Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calmodulin binding	AKAP5 MYO7A OBSCN KCNH1 SCN3A MYO1F TRPV4 NOS1 KCNH5	1.29e-04	230	165	9	GO:0005516
GeneOntologyMolecularFunction	retinoic acid 4-hydroxylase activity	CYP2C19 CYP2C8 CYP2C18	1.89e-04	14	165	3	GO:0008401
GeneOntologyMolecularFunction	NAD+ nucleotidase, cyclic ADP-ribose generating	TLR6 TLR1 TLR4	2.87e-04	16	165	3	GO:0061809
GeneOntologyMolecularFunction	monooxygenase activity	CYP2C19 CYP2C8 CYP2C18 PAM CYP4F22 NOS1	3.89e-04	115	165	6	GO:0004497
GeneOntologyMolecularFunction	Toll-like receptor 2 binding	TLR6 TLR1	4.03e-04	4	165	2	GO:0035663
GeneOntologyMolecularFunction	linoleic acid epoxygenase activity	CYP2C19 CYP2C18	4.03e-04	4	165	2	GO:0071614
GeneOntologyMolecularFunction	cytoskeletal motor activity	KIF23 MYO7A MYO3B MYO1F DYNC1H1 DNAH11	4.47e-04	118	165	6	GO:0003774
GeneOntologyMolecularFunction	ATP-dependent activity	KIF23 RTEL1 MYO7A ACSS1 RNF213 ABCA6 CHD5 MYO3B AFG3L2 MYO1F ERCC6L2 TOR1B DYNC1H1 DNAH11	5.93e-04	614	165	14	GO:0140657
Domain	Toll-like_receptor	TLR6 TLR1 TLR4	6.81e-06	5	166	3	IPR017241
Domain	IQ	MYO7A OBSCN MYO3B SCN3A MYO1F SCN10A	4.00e-05	71	166	6	PF00612
Domain	K_chnl_volt-dep_EAG	KCNH1 KCNH5	7.85e-05	2	166	2	IPR003949
Domain	IQ_motif_EF-hand-BS	MYO7A OBSCN MYO3B SCN3A MYO1F SCN10A	1.51e-04	90	166	6	IPR000048
Domain	IQ	MYO7A OBSCN MYO3B SCN3A MYO1F SCN10A	1.81e-04	93	166	6	PS50096
Domain	MPI_Phosphatase	CDC25A CDC25B	2.34e-04	3	166	2	IPR000751
Domain	M-inducer_phosp	CDC25A CDC25B	2.34e-04	3	166	2	PF06617
Domain	Zinc_finger_PHD-type_CS	ZMYND11 KDM5A DIDO1 NSD3 CHD5	2.80e-04	65	166	5	IPR019786
Domain	-	GTF2IRD2B GTF2IRD2	4.66e-04	4	166	2	3.90.1460.10
Domain	FAM47	FAM47C FAM47B	4.66e-04	4	166	2	PF14642
Domain	GTF2I	GTF2IRD2B GTF2IRD2	4.66e-04	4	166	2	PS51139
Domain	GTF2I	GTF2IRD2B GTF2IRD2	4.66e-04	4	166	2	PF02946
Domain	FAM47	FAM47C FAM47B	4.66e-04	4	166	2	IPR032743
Domain	GTF2I	GTF2IRD2B GTF2IRD2	4.66e-04	4	166	2	IPR004212
Domain	Ion_trans_dom	KCNH1 SCN3A SCN10A TRPV4 CACNA1I KCNH5	5.44e-04	114	166	6	IPR005821
Domain	Ion_trans	KCNH1 SCN3A SCN10A TRPV4 CACNA1I KCNH5	5.44e-04	114	166	6	PF00520
Domain	PHD	ZMYND11 KDM5A DIDO1 NSD3 CHD5	5.46e-04	75	166	5	PF00628
Domain	Cyt_P450_E_grp-I	CYP2C19 CYP2C8 CYP2C18 CYP4F22	6.75e-04	45	166	4	IPR002401
Domain	Znf_PHD-finger	ZMYND11 KDM5A DIDO1 NSD3 CHD5	6.93e-04	79	166	5	IPR019787
Domain	WSC	WSCD1 PKD1	7.72e-04	5	166	2	SM00321
Domain	WSC	WSCD1 PKD1	7.72e-04	5	166	2	PS51212
Domain	WSC_carb-bd	WSCD1 PKD1	7.72e-04	5	166	2	IPR002889
Domain	WSC	WSCD1 PKD1	7.72e-04	5	166	2	PF01822
Domain	IQ	MYO7A OBSCN MYO3B SCN3A MYO1F	7.76e-04	81	166	5	SM00015
Domain	TIR	TLR6 TLR1 TLR4	8.15e-04	21	166	3	SM00255
Domain	TIR	TLR6 TLR1 TLR4	9.38e-04	22	166	3	PF01582
Domain	-	TLR6 TLR1 TLR4	1.07e-03	23	166	3	3.40.50.10140
Domain	PHD	ZMYND11 KDM5A DIDO1 NSD3 CHD5	1.19e-03	89	166	5	SM00249
Domain	TIR	TLR6 TLR1 TLR4	1.22e-03	24	166	3	PS50104
Domain	Cys-rich_flank_reg_C	TLR6 PXDN TLR1 TLR4 PKD1	1.25e-03	90	166	5	IPR000483
Domain	LRRCT	TLR6 PXDN TLR1 TLR4 PKD1	1.25e-03	90	166	5	SM00082
Domain	Cyt_P450_CS	CYP2C19 CYP2C8 CYP2C18 CYP4F22	1.26e-03	53	166	4	IPR017972
Domain	Znf_PHD	ZMYND11 KDM5A DIDO1 NSD3 CHD5	1.31e-03	91	166	5	IPR001965
Domain	TIR_dom	TLR6 TLR1 TLR4	1.37e-03	25	166	3	IPR000157
Domain	ZF_PHD_2	ZMYND11 KDM5A DIDO1 NSD3 CHD5	1.59e-03	95	166	5	PS50016
Domain	RBD	RGS12 TIAM2	1.60e-03	7	166	2	SM00455
Domain	RBD_dom	RGS12 TIAM2	1.60e-03	7	166	2	IPR003116
Domain	RBD	RGS12 TIAM2	1.60e-03	7	166	2	PS50898
Domain	CYTOCHROME_P450	CYP2C19 CYP2C8 CYP2C18 CYP4F22	1.65e-03	57	166	4	PS00086
Domain	ZF_PHD_1	ZMYND11 KDM5A DIDO1 NSD3 CHD5	1.66e-03	96	166	5	PS01359
Domain	-	CYP2C19 CYP2C8 CYP2C18 CYP4F22	1.76e-03	58	166	4	1.10.630.10
Domain	p450	CYP2C19 CYP2C8 CYP2C18 CYP4F22	1.76e-03	58	166	4	PF00067
Domain	AAA	RNF213 ABCA6 AFG3L2 TOR1B DYNC1H1 DNAH11	1.83e-03	144	166	6	SM00382
Domain	AAA+_ATPase	RNF213 ABCA6 AFG3L2 TOR1B DYNC1H1 DNAH11	1.83e-03	144	166	6	IPR003593
Pubmed	TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation.	TLR6 TLR1 TLR4	1.19e-07	3	172	3	16461792
Pubmed	Toll-like receptors.	TLR6 TLR1 TLR4 SLC14A2	1.86e-07	11	172	4	18394314
Pubmed	Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.	CYP2C19 CYP2C8 CYP2C18	4.74e-07	4	172	3	19706858
Pubmed	A recombinant lipoprotein containing an unsaturated fatty acid activates NF-kappaB through the TLR2 signaling pathway and induces a differential gene profile from a synthetic lipopeptide.	TLR6 TLR1 TLR4	4.74e-07	4	172	3	20478617
Pubmed	Biochemistry and molecular biology of the human CYP2C subfamily.	CYP2C19 CYP2C8 CYP2C18	4.74e-07	4	172	3	7704034
Pubmed	Toll-like receptor 2 is required for inflammatory responses to Francisella tularensis LVS.	TLR6 TLR1 TLR4	4.74e-07	4	172	3	16622218
Pubmed	Association of Toll-like receptor polymorphisms with HIV status in North Americans.	TLR6 TLR1 TLR4	4.74e-07	4	172	3	25253287
Pubmed	Structural basis for signal transduction by the Toll/interleukin-1 receptor domains.	TLR6 TLR1 TLR4	4.74e-07	4	172	3	11081518
Pubmed	Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.	CYP2C19 CYP2C8 CYP2C18	4.74e-07	4	172	3	2009263
Pubmed	Genetic variation in the CYP2C monooxygenase enzyme subfamily shows no association with longevity in a German population.	CYP2C19 CYP2C8 CYP2C18	4.74e-07	4	172	3	21798861
Pubmed	Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study.	CYP2C19 CYP2C8 CYP2C18	4.74e-07	4	172	3	23755828
Pubmed	Association between toll-like receptors/CD14 gene polymorphisms and inflammatory bowel disease in Korean population.	TLR6 TLR1 TLR4	1.18e-06	5	172	3	22219617
Pubmed	TLR-dependent control of Francisella tularensis infection and host inflammatory responses.	TLR6 TLR1 TLR4	1.18e-06	5	172	3	19936231
Pubmed	Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans.	TLR6 TLR1 TLR4	1.18e-06	5	172	3	19771452
Pubmed	Abnormal high-density lipoprotein induces endothelial dysfunction via activation of Toll-like receptor-2.	TLR6 TLR1 TLR4	1.18e-06	5	172	3	23477738
Pubmed	A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphoma.	TLR6 TLR1 TLR4	1.18e-06	5	172	3	19029192
Pubmed	Respiratory syncytial virus activates innate immunity through Toll-like receptor 2.	TLR6 TLR1 TLR4	1.18e-06	5	172	3	19019963
Pubmed	Toll-like receptor gene polymorphisms confer susceptibility to graft-versus-host disease in allogenic hematopoietic stem cell transplantation.	TLR6 TLR1 TLR4	1.18e-06	5	172	3	22703024
