
ToppCell	facs-Skin-Anagen-3m-Epithelial-Basal_IFE\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC24A3 TRIM7 CELSR1 PAM SLC22A20P MBNL3	1.27e-05	182	125	6	22d6f4790950508e8aa27e02a8133af5f53f13c8
ToppCell	droplet-Lung-LUNG-1m-Epithelial-type_II_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ETV5 TEX15 CELSR1 MYH14 NECTIN2 LRP2	1.27e-05	182	125	6	c1e0be27064e14043b78ae501b02d4e9542267a3
ToppCell	droplet-Lung-LUNG-1m-Epithelial-Alveolar_Epithelial_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ETV5 TEX15 CELSR1 MYH14 NECTIN2 LRP2	1.27e-05	182	125	6	3c9b4869d357884ae4bcd22a9872faf83a5cfc6d
ToppCell	droplet-Lung-1m-Epithelial-alveolar_epithelial-type_II_pneumocyte-type_2_alveolar_epithelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ETV5 TEX15 CELSR1 MYH14 NECTIN2 LRP2	1.35e-05	184	125	6	24cbe9f2461ea920954e44bf3b2c2a6a5d4debfb
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKD1L2 GRM1 MELTF PIK3C2G LRP2 MYH15	1.35e-05	184	125	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	droplet-Lung-1m-Epithelial-alveolar_epithelial-type_II_pneumocyte\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ETV5 TEX15 CELSR1 MYH14 NECTIN2 LRP2	1.35e-05	184	125	6	98079fd048a63b51bbdf3833b6f15bf0ae99ea90
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKD1L2 GRM1 MELTF PIK3C2G LRP2 MYH15	1.35e-05	184	125	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKD1L2 GRM1 MELTF PIK3C2G LRP2 MYH15	1.35e-05	184	125	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	droplet-Lung-1m-Epithelial-alveolar_epithelial\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ETV5 TEX15 CELSR1 MYH14 NECTIN2 LRP2	1.35e-05	184	125	6	86c1551c4f7c7d0c35c14852b01b1e602fa5092a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NID2 DCHS2 SLC24A3 ITGA1 PTEN CHST15	1.57e-05	189	125	6	71397e993a77d70b2eeede240bdfc7660b558987
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NID2 DCHS2 SLC24A3 ITGA1 PTEN CHST15	1.57e-05	189	125	6	4eea4759520c312bd17a681034d8074e47093d2b
ToppCell	Globus_pallidus-Endothelial\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	IL17RC ITGA1 GSTM2 SERPINB9 TRIM56 EPAS1	1.57e-05	189	125	6	ad7dc9d25edd68fb624380a082c389fe7d640e7d
ToppCell	RA-10._Endothelium_II\|World / Chamber and Cluster_Paper	CYP1B1 ITGA1 ITPR2 PLPP3 ZNF804B EPAS1	1.57e-05	189	125	6	75c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NID2 DCHS2 SLC24A3 ITGA1 SERPINB9 CHST15	1.67e-05	191	125	6	a6c57627077fa980b7ec1d3894b5f31bfb11b738
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ABCC3 CELSR1 ATP8A1 MYH14 ZNF804B LRP2	1.67e-05	191	125	6	60ff989fe99d243a3d52955223680cdd1f1917a4
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NID2 DCHS2 SLC24A3 ITGA1 SERPINB9 CHST15	1.67e-05	191	125	6	8f6d592edc32fdb901af30501d4360512334e8c2
ToppCell	Epithelial-alveolar_epithelial_cell_type_2\|World / Lineage, Cell type, age group and donor	GPHN ETV5 TACC2 ATP8A1 LRP2 MTRR	1.72e-05	192	125	6	58c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D122\|Adult / Lineage, Cell type, age group and donor	GPHN ETV5 TACC2 ATP8A1 LRP2 UTY	1.72e-05	192	125	6	06013a07e3a873b1d1c0451643c528593ac32a9c
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2\|Adult / Lineage, Cell type, age group and donor	GPHN ETV5 TACC2 ATP8A1 LRP2 MTRR	1.77e-05	193	125	6	738f4f0a9ddde2432b429ab46838e353b1790589
ToppCell	Control-Epithelial-ATII\|Epithelial / Disease state, Lineage and Cell class	GPHN ETV5 TACC2 ATP8A1 PLPP3 MACF1	1.82e-05	194	125	6	a01de094f7bfd099bcbb2f94224690a2efb887b4
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	GPHN TTC28 ITPR2 WDFY3 KDM6A UTY	2.10e-05	199	125	6	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	TRIM24 CELSR1 ATP8A1 MYH14 XRRA1 ZNF385C	2.10e-05	199	125	6	121de4e02585de3a3010398387c523bacf8ce546
