Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionubiquitin conjugating enzyme activity

UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2S TAF1

1.67e-07371356GO:0061631
GeneOntologyMolecularFunctionubiquitin-like protein conjugating enzyme activity

UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2S TAF1

4.24e-07431356GO:0061650
GeneOntologyMolecularFunctionRNA polymerase II activity

POLR2J3 POLR2A POLR2J POLR2J2

6.36e-07111354GO:0001055
GeneOntologyMolecularFunctionDNA-directed 5'-3' RNA polymerase activity

POLR2J3 POLR2A POLR2J POLR2J2

4.78e-05301354GO:0003899
GeneOntologyMolecularFunction5'-3' RNA polymerase activity

POLR2J3 POLR2A POLR2J POLR2J2

6.20e-05321354GO:0034062
GeneOntologyMolecularFunctionRNA polymerase activity

POLR2J3 POLR2A POLR2J POLR2J2

6.20e-05321354GO:0097747
GeneOntologyMolecularFunctionnucleotidyltransferase activity

POLR2J3 POLR2A POLR2J PNPT1 PARP4 POLR2J2 UBA6

7.91e-051521357GO:0016779
GeneOntologyMolecularFunctioncatalytic activity, acting on a nucleic acid

DDX59 VPS72 ATRX POLR2J3 POLR2A POLR2J FANCM THAP9 PNPT1 RECQL5 POLR2J2 PARN CNOT1

4.38e-0464513513GO:0140640
GeneOntologyMolecularFunctionATPase inhibitor activity

FNIP2 FNIP1

6.69e-0461352GO:0042030
GeneOntologyMolecularFunctionfour-way junction helicase activity

FANCM RECQL5

6.69e-0461352GO:0009378
GeneOntologyMolecularFunctionbitter taste receptor activity

TAS2R36 TAS2R30 TAS2R46

7.85e-04271353GO:0033038
GeneOntologyMolecularFunctionalpha-(1->3)-fucosyltransferase activity

FUT10 FUT6

1.24e-0381352GO:0046920
GeneOntologyMolecularFunctiontaste receptor activity

TAS2R36 TAS2R30 TAS2R46

1.42e-03331353GO:0008527
GeneOntologyMolecularFunctionpoly(U) RNA binding

RBMS2 PNPT1 RBMS3

1.55e-03341353GO:0008266
GeneOntologyBiologicalProcessprotein K29-linked ubiquitination

UBE2D2 UBE2D3 UBE2D4 UBE2S

1.13e-06131334GO:0035519
GeneOntologyBiologicalProcessprotein K27-linked ubiquitination

UBE2D2 UBE2D3 UBE2D4 UBE2S

1.57e-06141334GO:0044314
GeneOntologyBiologicalProcessprotein K6-linked ubiquitination

UBE2D2 UBE2D3 UBE2D4 UBE2S

3.68e-06171334GO:0085020
GeneOntologyBiologicalProcessprotein K11-linked ubiquitination

AREL1 UBE2D2 UBE2D3 UBE2D4 UBE2S

3.82e-06371335GO:0070979
GeneOntologyCellularComponentRNA polymerase II, holoenzyme

POLR2J3 POLR2A POLR2J POLR2J2 TAF1 TAF4B TAF10

1.78e-06891357GO:0016591
GeneOntologyCellularComponentRNA polymerase II, core complex

POLR2J3 POLR2A POLR2J POLR2J2

3.71e-06171354GO:0005665
GeneOntologyCellularComponentnuclear DNA-directed RNA polymerase complex

POLR2J3 POLR2A POLR2J POLR2J2 TAF1 TAF4B TAF10

8.76e-061131357GO:0055029
GeneOntologyCellularComponentDNA-directed RNA polymerase complex

POLR2J3 POLR2A POLR2J POLR2J2 TAF1 TAF4B TAF10

1.04e-051161357GO:0000428
GeneOntologyCellularComponentRNA polymerase complex

POLR2J3 POLR2A POLR2J POLR2J2 TAF1 TAF4B TAF10

1.23e-051191357GO:0030880
GeneOntologyCellularComponentnuclear protein-containing complex

FLNA THEMIS POLR2J3 POLR2A POLR2J RGPD1 FANCM ADAR MEN1 THOC6 PBRM1 PRPF4 ABRAXAS1 NXF5 POLR2J2 SUGP1 UBE2S TAF1 TAF4B TAF10 MGA SEC13

7.06e-05137713522GO:0140513
GeneOntologyCellularComponenttransferase complex

VPS72 POLR2J3 POLR2A POLR2J RGPD1 MEN1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 POLR2J2 UBE2S TAF1 TAF4B FUT6 TAF10 MGA