Pubmed	Role of TLR2-dependent IL-10 production in the inhibition of the initial IFN-γ T cell response to Porphyromonas gingivalis.	TLR6 TLR1 TLR4	1.18e-06	5	172	3	23077245
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ZMYND11 KIF23 DEAF1 KDM5A DIDO1 XPC MYSM1 NSD3 PAPOLG ORC5 GTF3C2 CHD5 NIPBL SENP7	2.26e-06	608	172	14	36089195
Pubmed	Role for MyD88, TLR2 and TLR9 but not TLR1, TLR4 or TLR6 in experimental autoimmune encephalomyelitis.	TLR6 TLR1 TLR4	2.35e-06	6	172	3	21685327
Pubmed	Toll-like receptor and TIRAP gene polymorphisms in pulmonary tuberculosis patients of South India.	TLR6 TLR1 TLR4	2.35e-06	6	172	3	20797905
Pubmed	Structural and functional understanding of the toll-like receptors.	TLR6 TLR1 TLR4	2.35e-06	6	172	3	33576548
Pubmed	Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection.	TLR6 TLR1 TLR4	2.35e-06	6	172	3	17004992
Pubmed	Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.	TLR6 TLR1 TLR4	2.35e-06	6	172	3	10426995
Pubmed	Isolated Toll-like receptor transmembrane domains are capable of oligomerization.	TLR6 TLR1 TLR4	4.10e-06	7	172	3	23155421
Pubmed	Mutations in pattern recognition receptor genes modulate seroreactivity to microbial antigens in patients with inflammatory bowel disease.	TLR6 TLR1 TLR4	4.10e-06	7	172	3	17595233
Pubmed	Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.	TLR6 TLR1 TLR4	6.54e-06	8	172	3	11561001
Pubmed	Gene polymorphisms of Toll-like and related recognition receptors in relation to the vaginal carriage of Gardnerella vaginalis and Atopobium vaginae.	TLR6 TLR1 TLR4	9.77e-06	9	172	3	19200604
Pubmed	Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women.	TLR6 TLR1 TLR4	9.77e-06	9	172	3	19543401
Pubmed	Regulation of angiogenesis, mural cell recruitment and adventitial macrophage behavior by Toll-like receptors.	TLR6 TLR1 TLR4	9.77e-06	9	172	3	24091496
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SETD1A SHROOM3 UBE4B MYO7A NTSR1 OBSCN FRYL TIAM2 ARHGEF10L NSD3 FAM20C CHD5 PKD1 TIGD3 DTX2 LRBA MCF2L DYNC1H1	1.03e-05	1105	172	18	35748872
Pubmed	Polymorphisms in innate immunity genes associated with development of bronchiolitis obliterans after lung transplantation.	TLR6 TLR1 TLR4	1.39e-05	10	172	3	20227302
Pubmed	[Expression of toll-like receptors in human epidermal keratinocytes].	TLR6 TLR1 TLR4	1.39e-05	10	172	3	18686608
Pubmed	Toll-like receptors.	TLR6 TLR1 TLR4	1.39e-05	10	172	3	11782555
Pubmed	Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis.	TLR6 TLR1 TLR4	1.39e-05	10	172	3	19122641
Pubmed	A family of human receptors structurally related to Drosophila Toll.	TLR6 TLR1 TLR4	1.39e-05	10	172	3	9435236
Pubmed	Phosphatidylinositol 3-kinase activation attenuates the TLR2-mediated macrophage proinflammatory cytokine response to Francisella tularensis live vaccine strain.	TLR6 TLR1 TLR4	1.39e-05	10	172	3	21098227
Pubmed	Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.	FLT1 CADM4 OBSCN PTGFRN CNTN6 VSTM4 PXDN	1.71e-05	162	172	7	25826454
Pubmed	Identification of a key pathway required for the sterile inflammatory response triggered by dying cells.	TLR6 TLR1 TLR4	1.90e-05	11	172	3	17572686
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	SHROOM3 MYO7A TOPAZ1 TMC4 XPC AFG3L2 SCN10A	2.17e-05	168	172	7	30631154
Pubmed	Species-specific recognition of Aspergillus fumigatus by Toll-like receptor 1 and Toll-like receptor 6.	TLR6 TLR1	2.43e-05	2	172	2	22315281
Pubmed	[DISTRIBUTION OF TWO-LOCUS HAPLOTYPES OF MICROBIAL COMPONENT SENSOR GENES TLR1 AND TLR6 IN MAJOR POPULATIONS OF SOUTH URALS].	TLR6 TLR1	2.43e-05	2	172	2	26470427
Pubmed	Independent mechanistic inhibition of cdc25 phosphatases by a natural product caulibugulone.	CDC25A CDC25B	2.43e-05	2	172	2	17018577
Pubmed	Brain-derived neurotrophic factor fails to arrest neuromuscular disorders in the paralysé mouse mutant, a model of motoneuron disease.	BDNF AFG3L2	2.43e-05	2	172	2	9455973
Pubmed	L-Selectin Enhanced T Cells Improve the Efficacy of Cancer Immunotherapy.	SELL FOXP3	2.43e-05	2	172	2	31249570
Pubmed	Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants.	TLR6 TLR1	2.43e-05	2	172	2	21852947
Pubmed	The contribution of CYP2C gene subfamily involved in epoxygenase pathway of arachidonic acids metabolism to hypertension susceptibility in Russian population.	CYP2C19 CYP2C8	2.43e-05	2	172	2	28513222
Pubmed	Toll-like receptor 4 is necessary for glucose-dependent glucagon-like peptide-1 secretion in male mice.	GCG TLR4	2.43e-05	2	172	2	30661789
Pubmed	Genetic ancestry effects on the distribution of toll-like receptors (TLRs) gene polymorphisms in a population of the Atlantic Forest, São Paulo, Brazil.	TLR6 TLR1	2.43e-05	2	172	2	29175392
Pubmed	Toll-like receptor 1 inhibits Toll-like receptor 4 signaling in endothelial cells.	TLR1 TLR4	2.43e-05	2	172	2	11932926
Pubmed	The Roles of TLR Gene Polymorphisms in Atherosclerosis: A Systematic Review and Meta-Analysis of 35,317 Subjects.	TLR6 TLR1	2.43e-05	2	172	2	28474755
Pubmed	Significant Association between Toll-Like Receptor Gene Polymorphisms and Posttransplantation Diabetes Mellitus.	TLR6 TLR4	2.43e-05	2	172	2	27486667
Pubmed	TLR4 Signaling Selectively and Directly Promotes CGRP Release from Vagal Afferents in the Mouse.	TLR4 SCN10A	2.43e-05	2	172	2	33318075
Pubmed	The Transcription Factor Foxp3 Shapes Regulatory T Cell Identity by Tuning the Activity of trans-Acting Intermediaries.	TCF7 FOXP3	2.43e-05	2	172	2	33176163
Pubmed	Rad4 regulates protein turnover at a postubiquitylation step.	UBE4B XPC	2.43e-05	2	172	2	19889839
Pubmed	Recruitment of memory B cells to lymph nodes remote from the site of immunization requires an inflammatory stimulus.	SELL TLR4	2.43e-05	2	172	2	22675203
Pubmed	Multi-ethnic distribution of clinically relevant CYP2C genotypes and haplotypes.	CYP2C19 CYP2C8	2.43e-05	2	172	2	22491019
Pubmed	TRPV4 Mediates Acute Bladder Responses to Bacterial Lipopolysaccharides.	TLR4 TRPV4	2.43e-05	2	172	2	32435246
Pubmed	Variants in toll-like receptor 1 and 4 genes are associated with Chlamydia trachomatis among women with pelvic inflammatory disease.	TLR1 TLR4	2.43e-05	2	172	2	22238472
Pubmed	Biochemical and Functional Characterization of RNF213 (Mysterin) R4810K, a Susceptibility Mutation of Moyamoya Disease, in Angiogenesis In Vitro and In Vivo.	RNF213 RNF123	2.43e-05	2	172	2	26126547
Pubmed	Foxp3 exhibits antiepileptic effects in ictogenesis involved in TLR4 signaling.	TLR4 FOXP3	2.43e-05	2	172	2	28386044
