Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionN-acetyllactosamine synthase activity

B4GALT4 B4GALT3

6.36e-055512GO:0003945
GeneOntologyBiologicalProcessmitotic actomyosin contractile ring assembly

IQGAP2 IQGAP3

2.17e-053562GO:1903475
GeneOntologyBiologicalProcessmitotic actomyosin contractile ring assembly actin filament organization

IQGAP2 IQGAP3

2.17e-053562GO:1903479
GeneOntologyBiologicalProcessassembly of actomyosin apparatus involved in mitotic cytokinesis

IQGAP2 IQGAP3

2.17e-053562GO:1902407
GeneOntologyBiologicalProcessactomyosin contractile ring assembly actin filament organization

IQGAP2 IQGAP3

4.33e-054562GO:2000689
GeneOntologyBiologicalProcessregulation of synapse organization

ROCK2 SLITRK2 MYCBP2 UBE3A SLITRK4 DGKB UBE2M

8.15e-05387567GO:0050807
GeneOntologyBiologicalProcessregulation of synapse structure or activity

ROCK2 SLITRK2 MYCBP2 UBE3A SLITRK4 DGKB UBE2M

9.26e-05395567GO:0050803
GeneOntologyBiologicalProcesscortical actin cytoskeleton organization

ROCK2 IQGAP2 IQGAP3

2.48e-0445563GO:0030866
GeneOntologyBiologicalProcessactomyosin contractile ring assembly

IQGAP2 IQGAP3

2.57e-049562GO:0000915
GeneOntologyBiologicalProcessassembly of actomyosin apparatus involved in cytokinesis

