Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	flippase activity	ATP8A2 ATP10B ATP10D	5.20e-05	17	87	3	GO:0140327
GeneOntologyMolecularFunction	glycosylceramide flippase activity	ATP10B ATP10D	5.61e-05	3	87	2	GO:0140351
GeneOntologyMolecularFunction	ATPase-coupled intramembrane lipid transporter activity	ATP8A2 ATP10B ATP10D	2.42e-04	28	87	3	GO:0140326
GeneOntologyCellularComponent	phospholipid-translocating ATPase complex	ATP8A2 ATP10B ATP10D	2.62e-05	14	89	3	GO:1990531
Domain	HIF-1a_CTAD	HIF1A EPAS1	2.14e-05	2	87	2	PF08778
Domain	HIF-1_TAD_C	HIF1A EPAS1	2.14e-05	2	87	2	IPR014887
Domain	P_typ_ATPase_c	ATP8A2 ATP10B ATP10D	3.42e-05	14	87	3	IPR032630
Domain	P-type_ATPase_N	ATP8A2 ATP10B ATP10D	3.42e-05	14	87	3	IPR032631
Domain	P-type_ATPase_IV	ATP8A2 ATP10B ATP10D	3.42e-05	14	87	3	IPR006539
Domain	PhoLip_ATPase_C	ATP8A2 ATP10B ATP10D	3.42e-05	14	87	3	PF16212
Domain	PhoLip_ATPase_N	ATP8A2 ATP10B ATP10D	3.42e-05	14	87	3	PF16209
Domain	HIF_alpha_subunit	HIF1A EPAS1	6.42e-05	3	87	2	IPR021537
Domain	HIF-1	HIF1A EPAS1	6.42e-05	3	87	2	PF11413
Domain	-	CTDSPL2 ATP8A2 ATP10B ATP10D	2.25e-04	64	87	4	3.40.50.1000
Domain	-	ATP8A2 ATP10B ATP10D	4.39e-04	32	87	3	3.40.1110.10
Domain	-	ATP8A2 ATP10B ATP10D	4.39e-04	32	87	3	2.70.150.10
Domain	HAD-like_dom	CTDSPL2 ATP8A2 ATP10B ATP10D	5.06e-04	79	87	4	IPR023214
Domain	ATPase_P-typ_cyto_domN	ATP8A2 ATP10B ATP10D	5.74e-04	35	87	3	IPR023299
Domain	DNA/RNA_helicase_DEAH_CS	BLM BRIP1 ERCC6L2	5.74e-04	35	87	3	IPR002464
Domain	ATPase_P-typ_P_site	ATP8A2 ATP10B ATP10D	6.24e-04	36	87	3	IPR018303
Domain	P_typ_ATPase	ATP8A2 ATP10B ATP10D	6.24e-04	36	87	3	IPR001757
Domain	ATPASE_E1_E2	ATP8A2 ATP10B ATP10D	6.24e-04	36	87	3	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP8A2 ATP10B ATP10D	6.76e-04	37	87	3	IPR008250
Domain	E1-E2_ATPase	ATP8A2 ATP10B ATP10D	6.76e-04	37	87	3	PF00122
Domain	EF-hand_1	RCVRN MACF1 ACTN1 CALML6 RYR3	7.22e-04	152	87	5	PF00036
Domain	DEAH_ATP_HELICASE	BLM BRIP1 ERCC6L2	7.32e-04	38	87	3	PS00690
Domain	Hydrolase_3	ATP10B ATP10D	9.42e-04	10	87	2	PF08282
Domain	-	DTNA RCVRN MACF1 ACTN1 CALML6 RYR3	1.38e-03	261	87	6	1.10.238.10
Domain	Ldl_recept_b	LRP8 SORL1	1.88e-03	14	87	2	PF00058
Domain	LDLRB	LRP8 SORL1	1.88e-03	14	87	2	PS51120
Domain	LY	LRP8 SORL1	2.17e-03	15	87	2	SM00135
Domain	LDLR_classB_rpt	LRP8 SORL1	2.17e-03	15	87	2	IPR000033
Domain	EF-hand-dom_pair	DTNA RCVRN MACF1 ACTN1 CALML6 RYR3	2.23e-03	287	87	6	IPR011992
Domain	Disintegrin_CS	ADAM19 ADAM2	2.47e-03	16	87	2	IPR018358
Domain	ADAM_CR	ADAM19 ADAM2	3.13e-03	18	87	2	PF08516
Domain	SH3	SH3PXD2A MACF1 STAM NEB ASAP1	3.39e-03	216	87	5	PS50002
Domain	SH3_domain	SH3PXD2A MACF1 STAM NEB ASAP1	3.66e-03	220	87	5	IPR001452
Domain	-	ADAM19 ADAM2	3.86e-03	20	87	2	4.10.70.10
Domain	Disintegrin	ADAM19 ADAM2	4.25e-03	21	87	2	PF00200
Domain	DISIN	ADAM19 ADAM2	4.25e-03	21	87	2	SM00050
Domain	Ank	TANC2 SLF1 KANK4 TEX14 ASAP1	4.26e-03	228	87	5	PF00023
Domain	EF_HAND_2	RCVRN MACF1 ACTN1 CALML6 RYR3	4.50e-03	231	87	5	PS50222
Domain	EF_hand_dom	RCVRN MACF1 ACTN1 CALML6 RYR3	4.58e-03	232	87	5	IPR002048
Pubmed	Osteoclasts adapt to physioxia perturbation through DNA demethylation.	TET2 HIF1A TNFRSF11A EPAS1	1.39e-09	7	89	4	34661337
Pubmed	Hepatocyte-specific HIF-1α ablation improves obesity-induced glucose intolerance by reducing first-pass GLP-1 degradation.	HIF1A GCG EPAS1	1.62e-08	3	89	3	31281892
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	SEMA4D HIF1A SF3B1 PSMA5 MACF1 HUWE1 PRPF8 PHIP ASAP1 LRP8	2.91e-08	358	89	10	32460013
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TET2 SEMA4D ADAM19 SF3B1 CRIM1 ZNF655 ZNF521 MACF1 ZNF350 ACTN1 STAM HUWE1 PRPF8 INTS8 CBS RYR3	1.53e-07	1285	89	16	35914814
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	TANC2 FOXO1 TET2 MCMBP PTPN14 HIVEP1 MAP7D3 SH3PXD2A NCOA7 MACF1 ERBIN PLK4	2.03e-06	861	89	12	36931259
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	BLM FOXO1 MCMBP PTPN14 HIVEP1 DTNA MACF1 HUWE1 ZCCHC2 SORL1	2.72e-06	588	89	10	38580884
Pubmed	Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension.	HIF1A EPAS1	6.48e-06	2	89	2	31515405
Pubmed	Epigenetic regulation of HIF-1α in renal cancer cells involves HIF-1α/2α binding to a reverse hypoxia-response element.	HIF1A EPAS1	6.48e-06	2	89	2	21841824
Pubmed	A microfluidic oxygen gradient demonstrates differential activation of the hypoxia-regulated transcription factors HIF-1α and HIF-2α.	HIF1A EPAS1	6.48e-06	2	89	2	28840922
Pubmed	ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement.	HIF1A EPAS1	6.48e-06	2	89	2	23437279
Pubmed	Does SF3B1/TET2 Double Mutation Portend Better or Worse Prognosis Than Isolated SF3B1 or TET2 Mutation?	TET2 SF3B1	6.48e-06	2	89	2	30587503
Pubmed	Neuronal HIF-1α and HIF-2α deficiency improves neuronal survival and sensorimotor function in the early acute phase after ischemic stroke.	HIF1A EPAS1	6.48e-06	2	89	2	26746864
Pubmed	HIF-1α and HIF-2α correlate with migration and invasion in gastric cancer.	HIF1A EPAS1	6.48e-06	2	89	2	20559021
Pubmed	Loss of either hypoxia inducible factor 1 or 2 promotes lung cancer cell colonization.	HIF1A EPAS1	6.48e-06	2	89	2	21610325
Pubmed	Effect of radiation and ibuprofen on normoxic renal carcinoma cells overexpressing hypoxia-inducible factors by loss of von Hippel-Lindau tumor suppressor gene function.	HIF1A EPAS1	6.48e-06	2	89	2	15217953
Pubmed	Constitutive expression of HIF-α plays a major role in generation of clear-cell phenotype in human primary and metastatic renal carcinoma.	HIF1A EPAS1	6.48e-06	2	89	2	25046225
Pubmed	Hypoxia induced HIF-1/HIF-2 activity alters trophoblast transcriptional regulation and promotes invasion.	HIF1A EPAS1	6.48e-06	2	89	2	26531845
Pubmed	Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma.	HIF1A EPAS1	6.48e-06	2	89	2	20032376
Pubmed	The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability.	HIF1A EPAS1	6.48e-06	2	89	2	36482296