Pubmed	Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans.	CYP2C19 CYP2C18	2.43e-05	2	172	2	8110777
Pubmed	AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension.	AKAP5 TRPV4	2.43e-05	2	172	2	25005230
Pubmed	Host resistance to infection: genetic control of lipopolysaccharide responsiveness by TOLL-like receptor genes.	TLR1 TLR4	2.43e-05	2	172	2	10431187
Pubmed	Chromosome mapping of human CDC25A and CDC25B phosphatases.	CDC25A CDC25B	2.43e-05	2	172	2	8276402
Pubmed	Comparison of TFII-I gene family members deleted in Williams-Beuren syndrome.	GTF2IRD2B GTF2IRD2	2.43e-05	2	172	2	15388857
Pubmed	Regional localization of the human c-ros-1 on 6q22 and flt on 13q12.	FLT1 ROS1	2.43e-05	2	172	2	3115921
Pubmed	Dysregulation of Rnf 213 gene contributes to T cell response via antigen uptake, processing, and presentation.	RNF213 RNF123	2.43e-05	2	172	2	33973242
Pubmed	A Novel CYP2C-Haplotype Associated With Ultrarapid Metabolism of Escitalopram.	CYP2C19 CYP2C18	2.43e-05	2	172	2	33759177
Pubmed	Nicotine exaggerates LPS-induced airway hyperreactivity via JNK-mediated up-regulation of Toll-like receptor 4.	TLR6 TLR4	2.43e-05	2	172	2	24669857
Pubmed	Genetic association study of polymorphisms FOXP3 and FCRL3 in women with endometriosis.	FCRL3 FOXP3	2.43e-05	2	172	2	22341374
Pubmed	FOXP3 and TLR4 protein expression are correlated in non-small cell lung cancer: implications for tumor progression and escape.	TLR4 FOXP3	2.43e-05	2	172	2	22749378
Pubmed	Peripheral insulin resistance in ILK-depleted mice by reduction of GLUT4 expression.	ILK SLC2A4	2.43e-05	2	172	2	28490443
Pubmed	CDC25A phosphatase controls meiosis I progression in mouse oocytes.	CDC25A CDC25B	2.43e-05	2	172	2	18367163
Pubmed	A view of response and resistance to atomoxetine treatment in children with ADHD: effects of CYP2C19 polymorphisms and BDNF levels.	CYP2C19 BDNF	2.43e-05	2	172	2	35486119
Pubmed	Sequence variants in the TLR4 and TLR6-1-10 genes and prostate cancer risk. Results based on pooled analysis from three independent studies.	TLR6 TLR4	2.43e-05	2	172	2	20200442
Pubmed	Few alterations in clinical pathology and histopathology observed in a CYP2C18&19 humanized mice model.	CYP2C19 CYP2C18	2.43e-05	2	172	2	19038035
Pubmed	Functional distinction of human EAG1 and EAG2 potassium channels.	KCNH1 KCNH5	2.43e-05	2	172	2	11943152
Pubmed	Transcription Factor 7 Limits Regulatory T Cell Generation in the Thymus.	TCF7 FOXP3	2.43e-05	2	172	2	26324778
Pubmed	Expression of CDC25A and CDC25B phosphatase proteins in human retinoblastoma and its correlation with clinicopathological parameters.	CDC25A CDC25B	2.43e-05	2	172	2	25326518
Pubmed	Expression of Toll-like receptors on peripheral blood white cells in acute otitis media.	TLR1 TLR4	2.43e-05	2	172	2	24629739
Pubmed	Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin.	TLR6 TLR1	2.43e-05	2	172	2	11123271
Pubmed	Linkage disequilibrium between the CYP2C1917 and CYP2C82 alleles in populations of African descent.	CYP2C19 CYP2C8	2.43e-05	2	172	2	20890775
Pubmed	CDC25 phosphatases as potential human oncogenes.	CDC25A CDC25B	2.43e-05	2	172	2	7667636
Pubmed	Expression of Foxp3 and TLR4 in human papillary thyroid carcinoma and its clinical significance.	TLR4 FOXP3	2.43e-05	2	172	2	36165427
Pubmed	Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs.	CYP2C8 CYP2C18	2.43e-05	2	172	2	10487415
Pubmed	The gut microbiota reduces leptin sensitivity and the expression of the obesity-suppressing neuropeptides proglucagon (Gcg) and brain-derived neurotrophic factor (Bdnf) in the central nervous system.	GCG BDNF	2.43e-05	2	172	2	23892476
Pubmed	BDNF Val66Met polymorphism alters food intake and hypothalamic BDNF expression in mice.	BDNF SLC2A4	2.43e-05	2	172	2	32430940
Pubmed	Local Peroxynitrite Impairs Endothelial Transient Receptor Potential Vanilloid 4 Channels and Elevates Blood Pressure in Obesity.	AKAP5 TRPV4	2.43e-05	2	172	2	32008372
Pubmed	Cdc25A and cdc25B expression in malignant lymphoma of the thyroid: correlation with histological subtypes and cell proliferation.	CDC25A CDC25B	2.43e-05	2	172	2	14767575
Pubmed	Role of TLR1 and TLR6 in the host defense against disseminated candidiasis.	TLR6 TLR1	2.43e-05	2	172	2	18036178
Pubmed	The association of genetic variants in toll-like receptor 2 subfamily with allergy and asthma after hospitalization for bronchiolitis in infancy.	TLR6 TLR1	2.43e-05	2	172	2	24445834
Pubmed	Nociceptor-derived brain-derived neurotrophic factor regulates acute and inflammatory but not neuropathic pain.	BDNF SCN10A	2.43e-05	2	172	2	16413788
Pubmed	Toll-like Receptor 1 743 A>G, 1805 T>G & Toll-like Receptor 6 745 C>T gene polymorphism and tuberculosis: a case control study of north Indian population from Agra (India).	TLR6 TLR1	2.43e-05	2	172	2	24984237
Pubmed	RSK promotes G2/M transition through activating phosphorylation of Cdc25A and Cdc25B.	CDC25A CDC25B	2.43e-05	2	172	2	23708659
Pubmed	The expression of Foxp3 and TLR4 in cervical cancer: association with immune escape and clinical pathology.	TLR4 FOXP3	2.43e-05	2	172	2	28013346
Pubmed	SNPs in the exons of Toll-like receptors are associated with susceptibility to type 1 diabetes in Chinese population.	TLR6 TLR1	2.43e-05	2	172	2	25261617
Pubmed	5'-AMP-activated protein kinase regulates skeletal muscle glycogen content and ergogenics.	SLC2A4 PRKAG3	2.43e-05	2	172	2	15857891
Pubmed	Roles of surface residues of intracellular domains of heag potassium channels.	KCNH1 KCNH5	2.43e-05	2	172	2	19172261
GeneFamily	CD molecules\|Toll like receptors	TLR6 TLR1 TLR4	3.23e-05	10	119	3	948
GeneFamily	Class III Cys-based CDC25 phosphatases	CDC25A CDC25B	1.28e-04	3	119	2	713
GeneFamily	PHD finger proteins	ZMYND11 KDM5A DIDO1 NSD3 CHD5	3.19e-04	90	119	5	88
GeneFamily	Neuroblastoma breakpoint family	NBPF4 NBPF6 NBPF5P	4.47e-04	23	119	3	662
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	OBSCN TIAM2 ARHGEF10L MCF2L	9.39e-04	66	119	4	722
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN3A SCN10A	1.50e-03	9	119	2	1203
GeneFamily	Cytochrome P450 family 2	CYP2C19 CYP2C8 CYP2C18	1.56e-03	35	119	3	1001
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	WSCD1 FLT1 RUNDC3B DGKE TMEM255B FZD6 MCTP1 CLEC14A	5.63e-07	182	172	8	0346f81bbb1f309f3e9d063b20547d548d09472c
