Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprolactin receptor binding

GH1 GH2 CSH1 CSH2

6.10e-0871314GO:0005148
GeneOntologyMolecularFunctiongrowth hormone receptor binding

GH1 GH2 CSH1 CSH2

3.60e-07101314GO:0005131
GeneOntologyMolecularFunctionATP hydrolysis activity

ABCA2 DNAH10 ERCC6L ATAD5 MCM7 YTHDC2 CHD8 MDN1 FBH1 HELZ2 ATP12A AQR

3.44e-0544113112GO:0016887
GeneOntologyMolecularFunctionsteroid 11-beta-monooxygenase activity

CYP11B1 CYP11B2

4.27e-0521312GO:0004507
GeneOntologyMolecularFunctioncorticosterone 18-monooxygenase activity

CYP11B1 CYP11B2

4.27e-0521312GO:0047783
GeneOntologyMolecularFunctionATP-dependent activity

ABCA2 DNAH10 ERCC6L MYO7B ATAD5 MCM7 YTHDC2 CHD8 MDN1 FBH1 HELZ2 ATP12A AQR SLC27A3

5.22e-0561413114GO:0140657
GeneOntologyMolecularFunctionhormone receptor binding

GH1 GH2 CSH1 CSH2

7.04e-05341314GO:0051427
GeneOntologyMolecularFunctionhelicase activity

ERCC6L MCM7 YTHDC2 CHD8 FBH1 HELZ2 AQR

8.35e-051581317GO:0004386
GeneOntologyMolecularFunctionRNA polymerase I core binding

RRN3P2 RRN3

2.54e-0441312GO:0001042
GeneOntologyMolecularFunctionDNA translocase activity

ERCC6L FBH1

4.22e-0451312GO:0015616
GeneOntologyMolecularFunctionprostaglandin E receptor activity

PTGER1 PTGER3

4.22e-0451312GO:0004957
GeneOntologyMolecularFunctionpolyubiquitin modification-dependent protein binding

PRPF8 PARP10 ATRIP UBQLN3

6.09e-04591314GO:0031593
GeneOntologyMolecularFunction3'-5' RNA helicase activity

YTHDC2 AQR

6.30e-0461312GO:0034458
GeneOntologyMolecularFunctionK63-linked polyubiquitin modification-dependent protein binding

PRPF8 PARP10 ATRIP

6.42e-04261313GO:0070530
GeneOntologyMolecularFunctionRNA polymerase binding

RRN3P2 YTHDC2 NEDD4 RRN3

8.79e-04651314GO:0070063
GeneOntologyMolecularFunctionhistone demethylase activity

KDM5A FBXL19 KDM2B

1.08e-03311313GO:0032452
GeneOntologyMolecularFunctionpyrimidine nucleoside transmembrane transporter activity

SLC22A1 SLC28A2

1.17e-0381312GO:0015214
GeneOntologyMolecularFunctionprotein demethylase activity

KDM5A FBXL19 KDM2B

1.19e-03321313GO:0140457
GeneOntologyMolecularFunctionpyrophosphatase activity

EFL1 ABCA2 DNAH10 ERCC6L ATAD5 ENPP1 MCM7 YTHDC2 CHD8 MDN1 FBH1 HELZ2 ATP12A AQR

1.24e-0383913114GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

EFL1 ABCA2 DNAH10 ERCC6L ATAD5 ENPP1 MCM7 YTHDC2 CHD8 MDN1 FBH1 HELZ2 ATP12A AQR

1.25e-0384013114GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

EFL1 ABCA2 DNAH10 ERCC6L ATAD5 ENPP1 MCM7 YTHDC2 CHD8 MDN1 FBH1 HELZ2 ATP12A AQR

1.25e-0384013114GO:0016818
GeneOntologyMolecularFunctionRNA polymerase I general transcription initiation factor activity

RRN3P2 RRN3

1.49e-0391312GO:0001181
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

ERCC6L ATAD5 MCM7 CHD8 FBH1

1.51e-031271315GO:0008094
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

EFL1 ABCA2 DNAH10 ERCC6L ATAD5 MCM7 YTHDC2 CHD8 MDN1 FBH1 HELZ2 ATP12A AQR

1.77e-0377513113GO:0017111
GeneOntologyMolecularFunctionnucleoside transmembrane transporter activity

SLC22A1 SLC28A2

1.86e-03101312GO:0005337
GeneOntologyMolecularFunctionunmethylated CpG binding

FBXL19 KDM2B

1.86e-03101312GO:0045322
GeneOntologyMolecularFunctionRNA polymerase I core promoter sequence-specific DNA binding

RRN3P2 RRN3

2.26e-03111312GO:0001164
GeneOntologyMolecularFunctionprostaglandin receptor activity

PTGER1 PTGER3

2.26e-03111312GO:0004955
GeneOntologyMolecularFunctionmodification-dependent protein binding

KDM5A CHD8 PRPF8 PARP10 ATRIP UBQLN3

2.41e-032061316GO:0140030
GeneOntologyMolecularFunctionprostanoid receptor activity

PTGER1 PTGER3

2.70e-03121312GO:0004954
GeneOntologyBiologicalProcesshormone biosynthetic process

CYP11B1 CYP11B2 GPR42 CYP27B1 GH1 GH2 CSH1 CSH2

6.35e-08831338GO:0042446
GeneOntologyBiologicalProcessregulation of hormone biosynthetic process

GPR42 CYP27B1 GH1 GH2 CSH1 CSH2

1.07e-07361336GO:0046885
GeneOntologyBiologicalProcesspositive regulation of steroid hormone biosynthetic process

GH1 GH2 CSH1 CSH2

1.13e-06131334GO:0090031
GeneOntologyBiologicalProcessregulation of hormone metabolic process

GPR42 CYP27B1 GH1 GH2 CSH1 CSH2

1.97e-06581336GO:0032350
GeneOntologyBiologicalProcesspositive regulation of hormone biosynthetic process

GH1 GH2 CSH1 CSH2

5.94e-06191334GO:0046886
GeneOntologyBiologicalProcesssteroid biosynthetic process

ABCA2 CYP11B1 CYP11B2 CYP27B1 GH1 GH2 HSD3B7 CSH1 CSH2

8.72e-062091339GO:0006694
GeneOntologyBiologicalProcessregulation of response to nutrient levels

CYP27B1 GH1 GH2 CSH1 CSH2

1.15e-05461335GO:0032107
GeneOntologyBiologicalProcessregulation of steroid hormone biosynthetic process

GH1 GH2 CSH1 CSH2

1.59e-05241334GO:0090030
GeneOntologyBiologicalProcessneural precursor cell proliferation

SOX10 GH1 GH2 IGF2BP1 CEP120 CSH1 CSH2 KDM2B LHX5

2.07e-052331339GO:0061351
GeneOntologyBiologicalProcessgrowth hormone receptor signaling pathway

GH1 GH2 CSH1 CSH2

2.21e-05261334GO:0060396
GeneOntologyBiologicalProcesspositive regulation of hormone metabolic process

GH1 GH2 CSH1 CSH2

2.21e-05261334GO:0032352
GeneOntologyBiologicalProcesscellular response to growth hormone stimulus

GH1 GH2 CSH1 CSH2

2.58e-05271334GO:0071378
GeneOntologyBiologicalProcessneuroblast proliferation

SOX10 GH1 GH2 CSH1 CSH2 LHX5

5.81e-051041336GO:0007405
GeneOntologyBiologicalProcessregulation of steroid biosynthetic process

ABCA2 CYP27B1 GH1 GH2 CSH1 CSH2

6.46e-051061336GO:0050810
GeneOntologyBiologicalProcessfibroblast proliferation

RASGRF1 CD248 RRN3P2 TSC2 PARP10 RRN3 PDGFC

8.14e-051601337GO:0048144
GeneOntologyBiologicalProcesshormone metabolic process

ENPP1 CYP11B1 CYP11B2 GPR42 CYP27B1 GH1 GH2 CSH1 CSH2

1.01e-042861339GO:0042445
GeneOntologyBiologicalProcesspositive regulation of steroid biosynthetic process

GH1 GH2 CSH1 CSH2

1.03e-04381334GO:0010893
GeneOntologyBiologicalProcessphotoreceptor cell outer segment organization