Pubmed	Loss of apolipoprotein E receptor LR11 in Alzheimer disease.	LRP8 SORL1	6.48e-06	2	89	2	15313836
Pubmed	Low oxygen atmosphere facilitates proliferation and maintains undifferentiated state of umbilical cord mesenchymal stem cells in an hypoxia inducible factor-dependent manner.	HIF1A EPAS1	6.48e-06	2	89	2	24726658
Pubmed	Increasing expression of hypoxia-inducible proteins in the Barrett's metaplasia-dysplasia-adenocarcinoma sequence.	HIF1A EPAS1	6.48e-06	2	89	2	17437013
Pubmed	DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumor immunotolerance.	HIF1A EPAS1	6.48e-06	2	89	2	32718321
Pubmed	Hypoxia inducible factor: a potential prognostic biomarker in oral squamous cell carcinoma.	HIF1A EPAS1	6.48e-06	2	89	2	26880584
Pubmed	Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.	HIF1A EPAS1	6.48e-06	2	89	2	15964822
Pubmed	Localization of immunoreactive HIF-1alpha and HIF-2alpha in neuroendocrine cells of both benign and malignant prostate glands.	HIF1A EPAS1	6.48e-06	2	89	2	17562539
Pubmed	Hypoxia Drives Centrosome Amplification in Cancer Cells via HIF1α-dependent Induction of Polo-Like Kinase 4.	HIF1A PLK4	6.48e-06	2	89	2	34933912
Pubmed	Assignment of the human nebulin gene (NEB) to chromosome band 2q24.2 and the alpha 1 (III) collagen gene (COL3A1) to chromosome band 2q32.2 by in situ hybridization; the FRA2G common fragile site lies between the two genes in the 2q31 band.	COL3A1 NEB	6.48e-06	2	89	2	9284930
Pubmed	[Expression of HIF-1alpha mRNA and HIF-2alpha mRNA in placentas of pregnant women with intrahepatic cholestasis of pregnancy].	HIF1A EPAS1	6.48e-06	2	89	2	17718430
Pubmed	Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2.	HIF1A EPAS1	6.48e-06	2	89	2	24363272
Pubmed	The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha.	HIF1A EPAS1	6.48e-06	2	89	2	17804822
Pubmed	Hypoxia and the expression of HIF-1alpha and HIF-2alpha in the retina of streptozotocin-injected mice and rats.	HIF1A EPAS1	6.48e-06	2	89	2	20005221
Pubmed	Inherent DNA-binding specificities of the HIF-1α and HIF-2α transcription factors in chromatin.	HIF1A EPAS1	6.48e-06	2	89	2	30429208
Pubmed	HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism.	HIF1A EPAS1	6.48e-06	2	89	2	29176561
Pubmed	Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex.	HIF1A EPAS1	6.48e-06	2	89	2	12123724
Pubmed	Hnf-1β transcription factor is an early hif-1α-independent marker of epithelial hypoxia and controls renal repair.	HNF1B HIF1A	6.48e-06	2	89	2	23704921
Pubmed	Endothelial HIF-2α as a Key Endogenous Mediator Preventing Emphysema.	HIF1A EPAS1	6.48e-06	2	89	2	32515984
Pubmed	Increased size of solid organs in patients with Chuvash polycythemia and in mice with altered expression of HIF-1alpha and HIF-2alpha.	HIF1A EPAS1	6.48e-06	2	89	2	20140661
Pubmed	HIF-1-mediated expression of Foxo1 serves an important role in the proliferation and apoptosis of osteoblasts derived from children's iliac cancellous bone.	FOXO1 HIF1A	6.48e-06	2	89	2	29512721
Pubmed	Upregulated hypoxia inducible factor-1alpha and -2alpha pathway in rheumatoid arthritis and osteoarthritis.	HIF1A EPAS1	6.48e-06	2	89	2	12823854
Pubmed	The acquired radioresistance in HeLa cells under conditions mimicking hypoxia was attenuated by a decreased expression of HIF subunit genes induced by RNA interference.	HIF1A EPAS1	6.48e-06	2	89	2	25805230
Pubmed	Roles of hypoxia-inducible factor-1alpha (HIF-1alpha) versus HIF-2alpha in the survival of hepatocellular tumor spheroids.	HIF1A EPAS1	6.48e-06	2	89	2	20513003
Pubmed	Differential regulation of HIF-mediated pathways increases mitochondrial metabolism and ATP production in hypoxic osteoclasts.	HIF1A EPAS1	6.48e-06	2	89	2	23303559
Pubmed	Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis.	HIF1A EPAS1	6.48e-06	2	89	2	19439736
Pubmed	HIF-1α and HIF-2α induced angiogenesis in gastrointestinal vascular malformation and reversed by thalidomide.	HIF1A EPAS1	6.48e-06	2	89	2	27249651
Pubmed	Differential Contribution of N- and C-Terminal Regions of HIF1α and HIF2α to Their Target Gene Selectivity.	HIF1A EPAS1	6.48e-06	2	89	2	33321829
Pubmed	Differential expression of hypoxia-inducible factors related to the invasiveness of epithelial ovarian cancer.	HIF1A EPAS1	6.48e-06	2	89	2	34824343
Pubmed	Mutational analysis of the BRCA1-interacting genes ZNF350/ZBRK1 and BRIP1/BACH1 among BRCA1 and BRCA2-negative probands from breast-ovarian cancer families and among early-onset breast cancer cases and reference individuals.	BRIP1 ZNF350	6.48e-06	2	89	2	12872252
Pubmed	Hypoxia Inducible Factors Modify Collagen I Fibers in MDA-MB-231 Triple Negative Breast Cancer Xenografts.	HIF1A EPAS1	6.48e-06	2	89	2	29247885
Pubmed	Oxygen-dependent changes in binding partners and post-translational modifications regulate the abundance and activity of HIF-1α/2α.	HIF1A EPAS1	6.48e-06	2	89	2	34285132
Pubmed	The hypoxia-inducible factors HIF1α and HIF2α are dispensable for embryonic muscle development but essential for postnatal muscle regeneration.	HIF1A EPAS1	6.48e-06	2	89	2	28232488
Pubmed	Hypoxia inducible factor promotes murine allergic airway inflammation and is increased in asthma and rhinitis.	HIF1A EPAS1	6.48e-06	2	89	2	21517900
Pubmed	The Kaposi's Sarcoma-Associated Herpesvirus ORF34 Protein Interacts and Stabilizes HIF-2α via Binding to the HIF-2α bHLH and PAS Domains.	HIF1A EPAS1	6.48e-06	2	89	2	31189709
Pubmed	Neural regulation of hypoxia-inducible factors and redox state drives the pathogenesis of hypertension in a rodent model of sleep apnea.	HIF1A EPAS1	6.48e-06	2	89	2	25953833
Pubmed	HIF1α is necessary for exercise-induced neuroprotection while HIF2α is needed for dopaminergic neuron survival in the substantia nigra pars compacta.	HIF1A EPAS1	6.48e-06	2	89	2	25796140
Pubmed	Impact of HIF-1alpha and HIF-2alpha on proliferation and migration of human pulmonary artery fibroblasts in hypoxia.	HIF1A EPAS1	6.48e-06	2	89	2	16263938