ToppCell	Bronchus_Control_(B.)-Stromal-TX-Fibroblasts-1\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	PTH1R VSTM4 ABCA6 NOTUM CLEC14A C11orf96 MYO3B SLC22A31	1.14e-06	200	172	8	16a3685c41194a0a4a772e4eee372160263480e0
ToppCell	Bronchial-NucSeq-Endothelial-Endothelia_vascular-VE_systemic_arterial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	WSCD1 FLT1 RUNDC3B GLA CLEC14A NOS1 DMTN	3.55e-06	164	172	7	3cd80e6275f0f9b5667912139d15ebf5e6b17f2f
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid-neutrophil\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELL USP49 TOPAZ1 GCG TMC4 MCTP1 USP32	3.55e-06	164	172	7	8e6dbddacd56a07769163813e3ebfad13302bb62
ToppCell	Endothelial-endothelial_cell_of_bronchial_vessel\|World / Lineage, Cell type, age group and donor	WSCD1 FLT1 RUNDC3B DGKE GCG CLEC14A MCF2L	3.69e-06	165	172	7	84e553d699ac56df89a77248f7308b9133e1b683
ToppCell	droplet-Liver-Npc-18m-Myeloid-plasmacytoid_dendritic_cells\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELL PPFIA4 OBSCN GCG CHD5 ERMAP C4orf46	4.00e-06	167	172	7	a66552667aa6e8992c159df27a57c2e8ae14a9ce
ToppCell	droplet-Liver-Npc-18m-Myeloid-plasmacytoid_dendritic_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELL PPFIA4 OBSCN GCG CHD5 ERMAP C4orf46	4.00e-06	167	172	7	1248f809afbcccb42ce9e29cfe6fa1f6f6b65005
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL22A1 ADAM28 CNTN6 MYO3B SCN3A UNC79 DNAH11	4.32e-06	169	172	7	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TRADD SHROOM3 PTH1R ORC5 FAM20C OSGIN2 C4orf46	4.50e-06	170	172	7	b1a16600754e0c12f7d39c9221f1b03135833f16
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HTR1F COL22A1 PTCHD4 PTGFRN KCNH1 ROS1 KCNH5	5.04e-06	173	172	7	8335b77f730ed43fc348a005566e73a103c6774b
ToppCell	facs-Heart-RV-24m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC2A4 VSTM4 PIANP KCNH1 C11orf96 SCN3A ADAMTS17	5.44e-06	175	172	7	bfac175b79bb7d3d81074a2407c206a7647ee75d
ToppCell	facs-Heart-RV-24m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC2A4 VSTM4 PIANP KCNH1 C11orf96 SCN3A ADAMTS17	5.44e-06	175	172	7	c94fb35bbac95123201ca87ca835aecaefc0c490
ToppCell	Control-Epithelial_alveolar-AT_1-AT1-AT2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM3 GRB7 CNTN6 MYO3B ST6GALNAC5 IRX2 SLC22A31	7.03e-06	182	172	7	a95956ce4adccb34cc0c47ebfa1878ce4617904e
ToppCell	PBMC-Mild-cDC_9\|Mild / Compartment, Disease Groups and Clusters	FLT1 RNF213 TMEM255B SLC2A4 ABCA6 TLR4 CFAP74	7.55e-06	184	172	7	2e0c9a2c40c892a2d435eafb31f1f838de9baf15
ToppCell	10x5'-blood-Lymphocytic_T_CD4-Tregs\|blood / Manually curated celltypes from each tissue	SELL CCDC141 OGDH NSD3 FCRL3 CDC25B FOXP3	7.55e-06	184	172	7	22c15ce30171c687ab564f4383ae74d38b759272
ToppCell	COPD-Lymphoid-T_Regulatory\|COPD / Disease state, Lineage and Cell class	DGKE CCDC141 NSD3 FCRL3 PAM LRBA FOXP3	7.82e-06	185	172	7	846403edd4c8f646201d519055198fc38b7ffff9
ToppCell	droplet-Lung-3m-Endothelial-venous_endothelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	WSCD1 FLT1 TMEM255B FZD6 KCNH1 CLEC14A TRPV4	8.39e-06	187	172	7	ebe4d1216cc0d4c079b413d5a5460cfd3a4af922
ToppCell	droplet-Lung-3m-Endothelial-venous_endothelial-vein_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	WSCD1 FLT1 TMEM255B FZD6 KCNH1 CLEC14A TRPV4	8.39e-06	187	172	7	3827fa80e558b642f3e0036f5ee1a8b69f437e30
ToppCell	droplet-Lung-3m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	WSCD1 FLT1 TMEM255B FZD6 KCNH1 CLEC14A TRPV4	8.39e-06	187	172	7	1bf696eb03422ea507d3efe58dda1d442a65225d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GRB7 ABCA6 MYO3B SCN3A ADAMTS17 NOS1 VCL	8.39e-06	187	172	7	77886f99c229610abd28c4c370d2c7d1536c9782
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	WSCD1 FLT1 RUNDC3B MCTP1 CLEC14A MCF2L CDC25B	8.69e-06	188	172	7	789d1be574e693d7bdd488f3c72c6df788e47b47
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC141 BDNF SLC2A4 VSTM4 C11orf96 SCN3A VCL	9.31e-06	190	172	7	1ab3f19f1ce9f58e5125135704d94655a2e330a0
ToppCell	T_cells-Central_memory_CD4+_T_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	SELL TRADD TCF7 MGAT4A RPS9 PIANP CACNA1I	9.63e-06	191	172	7	25dd538d6a361bd3367c8a1c0dfc9e7003061af3
ToppCell	PCW_07-8.5-Endothelial-Endothelial_mature-endo_venous_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SELL WSCD1 FLT1 MGAT4A TMEM255B FZD6 CLEC14A	9.63e-06	191	172	7	54029b68fb78163c969890886ab0f8fb0dcf3c20
ToppCell	droplet-Bladder-nan-3m-Endothelial-endothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 CCDC141 TMEM255B SLC2A4 C11orf96 SCN3A MCF2L	1.03e-05	193	172	7	19dfc4a2c91fcea4f5991e7c44df46faeecb06b8
ToppCell	droplet-Bladder-nan-3m-Endothelial\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 CCDC141 TMEM255B SLC2A4 C11orf96 SCN3A MCF2L	1.03e-05	193	172	7	351e0acd411a9eb0dbc0e358d0d1e3759753fa40
ToppCell	droplet-Bladder-nan-3m-Endothelial-endothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 CCDC141 TMEM255B SLC2A4 C11orf96 SCN3A MCF2L	1.03e-05	193	172	7	8be24713f8ba2545b7647d1994e9e993623ddaa3
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SHROOM3 FAM20C MYO3B SCN3A TRPV4 LRBA SLC14A2	1.07e-05	194	172	7	04bfc555743f7d8821439d05ae442d15e9886c59
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SHROOM3 FAM20C MYO3B SCN3A TRPV4 LRBA SLC14A2	1.07e-05	194	172	7	69bff17df4a760ccf081cf52ff04af02c14f448d
ToppCell	RV-09._Endothelium_I\|RV / Chamber and Cluster_Paper	FLT1 RUNDC3B DGKE FRYL MCTP1 CLEC14A MCF2L	1.07e-05	194	172	7	7b408096e717f2327c12aea35a8d5fc4621d3b06
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SHROOM3 PPFIA4 PRKAG3 MMP25 TLR4 SCN10A NOS1	1.10e-05	195	172	7	19853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SHROOM3 PPFIA4 PRKAG3 MMP25 TLR4 SCN10A NOS1	1.10e-05	195	172	7	d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCell	LV-09._Endothelium_I\|World / Chamber and Cluster_Paper	FLT1 RUNDC3B MGAT4A FRYL MCTP1 CLEC14A MCF2L	1.10e-05	195	172	7	19e0a6c3eae1615aaa39767300acd937dfcb2a7f
ToppCell	Neuronal-Excitatory-eC(RORB)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HTR1F SPOCK1 GRB7 PTCHD4 PTGFRN KCNH1 KCNH5	1.30e-05	200	172	7	8c803a0ce25e140b46036f6aabefc5502601f408
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK-ILC\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SELL GINS3 TCF7 MYO7A ABT1 ADAM28 CYP4F22	1.30e-05	200	172	7	49ad6e2337886367fbfa2a7c7366687b701ddf39