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors\|1_mon / Sample Type, Dataset, Time_group, and Cell type.	LARP1 TRIM24 CELSR1 PLPP3 SORBS3 MYBL2	2.10e-05	199	125	6	358c4b3037f59378db8916a2fbe9ed4830cf1449
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Vcan_(SNc)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	GTSF1 MELTF PIK3C2G XRRA1	2.62e-05	61	125	4	12de8c495c7f47ecd720f29a573471705603732a
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Vcan_(SNc)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	GTSF1 MELTF PIK3C2G XRRA1	2.62e-05	61	125	4	a655232c6d92335eb086723ab9b05eb3a5479b68
ToppCell	facs-Heart-LV-24m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RNF183 GRM5 SLC22A20P MBNL3 MYBL2	5.22e-05	143	125	5	8f82b3c3331f20c6ded36dbfb9a48dbd9f099f93
ToppCell	facs-Heart-LV-24m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RNF183 GRM5 SLC22A20P MBNL3 MYBL2	5.22e-05	143	125	5	52832321cc848739ff6483f467d57c50c8b7395c
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	ITGA1 ATP8A1 MACF1 UTY DYNC1H1	5.95e-05	147	125	5	94998bc40f5c08295cfe3bdcbe43f13b1e564b3d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NID2 ADGRB2 SHOX2 TEX15 FMN2	7.88e-05	156	125	5	dd41ed918b07fa248da458a629b3c53cb7ea8764
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NID2 ADGRB2 SHOX2 TEX15 FMN2	7.88e-05	156	125	5	abf9dd075b1ca8f613c660cc82f8a5af071fb6ab
ToppCell	facs-Lung-24m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-natural_killer\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADGRB2 SERPINB9 CRYGN PRMT5 MBNL3	8.13e-05	157	125	5	34eb1cbdb023d3e23b2e1695c9c327c21ef1c870
ToppCell	facs-Lung-EPCAM-24m-Lymphocytic-Natural_Killer\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRB2 SERPINB9 CRYGN PRMT5 MBNL3	8.13e-05	157	125	5	071f10d749b590b75a07ab3c7b00956dc7cda4da
ToppCell	facs-Lung-24m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADGRB2 SERPINB9 CRYGN PRMT5 MBNL3	8.13e-05	157	125	5	fc0c222124f59c94d60335f849554eaa4062f8c7
ToppCell	facs-Lung-24m-Hematologic-Lymphocytic_NK_ILC\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADGRB2 SERPINB9 CRYGN PRMT5 MBNL3	8.13e-05	157	125	5	40b08ace1d9ea7951886f5fed76ac57e9175436b
ToppCell	facs-Lung-EPCAM-24m-Lymphocytic-NK_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRB2 SERPINB9 CRYGN PRMT5 MBNL3	8.13e-05	157	125	5	af110085dad5d26b0b7068a78f104ba784fa8564
ToppCell	343B-Epithelial_cells-Epithelial-A_(AT2)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	ETV5 TACC2 ATP8A1 LRP2 MTRR	9.98e-05	164	125	5	beaa13a75c3bb72446c85084d75e9fe3f15fd3d4
ToppCell	343B-Epithelial_cells-Epithelial-A_(AT2)\|343B / Donor, Lineage, Cell class and subclass (all cells)	ETV5 TACC2 ATP8A1 LRP2 MTRR	9.98e-05	164	125	5	d005cfd821b87548b075120bffe65a0be9860463
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Ptprt_Pkp2\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TRAF6 SLC24A3 TACC2 ADARB2 AMOTL1	1.18e-04	170	125	5	14aa86a4f526ed6986afcb28c49225522055550c
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DCHS2 ITGA1 ITPR2 PIK3C2G AMOTL1	1.25e-04	172	125	5	cecfe5cf20f317ea01b4604789e07a14481c4cd6
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-CD141+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	MYCL ZNF718 AMOTL1 MYH15 RAD54L	1.25e-04	172	125	5	1215f61f115b042f84721b64c2ed1f48081535f1
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_3\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	SHOX2 TRIM7 PRIM2 SLMAP PSD4	1.46e-04	178	125	5	9d575902d3dbe33437c9d4200df093a741269803
ToppCell	cellseq2-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ADGRB2 ADAMTS8 HOXB7 MYPN ZNF804B	1.46e-04	178	125	5	8ec2a25dda96c9cc9c2904b6cb18f75a293f4969