Pubmed	The relation between hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression with anemia and outcome in surgically treated head and neck cancer.	HIF1A EPAS1	6.48e-06	2	89	2	16826581
Pubmed	Cancer stem cells and hypoxia-inducible factors (Review).	HIF1A EPAS1	6.48e-06	2	89	2	29845228
Pubmed	2-Methoxyestradiol synergizes with sorafenib to suppress hepatocellular carcinoma by simultaneously dysregulating hypoxia-inducible factor-1 and -2.	HIF1A EPAS1	6.48e-06	2	89	2	25218350
Pubmed	Distinct roles for the hypoxia-inducible transcription factors HIF-1α and HIF-2α in human osteoclast formation and function.	HIF1A EPAS1	6.48e-06	2	89	2	33273561
Pubmed	Hypoxia-inducible factor pathway activation in restless legs syndrome patients.	HIF1A EPAS1	6.48e-06	2	89	2	21985026
Pubmed	Clinicopathological and prognostic significance of HIF-1α and HIF-2α expression in small cell lung cancer.	HIF1A EPAS1	6.48e-06	2	89	2	23375698
Pubmed	Epidermal deletion of HIF-2α stimulates wound closure.	HIF1A EPAS1	6.48e-06	2	89	2	24037341
Pubmed	Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells.	HIF1A EPAS1	6.48e-06	2	89	2	16611993
Pubmed	Primary endothelial cell-specific regulation of hypoxia-inducible factor (HIF)-1 and HIF-2 and their target gene expression profiles during hypoxia.	HIF1A EPAS1	6.48e-06	2	89	2	30917010
Pubmed	Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation.	HIF1A EPAS1	6.48e-06	2	89	2	14645546
Pubmed	5-formylcytosine and 5-hydroxymethyluracil as surrogate markers of TET2 and SF3B1 mutations in myelodysplastic syndrome, respectively.	TET2 SF3B1	6.48e-06	2	89	2	31488558
Pubmed	Targeting hypoxia-inducible factors with 32-134D safely and effectively treats diabetic eye disease in mice.	HIF1A EPAS1	6.48e-06	2	89	2	37227777
Pubmed	Hypoxia-inducible factors 1alpha and 2alpha exert both distinct and overlapping functions in long bone development.	HIF1A EPAS1	6.48e-06	2	89	2	19899108
Pubmed	Hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha are expressed in kaposi sarcoma and modulated by insulin-like growth factor-I.	HIF1A EPAS1	6.48e-06	2	89	2	16899596
Pubmed	HIF-1α and HIF-2α redundantly promote retinal neovascularization in patients with ischemic retinal disease.	HIF1A EPAS1	6.48e-06	2	89	2	34128478
Pubmed	Prognostic value and clinicopathological differences of HIFs in colorectal cancer: evidence from meta-analysis.	HIF1A EPAS1	6.48e-06	2	89	2	24324596
Pubmed	HIF-mediated hypoxic response is missing in severely hypoxic uterine leiomyomas.	HIF1A EPAS1	6.48e-06	2	89	2	20204822
Pubmed	The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes.	HIF1A EPAS1	6.48e-06	2	89	2	16971531
Pubmed	Altered Behavioral Performance in the Neuron-Specific HIF-1- and HIF-2-Deficient Mice Following Chronic Hypoxic Exposure.	HIF1A EPAS1	6.48e-06	2	89	2	33966229
Pubmed	The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation.	HIF1A EPAS1	6.48e-06	2	89	2	38363679
Pubmed	Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia.	HIF1A EPAS1	6.48e-06	2	89	2	19454749
Pubmed	Correlation of HIF-1α/HIF-2α expression with FDG uptake in lung adenocarcinoma.	HIF1A EPAS1	6.48e-06	2	89	2	27663442
Pubmed	Expression of HIF-1α and HIF-2α correlates to biological and clinical significance in papillary thyroid carcinoma.	HIF1A EPAS1	6.48e-06	2	89	2	26846782
Pubmed	Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice.	HIF1A EPAS1	6.48e-06	2	89	2	26422241
Pubmed	Hypoxia inducible factor 1α and hypoxia inducible factor 2α play distinct and functionally overlapping roles in oral squamous cell carcinoma.	HIF1A EPAS1	6.48e-06	2	89	2	20807755
Pubmed	Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma.	HIF1A EPAS1	6.48e-06	2	89	2	12209691
Pubmed	Expression of hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha with progression of keratinocytic neoplasms.	HIF1A EPAS1	6.48e-06	2	89	2	19660915
Pubmed	Myeloid HIFs are dispensable for resolution of inflammation during skeletal muscle regeneration.	HIF1A EPAS1	6.48e-06	2	89	2	25750431
Pubmed	Up-regulation of hypoxia-inducible factor 1 alpha and hemodynamic responses following massive small bowel resection.	HIF1A EPAS1	6.48e-06	2	89	2	23845627
Pubmed	The accumulations of HIF-1α and HIF-2α by JNK and ERK are involved in biphasic effects induced by different levels of arsenite in human bronchial epithelial cells.	HIF1A EPAS1	6.48e-06	2	89	2	23194660
Pubmed	Hypoxia-inducible factor activity promotes antitumor effector function and tissue residency by CD8+ T cells.	HIF1A EPAS1	6.48e-06	2	89	2	33792560
Pubmed	HIF-1α and HIF-2α: siblings in promoting angiogenesis of residual hepatocellular carcinoma after high-intensity focused ultrasound ablation.	HIF1A EPAS1	6.48e-06	2	89	2	24551189
Pubmed	Role of hypoxia inducible factor-1α in the regulation of the cancer-specific variant of organic anion transporting polypeptide 1B3 (OATP1B3), in colon and pancreatic cancer.	HIF1A SLCO1B3	6.48e-06	2	89	2	23924606
Pubmed	Opposite prognostic roles of HIF1α and HIF2α expressions in bone metastatic clear cell renal cell cancer.	HIF1A EPAS1	6.48e-06	2	89	2	27244898
Pubmed	Hypoxia Inducible Factor (HIF) transcription factor family expansion, diversification, divergence and selection in eukaryotes.	HIF1A EPAS1	6.48e-06	2	89	2	28614393
Pubmed	HIF-1α protein is upregulated in HIF-2α depleted cells via enhanced translation.	HIF1A EPAS1	6.48e-06	2	89	2	22673574
Pubmed	Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype.	HIF1A EPAS1	6.48e-06	2	89	2	17097563
Pubmed	HIF-2α not HIF-1α overexpression confers poor prognosis in non-small cell lung cancer.	HIF1A EPAS1	6.48e-06	2	89	2	28653893
Pubmed	HIF1A and EPAS1 mRNA and protein expression during in vitro culture of human primary term cytotrophoblasts and effect of oxygen tension on their expression.	HIF1A EPAS1	6.48e-06	2	89	2	27692362