ToppCell	metastatic_Brain-T/NK_cells-CD8_low_T\|T/NK_cells / Location, Cell class and cell subclass	CREBRF ABCA6 TLR4 CFAP74 SLC14A2 UNC79	1.62e-05	138	172	6	b2ab273f3e62f169b3b9cb82342e6617af99f582
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SELL CDR1 NTSR1 CCDC141 KLLN FOXP3	2.80e-05	152	172	6	6d02b50e9e9ecf820f84a79e46d153a4840a1cfe
ToppCell	facs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 SPOCK1 SLC2A4 VSTM4 ERMAP TRPV4	3.73e-05	160	172	6	56e6f4b82b5dc41c45f9d253c2db314a6f702b84
ToppCell	facs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 SPOCK1 SLC2A4 VSTM4 ERMAP TRPV4	3.73e-05	160	172	6	bb1b966fb9e801db15e67d03e49db4609d6f935a
ToppCell	facs-Marrow-Granulocytes-18m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 SPOCK1 SLC2A4 VSTM4 ERMAP TRPV4	3.86e-05	161	172	6	60f433eab9d5531bdf6aa86b0265f20b866b904c
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CDR1 NTSR1 OBSCN GRB7 TIAM2 ST6GALNAC5	4.13e-05	163	172	6	218b9ba099cb27aa91c6b73bf89b44895f5dddc3
ToppCell	droplet-Skin-nan-18m-Epithelial-stem_cell_of_epidermis\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP49 GINS3 KIF23 AKAP5 PRKAG3 TIGD3	4.43e-05	165	172	6	96f0d8bc9b13e23f757e6bb98cd7dc061a8a9564
ToppCell	343B-Myeloid-Macrophage-FABP4+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	RTEL1 PAPOLG GTF3C2 ERCC6L2 ROS1 SENP7	4.58e-05	166	172	6	f62db9d9b6c9dd8f2afcaea0fc5f8c69f50205b2
ToppCell	facs-Lung-EPCAM-24m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELL NTSR1 SCN10A GSDMA CACNA1I UNC79	4.73e-05	167	172	6	691f3589de0f8c13f9137812cfa9040c07d237b4
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-5_RORB_CMAHP\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HTR1F COL22A1 PTCHD4 PTGFRN SCN3A KCNH5	4.89e-05	168	172	6	1d58731a481ecac84c15affa84f8041dd67d944c
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SHROOM3 HTR1F COL22A1 PTGFRN ROS1 KCNH5	5.23e-05	170	172	6	3174ea9cf93892a8b41de10fd4ff6f06bb41502d
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	HTR1F TMC4 PTH1R SLC2A4 NOTUM C11orf96	5.40e-05	171	172	6	a4a2c5dc995589fbe3d4ca6ee1df888807e4ae34
ToppCell	5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT1 DGKE TMEM255B MCTP1 CLEC14A MCF2L	5.40e-05	171	172	6	b3e6e31dfe3623b960ccf692fdbd236fa4039923
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-5_RORB_CMAHP\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HTR1F COL22A1 PTCHD4 PTGFRN SCN3A KCNH5	5.40e-05	171	172	6	9d5cabd71a901a00eb16c4d151189296f1b3bf6f
ToppCell	Control-Endothelial_cells-Systemic_venous_endothelial_cells\|Control / group, cell type (main and fine annotations)	FLT1 RUNDC3B TMEM255B MCTP1 CLEC14A MCF2L	5.58e-05	172	172	6	c55dce1ed3ed7312394b4e050e1de852a994e130
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_SEMA6D\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HTR1F GRB7 PTGFRN KCNH1 ROS1 KCNH5	5.76e-05	173	172	6	9a2d42f8d9cb834856522661d524abb91c4637c5
ToppCell	AT1_cells-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	BDNF CNTN6 ST6GALNAC5 PAM IRX2 VCL	5.76e-05	173	172	6	3afca2a429c634af0220c1aa19ce4cf4ee3e8b3e
ToppCell	Control-Myeloid-MoAM2,_CCL18\|Control / Condition, Lineage and Cell class	MYO7A TLR6 VSTM4 FAM20C ABCA6 GSDMA	5.95e-05	174	172	6	4c64ff5666812fb4efa440ba4faeca51d916d68e
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	OBSCN ADAM28 PXDN ABCA6 KCNH1 GREB1	5.95e-05	174	172	6	f90ca117b729436cf452e2ddcec26ba525c5c13b
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-SMG_basal_2\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	COL22A1 STOX1 NOXO1 TRPV4 UNC79 DNAH11	6.14e-05	175	172	6	4462000b22af227555413ba202a872868eecde6c
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-late_pro_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GINS3 MYO7A GLA TIGD3 DNAH11 C4orf46	6.33e-05	176	172	6	aa1bada2175d8370fc71939a607407155259d195
ToppCell	droplet-Bladder-nan-24m-Hematologic-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELL RUNDC3B GCG MMP25 RASAL3 FOXP3	6.33e-05	176	172	6	0089b50d607f4d2f18639fab0f3fc779227baa7a
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GINS3 MYO7A GLA TIGD3 DNAH11 C4orf46	6.33e-05	176	172	6	3766e0533b103ec92ac75eba3df02e287efc53fa
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_LINC01474\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HTR1F GRB7 PTCHD4 PTGFRN KCNH1 KCNH5	6.33e-05	176	172	6	cd4b9211652596c42e7af318bcd464681daebb10
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 DGKE COLGALT2 ZNF284 MCTP1 CLEC14A	6.33e-05	176	172	6	1df7b6ce2519ad99bacbbaf1a8d5929e11513faa
ToppCell	Control-Myeloid-MoAM2,_CCL18\|Myeloid / Condition, Lineage and Cell class	MYO7A TLR6 VSTM4 FAM20C ABCA6 GSDMA	6.54e-05	177	172	6	470f54fe2b21c7350ea471e02039461a3808f700
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	REC114 GCG SCN3A PAM IRX2 DNAH11	6.54e-05	177	172	6	426a9845df7fd13b02e744532c336c60bc4d4a22
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	REC114 GCG SCN3A PAM IRX2 DNAH11	6.54e-05	177	172	6	1dc69c661e70e7e22bd9d7cf953eb638da9fd43c
ToppCell	droplet-Limb_Muscle-nan-21m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP5 PTH1R NOTUM ERMAP GTF2IRD2 IRX2	6.54e-05	177	172	6	291231b1520c135e92739e201495fe1935efa927
ToppCell	Control-Epithelial_alveolar-AT_1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM3 CNTN6 MYO3B ST6GALNAC5 IRX2 SLC22A31	6.74e-05	178	172	6	aa7d43c655df493f1330a5001efaa484e4a19f69
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HTR1F COL22A1 PTCHD4 BDNF KCNH1 KCNH5	6.74e-05	178	172	6	731e1e8eff2c4018c75dfc66632a316010a09a9a
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 SETD1A TLR6 VSTM4 C11orf96 UNC79	6.95e-05	179	172	6	b44e2d53b82c3c141bfc6539054b19708200a0d9
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SHROOM3 GRB7 BDNF ST6GALNAC5 OSGIN2 IRX2	6.95e-05	179	172	6	d5e3e7f1cd8f683f39a7416f12af7e766dcbead8
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma-10\|TCGA-Colorectal / Sample_Type by Project: Shred V9	COL22A1 TLR6 PXDN ST6GALNAC5 TLR1 MYO1F	6.95e-05	179	172	6	cc079ba015326dccde955c5eafa3e4a2e40de192
ToppCell	droplet-Heart-nan-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC2A4 VSTM4 PIANP KCNH1 C11orf96 VCL	7.17e-05	180	172	6	78fdcfb3fdbf36469cae78407cda5bd0996930d8
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	WSCD1 FLT1 DGKE TMEM255B FZD6 CLEC14A	7.39e-05	181	172	6	9bfd93cf053beaee806cacdffd7abef02f94aec6
