Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	monoatomic ion-gated channel activity	TMEM63B ASIC2 ASIC1	1.79e-05	31	33	3	GO:0022839
GeneOntologyMolecularFunction	extracellular matrix structural constituent	TINAGL1 HSPG2 FGG EFEMP2	2.52e-04	188	33	4	GO:0005201
GeneOntologyMolecularFunction	ligand-gated sodium channel activity	ASIC2 ASIC1	3.99e-04	18	33	2	GO:0015280
GeneOntologyMolecularFunction	structural molecule activity	TINAGL1 ERVK-5 HSPG2 ERVK-7 FGG ERVK-24 EFEMP2	5.31e-04	891	33	7	GO:0005198
GeneOntologyMolecularFunction	transforming growth factor beta binding	LTBP3 WFIKKN2	8.40e-04	26	33	2	GO:0050431
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	TMEM63B ASIC2 ASIC1	1.58e-03	140	33	3	GO:0099094
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-7 ERVK-24	1.70e-03	37	33	2	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-7 ERVK-24	1.79e-03	38	33	2	GO:0070001
GeneOntologyMolecularFunction	gated channel activity	TMEM63B KCNG3 ASIC2 ASIC1	2.15e-03	334	33	4	GO:0022836
GeneOntologyMolecularFunction	monoatomic cation channel activity	TMEM63B KCNG3 ASIC2 ASIC1	2.36e-03	343	33	4	GO:0005261
GeneOntologyMolecularFunction	sodium channel activity	ASIC2 ASIC1	3.34e-03	52	33	2	GO:0005272
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	TMEM63B ASIC2 ASIC1	3.92e-03	193	33	3	GO:0015276
GeneOntologyMolecularFunction	peptidase activity	TINAGL1 ADAM30 ERVK-7 PLG ERVK-24	4.12e-03	654	33	5	GO:0008233
GeneOntologyMolecularFunction	ligand-gated channel activity	TMEM63B ASIC2 ASIC1	4.15e-03	197	33	3	GO:0022834
GeneOntologyMolecularFunction	endopeptidase activity	ADAM30 ERVK-7 PLG ERVK-24	5.29e-03	430	33	4	GO:0004175
GeneOntologyCellularComponent	collagen-containing extracellular matrix	TINAGL1 HSPG2 LTBP3 FGG PLG EFEMP2	1.34e-04	530	32	6	GO:0062023
GeneOntologyCellularComponent	extracellular matrix	TINAGL1 HSPG2 LTBP3 FGG PLG EFEMP2	4.21e-04	656	32	6	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	TINAGL1 HSPG2 LTBP3 FGG PLG EFEMP2	4.28e-04	658	32	6	GO:0030312
GeneOntologyCellularComponent	blood microparticle	C3 FGG PLG	1.37e-03	144	32	3	GO:0072562
Domain	EGF_CA	HSPG2 NELL2 HEG1 LTBP3 EFEMP2	1.15e-06	122	29	5	SM00179
Domain	EGF-like_Ca-bd_dom	HSPG2 NELL2 HEG1 LTBP3 EFEMP2	1.24e-06	124	29	5	IPR001881
Domain	EGF_3	HSPG2 ADAM30 NELL2 HEG1 LTBP3 EFEMP2	1.39e-06	235	29	6	PS50026
Domain	EGF-like_dom	HSPG2 ADAM30 NELL2 HEG1 LTBP3 EFEMP2	1.94e-06	249	29	6	IPR000742
Domain	EGF_1	HSPG2 ADAM30 NELL2 HEG1 LTBP3 EFEMP2	2.23e-06	255	29	6	PS00022
Domain	EGF-like_CS	HSPG2 ADAM30 NELL2 HEG1 LTBP3 EFEMP2	2.55e-06	261	29	6	IPR013032
Domain	EGF_2	HSPG2 ADAM30 NELL2 HEG1 LTBP3 EFEMP2	2.78e-06	265	29	6	PS01186
Domain	EGF_CA	NELL2 HEG1 LTBP3 EFEMP2	9.11e-06	86	29	4	PF07645
Domain	EGF_Ca-bd_CS	NELL2 HEG1 LTBP3 EFEMP2	1.47e-05	97	29	4	IPR018097
Domain	EGF_CA	NELL2 HEG1 LTBP3 EFEMP2	1.59e-05	99	29	4	PS01187
Domain	ASX_HYDROXYL	NELL2 HEG1 LTBP3 EFEMP2	1.66e-05	100	29	4	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	NELL2 HEG1 LTBP3 EFEMP2	2.09e-05	106	29	4	IPR000152
Domain	EGF	HSPG2 NELL2 HEG1 LTBP3 EFEMP2	2.80e-05	235	29	5	SM00181
Domain	ENaC	ASIC2 ASIC1	4.87e-05	7	29	2	IPR004724
Domain	Na+channel_ASC_CS	ASIC2 ASIC1	6.48e-05	8	29	2	IPR020903
Domain	ASC	ASIC2 ASIC1	8.32e-05	9	29	2	PF00858
Domain	ASC	ASIC2 ASIC1	8.32e-05	9	29	2	PS01206
Domain	Na+channel_ASC	ASIC2 ASIC1	8.32e-05	9	29	2	IPR001873
Domain	Growth_fac_rcpt_	HSPG2 NELL2 LTBP3 EFEMP2	9.45e-05	156	29	4	IPR009030
Domain	VWC_out	MUC19 NELL2	3.92e-04	19	29	2	SM00215
Domain	NTR	C3 WFIKKN2	3.92e-04	19	29	2	PF01759
Domain	Netrin_module_non-TIMP	C3 WFIKKN2	3.92e-04	19	29	2	IPR018933
Domain	NTR	C3 WFIKKN2	5.77e-04	23	29	2	PS50189
Domain	Netrin_domain	C3 WFIKKN2	5.77e-04	23	29	2	IPR001134
Domain	cEGF	LTBP3 EFEMP2	7.39e-04	26	29	2	IPR026823
Domain	cEGF	LTBP3 EFEMP2	7.39e-04	26	29	2	PF12662
Domain	TIMP-like_OB-fold	C3 WFIKKN2	7.39e-04	26	29	2	IPR008993
Domain	VWC	MUC19 NELL2	1.58e-03	38	29	2	SM00214
Domain	VWFC_2	MUC19 NELL2	1.58e-03	38	29	2	PS50184
Domain	Laminin_G_2	HSPG2 NELL2	1.75e-03	40	29	2	PF02210
Domain	VWF_dom	MUC19 NELL2	1.93e-03	42	29	2	IPR001007
Domain	LamG	HSPG2 NELL2	2.11e-03	44	29	2	SM00282
Domain	Laminin_G	HSPG2 NELL2	3.65e-03	58	29	2	IPR001791
Domain	-	HSPG2 NELL2	9.51e-03	95	29	2	2.60.120.200
Pathway	WP_COVID19_THROMBOSIS_AND_ANTICOAGULATION	FGG PLG	4.86e-05	7	22	2	M39868
Pathway	KEGG_MEDICUS_REFERENCE_PLASMIN_MEDIATED_ACTIVATION_OF_LATENT_TGF_BETA	LTBP3 PLG	6.47e-05	8	22	2	M47850
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	HSPG2 LTBP3 FGG PLG EFEMP2	8.26e-05	300	22	5	M610
Pathway	BIOCARTA_FIBRINOLYSIS_PATHWAY	FGG PLG	1.52e-04	12	22	2	M2842
Pathway	BIOCARTA_FIBRINOLYSIS_PATHWAY	FGG PLG	1.52e-04	12	22	2	MM1398
Pathway	KEGG_COMPLEMENT_AND_COAGULATION_CASCADES	C3 FGG PLG	1.62e-04	69	22	3	M16894
Pathway	WP_COMPLEMENT_SYSTEM	C3 FGG PLG	4.29e-04	96	22	3	M39581
Pathway	BIOCARTA_AMI_PATHWAY	FGG PLG	4.34e-04	20	22	2	M15394
Pathway	WP_BLOOD_CLOTTING_CASCADE	FGG PLG	5.27e-04	22	22	2	M39480
Pathway	WP_BLOOD_CLOTTING_CASCADE	FGG PLG	5.77e-04	23	22	2	MM15936