ToppCell	cellseq2-Mesenchymal-Fibroblastic-Fibroblastic_2\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ADGRB2 ADAMTS8 HOXB7 MYPN ZNF804B	1.46e-04	178	125	5	6c91331196696e0cf239d105f458e3230659fa38
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRAF6 RNF183 F2 CRYGN SCUBE3	1.46e-04	178	125	5	6178706db4a855d72abc156537604d575624df56
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRAF6 RNF183 F2 CRYGN SCUBE3	1.46e-04	178	125	5	f02076ece0fa899e620971c887ad4da7f48684ed
ToppCell	COVID-19-kidney-Epi_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	ABCC3 NID2 DCHS2 ITGA1 GRM5	1.50e-04	179	125	5	e7c9dc63f03d3f3746b51a7e3c8393089e2ceb7d
ToppCell	Control-Epithelial_cells-AT2\|Control / group, cell type (main and fine annotations)	GPHN ETV5 TACC2 ATP8A1 LRP2	1.54e-04	180	125	5	198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMTS8 ITGA1 ZYX SLMAP MACF1	1.58e-04	181	125	5	beb2771820956be8b190c0088ae3c4efdb53c897
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MYCL SAMD9 ETV5 SERPINB9 CD180	1.67e-04	183	125	5	bd78e5c2670e67b4363078e3ca5a5b7081d24b7e
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MYCL SAMD9 ETV5 SERPINB9 CD180	1.67e-04	183	125	5	d1bf3abf42eb9d7facf775becf1338d1faadd647
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC24A3 ITGA1 PTEN CHST15 EPAS1	1.71e-04	184	125	5	c5436a8e45f471b8d1301abbe9c7879204537f52
ToppCell	Control-Epithelial_alveolar-AT_2-Differentiating_AT2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ETV5 TRIM24 CELSR1 ATP8A1 MYH14	1.75e-04	185	125	5	0d2add28ac1f4fa6de7699be009bf8391badaf4c
ToppCell	PND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ETV5 TEX15 ATP8A1 MYH14 LRP2	1.75e-04	185	125	5	2adb32096aa3473f8d417e5ce9e65264beca9b52
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c3-EREG\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ETV5 PLPP3 NECTIN2 WDFY3 CD180	1.75e-04	185	125	5	7bff05d8d34616adbaa0ea0b69eb30aa906bb9f8
ToppCell	facs-Lung-EPCAM-24m-Epithelial-Alveolar_Epithelial_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ETV5 RNF183 MYH14 NECTIN2 LRP2	1.80e-04	186	125	5	3c4994a1a7db06a61da8170e45e06aaef7896592
ToppCell	facs-Lung-EPCAM-24m-Epithelial-type_II_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ETV5 RNF183 MYH14 NECTIN2 LRP2	1.80e-04	186	125	5	a583d6fc0f1e729f6e9fd18d7b49d6eab9ca32b9
ToppCell	Thalamus-Endothelial\|Thalamus / BrainAtlas - Mouse McCarroll V32	NID2 IL17RC ITGA1 GSTM2 EPAS1	1.80e-04	186	125	5	dcc6e4417c4123d5ca6b96fa8ca4874626aaebdb
ToppCell	E17.5-Epithelial-alveolar_epithelial_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PLB1 ETV5 SERPINB9 ATP8A1 MYH14	1.80e-04	186	125	5	a7a2ef8392a045a62fa4d0983577711d5d397dc4
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ETV5 TRIM24 CELSR1 ATP8A1 MYH14	1.80e-04	186	125	5	e83718fabb057100835d3357df407f283d23fe16
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC3 PRSS51 CELSR1 ZNF804B LRP2	1.80e-04	186	125	5	b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCell	E17.5-Epithelial\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PLB1 ETV5 SERPINB9 ATP8A1 MYH14	1.84e-04	187	125	5	fdabe716ce67f2eede90548198cbe20bbf693570
ToppCell	facs-Heart-LA-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INPP5B SLC24A3 ITGA1 PTEN ZNF804B	1.84e-04	187	125	5	a12f383b02b07af32cc53a154685df8dba8fbd3f
ToppCell	facs-Heart-LA-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INPP5B SLC24A3 ITGA1 PTEN ZNF804B	1.84e-04	187	125	5	c40c152fa14e6afc9188549534b64ccbaded56b3