Pubmed	Differential regulation of pulmonary vascular cell growth by hypoxia-inducible transcription factor-1α and hypoxia-inducible transcription factor-2α.	HIF1A EPAS1	6.48e-06	2	89	2	23492195
Pubmed	Hypoxia-inducible factors and the response to hypoxic stress.	HIF1A EPAS1	6.48e-06	2	89	2	20965423
Pubmed	Expression of hypoxia inducible factor-1α and 2α in conventional renal cell carcinoma with or without sarcomatoid differentiation.	HIF1A EPAS1	6.48e-06	2	89	2	19914104
Pubmed	Expression of hypoxia-inducible factor-1α and -2α in whole-mount prostate histology: relation with dynamic contrast-enhanced MRI and Gleason score.	HIF1A EPAS1	6.48e-06	2	89	2	23588703
Pubmed	Impaired expression of HIF-2α induces compensatory expression of HIF-1α for the recovery from anemia.	HIF1A EPAS1	6.48e-06	2	89	2	25557133
Interaction	SFN interactions	TANC2 FOXO1 TET2 HIF1A PTPN14 MAP7D3 SH3PXD2A MACF1 ACTN1 TEX14 NEB PRPF8 ERBIN PLK4	1.71e-06	692	88	14	int:SFN
GeneFamily	ATPase phospholipid transporting	ATP8A2 ATP10B ATP10D	1.78e-05	15	63	3	1210
Coexpression	GSE11057_EFF_MEM_VS_CENT_MEM_CD4_TCELL_DN	CCNE1 LGMN HIVEP1 MACF1 ACTN1 CBS PHIP ASAP1	2.47e-07	189	88	8	M3112
Coexpression	AIZARANI_LIVER_C9_LSECS_1	LGMN HIF1A MAP7D3 CRIM1 NCOA7 MACF1 ACTN1 EPAS1 ASAP1	8.64e-07	304	88	9	M39113
Coexpression	GSE21670_TGFB_VS_IL6_TREATED_STAT3_KO_CD4_TCELL_DN	C5orf34 SH3PXD2A ACTN1 RALGAPA2 ATP10D ASAP1 SORL1	5.10e-06	200	88	7	M7432
Coexpression	AIZARANI_LIVER_C20_LSECS_3	LGMN HIF1A CRIM1 NCOA7 MACF1 ACTN1 EPAS1 ASAP1	6.90e-06	295	88	8	M39121
Coexpression	LAKE_ADULT_KIDNEY_C2_PODOCYTES	TET2 PTPN14 CRIM1 MACF1 ZNF804A ERBIN RYR3	7.48e-06	212	88	7	M39221
Coexpression	AIZARANI_LIVER_C29_MVECS_2	COL3A1 HIF1A PTPN14 CRIM1 NCOA7 ACTN1 EPAS1 ASAP1	1.06e-05	313	88	8	M39128
Coexpression	GEORGES_TARGETS_OF_MIR192_AND_MIR215	BLM CCNE1 LGMN SEMA4D HNF1B C5orf34 BRIP1 SLF1 MACF1 STAM PLK4 LRP8	4.28e-05	892	88	12	M18120
Coexpression	GSE46606_UNSTIM_VS_CD40L_IL2_IL5_DAY1_STIMULATED_BCELL_UP	SPATA7 SH3PXD2A TNFRSF11A STAM MGME1 SORL1	5.43e-05	197	88	6	M9862
Coexpression	GSE16450_IMMATURE_VS_MATURE_NEURON_CELL_LINE_6H_IFNA_STIM_UP	AFF2 SLCO1B3 IL17RD ATP10D ASAP1 SORL1	5.74e-05	199	88	6	M7414
Coexpression	GSE339_CD4POS_VS_CD8POS_DC_IN_CULTURE_UP	SEMA4D HIF1A SF3B1 TNFRSF11A STAM RYR3	5.90e-05	200	88	6	M5119
Coexpression	GSE16450_IMMATURE_VS_MATURE_NEURON_CELL_LINE_12H_IFNA_STIM_UP	LGMN C5orf34 CRIM1 ATP10D ASAP1 SORL1	5.90e-05	200	88	6	M7430
Coexpression	ANDERSEN_CHOLANGIOCARCINOMA_CLASS1	HNF1B MLH3 PTPN14 PAQR5	6.07e-05	63	88	4	M282
Coexpression	RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN	COL3A1 FOXO1 LGMN DTNA ERCC6L2 ZFHX3 TNFRSF11A RALGAPA2 ANGPTL1 LRP8 SORL1	8.15e-05	807	88	11	M16651
Coexpression	HE_LIM_SUN_FETAL_LUNG_C1_EARLY_STALK_CELL	BLM C5orf34 BRIP1 SLF1 GLCE PAQR5 IL17RD CBS PLK4	1.22e-04	567	88	9	M45692
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	FOXO1 SEMA4D MCMBP ADAM19 SF3B1 SLF1 MAP7D3 ZNF655 MACF1 HUWE1 PRPF8 ERBIN PHIP ASAP1 SORL1	1.24e-04	1492	88	15	M40023
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	BLM HIF1A HIVEP1 MAN2A1 CRIM1 MACF1 ZFHX3 STAM PHF8 ZNF804A PHIP	1.37e-04	856	88	11	M4500
CoexpressionAtlas	DevelopingKidney_e15.5_anlage of loop of Henle_emap-31283_top-relative-expression-ranked_500	HNF1B PTPN14 SLC12A1 CTDSPL2 ERCC6L2 PAQR5 NCOA7 HUWE1 ASAP1 SORL1	5.20e-06	402	86	10	gudmap_developingKidney_e15.5_anlage of loop of Henle_500
CoexpressionAtlas	DevelopingKidney_e15.5_Proximal Tubules_emap-28005_top-relative-expression-ranked_1000	SPATA7 TET2 SEMA4D HNF1B SLC12A1 CTDSPL2 ERCC6L2 PAQR5 NCOA7 HUWE1 ATP10D RYR3 SORL1	1.09e-05	758	86	13	gudmap_developingKidney_e15.5_Proximal Tubules_1000
CoexpressionAtlas	DevelopingKidney_e14.5 whole kidney - wildtype_emap-6674_k-means-cluster#5_top-relative-expression-ranked_500	HNF1B C5orf34 CRIM1 IL17RD PLK4	6.81e-05	105	86	5	gudmap_developingKidney_e14.5 whole kidney - wildtype_500_k5
CoexpressionAtlas	DevelopingKidney_e15.5_anlage of loop of Henle_emap-31283_top-relative-expression-ranked_1000	HNF1B PTPN14 SLC12A1 CTDSPL2 ERCC6L2 KANK4 PAQR5 NCOA7 HUWE1 INTS8 ASAP1 SORL1	8.39e-05	795	86	12	gudmap_developingKidney_e15.5_anlage of loop of Henle_1000
ToppCell	LPS_only-Endothelial-Endothelial-Vein\|LPS_only / Treatment groups by lineage, cell group, cell type	FOXO1 HIF1A ZNF521 NCOA7 ACTN1 RALGAPA2 EPAS1	1.45e-07	200	88	7	b036f5e22c95a3b14391785b6e91aa183b9bc9a8
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 TANC2 TGM4 LGMN SH3PXD2A TNFRSF11A	7.84e-07	160	88	6	0544bc465af208da448858d6e174ff56f2e08a46
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TANC2 CDH26 SH3PXD2A MACF1 ATP10B SORL1	1.51e-06	179	88	6	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	FOXO1 ADAM19 HIVEP1 DTNA MACF1 ACTN1	1.77e-06	184	88	6	d2bf0135eb56bb410997dccea39c5ede88a0617f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BLM COL3A1 C5orf34 BRIP1 ACTN1 PLK4	1.94e-06	187	88	6	e41e39fd3791acf8ae5376cc5061e196d96868ae
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BLM COL3A1 C5orf34 BRIP1 ACTN1 PLK4	1.94e-06	187	88	6	cefa211ef224e803ea9467882e2ca74d0b1492f1
ToppCell	droplet-Heart-4Chambers-18m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4D PTPN14 CRIM1 ATP8A2 GCG ADAM2	2.13e-06	190	88	6	6f71a9f74af7cd9a674753cfc9833ebe5bba0fa2
ToppCell	droplet-Heart-nan-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4D CDH26 PTPN14 ATP8A2 ZNF521 RALGAPA2	2.55e-06	196	88	6	e386526332138e636aef2542c11316347a45689c
ToppCell	IPF-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	COL3A1 TANC2 SH3PXD2A DTNA ZNF521 MACF1	2.63e-06	197	88	6	f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCell	normal_Lung-Fibroblasts-COL13A1+_matrix_FBs\|Fibroblasts / Location, Cell class and cell subclass	LGMN MLH3 CRIM1 ATP8A2 KANK4 MACF1	2.70e-06	198	88	6	e0e47cf65774191981840b22905b2094b95abe0f
ToppCell	Control-Control-Lymphocyte-T/NK-CD4+_T_activated\|Control / Disease, condition lineage and cell class	FOXO1 SH3PXD2A MACF1 TEX14 ZCCHC2 SORL1	2.70e-06	198	88	6	ee71543559836fd59adc0da877b2ca538cba60cb
