Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
HumanPheno	Abnormal cell morphology	WEE2 TINF2 RTEL1	4.54e-05	43	9	3	HP:0025461
Domain	-	GBA3 HEXD	3.07e-03	35	44	2	3.20.20.80
Domain	Glyco_hydro_catalytic_dom	GBA3 HEXD	3.61e-03	38	44	2	IPR013781
Domain	fn3	VWA1 IGDCC4 MYOM3	6.54e-03	162	44	3	PF00041
Domain	Glycoside_hydrolase_SF	GBA3 HEXD	6.93e-03	53	44	2	IPR017853
Domain	FN3	VWA1 IGDCC4 MYOM3	9.40e-03	185	44	3	SM00060
Domain	Ig_I-set	SIGLEC1 IGDCC4 MYOM3	1.01e-02	190	44	3	IPR013098
Domain	I-set	SIGLEC1 IGDCC4 MYOM3	1.01e-02	190	44	3	PF07679
Domain	FN3	VWA1 IGDCC4 MYOM3	1.15e-02	199	44	3	PS50853
Pubmed	Structures of UBA6 explain its dual specificity for ubiquitin and FAT10.	UBA6 UBE2Z	1.64e-06	2	45	2	35970836
Pubmed	Pulmonary fibrosis in dyskeratosis congenita: a case report with a PRISMA-compliant systematic review.	TINF2 RTEL1	4.91e-06	3	45	2	34479523
Pubmed	Investigations into the auto-FAT10ylation of the bispecific E2 conjugating enzyme UBA6-specific E2 enzyme 1.	UBA6 UBE2Z	9.81e-06	4	45	2	24528925
Pubmed	Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system.	UBA6 UBE2Z	9.81e-06	4	45	2	23499007
Pubmed	LMO2 blocks the UBA6-USE1 interaction and downstream FAT10ylation by targeting the ubiquitin fold domain of UBA6.	UBA6 UBE2Z	1.63e-05	5	45	2	27569286
Pubmed	New mutations in ZFPM2/FOG2 gene in tetralogy of Fallot and double outlet right ventricle.	GATA4 GDF1	1.63e-05	5	45	2	20807224
Pubmed	TRF2 recruits RTEL1 to telomeres in S phase to promote t-loop unwinding.	TINF2 RTEL1	2.45e-05	6	45	2	25620558
Pubmed	USE1 is a bispecific conjugating enzyme for ubiquitin and FAT10, which FAT10ylates itself in cis.	UBA6 UBE2Z	2.45e-05	6	45	2	20975683
Pubmed	Mechanistic studies on activation of ubiquitin and di-ubiquitin-like protein, FAT10, by ubiquitin-like modifier activating enzyme 6, Uba6.	UBA6 UBE2Z	2.45e-05	6	45	2	22427669
Pubmed	The ubiquitin-like modifier FAT10 stimulates the activity of deubiquitylating enzyme OTUB1.	UBA6 UBE2Z	3.42e-05	7	45	2	30718280
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	HOXA9 RTEL1 DTX1 IGDCC4	4.54e-05	152	45	4	34299191
Pubmed	Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives.	GPR135 RXFP4	4.56e-05	8	45	2	14623098
Pubmed	The ubiquitin-like modifier FAT10 interferes with SUMO activation.	UBA6 UBE2Z	4.56e-05	8	45	2	31575873
Pubmed	Pulmonary Fibrosis Predisposition Overview	TINF2 RTEL1	1.27e-04	13	45	2	20301408
Pubmed	Tet proteins influence the balance between neuroectodermal and mesodermal fate choice by inhibiting Wnt signaling.	SOX1 GATA4	1.70e-04	15	45	2	27930333
Pubmed	Dyskeratosis Congenita and Related Telomere Biology Disorders	TINF2 RTEL1	1.94e-04	16	45	2	20301779
Pubmed	Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment.	SOX1 GATA4	2.20e-04	17	45	2	20573702
Pubmed	Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs.	SOX1 GATA4	2.76e-04	19	45	2	35988542
Pubmed	Embryo model completes gastrulation to neurulation and organogenesis.	SOX1 GATA4	3.72e-04	22	45	2	36007540
Pubmed	E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification.	UBA6 UBE2Z	4.07e-04	23	45	2	19250909