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c02-AQP3\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	SELL TRADD TCF7 DEAF1 OGDH NSD3	7.86e-05	183	172	6	317b756378a9efd8ecb754acf7273f83f996e106
ToppCell	E18.5-samps-Mesenchymal-Myofibroblast\|E18.5-samps / Age Group, Lineage, Cell class and subclass	TCF7 COL22A1 PTH1R PXDN C11orf96 GREB1	7.86e-05	183	172	6	de08f9ea02b7244d5a8788064631d10f06565337
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ACSS1 MYO3B ADAMTS17 LRBA IRX2 NOS1	7.86e-05	183	172	6	31ab55d5f3639f5964541d5eae23044dbda3356e
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FLT1 DGKE PTCHD4 MCTP1 CLEC14A MCF2L	7.86e-05	183	172	6	c1297d8eddfc7132e84ceef14f01b6281f9d0f6a
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 OBSCN COL22A1 ROS1 UNC79 DNAH11	8.10e-05	184	172	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SHROOM3 BDNF CNTN6 FZD6 ST6GALNAC5 IRX2	8.10e-05	184	172	6	29c95b814a0b1ad8734ed68b77df29c08594e5ec
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PTH1R MYO3B ST6GALNAC5 ADAMTS17 LRBA NOS1	8.10e-05	184	172	6	e8238fe58f94b4f5700ab7f343fb06ea61e899a9
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 OBSCN COL22A1 ROS1 UNC79 DNAH11	8.10e-05	184	172	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	367C-Epithelial_cells-Epithelial-A_(AT2)\|367C / Donor, Lineage, Cell class and subclass (all cells)	SHROOM3 GRB7 CCDC141 ROS1 IRX2 SLC22A31	8.10e-05	184	172	6	0ba243cbf69b4fe6ae100a7f0314317bec38026c
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 OBSCN COL22A1 ROS1 UNC79 DNAH11	8.10e-05	184	172	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	Mesenchymal_cells-Smooth_muscle\|Mesenchymal_cells / Lineage and Cell class	INPP5A ACSS1 TMEM255B BDNF SLC2A4 C11orf96	8.10e-05	184	172	6	83987abaedc26e6da477bc70d65e10b1ab1aea60
ToppCell	367C-Epithelial_cells-Epithelial-A_(AT2)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	SHROOM3 GRB7 CCDC141 ROS1 IRX2 SLC22A31	8.10e-05	184	172	6	2a8338e94937686a148b5433515700ca0f674058
ToppCell	Control-Epithelial_alveolar-AT_2-Differentiating_AT2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM3 ST6GALNAC5 ADAMTS17 LRBA IRX2 SLC22A31	8.34e-05	185	172	6	0d2add28ac1f4fa6de7699be009bf8391badaf4c
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 GCG SCN3A PAM IRX2 DNAH11	8.34e-05	185	172	6	4e40d3103ebf4a7066b7ce300b6ef700ba0e2863
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM3 GRB7 PTH1R CNTN6 IRX2 SLC22A31	8.34e-05	185	172	6	c82eab551f65ecebe6db908eda9f9eb3414693c7
ToppCell	Control-Epithelial-ATI\|World / Disease state, Lineage and Cell class	SHROOM3 BDNF CNTN6 RPL39P5 ST6GALNAC5 IRX2	8.34e-05	185	172	6	0563d5042bb96ecce8446fbf26d05ef7a45e23c5
ToppCell	droplet-Lung-LUNG-30m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 FZD6 KCNH1 CLEC14A C11orf96 TRPV4	8.59e-05	186	172	6	41f1674afc17661eccaa779cdeb663db5e45685d
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 GCG SCN3A PAM IRX2 DNAH11	8.59e-05	186	172	6	16092819e9148dfe64f07c737652b6e533e699f7
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GCG ST6GALNAC5 SCN3A PAM IRX2 DNAH11	8.59e-05	186	172	6	4bb54043f944a979db91bde9a86dd66f498c7658
ToppCell	droplet-Lung-LUNG-30m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 FZD6 KCNH1 CLEC14A C11orf96 TRPV4	8.59e-05	186	172	6	aa006650cf21a2c51dfe1091681f67fdad939107
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ONECUT2 COL22A1 ADAM28 SCN3A MCF2L UNC79	8.59e-05	186	172	6	b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCell	Epithelial-alveolar_epithelial_cell_type_1\|World / Lineage, Cell type, age group and donor	SHROOM3 BDNF CNTN6 FZD6 ST6GALNAC5 IRX2	8.59e-05	186	172	6	09d95daa3387a4814cffaa4b798cc2810c3759d0
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ACSS1 MYO3B ADAMTS17 LRBA IRX2 NOS1	8.85e-05	187	172	6	b93cf4dfe8ffb89348ee7bccc9f284189f7240a2
ToppCell	COVID-19-Endothelial_cells-Pulmonary_venous_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	FLT1 RUNDC3B TMEM255B MCTP1 MCF2L NOS1	8.85e-05	187	172	6	2d20193a6cacdfa4877457c97b0077408942186c
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM3 GRB7 TMC4 PTH1R CNTN6 SLC22A31	8.85e-05	187	172	6	58d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SHROOM3 BDNF CNTN6 FZD6 ST6GALNAC5 VCL	8.85e-05	187	172	6	d4b0afd9b92c47c8aa348bbd1af7eb54c3d478f2
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	WSCD1 FLT1 MGAT4A MCTP1 CLEC14A MCF2L	8.85e-05	187	172	6	dffa8447c2f3fdacf39a7258c6b4e81a25245041
ToppCell	Mesenchymal_cells-Ng2+_MSCs\|Mesenchymal_cells / Lineage and Cell class	SPOCK1 COL22A1 PTH1R FAM20C SLC25A13 CDH15	8.85e-05	187	172	6	e899b906409f3fad69cb3d3c6432c3fd862ae3c1
ToppCell	Children_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FLT1 RUNDC3B DGKE FRYL CLEC14A MCF2L	9.11e-05	188	172	6	117dc80fa940e6aa1b0187a43fdde33f3fcb578f
Computational	Genes in the cancer module 135.	CYP2C19 CYP2C8 CYP2C18 NOS1	5.54e-05	25	92	4	MODULE_135
Computational	Cytochrome P450.	CYP2C19 CYP2C8 CYP2C18	2.06e-04	14	92	3	MODULE_106
Drug	5-MeO-DIPT	CYP2C19 CYP2C8 OXCT2 DMTN	2.77e-06	14	169	4	CID000151182
Drug	phenytoin	CYP2C19 CYP2C8 CYP2C18 SCN3A PKD1 SCN10A ORAI3 CACNA1I NOS1 DMTN	5.83e-06	219	169	10	CID000001775
Drug	4',5-dihydroxydiclofenac	CYP2C19 CYP2C8 CYP2C18	7.90e-06	6	169	3	CID003052567
Drug	3'-hydroxydiclofenac	CYP2C19 CYP2C8 CYP2C18	7.90e-06	6	169	3	CID000112230
Drug	risperidone	CYP2C19 CYP2C8 HTR1F GCG NT5C1B BDNF KCNH1 KCNH5	8.20e-06	136	169	8	CID000005073
Drug	6-Fluoro-6-desoxyoxymorphone	CYP2C19 CYP2C8 OXCT2	1.38e-05	7	169	3	CID005486899
Drug	S-(+)-ibuprofen [51146-56-6]; Down 200; 19.4uM; MCF7; HT_HG-U133A	RTEL1 KDM5A GRB7 RGS12 NSD3 YLPM1 MYO1F CWF19L1 DMTN	1.65e-05	196	169	9	6471_DN
Disease	X-14473 measurement	CYP2C19 CYP2C18	3.03e-05	2	163	2	EFO_0021370
Disease	cyclo(leu-pro) measurement	CYP2C19 CYP2C18	9.07e-05	3	163	2	EFO_0800676
Disease	vulva squamous cell carcinoma (is_marker_for)	CDC25A CDC25B	9.07e-05	3	163	2	DOID:2101 (is_marker_for)
Disease	X-21258 measurement	CYP2C19 CYP2C18	9.07e-05	3	163	2	EFO_0800802
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TLR6 TLR1 TLR4	1.06e-04	17	163	3	DOID:8677 (biomarker_via_orthology)
Disease	Dyschondroplasias	FLT1 PTH1R TRPV4	1.50e-04	19	163	3	C0013366
Disease	migraine disorder	WSCD1 ONECUT2 CYP2C19 INPP5A RNF213 ADAM28 VSTM4 MYO3B SCN10A	1.75e-04	357	163	9	MONDO_0005277
Disease	Urination Disorders	TRPV4 NOS1	1.81e-04	4	163	2	C0042035