PCARE ROM1 CNGB1

1.13e-04151333GO:0035845
GeneOntologyBiologicalProcessresponse to growth hormone

GH1 GH2 CSH1 CSH2

1.39e-04411334GO:0060416
GeneOntologyBiologicalProcesspositive regulation of steroid metabolic process

GH1 GH2 CSH1 CSH2

1.53e-04421334GO:0045940
GeneOntologyBiologicalProcesssteroid metabolic process

ABCA2 ENPP1 CYP11B1 CYP11B2 CYP27B1 GH1 GH2 HSD3B7 CSH1 CSH2

1.66e-0437613310GO:0008202
GeneOntologyBiologicalProcesspositive regulation of multicellular organism growth

GH1 GH2 CSH1 CSH2

2.38e-04471334GO:0040018
GeneOntologyBiologicalProcessregulation of steroid metabolic process

ABCA2 CYP27B1 GH1 GH2 CSH1 CSH2

2.44e-041351336GO:0019218
GeneOntologyBiologicalProcessregulation of blood volume by renal aldosterone

CYP11B1 CYP11B2

2.46e-0441332GO:0002017
GeneOntologyBiologicalProcessregulation of intracellular steroid hormone receptor signaling pathway

GH1 GH2 CSH1 CSH2 CNOT2

2.50e-04871335GO:0033143
GeneOntologyBiologicalProcessnuclear receptor-mediated steroid hormone signaling pathway

NEDD4 GH1 GH2 CSH1 CSH2 CNOT2

2.54e-041361336GO:0030518
GeneOntologyBiologicalProcessnuclear receptor-mediated signaling pathway

CYP27B1 NEDD4 GH1 GH2 CSH1 CSH2 CNOT2

3.42e-042021337GO:0141193
GeneOntologyBiologicalProcessregulation of receptor internalization

SUSD4 TBC1D5 NEDD4 GH1 SCRIB

3.76e-04951335GO:0002090
GeneOntologyBiologicalProcessD-glucose transmembrane transport

ENPP1 TSC2 GH1 GH2 CSH1 CSH2

4.00e-041481336GO:1904659
GeneOntologyBiologicalProcesshexose transmembrane transport

ENPP1 TSC2 GH1 GH2 CSH1 CSH2

4.45e-041511336GO:0008645
GeneOntologyBiologicalProcessmonosaccharide transmembrane transport

ENPP1 TSC2 GH1 GH2 CSH1 CSH2

4.94e-041541336GO:0015749
GeneOntologyBiologicalProcesssteroid hormone receptor signaling pathway

NEDD4 GH1 GH2 CSH1 CSH2 CNOT2

5.11e-041551336GO:0043401
GeneOntologyBiologicalProcessregulation of receptor-mediated endocytosis

ABCA2 SUSD4 TBC1D5 NEDD4 GH1 SCRIB

5.29e-041561336GO:0048259
GeneOntologyBiologicalProcessresponse to food

GH1 GH2 CSH1 CSH2

5.35e-04581334GO:0032094
GeneOntologyBiologicalProcesspositive regulation of receptor signaling pathway via JAK-STAT

GH1 GH2 CSH1 CSH2

5.35e-04581334GO:0046427
GeneOntologyBiologicalProcessdetection of light stimulus involved in visual perception

PCARE ROM1 CNGB1

5.43e-04251333GO:0050908
GeneOntologyBiologicalProcessdetection of light stimulus involved in sensory perception

PCARE ROM1 CNGB1

5.43e-04251333GO:0050962
GeneOntologyBiologicalProcessregulation of D-glucose transmembrane transport

ENPP1 GH1 GH2 CSH1 CSH2

5.96e-041051335GO:0010827
GeneOntologyCellularComponentgrowth hormone receptor complex

GH1 GH2 CSH1 CSH2

2.33e-0861334GO:0070195
MousePhenodecreased pituitary gland weight

GH1 GH2 CSH1 CSH2

2.48e-0781104MP:0008938
MousePhenoabsent somatotrophs

GH1 GH2 CSH1 CSH2

4.44e-0791104MP:0008330
MousePhenoabsent lactotrophs

GH1 GH2 CSH1 CSH2

4.44e-0791104MP:0008333
MousePhenoabnormal pituitary gland size

CYP11B1 CYP11B2 GH1 GH2 CSH1 CSH2

8.62e-07421106MP:0008936
MousePhenoincreased circulating ghrelin level

GH1 GH2 CSH1 CSH2

1.71e-06121104MP:0011612
MousePhenoabnormal pituitary gland weight

GH1 GH2 CSH1 CSH2

1.71e-06121104MP:0008937
MousePhenoabnormal circulating ghrelin level

GH1 GH2 CSH1 CSH2

4.63e-06151104MP:0011611
MousePhenodecreased lactotroph cell number

GH1 GH2 CSH1 CSH2

7.98e-06171104MP:0008332
MousePhenoabnormal lactotroph morphology

GH1 GH2 CSH1 CSH2

1.28e-05191104MP:0008323
MousePhenodecreased somatotroph cell number

GH1 GH2 CSH1 CSH2

1.96e-05211104MP:0008329
MousePhenoincreased brown adipose tissue amount

GH1 GH2 CSH1 CSH2 HDC

2.09e-05431105MP:0000005
MousePhenosmall adenohypophysis

GH1 GH2 CSH1 CSH2

2.86e-05231104MP:0008321
MousePhenoabnormal somatotroph morphology

GH1 GH2 CSH1 CSH2

3.42e-05241104MP:0008322
MousePhenoincreased white adipose tissue amount

GH1 GH2 CSH1 CSH2 HDC

5.33e-05521105MP:0000008
MousePhenoabnormal urine progesterone level

CYP11B1 CYP11B2

6.14e-0521102MP:0011545
MousePhenoabnormal urine deoxycorticosterone level

CYP11B1 CYP11B2

6.14e-0521102MP:0011552
MousePhenodecreased urine corticosterone level

CYP11B1 CYP11B2

6.14e-0521102MP:0011550
MousePhenoincreased urine deoxycorticosterone level

CYP11B1 CYP11B2

6.14e-0521102MP:0011553
MousePhenoincreased urine progesterone level

CYP11B1 CYP11B2

6.14e-0521102MP:0011546
MousePhenodelayed vaginal opening

GH1 GH2 CSH1 CSH2

6.42e-05281104MP:0002636
MousePhenodisproportionate dwarf

GH1 GH2 IGF2BP1 CSH1 CSH2

8.32e-05571105MP:0002427
MousePhenosmall pituitary gland

GH1 GH2 CSH1 CSH2

8.50e-05301104MP:0005361
MousePhenoabnormal timing of vaginal opening

GH1 GH2 CSH1 CSH2

9.70e-05311104MP:0020150
MousePhenoincreased neural tube apoptosis

RRN3P2 NEDD4 RRN3 KDM2B

1.25e-04331104MP:0012505
MousePhenoabnormal circulating hormone level

CAND2 RASGRF1 CD248 CYP11B1 CYP11B2 GPR42 CYP27B1 PTGER1 PTGER3 GH1 GH2 KCNA3 CSH1 CSH2 HELZ2 TRAPPC10 PAPPA BBS12 HDC

1.51e-0495411019MP:0005418
MousePhenoincreased renin activity

CYP11B1 CYP11B2 PTGER1

1.62e-04141103MP:0005582
MousePhenoincreased circulating hormone level

CD248 CYP11B1 CYP11B2 GPR42 CYP27B1 GH1 GH2 CSH1 CSH2 HELZ2 TRAPPC10 PAPPA BBS12 HDC

1.73e-0457811014MP:0014456
MousePhenoabnormal iris transillumination

ESYT1 HPS5

1.83e-0431102MP:0012122
MousePhenoabnormal hormone level

CAND2 RASGRF1 CD248 CYP11B1 CYP11B2 GPR42 CYP27B1 PTGER1 PTGER3 GH1 GH2 KCNA3 CSH1 CSH2 HELZ2 TRAPPC10 PAPPA HPS5 BBS12 HDC

