Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent activity	RAD51D HSPA4L ABCA13 NVL RNF213 DHX57 ACSF2 DNAH7 DNAH14 DDX11 CCT8L2 UBA7 CLPB ABCB8 HELZ2 NAV2 ABCB11 CCT8L1P POLQ	9.50e-08	614	144	19	GO:0140657
GeneOntologyMolecularFunction	nuclear import signal receptor activity	KPNA4 KPNA5 HIKESHI KPNA3	1.15e-05	20	144	4	GO:0061608
GeneOntologyMolecularFunction	ATP hydrolysis activity	RAD51D ABCA13 NVL RNF213 DHX57 DNAH7 DDX11 CLPB ABCB8 HELZ2 NAV2 ABCB11 POLQ	1.91e-05	441	144	13	GO:0016887
GeneOntologyMolecularFunction	nucleocytoplasmic carrier activity	KPNA4 KPNA5 HIKESHI KPNA3	7.97e-05	32	144	4	GO:0140142
GeneOntologyMolecularFunction	RNA uridylyltransferase activity	TUT4 TUT1	1.54e-04	3	144	2	GO:0050265
GeneOntologyMolecularFunction	cadherin binding	CTNNAL1 CDHR3 SPTBN1 SPTBN2 OBSCN OLFM4 DIAPH3 CDH5 NOS3 NOTCH3	1.79e-04	339	144	10	GO:0045296
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IMPDH2 LDHAL6B CBR1 CBR3 PTGR3 HSD17B14	3.20e-04	127	144	6	GO:0016616
GeneOntologyMolecularFunction	cell adhesion molecule binding	CTNNAL1 CDHR3 SPTBN1 SPTBN2 OBSCN OLFM4 LAMB2 ITGAM DST DIAPH3 CDH5 NOS3 NOTCH3	4.06e-04	599	144	13	GO:0050839
GeneOntologyMolecularFunction	oxidoreductase activity, acting on CH-OH group of donors	IMPDH2 LDHAL6B CBR1 CBR3 PTGR3 HSD17B14	4.99e-04	138	144	6	GO:0016614
GeneOntologyMolecularFunction	ankyrin binding	SPTBN1 OBSCN SPTBN4	5.85e-04	23	144	3	GO:0030506
GeneOntologyMolecularFunction	nuclear localization sequence binding	KPNA4 KPNA5 KPNA3	9.46e-04	27	144	3	GO:0008139
GeneOntologyMolecularFunction	uridylyltransferase activity	TUT4 TUT1	1.06e-03	7	144	2	GO:0070569
GeneOntologyCellularComponent	spectrin	SPTBN1 SPTBN2 SPTBN4	2.72e-05	9	146	3	GO:0008091
GeneOntologyCellularComponent	NLS-dependent protein nuclear import complex	KPNA4 KPNA5 KPNA3	3.86e-05	10	146	3	GO:0042564
GeneOntologyCellularComponent	nucleocytoplasmic transport complex	KPNA4 KPNA5 KPNA3	7.01e-05	12	146	3	GO:0031074
GeneOntologyCellularComponent	anchoring junction	HSPG2 PDGFRB CDHR3 SPTBN2 OBSCN MPDZ BCAR1 PTK7 SPTBN4 MAGI2 DST XIRP2 ARHGAP31 CSPG4 CNTNAP2 ABCB11 STX16 CDH5	1.61e-04	976	146	18	GO:0070161
MousePheno	decreased kidney cell proliferation	FAT4 PDGFRB PKHD1 NOS3	4.77e-07	9	112	4	MP:0011441
MousePheno	abnormal kidney cell proliferation	FAT4 PDGFRB PKD1 PKHD1 NOS3	1.74e-06	26	112	5	MP:0011439
Domain	AAA	RAD51D ABCA13 NVL RNF213 DNAH7 CLPB ABCB8 HELZ2 NAV2 ABCB11	1.32e-07	144	140	10	SM00382
Domain	AAA+_ATPase	RAD51D ABCA13 NVL RNF213 DNAH7 CLPB ABCB8 HELZ2 NAV2 ABCB11	1.32e-07	144	140	10	IPR003593
Domain	Spectrin	KALRN SPTBN1 SPTBN2 SPTBN4 DST	6.65e-07	23	140	5	PF00435
Domain	Spectrin_bsu	SPTBN1 SPTBN2 SPTBN4	1.64e-06	4	140	3	IPR016343
Domain	ARM-type_fold	KPNA4 KPNA5 RALGAPA1 DNAJC13 CLTCL1 USP9X INTS1 URB1 AP2A1 DIAPH3 TAF6 HEATR5B KPNA3	1.67e-06	339	140	13	IPR016024
Domain	Spectrin_repeat	KALRN SPTBN1 SPTBN2 SPTBN4 DST	2.26e-06	29	140	5	IPR002017
Domain	SPEC	KALRN SPTBN1 SPTBN2 SPTBN4 DST	3.77e-06	32	140	5	SM00150
Domain	Spectrin/alpha-actinin	KALRN SPTBN1 SPTBN2 SPTBN4 DST	3.77e-06	32	140	5	IPR018159
Domain	LAM_G_DOMAIN	HSPG2 FAT4 FAT3 CSPG4 CNTNAP2	9.06e-06	38	140	5	PS50025
Domain	Laminin_G_2	HSPG2 FAT4 FAT3 CSPG4 CNTNAP2	1.17e-05	40	140	5	PF02210
Domain	Arm_3	KPNA4 KPNA5 KPNA3	1.41e-05	7	140	3	PF16186
Domain	Importing_su_alpha	KPNA4 KPNA5 KPNA3	1.41e-05	7	140	3	IPR024931
Domain	IBB	KPNA4 KPNA5 KPNA3	1.41e-05	7	140	3	PF01749
Domain	Arm_3	KPNA4 KPNA5 KPNA3	1.41e-05	7	140	3	IPR032413
Domain	LamG	HSPG2 FAT4 FAT3 CSPG4 CNTNAP2	1.89e-05	44	140	5	SM00282
Domain	IBB	KPNA4 KPNA5 KPNA3	2.25e-05	8	140	3	PS51214
Domain	ACTININ_2	SPTBN1 SPTBN2 SPTBN4 DST	2.40e-05	23	140	4	PS00020
Domain	ACTININ_1	SPTBN1 SPTBN2 SPTBN4 DST	2.40e-05	23	140	4	PS00019
Domain	Actinin_actin-bd_CS	SPTBN1 SPTBN2 SPTBN4 DST	2.40e-05	23	140	4	IPR001589
Domain	PH_dom-spectrin-type	SPTBN1 SPTBN2 SPTBN4	3.35e-05	9	140	3	IPR001605
Domain	Importin-a_IBB	KPNA4 KPNA5 KPNA3	3.35e-05	9	140	3	IPR002652
Domain	Laminin_G	HSPG2 FAT4 FAT3 CSPG4 CNTNAP2	7.34e-05	58	140	5	IPR001791
Domain	-	HSPG2 FAT4 FAT3 ADGRV1 CSPG4 CNTNAP2	8.01e-05	95	140	6	2.60.120.200
Domain	CH	SPTBN1 SPTBN2 SPTBN4 DST NAV2	1.27e-04	65	140	5	SM00033
Domain	-	RAD51D ABCA13 NVL RNF213 DHX57 AAGAB DNAH7 DNAH14 DDX11 CLPB ABCB8 HELZ2 NAV2 ABCB11 POLQ AGAP2	1.51e-04	746	140	16	3.40.50.300
Domain	CH	SPTBN1 SPTBN2 SPTBN4 DST NAV2	1.80e-04	70	140	5	PF00307
Domain	-	SPTBN1 SPTBN2 SPTBN4 DST NAV2	1.93e-04	71	140	5	1.10.418.10
Domain	P-loop_NTPase	RAD51D ABCA13 NVL RNF213 DHX57 AAGAB DNAH7 DNAH14 DDX11 MAGI2 CLPB ABCB8 HELZ2 NAV2 ABCB11 POLQ AGAP2	2.08e-04	848	140	17	IPR027417
Domain	CH	SPTBN1 SPTBN2 SPTBN4 DST NAV2	2.20e-04	73	140	5	PS50021
Domain	CH-domain	SPTBN1 SPTBN2 SPTBN4 DST NAV2	2.50e-04	75	140	5	IPR001715
Domain	-	KPNA4 KPNA5 DNAJC13 USP9X AP2A1 TAF6 HEATR5B KPNA3	2.74e-04	222	140	8	1.25.10.10
Domain	ARM-like	KPNA4 KPNA5 DNAJC13 USP9X AP2A1 TAF6 HEATR5B KPNA3	9.93e-04	270	140	8	IPR011989
Domain	PKD	SORCS1 PKD1	1.14e-03	7	140	2	PF00801
Domain	PAP_assoc	TUT4 TUT1	1.14e-03	7	140	2	PF03828
Domain	PAP_assoc	TUT4 TUT1	1.14e-03	7	140	2	IPR002058
Domain	ConA-like_dom	HSPG2 FAT4 FAT3 ADGRV1 CSPG4 CNTNAP2 BTNL9	1.33e-03	219	140	7	IPR013320
Domain	Arm	KPNA4 KPNA5 KPNA3	1.59e-03	31	140	3	PF00514
Domain	-	LDHAL6B CBR1 CBR3 PTGR3 UBA7 HSD17B14	1.74e-03	169	140	6	3.40.50.720
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	KPNA4 RALGAPA1 DNAJC13 CTNNAL1 CCDC22 USP9X POLR2B SPTBN1 SPTBN2 KIAA1549 RNF213 PFDN2 SIX4 BCAR1 TOX4 AKAP9 SSH3 ALDH18A1 STX16 PPP1R12C KPNA3	3.31e-09	1049	146	21	27880917
Pubmed	A protein interaction landscape of breast cancer.	KPNA4 RAD51D IMPDH2 HSPA4L FXR2 USP9X SPTBN2 ETF1 SIPA1 CBR1 TOX4 DST AP2A1 NAV2 ALDH18A1 KPNA3	1.20e-08	634	146	16	34591612
Pubmed	Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin.	KALRN SPTBN1 SPTBN2 SPTBN4	9.61e-08	11	146	4	17607528
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	KPNA4 HEXB KALRN PDGFRB USP9X SPTBN1 SPTBN2 PFDN2 CBR1 CBR3 SPTBN4 MAGI2 UBA7 DST AP2A1 CLPB PKD1 TMEM131 TAF6 AGAP2 KPNA3	1.06e-07	1285	146	21	35914814