Pubmed	HBO1 is required for H3K14 acetylation and normal transcriptional activity during embryonic development.	SOX1 GATA4	4.44e-04	24	45	2	21149574
Pubmed	Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging.	UBA6 UBE2Z	4.82e-04	25	45	2	17597759
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	GATA4 HOXA9 RAB11FIP5 ZBTB7A SIGLEC1 SURF6 CPEB4	5.37e-04	1116	45	7	31753913
Pubmed	STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells.	SOX1 GATA4	1.00e-03	36	45	2	33230114
Cytoband	7q36.1	TMEM176A ASB10	2.43e-03	74	45	2	7q36.1
Computational	Genes in the cancer module 136.	SOX1 ZBTB7A LMTK3 ARHGAP45 SURF6 AGAP2	2.66e-04	491	21	6	MODULE_136
Computational	Genes in the cancer module 69.	SOX1 ZBTB7A LMTK3 ARHGAP45 SURF6 AGAP2	3.86e-04	526	21	6	MODULE_69
Disease	Dyskeratosis congenita	TINF2 RTEL1	7.77e-05	9	44	2	cv:C0265965
Disease	HOYERAAL-HREIDARSSON SYNDROME	TINF2 RTEL1	9.71e-05	10	44	2	C1846142
Disease	CD209 antigen measurement	SLC2A6 SURF6	1.96e-04	14	44	2	EFO_0008077
Disease	Tetralogy of Fallot	GATA4 GDF1	2.57e-04	16	44	2	C0039685
Disease	Dyskeratosis Congenita	TINF2 RTEL1	2.57e-04	16	44	2	C0265965
Disease	a disintegrin and metalloproteinase with thrombospondin motifs 13 measurement	SLC2A6 SURF6	2.91e-04	17	44	2	EFO_0008011
Disease	congenital heart disease (is_implicated_in)	GATA4 GDF1	5.87e-04	24	44	2	DOID:1682 (is_implicated_in)
Disease	total blood protein measurement	TMEM176A ZBTB7A SIGLEC1 ARHGAP45	4.44e-03	449	44	4	EFO_0004536
Disease	Alcohol abuse	GATA4 GALR3	4.52e-03	67	44	2	C0085762

Protein segments in the cluster

Peptide	Gene	Start	Entry
GVPAWVSNGDAADAA	ARHGEF10L	86	Q9HCE6
PFAAAGALQGWSLGS	CCR10	96	P46092
ASGPALAFWQAVLAG	ASB10	51	Q8WXI3
HPEGGASWLSTAANF	ARMC1	261	Q9NVT9
AGAPDAKFSGWADAV	AGAP2	461	Q99490
AAAEARGPGFWDAFA	C1orf232	101	A0A0U1RR37
ISAGTAAGFGAPSQW	IGDCC4	601	Q8TDY8
ADAGPAPWAASSAAA	RAB11FIP5	91	Q9BXF6
TGWAAFAAKTSSAGP	INTS12	291	Q96CB8
HASAAGFPLSGAASW	ARHGAP45	71	Q92619
AIGPWSALAGFADVL	MAGEC3	301	Q8TD91
GAALWEAGSPVAFYA	MMRN2	816	Q9H8L6
FAAAAAAAPEGGWEL	GDF1	151	P27539
PAQSSASGSFLLSGW	LMTK3	596	Q96Q04
TVFGASWNPVHAAGA	HOXA9	61	P31269
FPQLWAASAFKGATG	HEXD	246	Q8WVB3
ASWFGSVFTLGAAAG	SLC2A6	81	Q9UGQ3
ATFTGAALWAAPAAG	DTX1	251	Q86Y01
LWAAVGPAGAAAAEA	GALR3	211	O60755
ASWAAAAAASAGPFD	GATA4	171	P43694
SAPAAAAGPWRGFCA	GPR135	171	Q8IZ08
MAFPAGFGWAAATAA	GBA3	1	Q9H227
ANGSSAGSAWLFPAP	CPEB4	51	Q17RY0
AWGAAAATEIPDFAS	B3GNT8	96	Q7Z7M8
ALSFLWPAGGAAATG	IRGQ	576	Q8WZA9
LSSWGNAAAAAGDPI	RTEL1	86	Q9NZ71
PTFFWANASGGSVLS	RXFP4	11	Q8TDU9
VSWGLRAAAAGGAFP	SORT1	56	Q99523
SASEAAPAAAALFAW	SERGEF	6	Q9UGK8
ALAWSGPALGNSLAA	SIGLEC15	196	Q6ZMC9
WTGAVAVLAGAAAFI	TMEM176A	91	Q96HP8
FWPGQSAADILSGAA	POFUT2	26	Q9Y2G5
AWASSSAGNPADGLA	SURF6	91	O75683
SALGAGLLNFPWAFS	SLC38A8	36	A6NNN8
GWANGAYPGSVAAAA	SOX1	186	O00570
SWAPALGSAAALGYH	VWA1	351	Q6PCB0
WTAQGFLSPLAAAVG	UBA6	381	A0AVT1
VAGGFAGIASWVAAT	SLC25A45	206	Q8N413
VAGPAALRFAAAASW	TINF2	6	Q9BSI4
ASFFPAGQASWGVSS	SIGLEC1	11	Q9BZZ2
FLPDVWAAAAAAGGA	UBE2Z	41	Q9H832
VAAGAESLPTNGAAW	WEE2	426	P0C1S8
AAAAAASFPWSAFGA	ZBTB7A	176	O95365
WADGKGPLAAAFSSS	ZW10	741	O43264
AANWAGVGELSAPSS	MYOM3	776	Q5VTT5