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	LTBP3 FGG PLG EFEMP2	6.18e-04	258	22	4	MM14572
Pathway	REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_TRANSPORT_AND_UPTAKE_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS	C3 FGG PLG	9.05e-04	124	22	3	M27285
Pathway	PID_INTEGRIN2_PATHWAY	C3 FGG	9.20e-04	29	22	2	M169
Pathway	REACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES	LTBP3 EFEMP2	1.12e-03	32	22	2	MM14854
Pathway	REACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES	LTBP3 EFEMP2	1.50e-03	37	22	2	M27134
Pathway	REACTOME_ELASTIC_FIBRE_FORMATION	LTBP3 EFEMP2	1.66e-03	39	22	2	MM14601
Pathway	PID_UPA_UPAR_PATHWAY	FGG PLG	1.93e-03	42	22	2	M174
Pathway	WP_FIBRIN_COMPLEMENT_RECEPTOR_3_SIGNALING	FGG PLG	2.02e-03	43	22	2	M39744
Pathway	REACTOME_ELASTIC_FIBRE_FORMATION	LTBP3 EFEMP2	2.11e-03	44	22	2	M26969
Pubmed	Extracellular Fibrinogen-binding Protein (Efb) from Staphylococcus aureus Inhibits the Formation of Platelet-Leukocyte Complexes.	C3 FGG PLG	9.30e-08	10	33	3	26627825
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	TINAGL1 HSPG2 FGG PLG EFEMP2	5.12e-07	167	33	5	22159717
Pubmed	Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis.	ASIC2 ASIC1	8.73e-07	2	33	2	21307247
Pubmed	Localization and behaviors in null mice suggest that ASIC1 and ASIC2 modulate responses to aversive stimuli.	ASIC2 ASIC1	8.73e-07	2	33	2	24256442
Pubmed	Presynaptic release probability is increased in hippocampal neurons from ASIC1 knockout mice.	ASIC2 ASIC1	8.73e-07	2	33	2	18094106
Pubmed	ASIC subunit ratio and differential surface trafficking in the brain.	ASIC2 ASIC1	8.73e-07	2	33	2	26746198
Pubmed	Acid-sensing ion channel-1b in the stereocilia of mammalian cochlear hair cells.	ASIC2 ASIC1	8.73e-07	2	33	2	16951561
Pubmed	Acid-Sensing Ion Channel 1a Contributes to Airway Hyperreactivity in Mice.	ASIC2 ASIC1	8.73e-07	2	33	2	27820848
Pubmed	Acid-sensing ion channels (ASICs) are differentially modulated by anions dependent on their subunit composition.	ASIC2 ASIC1	8.73e-07	2	33	2	23135698
Pubmed	Characterization of acid-sensing ion channels in medium spiny neurons of mouse striatum.	ASIC2 ASIC1	8.73e-07	2	33	2	19376200
Pubmed	Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala.	ASIC2 ASIC1	8.73e-07	2	33	2	24889629
Pubmed	Acid sensing ion channels in dorsal spinal cord neurons.	ASIC2 ASIC1	8.73e-07	2	33	2	18256271
Pubmed	BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels.	ASIC2 ASIC1	8.73e-07	2	33	2	9037075
Pubmed	Upregulation of acid-sensing ion channel 1 protein expression by chronic administration of cocaine in the mouse striatum in vivo.	ASIC2 ASIC1	8.73e-07	2	33	2	19427358
Pubmed	Reduced plasminogen binding and delayed activation render γ'-fibrin more resistant to lysis than γA-fibrin.	FGG PLG	8.73e-07	2	33	2	25128532
Pubmed	Determinants of ion selectivity in ASIC1a- and ASIC2a-containing acid-sensing ion channels.	ASIC2 ASIC1	8.73e-07	2	33	2	31952079
Pubmed	Interplay between fibrinolysis and complement: plasmin cleavage of iC3b modulates immune responses.	C3 PLG	8.73e-07	2	33	2	25556624
Pubmed	Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing.	C3 PLG	8.73e-07	2	33	2	23969887
Pubmed	The interaction between the first transmembrane domain and the thumb of ASIC1a is critical for its N-glycosylation and trafficking.	ASIC2 ASIC1	8.73e-07	2	33	2	22046405
Pubmed	The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties.	ASIC2 ASIC1	8.73e-07	2	33	2	9360943
Pubmed	Acid-sensing ion channel (ASIC) 1a/2a heteromers have a flexible 2:1/1:2 stoichiometry.	ASIC2 ASIC1	8.73e-07	2	33	2	24847067
Pubmed	The Thumb Domain Mediates Acid-sensing Ion Channel Desensitization.	ASIC2 ASIC1	8.73e-07	2	33	2	27015804
Pubmed	Altered Expression Pattern of Acid-Sensing Ion Channel Isoforms in Piriform Cortex After Seizures.	ASIC2 ASIC1	8.73e-07	2	33	2	25744567
Pubmed	Changes in H+, K+, and Ca2+ Concentrations, as Observed in Seizures, Induce Action Potential Signaling in Cortical Neurons by a Mechanism That Depends Partially on Acid-Sensing Ion Channels.	ASIC2 ASIC1	8.73e-07	2	33	2	34720879
Pubmed	Differential regulation of locomotor activity to acute and chronic cocaine administration by acid-sensing ion channel 1a and 2 in adult mice.	ASIC2 ASIC1	8.73e-07	2	33	2	23644053
Pubmed	Acid-sensing ion channel 2 (ASIC2) modulates ASIC1 H+-activated currents in hippocampal neurons.	ASIC2 ASIC1	8.73e-07	2	33	2	14960591
Pubmed	Bacillus anthracis interacts with plasmin(ogen) to evade C3b-dependent innate immunity.	C3 PLG	8.73e-07	2	33	2	21464960
Pubmed	Differential localization of Acid-sensing ion channels 1 and 2 in human cutaneus pacinian corpuscles.	ASIC2 ASIC1	8.73e-07	2	33	2	20306292
Pubmed	ASIC2a and ASIC3 heteromultimerize to form pH-sensitive channels in mouse cardiac dorsal root ganglia neurons.	ASIC2 ASIC1	2.62e-06	3	33	2	19590043
Pubmed	Identification and Function of Acid-sensing Ion Channels in RAW 264.7 Macrophage Cells.	ASIC2 ASIC1	2.62e-06	3	33	2	30074209
Pubmed	Different contributions of ASIC channels 1a, 2, and 3 in gastrointestinal mechanosensory function.	ASIC2 ASIC1	2.62e-06	3	33	2	15987792