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Vein\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FOXO1 HIF1A ZNF521 ACTN1 RALGAPA2 EPAS1	2.78e-06	199	88	6	cfb624c7728046fc7f3ef071f57e4d7b013f3fef
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	HIF1A SLF1 ZNF521 NCOA7 RALGAPA2 EPAS1	2.86e-06	200	88	6	6f531a418ff25b59a543800cf4bce7b72404ce08
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FOXO1 CDH26 PTPN14 CRIM1 EPAS1	1.97e-05	166	88	5	7a45785a40b7425f97be67bab1c5ceb69b2bd85a
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FOXO1 CDH26 PTPN14 CRIM1 EPAS1	1.97e-05	166	88	5	bbd382812f8a84a5d99888de2d7cca3a8b5e4695
ToppCell	droplet-Lung-21m-Hematologic-myeloid-interstitial_macrophage-interstitial_macrophage_l12\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TANC2 LGMN USP51 ZFHX3 TNFRSF11A	2.09e-05	168	88	5	aaafa7243c44e6852d92e3445335fc4a1018f416
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BLM CCNE1 BRIP1 PLK4 LRP8	2.15e-05	169	88	5	0bc8ef341ce307b19018d4ac8de0a4d04254209d
ToppCell	droplet-Lung-nan-18m-Myeloid-Interstitial_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TANC2 LGMN ADAM19 ZFHX3 TNFRSF11A	2.27e-05	171	88	5	7ca404539344e14dcd90c746c9122f713a7db78b
ToppCell	droplet-Lung-nan-18m-Myeloid-lung_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TANC2 LGMN ADAM19 ZFHX3 TNFRSF11A	2.27e-05	171	88	5	ab113c8e773b0af47a87aed50e96be3ba71c3c82
ToppCell	3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BRIP1 AFF2 DTNA CARD14 LRP8	2.27e-05	171	88	5	b51bbeacb172e8b5de519ada85543d7ae9914b3c
ToppCell	3'_v3-blood-Mast\|blood / Manually curated celltypes from each tissue	AFF2 ZNF521 EPAS1 ATP10D RYR3	2.34e-05	172	88	5	e7a46bbeff749ca59b9f1357409ce1ad59dd22dd
ToppCell	droplet-Lung-nan-21m-Myeloid-Interstitial_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TANC2 LGMN USP51 ZFHX3 TNFRSF11A	2.40e-05	173	88	5	31ea04e65876c42b90245d280f0b6439bfffbace
ToppCell	droplet-Lung-nan-21m-Myeloid-lung_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TANC2 LGMN USP51 ZFHX3 TNFRSF11A	2.40e-05	173	88	5	1cff815536f620e32b9805666e1aa711462c2d25
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPN14 ZNF521 MACF1 TNFRSF11A ASAP1	2.75e-05	178	88	5	ad3de3e03a401dac64431a541899445262246347
ToppCell	3'_v3-bone_marrow-Mast\|bone_marrow / Manually curated celltypes from each tissue	AFF2 ZNF521 EPAS1 ATP10D RYR3	2.90e-05	180	88	5	b37ee81b792213d6595b4ec65d04bc35d83321c7
ToppCell	PBMC-Control-cDC_12\|Control / Compartment, Disease Groups and Clusters	BLM CCNE1 BRIP1 SLF1 LRP8	3.06e-05	182	88	5	4774066d0f9986abc3d13a2a3bc99ce4f1327ae0
ToppCell	hematopoetic_progenitors-CD34+_MEP_2\|World / Lineage and Cell class	AFF2 FAM81B PAQR5 ZNF521 ZNF804A	3.06e-05	182	88	5	a7e7aa10f14111a6c7ba22e0f1668dcaa124714d
ToppCell	droplet-Heart-4Chambers-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN14 CRIM1 ATP8A2 GCG ADAM2	3.14e-05	183	88	5	6c4a09c02e30e1f24dde39f8cb8c5b453826ee2e
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-5\|TCGA-Liver / Sample_Type by Project: Shred V9	BLM C5orf34 TNFRSF11A INTS8 PLK4	3.14e-05	183	88	5	f604a8b62c7088fad8365dbf8d910fc980bd3ba8
ToppCell	(00)_Basal-(4)_1wkpi\|(00)_Basal / shred by cell type and Timepoint	FOXO1 MAN2A1 CRIM1 ACTN1 EPAS1	3.31e-05	185	88	5	bf82ba905e5eee1c39a2731702071d3de10a78b8
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIF1A HIVEP1 SF3B1 HUWE1 ERBIN	3.31e-05	185	88	5	eb7d3c1363d5fedc611f9c1a91ea823de251355e
ToppCell	5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPN14 ADAM19 ZNF521 TNFRSF11A ASAP1	3.40e-05	186	88	5	40070d9cd20188ba49b32acfca9bc16256b38bf5
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPN14 CRIM1 ZNF521 MACF1 ASAP1	3.40e-05	186	88	5	20340a5b5cc7f07386498a4ef937d6fbc9e347c4
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 FOXO1 HNF1B HIF1A PTPN14	3.48e-05	187	88	5	c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	CRIM1 DTNA MACF1 ACTN1 RYR3	3.57e-05	188	88	5	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 PTPN14 SLC12A1 NEXMIF RYR3	3.66e-05	189	88	5	e059be2965cca70ff5576df055d0af1775b76e00
ToppCell	LA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	CRIM1 DTNA MACF1 ACTN1 RYR3	3.66e-05	189	88	5	6b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCell	RA-10._Endothelium_II\|World / Chamber and Cluster_Paper	CRIM1 ACTN1 RALGAPA2 EPAS1 ASAP1	3.66e-05	189	88	5	75c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM19 ZNF521 TNFRSF11A RALGAPA2 ASAP1	3.76e-05	190	88	5	876bd2eb9ed2624cb23bdcf6b989e4fa34d099e3
ToppCell	COVID-19-lung-Vein_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CRIM1 ZNF521 ACTN1 RALGAPA2 EPAS1	3.76e-05	190	88	5	1caeaef78326734c1e31a0c4739190d5c5a77b9e
ToppCell	Mesenchymal-airway_smooth_muscle_cell\|World / Lineage, Cell type, age group and donor	COL3A1 ADAM19 DTNA ACTN1 RYR3	3.76e-05	190	88	5	645e56b02edc3702c7db917b8ecd5eed0decaf71
ToppCell	Control-Endothelial-VE_Venous\|Endothelial / Disease state, Lineage and Cell class	FOXO1 CRIM1 NCOA7 ACTN1 EPAS1	3.76e-05	190	88	5	4e30155203b4a8c5e496fcbe9348b67b98ebc625
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM19 ZNF521 TNFRSF11A RALGAPA2 ASAP1	3.76e-05	190	88	5	be9f36127028f52ca5fc1b32ba15a6c26aad69ac
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM19 ZNF521 TNFRSF11A RALGAPA2 ASAP1	3.76e-05	190	88	5	09a8855901c3c9332dbaab3e40166485b696d0f1
ToppCell	COVID-19-kidney-Proliferating_T_cell\|COVID-19 / Disease (COVID-19 only), tissue and cell type	BLM CCNE1 BRIP1 SLF1 PLK4	3.85e-05	191	88	5	bae388e0e9447d576e68465d73d8313ef6925ffa
ToppCell	COVID-19-Heart-EC_(POSTN)\|Heart / Disease (COVID-19 only), tissue and cell type	CRIM1 PAQR5 ZNF521 ACTN1 RALGAPA2	3.95e-05	192	88	5	c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	HIF1A DTNA MACF1 ACTN1 ASAP1	3.95e-05	192	88	5	8b86db2ebe0199fee0e9800566a619a24bfdeed5