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	HEXB RALGAPA1 DNAJC13 KALRN HSPA4L IGHV1-69 USP9X SPTBN1 SPTBN2 ETF1 KIAA1549 DHX57 SIPA1 CBR1 IGHV1-69D SPTBN4 MAGI2 DST AP2A1 PPP1R12C AGAP2 KPNA3	1.47e-07	1431	146	22	37142655
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	KPNA4 CLTCL1 HSPA4L PTBP2 STRBP SPTBN1 SPTBN2 BEND3 DHX57 PTK7 CAPN11 DDX11 SPTBN4 DST AP2A1 CSPG4 PKHD1 NAV2 DIAPH3 POLQ BTNL9 AGAP2	1.68e-07	1442	146	22	35575683
Pubmed	PRELP secreted from mural cells protects the function of blood brain barrier through regulation of endothelial cell-cell integrity.	HSPG2 PDGFRB CSPG4 CDH5	2.07e-07	13	146	4	37936982
Pubmed	Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family.	KPNA4 KPNA5 KPNA3	2.89e-07	4	146	3	9395085
Pubmed	Inhibition of HIV-1 integrase nuclear import and replication by a peptide bearing integrase putative nuclear localization signal.	KPNA4 KPNA5 KPNA3	7.20e-07	5	146	3	19961612
Pubmed	Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite.	KPNA4 KPNA5 KPNA3	7.20e-07	5	146	3	17981117
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	IMPDH2 FXR2 STRBP USP9X SPTBN1 SPTBN2 INTS1 NVL BEND3 DHX57 URB1 DST HELZ2 ALDH18A1	7.30e-07	653	146	14	22586326
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	SPTBN2 KIAA1549 SPTBN4 MAGI2 DST AARS2 CNTNAP2	1.36e-06	130	146	7	12421765
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	KPNA4 HSPA4L USP9X POLR2B SPTBN1 SPTBN2 ETF1 OBSCN DHX57 CBR3 XIRP2 NAV2	1.39e-06	497	146	12	36774506
Pubmed	Functional proteomics mapping of a human signaling pathway.	HSPG2 SPTBN1 LAMB2 PIGQ TOX4 DST AP2A1 CLPB TBC1D1 CSPG4 PKD1 DIAPH3 STX16	1.40e-06	591	146	13	15231748
Pubmed	Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import.	KPNA4 KPNA5 KPNA3	1.44e-06	6	146	3	8551560
Pubmed	p17 and p17-containing gag precursors of input human immunodeficiency virus are transported into the nuclei of infected cells.	KPNA4 KPNA5 KPNA3	1.44e-06	6	146	3	2064827
Pubmed	Backbone cyclic peptide, which mimics the nuclear localization signal of human immunodeficiency virus type 1 matrix protein, inhibits nuclear import and virus production in nondividing cells.	KPNA4 KPNA5 KPNA3	1.44e-06	6	146	3	9548947
Pubmed	The putative alpha helix 2 of human immunodeficiency virus type 1 Vpr contains a determinant which is responsible for the nuclear translocation of proviral DNA in growth-arrested cells.	KPNA4 KPNA5 KPNA3	1.44e-06	6	146	3	9557700
Pubmed	A role for human immunodeficiency virus type 1 Vpr during infection of peripheral blood mononuclear cells.	KPNA4 KPNA5 KPNA3	1.44e-06	6	146	3	9603322
Pubmed	CNI-H0294, a nuclear importation inhibitor of the human immunodeficiency virus type 1 genome, abrogates virus replication in infected activated peripheral blood mononuclear cells.	KPNA4 KPNA5 KPNA3	1.44e-06	6	146	3	9593140
Pubmed	HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase.	KPNA4 KPNA5 KPNA3	1.44e-06	6	146	3	7585960
Pubmed	The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.	KPNA4 KPNA5 KPNA3	1.44e-06	6	146	3	8041786
Pubmed	The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes.	KPNA4 KPNA5 KPNA3	1.44e-06	6	146	3	8041734
Pubmed	HIV-1 infection of non-dividing cells: evidence that the amino-terminal basic region of the viral matrix protein is important for Gag processing but not for post-entry nuclear import.	KPNA4 KPNA5 KPNA3	1.44e-06	6	146	3	9303297
Pubmed	Inhibition of nuclear import by backbone cyclic peptidomimetics derived from the HIV-1 MA NLS sequence.	KPNA4 KPNA5 KPNA3	1.44e-06	6	146	3	11904219
Pubmed	Phenotype of HIV-1 lacking a functional nuclear localization signal in matrix protein of gag and Vpr is comparable to wild-type HIV-1 in primary macrophages.	KPNA4 KPNA5 KPNA3	1.44e-06	6	146	3	9918876
Pubmed	HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator.	KPNA4 KPNA5 KPNA3	1.44e-06	6	146	3	7859280
Pubmed	Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention.	KPNA4 KPNA5 KPNA3	1.44e-06	6	146	3	8529100
Pubmed	Phosphorylation of residue 131 of HIV-1 matrix is not required for macrophage infection.	KPNA4 KPNA5 KPNA3	1.44e-06	6	146	3	9008157
Pubmed	A synthetic peptide bearing the HIV-1 integrase 161-173 amino acid residues mediates active nuclear import and binding to importin alpha: characterization of a functional nuclear localization signal.	KPNA4 KPNA5 KPNA3	1.44e-06	6	146	3	15037073
Pubmed	Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation.	KPNA4 KPNA5 KPNA3	1.44e-06	6	146	3	8876228
Pubmed	Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection.	KPNA4 KPNA5 KPNA3	1.44e-06	6	146	3	7745752
Pubmed	Evidence for direct association of Vpr and matrix protein p17 within the HIV-1 virion.	KPNA4 KPNA5 KPNA3	1.44e-06	6	146	3	8659115
Pubmed	Spectrins and ankyrinB constitute a specialized paranodal cytoskeleton.	SPTBN2 SPTBN4 CNTNAP2	1.44e-06	6	146	3	16687515
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	RALGAPA1 HSPA4L FXR2 USP9X GTF2A1 TOX4 DST CLPB	1.99e-06	197	146	8	20811636
Pubmed	Active nuclear import and cytoplasmic retention of activation-induced deaminase.	KPNA4 KPNA5 KPNA3	2.51e-06	7	146	3	19412186
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	CCDC22 CLTCL1 IMPA2 IMPDH2 PSMG3 HSPA4L FXR2 STRBP POLR2B SPTBN1 SPTBN2 RNF213 DHX57 URB1 DST AARS2 CLPB ALDH18A1 STX16 KPNA3	2.72e-06	1440	146	20	30833792
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	FAT4 MXRA5 FXR2 SPTBN2 INTS1 OBSCN RNF213 OIP5 DNAH14 URB1 DST PKD1 PKHD1 ALDH18A1	2.95e-06	736	146	14	29676528
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DNAJC13 IMPDH2 KALRN FXR2 USP9X SPTBN1 SPTBN2 ETF1 MPDZ SIPA1 SPTBN4 MAGI2 DST AKAP9 AP2A1 AGAP2	3.19e-06	963	146	16	28671696
Pubmed	An actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-A.	KPNA4 KPNA5 KPNA3	4.00e-06	8	146	3	20818336
Pubmed	Blocking nuclear import of pre-integration complex: an emerging anti-HIV-1 drug discovery paradigm.	KPNA4 KPNA5 KPNA3	4.00e-06	8	146	3	20015032
Pubmed	Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA.	KPNA4 KPNA5 KPNA3	4.00e-06	8	146	3	8552640
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	HMBOX1 RALGAPA1 DNAJC13 TUT4 IMPA2 PTBP2 OBSCN SREBF2 RNF213 ADGRV1 BCAR1 DNAH14 PTK7 SPTBN4 OR51E2 SLC41A3 TBC1D1 NAXD HSD17B14 NOTCH3	4.48e-06	1489	146	20	28611215