IQGAP2 IQGAP3

2.57e-049562GO:0000912
DomainRasGAP_C

IQGAP2 IQGAP3

2.19e-053512IPR000593
DomainRasGAP_C

IQGAP2 IQGAP3

2.19e-053512PF03836
DomainLRRNT

SLITRK2 SLITRK4 LRRC70 OMD

1.47e-0498514IPR000372
DomainLRRNT

SLITRK2 SLITRK4 LRRC70 OMD

1.47e-0498514SM00013
DomainGalactosyl_T

B4GALT4 B4GALT3

1.52e-047512IPR003859
DomainGlyco_transf_7C

B4GALT4 B4GALT3

1.52e-047512PF02709
DomainGlyco_transf_7N

B4GALT4 B4GALT3

1.52e-047512PF13733
DomainGalactosyl_T_C

B4GALT4 B4GALT3

1.52e-047512IPR027791
DomainGalactosyl_T_N

B4GALT4 B4GALT3

1.52e-047512IPR027995
DomainLRR

SLITRK2 SLITRK4 LRRC72 LRRC70 OMD

2.16e-04201515PS51450
DomainLRRNT

SLITRK2 SLITRK4 OMD

4.08e-0453513PF01462
DomainRasGAP

IQGAP2 IQGAP3

6.51e-0414512SM00323
DomainRasGAP_CS

IQGAP2 IQGAP3

6.51e-0414512IPR023152
DomainRasGAP

IQGAP2 IQGAP3

7.50e-0415512PF00616
DomainRAS_GTPASE_ACTIV_1

IQGAP2 IQGAP3

7.50e-0415512PS00509
DomainRAS_GTPASE_ACTIV_2

IQGAP2 IQGAP3

7.50e-0415512PS50018
DomainLeu-rich_rpt

SLITRK2 SLITRK4 LRRC72 LRRC70 OMD

8.44e-04271515IPR001611
Domain-

IQGAP2 IQGAP3

8.56e-04165121.10.506.10
DomainRasGAP_dom

IQGAP2 IQGAP3

1.09e-0318512IPR001936
DomainLRR_8

SLITRK2 SLITRK4 LRRC70 OMD

1.21e-03171514PF13855
DomainLeu-rich_rpt_typical-subtyp

SLITRK2 SLITRK4 LRRC70 OMD

1.38e-03177514IPR003591
DomainLRR_TYP

SLITRK2 SLITRK4 LRRC70 OMD

1.38e-03177514SM00369
DomainQuino_amine_DH_bsu

WDR36 WDR6

1.63e-0322512IPR011044
Domain-

SLITRK2 SLITRK4 LRRC72 LRRC70 OMD

1.79e-033215153.80.10.10
DomainCys-rich_flank_reg_C

SLITRK2 SLITRK4 LRRC70

1.91e-0390513IPR000483
DomainLRRCT

SLITRK2 SLITRK4 LRRC70

1.91e-0390513SM00082
DomainL_dom-like

SLITRK2 SLITRK4 LRRC72 LRRC70 OMD

1.96e-03328515IPR032675
DomainLRR_1

SLITRK2 SLITRK4 LRRC70 OMD

2.99e-03219514PF00560
DomainLAM_G_DOMAIN

FAT1 USH2A

4.83e-0338512PS50025
DomainLaminin_G_2

FAT1 USH2A

5.34e-0340512PF02210
DomainLamG

FAT1 USH2A

6.43e-0344512SM00282
PathwayREACTOME_KERATAN_SULFATE_BIOSYNTHESIS

OMD B4GALT4 B4GALT3

6.11e-0528393M670
PathwayREACTOME_KERATAN_SULFATE_BIOSYNTHESIS

OMD B4GALT4 B4GALT3

6.11e-0528393MM14798
PathwayREACTOME_KERATAN_SULFATE_KERATIN_METABOLISM

OMD B4GALT4 B4GALT3

1.31e-0436393M690
PathwayREACTOME_KERATAN_SULFATE_KERATIN_METABOLISM

OMD B4GALT4 B4GALT3

1.31e-0436393MM14632
PathwayKEGG_MEDICUS_REFERENCE_BLOOD_GROUP_H_O_ANTIGEN_TYPE_2_BIOSYNTHESIS

B4GALT4 B4GALT3

1.55e-047392M47965
PathwayKEGG_MEDICUS_REFERENCE_II_BLOOD_GROUP_ANTIGEN_BIOSYNTHESIS

B4GALT4 B4GALT3

1.55e-047392M47968
PathwayWP_NEOLACTO_SERIES_SPHINGOLIPID_METABOLISM

B4GALT4 B4GALT3

4.04e-0411392M48314
PathwayKEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE

B4GALT4 B4GALT3

7.65e-0415392M3042
PathwayREACTOME_N_GLYCAN_ANTENNAE_ELONGATION

B4GALT4 B4GALT3

7.65e-0415392M966
PathwayREACTOME_N_GLYCAN_ANTENNAE_ELONGATION

B4GALT4 B4GALT3

7.65e-0415392MM15700
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

XRN2 WDR36 POLR1A MYCBP2 WDR6 UBR4 EIF3E CCT2 MSH2 ECPAS TP53BP1

6.51e-09653561122586326
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

KIFBP XRN2 POLR1A IQGAP2 UBE3A UBR4 UBE2M MSH2 IQGAP3 TP53BP1

1.67e-07704561029955894
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

USP36 XRN2 WDR36 POLR1A MYCBP2 UBE3A WDR6 UBR4 EIF3E CCT2 UBE2M MSH2 TP53BP1

1.75e-071353561329467282
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

USP36 KIFBP XRN2 WDR36 POLR1A WDR6 UBR4 EIF3E CCT2 UBE2M MSH2 ECPAS IQGAP3

3.17e-071425561330948266
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

XRN2 POLR1A IQGAP2 MYCBP2 UBE3A WDR6 UBR4 EIF3E CCT2 MSH2 PIPSL IQGAP3

6.05e-071257561237317656
Pubmed

FAT1 and MSH2 Are Predictive Prognostic Markers for Chinese Osteosarcoma Patients Following Chemotherapeutic Treatment.

FAT1 MSH2

2.55e-06256235279875
Pubmed

Reduced expression of IQGAP2 and higher expression of IQGAP3 correlates with poor prognosis in cancers.

IQGAP2 IQGAP3

2.55e-06256229073199
Pubmed

Beta-1,4-galactosyltransferase-3 deficiency suppresses the growth of immunogenic tumors in mice.

B4GALT4 B4GALT3

2.55e-06256237901252
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

XRN2 WDR36 POLR1A UBE3A UBR4 RNF213 CCT2 UBE2M MSH2 ECPAS

4.48e-061014561032416067
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

XRN2 MYCBP2 UBR4 EIF3E ZFHX3 CCT2 UBE2M ECPAS IQGAP3

5.33e-0680756930575818
Pubmed

The biology of IQGAP proteins: beyond the cytoskeleton.

IQGAP2 IQGAP3

7.63e-06356225722290
Pubmed

Structure of Slitrk2-PTPδ complex reveals mechanisms for splicing-dependent trans-synaptic adhesion.

SLITRK2 SLITRK4

7.63e-06356225989451
Pubmed

IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold.

IQGAP2 IQGAP3

7.63e-06356222493426
Pubmed

Involvement of IQGAP family proteins in the regulation of mammalian cell cytokinesis.

IQGAP2 IQGAP3

7.63e-06356225229330
Pubmed

Galactosylation of N-linked oligosaccharides by human beta-1,4-galactosyltransferases I, II, III, IV, V, and VI expressed in Sf-9 cells.

B4GALT4 B4GALT3

7.63e-06356211588157
Pubmed

Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice.

ROCK2 IRF4

7.63e-06356220697158
Pubmed

Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes.