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TTC28 CELSR1 LRP2 WDFY3 NR1H4	1.84e-04	187	125	5	9d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	ITGA1 ATP8A1 MACF1 KDM6A DYNC1H1	1.89e-04	188	125	5	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	Frontal_cortex-Endothelial\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	NID2 IL17RC ITGA1 GSTM2 EPAS1	1.89e-04	188	125	5	a43392dbd10fc7dbfb31be39b8af8a7ea121c894
ToppCell	10x5'v1-week_12-13-Mesenchymal_osteo-stroma-chondrocyte\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	NID2 ITGA1 MYH14 SCUBE3 ZNF385C	1.89e-04	188	125	5	c9270517e6940e9793586f67f02431210552f278
ToppCell	PND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ETV5 TEX15 ATP8A1 MYH14 LRP2	1.89e-04	188	125	5	7499e353ea5853d06558b20cedee3c7910425d7d
ToppCell	PND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ETV5 TEX15 ATP8A1 MYH14 LRP2	1.89e-04	188	125	5	562f5984efdbbcb8f53ddcee033ccbf9eb678425
ToppCell	Control-Myeloid-MoAM1\|Control / Disease group,lineage and cell class （2021.01.30）	ETV5 CHST15 P2RX7 NECTIN2 CD180	1.94e-04	189	125	5	55d5c2fb9e6ab556d42c83a1e985ee66e4cf9dba
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D231\|Adult / Lineage, Cell type, age group and donor	ETV5 TACC2 ATP8A1 LRP2 MTRR	1.94e-04	189	125	5	dab54a52358f66a8a9460cd6089a06c5fa7e7a5d
ToppCell	BAL-Control-Myeloid-MoAM-MoAM1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ETV5 CHST15 P2RX7 NECTIN2 CD180	1.94e-04	189	125	5	ebb5e069fdca7cf8ffac16a57572e92d2593c86a
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CELSR1 ATP8A1 MYH14 ZNF804B LRP2	1.94e-04	189	125	5	7659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCell	RA-10._Endothelium_II\|RA / Chamber and Cluster_Paper	CYP1B1 ITGA1 ITPR2 PLPP3 EPAS1	1.94e-04	189	125	5	c81787a8c662db5d7814c583dd64562857629e81
ToppCell	BAL-Control-Myeloid-MoAM-MoAM1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ETV5 CHST15 P2RX7 NECTIN2 CD180	1.94e-04	189	125	5	a59e4eaff430a443f9fa7edabe64e66a15b6bffb
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ETV5 TEX15 ATP8A1 MYH14 LRP2	1.98e-04	190	125	5	8ff8c586237cf15f930416710bcff45205fe6f70
ToppCell	droplet-Pancreas-PANCREAS-30m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA1 HOXB7 CHST15 PLPP3 EPAS1	1.98e-04	190	125	5	9d5242759546be0089981ef1877e4ed5f81face5
ToppCell	BAL-Control-Myeloid-MoAM-MoAM1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ETV5 CHST15 P2RX7 NECTIN2 CD180	1.98e-04	190	125	5	5c8aa310886c64ee5dce4ba46a3dd178da549529
ToppCell	NS-critical-d_07-13-Epithelial-FOXN4+\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MYCL ADGRB2 MELTF MBNL3 RAD54L	1.98e-04	190	125	5	7be0f2ff86ca8500a43e0d44e5e292530f9ba0bb
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMTS8 ITGA1 ZYX SLMAP FMN2	1.98e-04	190	125	5	e102622f05c7f3e1bd8b224ea159d57033793ee0
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DCHS2 SLC24A3 ITGA1 ADARB2 CHST15	1.98e-04	190	125	5	2306aa9dbeaef3be8484a5b236605de23cd75d4c
ToppCell	BAL-Control-Myeloid-MoAM-MoAM1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ETV5 CHST15 P2RX7 NECTIN2 CD180	1.98e-04	190	125	5	4b4fe93061c87605dddf5bec94fa07c749c722aa
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DCHS2 SLC24A3 ITGA1 ADARB2 CHST15	1.98e-04	190	125	5	1f83f7f24288a3b9ab33c2e113e845dba96adc8a
ToppCell	PND10-Epithelial-Epithelial_Alveolar\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ETV5 TEX15 ATP8A1 MYH14 LRP2	1.98e-04	190	125	5	dc20d323cee2741e39fba597263d6418ae0eadaf
ToppCell	PND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ETV5 TEX15 ATP8A1 MYH14 LRP2	1.98e-04	190	125	5	ec1bd4929dc82bec2c983a31ece4e3aa82f3a2ab
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DCHS2 SLC24A3 ITGA1 ADARB2 CHST15	2.03e-04	191	125	5	a58c75e9580139fb370b498d95660f10f3a2a27b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RNF183 CELSR1 ZNF804B LRP2 NR1H4	2.03e-04	191	125	5	3c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMTS8 ITGA1 ZYX SLMAP FMN2	2.03e-04	191	125	5	de2cd94ee88a7754f86d39469e38374d668210c7
