Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	bitter taste receptor activity	TAS2R31 TAS2R43 TAS2R33	7.06e-06	27	28	3	GO:0033038
GeneOntologyMolecularFunction	taste receptor activity	TAS2R31 TAS2R43 TAS2R33	1.31e-05	33	28	3	GO:0008527
GeneOntologyMolecularFunction	phospholipase activity	PLCB2 PNPLA6 DDHD1	5.35e-04	114	28	3	GO:0004620
GeneOntologyMolecularFunction	metalloaminopeptidase activity	RNPEP ERAP2	6.04e-04	26	28	2	GO:0070006
GeneOntologyMolecularFunction	lipase activity	PLCB2 PNPLA6 DDHD1	9.32e-04	138	28	3	GO:0016298
GeneOntologyMolecularFunction	aminopeptidase activity	RNPEP ERAP2	1.65e-03	43	28	2	GO:0004177
GeneOntologyMolecularFunction	metallopeptidase activity	RNPEP PITRM1 ERAP2	2.70e-03	200	28	3	GO:0008237
GeneOntologyMolecularFunction	metalloexopeptidase activity	RNPEP ERAP2	4.32e-03	70	28	2	GO:0008235
GeneOntologyMolecularFunction	G protein-coupled receptor activity	TAS2R31 TAS2R43 TAS2R33 OPRK1 OR10V1	7.07e-03	884	28	5	GO:0004930
GeneOntologyBiologicalProcess	sensory perception of taste	PLCB2 TAS2R31 TAS2R43 ASIC1 TAS2R33	3.60e-08	70	28	5	GO:0050909
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of bitter taste	PLCB2 TAS2R31 TAS2R43 TAS2R33	3.55e-07	44	28	4	GO:0001580
GeneOntologyBiologicalProcess	sensory perception of bitter taste	PLCB2 TAS2R31 TAS2R43 TAS2R33	5.07e-07	48	28	4	GO:0050913
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of taste	PLCB2 TAS2R31 TAS2R43 TAS2R33	5.99e-07	50	28	4	GO:0050912
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	PLCB2 TAS2R31 TAS2R43 ASIC1 TAS2R33 OR10V1	7.75e-05	547	28	6	GO:0007606
GeneOntologyBiologicalProcess	detection of stimulus	PLCB2 TAS2R31 TAS2R43 TAS2R33 PARG OR10V1	3.51e-04	722	28	6	GO:0051606
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	PLCB2 TAS2R31 TAS2R43 TAS2R33 OR10V1	4.42e-04	485	28	5	GO:0050907
GeneOntologyBiologicalProcess	sensory perception	PLCB2 TAS2R31 TAS2R43 ASIC1 TAS2R33 OPRK1 OR10V1	4.54e-04	1072	28	7	GO:0007600
GeneOntologyBiologicalProcess	detection of chemical stimulus	PLCB2 TAS2R31 TAS2R43 TAS2R33 OR10V1	6.29e-04	524	28	5	GO:0009593
Domain	Peptidase_M1	RNPEP ERAP2	1.22e-04	12	26	2	IPR001930
Domain	Peptidase_M1	RNPEP ERAP2	1.44e-04	13	26	2	PF01433
Domain	Peptidase_M1_N	RNPEP ERAP2	1.44e-04	13	26	2	IPR014782
Domain	TAS2R	TAS2R31 TAS2R43	5.93e-04	26	26	2	PF05296
Domain	T2R	TAS2R31 TAS2R43	5.93e-04	26	26	2	IPR007960
Domain	ZINC_PROTEASE	RNPEP ERAP2	8.16e-03	98	26	2	PS00142
Pathway	REACTOME_SENSORY_PERCEPTION_OF_TASTE	PLCB2 TAS2R31 TAS2R43	5.87e-05	47	23	3	M42524
Pathway	KEGG_TASTE_TRANSDUCTION	PLCB2 TAS2R31 TAS2R43	7.96e-05	52	23	3	M5785
Pubmed	Bitter taste receptors for saccharin and acesulfame K.	TAS2R31 TAS2R43	6.71e-07	2	29	2	15537898
Pubmed	Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin.	TAS2R31 TAS2R43	6.71e-07	2	29	2	17702579
Pubmed	Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.	PLCB2 TAS2R31 TAS2R43	1.50e-06	27	29	3	12581520
Pubmed	The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.	TAS2R31 TAS2R43	4.41e-05	12	29	2	12379855
Pubmed	Haplotypes at the Tas2r locus on distal chromosome 6 vary with quinine taste sensitivity in inbred mice.	TAS2R31 TAS2R43	5.21e-05	13	29	2	15938754
Pubmed	Identification and characterization of human taste receptor genes belonging to the TAS2R family.	TAS2R31 TAS2R43	5.21e-05	13	29	2	12584440