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	KPNA4 IMPDH2 POLR2B INTS1 MPDZ LAMB2 DHX57 SIX4 RSBN1 URB1 GTF2H4 DST CLPB HELZ2 ALDH18A1 TAF6 HEATR5B STX16 PPP1R12C KPNA3	4.85e-06	1497	146	20	31527615
Pubmed	HIV-1 nuclear import: in search of a leader.	KPNA4 KPNA5 KPNA3	5.98e-06	9	146	3	10525473
Pubmed	HIV-1 infection requires a functional integrase NLS.	KPNA4 KPNA5 KPNA3	5.98e-06	9	146	3	11389849
Pubmed	Viral protein R regulates nuclear import of the HIV-1 pre-integration complex.	KPNA4 KPNA5 KPNA3	5.98e-06	9	146	3	9463369
Pubmed	Reassessment of the roles of integrase and the central DNA flap in human immunodeficiency virus type 1 nuclear import.	KPNA4 KPNA5 KPNA3	5.98e-06	9	146	3	12414950
Pubmed	14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1).	KPNA4 KPNA5 KPNA3	5.98e-06	9	146	3	15057270
Pubmed	Nuclear localization of human immunodeficiency virus type 1 integrase expressed as a fusion protein with green fluorescent protein.	KPNA4 KPNA5 KPNA3	5.98e-06	9	146	3	10366569
Pubmed	HIV-1 nuclear import: in search of a leader.	KPNA4 KPNA5 KPNA3	5.98e-06	9	146	3	9366553
Pubmed	Two nuclear localization signals in the HIV-1 matrix protein regulate nuclear import of the HIV-1 pre-integration complex.	KPNA4 KPNA5 KPNA3	5.98e-06	9	146	3	10860744
Pubmed	Nuclear localization of human immunodeficiency virus type 1 preintegration complexes (PICs): V165A and R166A are pleiotropic integrase mutants primarily defective for integration, not PIC nuclear import.	KPNA4 KPNA5 KPNA3	5.98e-06	9	146	3	12368302
Pubmed	Transportin 3 and importin α are required for effective nuclear import of HIV-1 integrase in virus-infected cells.	KPNA4 KPNA5 KPNA3	5.98e-06	9	146	3	21326825
Pubmed	Cellular distribution and karyophilic properties of matrix, integrase, and Vpr proteins from the human and simian immunodeficiency viruses.	KPNA4 KPNA5 KPNA3	5.98e-06	9	146	3	11035935
Pubmed	HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway.	KPNA4 KPNA5 KPNA3	5.98e-06	9	146	3	9275210
Pubmed	The karyophilic properties of human immunodeficiency virus type 1 integrase are not required for nuclear import of proviral DNA.	KPNA4 KPNA5 KPNA3	5.98e-06	9	146	3	10888652
Pubmed	Perlecan maintains microvessel integrity in vivo and modulates their formation in vitro.	HSPG2 PDGFRB CSPG4	5.98e-06	9	146	3	23320101
Pubmed	Active nuclear import of human immunodeficiency virus type 1 preintegration complexes.	KPNA4 KPNA5 KPNA3	5.98e-06	9	146	3	1631159
Pubmed	A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells.	KPNA4 KPNA5 KPNA3	5.98e-06	9	146	3	8105392
Pubmed	Characterization of the nuclear import pathway for HIV-1 integrase.	KPNA4 KPNA5 KPNA3	5.98e-06	9	146	3	11278458
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	ZFAT KALRN DNAH7 DST AARS2 XIRP2 NPC1L1 NUB1	6.85e-06	233	146	8	37704626
Pubmed	HIV-1 p17 and IFN-gamma both induce fructose 1,6-bisphosphatase.	KPNA4 KPNA5 KPNA3	8.51e-06	10	146	3	9282826
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	HEXB HSPG2 PDGFRB USP9X INTS1 LAMB2 RNF213 SCAMP2 ACSF2 PTK7 MAGI2 RSBN1 GTF2A1 UBA7 AKAP9 AARS2 CSPG4 NAXD ALDH18A1	1.13e-05	1451	146	19	30550785
Pubmed	The HIV-1 passage from cytoplasm to nucleus: the process involving a complex exchange between the components of HIV-1 and cellular machinery to access nucleus and successful integration.	KPNA4 KPNA5 KPNA3	1.17e-05	11	146	3	22509482
Pubmed	HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr.	KPNA4 KPNA5 KPNA3	1.17e-05	11	146	3	9562972
Pubmed	The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2.	PDGFRB CSPG4 CDH5	1.17e-05	11	146	3	22975327
Pubmed	Pericytes are progenitors for coronary artery smooth muscle.	PDGFRB CDH5 NOTCH3	1.17e-05	11	146	3	26479710
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	DNAJC13 IMPDH2 PDGFRB SPTBN1 INTS1 LAMB2 PEX12 SCAMP2 PTK7 RSBN1 GTF2A1 GTF2H4 AP2A1 CSPG4 ABCB8 PARL STX16	1.30e-05	1203	146	17	29180619
Pubmed	Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr.	KPNA4 KPNA5 KPNA3	1.55e-05	12	146	3	7494303
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	RALGAPA1 DNAJC13 IMPDH2 HSPA4L POLR2B SPTBN1 SPTBN2 NVL KIAA1549 MPDZ SCAMP2 PTK7 GTF2A1 URB1 AKAP9 CLPB PARL TMEM131 DIAPH3	1.59e-05	1487	146	19	33957083
Pubmed	Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity.	SREBF2 NPC1L1	1.75e-05	2	146	2	31417158
Pubmed	Changes in pericytic expression of NG2 and PDGFRB and vascular permeability in the sensory circumventricular organs of adult mouse by osmotic stimulation.	PDGFRB CSPG4	1.75e-05	2	146	2	23629811
Pubmed	CBR1 and CBR3 pharmacogenetics and their influence on doxorubicin disposition in Asian breast cancer patients.	CBR1 CBR3	1.75e-05	2	146	2	19016765
Pubmed	Anthracycline-related cardiomyopathy after childhood cancer: role of polymorphisms in carbonyl reductase genes--a report from the Children's Oncology Group.	CBR1 CBR3	1.75e-05	2	146	2	22124095
Pubmed	Cloning and expression of carbonyl reductase from rat testis.	CBR1 CBR3	1.75e-05	2	146	2	7705364
Pubmed	A chromosome 21 critical region does not cause specific Down syndrome phenotypes.	FAM3B CBR1	1.75e-05	2	146	2	15499018
Pubmed	The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein.	PKD1 PKHD1	1.75e-05	2	146	2	11919560
Pubmed	Cell surface chondroitin sulphate proteoglycan 4 (CSPG4) binds to the basement membrane heparan sulphate proteoglycan, perlecan, and is involved in cell adhesion.	HSPG2 CSPG4	1.75e-05	2	146	2	29462330
Pubmed	Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection.	KPNA4 KPNA3	1.75e-05	2	146	2	32320654
Pubmed	Structural basis for substrate specificity in human monomeric carbonyl reductases.	CBR1 CBR3	1.75e-05	2	146	2	19841672
Pubmed	Different functions between human monomeric carbonyl reductase 3 and carbonyl reductase 1.	CBR1 CBR3	1.75e-05	2	146	2	18493841
Pubmed	Endothelial nitric oxide synthase deficiency causes collateral vessel rarefaction and impairs activation of a cell cycle gene network during arteriogenesis.	CSPG4 NOS3	1.75e-05	2	146	2	20431061