ToppCell	facs-Aorta-Heart-3m\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SF3B1 MACF1 ZFHX3 GCG ERBIN	3.95e-05	192	88	5	1ccc47792edf9ee23501c8e2165d11271636b66a
ToppCell	RV-10._Endothelium_II\|RV / Chamber and Cluster_Paper	CRIM1 ACTN1 RALGAPA2 EPAS1 ASAP1	4.05e-05	193	88	5	01c2df9206f1527c578e808978e58196c35e72f5
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 HNF1B PTPN14 SLC12A1 ACTN1	4.05e-05	193	88	5	263d185af6ed80e639f864e4966268e0862c61dc
ToppCell	5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLCO1B3 NCOA7 EPAS1 ASAP1 RYR3	4.05e-05	193	88	5	c0973a2c97deb7176c2f617c8760a55f7edc9839
ToppCell	droplet-Pancreas-Endocrine-21m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SF3B1 SH3PXD2A GCG DPP3 NEB	4.15e-05	194	88	5	3a3ecedcdc7691cf21775818b598208fcb980c29
ToppCell	(4)_Endothelial_cells-(42)_EC-sinusoidal\|(4)_Endothelial_cells / Cell class and subclass of bone marrow stroma cells in homeostatis	LGMN HIF1A ZNF521 ACTN1 RALGAPA2	4.15e-05	194	88	5	4199900d16623eca02d674d5ada7f0989e47955e
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	COL3A1 GLCE PAQR5 ZNF521 MACF1	4.15e-05	194	88	5	b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLF1 ZNF521 SLCO1B3 MACF1 EPAS1	4.15e-05	194	88	5	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3PXD2A GCG DPP3 HUWE1 NEB	4.15e-05	194	88	5	0b023de48ed8a550d169bbe954881eb04bf4f981
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLF1 CRIM1 ZNF521 SLCO1B3 EPAS1	4.25e-05	195	88	5	56efeb58df19f357d7d5ce87348d4f196a595421
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_COL-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	COL3A1 MAP7D3 CRIM1 SH3PXD2A ACTN1	4.25e-05	195	88	5	78cfde21dde4b877fc76c8b0d5ddaabe44b912d7
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	COL3A1 GLCE PAQR5 ZNF521 MACF1	4.25e-05	195	88	5	0e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCell	facs-Brain_Myeloid-Hippocampus\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 TANC2 MACF1 ZFHX3 GCG	4.25e-05	195	88	5	a1478021a3ed0e779716393124ca2a7770c433b7
ToppCell	CF-Myeloid\|CF / Disease state, Lineage and Cell class	HIF1A ACTN1 RALGAPA2 ASAP1 SORL1	4.25e-05	195	88	5	ecf604de496f389a49429d0bb211e1db6019cc8b
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPN14 CRIM1 ZNF521 ACTN1 EPAS1	4.25e-05	195	88	5	81a98ebb0d43f416f9a8bba580531dc0cfea8f74
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL3A1 ADAM19 DTNA ACTN1 ZNF804A	4.36e-05	196	88	5	1522958a92e0126326a9f0d9fb1c5b5c50b001ea
ToppCell	Fibroblasts-DKK3+_Fibroblasts\|Fibroblasts / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	COL3A1 PTPN14 ACTN1 IL17RD ANGPTL1	4.36e-05	196	88	5	24d64b67aa9b0e8215ad06f9101c1314b3483620
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland-Myoepithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	AFF2 DTNA ACTN1 IL17RD RYR3	4.36e-05	196	88	5	a58bdf9de05d13d84211e09a933679d485bf8ab4
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL3A1 ADAM19 DTNA ACTN1 ZNF804A	4.36e-05	196	88	5	1c8294014713684b50885e638668f2ce75f357f0
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 HIF1A SF3B1 ZNF655 ERBIN	4.36e-05	196	88	5	151f1a29a91f8b234e9b6ed062666357a2f69128
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland-Myoepithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DTNA KANK4 ZNF521 ACTN1 RYR3	4.46e-05	197	88	5	f0475ad9c09c6da418dba17d3d3c1aaa2ef9ab4e
ToppCell	facs-Trachea-3m\|Trachea / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL3A1 HIF1A SF3B1 GCG ERBIN	4.46e-05	197	88	5	e77016d64b1cac9825fec7cfe5071f1567401187
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CRIM1 ZFHX3 ACTN1 CALML6 EPAS1	4.46e-05	197	88	5	15a08b04acb1cb7e84aeb072c650ce07374181f5
ToppCell	facs-Trachea-nan-3m\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 HIF1A SF3B1 GCG ERBIN	4.46e-05	197	88	5	0353d925ee4b7aefc2c51b5fab873f465cdf9ebc
ToppCell	Monocytes-NUPR1+_Monocytes\|Monocytes / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	TANC2 LGMN PAQR5 ACTN1 TNFRSF11A	4.46e-05	197	88	5	8a058c9d9285acd7cf2fb8e34f7602a86b5d6c89
ToppCell	(04)_Interm._basal>secr.-(2)_GFP_FOXI1\|(04)_Interm._basal>secr. / shred by cell type by condition	TANC2 CRIM1 PSMA5 NCOA7 SORL1	4.68e-05	199	88	5	53ca3861f9e00dab3f3fbefb0837857ee39ab084
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar-Dividing_AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	BLM BRIP1 SLCO1B3 PLK4 MGME1	4.68e-05	199	88	5	1d5a3366474c17e3df0ba5cf11b586655529e9bd
ToppCell	Transverse-B_cell-B_cell_cycling\|B_cell / Region, Cell class and subclass	C5orf34 BRIP1 AFF2 ZNF804A PLK4	4.68e-05	199	88	5	170ae68963d31f3b821b6f0e8f0c039bea0bc981
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SLF1 ZNF521 MACF1 RALGAPA2 EPAS1	4.79e-05	200	88	5	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Vein\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	FOXO1 HIF1A ZNF521 ACTN1 RALGAPA2	4.79e-05	200	88	5	7eb366b2c5394af7c77650bde6261e7dac67154e
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	HIF1A SLF1 MACF1 RALGAPA2 EPAS1	4.79e-05	200	88	5	edb64556b3fefe3144f73b6efe23b9ffd34091d2
ToppCell	Influenza-Influenza_Severe-Myeloid-cDC\|Influenza_Severe / Disease, condition lineage and cell class	BRIP1 MRPS25 ZNF521 TNFRSF11A RYR3	4.79e-05	200	88	5	b8415a68ad6f4fea562236a1b0da0dc376d874fb
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TET2 SF3B1 MACF1 ZCCHC2 PHIP	4.79e-05	200	88	5	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN14 KANK4 PAQR5 DPP3	1.62e-04	138	88	4	a88c3ae56b0af60f6e87cabade4f21e2bbb336f2
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD8-Tnaive/CM_CD8\|GI_small-bowel / Manually curated celltypes from each tissue	ATP8A2 ACTN1 PLK4 SORL1	1.76e-04	141	88	4	b2857b73fd754b879b922c7720b5ac3024976822
ToppCell	droplet-Heart-nan-24m-Hematologic-red_blood_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GCG ZCCHC2 PLK4	1.86e-04	56	88	3	55337ff90621e1fea4d747ae2559c0fa61b38dce