1.60e-0496313517GO:1990234
GeneOntologyCellularComponentmembrane attack complex

C5 C7

8.51e-0471352GO:0005579
GeneOntologyCellularComponentMLL1 complex

MEN1 TAF1 MGA

1.14e-03321353GO:0071339
GeneOntologyCellularComponentMLL1/2 complex

MEN1 TAF1 MGA

1.25e-03331353GO:0044665
DomainUBQ-conjugating_AS

UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2S

7.46e-07251315IPR023313
DomainRNA_POL_L_13KD

POLR2J3 POLR2J POLR2J2

1.34e-0641313PS01154
DomainRNA_pol_Rpb11_13-16kDa_CS

POLR2J3 POLR2J POLR2J2

1.34e-0641313IPR008193
DomainRBP11-like_dimer

POLR2J3 POLR2J POLR2J2

6.64e-0661313IPR009025
DomainRNA_pol_L

POLR2J3 POLR2J POLR2J2

6.64e-0661313PF01193
DomainUQ_con

UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2S

7.48e-06391315PF00179
DomainUBIQUITIN_CONJUGAT_1

UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2S

8.50e-06401315PS00183
DomainUBIQUITIN_CONJUGAT_2

UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2S

9.62e-06411315PS50127
DomainUBQ-conjugat_E2

UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2S

9.62e-06411315IPR000608
Domain-

UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2S

2.85e-055113153.10.110.10
DomainUBQ-conjugating_enzyme/RWD

UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2S

3.44e-05531315IPR016135
DomainIG_FLMN

FLNA FLNB AREL1

3.90e-05101313SM00557
DomainFNIP_N_dom

FNIP2 FNIP1

4.88e-0521312IPR028084
DomainFNIP_mid_dom

FNIP2 FNIP1

4.88e-0521312IPR028085
DomainFNIP_C_dom

FNIP2 FNIP1

4.88e-0521312IPR028086
DomainFNIP_C

FNIP2 FNIP1

4.88e-0521312PF14638
DomainFNIP_M

FNIP2 FNIP1

4.88e-0521312PF14637
DomainFNIP_N

FNIP2 FNIP1

4.88e-0521312PF14636
DomainFNIP_fam

FNIP2 FNIP1

4.88e-0521312IPR026156
DomainFilamin

FLNA FLNB AREL1

5.34e-05111313PF00630
DomainFILAMIN_REPEAT

FLNA FLNB AREL1

5.34e-05111313PS50194
DomainFilamin/ABP280_rpt

FLNA FLNB AREL1

5.34e-05111313IPR001298
DomainFilamin/ABP280_repeat-like

FLNA FLNB AREL1

5.34e-05111313IPR017868
DomainRNA_pol_L_2

POLR2J POLR2J2

1.46e-0431312PF13656
DomainDOCK_N

DOCK3 DOCK4

4.82e-0451312PF16172
DomainDOCK_N

DOCK3 DOCK4

4.82e-0451312IPR032376
DomainGlyco_transf_10

FUT10 FUT6

1.33e-0381312PF00852
DomainGlyco_tran_10_N

FUT10 FUT6

1.33e-0381312PF17039
DomainGlyco_tran_10_N

FUT10 FUT6

1.33e-0381312IPR031481
DomainGlyco_trans_10

FUT10 FUT6

1.33e-0381312IPR001503
PathwayREACTOME_HIV_TRANSCRIPTION_INITIATION

POLR2A POLR2J TAF1 TAF4B TAF10

2.73e-05471075M29568
PathwayREACTOME_REGULATION_OF_TNFR1_SIGNALING

TRAF1 UBE2D1 UBE2D2 UBE2D3 USP4

2.73e-05471075MM15179
PathwayKEGG_RNA_POLYMERASE

POLR2J3 POLR2A POLR2J POLR2J2

6.44e-05291074M1724
PathwayREACTOME_TNF_SIGNALING

TRAF1 UBE2D1 UBE2D2 UBE2D3 USP4

6.44e-05561075MM15453
PathwayREACTOME_TNF_SIGNALING

TRAF1 UBE2D1 UBE2D2 UBE2D3 USP4

7.02e-05571075M27713
PathwayREACTOME_SYNTHESIS_OF_ACTIVE_UBIQUITIN_ROLES_OF_E1_AND_E2_ENZYMES

UBE2D1 UBE2D2 UBA6 UBE2S

7.39e-05301074M27762
PathwayREACTOME_SYNTHESIS_OF_ACTIVE_UBIQUITIN_ROLES_OF_E1_AND_E2_ENZYMES

UBE2D1 UBE2D2 UBA6 UBE2S

7.39e-05301074MM15507
PathwayKEGG_MEDICUS_REFERENCE_TRANSCRIPTION_COUPLED_NER

POLR2J3 POLR2A POLR2J POLR2J2

8.43e-05311074M47825
PathwayREACTOME_PROTEIN_UBIQUITINATION

UBE2D1 UBE2D2 UBE2D3 UBA6 UBE2S

1.32e-04651075MM15490
PathwayREACTOME_TRANSCRIPTION_OF_THE_HIV_GENOME

POLR2A POLR2J TAF1 TAF4B TAF10

1.88e-04701075M27008
PathwayREACTOME_INACTIVATION_OF_CSF3_G_CSF_SIGNALING

UBE2D1 UBE2D2 UBE2D3

3.19e-04181073MM15680
PathwayREACTOME_PROTEIN_UBIQUITINATION

UBE2D1 UBE2D2 UBE2D3 UBA6 UBE2S

3.31e-04791075M27742
PathwayREACTOME_RNA_POLYMERASE_II_PRE_TRANSCRIPTION_EVENTS

POLR2A POLR2J TAF1 TAF4B TAF10

3.72e-04811075M865
PathwayREACTOME_TICAM1_RIP1_MEDIATED_IKK_COMPLEX_RECRUITMENT

UBE2D1 UBE2D2 UBE2D3

3.77e-04191073M27020
PathwayWP_PYRIMIDINE_METABOLISM

POLR2J3 POLR2A POLR2J PNPT1 POLR2J2

4.40e-04841075M48340
PathwayREACTOME_RNA_POLYMERASE_II_PROMOTER_ESCAPE

POLR2A TAF1 TAF4B TAF10

4.72e-04481074MM15424
PathwayREACTOME_BLOOD_GROUP_SYSTEMS_BIOSYNTHESIS

FUT10 ST3GAL6 FUT6

5.12e-04211073M27917
PathwayKEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS

UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBA6 UBE2S

5.65e-041351076M15247
PathwayREACTOME_SIGNALING_BY_CSF3_G_CSF

UBE2D1 UBE2D2 UBE2D3

5.89e-04221073MM15675
PathwayREACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1

UBE2D1 UBE2D2 UBE2D3

6.74e-04231073M1003
PathwayKEGG_MEDICUS_REFERENCE_SIALYL_LEWIS_X_ANTIGEN_BIOSYNTHESIS

ST3GAL6 FUT6

8.39e-0461072M47967
PathwayREACTOME_INACTIVATION_OF_CSF3_G_CSF_SIGNALING

UBE2D1 UBE2D2 UBE2D3

8.66e-04251073M41829
PathwayREACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1

UBE2D1 UBE2D2 UBE2D3

8.66e-04251073MM15646
PathwayKEGG_PYRIMIDINE_METABOLISM

POLR2J3 POLR2A POLR2J PNPT1 POLR2J2

8.90e-04981075M5109
PathwayREACTOME_HIV_LIFE_CYCLE

POLR2A POLR2J TAF1 TAF4B TAF10 SEC13

9.48e-041491076M4076
PathwayKEGG_MEDICUS_REFERENCE_COMMON_PATHWAY_OF_COMPLEMENT_CASCADE_MAC_FORMATION

C5 C7

1.17e-0371072M47873
PathwayREACTOME_PEROXISOMAL_PROTEIN_IMPORT

UBE2D1 UBE2D2 UBE2D3 NOS2

1.32e-03631074M27915
PathwayREACTOME_SIGNALING_BY_CSF3_G_CSF

UBE2D1 UBE2D2 UBE2D3

1.49e-03301073M41825
PathwayREACTOME_PEROXISOMAL_PROTEIN_IMPORT

UBE2D1 UBE2D2 UBE2D3 NOS2

1.49e-03651074MM15628
PathwayBIOCARTA_ALTERNATIVE_PATHWAY

C5 C7

1.55e-0381072MM1582
PathwayREACTOME_TERMINAL_PATHWAY_OF_COMPLEMENT

C5 C7

1.55e-0381072MM14656
PathwayREACTOME_TERMINAL_PATHWAY_OF_COMPLEMENT

C5 C7

1.55e-0381072M27006
Pubmed

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

HECW1 AREL1 UBE2D1 UBE2D2 UBE2D3 UBE2S

6.91e-1026136626949039
Pubmed

Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.

HECW1 AREL1 UBE2D1 UBE2D2 UBE2D3

3.58e-0916136525723849
Pubmed

The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor.

UBE2D1 UBE2D2 UBE2D3 UBE2D4

7.76e-097136421685362
Pubmed

Analysis of the Zn-Binding Domains of TRIM32, the E3 Ubiquitin Ligase Mutated in Limb Girdle Muscular Dystrophy 2H.

UBE2D1 UBE2D2 UBE2D3 UBE2D4

7.76e-097136430884854
Pubmed

Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity.

UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2S

9.45e-0919136527425610
Pubmed

Ube2W conjugates ubiquitin to α-amino groups of protein N-termini.

UBE2D1 UBE2D2 UBE2D3 UBE2D4

1.55e-088136423560854
Pubmed

Inhibition of UVSSA ubiquitination suppresses transcription-coupled nucleotide excision repair deficiency caused by dissociation from USP7.

UBE2D1 UBE2D2 UBE2D3 UBE2D4

1.55e-088136429323787
Pubmed

The MALDI-TOF E2/E3 Ligase Assay as Universal Tool for Drug Discovery in the Ubiquitin Pathway.

UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2S

2.70e-0823136530017913
Pubmed

TRAF-interacting protein (TRIP) is a RING-dependent ubiquitin ligase.

TRAF1 UBE2D1 UBE2D2 UBE2D3

2.78e-089136417544371
Pubmed

Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity.

UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2S

3.40e-0824136524647965
Pubmed

Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging.