Pubmed	Caspase-3/7-mediated Cleavage of β2-spectrin is Required for Acetaminophen-induced Liver Damage.	SPTBN1 SPTBN2	1.75e-05	2	146	2	26884715
Pubmed	Genotype of human carbonyl reductase CBR3 correlates with doxorubicin disposition and toxicity.	CBR1 CBR3	1.75e-05	2	146	2	18551042
Pubmed	Studies on reduction of S-nitrosoglutathione by human carbonyl reductases 1 and 3.	CBR1 CBR3	1.75e-05	2	146	2	21256830
Pubmed	Genetic loss of importin α4 causes abnormal sperm morphology and impacts on male fertility in mouse.	KPNA4 KPNA3	1.75e-05	2	146	2	33058343
Pubmed	NOS3 895G>T and CBR3 730G>A Are Associated with Recurrence Risk in Non-Muscle-Invasive Bladder Cancer with Intravesical Instillations of THP.	CBR3 NOS3	1.75e-05	2	146	2	30125887
Pubmed	Pathogenicity analysis of novel variations in Chinese Han patients with polycystic kidney disease.	PKD1 PKHD1	1.75e-05	2	146	2	28578020
Pubmed	Decreased NPC1L1 expression in the liver from Chinese female gallstone patients.	SREBF2 NPC1L1	1.75e-05	2	146	2	20144195
Pubmed	A Distinctive Genomic and Immunohistochemical Profile for NOTCH3 and PDGFRB in Myofibroma With Diagnostic and Therapeutic Implications.	PDGFRB NOTCH3	1.75e-05	2	146	2	31566039
Pubmed	Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-κB.	KPNA4 KPNA3	1.75e-05	2	146	2	28179530
Pubmed	3D biomimetic platform reveals the first interactions of the embryo and the maternal blood vessels.	PDGFRB CDH5 NOTCH3	2.01e-05	13	146	3	34741805
Pubmed	alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.	SPTBN1 SPTBN2 SPTBN4	2.01e-05	13	146	3	18796539
Pubmed	Perivascular cells expressing annexin A5 define a novel mesenchymal stem cell-like population with the capacity to differentiate into multiple mesenchymal lineages.	PDGFRB CSPG4 CDH5	2.01e-05	13	146	3	15857912
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	RALGAPA1 USP9X KIAA1549 MPDZ PFDN2 DST AKAP9 AP2A1 TBC1D1 ALDH18A1	2.04e-05	446	146	10	24255178
Pubmed	The general transcription factors of RNA polymerase II.	POLR2B GTF2A1 GTF2H4 TAF6	2.19e-05	39	146	4	8946909
Pubmed	Three transitions in the RNA polymerase II transcription complex during initiation.	POLR2B GTF2A1 GTF2H4 TAF6	2.19e-05	39	146	4	9405375
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	HMBOX1 CLTCL1 KALRN ABCA13 USP9X NVL RNF213 AARS2 SLC41A3 HELZ2 NAV2	2.32e-05	552	146	11	10737800
Pubmed	ATP activates transcription initiation from promoters by RNA polymerase II in a reversible step prior to RNA synthesis.	POLR2B GTF2A1 GTF2H4 TAF6	2.42e-05	40	146	4	2449431
Interaction	LINC02694 interactions	PSMG3 FAT3 CLPB	6.89e-06	6	143	3	int:LINC02694
Interaction	LOC254896 interactions	RAD51D FAT4 FAT3 ADGRV1 CSPG4	1.30e-05	43	143	5	int:LOC254896
Interaction	C2CD4B interactions	FAT4 FAT3 MPDZ ADGRV1 ALDH18A1	1.46e-05	44	143	5	int:C2CD4B
Cytoband	7q36	ABCB8 NUB1 NOS3	8.54e-05	27	145	3	7q36
GeneFamily	EF-hand domain containing\|Spectrins	SPTBN1 SPTBN2 SPTBN4	4.69e-06	7	94	3	1113
GeneFamily	Cadherin related	FAT4 CDHR3 FAT3	8.78e-05	17	94	3	24
GeneFamily	Armadillo repeat containing\|Importins	KPNA4 KPNA5 KPNA3	1.05e-04	18	94	3	596
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	HSPG2 MXRA5 KALRN PDGFRB OBSCN PTK7	1.94e-04	161	94	6	593
GeneFamily	Non-canonical poly(A) polymerases	TUT4 TUT1	5.52e-04	7	94	2	1318
GeneFamily	Blood group antigens\|CD molecules\|Proteoglycans	HSPG2 CSPG4	5.52e-04	7	94	2	570
GeneFamily	ATP binding cassette subfamily B	ABCB8 ABCB11	1.43e-03	11	94	2	806
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	KPNA4 KPNA5 KPNA3	1.44e-03	43	94	3	409
GeneFamily	Ankyrin repeat domain containing	ANKS6 CLPB ASB11 NOTCH3 PPP1R12C AGAP2	1.65e-03	242	94	6	403
GeneFamily	Dyneins, axonemal	DNAH7 DNAH14	3.46e-03	17	94	2	536
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 KALRN ABCA13 FAT3 OBSCN GRID1 ADGRV1 SORCS1 XIRP2 PKHD1	5.24e-10	184	145	10	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 KALRN ABCA13 FAT3 OBSCN GRID1 ADGRV1 SORCS1 XIRP2 PKHD1	5.24e-10	184	145	10	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 KALRN ABCA13 FAT3 OBSCN GRID1 ADGRV1 SORCS1 XIRP2 PKHD1	5.24e-10	184	145	10	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	NS-moderate-d_07-13-Epithelial-Ionocyte\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	IMPA2 FAT3 LAMB2 CBR1 CBR3 DST CLCNKA TBC1D1	1.23e-07	177	145	8	99500aed584f793aaf308f8afbf5d1c6a9b4ee55
ToppCell	COPD-Stromal-Pericyte\|Stromal / Disease state, Lineage and Cell class	IMPA2 PDGFRB GRID1 TBC1D1 B3GNT2 CSPG4 ABCB11 NOTCH3	1.88e-07	187	145	8	406ecd1dabb3ed8d871aef159f7bd1e383434953
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	FAT4 TUT4 CTNNAL1 SPTBN1 MPDZ RNF213 DST CDH5	3.14e-07	200	145	8	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	COVID-19-Heart-VSMC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	KALRN PDGFRB GRID1 OR51E2 TBC1D1 CSPG4 NOTCH3	1.76e-06	175	145	7	1125f0d3a5b2388fa77a820dea0288e824d84a82
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2-Transitional_Club-AT2_L.0.4.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CCDC22 FAT3 LAMB2 BEND3 FCGBP TMEM131 GDPGP1	1.76e-06	175	145	7	dbd9dac129fb6ae5f55e7b96d04b37585458dc4a
ToppCell	CV-Severe-7\|Severe / Virus stimulation, Condition and Cluster	HMBOX1 DNAJC13 KALRN PTBP2 RNF213 URB1 DST	1.89e-06	177	145	7	82fdd6185b368f54f03de389427cbe3071d21a99
ToppCell	facs-Heart-RV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFRB GRID1 SIPA1 PTK7 CSPG4 NOTCH3 AGAP2	1.89e-06	177	145	7	7c3d46ebd7e8726be6871aa9763e281fc0ec6ac8
ToppCell	facs-Heart-RV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFRB GRID1 SIPA1 PTK7 CSPG4 NOTCH3 AGAP2	1.89e-06	177	145	7	e7b1f3092e6b8d0d580f82648035f5ad12be6961
ToppCell	NS-critical-LOC-Epithelial-Ionocyte\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FAT3 LAMB2 FAM3B CBR3 PTK7 DST CLCNKA	2.04e-06	179	145	7	65a96bee7bc28f5bfc20f0fd92bcc0ab2eb5e06c
ToppCell	COVID-19-Heart-EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	KALRN PDGFRB CSPG4 BTNL9 CDH5 NOTCH3 AGAP2	2.28e-06	182	145	7	e67f3234165199085c793915ebb1f9bbd845e933