ToppCell	COVID-19-kidney-Lymphatic_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ADAM19 ZNF521 TNFRSF11A RALGAPA2	2.12e-04	148	88	4	f777aa1674e898e2594b2b7c029d3d05dda04df9
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BLM PRPF8 PLK4 ATP10D	2.17e-04	149	88	4	65778f19599b4955c0a16f0121237656449431fb
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Myeloid-neutrophil\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4D ADAM19 ACTN1 SORL1	2.23e-04	150	88	4	6e806a028c0519489151c181d9907e05289e27e0
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	HIF1A AFF2 TEX14 NEB	2.34e-04	152	88	4	18194f757d319958f26e5a91f56d89f25711236f
ToppCell	343B-Lymphocytic-CD4_T-cell-Treg_cell_1\|343B / Donor, Lineage, Cell class and subclass (all cells)	FOXO1 HIVEP1 STAM ATP10D	2.52e-04	155	88	4	a4ff78e2efc6fe9a513bb2b64e5848f2ce65a09f
ToppCell	Control-B_naive-1\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	SLF1 MACF1 ERBIN SORL1	2.52e-04	155	88	4	0a78d1cab2bdba2dc8a74cdf35b5a0192370c4b5
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-plasmacytoid_dendritic_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4D ADAM19 PAQR5 LRP8	2.65e-04	157	88	4	fc127e7720649e746f3d3f5c2e9e63784767106a
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-plasmacytoid_dendritic_cells\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4D ADAM19 PAQR5 LRP8	2.65e-04	157	88	4	66a191cef4aa00811bb04462310d012610006f85
ToppCell	severe_COVID-19-pDC\|World / disease group, cell group and cell class (v2)	LGMN C5orf34 DTNA ZNF521	2.78e-04	159	88	4	e1c48c4ceda116826819ff9adeed7bad6a58844d
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-mature_NK_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BRIP1 TEX14 NEB RYR3	2.78e-04	159	88	4	4000ed0d3b7d488722bcd0042fa2ff4405aaab82
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-Natural_Killer_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BRIP1 TEX14 NEB RYR3	2.78e-04	159	88	4	7619d0d49738dd08daf01b42664691a5323aa793
ToppCell	10x5'-bone_marrow-Mast\|bone_marrow / Manually curated celltypes from each tissue	PAQR5 ZNF521 ATP10D RYR3	2.78e-04	159	88	4	c3d3570e83c5d25cc92fa3a7a8f0dc2f89a72913
ToppCell	severe_COVID-19-pDC\|severe_COVID-19 / disease group, cell group and cell class (v2)	LGMN C5orf34 DTNA ZNF521	2.78e-04	159	88	4	ea5088d27e42b8850455764d53b757ea8d8f14bc
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4D NEXMIF PAQR5 LRP8	2.85e-04	160	88	4	e9e52532131cdc3fb01e81cfc046e3f670cc8e75
ToppCell	356C-Fibroblasts-Fibroblast-G-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	CRIM1 ATP8A2 KANK4 MACF1	2.85e-04	160	88	4	0293b244c063a62819690bf22bbc2681f8d15252
ToppCell	356C-Fibroblasts-Fibroblast-G\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	CRIM1 ATP8A2 KANK4 MACF1	2.85e-04	160	88	4	3eaae86fa08f7651021316f8e5811bf48055591e
ToppCell	droplet-Lung-nan-3m-Myeloid-Interstitial_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TANC2 LGMN ADAM19 TNFRSF11A	2.92e-04	161	88	4	f1d3287d9cb4e0eec99b3509f5dc4b87ae8c8cc9
Disease	Refractory anemia with ringed sideroblasts	TET2 SF3B1	8.79e-06	2	88	2	C1264195
Disease	myelodysplastic syndrome (implicated_via_orthology)	TET2 SF3B1 PRPF8	1.14e-05	15	88	3	DOID:0050908 (implicated_via_orthology)
Disease	progressive familial intrahepatic cholestasis (implicated_via_orthology)	ATP10B ATP10D	2.63e-05	3	88	2	DOID:0070221 (implicated_via_orthology)
Disease	hepatocellular carcinoma (is_marker_for)	FOXO1 TET2 HIF1A SF3B1 SLCO1B3 ZFHX3 PLK4	3.36e-05	301	88	7	DOID:684 (is_marker_for)
Disease	Cerebrovascular accident	COL3A1 SH3PXD2A ZFHX3 PRPF8	3.61e-05	62	88	4	C0038454
Disease	MYELODYSPLASTIC SYNDROME	BLM TET2 BRIP1 SF3B1	4.90e-05	67	88	4	C3463824
Disease	MYELODYSPLASTIC SYNDROME	TET2 SF3B1	8.74e-05	5	88	2	614286
Disease	Myelodysplastic syndrome	TET2 SF3B1	8.74e-05	5	88	2	cv:C3463824
Disease	Leukemia, Myelocytic, Acute	BLM FOXO1 TET2 BRIP1 SF3B1	1.73e-04	173	88	5	C0023467
Disease	creatinine measurement	SPATA7 TET2 HIF1A BRIP1 PTPN14 NCOA7 ZFHX3 NEB INTS8 EPAS1 SORL1	1.81e-04	995	88	11	EFO_0004518
Disease	mental or behavioural disorder	HNF1B ADAM19 ATP8A2 PAQR5 PHF8	2.03e-04	179	88	5	EFO_0000677
Disease	syndromic X-linked intellectual disability (implicated_via_orthology)	HUWE1 PHF8	2.43e-04	8	88	2	DOID:0060309 (implicated_via_orthology)
Disease	breast ductal carcinoma (is_marker_for)	SLCO1B3 PLK4	2.43e-04	8	88	2	DOID:3007 (is_marker_for)
Disease	Colorectal Carcinoma	COL3A1 TET2 MLH3 ADAM19 SLCO1B3 STAM ZNF804A PHIP SORL1	2.49e-04	702	88	9	C0009402
Disease	FEV/FEC ratio	FOXO1 TET2 C5orf34 ADAM19 CRIM1 SH3PXD2A ERCC6L2 SLC26A9 ZFHX3 NEB ASAP1 SORL1	2.83e-04	1228	88	12	EFO_0004713
Disease	bladder neck obstruction (biomarker_via_orthology)	COL3A1 HIF1A	3.12e-04	9	88	2	DOID:13948 (biomarker_via_orthology)
Disease	body weight	CCNE1 FOXO1 TET2 HNF1B PTPN14 HIVEP1 CRIM1 NEXMIF ZNF521 ZFHX3 HUWE1 EPAS1	3.60e-04	1261	88	12	EFO_0004338
Disease	serum metabolite measurement	CCNE1 TANC2 LGMN CRIM1 ZNF655 NCOA7 ZFHX3 CBS KYAT1 ATP10D	5.11e-04	945	88	10	EFO_0005653
Disease	Prostatic Neoplasms	FOXO1 TET2 HNF1B HIF1A SF3B1 NCOA7 ZFHX3 IL17RD	5.12e-04	616	88	8	C0033578
Disease	Malignant neoplasm of prostate	FOXO1 TET2 HNF1B HIF1A SF3B1 NCOA7 ZFHX3 IL17RD	5.12e-04	616	88	8	C0376358
Disease	bronchopulmonary dysplasia (biomarker_via_orthology)	HIF1A EPAS1	5.69e-04	12	88	2	DOID:11650 (biomarker_via_orthology)
Disease	Acute Cerebrovascular Accidents	SH3PXD2A ZFHX3 PRPF8	5.70e-04	54	88	3	C0751956
Disease	Papillary Renal Cell Carcinoma	TET2 HNF1B ZNF804A EPAS1	5.94e-04	128	88	4	C1306837
Disease	Renal Cell Carcinoma	TET2 HNF1B ZNF804A EPAS1	5.94e-04	128	88	4	C0007134
Disease	Sarcomatoid Renal Cell Carcinoma	TET2 HNF1B ZNF804A EPAS1	5.94e-04	128	88	4	C1266043