UBE2D1 UBE2D2 UBE2D3 UBA6 UBE2S

4.24e-0825136517597759
Pubmed

Mechanism and chain specificity of RNF216/TRIAD3, the ubiquitin ligase mutated in Gordon Holmes syndrome.

UBE2D1 UBE2D2 UBE2D3 UBE2D4

4.61e-0810136431087003
Pubmed

Osmotic and heat stress-dependent regulation of MLK4β and MLK3 by the CHIP E3 ligase in ovarian cancer cells.

UBE2D1 UBE2D2 UBE2D3 UBE2D4

4.61e-0810136428757353
Pubmed

The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2S

5.23e-0826136520061386
Pubmed

Identification of a family of closely related human ubiquitin conjugating enzymes.

UBE2D1 UBE2D2 UBE2D3

5.85e-08313638530467
Pubmed

Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay.

UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2S

6.40e-0827136530097011
Pubmed

E1-E2 interactions in ubiquitin and Nedd8 ligation pathways.

UBE2D1 UBE2D2 UBE2D3 UBE2S

1.08e-0712136422069333
Pubmed

The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes.

UBE2D1 UBE2D2 UBE2D3 UBE2D4

1.08e-0712136424211586
Pubmed

Ubiquitination of STING at lysine 224 controls IRF3 activation.

UBE2D1 UBE2D2 UBE2D3 UBE2D4

1.56e-0713136428763789
Pubmed

Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.

UBE2D1 UBE2D2 UBE2D3 UBE2D4

2.17e-0714136436481767
Pubmed

[New genes on human chromosome 7: bioinformatic analysis of a gene cluster from the POLR2J family].

POLR2J3 POLR2J POLR2J2

2.33e-074136315586814
Pubmed

A human RNA polymerase II subunit is encoded by a recently generated multigene family.

POLR2J3 POLR2J POLR2J2

2.33e-074136311747469
Pubmed

Physical and functional interactions between ZIP kinase and UbcH5.

UBE2D1 UBE2D2 UBE2D3

2.33e-074136318515077
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

DOCK4 DNAJA2 PKD1L1 RGPD1 CEP192 CLIP1 MEN1 PLEKHG1 OCIAD1 ALMS1 MTUS1 CAPN7 PIN4 COBL MGA CNOT1

2.52e-078531361628718761
Pubmed

The general transcription factors of RNA polymerase II.

POLR2A POLR2J TAF1 TAF4B TAF10

4.39e-073913658946909
Pubmed

Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes.

POLR2A POLR2J TAF1 TAF4B TAF10

4.39e-073913659054383
Pubmed

Three transitions in the RNA polymerase II transcription complex during initiation.

POLR2A POLR2J TAF1 TAF4B TAF10

4.39e-073913659405375
Pubmed

ATP activates transcription initiation from promoters by RNA polymerase II in a reversible step prior to RNA synthesis.

POLR2A POLR2J TAF1 TAF4B TAF10

5.01e-074013652449431
Pubmed

Abortive initiation is increased only for the weakest members of a set of down mutants of the adenovirus 2 major late promoter.

POLR2A POLR2J TAF1 TAF4B TAF10

5.01e-074013651939271
Pubmed

Functional interaction of ubiquitin ligase RNF167 with UBE2D1 and UBE2N promotes ubiquitination of AMPA receptor.

UBE2D1 UBE2D2 UBE2D3 UBE2D4

5.12e-0717136433650289
Pubmed

Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid-liquid phase separation-based method.

UBE2D1 UBE2D2 UBE2D3 UBE2D4

5.12e-0717136436563856
Pubmed

E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1).

UBE2D1 UBE2D2 UBE2D3

5.82e-075136315684077
Pubmed

Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair.

UBE2D1 UBE2D2 UBE2D3

5.82e-075136326502057
Pubmed

Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.

UBE2D1 UBE2D2 UBE2D3

5.82e-075136325327252
Pubmed

The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase.

UBE2D1 UBE2D2 UBE2D3

5.82e-075136314562029
Pubmed

Tripartite motif ligases catalyze polyubiquitin chain formation through a cooperative allosteric mechanism.

UBE2D1 UBE2D2 UBE2D3

5.82e-075136323408431
Pubmed

Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation.

UBE2D1 UBE2D2 UBE2D3

5.82e-075136319741096
Pubmed

Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53.

UBE2D1 UBE2D2 UBE2D3

5.82e-07513638090726
Pubmed

ADP-ribosylation factor domain protein 1 (ARD1), a multifunctional protein with ubiquitin E3 ligase, GAP, and ARF domains.

UBE2D1 UBE2D2 UBE2D3

5.82e-075136316413270
Pubmed

The RING domain of mitochondrial E3 ubiquitin ligase 1 and its complex with Ube2D2: crystallization and X-ray diffraction.

UBE2D1 UBE2D2 UBE2D3

5.82e-075136331929179
Pubmed

The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11.

POLR2J3 POLR2J POLR2J2

5.82e-075136312036295
Pubmed

Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis.

UBE2D1 UBE2D2 UBE2D3

5.82e-075136323509263
Pubmed

Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat.

POLR2A POLR2J TAF1 TAF4B TAF10

1.02e-064613658849451
Pubmed

Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1.

UBE2D1 UBE2D2 UBE2D3

1.16e-066136322124327
Pubmed

h-Goliath, paralog of GRAIL, is a new E3 ligase protein, expressed in human leukocytes.

UBE2D1 UBE2D2 UBE2D3

1.16e-066136316549277
Pubmed

The E3 ubiquitin ligase TRIM32 regulates myoblast proliferation by controlling turnover of NDRG2.

UBE2D1 UBE2D2 UBE2D3

1.16e-066136325701873
Pubmed

Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology.

UBE2D1 UBE2D2 UBE2D3

1.16e-066136330404641
Pubmed

Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination.

UBE2D1 UBE2D2 UBE2D3

1.16e-066136327678051
Pubmed

Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo.

UBE2D1 UBE2D2 UBE2D3

1.16e-066136315280377
Pubmed

Negative regulation of the RLH signaling by the E3 ubiquitin ligase RNF114.

UBE2D1 UBE2D2 UBE2D3

1.16e-066136328625874
Pubmed

ASB2 targets filamins A and B to proteasomal degradation.

FLNA FLNB UBE2D1

1.16e-066136318799729
Pubmed

NEDD4 regulates ubiquitination and stability of the cell adhesion molecule IGPR-1 via lysosomal pathway.

UBE2D1 UBE2D2 UBE2D3

1.16e-066136333962630
Pubmed

c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling.

UBE2D1 UBE2D2 UBE2D3 UBE2S

1.27e-0621136421113135
Pubmed

Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.

FLNA FLNB PSAT1 HSDL2 POLR2A DNAJA2 ADAR LAP3 MEN1 PNPT1 UBE2D2 CNOT1

1.37e-065341361235032548
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

RASA2 HSDL2 RGPD1 MUC16 WDR19 PARP4 PBRM1 NXF5 SUGP1 C5 CNOT1 CDH17 AHNAK2

1.45e-066381361331182584
Pubmed

HERC5/IFI16/p53 signaling mediates breast cancer cell proliferation and migration.

HECW1 UBE2D1 UBE2D2 UBE2D3 UBA6 UBE2S

1.52e-0690136635671810
Pubmed

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.

VPS72 POLR2A RGPD1 MEN1 MGA CNOT1 SEC13

1.85e-06146136723892456
Pubmed

A ubiquitin ligase complex assembles linear polyubiquitin chains.

UBE2D1 UBE2D2 UBE2D3

2.02e-067136317006537
Pubmed

Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein.