ToppCell	facs-Heart-LA-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IMPA2 PDGFRB SORCS1 TBC1D1 CSPG4 NOTCH3 AGAP2	2.73e-06	187	145	7	a12f383b02b07af32cc53a154685df8dba8fbd3f
ToppCell	facs-Heart-LA-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IMPA2 PDGFRB SORCS1 TBC1D1 CSPG4 NOTCH3 AGAP2	2.73e-06	187	145	7	c40c152fa14e6afc9188549534b64ccbaded56b3
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ABCA13 ADGRV1 MAGI2 FCGBP CLCNKA PKHD1 DIAPH3	2.73e-06	187	145	7	c41a2c81dd2ceef303f39f699032aa7d6ea67cf0
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	IMPA2 PDGFRB OBSCN GRID1 BCAR1 CSPG4 NOTCH3	2.73e-06	187	145	7	a2bf958ea59c359a265bfa437d59315e1920cdd4
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCA13 ADGRV1 DNAH7 DNAH14 MAGI2 PKHD1 DIAPH3	2.82e-06	188	145	7	af740fa78542438fdff627ea1f74f4eee43316be
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ABCA13 FAT3 DNAH7 DNAH14 MAGI2 PKHD1 DIAPH3	2.92e-06	189	145	7	904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCell	COVID-19-Heart-EC_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	HSPG2 KALRN SPTBN1 ARHGAP31 BTNL9 CDH5 NOS3	2.92e-06	189	145	7	fe49852ba15f948b384d6b4c258927c70b741357
ToppCell	moderate-Lymphoid-NK\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	HSPG2 FAT4 SORCS1 DST CSPG4 SRPX CDH5	2.92e-06	189	145	7	22a19365782003c18ec8dddcdbfdaa82c4e330f6
ToppCell	COVID-19-lung-Vein_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	HMBOX1 HSPG2 FAT4 CTNNAL1 KALRN SRPX NOS3	3.03e-06	190	145	7	1caeaef78326734c1e31a0c4739190d5c5a77b9e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 KALRN SPTBN1 ARHGAP31 BTNL9 CDH5 NOS3	3.47e-06	194	145	7	f76808666fb875fc787751cbfd924d9be20a8192
ToppCell	Endothelial-endothelial_cell_of_vein\|World / Lineage, Cell type, age group and donor	HSPG2 CTNNAL1 KALRN SRPX BTNL9 CDH5 NOS3	3.47e-06	194	145	7	3cbd9622a68e89add90e589867d88c83c5a33476
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 KALRN SPTBN1 ARHGAP31 BTNL9 CDH5 NOS3	3.47e-06	194	145	7	f5706ab6bc803606c4640ddd606617e4e797ccc9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 KALRN SPTBN1 ARHGAP31 BTNL9 CDH5 NOS3	3.47e-06	194	145	7	a52c5906fce43c2f72cf7e463a3d15cde06431f6
ToppCell	ASK440-Endothelial-Endothelium\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	HSPG2 FAT4 CTNNAL1 SPTBN1 SRPX BTNL9 CDH5	3.59e-06	195	145	7	304f0dc91bb57e98b0ca31d6bfb3ff9364e4da56
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	FAT4 PDGFRB FAT3 SPTBN1 PTK7 DST CNTNAP2	3.59e-06	195	145	7	1cdf5f296029ae424d9dba42e86a6d111e4896e6
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 KALRN SPTBN1 ARHGAP31 BTNL9 CDH5 NOS3	3.72e-06	196	145	7	8ad8efb631164b46f0c082572270188e5ead20bf
ToppCell	ASK454-Endothelial\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	FAT4 CTNNAL1 MPDZ LAMB2 BTNL9 CDH5 NOS3	3.72e-06	196	145	7	14dd6956ef420b660be0baf52a66960e57d75d16
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 KALRN SPTBN1 ARHGAP31 BTNL9 CDH5 NOS3	3.72e-06	196	145	7	b8f89a50114932c08fc5daac4b549adfe9df8e66
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 KALRN SPTBN1 ARHGAP31 BTNL9 CDH5 NOS3	3.72e-06	196	145	7	9606ea7e42f707e69ea891b3521037613b9675f5
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 KALRN SPTBN1 ARHGAP31 BTNL9 CDH5 NOS3	3.72e-06	196	145	7	145fcf73deba9638b391a1af6c39fa205dc9829f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 KALRN SPTBN1 ARHGAP31 BTNL9 CDH5 NOS3	3.72e-06	196	145	7	d0ff1082898d2db47c88d2678466514e9e9193d3
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 KALRN SPTBN1 ARHGAP31 BTNL9 CDH5 NOS3	3.84e-06	197	145	7	cd509e49bbdbf991cc5913960ff3ef275ad40628
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 KALRN SPTBN1 ARHGAP31 BTNL9 CDH5 NOS3	3.84e-06	197	145	7	0f467ef58f0c4dcc00b34b7b9639e03fb3ebe780
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 KALRN SPTBN1 ARHGAP31 BTNL9 CDH5 NOS3	3.84e-06	197	145	7	412cb5f37df57121ddd1492021445479c7cbccbf
ToppCell	LPS_only-Endothelial-Endothelial-FOXM1\|LPS_only / Treatment groups by lineage, cell group, cell type	KPNA5 HSPG2 MPDZ DHX57 NAV2 DIAPH3 POLQ	3.84e-06	197	145	7	038fd92750257d43d5e980fd06d77742b543f11a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 KALRN SPTBN1 ARHGAP31 BTNL9 CDH5 NOS3	3.97e-06	198	145	7	07701c73137947ed4a27e225975329235bbb8734
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 KALRN SPTBN1 ARHGAP31 BTNL9 CDH5 NOS3	3.97e-06	198	145	7	31ba87552be97c9b78c9e82f98e96699ccb19824
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 KALRN SPTBN1 ARHGAP31 BTNL9 CDH5 NOS3	3.97e-06	198	145	7	451003a21162eeae90739fdb502bb50b362d80c8
ToppCell	Tracheal-NucSeq-Endothelial-Endothelia_vascular-VE_systemic_venous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	HSPG2 KALRN CAPN11 ARHGAP31 BTNL9 CDH5 NOS3	3.97e-06	198	145	7	5c82dad416938d5c460069796d808170e7dbc8d9
ToppCell	Tracheal-NucSeq-Endothelial-Endothelia_vascular\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	HSPG2 KALRN CAPN11 ARHGAP31 BTNL9 CDH5 NOS3	3.97e-06	198	145	7	f7aa809040fa9f5782b92eec1f289d690eb5c7bd
ToppCell	Parenchymal-NucSeq-Stromal-Pericyte-Muscle_pericyte_systemic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CLTCL1 PDGFRB ADCK5 GRID1 CSPG4 STX16 NOTCH3	3.97e-06	198	145	7	882710bd6215e299257dd3df234292db9a2823ba
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 KALRN SPTBN1 ARHGAP31 BTNL9 CDH5 NOS3	3.97e-06	198	145	7	440af8f90c7afa1c07000806bcf9110b70f489fb
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 KALRN SPTBN1 ARHGAP31 BTNL9 CDH5 NOS3	3.97e-06	198	145	7	fa84bf8533d1b91d2c2bcf06b710670605072b89
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 KALRN SPTBN1 ARHGAP31 BTNL9 CDH5 NOS3	3.97e-06	198	145	7	0a172c6d997c7cfbad34b56e80121bd104dee67d
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors\|1_mon / Sample Type, Dataset, Time_group, and Cell type.	FAT4 USP9X KIAA1549 MPDZ OIP5 TMEM131 NOTCH3	4.11e-06	199	145	7	358c4b3037f59378db8916a2fbe9ed4830cf1449
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	HSPG2 FAT4 CTNNAL1 SRPX BTNL9 CDH5 NOS3	4.25e-06	200	145	7	ac6b8bc9998d303f788511b8f111e682ea9f3df8