Pubmed	Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels.	ASIC2 ASIC1	2.62e-06	3	33	2	15470133
Pubmed	The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory.	ASIC2 ASIC1	2.62e-06	3	33	2	11988176
Pubmed	Acid-sensing ion channels contribute to the effect of extracellular acidosis on proliferation and migration of A549 cells.	ASIC2 ASIC1	2.62e-06	3	33	2	28618956
Pubmed	Role of acid-sensing ion channels in hypoxia- and hypercapnia-induced ventilatory responses.	ASIC2 ASIC1	2.62e-06	3	33	2	29474404
Pubmed	Acid-sensing ion channels (ASICs) in mouse skeletal muscle afferents are heteromers composed of ASIC1a, ASIC2, and ASIC3 subunits.	ASIC2 ASIC1	2.62e-06	3	33	2	23109675
Pubmed	ASIC-dependent LTP at multiple glutamatergic synapses in amygdala network is required for fear memory.	ASIC2 ASIC1	2.62e-06	3	33	2	25988357
Pubmed	Lack of plasminogen leads to milk stasis and premature mammary gland involution during lactation.	FGG PLG	2.62e-06	3	33	2	16949567
Pubmed	Localization and comparative analysis of acid-sensing ion channel (ASIC1, 2, and 3) mRNA expression in mouse colonic sensory neurons within thoracolumbar dorsal root ganglia.	ASIC2 ASIC1	2.62e-06	3	33	2	17177258
Pubmed	Up-regulation of acid-sensing ion channels in the capsule of the joint in frozen shoulder.	ASIC2 ASIC1	2.62e-06	3	33	2	26033064
Pubmed	Acid-sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurones.	ASIC2 ASIC1	2.62e-06	3	33	2	14990679
Pubmed	Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity.	ASIC2 ASIC1	2.62e-06	3	33	2	24952644
Pubmed	Acid-sensing ion channels contribute to the effect of acidosis on the function of dendritic cells.	ASIC2 ASIC1	2.62e-06	3	33	2	21321108
Pubmed	Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons.	ASIC2 ASIC1	2.62e-06	3	33	2	11854527
Pubmed	Modulation of Acid-sensing Ion Channel 1a by Intracellular pH and Its Role in Ischemic Stroke.	ASIC2 ASIC1	2.62e-06	3	33	2	27402850
Pubmed	Mice lacking acid-sensing ion channels (ASIC) 1 or 2, but not ASIC3, show increased pain behaviour in the formalin test.	ASIC2 ASIC1	2.62e-06	3	33	2	18801682
Pubmed	Plasmin-driven fibrinolysis facilitates skin tumor growth in a gender-dependent manner.	FGG PLG	2.62e-06	3	33	2	22815383
Pubmed	A kinase-anchoring protein 150 and calcineurin are involved in regulation of acid-sensing ion channels ASIC1a and ASIC2a.	ASIC2 ASIC1	2.62e-06	3	33	2	17548344
Pubmed	ASIC2 subunits target acid-sensing ion channels to the synapse via an association with PSD-95.	ASIC2 ASIC1	2.62e-06	3	33	2	19571134
Pubmed	The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons.	ASIC2 ASIC1	2.62e-06	3	33	2	11739374
Pubmed	Citric Acid in Drug Formulations Causes Pain by Potentiating Acid-Sensing Ion Channel 1.	ASIC2 ASIC1	2.62e-06	3	33	2	33888605
Pubmed	Expression of acid-sensing ion channels of gastric mucosa from patients with Henoch-Schönlein purpura.	ASIC2 ASIC1	2.62e-06	3	33	2	22157923
Pubmed	Acid sensing ion channels regulate neuronal excitability by inhibiting BK potassium channels.	ASIC2 ASIC1	2.62e-06	3	33	2	22960074
Pubmed	Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.	HSPG2 NELL2 LTBP3 EFEMP2	4.77e-06	118	33	4	21078624
Pubmed	Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel).	ASIC2 ASIC1	5.23e-06	4	33	2	11802773
Pubmed	Defining blood-induced microglia functions in neurodegeneration through multiomic profiling.	C3 FGG	5.23e-06	4	33	2	37291385
Pubmed	Expression Profiles of ASIC1/2 and TRPV1/4 in Common Skin Tumors.	ASIC2 ASIC1	5.23e-06	4	33	2	34199609
Pubmed	Fibrin accumulation secondary to loss of plasmin-mediated fibrinolysis drives inflammatory osteoporosis in mice.	FGG PLG	5.23e-06	4	33	2	24664548
Pubmed	Stomatin modulates gating of acid-sensing ion channels.	ASIC2 ASIC1	5.23e-06	4	33	2	15471860
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-7 ERVK-24	5.23e-06	4	33	2	10469592
Pubmed	AlphaMbeta2 (CD11b/CD18, Mac-1) integrin activation by a unique monoclonal antibody to alphaM I domain that is divalent cation-sensitive.	C3 FGG	5.23e-06	4	33	2	11073102
Pubmed	Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.	TINAGL1 HSPG2 FGG PLG	8.14e-06	135	33	4	28675934
Pubmed	Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.	ERVK-5 ERVK-7	8.72e-06	5	33	2	11401426
Pubmed	Extracellular Hsp90α and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1.	HSPG2 C3 PLG	1.00e-05	44	33	3	31273033
Pubmed	Cloning, expression and genetic mapping of the mouse SH3 domain protein, SH3D2B.	C3 VAV1	1.31e-05	6	33	2	9434950
Pubmed	Sour ageusia in two individuals implicates ion channels of the ASIC and PKD families in human sour taste perception at the anterior tongue.	ASIC2 ASIC1	1.31e-05	6	33	2	19812697
Pubmed	Identification and characterization of a seven transmembrane hormone receptor using differential display.	C3 VAV1	1.31e-05	6	33	2	9169125
Pubmed	Plasmin-mediated fibrinolysis enables macrophage migration in a murine model of inflammation.	FGG PLG	1.31e-05	6	33	2	31101623