2.40e-04107311020MP:0003953
MousePhenodecreased spleen weight

TRIM73 GH1 GH2 CSH1 CSH2 TRIM74

2.64e-041131106MP:0004953
MousePhenoabnormal adrenocorticotropin level

CYP11B1 CYP11B2 PTGER1 PTGER3

2.94e-04411104MP:0003966
MousePhenofetal growth retardation

CUL7 BIRC6 NEDD4 IGF2BP1 GCN1 UTF1

3.05e-041161106MP:0004201
MousePhenodecreased heart weight

YTHDC2 GH1 GH2 CSH1 CSH2 ARHGAP33

3.34e-041181106MP:0002834
MousePhenoabnormal adrenal gland zona glomerulosa morphology

CYP11B1 CYP11B2

3.64e-0441102MP:0008293
MousePhenodecreased urine aldosterone level

CYP11B1 CYP11B2

3.64e-0441102MP:0011541
MousePhenoabnormal urine aldosterone level

CYP11B1 CYP11B2

3.64e-0441102MP:0011539
MousePhenodecreased foot pigmentation

SOX10 HPS5

3.64e-0441102MP:0011568
MousePhenoabnormal urine corticosterone level

CYP11B1 CYP11B2

3.64e-0441102MP:0011548
MousePhenothickened long bone epiphysis

CYP27B1 SLC39A13

3.64e-0441102MP:0000132
MousePhenodecreased urine hormone level

CYP11B1 CYP11B2

3.64e-0441102MP:0014459
MousePhenoimpaired glucose tolerance

RASGRF1 CYP11B1 CYP11B2 GPR42 CHD8 NEDD4 GH1 GH2 CSH1 CSH2 COMMD9 HDC

3.89e-0448011012MP:0005293
MousePhenoabnormal brown adipose tissue amount

GH1 GH2 CSH1 CSH2 HDC

4.64e-04821105MP:0001778
MousePhenoabnormal renin activity

CYP11B1 CYP11B2 PTGER1

4.90e-04201103MP:0005581
MousePhenoincreased hormone level

CD248 CYP11B1 CYP11B2 GPR42 CYP27B1 GH1 GH2 CSH1 CSH2 HELZ2 TRAPPC10 PAPPA BBS12 HDC

4.94e-0464111014MP:0014454
MousePhenodelayed sexual maturation

GH1 GH2 CSH1 CSH2

5.86e-04491104MP:0001938
MousePhenoincreased adrenal gland zona fasciculata size

CYP11B1 CYP11B2

6.04e-0451102MP:0014286
MousePhenoabnormal pituitary gland morphology

CYP11B1 CYP11B2 GH1 GH2 CSH1 CSH2

6.84e-041351106MP:0000633
MousePhenoabnormal fetal growth/weight/body size

LAMA5 CUL7 BIRC6 NEDD4 IGF2BP1 KDM2B SCRIB GCN1 UTF1

7.90e-043121109MP:0004197
MousePhenooliguria

CYP11B1 CYP11B2 PTGER1

8.51e-04241103MP:0003620
MousePhenouterus adenomyosis

CYP11B1 CYP11B2

9.02e-0461102MP:0009221
MousePhenoincreased urine hormone level

CYP11B1 CYP11B2

9.02e-0461102MP:0014458
MousePhenoadrenal gland hyperplasia

CYP11B1 CYP11B2

9.02e-0461102MP:0009078
MousePhenodecreased fasting circulating glucose level

GH1 GH2 PAOX ATRIP CSH1 CSH2 HELZ2

1.01e-032001107MP:0013278
MousePhenodecreased circulating mineral level

CAND2 ENPP1 CYP11B1 CYP11B2 CYP27B1 SEC31B SLC26A1 AKAP9 NUB1 ATP12A

1.02e-0339111010MP:0014548
MousePhenoabnormal urine homeostasis

CYP11B1 CYP11B2 CYP27B1 LAMA5 PTGER1 PTGER3 SLC26A1 PRODH2 SLC22A1 ATP12A HPS5

1.10e-0346611011MP:0009643
MousePhenoabnormal urine hormone level

CYP11B1 CYP11B2

1.26e-0371102MP:0011538
MousePhenohypochlorhydria

TRIM73 TRIM74

1.26e-0371102MP:0008001
MousePhenopituitary gland hyperplasia

CYP11B1 CYP11B2

1.26e-0371102MP:0000635
MousePhenoabnormal kidney weight

CYP11B1 CYP11B2 GH1 GH2 CSH1 CSH2 ATP12A

1.27e-032081107MP:0002707
MousePhenodecreased bone mineral density

ENPP1 CYP27B1 YTHDC2 CUL7 SLC39A13 NEDD4 GH1 GH2 CSH1 CSH2 PAPPA

1.30e-0347611011MP:0000063
DomainSOMATOTROPIN_2

GH1 GH2 CSH1 CSH2

3.12e-0861284PS00338
DomainSOMATOTROPIN_1

GH1 GH2 CSH1 CSH2

3.12e-0861284PS00266
DomainHormone_1

GH1 GH2 CSH1 CSH2

3.12e-0861284PF00103
DomainSomatotropin

GH1 GH2 CSH1 CSH2

7.25e-0871284IPR001400
DomainSomatotropin_CS

GH1 GH2 CSH1

3.11e-0651283IPR018116
DomainCyt_P450_mitochondrial

CYP11B1 CYP11B2

4.66e-0521282IPR002399
DomainProstglndn_DP_rcpt

PTGER1 PTGER3

1.39e-0431282IPR001244
DomainPHD_4

FBXL19 KDM2B

1.39e-0431282PF16866
DomainHEAT

PPP4R1 CAND2 RPTOR GCN1

3.24e-04481284PF02985
Domain4_helix_cytokine_core

GH1 GH2 CSH1 CSH2

4.10e-04511284IPR012351
DomainAAA

ABCA2 DNAH10 ATAD5 MCM7 MDN1 HELZ2

4.75e-041441286SM00382
DomainAAA+_ATPase

ABCA2 DNAH10 ATAD5 MCM7 MDN1 HELZ2

4.75e-041441286IPR003593
Domain-

EFL1 ABCA2 DNAH10 ERCC6L MYO7B MFHAS1 ATAD5 MCM7 YTHDC2 CHD8 MDN1 FBH1 HELZ2 AQR

6.01e-04746128143.40.50.300
DomainHEAT

PPP4R1 CAND2 RPTOR GCN1

6.71e-04581284IPR000357
DomainLRR_8

MFHAS1 LRRC4 TLR8 LGR6 SCRIB GP9

1.17e-031711286PF13855
DomainProstanoid_rcpt

PTGER1 PTGER3

1.27e-0381282IPR008365
Domain4_helix_cytokine-like_core

GH1 GH2 CSH1 CSH2

1.67e-03741284IPR009079
Domain-

MFHAS1 FBXL19 LRRC4 TLR8 KDM2B LGR6 SCRIB GP9

1.68e-0332112883.80.10.10
DomainL_dom-like

MFHAS1 FBXL19 LRRC4 TLR8 KDM2B LGR6 SCRIB GP9

1.92e-033281288IPR032675
DomainP-loop_NTPase

EFL1 ABCA2 DNAH10 ERCC6L MYO7B MFHAS1 ATAD5 MCM7 YTHDC2 CHD8 MDN1 FBH1 HELZ2 AQR

2.03e-0384812814IPR027417
DomainZF_CXXC

FBXL19 KDM2B

2.46e-03111282PS51058
DomainZnf_CXXC

FBXL19 KDM2B

2.46e-03111282IPR002857
Domainzf-CXXC

FBXL19 KDM2B

2.46e-03111282PF02008
DomainARM-like

PPP4R1 CAND2 TSC2 CUL7 RPTOR GCN1 TARBP1

2.61e-032701287IPR011989
DomainLeu-rich_rpt

MFHAS1 FBXL19 LRRC4 TLR8 LGR6 SCRIB GP9

2.67e-032711287IPR001611
DomainATPase_dyneun-rel_AAA

DNAH10 MDN1

4.02e-03141282IPR011704
DomainAAA_5

DNAH10 MDN1

4.02e-03141282PF07728
DomainLRR_1

MFHAS1 FBXL19 LRRC4 TLR8 LGR6 SCRIB

4.02e-032191286PF00560
Domain-

PPP4R1 CAND2 TSC2 CUL7 RPTOR GCN1

4.30e-0322212861.25.10.10
Domain-

GH1 GH2 CSH1

4.87e-035012831.20.1250.10
DomainFBOX

FBXL19 FBH1 KDM2B

5.44e-03521283SM00256
DomainLRRNT

LRRC4 LGR6 GP9

5.74e-03531283PF01462
DomainCyt_P450_CS

CYP11B1 CYP11B2 CYP27B1

5.74e-03531283IPR017972
DomainHEAT_type_2

PPP4R1 GCN1

5.93e-03171282IPR021133
DomainSUSHI

SUSD4 CD248 PAPPA

6.69e-03561283PS50923
PathwayREACTOME_PROLACTIN_RECEPTOR_SIGNALING

GH1 GH2 CSH1 CSH2

2.13e-06131074MM14516
PathwayREACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING

GH1 GH2 CSH1 CSH2

5.32e-06161074MM15710
PathwayBIOCARTA_LONGEVITY_PATHWAY

GH1 GH2 CSH1 CSH2

1.11e-05191074MM1513
PathwayREACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN

GH1 GH2 CSH1 CSH2

1.38e-05201074MM15070
PathwayBIOCARTA_AKT_PATHWAY

GH1 GH2 CSH1 CSH2

4.12e-05261074MM1345
PathwayBIOCARTA_TFF_PATHWAY

GH1 GH2 CSH1 CSH2

6.44e-05291074MM1522
PathwayBIOCARTA_GH_PATHWAY

GH1 GH2 CSH1 CSH2

1.08e-04331074MM1404
PathwayREACTOME_PROLACTIN_RECEPTOR_SIGNALING

GH1 GH2 CSH1

1.81e-04151073M552
Pubmed

The human growth hormone gene family: nucleotide sequences show recent divergence and predict a new polypeptide hormone.

GH1 GH2 CSH1 CSH2

2.30e-10413747169009
Pubmed

Central growth hormone action regulates metabolism during pregnancy.

GH1 GH2 CSH1 CSH2

1.15e-095137431479305
Pubmed

Molecular evolution of growth hormone and receptor in the guinea-pig, a mammal unresponsive to growth hormone.

GH1 GH2 CSH1 CSH2

1.15e-095137410767558
Pubmed

Heterogeneous growth hormone (GH) gene mutations in familial GH deficiency.

GH1 GH2 CSH1 CSH2

1.15e-09513748496314
Pubmed

Exploring endocrine GH pattern in mice using rank plot analysis and random blood samples.

GH1 GH2 CSH1 CSH2

1.15e-095137421045135
Pubmed

Analysis of gender difference of cardiac risk biomarkers using hGH-transgenic mice.

GH1 GH2 CSH1 CSH2

1.15e-095137416508206
Pubmed

Rescue of pituitary function in a mouse model of isolated growth hormone deficiency type II by RNA interference.

GH1 GH2 CSH1 CSH2

1.15e-095137418006625
Pubmed

Growth hormone overexpression in the central nervous system results in hyperphagia-induced obesity associated with insulin resistance and dyslipidemia.

GH1 GH2 CSH1 CSH2

1.15e-095137415616010
Pubmed

Nitric oxide stimulates embryonic somatotroph differentiation and growth hormone mRNA and protein expression through a cyclic guanosine monophosphate-independent mechanism.

GH1 GH2 CSH1 CSH2

1.15e-095137419019400
Pubmed

The Effects of 20-kDa Human Placental GH in Male and Female GH-deficient Mice: An Improved Human GH?

GH1 GH2 CSH1 CSH2

1.15e-095137432556100
Pubmed

High frequency of mammary adenocarcinomas in metallothionein promoter-human growth hormone transgenic mice created from two different strains of mice.

GH1 GH2 CSH1 CSH2

1.15e-09513741525063
Pubmed

Obesity and elevated plasma leptin concentration in oMT1A-o growth hormone transgenic mice.

GH1 GH2 CSH1 CSH2

1.15e-095137411346667
Pubmed

Cardiac contractile function is enhanced in isolated ventricular myocytes from growth hormone transgenic mice.

GH1 GH2 CSH1 CSH2

1.15e-095137412010633
Pubmed

Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesis.

GH1 GH2 CSH1 CSH2

1.15e-095137417626886
Pubmed

Growth hormone prevents the development of autoimmune diabetes.

GH1 GH2 CSH1 CSH2

1.15e-095137424218587
Pubmed

Regulation of rapid signal transducer and activator of transcription-5 phosphorylation in the resting cells of the growth plate and in the liver by growth hormone and feeding.

GH1 GH2 CSH1 CSH2

1.15e-095137419359380
Pubmed

Body composition of inactivated growth hormone (oMt1a-oGH) transgenic mice: generation of an obese phenotype.

GH1 GH2 CSH1 CSH2

1.15e-09513749546108
Pubmed

Transgene transmission to progeny by oMt1a-oGH transgenic mice.

GH1 GH2 CSH1 CSH2

1.15e-095137416201410
Pubmed

Growth hormone stimulates the selective trafficking of thymic CD4+CD8- emigrants to peripheral lymphoid organs.

GH1 GH2 CSH1 CSH2

1.15e-095137415316240
Pubmed

Genes that prolong life: relationships of growth hormone and growth to aging and life span.

GH1 GH2 CSH1 CSH2

1.15e-095137411487592
Pubmed

Overexpressed growth hormone (GH) synergistically promotes carcinogen-initiated liver tumour growth by promoting cellular proliferation in emerging hepatocellular neoplasms in female and male GH-transgenic mice.

GH1 GH2 CSH1 CSH2

1.15e-095137411318985
Pubmed

Involvement of insulin-like growth factor-1 in the effect of caloric restriction: regulation of plasma adiponectin and leptin.

GH1 GH2 CSH1 CSH2

1.15e-095137417301034
Pubmed

Growth hormone action in the developing neural retina: a proteomic analysis.

GH1 GH2 CSH1 CSH2

1.15e-095137418203262
Pubmed

Identification of the glomerular podocyte as a target for growth hormone action.

GH1 GH2 CSH1 CSH2

1.15e-095137417272398
Pubmed

Glucose homeostasis and insulin sensitivity in growth hormone-transgenic mice: a cross-sectional analysis.

GH1 GH2 CSH1 CSH2

1.15e-095137420707609
Pubmed

Assignment of the porcine growth hormone gene to chromosome 12.

GH1 GH2 CSH1 CSH2

1.15e-09513742249485
Pubmed

Growth hormone stimulates adipogenesis of 3T3-L1 cells through activation of the Stat5A/5B-PPARgamma pathway.

GH1 GH2 CSH1 CSH2

1.15e-095137417242167
Pubmed

A single injection of double-stranded adeno-associated viral vector expressing GH normalizes growth in GH-deficient mice.

GH1 GH2 CSH1 CSH2

1.15e-095137418180319
Pubmed

Induction of mammary adenocarcinomas in metallothionein promoter-human growth hormone transgenic mice.

GH1 GH2 CSH1 CSH2

1.15e-09513741874564
Pubmed

Cloning and characterisation of the GH gene from the common dolphin (Delphinus delphis).

GH1 GH2 CSH1 CSH2

1.15e-095137412225773
Pubmed

Growth Hormone Deficiency and Excess Alter the Gut Microbiome in Adult Male Mice.

GH1 GH2 CSH1 CSH2

1.15e-095137432100023
Pubmed

The related genes encoding growth hormone and prolactin have been dispersed to chromosomes 10 and 17 in the rat.

GH1 GH2 CSH1 CSH2

1.15e-09513743780533
Pubmed

High, persistent hepatocellular proliferation and apoptosis precede hepatocarcinogenesis in growth hormone transgenic mice.

GH1 GH2 CSH1 CSH2

1.15e-095137410395045
Pubmed

Effect of genetic background on growth of mice hemizygous for wild-type or dwarf mutated bovine growth hormone transgenes.

GH1 GH2 CSH1 CSH2

1.15e-095137424190208
Pubmed

Brief report: short stature caused by a mutant growth hormone.