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	HMBOX1 CTNNAL1 SPTBN1 RNF213 HELZ2 NUB1 CDH5	4.25e-06	200	145	7	edb64556b3fefe3144f73b6efe23b9ffd34091d2
ToppCell	Control_saline-Endothelial-Endothelial-Gen_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	FAT4 TUT4 CTNNAL1 SPTBN1 MPDZ DST CDH5	4.25e-06	200	145	7	3b97920e1e6e2f09ddba2a861baa9c00c2970f4c
ToppCell	Lung_Parenchyma-Control-Endothelial\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	HSPG2 KALRN SPTBN1 SRPX BTNL9 CDH5 NOS3	4.25e-06	200	145	7	41ac6adbf61763aa8a81a0ed586c4a5542a42cc5
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	HMBOX1 CTNNAL1 SPTBN1 RNF213 DST NUB1 CDH5	4.25e-06	200	145	7	79e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FAT4 TUT4 CTNNAL1 SPTBN1 DST CDH5 NOS3	4.25e-06	200	145	7	a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Mesenchymal-Mesoderm\|5w / Sample Type, Dataset, Time_group, and Cell type.	ADCK5 PEX12 GRID1 SIPA1 MAGI2 SSH3 HELZ2	4.25e-06	200	145	7	0927061536a664b4f7feb9e5b0a8c11ca0d5955c
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	HSPG2 KALRN SPTBN1 SRPX BTNL9 CDH5 NOS3	4.25e-06	200	145	7	5109b417c066ecca0252008206b4f4b7a14c8702
ToppCell	Parenchyma_Control_(B.)-Endothelial-TX\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	HSPG2 KALRN SPTBN1 SRPX BTNL9 CDH5 NOS3	4.25e-06	200	145	7	9e5627e11288713aa9b622aae40e849dd6eacd29
ToppCell	NS-critical-d_16-33-Myeloid-Monocyte-derived_Macrophage\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DNAJC13 TDRD7 CLPB CNTNAP2 HELZ2 NUB1	1.10e-05	153	145	6	859de35b24c5d7d73be1c213b90b43362ee2e0eb
ToppCell	NS-critical-d_16-33-Epithelial-Ionocyte\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FAT3 FAM3B CBR3 DST CLCNKA ASB11	1.88e-05	168	145	6	6a233045638cb83dab64789b996b7598c325001e
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HSPG2 IMPA2 PDGFRB FAT3 CSPG4 NOTCH3	2.01e-05	170	145	6	5570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCell	PND28-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CTNNAL1 NVL BCAR1 ACSF2 CCDC62 BTNL9	2.21e-05	173	145	6	03b50b2376d353748a32bf14a9fc8341ea61dbca
ToppCell	Adult-Mesenchymal-pericyte_cell-D175\|Adult / Lineage, Cell type, age group and donor	PDGFRB OBSCN GRID1 CSPG4 NOTCH3 PPP1R12C	2.21e-05	173	145	6	fd6653d6be9ca6ac36798590694efe03cb758c67
ToppCell	PND28-Endothelial-Endothelial_lymphatic\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CTNNAL1 NVL BCAR1 ACSF2 CCDC62 BTNL9	2.21e-05	173	145	6	2978c744d3c8dcaa2b9bb225abf846f82e8f9176
ToppCell	PND28-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CTNNAL1 NVL BCAR1 ACSF2 CCDC62 BTNL9	2.21e-05	173	145	6	12da47b90aecedaa31764ff7ddb853ee39123e9d
ToppCell	PND28-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CTNNAL1 NVL BCAR1 ACSF2 CCDC62 BTNL9	2.21e-05	173	145	6	23d4a315a0ad5c6fc77bcfc18b6c1ff55be99e8f
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_E\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	KALRN OIP5 CBR3 URB1 ARHGAP31 B3GNT2	2.21e-05	173	145	6	090dc3c5bd2652a65c2490fc889da858c3af368f
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_E\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	KALRN OIP5 CBR3 URB1 ARHGAP31 B3GNT2	2.29e-05	174	145	6	a79ebb01a5849c314e02594a9c95009dbb03cb8c
ToppCell	Adult-Endothelial-endothelial_cell_of_vein-D231\|Adult / Lineage, Cell type, age group and donor	HSPG2 FAT4 CTNNAL1 SRPX CDH5 NOS3	2.29e-05	174	145	6	2dd647c4fdf99fd1f7b838efef01baf2cbc3446d
ToppCell	RSV-Healthy-1\|Healthy / Virus stimulation, Condition and Cluster	PDGFRB RNF213 UBA7 HELZ2 NUB1 AGAP2	2.36e-05	175	145	6	ff3a27f512a3a710ebc863b7b75cce8167d5440b
ToppCell	RSV-Healthy-1\|RSV / Virus stimulation, Condition and Cluster	PDGFRB RNF213 UBA7 HELZ2 NUB1 AGAP2	2.36e-05	175	145	6	ca52b99b03535a5b3a2751d6981708dc5b255b91
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN PDGFRB GRID1 TBC1D1 CSPG4 NOTCH3	2.36e-05	175	145	6	316f2ea930437bf1243b1c0f45e6bd864112c6f2
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN PDGFRB GRID1 TBC1D1 CSPG4 NOTCH3	2.36e-05	175	145	6	a9f08e1e4c2997dcdd3e5d92daac480da19100b8
ToppCell	CV-Severe-7\|CV / Virus stimulation, Condition and Cluster	HMBOX1 KALRN PTBP2 RNF213 URB1 DST	2.44e-05	176	145	6	3de0c7d77210049e5616db21eed1490a17a5ec2d
ToppCell	3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IMPA2 FAM3B CBR1 CBR3 CLCNKA TBC1D1	2.52e-05	177	145	6	6d89042bda8e244babb68929e84b25edcb545a77
ToppCell	5'-Adult-Distal_Rectal-Epithelial-goblet-Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HMBOX1 DNAJC13 IMPA2 DNAH14 PTK7 FCGBP	2.52e-05	177	145	6	e1e45956887371b1c18f1eb479dd930031497520
ToppCell	3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IMPA2 FAM3B CBR1 CBR3 CLCNKA TBC1D1	2.52e-05	177	145	6	daaccf1249dcf816df4caca695a944f53078291a
ToppCell	3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IMPA2 FAM3B CBR1 CBR3 CLCNKA TBC1D1	2.52e-05	177	145	6	338bdda26796bf4e16072878c070212d1006cf57
ToppCell	3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IMPA2 FAM3B CBR1 CBR3 CLCNKA TBC1D1	2.52e-05	177	145	6	c5a16f984c836dbf7d0faf061677844167ab612a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 FAT4 ARHGAP31 BTNL9 CDH5 NOS3	2.60e-05	178	145	6	5f779a66aa42d1d8e8af17b4a08d5dcc733efd4c
ToppCell	COVID-19-kidney-vSMC/Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDGFRB GRID1 OR51E2 TBC1D1 CSPG4 NOTCH3	2.68e-05	179	145	6	111b1084f73306bdeffaaf240e7dbb4f5bf33de1
ToppCell	facs-Heart-RV-24m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 SPTBN1 ARHGAP31 BTNL9 CDH5 NOS3	2.68e-05	179	145	6	6aa211670e5d6e013d0980967aa0a4f8f2905efe
ToppCell	facs-Heart-RV-24m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 SPTBN1 ARHGAP31 BTNL9 CDH5 NOS3	2.68e-05	179	145	6	cf4d3828a3ce97932c68d06f5c65a070fc6d832c
ToppCell	COVID-19-Heart-VSMC\|Heart / Disease (COVID-19 only), tissue and cell type	PDGFRB GRID1 OR51E2 TBC1D1 CSPG4 NOTCH3	2.68e-05	179	145	6	a69ad6912b5c10bb9f9d800f724c792341e9bab1
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 KALRN SPTBN1 ARHGAP31 BTNL9 CDH5	2.68e-05	179	145	6	8f9e538c822940785130297712b75131812a4603