Pubmed	The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.	DIO1 ILF2	9.06e-05	17	29	2	23502783
Pubmed	A novel family of mammalian taste receptors.	TAS2R31 TAS2R43	1.40e-04	21	29	2	10761934
Pubmed	Evolutionary relationships of the Tas2r receptor gene families in mouse and human.	TAS2R31 TAS2R43	1.53e-04	22	29	2	12734386
Pubmed	The molecular receptive ranges of human TAS2R bitter taste receptors.	TAS2R31 TAS2R43	1.68e-04	23	29	2	20022913
Pubmed	Receptors for bitter and sweet taste.	TAS2R31 TAS2R43	1.99e-04	25	29	2	12139982
Pubmed	Molecular mechanisms of bitter and sweet taste transduction.	TAS2R31 TAS2R43	2.15e-04	26	29	2	11696554
Pubmed	Identification of genes controlled by LMX1B in E13.5 mouse limbs.	SLITRK1 OPRK1	2.15e-04	26	29	2	20589901
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	EML5 TTLL6 BCO1	2.75e-04	152	29	3	34299191
Pubmed	Adaptive diversification of bitter taste receptor genes in Mammalian evolution.	TAS2R31 TAS2R43	2.88e-04	30	29	2	12679530
Pubmed	Methylation of the DNA/RNA-binding protein Kin17 by METTL22 affects its association with chromatin.	RPL14 ILF2	2.88e-04	30	29	2	24140279
Pubmed	Mapping of QTLs for oral alcohol self-administration in B6.C and B6.I quasi-congenic RQI strains.	TAS2R31 TAS2R43	2.88e-04	30	29	2	17273929
Pubmed	Evolution of bitter taste receptors in humans and apes.	TAS2R31 TAS2R43	3.70e-04	34	29	2	15496549
Pubmed	The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins.	RPL14 RNPEP PITRM1	6.40e-04	203	29	3	35012549
Cytoband	12p13.2	TAS2R31 TAS2R43	3.49e-04	45	28	2	12p13.2
Cytoband	12q12	ASIC1 TMEM117	3.81e-04	47	28	2	12q12
GeneFamily	Taste 2 receptors	TAS2R31 TAS2R43 TAS2R33	8.78e-06	39	19	3	1162
GeneFamily	Aminopeptidases\|CD molecules	RNPEP ERAP2	1.41e-04	17	19	2	104
Drug	acesulfame-K	PLCB2 TAS2R31 TAS2R43 OPRK1	8.74e-09	20	28	4	CID000036573
Drug	saccharin	PLCB2 TAS2R31 TAS2R43 OPRK1	5.55e-07	54	28	4	CID000005143
Drug	NDTMB	RNPEP OPRK1	3.05e-05	7	28	2	CID000134748
Disease	Spastic Paraplegia, Hereditary	PNPLA6 DDHD1	6.23e-05	14	25	2	C0037773
Disease	congenital heart disease (implicated_via_orthology)	PLCB2 RPL14	1.56e-03	69	25	2	DOID:1682 (implicated_via_orthology)
Disease	multiple myeloma	DIO1 ILF2	4.05e-03	112	25	2	EFO_0001378

Protein segments in the cluster

Peptide	Gene	Start	Entry
EKRGPNKFFFQMCQP	RNPEP	211	Q9H4A4
SEFRFLKRFMPNFPF	PCDHB1	766	Q9Y5F3
PVDKMCKFLRFFFNP	CFAP99	111	D6REC4
PPIDCFKTMDFGKFD	PNPLA6	1226	Q8IY17
KTAKMQFFFRPFSPD	OR10V1	6	Q8NGI7
AVKIFPRFFMVAKQC	LY6K	71	Q17RY6
RFLLEEPMPFFYLKC	LY6K	101	Q17RY6
NAFFCTFPRRNAKMK	PARG	636	Q86W56
UPSFMFKFDQFKRLI	DIO1	126	P49895
GMKCLFRISFFPKDP	FRMPD3	256	Q5JV73
PSLLKTFKPFFVDFM	CPAMD8	796	Q8IZJ3
PFDFYLCEMAFPRVK	ILF2	31	Q12905
MAFPCFDEPLFKANF	ERAP2	206	Q6P179
GMVKLFDFPCPEKFA	EML5	1911	Q05BV3
FDFPCPEKFAKHKRF	EML5	1916	Q05BV3
LKFKVENFFCMGSPL	DDHD1	611	Q8NEL9
NFKRCFRDFCFPLKM	OPRK1	336	P41145
ENKPVFMFCKAIRFS	TAS2R31	256	P59538
ENKPVFMFCKAIRFS	TAS2R33	256	P0DSN6
ENKPVFMFCKAIRFS	TAS2R43	256	P59537
LKFCEFPQKTIMPGF	TDRD6	1291	O60522
KYPCRDPFFKMLNRS	PITRM1	116	Q5JRX3
MAYPDPCKNIFSKAF	BCO1	96	Q9HAY6
KANFRSFKPKPFNMR	ASIC1	141	P78348
SFKPKPFNMREFYDR	ASIC1	146	P78348
LKCETPVNFFRKDFM	SLITRK1	556	Q96PX8
PFKCMQLTDFILKFP	RPL14	51	P50914
MLKMFPKDFRFFPRT	TTLL6	136	Q8N841
GPCKAIMKRFFFNIF	TFPI	61	P10646
PVKNFFQMFPADRKR	PLCB2	166	Q00722
TPHMQFKIPFFQKIF	TMEM117	276	Q9H0C3
MCIIFFKFDPRPVSK	TANGO2	1	Q6ICL3