UBE2D1 UBE2D2 UBE2D3

2.02e-067136324831002
Pubmed

UbcH8 regulates ubiquitin and ISG15 conjugation to RIG-I.

UBE2D1 UBE2D2 UBE2D3

2.02e-067136317719635
Pubmed

RNF122: a novel ubiquitin ligase associated with calcium-modulating cyclophilin ligand.

UBE2D1 UBE2D2 UBE2D3

2.02e-067136320553626
Pubmed

The E3 ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu.

UBE2D1 UBE2D2 UBE2D3

2.02e-067136325278022
Pubmed

Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate.

UBE2D1 UBE2D2 UBE2D3

2.02e-067136320347421
Pubmed

Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes.

UBE2D1 UBE2D2 UBE2D3

2.02e-067136320051513
Pubmed

Measuring rates of ubiquitin chain formation as a functional readout of ligase activity.

UBE2D1 UBE2D2 UBE2D3

2.02e-067136322350887
Pubmed

In Vitro Analysis of E3 Ubiquitin Ligase Function.

UBE2D1 UBE2D2 UBE2D3

2.02e-067136334057440
Pubmed

The E3 Ubiquitin Ligase NEDD4L Targets OGG1 for Ubiquitylation and Modulates the Cellular DNA Damage Response.

UBE2D1 UBE2D2 UBE2D3

2.02e-067136333282879
Pubmed

Selective recognition of viral promoters by host cell transcription complexes: challenges and opportunities to control latency.

POLR2A POLR2J TAF1 TAF10

2.24e-0624136423827503
Pubmed

Reconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes.

UBE2D1 UBE2D2 UBE2D3 UBE2D4

2.24e-0624136434195792
Pubmed

The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function.

POLR2A POLR2J TAF1 TAF10

2.65e-0625136419240132
Pubmed

Structure and catalytic activation of the TRIM23 RING E3 ubiquitin ligase.

UBE2D2 UBE2D3 UBE2D4

3.23e-068136328681414
Pubmed

The mechanism of neural precursor cell expressed developmentally down-regulated 4-2 (Nedd4-2)/NEDD4L-catalyzed polyubiquitin chain assembly.

UBE2D1 UBE2D2 UBE2D3

3.23e-068136328972136
Pubmed

Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation.

UBE2D1 UBE2D2 UBE2D3

3.23e-068136318838541
Pubmed

MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac.

UBE2D1 UBE2D2 UBE2D3

3.23e-068136325207814
Pubmed

A novel route for F-box protein-mediated ubiquitination links CHIP to glycoprotein quality control.

UBE2D1 UBE2D2 UBE2D3

3.23e-068136316682404
Pubmed

The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.

UBE2D1 UBE2D2 UBE2D3

3.23e-068136312670957
Pubmed

Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53.

UBE2D1 UBE2D2 UBE2D3

3.23e-068136315247280
Pubmed

Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation.

UBE2D1 UBE2D2 UBE2D3

3.23e-068136314661060
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

DOCK4 SPIRE2 VPS72 RBMS2 DNAJA2 ARHGAP4 C3P1 JRK USP4 TAF4B PLEKHH2 TAF10 MGA

3.37e-066891361336543142
Pubmed

Functional interactions between ubiquitin E2 enzymes and TRIM proteins.

UBE2D1 UBE2D2 UBE2D3 UBE2D4

3.66e-0627136421143188
Pubmed

Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181.

UBE2D1 UBE2D2 UBE2D3

4.83e-069136326711259
Pubmed

Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO.

UBE2D1 UBE2D2 UBE2D3

4.83e-069136312525502
Pubmed

Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125.

UBE2D1 UBE2D2 UBE2D3

4.83e-069136317460044
Pubmed

Comparison of Cross-Regulation by Different OTUB1:E2 Complexes.

UBE2D1 UBE2D2 UBE2D3

4.83e-069136332049508
Pubmed

Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis.

UBE2D1 UBE2D3 UBE2D4 UBE2S

6.48e-0631136425527291
Pubmed

Targeting ubiquitin conjugating enzyme UbcH5b by a triterpenoid PC3-15 from Schisandra plants sensitizes triple-negative breast cancer cells to lapatinib.

UBE2D2 UBE2D3 UBE2S

6.88e-0610136333607208
Pubmed

Inflammasome activation and metabolic remodelling in p16-positive aging cells aggravates high-fat diet-induced lung fibrosis by inhibiting NEDD4L-mediated K48-polyubiquitin-dependent degradation of SGK1.

UBE2D1 UBE2D2 UBE2D3

6.88e-0610136337345264
Pubmed

Bag1 directly routes immature BCR-ABL for proteasomal degradation.

UBE2D1 UBE2D2 UBE2D3

6.88e-0610136320675402
Pubmed

E2 conjugating enzyme selectivity and requirements for function of the E3 ubiquitin ligase CHIP.

UBE2D1 UBE2D2 UBE2D3

6.88e-0610136321518764
Pubmed

The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.

VWA8 ADAR LAP3 PBRM1 UBE2D3 RPL3 CNOT1 SEC13

7.41e-06253136829911972
Pubmed

Structural and functional consequences of NEDD8 phosphorylation.

DNAJA2 UBE2D2 UBE2D3 UBE2S USP4

8.38e-0670136534642328
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

FLNA DSC1 HSDL2 VWA8 POLR2A DNAJA2 CLIP1 PNPT1 JRK COBL PLEKHH2 MGA SEC13

8.85e-067541361335906200
Pubmed

A dimer-monomer switch controls CHIP-dependent substrate ubiquitylation and processing.

UBE2D1 UBE2D2 UBE2D3

9.43e-0611136336027913
Pubmed

Reconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: identification of the active components and JAK2 and gp130 as substrates.

UBE2D1 UBE2D2 UBE2D3

9.43e-0611136324438103
Pubmed

Dynamic interactions of proteins in complex networks: identifying the complete set of interacting E2s for functional investigation of E3-dependent protein ubiquitination.

UBE2D1 UBE2D2 UBE2D3

9.43e-0611136319712108
Pubmed

Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase.

UBE2D1 UBE2D2 UBE2D3

9.43e-0611136322334663
Pubmed

Human mediator subunit MED26 functions as a docking site for transcription elongation factors.

POLR2A POLR2J TAF1 TAF4B TAF10

1.03e-0573136521729782
Pubmed

Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding.

UBE2D1 UBE2D2 UBE2D3

1.25e-0512136324905733
Pubmed

RECQ5 helicase associates with the C-terminal repeat domain of RNA polymerase II during productive elongation phase of transcription.

POLR2A RECQL5

1.52e-052136220705653
Pubmed

Accumulation of p53 via down-regulation of UBE2D family genes is a critical pathway for cadmium-induced renal toxicity.