ToppCell	facs-Heart-RV-24m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 SPTBN1 ARHGAP31 BTNL9 CDH5 NOS3	2.68e-05	179	145	6	f9bc76ff25f88ee44c72499a0df9dc16f519c4cb
ToppCell	NS-moderate-d_16-33-Epithelial-Ionocyte\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	IMPA2 FAT3 LAMB2 CBR3 DST CLCNKA	2.77e-05	180	145	6	8af8b4af2dc72223ac71fc027e0d4280c5dd81f8
ToppCell	NS-critical-d_0-4-Epithelial-Ionocyte\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	IMPA2 LAMB2 CBR1 CBR3 DST CLCNKA	2.85e-05	181	145	6	cfc3ed541d93158ce26641ea30b7573d93600a11
ToppCell	5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IMPA2 CBR1 CBR3 DST CLCNKA TBC1D1	2.85e-05	181	145	6	40df0afcb6848202da54670e84f22d7c3a515d01
ToppCell	5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IMPA2 CBR1 CBR3 DST CLCNKA TBC1D1	2.85e-05	181	145	6	2b53a65ca5616a7b9f64232c3e0b7212d1e2f063
ToppCell	5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IMPA2 CBR1 CBR3 DST CLCNKA TBC1D1	2.85e-05	181	145	6	6aef84616e8d2faf54b7e9e6cd02f33c3066dabc
ToppCell	5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IMPA2 CBR1 CBR3 DST CLCNKA TBC1D1	2.85e-05	181	145	6	40d3829ae4aaf81e8616c3499ff8933137fc1cc4
ToppCell	NS-critical-d_07-13-Epithelial-Ionocyte\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	IMPA2 FAT3 LAMB2 CBR3 DST CLCNKA	3.04e-05	183	145	6	ba43bca2b45be1008eebd3f033cecb061fb3a966
ToppCell	critical-Epithelial-Ionocyte\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	IMPA2 FAT3 LAMB2 CBR3 DST CLCNKA	3.13e-05	184	145	6	58d36577eff814d46d72f031f3533d71549e3d6e
ToppCell	COVID-19-Endothelial_cells-Arterial_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	HSPG2 CTNNAL1 SRPX BTNL9 CDH5 NOS3	3.13e-05	184	145	6	0f19494789f38ab1a420545e15e748ca7eb345c3
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCA13 DNAH7 DNAH14 MAGI2 PKHD1 DIAPH3	3.33e-05	186	145	6	f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell	facs-SCAT-Fat-24m-Endothelial-endothelial_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN1 BCAR1 ARHGAP31 BTNL9 CDH5 NOS3	3.43e-05	187	145	6	43e35ec995afd8780893de42ac4ee466794991d7
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	KALRN PDGFRB OBSCN GRID1 CSPG4 NOTCH3	3.43e-05	187	145	6	86250acf088ec0c4800a0dfa031b0d4f7e52c342
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 KALRN SPTBN1 ARHGAP31 CDH5 NOS3	3.43e-05	187	145	6	35c382c0aabd46906113e5db30ea24bb8e658899
ToppCell	COVID-19-Endothelial_cells-Pulmonary_venous_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	HSPG2 CTNNAL1 KALRN SRPX CDH5 NOS3	3.43e-05	187	145	6	2d20193a6cacdfa4877457c97b0077408942186c
ToppCell	facs-SCAT-Fat-24m-Endothelial\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN1 BCAR1 ARHGAP31 BTNL9 CDH5 NOS3	3.43e-05	187	145	6	8ca9481d661626f6f0e1b61eb142b051192a9208
Drug	HYCRON linker	KPNA4 KPNA5 KPNA3	2.40e-06	5	143	3	CID011069636
Drug	CNI-H0294	KPNA4 KPNA5 KPNA3	2.40e-06	5	143	3	CID000073088
Drug	AC1LA3FM	KPNA4 KPNA5 KPNA3	4.79e-06	6	143	3	CID000480797
Disease	spinocerebellar ataxia type 5 (implicated_via_orthology)	SPTBN1 SPTBN2 SPTBN4	4.44e-07	4	143	3	DOID:0050882 (implicated_via_orthology)
Disease	infantile myofibromatosis (is_implicated_in)	PDGFRB NOTCH3	2.33e-05	2	143	2	DOID:0080109 (is_implicated_in)
Disease	Myofibromatosis	PDGFRB NOTCH3	2.33e-05	2	143	2	C0206648
Disease	Infantile myofibromatosis	PDGFRB NOTCH3	2.33e-05	2	143	2	cv:C0432284
Disease	Myofibromatosis	PDGFRB NOTCH3	2.33e-05	2	143	2	cv:C0206648
Disease	Infantile myofibromatosis	PDGFRB NOTCH3	2.33e-05	2	143	2	C0432284
Disease	Malignant neoplasm of breast	KPNA5 KALRN STRBP OBSCN SREBF2 LDHAL6B SIX4 BCAR1 SORCS1 GTF2A1 AKAP9 ABCB8 CDH5 NOS3 NOTCH3 AGAP2	6.85e-05	1074	143	16	C0006142
Disease	Cystic kidney	FAT4 ANKS6	3.45e-04	6	143	2	C0022679
Disease	proteinuria (implicated_via_orthology)	ANKS6 LAMB2 SORCS1	4.11e-04	30	143	3	DOID:576 (implicated_via_orthology)
Disease	Polycystic kidney disease, type 2	ANKS6 PKD1	4.82e-04	7	143	2	C2751306
Disease	peripheral neuropathy	IMPA2 XIRP2	4.82e-04	7	143	2	EFO_0003100
Disease	trans fatty acid measurement, trans-16:1n-7 fatty acid measurement	OLFM4 DIAPH3	6.41e-04	8	143	2	EFO_0006821, EFO_0006822
Disease	Polycystic Kidney, Type 1 Autosomal Dominant Disease	ANKS6 PKD1	6.41e-04	8	143	2	C0887850
Disease	Colorectal Carcinoma	KALRN ABCA13 SPTBN2 OBSCN GRID1 AKAP9 DUSP21 CCDC62 PKHD1 ABCB11 CDH5	6.47e-04	702	143	11	C0009402
Disease	Polycystic Kidney, Autosomal Dominant	ANKS6 PKD1	8.21e-04	9	143	2	C0085413
Disease	opioid dependence	FAT4 SPTBN2 ADGRV1 BCAR1 ABCB8 DIAPH3	1.08e-03	237	143	6	EFO_0005611
Disease	childhood gender nonconformity	SPTBN2 GRID1 NAV2	1.19e-03	43	143	3	EFO_0020103
Disease	Cystic Kidney Diseases	FAT4 ANKS6	1.25e-03	11	143	2	C1691228
Disease	Schizophrenia	IMPA2 PDGFRB ABCA13 SPTBN2 SREBF2 GRID1 ITGAM MAGI2 GPR153 B3GNT2 CNTNAP2 KPNA3	1.27e-03	883	143	12	C0036341
Disease	coronary artery disease (is_implicated_in)	KALRN ARHGAP31 PARL NOS3	1.45e-03	100	143	4	DOID:3393 (is_implicated_in)
Disease	hyperglycemia (is_marker_for)	HSPG2 ITGAM	1.76e-03	13	143	2	DOID:4195 (is_marker_for)
Disease	polycystic kidney disease (implicated_via_orthology)	ANKS6 PKD1	2.04e-03	14	143	2	DOID:0080322 (implicated_via_orthology)
Disease	acute graft vs. host disease, donor genotype effect measurement	KALRN TMEM131	2.35e-03	15	143	2	EFO_0004599, EFO_0007892
Disease	vascular endothelial growth factor measurement	PTGR3 PTK7 CAPN11	2.56e-03	56	143	3	EFO_0004762
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	PKD1 PKHD1	2.68e-03	16	143	2	DOID:0110861 (implicated_via_orthology)
Disease	urate measurement, spine bone mineral density	FAM3B TOX4 NAV2	2.83e-03	58	143	3	EFO_0004531, EFO_0007701
Disease	PR interval	HSPG2 KALRN SPTBN1 OBSCN LAMB2 MAGI2 NAV2 ALDH18A1	2.93e-03	495	143	8	EFO_0004462
Disease	Muscle hypotonia	RALGAPA1 INTS1	3.02e-03	17	143	2	C0026827
Disease	colorectal health	ZFAT ADGRV1 DDX11 MAGI2 DIAPH3	3.03e-03	201	143	5	EFO_0008460
Disease	cortical thickness	HSPG2 PTBP2 STRBP FAT3 SPTBN1 SPTBN2 BEND3 ADGRV1 PKD1 PKHD1 NAV2 TMEM131 DIAPH3	3.04e-03	1113	143	13	EFO_0004840