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal\|E16.5-samps / Age Group, Lineage, Cell class and subclass	ZYX GSTM2 CHST15 PLPP3 MACF1	2.03e-04	191	125	5	3379d145d34f89150f7b06d1340022cfc6b4a6ce
Drug	Arecoline hydrobromide [300-08-3]; Up 200; 17uM; MCF7; HT_HG-U133A	ZNF280A ABCC3 SLC24A3 GRM1 ITPR2 MYH14 WDFY3 BMP15 SOS2	1.48e-06	199	124	9	5423_UP
Drug	triethylammonium chloride	GRM1 GRM5 P2RX7	1.56e-06	5	124	3	CID000011130
Drug	irinotecan HCl; Down 200; 100uM; PC3; HT_HG-U133A	GPHN TACC2 TRIM24 CHST15 PLPP3 ANKRD17 KDM6A SOS2	4.51e-06	171	124	8	7535_DN
Drug	Prenylamine lactate [69-43-2]; Up 200; 9.6uM; MCF7; HT_HG-U133A	CYP1B1 TRAF6 DDX60 SERPINB9 ATP8A1 WDFY3 KDM6A NR1H4	6.32e-06	179	124	8	5489_UP
Drug	Propoxycaine hydrochloride [550-83-4]; Down 200; 12uM; PC3; HT_HG-U133A	ABCC3 NID2 KIAA0232 ATP8A1 SORBS3 KDM6A UTY SOS2	1.06e-05	192	124	8	7155_DN
Drug	0175029-0000 [211245-78-2]; Up 200; 10uM; PC3; HT_HG-U133A	CYP1B1 NID2 GRM5 ITPR2 SORBS3 LRP2 UTY SOS2	1.06e-05	192	124	8	6875_UP
Drug	Gramine [87-52-5]; Up 200; 23uM; MCF7; HT_HG-U133A	CYP1B1 NID2 SAMD9 CASP4 ZNF280B ITPR2 UTY SOS2	1.10e-05	193	124	8	4118_UP
Drug	Dioxybenzone [131-53-3]; Down 200; 16.4uM; HL60; HT_HG-U133A	MYCL CYP1B1 INPP5B REST G6PC3 PKN1 KDM6A SOS2	1.23e-05	196	124	8	3101_DN
Drug	Foliosidine [2520-38-9]; Down 200; 13uM; MCF7; HT_HG-U133A	POLG IL17RC GRM1 LRP2 WDFY3 KDM6A UTY SOS2	1.27e-05	197	124	8	4761_DN
Drug	genistein; Down 200; 10uM; MCF7; HT_HG-U133A_EA	MYCL CYP1B1 ZNF280D TOGARAM1 PLPP3 WDFY3 KDM6A SOS2	1.27e-05	197	124	8	1015_DN
Drug	Panthenol (D) [81-13-0]; Down 200; 19.4uM; HL60; HT_HG-U133A	MYCL CASP4 ETV5 SHOX2 G6PC3 PAM WDFY3 SOS2	1.32e-05	198	124	8	1844_DN
Drug	Aceclofenac [89796-99-6]; Down 200; 11.2uM; PC3; HT_HG-U133A	MYCL NID2 SAMD9 TTC28 INPP5B ETV5 CELSR1 LRP2	1.32e-05	198	124	8	2117_DN
Drug	Methylhydantoin-5-(D) [55147-68-7]; Up 200; 35uM; MCF7; HT_HG-U133A	SAMD9 SHOX2 TEX15 ITPR2 KSR1 ATP8A1 TNN WDFY3	1.37e-05	199	124	8	3333_UP
Drug	xanthanoic acid	GRM1 GRM5	2.94e-05	2	124	2	CID000065736
Drug	AC1L3VCR	STYX MTRR	2.94e-05	2	124	2	CID000122836
Drug	2-methyl-6-styrylpyridine	CYP1B1 GRM1 GRM5	5.49e-05	14	124	3	CID000235382
Drug	Cholic Acid	ABCC3 GSTM2 LRP2 SLC22A20P NR1H4	5.62e-05	75	124	5	ctd:D019826
Drug	HA-966	GPHN GRM1 GRM5 MTRR	5.95e-05	39	124	4	CID000001232
Drug	fenobam	GRM1 GRM5	8.80e-05	3	124	2	CID000162834
Drug	aspirin, USP; Down 200; 100uM; HL60; HT_HG-U133A	CYP1B1 INPP5B PAM KDM6A MBNL3 PSD4 SOS2	8.91e-05	192	124	7	6164_DN
Drug	scriptaid; Down 200; 10uM; PC3; HT_HG-U133A	CYP1B1 LARP1 IL17RC ZYX FZD8 G6PC3 PLPP3	8.91e-05	192	124	7	6919_DN
Drug	Carcinine [56897-53-1]; Down 200; 22uM; PC3; HT_HG-U133A	ADGRB2 TEX15 GRM1 ZYX CELSR1 SORBS3 PSD4	9.20e-05	193	124	7	4225_DN
Drug	Isoxsuprine hydrochloride [579-56-6]; Down 200; 11.8uM; PC3; HT_HG-U133A	IL17RC REST GRM1 ZYX SORBS3 MYH15 SOS2	9.20e-05	193	124	7	4205_DN
Drug	Sulfamethazine sodium salt [1981-58-4]; Up 200; 13.4uM; MCF7; HT_HG-U133A	ZNF280A ABCC3 IL17RC REST P2RX7 LRP2 UTY	9.51e-05	194	124	7	3422_UP
Drug	Tiabendazole [148-79-8]; Down 200; 19.8uM; MCF7; HT_HG-U133A	CYP1B1 TTC28 SLC24A3 G6PC3 WDFY3 UTY MBNL3	9.51e-05	194	124	7	2840_DN
Drug	Medrysone [2668-66-8]; Down 200; 11.6uM; PC3; HT_HG-U133A	CYP1B1 SAMD9 INPP5B ADGRB2 PLPP3 WDFY3 SOS2	9.82e-05	195	124	7	3705_DN
Drug	pioglitazone HCl; Down 200; 10uM; PC3; HT_HG-U133A	ADGRB2 GRM1 ATP8A1 PLPP3 LRP2 EPAS1 SOS2	9.82e-05	195	124	7	5977_DN
Drug	Nefopam hydrochloride [23327-57-3]; Down 200; 13.8uM; MCF7; HT_HG-U133A	MYCL TTC28 REST GRM1 OGDH SORBS3 PSD4	9.82e-05	195	124	7	2317_DN