MYCBP2 UBE3A MSH2 TP53BP1

1.11e-058556416051665
Pubmed

Valosin-containing protein (VCP) is a novel IQ motif-containing GTPase activating protein 1 (IQGAP1)-interacting protein.

IQGAP2 IQGAP3

1.52e-05456228970065
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

KIFBP XRN2 WDR36 IQGAP2 WDR6 UBR4 EIF3E RNF213 CCT2 MSH2 ECPAS

1.58e-051440561130833792
Pubmed

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

MYCBP2 UBE3A UBR4 RNF213

1.72e-059556429643511
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

UBE3A UBR4 RNF213 MSH2 ECPAS TP53BP1

1.83e-0534156632971831
Pubmed

The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.

TRPM4 MYCBP2 UBE3A UBR4 PIPSL

2.38e-0521256533853758
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

XRN2 WDR36 POLR1A IQGAP2 MYCBP2 EIF3E MSH2 IQGAP3

2.79e-0575956835915203
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

USP36 FAT1 WDR36 IQGAP2 MUC16 RNF213 ZFHX3 CCT2

3.30e-0577756835844135
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

ROCK2 KIFBP IQGAP2 MYCBP2 UBR4 EIF3E DGKB UBE2M MSH2 ECPAS

3.44e-051284561017353931
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

ROCK2 TRPM4 FAT1 SLITRK2 IQGAP2 SLCO2B1 SLITRK4

3.50e-0556956730639242
Pubmed

Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue.

SLITRK2 SLITRK4

3.80e-05656214557068
Pubmed

The expanding beta 4-galactosyltransferase gene family: messages from the databanks.

B4GALT4 B4GALT3

3.80e-0565629597550
Pubmed

Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth.

SLITRK2 SLITRK4

3.80e-05656214550773
Pubmed

Differential expression of Slitrk family members in the mouse nervous system.

SLITRK2 SLITRK4

3.80e-05656219924824
Pubmed

IQ-motif selectivity in human IQGAP2 and IQGAP3: binding of calmodulin and myosin essential light chain.

IQGAP2 IQGAP3

3.80e-05656221299499
Pubmed

Novel locus including FGF21 is associated with dietary macronutrient intake.

RASIP1 FGF21

3.80e-05656223372041
Pubmed

Aggresomal sequestration and STUB1-mediated ubiquitylation during mammalian proteaphagy of inhibited proteasomes.

UBE3A UBR4 ECPAS

4.04e-054156332723828
Pubmed

The TIP60 Complex Is a Conserved Coactivator of HIF1A.

FAT1 MSH2 ECPAS IQGAP3

4.31e-0512056427320910
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

ROCK2 KIFBP XRN2 IQGAP2 MYCBP2 PTPRQ EIF3E MSH2 IQGAP3 TP53BP1

4.38e-051321561027173435
Pubmed

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.

WDR36 POLR1A IQGAP2 EIF3E IQGAP3 TP53BP1

4.45e-0540056635013556
Pubmed

Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases.

SLITRK2 SLITRK4

5.32e-05756223345436
Pubmed

Comparison of HPLC/ESI-FTICR MS versus MALDI-TOF/TOF MS for glycopeptide analysis of a highly glycosylated HIV envelope glycoprotein.

B4GALT4 B4GALT3

5.32e-05756218565761
Pubmed

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.

ROCK2 XRN2 WDR36 UBR4 EIF3E RNF213 CCT2 UBE2M ECPAS TP53BP1

5.83e-051367561032687490
Pubmed

A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.

IRF4 CDK10

7.09e-05856218483556
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

XRN2 WDR36 POLR1A MYCBP2 WDR6 TP53BP1

7.54e-0544056634244565
Pubmed

SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.

EFCAB5 KIFBP UBE3A EIF3E CCT2 UBE2M MSH2 ECPAS

7.77e-0587856837223481
Pubmed

Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.

WDR36 RNF213 CCT2 MSH2

8.76e-0514456435681168
Pubmed

VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.

KIFBP UBR4 CCT2 UBE2M TP53BP1

1.02e-0428856523383273
Pubmed

Systematic identification of factors for provirus silencing in embryonic stem cells.

UBR4 EIF3E MSH2 TP53BP1

1.11e-0415356426365490
Pubmed

Celastrol recruits UBE3A to recognize and degrade the DNA binding domain of steroid receptors.

USP2 UBE3A

1.14e-041056236109631
Pubmed

Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages.

IRF4 MSH2

1.14e-041056238636522
Pubmed

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.

USP36 XRN2 WDR36 POLR1A WDR6 CCT2

1.25e-0448356636912080
Pubmed

Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome.

CSN3 EIF3E

1.39e-041156212220626
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

ROCK2 XRN2 IQGAP2 UBR4 MSH2 ECPAS

1.48e-0449856636634849
Pubmed

IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade.