GH1 GH2 CSH1 CSH2

1.15e-09513748552145
Pubmed

Promotion of Joint Degeneration and Chondrocyte Metabolic Dysfunction by Excessive Growth Hormone in Mice.

GH1 GH2 CSH1 CSH2

1.15e-095137436762426
Pubmed

High molecular weight isoforms of growth hormone in cells of the immune system.

GH1 GH2 CSH1 CSH2

1.15e-095137421741628
Pubmed

Structure of the growth hormone-encoding gene and its promoter in mice.

GH1 GH2 CSH1 CSH2

1.15e-09513748647448
Pubmed

Thiol-Disulfide Exchange in Human Growth Hormone.

GH1 GH2 CSH1 CSH2

1.15e-095137426887678
Pubmed

Transgenic mice expressing bovine GH develop arthritic disorder and self-antibodies.

GH1 GH2 CSH1 CSH2

1.15e-095137410810296
Pubmed

The role of growth hormone in fetal mouse reproductive tract differentiation.

GH1 GH2 CSH1 CSH2

1.15e-09513748756530
Pubmed

GH Knockout Mice Have Increased Subcutaneous Adipose Tissue With Decreased Fibrosis and Enhanced Insulin Sensitivity.

GH1 GH2 CSH1 CSH2

1.15e-095137431099824
Pubmed

Somatotropin transgenic mice have reduced jejunal active glucose transport rates.

GH1 GH2 CSH1 CSH2

1.15e-09513747965203
Pubmed

Hot spots for growth hormone gene deletions in homologous regions outside of Alu repeats.

GH1 GH2 CSH1 CSH2

1.15e-09513741980158
Pubmed

Vitamin D3 cannot revert desensitization of growth hormone (GH)-induced STAT5-signaling in GH-overexpressing mice non-calcemic tissues.

GH1 GH2 CSH1 CSH2

1.15e-095137417881271
Pubmed

Neural growth hormone implicated in body weight sex differences.

GH1 GH2 CSH1 CSH2

1.15e-095137423861378
Pubmed

Growth hormone increases low-density lipoprotein receptor and HMG-CoA reductase mRNA expression in mesangial cells.

GH1 GH2 CSH1 CSH2

1.15e-095137412759574
Pubmed

Growth hormone production and action in N1E-115 neuroblastoma cells.

GH1 GH2 CSH1 CSH2

1.15e-095137419301152
Pubmed

Adipocyte insensitivity to insulin in growth hormone-transgenic mice.

GH1 GH2 CSH1 CSH2

1.15e-095137411350075
Pubmed

Transgenic mice overexpressing growth hormone (GH) have reduced or increased cardiac apoptosis through activation of multiple GH-dependent or -independent cell death pathways.

GH1 GH2 CSH1 CSH2

1.15e-095137418617616
Pubmed

Adipocytokines and the regulation of lipid metabolism in growth hormone transgenic and calorie-restricted mice.

GH1 GH2 CSH1 CSH2

1.15e-095137417347312
Pubmed

Growth hormone and fertility in oMt1a-oGH transgenic mice.

GH1 GH2 CSH1 CSH2

1.15e-095137411570960
Pubmed

Promoter shuffling has occurred during the evolution of the vertebrate growth hormone gene.

GH1 GH2 CSH1 CSH2

1.15e-095137410974531
Pubmed

Pleiotropic effects of growth hormone signaling in aging.

GH1 GH2 CSH1 CSH2

1.15e-095137421852148
Pubmed

Body composition, bone mass and microstructural analysis in GH-transgenic mice reveals that skeletal changes are specific to bone compartment and gender.

GH1 GH2 CSH1 CSH2

1.15e-095137412175649
Pubmed

Transgenic mice reveal novel activities of growth hormone in wound repair, angiogenesis, and myofibroblast differentiation.

GH1 GH2 CSH1 CSH2

1.15e-095137415070902
Pubmed

Hepatocellular alterations and dysregulation of oncogenic pathways in the liver of transgenic mice overexpressing growth hormone.

GH1 GH2 CSH1 CSH2

1.15e-095137423428905
Pubmed

A novel missense mutation in the mouse growth hormone gene causes semidominant dwarfism, hyperghrelinemia, and obesity.

GH1 GH2 CSH1 CSH2

1.15e-095137414726450
Pubmed

UV photodegradation of murine growth hormone: chemical analysis and immunogenicity consequences.

GH1 GH2 CSH1 CSH2

1.15e-095137424758742
Pubmed

Consequences of overexpression of growth hormone in transgenic mice on liver cytochrome P450 enzymes.

GH1 GH2 CSH1 CSH2

1.15e-095137410076541
Pubmed

Overgrowth of skin in growth hormone transgenic mice depends on the presence of male gonads.

GH1 GH2 CSH1 CSH2

1.15e-095137410594738
Pubmed

Hypoxia and cytoplasmic alkalinization upregulate growth hormone expression in lymphocytes.

GH1 GH2 CSH1 CSH2

1.15e-095137423639351
Pubmed

Pituitary growth hormone network responses are sexually dimorphic and regulated by gonadal steroids in adulthood.

GH1 GH2 CSH1 CSH2

1.15e-095137421098290
Pubmed

Cardiac expression of adenine nucleotide translocase-1 in transgenic mice overexpressing bovine GH.

GH1 GH2 CSH1 CSH2

1.15e-095137417761891
Pubmed

Age-related changes in body composition of bovine growth hormone transgenic mice.

GH1 GH2 CSH1 CSH2

1.15e-095137418948397
Pubmed

The human growth hormone locus: nucleotide sequence, biology, and evolution.

GH1 GH2 CSH1 CSH2

3.44e-09613742744760
Pubmed

Growth hormone, acting in part through the insulin-like growth factor axis, rescues developmental, but not metabolic, activity in the mammary gland of mice expressing a single allele of the prolactin receptor.

GH1 GH2 CSH1 CSH2

3.44e-096137412399427
Pubmed

Transgenic mice over-expressing galanin exhibit pituitary adenomas and increased secretion of galanin, prolactin and growth hormone.

GH1 GH2 CSH1 CSH2

3.44e-096137414596666
Pubmed

GH modulates hepatic epidermal growth factor signaling in the mouse.

GH1 GH2 CSH1 CSH2

3.44e-096137420032199
Pubmed

Growth inhibition in giant growth hormone transgenic mice by overexpression of insulin-like growth factor-binding protein-2.

GH1 GH2 CSH1 CSH2

3.44e-096137411316754
Pubmed

The use of transgenic mice to analyze the role of accessory factor two in the regulation of phosphoenolpyruvate carboxykinase (GTP) gene transcription during diabetes.

GH1 GH2 CSH1 CSH2

3.44e-096137411309401
Pubmed

The rise in growth hormone during starvation does not serve to maintain glucose levels or lean mass but is required for appropriate adipose tissue response in female mice.

GH1 GH2 CSH1 CSH2

3.44e-096137423150490
Pubmed

Nucleotide sequence of mouse prolactin and growth hormone mRNAs and expression of these mRNAs during pregnancy.

GH1 GH2 CSH1 CSH2

3.44e-09613742991252
Pubmed

Genetic dissection of IGF1-dependent and -independent effects of permanent GH excess on postnatal growth and organ pathology of mice.

GH1 GH2 CSH1 CSH2

3.44e-096137425017732
Pubmed

Third party data gene data set of eutherian growth hormone genes.

GH1 GH2 CSH1 CSH2

3.44e-096137426697363
Pubmed

Role of growth hormone in the genetic change of mice divergently selected for body weight and fatness.

GH1 GH2 CSH1 CSH2

3.44e-096137410689811
Pubmed

Effects of long-term treatment with growth hormone-releasing peptide-2 in the GHRH knockout mouse.

GH1 GH2 CSH1 CSH2

3.44e-096137415985453
Pubmed

Phosphorylation of sterol regulatory element-binding protein (SREBP)-1a links growth hormone action to lipid metabolism in hepatocytes.

GH1 GH2 CSH1 CSH2

3.44e-096137420863500
Pubmed

An early reduction in GH peak amplitude in preproghrelin-deficient male mice has a minor impact on linear growth.

GH1 GH2 CSH1 CSH2

3.44e-096137424949662
Pubmed

Growth Hormone Pulses and Liver Gene Expression Are Differentially Regulated by the Circadian Clock Gene Bmal1.