Drug	Nabumetone [42924-53-8]; Down 200; 17.6uM; MCF7; HT_HG-U133A	CYP1B1 TTC28 SORBS3 UTY MBNL3 PSD4 SOS2	9.82e-05	195	124	7	5428_DN
Drug	Clobetasol propionate [25122-46-7]; Down 200; 8.6uM; PC3; HT_HG-U133A	CYP1B1 ITGA1 FZD8 ATP8A1 PLPP3 SORBS3 PSD4	1.01e-04	196	124	7	4497_DN
Drug	Pepstatin A [26305-03-3]; Down 200; 5.8uM; PC3; HT_HG-U133A	IL17RC REST GRM1 ZYX MYH15 UTY BMP15	1.01e-04	196	124	7	4206_DN
Drug	Felodipine [72509-76-3]; Down 200; 10.4uM; MCF7; HT_HG-U133A	INPP5B ITPR2 HOXB7 MYH14 SORBS3 CPSF1 MACF1	1.01e-04	196	124	7	5294_DN
Drug	Hydralazine hydrochloride [304-20-1]; Down 200; 20.4uM; PC3; HT_HG-U133A	ABCC3 SAMD9 ADGRB2 ATP8A1 MTRR UTY SOS2	1.01e-04	196	124	7	3724_DN
Drug	Khellin [82-02-0]; Down 200; 15.4uM; MCF7; HT_HG-U133A	CYP1B1 SAMD9 TTC28 SHOX2 REST SORBS3 BMP15	1.01e-04	196	124	7	4987_DN
Drug	Meptazinol hydrochloride [59263-76-2]; Down 200; 14.8uM; MCF7; HT_HG-U133A	MYCL SAMD9 LARP1 IL17RC ZYX MACF1 KDM6A	1.05e-04	197	124	7	4774_DN
Drug	Propidium iodide [25535-16-4]; Up 200; 6uM; MCF7; HT_HG-U133A	SAMD9 TTC28 INPP5B REST MELTF SORBS3 LRP2	1.05e-04	197	124	7	6277_UP
Drug	Chlorphensin carbamate [886-74-8]; Up 200; 16.2uM; MCF7; HT_HG-U133A	MYCL TTC28 INPP5B KSR1 MYH14 SORBS3 KDM6A	1.05e-04	197	124	7	7472_UP
Drug	Procainamide hydrochloride [614-39-1]; Up 200; 14.8uM; MCF7; HT_HG-U133A	ABCC3 SAMD9 POLG ADGRB2 CASP4 ZYX SOS2	1.05e-04	197	124	7	2618_UP
Drug	Scopolamine hydrochloride [55-16-3]; Up 200; 11.8uM; MCF7; HT_HG-U133A	SAMD9 INPP5B CASP4 GRM1 ITPR2 CELSR1 MYH14	1.05e-04	197	124	7	3357_UP
Drug	Austricine [10180-88-8]; Up 200; 14.2uM; MCF7; HT_HG-U133A	ZNF280A CASP4 SHOX2 TEX15 MYH14 SORBS3 LRP2	1.05e-04	197	124	7	2812_UP
Drug	fluphenazine dihydrochloride; Up 200; 10uM; HL60; HT_HG-U133A	POLG REST ITPR2 P2RX7 PKN1 CD180 SOS2	1.08e-04	198	124	7	1178_UP
Drug	Oxaprozin [21256-18-8]; Up 200; 13.6uM; MCF7; HT_HG-U133A	MYCL ABCC3 DCHS2 DDX60 ITPR2 MELTF WDFY3	1.08e-04	198	124	7	4352_UP
Drug	Chloroquine diphosphate [50-63-5]; Up 200; 7.8uM; MCF7; HT_HG-U133A	SAMD9 ZNF280D CASP4 SHOX2 ZYX PLPP3 PSD4	1.08e-04	198	124	7	7012_UP
Drug	Catechin-(+,-) hydrate [7295-85-4]; Down 200; 13.8uM; PC3; HT_HG-U133A	ADGRB2 CASP4 KSR1 SORBS3 CPSF1 MYH15 PSD4	1.11e-04	199	124	7	4255_DN
Drug	S(-)Eticlopride hydrochloride [97612-24-3]; Down 200; 10.6uM; PC3; HT_HG-U133A	ABCC3 SAMD9 ITPR2 SORBS3 KDM6A NR1H4 SOS2	1.11e-04	199	124	7	4634_DN
Drug	Theophylline monohydrate [5967-84-0]; Down 200; 20.2uM; PC3; HT_HG-U133A	MYCL ADGRB2 TEX15 GRM1 ZYX SORBS3 SOS2	1.11e-04	199	124	7	4228_DN
Disease	obesity (implicated_via_orthology)	DCHS2 ETV5 ADAMTS8 NMUR2 F2 PNPLA5 ITPR2 GSTM2	2.57e-06	215	118	8	DOID:9970 (implicated_via_orthology)
Disease	Prostatic Neoplasms	MYCL CYP1B1 SAMD9 ETV5 IL17RC ADAMTS8 PTEN MYH14 NECTIN2 LRP2 KDM6A	3.82e-05	616	118	11	C0033578
Disease	Malignant neoplasm of prostate	MYCL CYP1B1 SAMD9 ETV5 IL17RC ADAMTS8 PTEN MYH14 NECTIN2 LRP2 KDM6A	3.82e-05	616	118	11	C0376358
Disease	Kabuki syndrome (implicated_via_orthology)	KDM6A UTY	4.74e-05	3	118	2	DOID:0060473 (implicated_via_orthology)
Disease	Epilepsy, Benign Psychomotor, Childhood	GRM1 GRM5 P2RX7	1.04e-04	23	118	3	C0393672
Disease	Epilepsy, Lateral Temporal	GRM1 GRM5 P2RX7	1.04e-04	23	118	3	C0393682
Disease	Uncinate Epilepsy	GRM1 GRM5 P2RX7	1.04e-04	23	118	3	C0014558
Disease	Epilepsy, Temporal Lobe	GRM1 GRM5 P2RX7	1.04e-04	23	118	3	C0014556
Disease	optic disc size measurement	ADAMTS8 NMUR2 STRIP1 MYPN LRP2 MACF1	1.80e-04	205	118	6	EFO_0004832
Disease	autism spectrum disorder (implicated_via_orthology)	ZNF280A ZNF280D ZNF280B PTEN WDFY3	3.72e-04	152	118	5	DOID:0060041 (implicated_via_orthology)
Disease	primary ovarian insufficiency (is_implicated_in)	POLG BMP15	4.37e-04	8	118	2	DOID:5426 (is_implicated_in)