Pubmed	Profibrinolytic effects of metalloproteinases during skin wound healing in the absence of plasminogen.	FGG PLG	1.31e-05	6	33	2	18337830
Pubmed	Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.	TINAGL1 HSPG2 FGG PLG	1.33e-05	153	33	4	25037231
Pubmed	Human colostrum: identification of minor proteins in the aqueous phase by proteomics.	HSPG2 C3 FGG PLG	1.67e-05	162	33	4	16502470
Pubmed	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.	TINAGL1 HSPG2 FGG PLG	2.26e-05	175	33	4	28071719
Pubmed	Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors.	ASIC2 ASIC1	2.44e-05	8	33	2	27161260
Pubmed	Functional consequence of fibulin-4 missense mutations associated with vascular and skeletal abnormalities and cutis laxa.	LTBP3 EFEMP2	2.44e-05	8	33	2	27339457
Pubmed	Parkinson's disease plasma biomarkers: an automated literature analysis followed by experimental validation.	C3 FGG	3.13e-05	9	33	2	23385359
Pubmed	Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins.	C3 VAV1	3.13e-05	9	33	2	8661125
Pubmed	Functional modifications of acid-sensing ion channels by ligand-gated chloride channels.	ASIC2 ASIC1	3.91e-05	10	33	2	21789198
Pubmed	Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).	TINAGL1 HSPG2 LTBP3 PLG EFEMP2	4.35e-05	417	33	5	19199708
Pubmed	SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix.	HSPG2 PLG	4.78e-05	11	33	2	2745554
Pubmed	Comprehensive proteomic characterization of stem cell-derived extracellular matrices.	HSPG2 FGG EFEMP2	7.55e-05	86	33	3	28327460
Pubmed	Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.	TINAGL1 HSPG2 C3 EFEMP2	8.78e-05	248	33	4	24006456
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-5 ERVK-7 ERVK-24	9.84e-05	94	33	3	21542922
Pubmed	Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.	MUC19 HERC2	1.04e-04	16	33	2	19068216
Pubmed	High-resolution comparative mapping of mouse chromosome 17.	C3 PLG	1.04e-04	16	33	2	8406442
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	TINAGL1 TNFRSF6B ADAM30 TMEM9B EFEMP2 WFIKKN2	2.93e-04	985	33	6	12975309
Pubmed	Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.	C3 FGG PLG	3.39e-04	143	33	3	22516433
Pubmed	Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.	TINAGL1 HSPG2 LTBP3	3.61e-04	146	33	3	27068509
Pubmed	Characterization of molecules binding to the 70K N-terminal region of fibronectin by IFAST purification coupled with mass spectrometry.	C3 FGG	4.25e-04	32	33	2	23750785
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TINAGL1 HSPG2 HEG1 LTBP3 HERC2 MED13	5.39e-04	1105	33	6	35748872
Pubmed	Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.	C3 FGG	6.01e-04	38	33	2	16263699
Pubmed	Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.	TINAGL1 HEG1 TMEM9B EFEMP2	7.10e-04	430	33	4	16303743
Pubmed	Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.	ASIC2 ASIC1	8.06e-04	44	33	2	19322198
Pubmed	Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.	C3 FGG	9.19e-04	47	33	2	14760718
Cytoband	12q12	MUC19 NELL2 ASIC1	5.37e-06	47	33	3	12q12
Cytoband	Ensembl 112 genes in cytogenetic band chr12q12	MUC19 NELL2	9.52e-04	63	33	2	chr12q12
Cytoband	11q13.1	LTBP3 EFEMP2	9.52e-04	63	33	2	11q13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr1q42	COQ8A WNT9A	1.29e-02	240	33	2	chr1q42
GeneFamily	Acid sensing ion channel subunits	ASIC2 ASIC1	1.16e-05	5	20	2	290
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	HSPG2 WFIKKN2	1.35e-02	161	20	2	593
GeneFamily	Endogenous ligands	C3 FGG	2.78e-02	237	20	2	542
Coexpression	NABA_MATRISOME	TINAGL1 MUC19 HSPG2 ADAM30 NELL2 LTBP3 FGG PLG EFEMP2 WFIKKN2 WNT9A	7.19e-09	1008	30	11	MM17056
Coexpression	NABA_MATRISOME	TINAGL1 MUC19 HSPG2 ADAM30 NELL2 LTBP3 FGG PLG EFEMP2 WFIKKN2 WNT9A	8.64e-09	1026	30	11	M5889
Coexpression	NABA_CORE_MATRISOME	TINAGL1 HSPG2 NELL2 LTBP3 FGG EFEMP2	5.45e-07	270	30	6	MM17057
Coexpression	NABA_CORE_MATRISOME	TINAGL1 HSPG2 NELL2 LTBP3 FGG EFEMP2	6.07e-07	275	30	6	M5884
Coexpression	NABA_ECM_GLYCOPROTEINS	TINAGL1 NELL2 LTBP3 FGG EFEMP2	2.40e-06	191	30	5	MM17059
Coexpression	NABA_ECM_GLYCOPROTEINS	TINAGL1 NELL2 LTBP3 FGG EFEMP2	2.72e-06	196	30	5	M3008
Coexpression	NABA_MATRISOME_HIGHLY_METASTATIC_BREAST_CANCER_TUMOR_CELL_DERIVED	TINAGL1 LTBP3 EFEMP2	4.85e-06	29	30	3	M47987
Coexpression	NABA_MATRISOME_HIGHLY_METASTATIC_BREAST_CANCER	TINAGL1 LTBP3 EFEMP2	1.40e-05	41	30	3	M47988
Coexpression	DAUER_STAT3_TARGETS_UP	C3 HEG1 FGG	2.26e-05	48	30	3	M12391
Coexpression	GSE10273_HIGH_VS_LOW_IL7_TREATED_IRF4_8_NULL_PRE_BCELL_DN	TMEM63B SETX HERC2 VAV1	7.57e-05	199	30	4	M316
Coexpression	HEBERT_MATRISOME_TNBC_BONE_BRAIN_LIVER_LUNG_METASTASTASES	TINAGL1 HSPG2	9.80e-05	13	30	2	M48004
Coexpression	HEBERT_MATRISOME_TNBC_LIVER_METASTASIS	FGG PLG	1.14e-04	14	30	2	M48002
Coexpression	AIZARANI_LIVER_C17_HEPATOCYTES_3	C3 FGG PLG	2.15e-04	102	30	3	M39119
ToppCell	droplet-Liver-Hepatocytes-18m-Epithelial-Hepatocyte_(Pericentral,_Midlobular,_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3 FGG PLG COQ8A	3.93e-06	160	30	4	8de1fc75241d9bf2b355afa0e9ef39fea1977177