IQGAP2 IQGAP3

1.66e-041256218604197
Pubmed

Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.

UBE3A UBR4 ECPAS

1.68e-046656324811749
Pubmed

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.

SLITRK2 WDR36 CCT2 UBE2M FREM1

1.94e-0433156519490893
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

USP36 USP2 WDR36 POLR1A MYCBP2 EIF3E MSH2 TP53BP1

1.97e-04100556819615732
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

UBR4 RNF213 CCT2 MSH2 TP53BP1

1.97e-0433256532786267
Pubmed

Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC.

RASIP1 WDR6

2.29e-041456222354037
Pubmed

The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors.

KIFBP IQGAP2 WDR6 EIF3E CCT2

2.52e-0435056526549023
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

EFCAB5 FAT1 MUC16 RNF213 LYST FHIP1A

2.58e-0455256610737800
Pubmed

Characterization of Dynamic UbR-Proteasome Subcomplexes by In vivo Cross-linking (X) Assisted Bimolecular Tandem Affinity Purification (XBAP) and Label-free Quantitation.

CCT2 PIPSL ECPAS

2.76e-047856327114451
Pubmed

Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.

B4GALT4 B4GALT3

3.01e-041656210580128
Pubmed

Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning.

PTPRQ USH2A

3.01e-041656217567809
Pubmed

Human and mouse proteases: a comparative genomic approach.

USP36 USP2 FREM1

3.09e-048156312838346
Pubmed

Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.

EFCAB5 XRN2 MYCBP2 EIF3E CCT2 MSH2 ECPAS

3.09e-0480956732129710
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

ROCK2 KIFBP XRN2 CCT2 UBE2M MSH2

3.42e-0458256620467437
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

ROCK2 RNF213 MSH2 IQGAP3

3.58e-0420856433230847
Pubmed

Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.

IQGAP2 CCT2 MSH2 IQGAP3

3.78e-0421156417314511
Pubmed

Serological detection of cutaneous T-cell lymphoma-associated antigens.

UBE3A CTAGE1

3.83e-041856211149944
Pubmed

The nuclear import of the small GTPase Rac1 is mediated by the direct interaction with karyopherin alpha2.

IQGAP2 IQGAP3

3.83e-041856219961560
Pubmed

Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles.

WDR6 ECPAS IQGAP3

4.07e-048956327034005
Pubmed

Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.

ROCK2 POLR1A EIF3E CCT2 UBE2M MSH2 PIPSL

4.07e-0484756735235311
Pubmed

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.

RASIP1 UBE3A WDR6 UBR4 RNF213 IQGAP3

4.16e-0460456638803224
Pubmed

Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo.

RASIP1 FGF21

4.28e-041956221060863
Pubmed

Autoregulation of the 26S proteasome by in situ ubiquitination.

UBE3A UBR4

4.28e-041956224743594
Pubmed

Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance.

USP36 MSH2

4.28e-041956234188037
Pubmed

Genetic mapping of 20 novel expressed sequence tags from midgestation mouse embryos suggests chromosomal clustering.

LYST B4GALT3

4.28e-04195629070936
Pubmed

Human transcription factor protein interaction networks.

FAT1 XRN2 UBR4 EIF3E IRF4 ZFHX3 CCT2 UBE2M TP53BP1

4.32e-04142956935140242
Pubmed

GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.

XRN2 IQGAP2 UBR4 CCT2

4.50e-0422156429991511
Pubmed

Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.

DGKB ABCC11

4.75e-042056225187374
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

IQGAP2 MYCBP2 UBR4 EIF3E CCT2 UBE2M ECPAS IQGAP3

4.82e-04114956835446349
Pubmed

UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.

UBR4 RNF213

5.24e-042156237422473
Pubmed

CIF-1, a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans embryo.

CSN3 EIF3E

5.24e-042156217403899
Pubmed

Defining the membrane proteome of NK cells.

XRN2 MYCBP2 UBR4 EIF3E RNF213 IRF4 MSH2 ECPAS

5.37e-04116856819946888
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

XRN2 UBR4 EIF3E CCT2 MSH2 ECPAS

5.55e-0463856633239621
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

MYCBP2 WDR6 UBR4 ZFHX3 ECPAS

5.65e-0441856534709266
Pubmed

Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.

TRPM4 XRN2 WDR36 CCT2 UBE2M MSH2

5.69e-0464156636057605
Pubmed

Slitrk4 is required for the development of inhibitory neurons in the fear memory circuit of the lateral amygdala.

SLITRK2 SLITRK4

5.76e-042256238736483
Pubmed

∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.

UBR4 EIF3E ABCC11 CCT2 IQGAP3 TP53BP1

5.97e-0464756626618866
Pubmed

USP37 is a SNAI1 deubiquitinase.