Disease	Insulin Resistance	SREBF2 ITGAM NOS3	3.12e-03	60	143	3	C0021655
Disease	Insulin Sensitivity	SREBF2 ITGAM NOS3	3.12e-03	60	143	3	C0920563
Disease	Hereditary Diffuse Gastric Cancer	FAT4 HIKESHI SREBF2 FCGBP NAXD NOS3	3.13e-03	293	143	6	C1708349
Disease	Stomach Neoplasms	FAT4 HIKESHI SREBF2 FCGBP NAXD NOS3	3.34e-03	297	143	6	C0038356
Disease	Malignant neoplasm of stomach	FAT4 HIKESHI SREBF2 FCGBP NAXD NOS3	3.51e-03	300	143	6	C0024623
Disease	Tinnitus	SPTBN1 CNTNAP2 PKHD1 TMEM131	3.75e-03	130	143	4	HP_0000360
Disease	lifestyle measurement, anxiety disorder measurement	ACSF2 SORCS1 URB1 APOL5	4.52e-03	137	143	4	EFO_0007795, EFO_0010724

Protein segments in the cluster

Peptide	Gene	Start	Entry
VVRAGALSNVSVSIQ	BTNL9	216	Q6UXG8
VAAALVSQIQLEAVQ	AKAP9	2551	Q99996
VLQAQVDSLAAVVLQ	nan	441	Q9N2K0
VLQAQVDSLAAVVLQ	nan	441	Q9N2J8
VLALARGVNASAVVN	CSPG4	2026	Q6UVK1
RGVNASAVVNVTVRA	CSPG4	2031	Q6UVK1
TLVELSAQVGQLQAR	CCDC62	141	Q6P9F0
EALARLQQGVSATVA	BCAR1	461	P56945
NAVIRIIGGNSQFTI	FAT4	2396	Q6V0I7
VRVNILANDNVAGIV	ADGRV1	2691	Q8WXG9
RVAAQVDGGAQVQQV	AP2A1	811	O95782
ATVQGVQLLRAQVAA	ABCA13	4196	Q86UQ4
VGQITNEALSNIRTV	ABCB11	936	O95342
AVAIQAIRNAKGNSI	AGAP2	931	Q99490
LRNINTVRAINVALG	ADCK5	481	Q3MIX3
QLATAQAGIILVSVN	ACSF2	141	Q96CM8
AQGVNVNLVTINRVS	ASB11	86	Q8WXH4
VVENSAQRVIHLAGQ	CCDC22	406	O60826
ARQQGAQLQTIGFVL	CAPN11	456	Q9UMQ6
IVEGLRHNSVQLQVA	DIAPH3	326	Q9NSV4
AAQVGVSIQAVVAIL	CDH5	591	P33151
ITAGNRAQIQAVIDA	KPNA5	366	O15131
VLQELRGTVAQQVTG	RAD51D	181	O75771
AGTAQARIQVVVLSA	HSPG2	2031	P98160
NNVAATARVLVIGAT	NVL	396	O15381
QGNIDQVAVVAINVL	MFSD8	261	Q8NHS3
RRATVAAGNSVVQVV	KIAA1549	1211	Q9HCM3
AAGNSVVQVVNVSRL	KIAA1549	1216	Q9HCM3
ALRVFRGNVQLAAQT	NUB1	511	Q9Y5A7
VREIVQQSLSVGNFA	BEND3	726	Q5T5X7
SSNQVINVGLILIAA	OVOS1	1021	Q6IE37
QEVKVQTAALRAVGN	KPNA3	296	O00505
VGDRILAVNGQSIIN	MAGI2	971	Q86UL8
IFVGTRENISNAQAL	FXR2	346	P51116
QQALGQELARVVQGS	INTS1	1381	Q8N201
AVQAVRALATGQFAV	TRMU	356	O75648
VAAATGVQSQVQLVQ	IGHV1-69	11	P01742
TRNRQLEGISVVAQQ	DST	5491	Q03001
NLQVIGGNVVTAAQA	IMPDH2	296	P12268
VQQQIAAAARRLALA	CCDC120	121	Q96HB5
LANRRISQAVVAQVT	HMBOX1	181	Q6NT76
VSAEQVIAGFNRLRQ	PFDN2	21	Q9UHV9
ANSNLVIITAGARQE	LDHAL6B	136	Q9BYZ2
NNTVTAQIGIVAVVR	OR51E2	136	Q9H255
AVALGGNTVILQAVR	OR51I2	36	Q9H344
TAIALFQTLAVQVGR	GPR153	191	Q6NV75
GVSNAARDFINVILQ	KALRN	2906	O60229
TADAQGVFQILIRNR	NOTCH3	1881	Q9UM47
VLRLSQALGNVTVVQ	NAXD	231	Q8IW45
REATQRIQAVLAVQG	LMLN2	96	A0A1B0GTW7
TVQAALEEAQRAQGI	LAMB2	1606	P55268
AVGFVAQLNVERGVQ	GDPGP1	91	Q6ZNW5
ATRQAAGIRLQDQVV	DDX11	376	Q96FC9
QLGNVARGINIAIVN	FAM3B	101	P58499
VAAATGVQSQVQLVQ	IGHV1-69D	11	A0A0B4J2H0
QAAVQLALRAGQIIR	IMPA2	21	O14732
ASIVEQVSVLQNQGR	ALDH18A1	96	P54886
VQNAQQRGVFGRVLT	NOS3	1061	P29474
TRRLVVQQAGQAVAG	OBSCN	1496	Q5VST9
AVGCTRRLVVQQAGQ	OBSCN	1676	Q5VST9
FINVTRVAQLGAGQL	NPC1L1	136	Q9UHC9
VAGRLVQTAAQQVAE	HIKESHI	6	Q53FT3
GVRQQAVQLNIFTAV	HEATR5B	816	Q9P2D3
FLQRNTIIAAVSGVA	C2orf92	186	A0A1B0GVN3
QAIQRVGQAVNLAVG	CTNNAL1	66	Q9UBT7
LVTVAGQVVSLAQGQ	FCGBP	4911	Q9Y6R7
NQLTGTIQVAQRIDR	CDHR3	286	Q6ZTQ4
GQVNVQLQRGEFVVS	DHX57	1311	Q6P158
RQAINTIVQGSAADI	POLQ	2466	O75417
SVVAQQILTIQRGIN	DNAH7	1391	Q8WXX0
QILTIQRGINAGADI	DNAH7	1396	Q8WXX0
TNITKVAIVNAVGNR	FAT3	1996	Q8TDW7
ARQQNLTIGLTIFAV	A3GALT2	96	U3KPV4
DVNAQNRLGASVLTV	ANKS6	136	Q68DC2
ARAAGQRLATQAVVL	CCDC78	201	A2IDD5
TARDVTRGQAAVQQL	CBR1	36	P16152
TRGQAAVQQLQAEGL	CBR1	41	P16152
AGQVQQLALEVVNIV	DNAJC13	1786	O75165
RIGIFNVVVESSLQQ	DNAH14	736	Q0VDD8
TARDVARGQAAVQQL	CBR3	36	O75828
VINISSLVGAIGQAQ	HSD17B14	136	Q9BPX1
FVLNRIQAVRAQSAA	GRID1	581	Q9ULK0
INRNNSVVQVLLAAG	CLPB	176	Q9H078
QAIRNGVNRNSAIIG	CNTNAP2	1251	Q9UHC6
VLTRAQSQLVVVGDA	HELZ2	901	Q9BYK8
TQVALVVQVAEAARA	HEXB	31	P07686
NRITAIVNASVEVVN	DUSP21	46	Q9H596
VSVNAVQTVVRQGEN	PDGFRB	216	P09619
LAVVVQDQLGAAVVA	PKD1	2551	P98161
AVVLALGAALVNVQI	ABCB8	151	Q9NUT2
QRTVTGIIAANVLVF	PARL	166	Q9H300
LGAVVFSRVTNNVVL	OIP5	101	O43482
IVQLVARALGSAAQV	GRIN3B	296	O60391
AQVGAVRVVRAVAAQ	RSBN1	51	Q5VWQ0
TFISEGVRVNVVQNN	TAF6	261	P49848
GVRVNVVQNNLALLI	TAF6	266	P49848
FINGSALNVQIIAAL	USP9X	241	Q93008
VVRFLVEQGATVNQA	PPP1R12C	116	Q9BZL4
TLNQRAQAVLQAVTA	PTBP2	141	Q9UKA9
QVRQASQVGVAVLGT	PIGQ	51	Q9BRB3
TDGVLLAQIIQVVAN	NAV2	116	Q8IVL1
QARAGVSQVLNRLTF	POLR2B	461	P30876
VILNGLNVGNTQAVA	SIX4	376	Q9UIU6
GQAVGEVVARLQLVS	SIPA1	666	Q96FS4
AVVSAAQAGLLRQQE	SCAMP2	76	O15127
QVQATVVGLLAAVAA	SLC41A3	151	Q96GZ6
QVGQLAAAGINVAVV	CCT8L1P	281	A6NM43
QVGQLAAAGINVAVV	CCT8L2	281	Q96SF2
VNTAVSAAVQAVRGR	STRBP	596	Q96SI9
IIRNNVIIQVSGAEG	PKHD1	2296	P08F94
LQNLAHRVITAQQTG	PKHD1	3686	P08F94
VQAVNVGQLLAVNAE	TDRD7	511	Q8NHU6
QSVVQLQGSRVVVGA	ITGAM	36	P11215
NVNVGVRTAAALLDQ	SRPX	321	P78539
AGVQLGRLTVQDIQA	PEX12	196	O00623
GNIARVNLTTNTIAV	OLFM4	346	Q6UX06
ILEILQNAAQVARSA	URB1	1831	O60287
TRLLAVTGEQAQQAR	AARS2	776	Q5JTZ9
QASRVAVVNQIARQL	SPTBN1	901	Q01082
QSVVTLQGSAVVANR	SSH3	601	Q8TE77
AGNQTVVRVFLLGQT	B3GNT2	171	Q9NY97
STGVKRIVQALNANV	AAGAB	156	Q6PD74
LGAAAAITNIVTNVL	APOL5	176	Q9BWW9
LLVGISAQQNRVVGA	CLTCL1	166	P53675
VGIVQRAQLVQALQA	CLCNKA	591	P51800
VQQAIASGITAQQII	GTF2H4	351	Q92759
VLQLVGVQHVNFTNR	PRXL2C	206	Q7RTV5
LTNSGQLLQVVRAAN	GTF2A1	156	P52655
FQIIRGISAQEIQTG	XIRP2	861	A4UGR9
LATAINQRGIYVIQA	RNF213	1536	Q63HN8
VQGTQAAVAALQDLR	ZFAT	1101	Q9P243
TEQNIRAGTQAVLQV	RALGAPA1	516	Q6GYQ0
RAGTQAVLQVFIINS	RALGAPA1	521	Q6GYQ0
NQQAVEVLRHTGQTV	MPDZ	441	O75970
AQAVAINARLREVQT	SPTBN2	1031	O15020
AQLNRAVQVVVHTGD	UBA7	96	P41226
RAIGNAAKSQIVTNV	HSPA4L	46	O95757
QKGRVAIAVAINQAI	UROC1	516	Q96N76
VAANVTSRVAGRLQN	TUT1	551	Q9H6E5
RLLGNVVASLAQALQ	STX16	156	O14662
VRLAGAQAIFEAQQL	TBC1D10C	366	Q8IV04
AQAIFEAQQLAGVRR	TBC1D10C	371	Q8IV04
VQAQRVLTQTANGTL	SREBF2	206	Q12772
LARVVGNVENTLFIN	TMEM131	176	Q92545
LQVANGRIQSLEATI	TBC1D1	1101	Q86TI0
QVAVQAAEGLLRQGN	SPTBN4	1256	Q9H254
QLLQTTRIGVAVNGV	TCEA3	41	O75764
GDAAFLAVRVQQVVI	ARHGAP31	191	Q2M1Z3
LVRNRFVGVNASDIN	PTGR3	66	Q8N4Q0
VTSAVGALLQNRVLV	ZC2HC1B	176	Q5TFG8
GALLQNRVLVATNEV	ZC2HC1B	181	Q5TFG8
LTDLRAVNAVNAVIQ	ERVK-19	86	Q9WJR5
NVGIFRVTVQVDNSL	SORCS1	861	Q8WY21
RNSSVAAAQLVRNLV	TUT4	1381	Q5TAX3
LAGQRRQDVNITVAT	PTK7	396	Q13308
AQIVTRSVLQAAAAA	TOX4	416	O94842
VSQEAGNRAVLLAVA	PSMG3	86	Q9BT73
VNRLSVLGAITSVQQ	ETF1	66	P62495
QEVKVQTAALRAVGN	KPNA4	296	O00629
NLVGSARRTVQLNVQ	MXRA5	2126	Q9NR99