UBE2D2 UBE2D4

1.52e-052136226912277
InteractionARK2C interactions

UBE2D1 UBE2D2 UBE2D3 UBE2D4

8.36e-07121324int:ARK2C
InteractionUVSSA interactions

POLR2A UBE2D1 UBE2D2 UBE2D3 UBE2D4

4.12e-06371325int:UVSSA
InteractionRNF150 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2D4

7.85e-06201324int:RNF150
InteractionRNF25 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2D4 ENG

8.81e-06431325int:RNF25
InteractionUBOX5 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2D4

1.41e-05231324int:UBOX5
InteractionTRIM10 interactions

VWA8 UBE2D1 UBE2D2 UBE2D3 UBE2D4

1.53e-05481325int:TRIM10
InteractionRNF216 interactions

FLNB UBE2D1 UBE2D2 UBE2D3 UBE2D4

2.27e-05521325int:RNF216
InteractionPOLM interactions

UBE2D1 UBE2D2 UBE2D3 MTUS1

2.35e-05261324int:POLM
InteractionTRIM43 interactions

VWA8 UBE2D1 UBE2D2 UBE2D3 UBE2D4

2.49e-05531325int:TRIM43
InteractionAREL1 interactions

AREL1 UBE2D1 UBE2D2 UBE2D3

2.75e-05271324int:AREL1
InteractionMYLIP interactions

UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBA6

3.26e-05561325int:MYLIP
InteractionRNF103 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2D4

3.68e-05291324int:RNF103
InteractionCADPS2 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2D4

4.22e-05301324int:CADPS2
InteractionRNF13 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2D4 STARD3

4.57e-05601325int:RNF13
InteractionCARD8 interactions

FLNA VPS72 CEP192 DPP9 MGA

4.57e-05601325int:CARD8
InteractionTRIM62 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2D4

5.48e-05321324int:TRIM62
InteractionBIRC8 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2D4

5.48e-05321324int:BIRC8
InteractionTRIM45 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2D4

6.21e-05331324int:TRIM45
InteractionNUP43 interactions

FLNA DSC1 VPS72 HSDL2 DNAJA2 CCDC168 PBRM1 RECQL5 PARN MGA RPL3 CNOT1 AHNAK2 SEC13

6.23e-0562513214int:NUP43
InteractionCNOT4 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2D4 CNOT1

6.73e-05651325int:CNOT4
InteractionTRIM17 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2D4

7.00e-05341324int:TRIM17
InteractionDTX3 interactions

FLNA FLNB UBE2D1 UBE2D2 UBE2D3 UBE2D4

7.80e-051081326int:DTX3
InteractionDTX1 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2D4

7.87e-05351324int:DTX1
InteractionZNRF1 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2D4

8.80e-05361324int:ZNRF1
InteractionHECW1 interactions

HECW1 UBE2D1 UBE2D2 UBE2D3

9.82e-05371324int:HECW1
InteractionUBTD1 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2D4

1.34e-04401324int:UBTD1
InteractionRNF122 interactions

UBE2D1 UBE2D2 UBE2D3

1.45e-04161323int:RNF122
InteractionHECTD3 interactions

VWA8 CEP192 UBE2D2 UBE2D3 UBE2S RPL3

1.46e-041211326int:HECTD3
InteractionRMND5A interactions

VWA8 ADAR LAP3 PBRM1 RPL3 CNOT1 SEC13

1.51e-041741327int:RMND5A
InteractionBRCA1 interactions

DOCK4 FLNA FLNB POLR2A DNAJA2 POLR2J OLA1 FANCM CLIP1 THOC6 PARP4 UBE2D1 UBE2D2 UBE2D3 ALMS1 ABRAXAS1 RECQL5 RPL3 CNOT1 SEC13

1.81e-04124913220int:BRCA1
InteractionRFWD3 interactions

DNAJA2 UBE2D1 UBE2D2 UBE2D3 UBE2D4

1.81e-04801325int:RFWD3
InteractionGOLGA1 interactions

RGPD1 CEP192 PLEKHG1 ALMS1 MTUS1 FNIP1 AHNAK2

2.06e-041831327int:GOLGA1
InteractionSPATA25 interactions

TAF1 TAF4B TAF10

2.09e-04181323int:SPATA25
InteractionNR3C1 interactions

FNIP2 DOCK3 RASA2 HSDL2 DNAJA2 RGPD1 MUC16 WDR19 PARP4 PBRM1 NXF5 SUGP1 FNIP1 C5 CNOT1 CDH17 AHNAK2

2.13e-0497413217int:NR3C1
InteractionHERC5 interactions

HECW1 RBMS2 UBE2D1 UBE2D2 UBE2D3 UBA6 UBE2S RPL3

2.15e-042451328int:HERC5
InteractionMKRN2 interactions

ATRX RBMS2 CEP192 UBE2D1 UBE2D2 ALMS1 UBE2D4 TAF1 PLEKHH2 CNOT1

2.28e-0438513210int:MKRN2
InteractionMEX3C interactions

ADAR UBE2D2 UBE2D3 UBE2S CNOT1

2.28e-04841325int:MEX3C
InteractionTRIM38 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2D4

2.52e-04471324int:TRIM38
InteractionZNRF2 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2D4

2.52e-04471324int:ZNRF2
InteractionRNF10 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2D4 PIN4

2.69e-04871325int:RNF10
InteractionBFAR interactions

UBE2D1 UBE2D2 UBE2D3 UBE2D4

2.74e-04481324int:BFAR
InteractionPHLDA2 interactions

POLR2A FCHO1 MEN1

2.89e-04201323int:PHLDA2
InteractionTRIM50 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2D4

2.97e-04491324int:TRIM50
InteractionRNF14 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2D4

2.97e-04491324int:RNF14
InteractionTAF8 interactions

TAF1 TAF4B TAF10 ENG

3.21e-04501324int:TAF8
InteractionTAF11 interactions

POLR2A TAF1 TAF4B TAF10

3.46e-04511324int:TAF11
InteractionUHRF2 interactions

ATRX UBE2D1 PBRM1 UBE2D2 UBE2D3 UBE2D4 MGA

3.53e-042001327int:UHRF2
InteractionRING1 interactions

UBE2D1 UBE2D2 UBE2D3 UBE2D4 MTUS1 MGA NOS2

3.64e-042011327int:RING1
Cytoband9q33-q34

TRAF1 C5

5.13e-05413529q33-q34
CytobandEnsembl 112 genes in cytogenetic band chr19p13

CYP4F8 MUC16 FCHO1 C3P1 DPP9 OR10H2 FDX2 SUGP1 FUT6

6.14e-047971359chr19p13
CytobandEnsembl 112 genes in cytogenetic band chr4q21

FRAS1 THAP9 ABRAXAS1 THAP6

6.64e-041331354chr4q21
GeneFamilyUbiquitin conjugating enzymes E2

UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2S

2.21e-0641945102
GeneFamilyRNA polymerase subunits

POLR2J3 POLR2A POLR2J POLR2J2

1.47e-0529944726
GeneFamilyTaste 2 receptors

TAS2R36 TAS2R30 TAS2R46

1.09e-03399431162
GeneFamilyX-linked mental retardation|RNA helicases

ATRX FANCM

1.43e-03119421168
GeneFamilyTHAP domain containing

THAP9 THAP6

1.71e-031294265
GeneFamilyFucosyltransferases|Blood group antigens

FUT10 FUT6

2.01e-0313942434
CoexpressionHALLMARK_MITOTIC_SPINDLE

DOCK4 FLNA FLNB CDC42EP4 RASA2 CEP192 CLIP1 ARHGAP4 ALMS1

9.59e-071991359M5893
CoexpressionGSE2124_CTRL_VS_LYMPHOTOXIN_BETA_TREATED_MLN_DN

FUT10 PSAT1 DDX59 VWA8 DNAAF9 FANCM PCOLCE2 AHNAK2

8.99e-061981358M6190
CoexpressionFOSTER_TOLERANT_MACROPHAGE_DN

FLNB TRAF1 DNAJA2 RGPD1 CEMIP2 PNPT1 AREL1 MTUS1 PRPF4 ENG NOS2

1.64e-0543513511MM1221
ToppCellRV-10._Endothelium_II|RV / Chamber and Cluster_Paper