USP36 USP2

6.87e-042456231911859
Pubmed

Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.

MYCBP2 UBE2M

7.46e-042556212522145
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

KIFBP POLR1A UBE3A UBR4 MSH2 ECPAS IQGAP3

7.64e-0494256731073040
Pubmed

Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.

XRN2 WDR36 POLR1A WDR6 CCT2

8.19e-0445456533226137
Pubmed

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.

USP2 WDR36 EIF3E RNF213

8.50e-0426256436880596
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

ROCK2 KIFBP IQGAP2 MYCBP2 UBE3A UBR4 TP53BP1

8.69e-0496356728671696
Pubmed

Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay.

UBE3A UBE2M

8.71e-042756230097011
Pubmed

Neddylation modification of the U3 snoRNA-binding protein RRP9 by Smurf1 promotes tumorigenesis.

WDR36 WDR6 EIF3E

9.03e-0411756334662580
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

ROCK2 WDR6 UBR4 MSH2 PIPSL ECPAS FN3K

9.28e-0497456728675297
Pubmed

Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction.

MYCBP2 UBR4

9.37e-042856235474067
Pubmed

Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.

USP36 XRN2 WDR36 TP53BP1

9.63e-0427156432433965
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

USP36 WDR36 MSH2 ECPAS TP53BP1

9.74e-0447256538943005
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

USP2 XRN2 MYCBP2 UBE3A UBR4 CCT2 FN3K B4GALT3

9.98e-04128556835914814
InteractionSIRT7 interactions

XRN2 WDR36 POLR1A MYCBP2 WDR6 UBR4 EIF3E CCT2 MSH2 ECPAS TP53BP1

2.98e-067445311int:SIRT7
InteractionSIRT6 interactions

FAT1 XRN2 WDR36 POLR1A MYCBP2 UBE3A WDR6 MSH2 IQGAP3 TP53BP1

4.68e-066285310int:SIRT6
InteractionATP1A1 interactions

USP36 WDR36 UBE3A RNF213 CCT2 UBE2M MSH2 ECPAS TP53BP1

1.70e-05575539int:ATP1A1
InteractionPOLR1G interactions

USP36 KIFBP XRN2 WDR36 POLR1A IQGAP2 UBR4 MSH2

3.85e-05489538int:POLR1G
InteractionGNB2 interactions

KIFBP FAT1 WDR36 LPIN2 RNF213 CCT2 MSH2 ECPAS

4.64e-05502538int:GNB2
InteractionPSMD4 interactions

USP36 KIFBP UBE3A UBE2M PIPSL ECPAS TP53BP1

4.78e-05368537int:PSMD4
InteractionRHOBTB1 interactions

ROCK2 WDR36 RNF213 CCT2 UBE2M

4.90e-05152535int:RHOBTB1
InteractionUTP18 interactions

USP36 XRN2 WDR36 WDR6 CCT2

4.90e-05152535int:UTP18
InteractionAATF interactions

USP36 XRN2 WDR36 POLR1A MYCBP2 WDR6 EIF3E

5.48e-05376537int:AATF
InteractionGRWD1 interactions

USP36 XRN2 WDR36 IQGAP2 UBR4 LPIN2 CCT2

6.90e-05390537int:GRWD1
InteractionBRCA1 interactions

USP2 XRN2 POLR1A UBE3A WDR6 UBR4 EIF3E CCT2 MSH2 ECPAS USH2A TP53BP1

7.58e-0512495312int:BRCA1
InteractionTRIM28 interactions

USP36 KIFBP XRN2 POLR1A IQGAP2 MYCBP2 UBE3A UBR4 CCT2 UBE2M MSH2 IQGAP3 TP53BP1

8.61e-0514745313int:TRIM28
InteractionTUBB4B interactions

USP36 KIFBP TCP11L2 MYCBP2 UBR4 CCT2 UBE2M ECPAS

9.96e-05560538int:TUBB4B
InteractionC9orf72 interactions

XRN2 POLR1A IQGAP2 MYCBP2 UBE3A WDR6 UBR4 EIF3E CCT2 MSH2 PIPSL IQGAP3

1.27e-0413195312int:C9orf72
InteractionRANGAP1 interactions

USP36 KIFBP MYCBP2 UBR4 UBE2M ECPAS

1.69e-04314536int:RANGAP1
InteractionNSUN2 interactions

ROCK2 KIFBP POLR1A UBE3A WDR6 TP53BP1

1.97e-04323536int:NSUN2
InteractionUTP15 interactions

USP36 XRN2 WDR36 PIPSL

2.00e-04110534int:UTP15
InteractionBBS1 interactions

ROCK2 KIFBP UBE3A OMD

2.07e-04111534int:BBS1
InteractionPSMD12 interactions

UBE3A WDR6 EIF3E UBE2M PIPSL ECPAS

2.25e-04331536int:PSMD12
InteractionUBE2L3 interactions

MYCBP2 UBE3A UBR4 RNF213 TP53BP1

2.29e-04211535int:UBE2L3
Cytoband17q25.3

USP36 RNF213 FN3K

2.63e-0410156317q25.3
Cytoband19q13.33

RASIP1 TRPM4 FGF21

3.03e-0410656319q13.33
CytobandXq27.3

SLITRK2 SLITRK4