Disease	Fatty Liver	CYP1B1 PTEN F2 NR1H4	4.37e-04	88	118	4	C0015695
Disease	Steatohepatitis	CYP1B1 PTEN F2 NR1H4	4.37e-04	88	118	4	C2711227
Disease	Seizures, Focal	POLG REST PAM DYNC1H1	8.21e-04	104	118	4	C0751495
Disease	Male sterility	POLG MTRR NR1H4	9.46e-04	48	118	3	C0917731
Disease	Male infertility	POLG MTRR NR1H4	9.46e-04	48	118	3	C0021364
Disease	Subfertility, Male	POLG MTRR NR1H4	9.46e-04	48	118	3	C0848676
Disease	hepatocellular carcinoma (implicated_via_orthology)	POLG PTEN NR1H4	1.00e-03	49	118	3	DOID:684 (implicated_via_orthology)
Disease	restrictive cardiomyopathy (implicated_via_orthology)	MYPN MYH15	1.20e-03	13	118	2	DOID:397 (implicated_via_orthology)
Disease	Paraganglioma	PTEN EPAS1	1.20e-03	13	118	2	C0030421
Disease	Hepatomegaly	CYP1B1 ABCC3 NR1H4	1.33e-03	54	118	3	C0019209
Disease	renal cell carcinoma (biomarker_via_orthology)	PTEN EPAS1	1.40e-03	14	118	2	DOID:4450 (biomarker_via_orthology)
Disease	myelodysplastic syndrome (implicated_via_orthology)	POLG MYBL2	1.61e-03	15	118	2	DOID:0050908 (implicated_via_orthology)
Disease	amino acid measurement	LARP1 TACC2 GRM1 GRM5 ADARB2 RP1L1 LRP2 PKN1 EPAS1	1.64e-03	678	118	9	EFO_0005134
Disease	age-related hearing impairment	NID2 SAMD9 TTC28 ADGRB2 ADARB2 OR4C46	1.97e-03	324	118	6	EFO_0005782
Disease	bilirubin measurement	DCHS2 PKD1L2 GSTM2 MELTF NECTIN2 STEAP1B SOS2	2.05e-03	442	118	7	EFO_0004570
Disease	non-Hodgkin lymphoma (is_implicated_in)	MTRR RAD54L	2.07e-03	17	118	2	DOID:0060060 (is_implicated_in)
Disease	Colorectal Carcinoma	CYP1B1 ABCC3 GRM1 PTEN ADARB2 P2RX7 LRP2 MTRR KDM6A	2.08e-03	702	118	9	C0009402
Disease	coronary artery disease, plasminogen activator inhibitor 1 measurement	PLPP3 TRIM56 NECTIN2	2.08e-03	63	118	3	EFO_0001645, EFO_0004792
Disease	Hypertrophy	PTEN F2	2.33e-03	18	118	2	C0020564
Disease	cataract	PLB1 TTC28 SLC24A3 RHOT1	2.52e-03	141	118	4	MONDO_0005129
Disease	portal hypertension (implicated_via_orthology)	PTEN NR1H4	2.59e-03	19	118	2	DOID:10762 (implicated_via_orthology)
Disease	hemifacial microsomia	NID2 EPAS1	2.59e-03	19	118	2	MONDO_0015398
Disease	response to methotrexate, neurotoxicity	MACF1 PKN1	2.59e-03	19	118	2	EFO_0011057, GO_0031427
Disease	Non-alcoholic Fatty Liver Disease	PTEN F2 NR1H4	2.81e-03	70	118	3	C0400966
Disease	Nonalcoholic Steatohepatitis	PTEN F2 NR1H4	2.81e-03	70	118	3	C3241937
Disease	anti-Mullerian hormone measurement	TTC28 TNN	2.87e-03	20	118	2	EFO_0004769
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	PTEN FMN2 KDM6A EPAS1	3.00e-03	148	118	4	C0279702
Disease	migraine disorder	INPP5B SLC24A3 REST NMUR2 ADARB2 MACF1	3.19e-03	357	118	6	MONDO_0005277
Disease	intellectual disability (implicated_via_orthology)	ZNF280A ZNF280D ZNF280B	3.41e-03	75	118	3	DOID:1059 (implicated_via_orthology)
Disease	Attention Deficit Disorder	GRM1 GRM5	3.48e-03	22	118	2	C0041671
Disease	LEOPARD Syndrome	PTEN SOS2	3.48e-03	22	118	2	C0175704
Disease	Minimal Brain Dysfunction	GRM1 GRM5	3.48e-03	22	118	2	C1321905
Disease	pulse pressure measurement	TTC28 INPP5B SLC24A3 ADAMTS8 ITGA1 PTEN MELTF HOXB7 PLPP3 MYPN OR4C46 STEAP1B SOS2	3.81e-03	1392	118	13	EFO_0005763

Protein segments in the cluster

Peptide	Gene	Start	Entry
CQHCHRQFPTPFQLQ	ZNF280A	336	P59817
RQFPTPFQLQCHIDS	ZNF280A	341	P59817
QHCHRQFPTPFQLQC	ZNF280B	346	Q86YH2
QFPTPFQLQCHIEST	ZNF280D	366	Q6N043
PSPAFHCALCQLQVN	ZNF385C	286	Q66K41
LRFNRQEQVCAHFAP	ADGRB2	81	O60241
LLAENPQSTPQHCFS	EPAS1	551	Q99814
CLAFRNPGPQVADFN	ARL14EPL	41	P0DKL9
ICNTEFDHLPPRNGA	CASP4	141	P49662
QCRQIFGPDFRHCPN	ADAMTS8	451	Q9UP79
DQNHFCQPTDVAVDP	PAM	626	P19021
VVEDPLCNFHSPNFL	AMOTL1	66	Q8IY63
NCVRFPSSNLAIPNH	POLE2	426	P56282
LPEDFPVHNRQFVGC	CELSR1	1606	Q9NYQ6
APAAANFNRQHFSPL	ANKRD17	2361	O75179
NHFDQLCQISAANFP	CD180	331	Q99467
NLQNNHPTAPIICEF	ATP8A1	466	Q9Y2Q0