ToppCell	droplet-Liver-Hepatocytes-18m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3 FGG PLG COQ8A	4.03e-06	161	30	4	274838cebdc7af1db32d309dfe42ef7ccd3c190b
ToppCell	droplet-Liver-Hepatocytes\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3 FGG PLG COQ8A	4.23e-06	163	30	4	a794540f2d8984f963c08f05175e4bc916fcc224
ToppCell	droplet-Liver-Hepatocytes-18m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3 FGG PLG COQ8A	4.23e-06	163	30	4	03d9fa615d9d02ef98e20f28a10aaa6894dd4960
ToppCell	droplet-Liver-Hepatocytes-18m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3 FGG PLG COQ8A	4.23e-06	163	30	4	7e82c1b7849eca895732df2da74ac6430bd9ba7a
ToppCell	droplet-Liver-Hepatocytes-18m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3 FGG PLG COQ8A	4.23e-06	163	30	4	1c4de36cf8cdaabb981cda5c7ce7e5ae7b4280e3
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	C3 ASIC1 WNT9A PLCE1	5.99e-06	178	30	4	c413861148129be1ee94f2ceb5999840217eebe5
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	C3 ASIC1 WNT9A PLCE1	5.99e-06	178	30	4	bcbdd45a2307f8aea14122fa0144b96b1f6eec48
ToppCell	Endothelial-Endothelial-E\|Endothelial / shred on cell class and cell subclass (v4)	HSPG2 HEG1 LTBP3 FBLIM1	7.43e-06	188	30	4	2777eb7689b271c199021fe7d9db88ccebff14de
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-AEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TINAGL1 HSPG2 HEG1 FBLIM1	7.91e-06	191	30	4	50601ef0a5a8f2c2120922989e08e85bf2d9b4ab
ToppCell	343B-Endothelial_cells-Endothelial-B_(Artery)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	TINAGL1 HSPG2 HEG1 FBLIM1	7.91e-06	191	30	4	1dfcff08e01e6a695953334342bcfde04ba005ad
ToppCell	343B-Endothelial_cells-Endothelial-B_(Artery)\|343B / Donor, Lineage, Cell class and subclass (all cells)	TINAGL1 HSPG2 HEG1 FBLIM1	7.91e-06	191	30	4	27a532a35d9e8822014f581fd56c4ca62e39f8fe
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	C3 FBLIM1 ASIC1 EFEMP2	8.08e-06	192	30	4	41a8326cd5bc19ad5041068501bab4c72399222e
ToppCell	facs-Lung-nan-3m-Mesenchymal-Adventitial_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 C3 LTBP3 WNT9A	8.08e-06	192	30	4	a2c31390da4962bda9a936470b0b68fa1f5d47d1
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	C3 FBLIM1 ASIC1 EFEMP2	8.08e-06	192	30	4	f88aba74d6e8c594c32fe2bc095b5da28b4b28e9
ToppCell	AT1_cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	HSPG2 HEG1 WNT9A PLCE1	8.08e-06	192	30	4	0444f9e9cef7403e220e862b5a787443d3f5c9ac
ToppCell	facs-Lung-nan-3m-Mesenchymal-adventitial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 C3 LTBP3 WNT9A	8.08e-06	192	30	4	eeab1cef7c36ae824381952c5b2c982368c379fd
ToppCell	droplet-Limb_Muscle-nan-18m-Mesenchymal\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 C3 LTBP3 EFEMP2	8.24e-06	193	30	4	49600db68ed65cafc67bd45a285b364e4f5f88af
ToppCell	droplet-Limb_Muscle-nan-18m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 C3 LTBP3 EFEMP2	8.24e-06	193	30	4	45b5cab4dfeb0ed3b13631db5963740a792b810f
ToppCell	IPF-Stromal-Pericyte\|World / Disease state, Lineage and Cell class	TINAGL1 FBLIM1 EFEMP2 PLCE1	8.41e-06	194	30	4	1a41da29d5adaf766a84eff0003b959e4523f7f1
ToppCell	(6)_Endothelial-B_(Artery)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	TINAGL1 HSPG2 HEG1 FBLIM1	8.41e-06	194	30	4	0cf4e67d4024652794b5bfdd4a71a7d98900b4c8
ToppCell	facs-Lung-nan\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 C3 LTBP3 PLCE1	8.76e-06	196	30	4	b05f77f3990b662682ffeaf0e4c2fb190e0a6e65
ToppCell	facs-Lung-nan-3m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 C3 LTBP3 PLCE1	8.76e-06	196	30	4	787c6cd92035e0b1108c2c086c42a229016e476b
ToppCell	cellseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-AEC\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TINAGL1 HSPG2 HEG1 FBLIM1	8.94e-06	197	30	4	56afed433887cb2766eb30f22aec195148db33ab
ToppCell	normal_Lung-Endothelial_cells-Stalk-like_ECs\|normal_Lung / Location, Cell class and cell subclass	TINAGL1 HSPG2 HEG1 FBLIM1	9.12e-06	198	30	4	2a251d13c2488d15ca9b11e643c1d17d428b6ef0
ToppCell	facs-Trachea-nan-3m-Mesenchymal-fibroblast\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 C3 HEG1 LTBP3	9.12e-06	198	30	4	0dc7d59a07428a7b7e8bdc81f0e2417dd4ce3cf2
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TINAGL1 HSPG2 HEG1 FBLIM1	9.30e-06	199	30	4	6e3a226ebba023e3e909d7a7188137da4f1fd7fc
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TINAGL1 HSPG2 HEG1 FBLIM1	9.30e-06	199	30	4	6a2943a23fdd2ec814662db7c21a0d6804a6cbbc
ToppCell	distal-2-Endothelial-Artery\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TINAGL1 HSPG2 HEG1 FBLIM1	9.30e-06	199	30	4	fa8aaf7a90699e41a7a4cee5614f8c9248110327
ToppCell	distal-Endothelial-Artery\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TINAGL1 HSPG2 HEG1 FBLIM1	9.30e-06	199	30	4	b6e9aaac047d4b64b9d97f5e174e89a424d8b36d
ToppCell	distal-Endothelial-Artery-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TINAGL1 HSPG2 HEG1 FBLIM1	9.30e-06	199	30	4	3788f3218356aaaa10684e48d63757037f8a3a3c