GH1 GH2 CSH1 CSH2

3.44e-096137433539533
Pubmed

Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice.

GH1 GH2 CSH1 CSH2

3.44e-096137420231469
Pubmed

Growth hormone resistance: clinical states and animal models.

GH1 GH2 CSH1 CSH2

3.44e-096137410556764
Pubmed

Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling.

GH1 GH2 CSH1 CSH2

3.44e-096137412208853
Pubmed

Involvement of growth hormone as a regulating factor in sex differences of mouse hepatic aldehyde oxidase.

GH1 GH2 CSH1 CSH2

3.44e-09613749175714
Pubmed

Disruption of growth hormone signaling retards early stages of prostate carcinogenesis in the C3(1)/T antigen mouse.

GH1 GH2 CSH1 CSH2

3.44e-096137416141391
Pubmed

Sex differences in thrombosis in mice are mediated by sex-specific growth hormone secretion patterns.

GH1 GH2 CSH1 CSH2

3.44e-096137418618017
Pubmed

Transcript abundance in mouse pituitaries with altered growth hormone expression quantified by reverse transcriptase polymerase chain reaction implicates transcription factor Zn-16 in gene regulation in vivo.

GH1 GH2 CSH1 CSH2

3.44e-096137412166626
Pubmed

Growth hormone expression in murine bone marrow cells is independent of the pituitary transcription factor Pit-1.

GH1 GH2 CSH1 CSH2

3.44e-09613749275086
Pubmed

Disruption of JAK2 in adipocytes impairs lipolysis and improves fatty liver in mice with elevated GH.

GH1 GH2 CSH1 CSH2

3.44e-096137423782652
Pubmed

Growth hormone is a positive regulator of adiponectin receptor 2 in 3T3-L1 adipocytes.

GH1 GH2 CSH1 CSH2

3.44e-096137414759511
Pubmed

Age related changes in gene expression within the cochlea of C57BL/6J mice.

GH1 GH2 CSH1 CSH2

3.44e-096137423010755
Pubmed

Acylated ghrelin is not required for the surge in pituitary growth hormone observed in pregnant mice.

GH1 GH2 CSH1 CSH2

3.44e-096137425645493
Pubmed

Administration of human insulin-like growth factor-binding protein-1 increases circulating levels of growth hormone in mice.

GH1 GH2 CSH1 CSH2

3.44e-096137415166120
Pubmed

Osteocalcin induces growth hormone/insulin-like growth factor-1 system by promoting testosterone synthesis in male mice.

GH1 GH2 CSH1 CSH2

3.44e-096137424691732
Pubmed

Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice.

GH1 GH2 CSH1 CSH2

3.44e-096137421725989
Pubmed

CTCF mutation at R567 causes developmental disorders via 3D genome rearrangement and abnormal neurodevelopment.

GH1 GH2 CSH1 CSH2

3.44e-096137438951485
Pubmed

Evidence that growth hormone exerts a feedback effect on stomach ghrelin production and secretion.

GH1 GH2 CSH1 CSH2

3.44e-096137414530511
Pubmed

Growth hormone controls lipolysis by regulation of FSP27 expression.

GH1 GH2 CSH1 CSH2

3.44e-096137430400015
Pubmed

Curated eutherian third party data gene data sets.

GH1 GH2 CSH1 CSH2

3.44e-096137426862561
Pubmed

Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes.

GH1 GH2 CSH1 CSH2

3.44e-096137421849508
Cytoband17q24.2

GH1 GH2 CSH1 CSH2

1.96e-0630137417q24.2
CytobandEnsembl 112 genes in cytogenetic band chr17q23

GH1 GH2 CSH1 CSH2

4.77e-041201374chr17q23
GeneFamilyGrowth hormone family

GH1 GH2 CSH1 CSH2

8.94e-0969141175
GeneFamilyCytochrome P450 family 11

CYP11B1 CYP11B2

7.49e-0539121007
GeneFamilyProstaglandin (prostanoid) receptors

PTGER1 PTGER3

8.82e-049912207
GeneFamilyUPF1 like RNA helicases

HELZ2 AQR

1.34e-03119121169
GeneFamilyZinc fingers CXXC-type

FBXL19 KDM2B

1.60e-0312912136
ToppCellMild|World / Disease group and Cell class

TRIM14 PARP10 KCNA3 ATRIP HELZ2 NUB1 ARHGEF3

2.43e-0619613675e4ed4a5a437cfa002b92775992a791e27aa4c27
ToppCellMild-CD8+_T_activated|World / Disease group and Cell class

PARP10 KCNA3 ATRIP HELZ2 NUB1 ARHGEF3 TARBP1

2.43e-06196136779632190e44fcef9d7c11d9b9e37f2ebf0e6e255
ToppCellMild-CD4+_T_activated|World / Disease group and Cell class

TRIM14 PARP10 KCNA3 ATRIP HELZ2 NUB1 ARHGEF3

2.43e-061961367417b4fc2e4388f34c410576131b02936f93e46b6
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

N4BP3 NEDD4 RASIP1 PARP10 HELZ2 NUB1 ARHGEF3

2.78e-06200136789821a264e872ed53e08e9d3609d5cc5c314503e
ToppCell11.5-Distal-Immune-Hematopoietic,_B_Cells|Distal / Age, Tissue, Lineage and Cell class

ARHGAP30 PTGER3 DNAAF3 IGLL1 HDC GP9

1.64e-051751366d8ca8fbe5309dab293c335b32f1b138edfdd0b07
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SEC16B SUSD4 FBXL19 IGF2BP1 ROM1 ARHGAP33

1.64e-05175136696219e58dcb327fd27190be78193e7a0d611e62b
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SEC16B SUSD4 FBXL19 IGF2BP1 ROM1 ARHGAP33

1.64e-051751366cb974fbebe8cb58c7d3f7defabb4e056f2fee5fa
ToppCellCOVID-mDC1-|COVID / Condition, Cell_class and T cell subcluster

DNAH10 RASGRF1 ENPP1 LAMA5 PTGER3 HPS5

1.64e-05175136683a95d6fc2ddf3ec53f05825bbc982fb8d2ccd15
ToppCellCOVID-mDC1|COVID / Condition, Cell_class and T cell subcluster

DNAH10 RASGRF1 ENPP1 LAMA5 PTGER3 HPS5

1.64e-051751366b9280444016e21c28131a61df65cc5c56d402412
ToppCellfacs-Marrow-T-cells-3m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEC16B LAMA5 PTGER3 NEDD4 ROM1 HDC

1.81e-05178136641745a589567ca5ea6d06331f4c8da03595b5f5c
ToppCellfacs-Marrow-T-cells-3m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEC16B LAMA5 PTGER3 NEDD4 ROM1 HDC

1.81e-051781366eb940dd64c973f68bcaad6069d3bd56383329db5
ToppCelldroplet-Marrow-nan-18m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA2 ESYT1 PTGER3 NEDD4 ROM1 HDC

1.99e-051811366382337427be3c11ecd03e9fa2c2e831a9674c6a7
ToppCellNS-critical-d_0-4-Lymphoid-NKT-proliferating|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ERCC6L ATAD5 ENPP1 MCM7 ESPL1 ARHGAP33

2.54e-051891366d6bd46abb072b13a6b72f1ca25d19f218cceb1ff
ToppCellMild|World / Condition, Lineage, Cell class and cell subclass

TRIM14 KCNA3 AKAP9 ATRIP COMMD9 ARHGEF3

3.20e-051971366476b0d0389f9fcd4614f6bb1f494281f467f6730
Diseaseisolated growth hormone deficiency type II (implicated_via_orthology)

GH1 GH2 CSH1 CSH2

2.15e-0951364DOID:0060872 (implicated_via_orthology)
Diseaseisolated growth hormone deficiency (implicated_via_orthology)

GH1 GH2 CSH1 CSH2

1.49e-0871364DOID:0060870 (implicated_via_orthology)
Diseasecongenital hypothyroidism (biomarker_via_orthology)

GH1 GH2 CSH1 CSH2

4.17e-07141364DOID:0050328 (biomarker_via_orthology)
Diseaseosteoporosis (biomarker_via_orthology)