QPPCLDSSQHEAFIR	RAD54L	61	Q92698
LRSFVQFPNACQAHL	ADARB2	186	Q9NS39
EFFQDVNTCHLPLNP	PIK3C2G	866	O75747
SQECFQFILPALPHA	GPHN	151	Q9NQX3
NLAHTFLQNFCRGNP	ITPR2	1236	Q14571
VHTENPDLTPCFQNS	ABCC3	21	O15438
HQPENPQHFACLLGR	NR1H4	436	Q96RI1
TLPFCGPNQIHQIFC	OR6K3	181	Q8NGY3
ELHVNPRQFNCPVCD	REST	381	Q13127
FSQLLNCPEFVPRQH	LARP1	496	Q6PKG0
GNVNLPHFFCDHRPL	OR1B1	176	Q8NGR6
FTFQLPFCGPNVINH	OR4C15	161	Q8NGM1
HRFQCRLEGFPQENS	GRM5	361	P41594
QLPPAQRNIFLTECH	NMUR2	356	Q9GZQ4
CPFNARHQVPRAEIS	GTSF1	51	Q8WW33
LPQHIPAGCSLQFIF	MTRR	356	Q9UBK8
SQAPAQVHQFPSSCE	G6PC3	91	Q9BUM1
AFFPPLHQFCTNPNN	KDM6A	951	O15550
PENNQCSLHPFQISF	BMP15	286	O95972
RAQELCPENFIHFNN	DDX60	1046	Q8IY21
PVDSFAPFHNVNCPR	CPSF1	971	Q10570
SNTNPSFVRCIVPNH	MYH14	686	Q7Z406
NPFSQVLHVECSFEP	KIAA0232	1046	Q92628
HRQQFIFPVPSAGHC	KSR1	496	Q8IVT5
FFQRICFNTPLAPQA	RHOT1	211	Q8IXI2
IFQLPFCGPNVIDHF	OR4C46	161	A6NHA9
LSPLNFCGPNVINHF	OR3A4P	166	P47883
RNQVFEPSCLDAFPN	GSTM2	166	P28161
AGFQQRALCHALTFP	NSUN5P2	151	Q63ZY6
VFQQQLPLFLERCPH	POLG	406	P54098
CQDFRFQQHSANPPH	MACF1	216	O94854
QRFQRQLSEPCHPFP	ETV5	216	P41161
PSQFNCPNHRCIDLS	LRP2	1151	P98164
NTFCFDNPRGLALHP	LRP2	3316	P98164
SQLAFAVHLPFCGPN	OR4F17	151	Q8NGA8
ENANCRPHIFEDPFS	ITGA1	1026	P56199
CFNHPDFRGQQFILE	CRYGN	51	Q8WXF5
NCTEPALHEFPNDIF	SLC24A3	86	Q9HC58
RQNPHFCTQDAGRPS	PKD1L2	186	Q7Z442
APQAFRIDPHDGQIC	DCHS2	711	Q6V1P9
FPEQTSCAFASNPQR	HOXB7	26	P09629
GPNQVNHFFCDFAPL	OR5P2	166	Q8WZ92
ARFHIPQCDEQGNFL	NID2	956	Q14112
SNSINHFFCDVPPIL	OR5AK2	171	Q8NH90
LNHPNQFFCESQRIL	PRIM2	441	P49643
NCSTPGNFFHVLRRQ	OGDH	831	Q02218
CTFHKTQNPQCPIFR	P2RX7	216	Q99572
QIANCALPCHNPFFS	FZD8	256	Q9H461
ALPCHNPFFSQDERA	FZD8	261	Q9H461
QQRPCHRQPANFSFL	C17orf99	171	Q6UX52
PEDTHIQNAPFQVCF	BBS2	521	Q9BXC9
HHILSQFRACIQPQP	IFNL2	131	Q8IZJ0
CRQQTALHCPFDFPQ	LINC02898	41	Q6ZV80
LHNFHQLSAPQPCFT	PRMT5	506	O14744
PVFNPTVFHCQQALT	MBNL3	281	Q9NUK0
NGQVPCHFEFINKPD	INPP5B	696	P32019
CRNVAQYNANHPDFP	DYNC1H1	2466	Q14204
FVPSFTQNEPSQNCH	CEP57L1	21	Q8IYX8
ILAHQCDFRANPNEP	CYP1B1	486	Q16678
FQCRLPGHLLENPNF	GRM1	376	Q13255
LLPFSDCFREPCNQN	FMN2	571	Q9NZ56
LACHNFLQNFTAAVP	SLC22A20P	31	A6NK97
FLQNFTAAVPPHHCR	SLC22A20P	36	A6NK97
GFFLSDNQHTCIQRP	SCUBE3	141	Q8IX30
ENVQCGHRPAFPNSS	PRSS51	21	A0A1B0GVH4
TNICPFREDPRAHQN	IL17RC	356	Q8NAC3
FNCRVAQYPFEDHNP	PTEN	81	P60484
SQLAFAVHLPFCGPN	OR4F4	151	Q96R69
RDAFFPPLHQFCTNP	UTY	896	O14607
LRPPEHFINCPFNLQ	SOS2	1221	Q07890
PSHHSLRECFRNPQF	RNF183	146	Q96D59
VSQFAACNLAQIPPH	MELTF	611	P08582
PHFLSVCNPDFSQIN	PLPP3	156	O14495
HRFNPNAFICQALAR	SAMD9	1076	Q5K651
STAPHFVRCINPNVN	MYH15	676	Q9Y2K3
FLASHFPNRTDQQCQ	MYBL2	56	P10244
SNVINHFFCDLPPVL	OR5L1	171	Q8NGL2
CPQSTSPNLHELNVF	PNPLA5	196	Q7Z6Z6
QFSRRFHHCNPGIFP	PSD4	661	Q8NDX1
QAPADFAPECFNGRH	POLR1G	46	O15446
AHSNPDFLPVDNCLQ	STRIP1	786	Q5VSL9
PFQQDSHCNVTPLSF	SHOX2	231	O60902
PFLVNLFGCFQTPEH	PKN1	676	Q16512
FAPDCIHPNQKFHSQ	PLB1	996	Q6P1J6
PNVINHFFCDISPVL	OR6B1	171	O95007
QERRFCINPNAGFVH	STYX	151	Q8WUJ0
FDCPSELQHAQELFP	STEAP1B	36	Q6NZ63
IRLPHDCFQNATNSF	CILP	411	O75339
PFLTQDFIHAFQPNA	CHST15	371	Q7LFX5
FLNDRVPNCNVVPHF	UBA3	131	Q8TBC4
ASPVTNNTIQFHCDP	TRIM24	396	O15164
AARPPAVCSHFTQNL	ZNF718	71	Q3SXZ3
QDLPNHPCRFDTNTR	TRIM7	371	Q9C029
NPLIQPVFQGQDFCH	ZNF804B	1311	A4D1E1
INRDACHFPGFPVLQ	WDFY3	1746	Q8IZQ1
QHNYAARFPPESCSQ	MYCL	211	P12524
QDNPSHNVFCSPVSI	SERPINB9	21	P50453
RNAQAPSHRECFLPS	RP1L1	6	Q8IWN7
GARFPHPSDCSQVQQ	TNN	1061	Q9UQP3
AIFTCRPNSHPFQER	SLMAP	6	Q14BN4
DCPQCQRPFQKFHIN	TRAF6	161	Q9Y4K3
LNFQFHDPAPRTVCN	SORBS3	46	O60504
QPRGPACDASRQEFH	TACC2	761	O95359
QENRNTCFSPDHKQP	TTC28	2071	Q96AY4
SFIVDQANRPHCVPD	ZYX	481	Q15942
THPGADLQENFCRNP	F2	146	P00734
NLFQNSRDFNPDCLP	TOGARAM1	716	Q9Y4F4
FCNQEHPESQLPVSS	TEX15	1126	Q9BXT5
PSLCEFVFHNNPLVA	XRRA1	396	Q6P2D8
AAQCPQHPGEALRFL	TRIM56	166	Q9BRZ2
KHSPNLSFEPNFCQD	MYPN	106	Q86TC9
QRPDAPANHQNVAAF	NECTIN2	71	Q92692