9.47e-0437562Xq27.3
CytobandEnsembl 112 genes in cytogenetic band chr7p21

LRRC72 DGKB

5.35e-0389562chr7p21
CytobandEnsembl 112 genes in cytogenetic band chrXq27

SLITRK2 SLITRK4

5.58e-0391562chrXq27
CytobandEnsembl 112 genes in cytogenetic band chr17q25

USP36 RNF213 FN3K

6.32e-03307563chr17q25
GeneFamilyBeta 4-glycosyltransferases

B4GALT4 B4GALT3

5.44e-0417372425
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT1 SLITRK2 PTPRQ DGKB USH2A FREM1

1.18e-071845662cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT1 SLITRK2 PTPRQ DGKB USH2A FREM1

1.18e-07184566ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT1 SLITRK2 PTPRQ DGKB USH2A FREM1

1.18e-071845662b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_1-Mesothelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FAT1 SLITRK2 LRRC72 MUC16 C1R

2.89e-061775650912a291cff32a4ff8a2d7680ed1a1cd867fb90f
ToppCellCOPD-Epithelial-Mesothelial|World / Disease state, Lineage and Cell class

FAT1 PTPRQ MUC16 C1R FHIP1A

3.59e-0618556523579988036fc1925992c31919750f9b3fe9f790
ToppCellCOPD-Epithelial-Mesothelial|COPD / Disease state, Lineage and Cell class

FAT1 PTPRQ MUC16 C1R FHIP1A

3.98e-0618956579bb2593ad5d17f94b17972884241f03a0f43770
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Col6a1_Fezf2|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

LRRC72 IRF4 IQGAP3

2.33e-05445632aa44b57544d5264db5b265ae60f7460c5b2a217
ToppCell390C-Myeloid-Macrophage-SPP1+_Macrophage_2|390C / Donor, Lineage, Cell class and subclass (all cells)

EFCAB5 MTMR11 SLCO2B1 UBR4

4.33e-0515556415bacd06cc2b02b13c85bb71c5b758e5ff613e80
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRQ DGKB USH2A FREM1

4.90e-05160564c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRQ DGKB USH2A FREM1

4.90e-0516056425c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell10x5'v1-week_12-13-Hematopoietic-HSC/MPP_and_pro-MEP|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

CCNG1 EIF3E CCT2 FREM1

5.39e-0516456447355439e578d1b1a387fb4ee761162028abea4a
ToppCellControl-Epithelial-Mesothelial|Control / Disease state, Lineage and Cell class

FAT1 SLITRK2 MUC16 C1R

5.65e-051665641ed3788257e14f097862b999f020bfe2a57de52b
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-nan|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROCK2 TRPM4 WDR36 LPIN2

7.09e-051765641dd54bfaa58541de51e5a8328651d390833bd480
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.C1ql3_(VTA_(dorsal_VTA))-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

PTPRQ IQGAP3 FREM1

7.55e-05655634382d56d5f71c7acfe35f84db7257aba2a7dd36a
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.C1ql3_(VTA_(dorsal_VTA))|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

PTPRQ IQGAP3 FREM1

7.55e-056556305b712f83d88e864747cd0229a39aca17321e0f8
ToppCellIPF-Epithelial-Mesothelial|World / Disease state, Lineage and Cell class

FAT1 PTPRQ MUC16 C1R

8.25e-051835647df20e3172a1220ff427f30181f4f0c3b7fe2d42
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROCK2 XRN2 MYCBP2 LYST

8.42e-051845641154a5ad7b8512272b7476f949ddac350910bfb7
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

DGKB MUC16 ZFHX3 USH2A

8.78e-0518656423b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

WDR36 MYCBP2 RNF213 LYST

9.73e-051915649454f642c3621370fa23640b631301346b300950
ToppCellhuman_hepatoblastoma|World / Sample and Cell Type and Tumor Cluster (all cells)

ROCK2 XRN2 TCP11L2 EIF3E

1.01e-04193564e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TRAV3 FAT1 MUC16 FHIP1A

1.05e-04195564e7230a849ea31e6eef9bc6f5468938499450582d
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