GH1 GH2 CSH1 CSH2

2.96e-06221364DOID:11476 (biomarker_via_orthology)
DiseaseGlucocorticoid-remediable aldosteronism

CYP11B1 CYP11B2

2.11e-0521362C1260386
Diseaseadrenal cortical adenoma (is_marker_for)

CYP11B1 CYP11B2

2.11e-0521362DOID:0050891 (is_marker_for)
Diseasetype 1 diabetes mellitus (implicated_via_orthology)

GH1 GH2 CSH1 CSH2

3.13e-05391364DOID:9744 (implicated_via_orthology)
Diseasecongenital adrenal hyperplasia (implicated_via_orthology)

CYP11B1 CYP11B2

6.31e-0531362DOID:0050811 (implicated_via_orthology)
DiseaseIGFBP-3 measurement

MFHAS1 TSC2 FCSK ATRIP

1.14e-04541364EFO_0004626
DiseaseX-03056--N-[3- 2-Oxopyrrolidin-1-yl propyl]acetamide measurement

PAOX SLC22A1

1.26e-0441362EFO_0021186
DiseaseCiliopathies

PCARE TSC2 DNAAF3 WDR35 BBS12

1.60e-041101365C4277690
Diseasesexual dimorphism measurement

ANKRD31 SEC16B DNAH10 RASGRF1 CD248 ATAD5 TSC2 DYSF GH1 PARP10 CEP120 CSH1 RRN3 PAPPA GCN1

1.85e-04110613615EFO_0021796
Diseasescavenger receptor class F member 1 measurement

PRPF8 ARHGEF3

2.09e-0451362EFO_0008276
Diseaseprimary hyperaldosteronism (is_implicated_in)

CYP11B1 CYP11B2

2.09e-0451362DOID:446 (is_implicated_in)
Diseaseaggressive behaviour measurement, ADHD symptom measurement

MFHAS1 BIRC6 HSD3B7 RPTOR

2.80e-04681364EFO_0007826, EFO_0007860
DiseaseConn Syndrome

CYP11B1 CYP11B2

3.13e-0461362C1384514
DiseaseAbnormality of vision

PIGB FCSK

3.13e-0461362C4025846
DiseaseHyperaldosteronism

CYP11B1 CYP11B2

3.13e-0461362C0020428
Diseaseheart septal defect

WDR7 YTHDC2

3.13e-0461362MONDO_0002078
DiseaseRetinitis pigmentosa

PCARE PRPF8 ROM1 CNGB1

3.87e-04741364cv:C0035334
Diseaseprotocadherin alpha-7 measurement

CYP11B1 CYP11B2

4.36e-0471362EFO_0801973
Diseaseacisoga measurement

PAOX SLC22A1

4.36e-0471362EFO_0800068
Diseaseprotein FAM163B measurement

CYP11B1 CYP11B2

7.43e-0491362EFO_0802936
Diseasesleep apnea

SEC16B CEP120 KDM2B

8.35e-04401363EFO_0003877
Diseaseandrostenedione measurement

CYP11B1 CYP11B2

9.26e-04101362EFO_0007972
DiseaseRussell-Silver syndrome

GH2 CSH1

9.26e-04101362C0175693
Diseasecell growth regulator with EF hand domain protein 1 measurement

CYP11B1 CYP11B2

1.13e-03111362EFO_0801461
Disease3-hydroxyanthranilate 3,4-dioxygenase measurement

CYP11B1 CYP11B2

1.13e-03111362EFO_0021862
DiseaseRetinitis Pigmentosa

PCARE PRPF8 ROM1 CNGB1

1.39e-031041364C0035334
Diseasevery low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio

ANKRD31 SEC16B DNAH10 MFHAS1 RRN3 HELZ2

1.44e-032641366EFO_0008317, EFO_0020944
DiseaseShort Rib-Polydactyly Syndrome

CEP120 WDR35

1.59e-03131362C0036996
DiseaseN-acetyl-isoputreanine measurement

PAOX SLC22A1

1.59e-03131362EFO_0800107
DiseaseSaldino-Noonan Syndrome

CEP120 WDR35

1.85e-03141362C0036069
DiseaseMajewski Syndrome

CEP120 WDR35

1.85e-03141362C0024507
DiseaseHOMA-B

CAND2 SLC22A1 IGLL1

2.11e-03551363EFO_0004469
DiseaseGeneralized hypotonia

PIGB FCSK

2.13e-03151362C1858120
Diseasecholesteryl esters to total lipids in large VLDL percentage

ANKRD31 RRN3 SLC22A1

2.22e-03561363EFO_0022250
Diseasecholesterol in IDL measurement

ANKRD31 RRN3 SLC22A1

2.46e-03581363EFO_0021899
Diseasepancreatic ductal carcinoma (is_marker_for)

MCM7 TSC2 KDM2B

2.84e-03611363DOID:3587 (is_marker_for)
DiseaseDisorder of eye

PCARE PRPF8 ROM1 BBS12 CNGB1

3.07e-032121365C0015397
DiseaseTourette syndrome, schizophrenia

DNAH10 TBC1D5

3.07e-03181362EFO_0004895, MONDO_0005090
Diseaseprion disease

MFHAS1 ATRIP

3.43e-03191362EFO_0004720
Diseasemetabolonic lactone sulfate measurement

MCM7 ZNF394

3.43e-03191362EFO_0800659
Diseasevery low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio

ANKRD31 SEC16B MFHAS1 RRN3 HELZ2

3.74e-032221365EFO_0008317, EFO_0020943
Diseasefree cholesterol in large VLDL measurement

ANKRD31 DNAH10 SLC22A1

3.86e-03681363EFO_0022265
Diseasetriglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement

ANKRD31 SEC16B MFHAS1 RRN3 HELZ2

3.96e-032251365EFO_0008317, EFO_0020947

Protein segments in the cluster

PeptideGeneStartEntry
LLLEEIRWSNPEFSL

ATAD5

946

Q96QE3
LARLLTAPELILDQW

ESYT1

561

Q9BSJ8
ERVFSPQELLWLDEL

SLC4A9

926

Q96Q91
DWRGELLLALQQVFL

AKAP9

3021

Q99996
ELLLLQERQRASEWP

CHD8

2141

Q9HCK8
DLWNFLDIPRSRLVK

ARHGEF3

251

Q9NR81
QLSEPLLWFILRVLD

BIRC6

3076

Q9NR09
LLRDRDWINQVYLPE

ACCS

366

Q96QU6
LNALLQWLLRPLVLY

HSD3B7

301

Q9H2F3
QRDDRWLLVALLVPT

CD248

681

Q9HCU0
LRQAWLENIRPVLVI

EFL1

131

Q7Z2Z2
EVPWTLQELEALLLR

BTBD11

96

A6QL63
EALLPTRRWFNTILD

AQR

261

O60306
LLLQLREELAAVWRE

ANKRD35

491

Q8N283
TLAPLDFLLQRKRLW

SLC22A18AS

26

Q8N1D0
LRQLPSLVNAWERAL

CCDC87

711

Q9NVE4
WERALKPIQLREALL

CCDC87

721

Q9NVE4
KPIQLREALLARLEW

CCDC87

726

Q9NVE4
EAWRRALDLVLLVLQ

BBS12

671

Q6ZW61
LPALRLLDLRWIEDV

FBXL19

531

Q6PCT2
QELLSQELWRRLLPG

PRODH2

516

Q9UF12
RLRRLLWDLEQQELP

RASIP1

936

Q5U651
PALIWQQQRELAELR

EDC4

951

Q6P2E9
RWLQVLGELQRLLLD

CDC42BPG

1056

Q6DT37
LTQFLREDRIQLWKP

NUB1

11

Q9Y5A7
LEDLIRYLEPERWQL

PDGFC

196

Q9NRA1
LEEKELPWRRLLFDQ

ANKRD31

26

Q8N7Z5
GEEWQRLRSLLAPLL

CYP27B1

131

O15528
LRDWNLIRDAATLIL

HDC

461

P19113
LLQAWGLILRANILE

MDN1

2861

Q9NU22
WILENDPTELDLRFI

NEDD4

1106

P46934
LFLWRELQEAPLSLA

GPAA1

561

O43292
LLTLWLDNNRIRYLP

MFHAS1

321

Q9Y4C4
LWSLIPNNDVRRLVS

LRRC37A5P

31

Q49AS3
AEALWELPSLQSLRL

LGR6

131

Q9HBX8
RNIPPQLRWEVLDSL

IGF2BP1

86

Q9NZI8
QFLRLLLLWVPASRG

IGKV6D-41

6

A0A0C4DH26
EGFLPRTLINLRVEW

ATP12A

891

P54707
ESLLQPESLRLDWLL

HPS5

911

Q9UPZ3
LLLIESWLEPVRFLR

CSH2

106

P0DML3
DLLFHQRIQISLWPR

FAM157A

86

C9JC47
LDPWVYILLRQAVLR

PTGER1

346

P34995
SLNQILDPWVYLLLR

PTGER3

336

P43115
RVILLENLTRFWPII

CUL7

931

Q14999
LPRRDFQRQVWLLFE

KCNA3

211

P22001
LSKLRELWLRNNPIE

LRRC4

146

Q9HBW1
PILDRFLLNVLDRAW

LHX5

11

Q9H2C1
FEERILAVLQWLQLP

ENPP1

346

P22413
LLPQLEQGLFDDLWR

GCN1

1816

Q92616
QLLRTLAEVERLLWE

LAMA5

2311

O15230
GNLLILITVWADPRL

OR10G3

41

Q8NGC4
DLELPRDAFTLQVWL

PAPPA

111

Q13219
LEFWKDQLAILLPVR

GPR42

171

O15529
LPRLKQELQQARWLD

KDM5A

891

P29375
QLPAALLSRFDLLWL

MCM7

506

P33993
LLSRFDLLWLIQDRP

MCM7

511

P33993
ALWPRDALLFAVDNL

GRIN3A

121

Q8TCU5
ARNLAIVWAPNLLRS

ARHGAP33

461

O14559
NQISLPRLVDLDWRV

COMMD9

116

Q9P000
VLEARQDLSLRPLIW

FCSK

561

Q8N0W3
QDLSLRPLIWAAVRE

FCSK

566

Q8N0W3
LRLWLEDRTPEALLQ

GP9

96

P14770
LDLLFHQRIQISLWP

FAM157B

86

P0CG42
WDPETLALLLREELQ

ESPL1

576

Q14674
LDRIIDIWILLQPEE

FBH1

781

Q8NFZ0
RQRWPLLLLGLAVVT

IGLL1

21

P15814
LSWLINRLPGLRDLV

KDM2B

1141

Q8NHM5
RLEEQLPWLSLRALK

DNAAF3

146

Q8N9W5
LQDTFLRIPLLVELW

CEP120

521

Q8N960
LGQPRDLLLLWRQAV

CROCC2

221

H7BZ55
EWRFNRLRLNPEVLS

CYP11B1

136

P15538
LDSVARNPQELWRFL

ABCA2

151

Q9BZC7
EWRFNRLRLNPDVLS

CYP11B2

136

P19099
LLLDSNIRLWVVLPI

EMC3

6

Q9P0I2
SRPDRVALETQWLQL

ATRIP

641

Q8WXE1
LLELVELQRWPEAAA

HELZ2

1831

Q9BYK8
ALVVLQELVRALWPL

CAND2

541

O75155
LLLIESWLEPVRFLR

CSH1

106

P0DML2
RIWQNDILEREIPLS

DNAH10

3376

Q8IVF4
RLREVWQALPLILFA

SLC22A1

486

O15245
LEEEDPWRSLQQLLL

SLC39A13

341

Q96H72
PAALEQAEDWLLRLR

DYSF

766

O75923
DLIIWIRLVPLQEEI

ERCC6L

366

Q2NKX8
AFRELPLQLLLDGQW

PTX4

346

Q96A99
LRQRFVASWALLPDV

OLFML2A

491

Q68BL7
EVLLQEVREDLAWPL

PCARE

241

A6NGG8
APRWLEEEAALQLAL

PARP10

646

Q53GL7
ARNLAIVWAPNLLRS

ARHGAP30

166

Q7Z6I6
READRLLSLWAPQVQ

PAOX

491

Q6QHF9
VQLLIWIPRLAQALL

PIGB

136

Q92521
FEQLISIILRLPWLN

RRN3

106

Q9NYV6
RLLFNDPDLREVWLN

DROSHA

1066

Q9NRR4
WRFRAELAEQLILLL

PPP4R1

756

Q8TF05
SLLLPWQNRLRNEIE

TCP11X1

121

B4DZS4
RLENVWLPLFLASEQ

RGS22

961

Q8NE09
LWKELVLFLRPRSQL

PIK3R6

296

Q5UE93
DRLPVIQLWDLRFAS

SEC31B

236

Q9NQW1
LPNLRELWLDRNQLS

SCRIB

196

Q14160
LLPEEWDEITLRFIN

SLC35F4

471

A4IF30
AIPARWLRSLELLFA

RASGRF1

701

Q13972
DWEGLLELLQARLPR

TRIOBP

1581

Q9H2D6
QSSARELRPLLVFIW

RPTOR

481

Q8N122
LWLALDTAQRPEQLI

SLC28A2

161

O43868
DTRPGLRLLLWLEQN

CNGB1

151

Q14028
LRRWADLLLVAPLDA

PPCDC

91

Q96CD2
LQLLAAVELFNRDWR

CNOT2

456

Q9NZN8
PLLERWLGNLLARQF

PRPF8

646

Q6P2Q9
LLLIQSWLEPVQLLR

GH2

106

P01242
LPNVSLAWVIEALRL

TRIM74

66

Q86UV6
QVLALLWPRFELILE

VPS52

471

Q8N1B4
WTLLQQFPRLELLDL

TLR8

681

Q9NR97
SRVRYWDLLLLIPNV

TPRA1

41

Q86W33
VREALQSDWLPFELL

UBXN6

366

Q9BZV1
IPLQLRGEVWALLLE

USP6NL

101

Q92738
RWLRPELLSKEQILE

ZNF394

91

Q53GI3
FLAILPEELQAWLRE

ZSCAN30

96

Q86W11
LQPRIRLAQGLWLLS

ROM1

11

Q03395
VRALVQDLLPATRWL

SLC26A1

46

Q9H2B4
LRWLPADLAFAVRAL

SLC27A3

26

Q5K4L6
NRLLEDPVIKRFLAW

SPDYE7P

56

Q495Y7
PQRLLAVILWFQLAL

SUSD4

26

Q5VX71
LWRLLNESDKRPFIE

SOX10

141

P56693
LLLIQSWLEPVQFLR

GH1

106

P01241
VWNNSRPIRLEEILE

PKHD1L1

346

Q86WI1
FEQLISIILRLPWLN

RRN3P2

106

A6NIE6
LFANVLEPVLDRDRW

nan

516

Q6ZUG5
LEPDWLAQLRRQLEQ

SEC16B

696

Q96JE7
PVLRFDALWQVLARD

TRIM14

301

Q14142
LEPLVGEQLLQLWER

YTHDC2

1406

Q9H6S0
LPNVSLAWVIEALRL

TRIM73

66

Q86UV7
RVWQTLLVLFPRLDQ

TARBP1

1171

Q13395
REFPLQDLLVVWDAL

TBC1D5

341

Q92609
LSQAPEAWRLFLLLA

TMEM129

86

A0AVI4
TLLLFLQRPWEVAQR

TRAPPC10

316

P48553
LQRPWEVAQRALELL

TRAPPC10

321

P48553
LARIPEWGQDLQLLL

TGM7

496

Q96PF1
PRLWRLLAEAALQKL

WDR35

696

Q9P2L0
WDLSVELQINPRALL

WDR7

46

Q9Y4E6
LQVLATEAPRLLLWF

UBQLN3

531

Q9H347
EWILLDPVQRNLYRD

ZNF560

26

Q96MR9
VAWDILLNIIERLLQ

TSC2

356

P49815
LQPAVWRALLLDRRQ

UTF1

76

Q5T230
PFTQVLEERQRLWLA

N4BP3

281

O15049
VVDAARLQWPLLFSR

MYO7B

1396

Q6PIF6