DOCK4 FLNB ADAMTSL1 RBMS2 RALGAPA2 CEMIP2 PLEKHG1 RBMS3 ENG

8.00e-09193135901c2df9206f1527c578e808978e58196c35e72f5
ToppCellRV-10._Endothelium_II|World / Chamber and Cluster_Paper

DOCK4 FLNB ADAMTSL1 RBMS2 RALGAPA2 CEMIP2 PLEKHG1 LIFR ENG

8.00e-0919313592531266bc57339d4e2b22a88817008e32b8c1598
ToppCellRA-10._Endothelium_II|World / Chamber and Cluster_Paper

CDK17 FLNB ADAMTSL1 RALGAPA2 CEMIP2 PLEKHG1 RBMS3 ENG

1.17e-07189135875c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCellRA-10._Endothelium_II|RA / Chamber and Cluster_Paper

CDK17 FLNB ADAMTSL1 RBMS2 RALGAPA2 CEMIP2 PLEKHG1 ENG

1.17e-071891358c81787a8c662db5d7814c583dd64562857629e81
ToppCellRA-09._Endothelium_I|World / Chamber and Cluster_Paper

DOCK4 CDK17 FLNB RBMS2 RALGAPA2 PLEKHG1 LIFR ENG

1.27e-071911358c8a0c2af119bc34a8f694a7d30642f28002c84b9
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 CDK17 FLNB ADAMTSL1 RBMS2 RALGAPA2 PLEKHG1 ENG

1.49e-071951358818bc18c5834238e5f733cac6fe928ed0788f57d
ToppCellRA-09._Endothelium_I|RA / Chamber and Cluster_Paper

DOCK4 FLNB RBMS2 RALGAPA2 PLEKHG1 LIFR ENG

2.02e-0619213578a1b1c3e83a68ad74f8f4eb00455c9e41aa57cfc
ToppCellLV-10._Endothelium_II|LV / Chamber and Cluster_Paper

FLNB ADAMTSL1 RALGAPA2 CEMIP2 PLEKHG1 RBMS3 ENG

2.16e-061941357b6cc849fa08599bff9839ef382d190cc964e273e
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 CDK17 RALGAPA2 PLEKHG1 HMCN2 MTUS1 ENG

2.24e-061951357d35102f95bb1e419d2df05ff0a01b6c5c923acef
ToppCellCOVID-19-lung-Capillary_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

DOCK4 RBMS2 RALGAPA2 CEMIP2 PLEKHG1 LIFR ENG

2.31e-061961357ac28e9be288af6f00a841aea4ce4b99aed6b4505
ToppCellCOVID-19-lung-Capillary_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

DOCK4 CDK17 RBMS2 RALGAPA2 CEMIP2 PLEKHG1 ENG

2.47e-06198135745419f2804b4be79bae6632e71c54e1af482d115
ToppCellTCGA-Mesothelium-Primary_Tumor-Mesothelioma-Epitheliod-2|TCGA-Mesothelium / Sample_Type by Project: Shred V9

DOCK4 HSDL2 GALNT12 COBL CIPC THAP6

9.47e-061601356d288b0a315f6adc0be4bdc89fa67bf93679a743f
ToppCellfacs-Heart-RA-18m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNB RALGAPA2 CEMIP2 ZFHX2 GJA10 ENG

1.25e-05168135606dc5b2d356d3a9454b10bba6f3b9ead2a0a7d46
ToppCellfacs-Heart-RA-18m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNB RALGAPA2 CEMIP2 ZFHX2 GJA10 ENG

1.25e-0516813561002f058a340763e3d8de0bd1f0547a903526ec6
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D231|Adult / Lineage, Cell type, age group and donor

FNIP2 FRAS1 DSC1 PLEKHG1 LIFR MTUS1

1.34e-051701356269dee5abca9f6aa079f116f0d8f1d198604d9d4
ToppCellmetastatic_Brain-Fibroblasts-Undetermined|Fibroblasts / Location, Cell class and cell subclass

GPD1 DOCK4 FUT10 CAPN7 CNOT1 AHNAK2

1.43e-051721356c3822ff7329c3ac38c68c5c38cd67c390682e2a6
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PER3 RBMS3 PCOLCE2 DSEL MGA CNOT1

1.74e-051781356c87945146b2734141f07b39d268e0d8086ee0364
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FNIP2 FRAS1 SPIRE2 ADAMTSL1 SLC44A5 MTUS1

1.79e-051791356815b959ce8721c5ded70c0ca6e318dafc691746e
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

ATRX PARP4 PBRM1 ALMS1 TAF1 CDH17

2.22e-05186135603db813598b67b1e08f759758a1c2023396921fa
ToppCellLV-10._Endothelium_II|World / Chamber and Cluster_Paper

FLNB ADAMTSL1 RALGAPA2 CEMIP2 PLEKHG1 ENG

2.29e-0518713567876dcb4800c2e54874df3d933efb79307a64a97
ToppCellCOVID-19-lung-Vein_EC|lung / Disease (COVID-19 only), tissue and cell type

FLNB ADAMTSL1 RALGAPA2 CEMIP2 PLEKHG1 LIFR

2.36e-051881356d582b76fc2faac526c9bf97503041129e1a6a211
ToppCellCOVID-19-Heart-EC_(POSTN)|COVID-19 / Disease (COVID-19 only), tissue and cell type

ADAMTSL1 RALGAPA2 CEMIP2 MTUS1 RBMS3 ENG

2.43e-0518913567346c1112e2e155dbd71b6dbc80e680fd262a691
ToppCellControl-Endothelial-VE_Capillary_B|Endothelial / Disease state, Lineage and Cell class

DOCK4 CDC42EP4 RBMS2 CEMIP2 LIFR ENG

2.51e-0519013567f3f419fffe02934b6f27b697f7a6401072491ed
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK3 PARP4 SLC44A5 COBL PLEKHH2 HYDIN

2.58e-051911356d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CLIP1 CEMIP2 LIFR RBMS3 PLEKHH2 ENG

2.58e-05191135608720998aa55131d7377c4c67c4c935865bd7d79
ToppCellEpithelial-club_cell|World / Lineage, Cell type, age group and donor

FNIP2 FRAS1 ADAMTSL1 PLEKHG1 SLC44A5 MTUS1

2.74e-0519313562bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCellPBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

THEMIS DSC1 POLR2J3 MTUS1 DSEL RPL3

2.74e-051931356d371403b51281a6e37652fa8dc1b2dd81d2ab371
ToppCellPBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

THEMIS DSC1 POLR2J3 MTUS1 DSEL RPL3

2.74e-0519313566436d3bfce02d137b76e5c4c8b2fe27974c57c99
ToppCellPBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

THEMIS DSC1 POLR2J3 MTUS1 DSEL RPL3

2.74e-0519313563cde93bbfc1ae6fb586ae6b7aaa6ed8b5eee28a4
ToppCellPBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

THEMIS DSC1 POLR2J3 MTUS1 DSEL RPL3

2.74e-051931356d755dc6de4fbd4d8f5d8a88aac497e7b9e8b89de
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 CDK17 ADAMTSL1 RBMS2 PLEKHG1 ENG

2.74e-0519313561f978e102a029a6beb10913052cd0a20c7253e8e
ToppCellRA|World / Chamber and Cluster_Paper

FRAS1 CEMIP2 RBMS3 UGGT2 C7 ENG

2.82e-05194135608f0afbb68a63150fbe107a5337299081c3f69e4
ToppCellLA-02._Fibroblast_II|World / Chamber and Cluster_Paper