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TINAGL1 HSPG2 HEG1 FBLIM1	9.49e-06	200	30	4	ac6b8bc9998d303f788511b8f111e682ea9f3df8
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TINAGL1 TNFRSF6B HSPG2 HEG1	9.49e-06	200	30	4	86ec951234015ced7126b016199e5869a0f22478
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TINAGL1 HSPG2 HEG1 FBLIM1	9.49e-06	200	30	4	ecb6d3f7181a0f3c6bf197fc69bed0696d711199
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TINAGL1 HSPG2 HEG1 FBLIM1	9.49e-06	200	30	4	7547d6339f9380d031cfd2cce21ac9a12491e085
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TINAGL1 TNFRSF6B HSPG2 HEG1	9.49e-06	200	30	4	c239e6f5d23caa9a59b83e9b352b2d6a691dcb28
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	TNFRSF6B NUB1 HEG1 SETX	9.49e-06	200	30	4	89821a264e872ed53e08e9d3609d5cc5c314503e
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	TNFRSF6B NUB1 HEG1 SETX	9.49e-06	200	30	4	79e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCell	Thalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a7-Tac2-Excitatory_Neuron.Slc17a7.Tac2.Syt15_(Medial_habenula)\|Thalamus / BrainAtlas - Mouse McCarroll V32	KCNG3 WFIKKN2 EDDM13	1.89e-05	77	30	3	7f624e9262bd0dc2ac4176f43c91a4bc0f521fe5
ToppCell	facs-Thymus-nan-3m-Epithelial-epithelial_cell_of_thymus\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAM30 PLG EDDM13	1.13e-04	140	30	3	115bd770a9d5e6f007a9aa0eadf5dba46d500107
ToppCell	facs-Thymus-nan-3m-Epithelial\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAM30 PLG EDDM13	1.13e-04	140	30	3	22d126e80bf7d9c0ca6ec686b5cc66fa584a1ab6
ToppCell	facs-Thymus-nan-3m-Epithelial-TECs\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAM30 PLG EDDM13	1.13e-04	140	30	3	62d1ef8cb78618ed89cac7ec89d7f54de06a90c7
ToppCell	droplet-Liver-hepatocytes-3m-Epithelial-Hepatocyte_(Pericentral_and_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGG PLG COQ8A	1.30e-04	147	30	3	00619115b9a1ec2b967c2992043b41974ece63c4
ToppCell	facs-Liver-Non-hepatocytes-24m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3 FGG PLG	1.33e-04	148	30	3	763c598826445bf627989220cd7acd71c4f1ea36
ToppCell	facs-Liver-Non-hepatocytes-24m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3 FGG PLG	1.33e-04	148	30	3	d3f224128593251b72429a1cd52e82f77df8e386
ToppCell	facs-Liver-Non-hepatocytes-24m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3 FGG PLG	1.33e-04	148	30	3	5c853637f6058f78608ba0e76cda72a548d40710
ToppCell	droplet-Liver-nan-3m-Epithelial-Hepatocyte_(Pericentral,_Midlobular,_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGG PLG COQ8A	1.41e-04	151	30	3	cc9632b58522e2ba3ad36a0b8d37c7c9c8b636c4
ToppCell	droplet-Liver-nan-3m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGG PLG COQ8A	1.41e-04	151	30	3	7758cfbe8dca849c90bd6e8bc63310e53beeb8fd
ToppCell	droplet-Liver-nan-3m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGG PLG COQ8A	1.41e-04	151	30	3	b4a0546c1573b4b2290890307f2a5daf3a7cbb37
ToppCell	droplet-Liver-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGG PLG COQ8A	1.44e-04	152	30	3	1febeeb7376e34b9f86c81b2cb1314ee12408864
ToppCell	droplet-Liver-nan-3m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGG PLG COQ8A	1.44e-04	152	30	3	faa92f7c5a6db9f1eb7d8ec930ba7c8ed9fd1bf1
ToppCell	droplet-Liver-Hepatocytes-24m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3 FGG PLG	1.44e-04	152	30	3	c21e2152b0130485659051d8fb7fb4589d1ec997
ToppCell	PND07-28-samps-Mesenchymal-Mesothelial-Mesothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	ASIC1 WNT9A PLCE1	1.55e-04	156	30	3	605d95a900e1443d3f6aae163ef2e893d3293203
ToppCell	PND07-28-samps-Mesenchymal-Mesothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	ASIC1 WNT9A PLCE1	1.55e-04	156	30	3	574f761962a7dd3308bd41fc529dd3ea1b8625f8
ToppCell	droplet-Liver-nan-3m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3 FGG PLG	1.58e-04	157	30	3	b72c6a1ed17bfc32d9dec193d934ea82e80b6bd5
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3 FGG PLG	1.61e-04	158	30	3	9f58428f70d1427b20122c5c1cc7bf521d0f4832
ToppCell	facs-Liver\|facs / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3 FGG PLG	1.61e-04	158	30	3	ea7db6bd9742153ceb6e444892a6d1df9c7fcc96
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Type_1_alveolar\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	HSPG2 HEG1 ASIC1	1.67e-04	160	30	3	58ed3a074932ccc951e07868dfdc61b99ae1cc2b
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TINAGL1 HSPG2 HEG1	1.86e-04	166	30	3	f7926ee266dcbf10df375cd921f1db5a2fa604f8
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TINAGL1 HEG1 FBLIM1	1.89e-04	167	30	3	f01b96173deda0239fa482989873cf308e49d48c
ToppCell	mild_COVID-19_(asymptomatic)-CD4+_T_naive\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	NELL2 MAP3K15 LTBP3	1.89e-04	167	30	3	78d264af390bd89942ffbb2991dc94f50756d4c9
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	C3 ASIC1 PLCE1	1.89e-04	167	30	3	d50311b1f66f143bae4c4cf50e2e9b13c85d6920
ToppCell	facs-Skin-Anagen-24m-Epithelial-bulge_keratinocyte\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MUC19 HSPG2 LTBP3	1.89e-04	167	30	3	78909f685ccd1321064eb0887caf9263e0e54879