Disease	Chromophobe Renal Cell Carcinoma	TET2 HNF1B ZNF804A EPAS1	5.94e-04	128	88	4	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	TET2 HNF1B ZNF804A EPAS1	5.94e-04	128	88	4	C1266044
Disease	breastfeeding duration	ZCCHC2 TMEM181	7.82e-04	14	88	2	EFO_0006864
Disease	lung non-small cell carcinoma (is_implicated_in)	TET2 HIF1A ZFHX3 EPAS1	8.09e-04	139	88	4	DOID:3908 (is_implicated_in)
Disease	serum IgG glycosylation measurement	LGMN FAM81B TOPAZ1 ERCC6L2 RALGAPA2 ZNF804A EPAS1	9.73e-04	523	88	7	EFO_0005193
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	TET2 HNF1B ZNF804A EPAS1	1.02e-03	148	88	4	C0279702
Disease	common carotid intimal medial thickness	ATP8A2 ERCC6L2 RYR3	1.07e-03	67	88	3	EFO_0004860
Disease	cognitive function measurement	CCNE1 TANC2 SEMA4D HIVEP1 MAN2A1 CRIM1 ZNF521 GCG TEX14 ZCCHC2 ZNF804A RYR3	1.11e-03	1434	88	12	EFO_0008354
Disease	chronotype measurement	TANC2 SEMA4D HIVEP1 CRIM1 DTNA ZNF521 TEX14 ZCCHC2 ZNF804A	1.27e-03	882	88	9	EFO_0008328
Disease	colorectal cancer (is_marker_for)	TET2 HIF1A BRIP1 ZFHX3	1.27e-03	157	88	4	DOID:9256 (is_marker_for)
Disease	polycystic kidney disease (biomarker_via_orthology)	HIF1A EPAS1	1.45e-03	19	88	2	DOID:0080322 (biomarker_via_orthology)
Disease	heart failure, diabetes mellitus, stroke, atrial fibrillation, mortality, coronary artery disease, cancer	DNAH2 ZFHX3	1.61e-03	20	88	2	EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004352, MONDO_0004992
Disease	Nystagmus	AFF2 ATP10B	1.78e-03	21	88	2	HP_0000639
Disease	pulmonary hypertension (biomarker_via_orthology)	HIF1A EPAS1 RYR3	1.78e-03	80	88	3	DOID:6432 (biomarker_via_orthology)
Disease	hepatocellular carcinoma (is_implicated_in)	TET2 SF3B1 ZFHX3 RYR3	2.14e-03	181	88	4	DOID:684 (is_implicated_in)
Disease	heart failure	BRIP1 ZFHX3 PHIP EPAS1	2.31e-03	185	88	4	EFO_0003144
Disease	forced expiratory volume	TET2 ADAM19 CRIM1 SH3PXD2A ERCC6L2 IL17RD ANGPTL1 PHIP	2.47e-03	789	88	8	EFO_0004314
Disease	Hypertensive disease	COL3A1 HIF1A GCG CBS	2.55e-03	190	88	4	C0020538
Disease	Acute monocytic leukemia	BLM BRIP1	2.73e-03	26	88	2	C0023465
Disease	Endogenous Hyperinsulinism	COL3A1 GCG	2.73e-03	26	88	2	C1257963
Disease	Exogenous Hyperinsulinism	COL3A1 GCG	2.73e-03	26	88	2	C1257964
Disease	Compensatory Hyperinsulinemia	COL3A1 GCG	2.73e-03	26	88	2	C1257965
Disease	calcium measurement	CCNE1 TET2 DNAH2 PAQR5 MACF1 ZFHX3 ZCCHC2	2.74e-03	628	88	7	EFO_0004838
Disease	ovarian carcinoma	SEMA4D HNF1B BRIP1 ZFHX3 ZNF804A	2.77e-03	321	88	5	EFO_0001075
Disease	phosphatidylinositol measurement	KANK4 PAQR5 SLCO1B3	2.91e-03	95	88	3	EFO_0010230
Disease	acute kidney failure (implicated_via_orthology)	HIF1A EPAS1	2.94e-03	27	88	2	DOID:3021 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
HATESSEMAQGLAYK	C2orf16	156	Q68DN1
TENQSYAKHSANMNF	ERBIN	1016	Q96RT1
YHALDSENMTKSHQN	EPAS1	281	Q99814
SKIVQTYHVNMAGTN	ACTN1	576	P12814
GSYEMTNQHVKQNGK	CTDSPL2	111	Q05D32
AQKYHDNAQLITGMS	ADAM19	291	Q9H013
VEKQLYNHMGSDTTV	ADAM2	186	Q99965
YNHMGSDTTVVAQKV	ADAM2	191	Q99965
GNYDEMKNLLTNHSN	AFF2	76	P51816
HFSSSELMQKVSGYQ	CCNE1	306	P24864
AAASESNNYMNHVAK	GLCE	56	O94923
SNNYMNHVAKQQSEE	GLCE	61	O94923
QQAKEAGHSVSGIYM	ANGPTL1	281	O95841
ALMGVYHEKAQNQES	CALML6	96	Q8TD86
VVYTGHDTKLMQNST	ATP8A2	286	Q9NTI2
VIYAGHETKAMLNNS	ATP10B	286	O94823
VVYAGHETKAMLNNS	ATP10D	291	Q9P241
TAFKSLQEQNSHDAM	INTS8	911	Q75QN2
SAQNEATSYHQKHMI	PAQR5	211	Q9NXK6
AHEKVLSFYNVSQMG	OTOA	451	Q7RTW8
CYSSKDGQNHMNVVQ	IL17RD	361	Q8NFM7
QSGSHNSDVQMLDVY	MAN2A1	121	Q16706
MGAMNHDTNYSFQVQ	MGME1	276	Q9BQP7
HHDMFTKGQVTTGQY	HIF1A	291	Q16665
KGQLLHVDATTSMQY	KIAA1109	436	Q2LD37
SGYISSEAHYNKNMQ	MLH3	236	Q9UHC1
KAYAANSHQGQMLAQ	DPP3	266	Q9NY33
QMNEDKRHSQGTFTS	GCG	46	P01275
GAQSSLQEVYHKSMT	PSMA5	176	P28066
QSHNFDSAMKVTSQG	RALGAPA2	1576	Q2PPJ7
FYSSATAKTQHNGMN	HUWE1	2196	Q7Z6Z7
MSQNFHTSYAETLGK	MACF1	646	Q9UPN3
TMQNEYQSGFKSIHD	FAM81B	401	Q96LP2
HSKDFTNNDMNQGTS	BRIP1	91	Q9BX63
NSVMSTYGSQASHNK	FOXO1	501	Q12778
MHNLAASKSSTAAYQ	BLM	571	P54132
VNSYTMKDTAAHGTI	CARD14	721	Q9BXL6
NTAMQNLAQHSGYSV	GAB4	246	Q2WGN9
IQYHSTGKSSQRQMV	CBS	516	P35520
SGFYSMQKQNHLQAD	CRIM1	1016	Q9NZV1
QKEDSQSRQGGYSMH	ASAP1	301	Q9ULH1
SQRHMIYEESGNKST	MAP7D3	576	Q8IWC1
GHQTLVMYNAESKGT	CDH26	656	Q8IXH8
AGGSHSNQHQMKEYT	DTNA	276	Q9Y4J8
VDHQNKAGYTAVMIT	KANK4	851	Q5T7N3
HCKNSIAYMDQASGN	COL3A1	1371	P02461
MNKTNQVYAANEDHN	ERCC6L2	1031	Q5T890
HQNMNSIEIYSGDGS	C5orf34	346	Q96MH7
TGKESVHTYQQMVQA	DNAH2	576	Q9P225
HYANEDSKMGSTVTA	LRP8	811	Q14114
YMGVYETVNQNTKAH	MCMBP	81	Q9BTE3
QKLAMDAYSSNQTHS	HNF1B	311	P35680
SVKVMTVNYNTHGEL	MRPS25	26	P82663
KVYGQVSLNDSHNQM	SORL1	91	Q92673
VAVEKSYSHQSMQST	TEX14	1056	Q8IWB6
IQSQVSQHVGSMFYK	SAMD7	381	Q7Z3H4
ANKHGYDVDSNQEMI	SLC26A9	356	Q7LBE3
HGTMEYTAGNQDTLN	NCOA7	111	Q8NI08
FATHTAAMVQQYGKR	NCOA7	671	Q8NI08
GLYAQAEMSNKASDH	MRM3	291	Q9HC36
YVIALHMTTAGKTNQ	RCVRN	86	P35243
LQQSSHNFKMESSNY	NEXMIF	871	Q5QGS0
QHAVSGDFMLNQYTK	KYAT1	51	Q16773
ELANMQLQGSHNYST	PTPN14	541	Q15678
NTSQSMHVGEFNQKL	SLC12A1	881	Q13621
VAHSMASKYQSSQGD	TANC2	1636	Q9HCD6
TYVNENGEKITSMTH	TGM4	306	P49221
STAEEVFSHGKYMQS	SEMA4D	331	Q92854
VFSHGKYMQSTTVEQ	SEMA4D	336	Q92854
SDNAHSVKQQNTMKY	PLK4	531	O00444
SAHGDYMQNNESSLI	ZCCHC2	316	Q9C0B9
HYAQDCKQSSMEANQ	ZCCHC2	1141	Q9C0B9
VINYKDMNHTNSYGI	PRPF8	1016	Q6P2Q9
HQQFMTSGFEDKQST	USP51	321	Q70EK9
FSHGTRNNSAKENME	PHIP	1566	Q8WWQ0
GATVTHNAYEEKMEN	SAGE2P	291	A6NJ88
AQDGTTMYIHNKVHN	TMEM181	241	Q9P2C4
VTHKTFGTQNSNADM	RYR3	1271	Q15413
QTASAVVQHMSLGVY	SF3B1	1186	O75533
NAQAEMGKNHSSASF	SH3PXD2A	676	Q5TCZ1
FHMQKTGNGSAVQTT	ZNF521	1041	Q96K83
KYMEQQYGQSASHAN	SLCO1B3	361	Q9NPD5
SVQFSSVKGDNNHDM	SPATA7	566	Q9P0W8
VAGNAQMSHLQSYSL	STAM	416	Q92783
KMRNTFGSHTYENQK	SLF1	281	Q9BQI6
HTSDVMQEKNSANGA	ZNF350	446	Q9GZX5
NVAGEHQSTDSKYME	TOPAZ1	896	Q8N9V7
KYDMSFNQNSASGKH	ZNF655	161	Q8N720
MDTYSHQALKTGSFQ	PHF8	561	Q9UPP1
YSKSSEFETHNVQMG	TET2	791	Q6N021
SYTVHMSAAQKNEQG	HIVEP1	261	P15822
KNEQGAMQSASHLYH	HIVEP1	271	P15822
MSSENYLQKEVDSGH	TNFRSF11A	416	Q9Y6Q6
LSMAKHFGINQTSYE	ZFHX3	3006	Q15911
KHMSQNQAVKRGYNS	ZNF804A	746	Q7Z570
HTNTSHVMQYGNKTI	LGMN	261	Q99538
TAAKMAQDVATNVNY	NEB	1391	P20929