HMCN2 RBMS3 UGGT2 PCOLCE2 C7 PLEKHH2

2.90e-051951356a78b605b49acd8c9d68716266ca269dafcd910b9
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 CDK17 RBMS2 RALGAPA2 PLEKHG1 ENG

2.98e-0519613567cbb19108b4553ef60ef5c230a29de1662c02efe
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 CDK17 RBMS2 RALGAPA2 PLEKHG1 ENG

2.98e-0519613564cd1e6b7a791e11a40b19f971b7011bd11fe6273
ToppCellCV-Moderate-6|CV / Virus stimulation, Condition and Cluster

THEMIS ATRX POLR2J3 POLR2J PBRM1 TAF10

2.98e-0519613567bced0cc2112697593c478fa291b8ed3941fb811
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 CDK17 RBMS2 RALGAPA2 PLEKHG1 ENG

2.98e-051961356d37f714d4fb57e958f3738fdda085560813e5bb5
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 CDK17 ADAMTSL1 RBMS2 PLEKHG1 ENG

2.98e-051961356e224338490691d92c1f70b57112fabdcc92b06a9
ToppCellfacs-Liver-Non-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNB RALGAPA2 CEMIP2 PLEKHG1 LIFR ENG

3.07e-051971356deefb492b5f0e6014144bd465c4a6ae4206e8739
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 CDK17 ADAMTSL1 RBMS2 PLEKHG1 ENG

3.07e-051971356c10dd1aaec01fb662eac83dfde90e3e426665d65
ToppCellfacs-Liver-Non-hepatocytes-3m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNB RALGAPA2 CEMIP2 PLEKHG1 LIFR ENG

3.07e-051971356a6aaa6faea348291023f0bc4b0f83fbc67d91da6
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 CDK17 ADAMTSL1 RBMS2 PLEKHG1 ENG

3.07e-0519713562844dbcd0a673ed81c99920aa45858651a00736d
ToppCellfacs-Liver-Non-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNB RALGAPA2 CEMIP2 PLEKHG1 LIFR ENG

3.16e-051981356f0f1816a0ed3ae8207442602f5cbe4de0382e4b3
ToppCellCOVID-19-lung-Capillary_2|lung / Disease (COVID-19 only), tissue and cell type

CDK17 RALGAPA2 CEMIP2 PLEKHG1 LIFR ENG

3.25e-051991356793ce71b78a68033ef4419ed571e1dd86b40124f
ToppCell367C-Endothelial_cells|367C / Donor, Lineage, Cell class and subclass (all cells)

FLNB RALGAPA2 PLEKHG1 LIFR MTUS1 ENG

3.25e-051991356636ff80938907f137e955388797072ab45289062
ToppCellILEUM-inflamed-(8)_Fibroblast-(8)_Fibroblasts|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

FLNB ATRX LIFR RBMS3 C7 PLEKHH2

3.25e-051991356615f20bf136dfef53b072667cf0e4df6a1017e05
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Ductal_and_Papillary_Carcinoma-1|TCGA-Breast / Sample_Type by Project: Shred V9

DNAJA2 SPRED3 UBE2D3 OCIAD1 PPP1R1C

7.04e-051411355330f944b38c3170dfc79ab033fae7b9ab71e840d
ToppCellmetastatic_Lymph_Node-Fibroblasts-COL13A1+_matrix_FBs|Fibroblasts / Location, Cell class and cell subclass

TRAF1 CDC42EP4 HSDL2 ARHGAP4 C7

7.28e-0514213550e0f8bb956ff89dc98e8fa56f8acac33e01a26dd
ToppCell390C-Myeloid-Macrophage-SPP1+_Macrophage_3|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

FNIP2 TRAF1 C5 C7 CDH17

1.24e-041591355af137688e06a97ff97bb7def54f0dd164d155b11
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FRAS1 ADAMTSL1 MUC16 COBL AHNAK2

1.56e-041671355c042d6cdddd0e1ddef1e3ac6f4fe23151127b0f2
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FRAS1 ADAMTSL1 PPFIBP2 MUC16 AHNAK2

1.56e-0416713557abc785e688a384672d7fb5a62d32538fe7e5a51
ToppCellP15-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TRAF1 FRAS1 ADAMTSL1 GALNT12 WDR19

1.56e-0416713555c3d0763f73628c71c71f9883556bb4f1639f3cc
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FRAS1 ADAMTSL1 PPFIBP2 MUC16 AHNAK2

1.56e-041671355d50311b1f66f143bae4c4cf50e2e9b13c85d6920
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FRAS1 ADAMTSL1 MUC16 COBL AHNAK2

1.56e-041671355351f8de1fbdf742ac74f9099b254d515ab539bb2
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts-COL13A1+_matrix_FBs|Fibroblasts / Location, Cell class and cell subclass

GALNT12 ABRAXAS1 C7 PLEKHH2 RPL3

1.65e-04169135584b898a9fd8ced67c6a501d5cef6416f519902c4
ToppCell343B-Endothelial_cells-Endothelial-D|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

FLNA LIFR C7 ENG RPL3

1.69e-04170135552fdf93c2803fecb2a640ef4e0b257786f3d4cb1
ToppCellControl-Epithelial_cells-ECM-high_epithelial|Control / group, cell type (main and fine annotations)

DOCK4 FLNB PLEKHG1 RBMS3 COBL

1.69e-041701355e2023d66e70983c87dacbd6181d3426488d1fc57
ToppCell343B-Endothelial_cells-Endothelial-D-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

FLNA LIFR C7 ENG RPL3

1.69e-041701355263e98aa1c49493cc262b2608c6582930841cb10
ToppCellTCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-8|TCGA-Liver / Sample_Type by Project: Shred V9

GPD1 VWA8 C3P1 HMCN2 C7

1.74e-041711355c4a919fe3d56ae6df2fcab6686abacc10befc053
ToppCellcellseq2-Epithelial-Epithelial_Glandular-Goblet-Goblet|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CYP2C9 RGPD1 MUC16 FAM83D NOS2

1.74e-04171135525c1979e972c959e1ce4c57804f976f53a247ad7
ToppCellcellseq2-Epithelial-Epithelial_Glandular-Goblet|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CYP2C9 RGPD1 MUC16 FAM83D NOS2

1.74e-041711355fe27bf581c75ef33c2848878e51ed16b275a4c8e
ToppCelldroplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-proliferating_dendritic|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ALMS1 ABRAXAS1 CAPN7 FAM83D TAF4B

1.79e-041721355b043d4f81dced7fb3326043f68474123be47cc5d
ToppCellASK454-Epithelial-Transformed_epithelium|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

FLNB VPS72 PPFIBP2 RBMS2 DSEL

1.79e-0417213553986f0f098ef5e096c8d9ee3d335b8404083701f
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AREL1 UBE2D4 PPP1R1C PCOLCE2 TAF4B

1.84e-04173135523e50492bc673aff9df95d97f0b9be4ce57cbf01
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FRAS1 PPFIBP2 MUC16 AGXT2 AHNAK2

1.84e-04173135530d67738633493d47f06ae452424382f069b6c0a
ToppCelldroplet-Heart-4Chambers-18m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNB PCDHGA11 CEMIP2 PPP1R1C ENG

1.84e-0417313559a04271c51fae34f547db3206f9ff5857686e45c
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 POLR2A ADAR CAPN7 ZFHX2

1.89e-041741355f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCellTuft-tuft-4|World / Class top