Disease	invasive aspergillosis (is_implicated_in)	CYP2C19 TLR4	1.81e-04	4	163	2	DOID:0050073 (is_implicated_in)
Disease	sciatic neuropathy (implicated_via_orthology)	BDNF TLR4 SCN10A	2.70e-04	23	163	3	DOID:11446 (implicated_via_orthology)
Disease	epilepsy (implicated_via_orthology)	KCNH1 SCN3A SCN10A NOS1 DYNC1H1 KCNH5	3.01e-04	163	163	6	DOID:1826 (implicated_via_orthology)
Disease	Malignant neoplasm of breast	FLT1 CATSPERE RPS9 OBSCN GRB7 DGKE COLGALT2 CNTN6 CUL5 FCRL3 KCNH1 CHD5 LRBA ZBTB3 NIPBL FOXP3	3.16e-04	1074	163	16	C0006142
Disease	Epilepsy	SETD1A ILK BDNF KCNH1 KCNH5	3.56e-04	109	163	5	C0014544
Disease	necrotizing enterocolitis	ADAM28 TIAM2 MCTP1	4.39e-04	27	163	3	EFO_0003928
Disease	leukocyte immunoglobulin-like receptor subfamily B member 3 measurement	RPS9 TMC4	4.48e-04	6	163	2	EFO_0802705
Disease	tuberculosis (is_implicated_in)	CYP2C19 TLR6 TLR1	4.90e-04	28	163	3	DOID:399 (is_implicated_in)
Disease	matrix metalloproteinase 7 measurement	RPS9 MMP25	8.31e-04	8	163	2	EFO_0010591
Disease	aspergillosis (is_implicated_in)	TLR6 TLR1	8.31e-04	8	163	2	DOID:13564 (is_implicated_in)
Disease	helix rolling	ONECUT2 LRBA	8.31e-04	8	163	2	EFO_0007670
Disease	sick sinus syndrome	CCDC141 SCN10A	8.31e-04	8	163	2	MONDO_0001823
Disease	familial sick sinus syndrome	CCDC141 SCN10A	8.31e-04	8	163	2	MONDO_0012061
Disease	Attached earlobe	GCG MYO3B	8.31e-04	8	163	2	HP_0009907
Disease	Alzheimer's disease (is_implicated_in)	GCG NCSTN BDNF TLR4 NOS1	8.51e-04	132	163	5	DOID:10652 (is_implicated_in)
Disease	serine measurement	OGDH SCN3A DYNC1H1	9.51e-04	35	163	3	EFO_0009774
Disease	plasma clozapine-to-N-desmethylclozapine ratio measurement	CYP2C19 CYP2C18	1.06e-03	9	163	2	EFO_0600040
Disease	Profound Mental Retardation	RALGDS DEAF1 KDM5A BDNF DYNC1H1	1.07e-03	139	163	5	C0020796
Disease	Mental Retardation, Psychosocial	RALGDS DEAF1 KDM5A BDNF DYNC1H1	1.07e-03	139	163	5	C0025363
Disease	Mental deficiency	RALGDS DEAF1 KDM5A BDNF DYNC1H1	1.07e-03	139	163	5	C0917816
Disease	cutaneous leishmaniasis (is_marker_for)	TLR4 FOXP3	1.33e-03	10	163	2	DOID:9111 (is_marker_for)
Disease	age at menarche, spine bone mineral density	RUNDC3B KCNH1	1.33e-03	10	163	2	EFO_0004703, EFO_0007701
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN3A SCN10A	1.33e-03	10	163	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN3A SCN10A	1.33e-03	10	163	2	DOID:0080422 (implicated_via_orthology)
Disease	prostate adenocarcinoma (is_marker_for)	ILK PAM	1.33e-03	10	163	2	DOID:2526 (is_marker_for)
Disease	pleural tuberculosis (is_marker_for)	TLR4 FOXP3	1.33e-03	10	163	2	DOID:106 (is_marker_for)
Disease	Ischemic stroke, coronary artery disease	RNF213 NT5C1B RASAL3 SLC14A2	1.72e-03	92	163	4	EFO_0001645, HP_0002140
Disease	multiple sclerosis	SETD1A TCF7 GRB7 FAM47B GCG PTGFRN SLC2A4 FCRL3 MCTP1 CDH15	1.79e-03	594	163	10	MONDO_0005301
Disease	asthma (is_implicated_in)	TLR6 BDNF TLR1 TLR4 NOS1	1.84e-03	157	163	5	DOID:2841 (is_implicated_in)
Disease	left ventricular systolic function measurement	OBSCN CCDC141 PXDN	1.86e-03	44	163	3	EFO_0008206
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN3A SCN10A	1.93e-03	12	163	2	DOID:0060170 (implicated_via_orthology)
Disease	retinopathy of prematurity (biomarker_via_orthology)	FLT1 NOS1	1.93e-03	12	163	2	DOID:13025 (biomarker_via_orthology)
Disease	outer ear morphology trait	MYO3B LRBA	1.93e-03	12	163	2	EFO_0007664
Disease	intracranial aneurysm (is_implicated_in)	COL22A1 PKD1	1.93e-03	12	163	2	DOID:10941 (is_implicated_in)
Disease	Neurobehavioral Manifestations	UBE4B NOS1	1.93e-03	12	163	2	C0525041
Disease	S-warfarin to R-warfarin ratio measurement	CYP2C19 CYP2C8 CYP2C18 ADAMTS17	1.93e-03	95	163	4	EFO_0803331
Disease	diabetic retinopathy (biomarker_via_orthology)	FLT1 BDNF NOS1	1.98e-03	45	163	3	DOID:8947 (biomarker_via_orthology)
Disease	sciatic neuropathy (biomarker_via_orthology)	CERS2 BDNF TLR4 CACNA1I	2.25e-03	99	163	4	DOID:11446 (biomarker_via_orthology)
Disease	serum IgG glycosylation measurement	REC114 TOPAZ1 TMEM255B MCTP1 PXDN TLR4 ERCC6L2 ADAMTS17 CACNA1I	2.60e-03	523	163	9	EFO_0005193
Disease	Kawasaki disease (is_marker_for)	FLT1 TLR4	2.64e-03	14	163	2	DOID:13378 (is_marker_for)
Disease	triacylglycerol 46:2 measurement	GTF3C2 MYO3B	2.64e-03	14	163	2	EFO_0010402
Disease	vascular dementia (biomarker_via_orthology)	FLT1 BDNF	2.64e-03	14	163	2	DOID:8725 (biomarker_via_orthology)
Disease	diabetic neuropathy (implicated_via_orthology)	BDNF TLR4	2.64e-03	14	163	2	DOID:9743 (implicated_via_orthology)
Disease	diabetic retinopathy (is_implicated_in)	FLT1 MYSM1 TLR4	2.68e-03	50	163	3	DOID:8947 (is_implicated_in)
Disease	Seizures, Focal	BDNF PAM NOS1 DYNC1H1	2.69e-03	104	163	4	C0751495
Disease	Alzheimer's disease (is_marker_for)	SELL AKAP5 STOX1 BDNF NOS1 DYNC1H1	3.14e-03	257	163	6	DOID:10652 (is_marker_for)
Disease	nervous system disorder	CYP2C8 BDNF NOS1	3.17e-03	53	163	3	C0027765
Disease	decreased susceptibility to hepatitis C infection	COL22A1 PTGFRN	3.46e-03	16	163	2	EFO_0010101
Disease	Spondyloepiphyseal Dysplasia	FLT1 TRPV4	3.46e-03	16	163	2	C0038015
Disease	Spondyloepiphyseal Dysplasia Tarda, X-Linked	FLT1 TRPV4	3.46e-03	16	163	2	C3541456
Disease	cerebellum white matter volume change measurement	ONECUT2 SPOCK1	3.46e-03	16	163	2	EFO_0021498
Disease	Schwartz-Jampel Syndrome, Type 1	FLT1 TRPV4	3.46e-03	16	163	2	C4551479
Disease	Pre-Eclampsia	FLT1 STOX1	3.46e-03	16	163	2	C0032914
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	PKD1 CDC25A	3.46e-03	16	163	2	DOID:0110861 (implicated_via_orthology)
Disease	Schwartz-Jampel Syndrome	FLT1 TRPV4	3.46e-03	16	163	2	C0036391
Disease	Melnick-Needles Syndrome	FLT1 TRPV4	3.46e-03	16	163	2	C0025237
Disease	Intellectual Disability	SETD1A RALGDS ZMYND11 DEAF1 KDM5A BDNF SCN3A DYNC1H1	3.52e-03	447	163	8	C3714756
Disease	Renal Insufficiency	GLA TLR4	3.91e-03	17	163	2	C1565489
Disease	Moyamoya Disease	RNF213 GLA	3.91e-03	17	163	2	C0026654
Disease	Van Buchem disease	FLT1 TRPV4	3.91e-03	17	163	2	C0432272
Disease	Charcot-Marie-Tooth disease type 2	TRPV4 DYNC1H1	3.91e-03	17	163	2	cv:C0270914
Disease	Tourette syndrome, schizophrenia	NSD3 CACNA1I	4.38e-03	18	163	2	EFO_0004895, MONDO_0005090
Disease	omega-6 polyunsaturated fatty acid measurement	PTCHD4 PRKAG3 ABCA6 TLR4 DNAH11	4.86e-03	197	163	5	EFO_0005680
Disease	Osteochondrodysplasias	FLT1 TRPV4	4.88e-03	19	163	2	C0029422
Disease	limited scleroderma	TLR1 GSDMA	4.88e-03	19	163	2	EFO_1001017