IQGAP2 LPIN2 TRBV5-4 LYST

1.10e-041975641ca06d6d288cb58a6e8062ebc01831e58ee5be4b
ToppCellParenchymal-10x5prime-Stromal-Mesofibroblastic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SLITRK2 PTPRQ MUC16 C1R

1.10e-0419756488a86286b9c3ea3b076d7464faec42d0392ee7f8
ToppCellParenchymal-10x5prime-Stromal-Mesofibroblastic-Mesothelia|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SLITRK2 PTPRQ MUC16 C1R

1.10e-041975642773d2eb5f232a7e49da116efffcb6bf5eb90810
ToppCellPCW_13-14-Endothelial-Endothelial_cycling-endo_proliferating2_(14)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

RASIP1 SLCO2B1 TMEM255B IQGAP3

1.10e-041975648e655db7c6f04d49927a1f0a75178e5955b4af08
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW19-Macroglial-Astrocyte|GW19 / Sample Type, Dataset, Time_group, and Cell type.

FAT1 SLITRK2 IQGAP2 RNF213

1.12e-04198564bfad1c51cf884ff7ce89f8278820800582541dc7
ToppCellBiopsy_Other_PF-Mesenchymal-Mesothelial_cells|Biopsy_Other_PF / Sample group, Lineage and Cell type

SLITRK2 PTPRQ MUC16 C1R

1.12e-0419856486736f01e61bf4961f060b24ee1f1f48340737dd
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW19-Macroglial|GW19 / Sample Type, Dataset, Time_group, and Cell type.

FAT1 SLITRK2 IQGAP2 RNF213

1.12e-041985646372e65242236c497d9b3be147092897c1609d22
ToppCellMild-CD8+_T_activated|Mild / Disease group and Cell class

LPIN2 RNF213 IRF4 LYST

1.12e-04198564ceac1b51bacfd0dd7fe7c6a666f7927055e1f380
ToppCelldistal-1-mesenchymal-Mesothelial|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SLITRK2 PTPRQ MUC16 C1R

1.14e-041995648dd5b411d2f1626830b77a1616cc3fb67dc59338
ToppCellmyeloid-Dendritic_cell-Conventional_dendritic_cell|myeloid / Lineage, cell class and subclass

CCNG1 EIF3E IRF4 CCT2

1.14e-041995641e7ce1a1d6a7af18351d64b7a5334efa6dd9abc5
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

USP36 IQGAP2 SLCO2B1 UBR4

1.14e-04199564667b8b47a5b388506e3177b46747267fad8024f6
ToppCellmyeloid-Dendritic_cell|myeloid / Lineage, cell class and subclass

CCNG1 EIF3E IRF4 CCT2

1.14e-04199564b81c0a40481f1006ac4aa8759af95448cb5fc2e6
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

IQGAP2 RNF213 IRF4 CCT2

1.14e-04199564f3cc3cda38f78d1d12d865df339d93c5fecf19f2
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

IQGAP2 RNF213 IRF4 CCT2

1.14e-04199564c3c73c9404a73133bfad1f9ced292f5e508ef767
ToppCellLPS_only-Endothelial-Endothelial-Activated_Gen_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

ROCK2 RASIP1 SLCO2B1 RNF213

1.16e-042005646f531a418ff25b59a543800cf4bce7b72404ce08
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Macroglial|GW19 / Sample Type, Dataset, Time_group, and Cell type.

FAT1 SLITRK2 IQGAP2 RNF213

1.16e-042005643a954d9d542e52c9b181f0850a09b1bff0a0c82d
ToppCellLPS_IL1RA-Endothelial-Endothelial-Activated_Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ROCK2 RASIP1 SLCO2B1 RNF213

1.16e-042005642d07237022b409c4fac6fcf99b68c8affb3007cd
ToppCellLPS_only-Endothelial-Endothelial-Activated_Alv_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

ROCK2 RASIP1 SLCO2B1 RNF213

1.16e-04200564edb64556b3fefe3144f73b6efe23b9ffd34091d2
ToppCellLPS_only-Mesenchymal_myocytic-Pericyte-Pericyte_2|LPS_only / Treatment groups by lineage, cell group, cell type

EFCAB5 FAT1 SLITRK2 ZFHX3

1.16e-0420056469edc375d85689300d1dbc1217fedc40063ecdcb
Diseaseprotein intake measurement