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TINAGL1 HEG1 FBLIM1	1.89e-04	167	30	3	5fc85a05124cd2324e1b8ff940193880f83cd8af
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	C3 ASIC1 PLCE1	1.89e-04	167	30	3	7abc785e688a384672d7fb5a62d32538fe7e5a51
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L6_LHX6_GLP1R\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TINAGL1 FRMD8P1 PLCE1	1.93e-04	168	30	3	2eed7dc1a2aff11be024823c4323c42bc94362f6
ToppCell	Posterior_cortex-Endothelial-MURAL\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	TINAGL1 FBLIM1 PLCE1	1.96e-04	169	30	3	0ae65daf092396b71f790b65c7a2feed90397417
ToppCell	Posterior_cortex-Endothelial-MURAL-M1(Rgs5Acta2)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	TINAGL1 FBLIM1 PLCE1	1.96e-04	169	30	3	8cd70ce27b1cecb83f8a376230e7ef41b079b124
ToppCell	droplet-Pancreas-Exocrine-18m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TINAGL1 HSPG2 C3	1.96e-04	169	30	3	53690d6f9712b54aa99a0408aae930d64ae478e5
ToppCell	5'-Adult-LargeIntestine-Epithelial-neuro-epithelial-EECs\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCNG3 WNT9A EDDM13	2.03e-04	171	30	3	dd37e1693a5cfc42e40992d504f92048a8038b52
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MUC19 HSPG2 HEG1	2.07e-04	172	30	3	de9b11ab109d04937186c09772cec9105a935f95
ToppCell	droplet-Liver\|droplet / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C3 FGG PLG	2.07e-04	172	30	3	cd0e8f48836a16026b47ade06abadf26b53f581f
ToppCell	P07-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	C3 ASIC1 PLCE1	2.07e-04	172	30	3	9a256db817c1af1802203cc88a55d608fb328c63
ToppCell	Club-club-3\|World / Class top	ADAM30 C3 WFIKKN2	2.07e-04	172	30	3	34fbb82a2ec77dd183cf26b38edeb7e936b707bc
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	C3 NELL2 PLCE1	2.10e-04	173	30	3	3725525b99a6011eda2ff5459b4fd2e1eab1f090
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	C3 NELL2 PLCE1	2.10e-04	173	30	3	ee7d1429f23f1b89a9a9f7bc07a84a44cf7acd1c
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-arterial_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	MUC19 HSPG2 HEG1	2.10e-04	173	30	3	3a9e9a09b3eeb37cbe56d650e112a8398879477f
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TINAGL1 HSPG2 FBLIM1	2.14e-04	174	30	3	9f2e253694eb5860c00528fda31c305c6de8a2a1
ToppCell	Adult-Endothelial-endothelial_cell_of_vein-D231\|Adult / Lineage, Cell type, age group and donor	TINAGL1 HSPG2 HEG1	2.14e-04	174	30	3	2dd647c4fdf99fd1f7b838efef01baf2cbc3446d
ToppCell	COVID-19-kidney-PCT-S3-2\|kidney / Disease (COVID-19 only), tissue and cell type	C3 FGG PLG	2.14e-04	174	30	3	5aa2fb631505600f37d2b87b02def7be139dc262
ToppCell	tumor_Lung-Endothelial_cells-EPCs\|tumor_Lung / Location, Cell class and cell subclass	TINAGL1 HSPG2 HEG1	2.25e-04	177	30	3	f8b152c09d56a97e8c0482fb1a3964c05f9dc8c5
ToppCell	5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-Mature_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TINAGL1 TNFRSF6B HSPG2	2.29e-04	178	30	3	aa44851653d276226b922ee14dd1fc8d1a844cdf
ToppCell	390C-Epithelial_cells-Epithelial-B_(AT2)\|390C / Donor, Lineage, Cell class and subclass (all cells)	TMEM63B C3 FGG	2.32e-04	179	30	3	466da2bc3bfc534ffe111c8c28ece7a3cfa08051
ToppCell	390C-Epithelial_cells-Epithelial-B_(AT2)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	TMEM63B C3 FGG	2.32e-04	179	30	3	f4bdebb77d39e63160fbf3a85a340ce4d52b7cfd
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-OMD+_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	HSPG2 HEG1 LTBP3	2.32e-04	179	30	3	8c9ed247e1c4d655b81ce2f24a9936a7cade718a
ToppCell	Endothelial-A-Donor_05\|World / lung cells shred on cell class, cell subclass, sample id	TINAGL1 HSPG2 HEG1	2.32e-04	179	30	3	138fd6ba6bdbd0ad01c574168addf720b67a0fea
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	C3 ASIC1 WNT9A	2.32e-04	179	30	3	adf8b025032a03dbb58871a92025cd7efbeb22ff
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TINAGL1 FBLIM1 EFEMP2	2.32e-04	179	30	3	b70509288aaf4457afd350f6c45784521337ce0d
ToppCell	P03-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	C3 ASIC1 PLCE1	2.36e-04	180	30	3	2ccc77d769d3ffd77ab3af45e4f192785b6db79c
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_vein-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TINAGL1 HSPG2 HEG1	2.36e-04	180	30	3	27e8bbee388e64dd79d70b160b76d45b1f398006
ToppCell	5'-Adult-LymphNode-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	C3 ASIC1 WNT9A	2.40e-04	181	30	3	ab66a89f316b935d9ba1277426d976b1e9e39757
ToppCell	10x3'2.3-week_12-13-Mesenchymal_myocytic\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	FBLIM1 ASIC1 EFEMP2	2.40e-04	181	30	3	47dce04db3392333eb2f7b9b24c32e6740d2d02f
ToppCell	droplet-Liver-nan-3m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TINAGL1 HSPG2 SETX	2.40e-04	181	30	3	fcc94f04dae98b817ec06b282d2e887804d37ae5
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TINAGL1 HSPG2 HEG1	2.40e-04	181	30	3	2c660fcf0404c155955b67ab2958d6e6b0e30024