Disease	cholesterol to total lipids in medium VLDL percentage	RGS12 PRKAG3 ABCA6	5.16e-03	63	163	3	EFO_0022239
Disease	cholesteryl esters to total lipids in medium VLDL percentage	RGS12 PRKAG3 ABCA6	5.39e-03	64	163	3	EFO_0022253
Disease	sucrose liking measurement	WSCD1 ORC5	5.40e-03	20	163	2	EFO_0010157
Disease	Multiple Epiphyseal Dysplasia	FLT1 TRPV4	5.40e-03	20	163	2	C0026760

Protein segments in the cluster

Peptide	Gene	Start	Entry
SWRSKTLKDCRIFLR	nan	416	A8MVM7
AASSGARVLKTLRRW	NT5C1B	541	Q96P26
WVKKYDRSSLRTLGS	ACSS1	401	Q9NUB1
HSSWKRKSSRRIDRF	ARHGEF10L	106	Q9HCE6
KRITGRKRLSKGFWS	C8orf44	136	Q96CB5
DSKKRIGWRFIRIDT	BDNF	221	P23560
RRTLWSLVAFPKLKR	CUL5	631	Q93034
LLKAKGRRSTFAVWT	CATSPERE	341	Q5SY80
WLVRDLRGKSEKEFR	CHD5	1451	Q8TDI0
GKRRAKALRWTRQKS	PRKAG3	51	Q9UGI9
RSLRSEFKHEKSWRR	HTR1F	266	P30939
FSKWRGSVLSRRKRH	ADAM28	276	Q9UKQ2
LLLKRSGREITWKDF	AFG3L2	161	Q9Y4W6
TSISSRKRGKRRYFW	CREBRF	421	Q8IUR6
NARFLKTWRDLLKEG	C4orf46	91	Q504U0
RKRKSTLFWGARYVR	GSDMA	41	Q96QA5
ISFIFRKRRKNSGLW	ABCA6	1116	Q8N139
GELDVKRAFAKWRRN	AKTIP	156	Q9H8T0
NGKRWKEIRRFSLTT	CYP2C8	116	P10632
RRFAKEIWSLNKEVR	DNAH11	1361	Q96DT5
WKNKERILIFSSRGI	BRIX1	56	Q8TDN6
LAIAIFIRWKKSRAF	PAM	881	P19021
KRKLGFYEWTSRLRS	GLA	391	P06280
GGRRRFFWKTLTDWK	CDR1	221	P51861
RPSLLKKFREASWRF	CERS2	126	Q96G23
VRYVRRGLWEKISAK	ADAMTS17	741	Q8TE56
QRELRRFSRKEKGLW	POLM	441	Q9NP87
EKLREGRDASRWLNK	NBPF4	111	Q96M43
RYNSKRRHWKRTKLG	RPL39P5	36	Q59GN2
KESRTSRLRLSKALW	RASAL3	76	Q86YV0
FSLIGSKDWLKIVRR	REC114	86	Q7Z4M0
ERFSSRSKARTEWKL	GOLGA8S	196	H3BPF8
SRWKDIRARIFLIAS	NCSTN	651	Q92542
WRRLYLSRAKLKASS	ORAI3	51	Q9BRQ5
RHTSRKLRDFKWAGD	FAM47C	846	Q5HY64
LKETFGDSKERVRWR	MGAT4A	221	Q9UM21
RRYALSGSVWKKRTL	MMP25	106	Q9NPA2
SRWSGFKKRKQVLDR	MCTP1	76	Q6DN14
WTVDELEFRKKRSQR	FOXP3	406	Q9BZS1
YALLGLRKWSSKTRA	GREB1	1691	Q4ZG55
SRSRTKKFISAIWLA	NTSR1	181	P30989
LLKVAWKRRLIFTVG	DTX2	551	Q86UW9
RKSLKRLTGWADVSG	SLC2A4	241	P14672
VEKWKAEREARLARG	ISY1	186	Q9ULR0
DDKVFRRAPSWRKRF	PPFIA4	1111	O75335
DSTKGWTKFARLTRA	KCNH5	141	Q8NCM2
TLRRFFKSRGKWCVV	CWF19L1	391	Q69YN2
FPECKWSRKGFIRTR	INPP5A	156	Q14642
LDKWGAFRARLFRES	CTDSP1	166	Q9GZU7
FRKFKSIKARDVGWS	DCAF11	206	Q8TEB1
FNWGVRRRSLDSIDK	FRYL	2446	O94915
RRHTSRKLRDFKWAG	FAM47B	456	Q8NA70
GSWTEAKRRDGRKLV	NIPBL	2746	Q6KC79
KPWSKLKSGRETFRR	ONECUT2	376	O95948
RKIFLLVQSRKWRDG	KCT2	221	Q8NC54
KGWGKFARLTRALTS	KCNH1	146	O95259
GKWLFTEIRSIFSRR	LRBA	2131	P50851
SGLAFIIWLARRLKK	SELL	346	P14151
TFRLKTRSWAGERSR	CDC25B	556	P30305
LWTFLLQRRFVKKRG	GDPD2	506	Q9HCC8
AKEFIAWLVKGRGRR	GCG	116	P01275
FKRRWKDTRATVGTT	KLLN	46	B2CW77
EVKEAARKVWGRSRA	OR13J1	296	Q8NGT2
RAWRERTGRTFLKKN	KDM5A	1051	P29375
LQLRGSGRKLWKRFF	GRB7	236	Q14451
VSTWFANARRRLKKE	IRX2	161	Q9BZI1
DRSWKRNKFRLTFVA	NOS1	966	P29475
ALLAEAAVGRKRKWS	OBSCN	7376	Q5VST9
LKESRGSRRWLLFLE	NOTUM	111	Q6P988
EFLQRKWSSEKRFGL	OGDH	266	Q02218
KETFRLTLRAVKLWA	PAPOLG	216	Q9BWT3
DWVSSKRRSLKGDRV	OSGIN2	156	Q9Y236
KGTEGRERAFKQWLR	CCDC181	446	Q5TID7
TEWAGFFKRNRKRDP	FZD6	501	O60353
TEGWVEFRDKRIAKR	ABT1	106	Q9ULW3
KWRAKAEEYGRTLSR	CCDC141	881	Q6ZP82
GIVFSNGKRWKEIRR	CYP2C19	111	P33261
RASSKDWKRSIRYAG	DEAF1	246	O75398
WLRRGKTLKLIFSLR	EPM2AIP1	341	Q7L775
RDVTRDKKLWRTFFI	FAM20C	341	Q8IXL6
WRETRAKLRGIVDSK	CACNA1I	626	Q9P0X4
VLKVRDWSTRKSRDF	ILK	221	Q13418
LRWYRDRKELKGVSS	CADM4	156	Q8NFZ8
KEFRKTWGFRRTTIA	DIDO1	21	Q9BTC0
TWGFRRTTIAKREGA	DIDO1	26	Q9BTC0
RGAWASLKRLVTRRK	AKAP5	76	P24588
ISWKRGTETLRQSKR	CNTN6	441	Q9UQ52
VTTFRFRKTSRKEDW	COL22A1	296	Q8NFW1
SWHKEGRVRSLGRKT	FCRL3	321	Q96P31
RLKKTWEDVSRDSFR	RALGDS	496	Q12967
DRRRDKWTSVKASVL	MCF2L	136	O15068
LSKEVRNLKWLGFRV	DYNC1H1	746	Q14204
GILFSNGKRWKEIRR	CYP2C18	111	P33260
RRDIFRKSKHGWRDT	DGKE	51	P52429
SGWFLRRTKTLIKDQ	ERCC6L2	376	Q5T890
FDKWTDSQRRRILTG	FBXO16	46	Q8IX29
KLRQAALRTAREKWS	COLGALT2	146	Q8IYK4
IKWLSRGLVLKRFFE	GTF2IRD2	711	Q86UP8
IKWLSRGLVLKRFFE	GTF2IRD2B	711	Q6EKJ0
VETEWRKRKASRRGA	DMTN	201	Q08495
RARKILWRFAEASGV	SLC22A31	281	A6NKX4
RRRGAAKWAAVRAKA	UTP3	6	Q9NQZ2
LRSKKAVDWRLFRNI	SLC20A1	636	Q8WUM9
LRARFWKQSRGKGLL	CDH15	626	P55291
RDTLRKFQAWDRAKA	CFAP74	296	Q9C0B2
LSKGDKWSRHRRLLT	CYP4F22	146	Q6NT55
FRTKSRTWAGEKSKR	CDC25A	501	P30304
KRGRWAARTFSNKTL	PKD1	2401	P98161
AFEVFWRGQKKRRIA	KIF23	276	Q02241
RSELKLKRAAANSGW	ERMAP	216	Q96PL5
RKGIVTTSRRDWKSD	PTGFRN	751	Q9P2B2
SSSRAKGRAWIRVAL	RUNDC3B	136	Q96NL0
WSTTAARKRGKVLSY	RTEL1	441	Q9NZ71
GLRNKREVWRVKFTL	RPS9	36	P46781
LTNVLWTDLGRKFRK	SENP7	101	Q9BQF6
WERLSSTKRAVKAAL	CARS2	396	Q9HA77
WLAKGLFDNKRRILS	GINS3	71	Q9BRX5
TFARSVGLKWRKVGR	TRADD	221	Q15628
EGLSRRKKTSLWFVG	TMEM255B	16	Q8WV15
EKLREGRDASRWLNK	NBPF5P	111	Q86XG9
EKLREGRDASRWLNK	NBPF6	111	Q5VWK0
VKGEASERDTRKLWR	ORC5	241	O43913
GIIFKFCWDRSQKRR	PIANP	196	Q8IYJ0
TKGVFELLSGWRRTK	PTCHD4	306	Q6ZW05
WSGGVKLRLKHRRSE	SHROOM3	141	Q8TF72
RFITEKRVFKNWART	ST6GALNAC5	296	Q9BVH7
RSFRLLRVFKLAKSW	SCN3A	851	Q9NY46
TFVRRSWDEFRQLKK	NOXO1	36	Q8NFA2
RKKKLRFGRSRIHEW	SETD1A	1566	O15047
RAIRADFALVKGWKA	OXCT2	201	Q9BYC2
EKSKRGLFWANLRAA	TLR1	761	Q15399
FKIKDGSFITLRSRW	ARNTL	406	O00327
KALWKGAGARVFRSS	SLC25A13	576	Q9UJS0
GSKDLLFWVALERRR	CLEC14A	86	Q86T13
VRRKGAGRARFKWHS	C11orf96	186	Q7Z7L8
TLAATKRWLREVFTK	RNF213	906	Q63HN8
KADALRALGTLRRWF	TIGD3	431	Q6B0B8
KKRKGAFFSWSRTRS	RGS12	891	O14924
RRISDWTGSLSRKKR	TIAM2	381	Q8IVF5
RWTLALDFKRKARSG	PTH1R	476	Q03431
RSFRLLRVFKLAKSW	SCN10A	756	Q9Y5Y9
RLLDKESSKWRLRGQ	RNF123	296	Q5XPI4
FGFSLLWRSLSRKEK	STOX1	311	Q6ZVD7
TDRWARLLRRSKEKT	TMC4	121	Q7Z404
LVCKIFRVSWKDRDR	UBE4B	161	O95155
LSTQFKRLRDGDRLW	PXDN	1236	Q92626
IRTDAGFTLRWVRKT	VCL	1116	P18206
LARTLRLWFEKSSRG	USP49	151	Q70CQ1
RLWFEKSSRGQAKLE	USP49	156	Q70CQ1
KELRNLASRLKDWFG	SPOCK1	201	Q08629
QWLFLSRKTSLRKRS	ROS1	291	P08922
WSARDNYGKKKRRSR	TCF7	336	P36402
KTERRGWGLRTKRSI	NSD3	1151	Q9BZ95
EKSKRGLFWANIRAA	TLR6	766	Q9Y2C9
RTGTKRKRDWEAIAS	YLPM1	2061	P49750
KSFSWRADLLKHRRL	ZNF697	296	Q5TEC3
ITSLGRSRLWLKARA	TOPAZ1	1541	Q8N9V7
AKENGWRARSAFKLL	FTSJ1	16	Q9UET6
KDRTRRAWEKFNKRA	ZNF786	211	Q8N393
FLREGRFWKSKNEDR	ZMYND11	356	Q15326
SAGSDRKIKFWDLRR	GTF3C2	631	Q8WUA4
KRRKDSLLAVRWFFA	VSTM4	51	Q8IW00
KGFKGEKDHWRSRRT	WSCD1	391	Q658N2
SRDTWLKKARVVRLG	XPC	686	Q01831
GKRIIWDSRKGFIIS	FLT1	181	P17948
IFWRRLRKALLDGKS	TLR4	806	O00206
IEWSSIRRRSKVFGK	SLC14A2	481	Q15849
NELLRDKWRKFGAVS	TRPV4	456	Q9HBA0
KRYWLLKAQSRTGRF	USP32	201	Q8NFA0
GKSFRWASGILRHKR	ZNF284	461	Q2VY69
ITKTALDFWRAGRKR	TOR1B	221	O14657
AALWKIKRARFARNR	UNC79	1206	Q9P2D8
KAWERKRSLLRGAVG	ZBTB3	16	Q9H5J0
RKFDGFARTIQKAWR	MYO1F	691	O00160
TKGWLGARRYKRVRE	MYO3B	1071	Q8WXR4
SAWRGYDARRKFKKI	MYO3B	1096	Q8WXR4
SKARGKDRLWSHTRE	MYO7A	1736	Q13402
FGRRWTKISKLIGSR	MYSM1	136	Q5VVJ2