RASIP1 FGF21

1.36e-0410522EFO_0010810
Diseaseretinal vasculature measurement

RASIP1 USP2 XRN2 EIF3E DGKB IRF4

2.89e-04517526EFO_0010554
Diseasesuicidal ideation

WDR36 ZFHX3

1.20e-0329522EFO_0004320
Diseasecarbohydrate intake measurement

FGF21 ZFHX3

1.65e-0334522EFO_0010811
Diseaseovarian neoplasm

MUC16 MSH2 TP53BP1

1.72e-03134523C0919267
DiseasePR interval

EFCAB5 FAT1 MYCBP2 LPIN2 DGKB

1.77e-03495525EFO_0004462

Protein segments in the cluster

PeptideGeneStartEntry
HPFLQRQQLAYGIYV

B4GALT3

146

O60512
IQNFYLPQNYIDQFL

CTAGE1

26

Q9HC47
PFLQRQQLDYGIYVI

B4GALT4

146

O60513
IQNLQPQYQFRDYFI

C1R

321

P00736
APSNRPYFLLLQGYQ

RASIP1

376

Q5U651
QFLQLYYSLLQENLP

CCNG1

156

P51959
RQRFNLNQYLPNFYP

FAT1

4481

Q14517
YAPQNLSIRGEYQIN

MUC16

14191

Q8WXI7
EPLLARQLYYFAQQN

IRF4

406

Q15306
RYSNAQILQFQNPGY

MTMR11

521

A4FU01
RLYRYQFDPNLGIRQ

ECPAS

1126

Q5VYK3
PLLQFGGQVRQRYLY

FGF21

36

Q9NSA1
IYYVFERLPQNGQLQ

FREM1

1311

Q5H8C1
NPQLSFYQLVYGLNA

ABCC11

856

Q96J66
VGNLLYYRFLNPAVV

IQGAP3

1171

Q86VI3
NLYLQYNQVSFVPRG

LRRC70

136

Q7Z2Q7
PGYYINLNQNPRTLL

PIPSL

156

A2A3N6
QPNGNIQVYQALVYR

PTPRQ

1711

Q9UMZ3
INYLGEYLIRNNPNY

EFCAB5

211

A4FU69
PLIRNQLVNYIYNGF

FHIP1A

301

Q05DH4
QLVNYIYNGFLVPVL

FHIP1A

306

Q05DH4
LVGQYSLRKQPYNNL

CDK10

271

Q15131
QGERIYRKFQYLLNP

DGKB

451

Q9Y6T7
NIIDLFLYQPQYLNA

EIF3E

231

P60228
YNYIFNPVLQRGVEL

LYST

731

Q99698
NLYQRRPAIAINNPY

CSN3

61

P07498
LQDCYRLYQGINQLP

MSH2

401

P43246
LNPQYYLLVNRQIQF

KIFBP

461

Q96EK5
QNPLCQYNLYRLYII

LRRC72

146

A6NJI9
FYIPRNLEHLYLQNN

OMD

296

Q99983
YLNGNQIERLYPEIF

SLITRK4

431

Q8IW52
QSNGPIIYYILLRNG

USH2A

3526

O75445
QLRFQFLPHAYYQQE

POLR1A

1316

O95602
LNKQVYGPFYANILR

TCP11L2

486

Q8N4U5
YNPAQQILAYAGFRL

TMEM255B

241

Q8WV15
QQLFYLLQTNPLYLA

IQGAP2

886

Q13576
PGFDQRLLLYQLFNY

FN3K

271

Q9H479
LLQPPQYRIYQLFLN

SLITRK2

56

Q9H156
GNLLTRLYPNEFVNY

SLITRK2

71

Q9H156
GINCFINRQLIYNYP

CCT2

286

P78371
INRQLIYNYPEQLFG

CCT2

291

P78371
NQTRGQIPQILYYRS

MYCBP2

1871

O75592
RPYQYLRRFNQNQDL

RNF213

2166

Q63HN8
YSLVQGQQLNPYLRL

UBE3A

511

Q05086
YYNNDLLRNRFIGLQ

SLCO2B1

641

O94956
YQGNLYRPLLRGQAQ

XRN2

841

Q9H0D6
NQLPFIGFTYYRENL

ROCK2

406

O75116
HANQLQNYRNYLLPA

TP53BP1

1836

Q12888
QALGQGPQFIFQYYR

TRBV5-4

56

A0A0C4DH59
YYQLFVRDGQLQPVL

WDR6

591

Q9NNW5
VQYPNRGLQFLLKYI

TRAV3

56

A0A0B4J244
TQIQRYAPRFVGYNQ

USP2

341

O75604
LNLPYFLRYINRFQD

UBR4

261

Q5T4S7
NSIIYGLQYLFLEPN

UBE2M

126

P61081
VFYRPYLQIFGQIPQ

TRPM4

966

Q8TD43
LNQQAYVLFYLRIPG

USP36

411

Q9P275
LYQYYLAQNMNLPNL

ZFHX3

861

Q15911
PLTNIRYYGQNGQQI

WDR36

381

Q8NI36
DNPNLVIRIYNRYYN

LPIN2

506

Q92539