ToppCell	10x3'2.3-week_12-13-Mesenchymal_myocytic-stroma\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	FBLIM1 ASIC1 EFEMP2	2.40e-04	181	30	3	19103221c3a5a16b16378348004b2c50caee4f01
ToppCell	ASK454-Epithelial\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	TINAGL1 LTBP3 PLCE1	2.44e-04	182	30	3	ab15316cff989b61ff397a866d7ca8b49c13e981
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TINAGL1 FBLIM1 PLCE1	2.44e-04	182	30	3	a3c5c0eff527c8d3848acda14af8f9e99c69b0de
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 HEG1 ASIC2	2.52e-04	184	30	3	688428103e8b19f45f2f65d70a0f30c904c8411c
ToppCell	wk_20-22-Epithelial-PNS-intermediate_Schwann\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	HSPG2 NELL2 MED13	2.52e-04	184	30	3	4e3ba64692868563a579902aa9c6f88cab5bce26
ToppCell	Endothelial-A-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	TINAGL1 HSPG2 HEG1	2.56e-04	185	30	3	ae49c61f6ecf128fe2a958b8c75c83688da75f59
Computational	Blood coagulation factors.	FGG PLG EFEMP2	2.47e-05	33	19	3	MODULE_131
Drug	nafamostat mesilate	C3 FGG PLG ASIC2 ASIC1	4.32e-08	77	29	5	CID000004413
Drug	6-amidino-2-naphthol	ASIC2 ASIC1	2.34e-05	6	29	2	CID005490350
Drug	Gly-his-arg	FGG PLG	3.28e-05	7	29	2	CID000133872
Drug	1-bromo-2-chloroethane	C3 HEG1	4.37e-05	8	29	2	CID000007849
Drug	Desaa-fibrin	FGG PLG	4.37e-05	8	29	2	CID000127263
Drug	pyrachlostrobin	TINAGL1 HSPG2 C3 HEG1 LTBP3 EFEMP2 PLCE1	5.57e-05	811	29	7	ctd:C513428
Drug	Amiloride	ASIC2 ASIC1	5.61e-05	9	29	2	DB00594
Drug	Fibrin	FGG PLG	5.61e-05	9	29	2	CID000439199
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A	TNFRSF6B HEG1 EFEMP2 PLCE1	9.87e-05	192	29	4	3332_UP
Drug	Idoxuridine [54-42-2]; Up 200; 11.2uM; MCF7; HT_HG-U133A	TNFRSF6B C3 HEG1 EFEMP2	1.01e-04	193	29	4	1480_UP
Drug	Rgh 2958	FGG PLG	1.03e-04	12	29	2	CID000124710
Drug	Ganciclovir [82410-32-0]; Up 200; 15.6uM; MCF7; HT_HG-U133A	HSPG2 HEG1 ASIC2 PLCE1	1.07e-04	196	29	4	3368_UP
Drug	Pivampicillin [33817-20-8]; Up 200; 8.6uM; MCF7; HT_HG-U133A	ADAM30 C3 HEG1 ASIC2	1.07e-04	196	29	4	3506_UP
Drug	Tomatidine [77-59-8]; Up 200; 9.6uM; MCF7; HT_HG-U133A	TNFRSF6B C3 NELL2 EFEMP2	1.09e-04	197	29	4	2746_UP
Drug	Clofilium tosylate [92953-10-1]; Up 200; 7.8uM; MCF7; HT_HG-U133A	TNFRSF6B HSPG2 PLG EFEMP2	1.09e-04	197	29	4	6830_UP
Drug	Dichlorphenamide [120-97-8]; Up 200; 13.2uM; HL60; HT_HG-U133A	TINAGL1 HEG1 EFEMP2 PLCE1	1.11e-04	198	29	4	3027_UP
Drug	Sulfamerazine [127-79-7]; Up 200; 15.2uM; MCF7; HT_HG-U133A	NELL2 PLG EFEMP2 PLCE1	1.11e-04	198	29	4	6036_UP
Drug	LY 294002; Up 200; 0.1uM; MCF7; HT_HG-U133A	TNFRSF6B HSPG2 C3 ASIC1	1.11e-04	198	29	4	5213_UP
Drug	Amiloride	PLG ASIC2 ASIC1	1.33e-04	78	29	3	ctd:D000584
Drug	Rgdf peptide	FGG PLG	1.41e-04	14	29	2	CID003080994
Drug	NSC-270916	C3 FGG PLG	1.54e-04	82	29	3	CID000002949
Drug	S 2441	FGG PLG	1.63e-04	15	29	2	CID000133194
Drug	diethylene glycol	HEG1 ASIC2 ASIC1	1.65e-04	84	29	3	CID000008117
Drug	Gly-his-arg-pro	FGG PLG	1.86e-04	16	29	2	CID000128928
Drug	metaphit	C3 ASIC1	1.86e-04	16	29	2	CID000114745
Disease	COVID-19 (is_implicated_in)	C3 PLG	1.80e-04	21	28	2	DOID:0080600 (is_implicated_in)
Disease	serum gamma-glutamyl transferase measurement	TNFRSF6B ADAM30 C3 FBLIM1 MED13 PLCE1	1.83e-04	914	28	6	EFO_0004532
Disease	arginine measurement	TINAGL1 ASIC2	2.17e-04	23	28	2	EFO_0020990
Disease	cataract	HERC2 COQ8A PLCE1	3.21e-04	141	28	3	MONDO_0005129
Disease	glaucoma	LTBP3 HERC2 PLCE1	4.15e-04	154	28	3	MONDO_0005041
Disease	folic acid measurement	ASIC2 WNT9A	8.76e-04	46	28	2	EFO_0005111
Disease	optic cup area measurement	LTBP3 PLCE1	1.30e-03	56	28	2	EFO_0006940
Disease	retinal vasculature measurement	HSPG2 LTBP3 HERC2 PLCE1	1.37e-03	517	28	4	EFO_0010554

Protein segments in the cluster

Peptide	Gene	Start	Entry
CRDELCRCAEENCFI	C3	1506	P01024
DCEPRQLRADDCFCA	BTBD11	541	A6QL63
ACRIDCETRYIVENC	ASIC2	306	Q16515
ECVALEYRCDRRPDC	HSPG2	211	P98160
CRSERDVLEVCDDYD	KCNG3	41	Q8TAE7
DADKYFCECCRELLD	NUB1	261	Q9Y5A7
FCECCRELLDTVDNY	NUB1	266	Q9Y5A7
LREDNAYCEDIDECA	NELL2	431	Q99435
MVRCCRAYEEVCEGD	HERC2	2576	O95714
VLAARYLCDVEDCEA	FRMD8P1	156	Q9BZ68
LLEHSCLCCREENYE	MUC19	8331	Q7Z5P9
CLCCREENYELRDIV	MUC19	8336	Q7Z5P9
CRACEDGYRLENETC	HEG1	1216	Q9ULI3
KQERSDCYCVCVERS	ERVK-5	51	P61583
KQERSDCYCVCVERS	ERVK-7	51	P61582
KQERSDCYCVCVERS	ERVK-24	51	P61581
AYVATRDNCCILDER	FGG	26	P02679
VCRQEGNECDLAEYC	ADAM30	456	Q9UKF2
CCVVRGCEQVEAIEY	TMEM63B	321	Q5T3F8
ELALECDYQREAACA	COQ8A	401	Q8NI60
YCNLELDIRDDPCCS	EDDM13	146	A0A1B0GTR0
HRYCVDVNECEAEPC	LTBP3	611	Q9NS15
NCYRCEDCRILLSVE	FBLIM1	331	Q8WUP2
ECVDIDECRYRYCQH	EFEMP2	161	O95967
CADYFCCESDAQRRA	MAP3K15	191	Q6ZN16
RYCQEQDLCCRGRAD	TINAGL1	46	Q9GZM7
CLKQCVRDTVCEYRA	PLCE1	441	Q9P212
QTADEDLCYCLECVA	SETX	31	Q7Z333
VRVEERDCCNDCYLA	MED13	1221	Q9UHV7
KRYDYCDILECEEEC	PLG	171	P00747
RIDCETRYLVENCNC	ASIC1	311	P78348
EDYRTRVCDCVLKAC	STK19	216	P49842
DVEAYCLRCECKYEE	TMEM9B	81	Q9NQ34
EYDKRCCCLREIQQT	VAV1	191	P15498
CCYVECRQCTQREEV	WNT9A	346	O14904
ERCRYCNVLCGEREE	TNFRSF6B	86	O95407
TCRRECETDQECETY	WFIKKN2	61	Q8TEU8