FLNB SPIRE2 PLEKHG1 PER3 ZFHX2

1.89e-041741355d6f306ebf66061bf9e9742000bfedce12d277452
ToppCellLPS-IL1RA+antiTNF|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LIFR MTUS1 COBL C7 PLEKHH2

2.04e-041771355b7fee75de7e96924af488a5baa2334711889ae7c
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

CDK17 FLNA LAP3 MEN1 UBE2S

2.04e-04177135584930899eb2978598bc8a351cbcd9e714e46799d
ToppCellP28-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FRAS1 ADAMTSL1 PPFIBP2 MUC16 COBL

2.10e-0417813551e05bc26591fea16e29bcfc5f538dda1dc427f05
ToppCellFetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RBMS2 RALGAPA2 LAP3 PLEKHG1 NOS2

2.21e-041801355d8ef44710a77ad0fc03243428e5e1dc4d41200cb
ToppCellRA-01._Fibroblast_I|World / Chamber and Cluster_Paper

RBMS3 UGGT2 PCOLCE2 C7 ENG

2.27e-0418113552b6ddeb53a79a658e2ba78527ff48c155b20daa6
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FRAS1 PPFIBP2 MUC16 COBL AHNAK2

2.27e-041811355330d4322f4c4373f706273c1f4e218b59051b7fd
ToppCelldroplet-Liver-nan-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RALGAPA2 CEMIP2 PLEKHG1 MTUS1 ENG

2.27e-041811355a53f05c4c47465ee62e353716456bd09ab464b23
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FRAS1 PPFIBP2 MUC16 COBL AHNAK2

2.27e-0418113553f4d5d79c1286614514b0e8134079d6128a2a23e
ToppCellfacs-Lung-nan-3m-Mesenchymal-fibroblast_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK4 RBMS3 PCOLCE2 C7 PLEKHH2

2.32e-041821355c557de6ccd327c46e0a5423cd9936d78e0abae5f
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

FLNB FRAS1 PLEKHG1 SLC44A5 VGLL1

2.32e-041821355215c303df42f13597b2c7a95cb157c6bc7aca9a1
ToppCellfacs-Lung-nan-3m-Mesenchymal-Alveolar_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK4 RBMS3 PCOLCE2 C7 PLEKHH2

2.32e-041821355dbe4b2557cf19e0682ed446f8397d3a1153642f0
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-Alveolar_Mac|Myeloid_cells / Location, Cell class and cell subclass

GPD1 VWA8 RBMS2 GALNT12 PCOLCE2

2.32e-041821355a035d45fd512bee8dac38eb387dbf39f5a8a1fed
ToppCelldroplet-Liver-nan-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RALGAPA2 CEMIP2 PLEKHG1 MTUS1 ENG

2.38e-041831355709a486154b3157427deb3b8886b63ac39ea42dd
ToppCelldroplet-Liver-nan-3m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RALGAPA2 CEMIP2 PLEKHG1 MTUS1 ENG

2.38e-041831355dc06f19f6f80f4c7f13f1f990c1fe0f91ba64ea7
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 CDK17 RBMS2 ENG NOS2

2.38e-041831355dc19857b66dcadbf7c87de91f7b1f4e8ef2857ed
ToppCellHealthy-CD8+_T_naive|Healthy / disease group, cell group and cell class

THEMIS DSC1 MUC16 DSEL RPL3

2.38e-0418313555e7a611cfb8a21106bb07361878ccc77ff251502
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 CDK17 RBMS2 ENG NOS2

2.38e-0418313554759560e5b4f4e5a00e5f933e3451a27c7c4aefe
ToppCellNeuron-Postmitotic-Inhibitory_Neuron-SST-MGE1-3|World / Primary Cells by Cluster

GPD1 CEMIP2 MTUS1 RBMS3 POLR2J2

2.44e-041841355907ba412166bcb0526c5be0b06a76b6bd37c5a35
ToppCellCOVID-19-Endothelial_cells-Arterial_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

RALGAPA2 PLEKHG1 LIFR HMCN2 RBMS3

2.44e-0418413550f19494789f38ab1a420545e15e748ca7eb345c3
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D231|Adult / Lineage, Cell type, age group and donor

ADAMTSL1 HMCN2 RBMS3 C7 PLEKHH2

2.51e-041851355fb6bd7e849ecf4ed9cd9c4e2a946a2d12d62f804
ToppCell3'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_arterial_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SPRED3 LIFR MTUS1 RBMS3 AHNAK2

2.51e-041851355fa94c4a1660967f211ba095606cd0aa37d38e17a
ToppCellControl-Epithelial-Club|Epithelial / Disease state, Lineage and Cell class

ADAMTSL1 PLEKHG1 SLC44A5 RBMS3 TAF4B

2.51e-0418513556814b3c94c7558443c038a227b5c8563d2cfeac4
ToppCelldroplet-Heart-nan-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK4 ATRX CEMIP2 LIFR ENG

2.57e-0418613550ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCellLA-01._Fibroblast_I|World / Chamber and Cluster_Paper

HMCN2 RBMS3 UGGT2 PCOLCE2 PLEKHH2

2.63e-0418713554ea486991f66c29728d127171a07b81404ec0b78
ToppCell3'-Adult-Appendix-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SPRED3 LIFR MTUS1 RBMS3 AHNAK2

2.63e-04187135537d8ee5c8bd6324749e5a2adef1d0482c75da80c
ToppCellControl-Fibroblasts-Alveolar_FB|Control / group, cell type (main and fine annotations)

DOCK4 FRAS1 RBMS3 C7 PLEKHH2

2.63e-04187135592d468dde81125d51daf7abd4703741abe1ab91c
ToppCell3'-Adult-Appendix-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SPRED3 LIFR MTUS1 RBMS3 AHNAK2

2.63e-041871355ec98d5e480b08854dfd0ba6b1dc6610455f90640
ToppCellCOVID-19-Heart-EC_2|Heart / Disease (COVID-19 only), tissue and cell type

CDK17 FLNB PLEKHG1 ARHGAP4 ENG

2.63e-04187135540ffc06a3e3251d9b12da390210d3e045af7537a
ToppCellControl-Endothelial_cells-Arterial_endothelial_cells|Control / group, cell type (main and fine annotations)

FLNB RALGAPA2 LIFR RBMS3 ENG

2.63e-04187135581affaab3fe3e1daea45ada6445e906ddd33950e
ToppCell-Unknown-Endothelial-Myofibroblast| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK3 FUT10 HSDL2 PPFIBP2 MTUS1

2.70e-0418813556468fa95ad0395395301115286f2d8c0df5d3882
ToppCell-Unknown-Endothelial| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK3 FUT10 HSDL2 PPFIBP2 MTUS1

2.70e-0418813557a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell-Unknown| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK3 FUT10 HSDL2 PPFIBP2 MTUS1

2.70e-0418813559cb718bfe1358c6fd842f096e228eb0abb9aefc6
ComputationalGenes in the cancer module 4.

UBE2D1 UBE2D2 UBE2D3 UBE2S

1.71e-0521824MODULE_4
ComputationalGenes in the cancer module 233.

UBE2D1 UBE2D2 UBE2D3 UBE2S

2.07e-0522824MODULE_233
ComputationalGenes in the cancer module 82.

UBE2D1 UBE2D2 UBE2D3 UBE2S

2.98e-0524824MODULE_82
Diseasealcohol and nicotine codependence

RGPD1 PLEKHG1 CAPN7

2.01e-05131243EFO_0004776
DiseasePancreatic Endocrine Carcinoma

ATRX MEN1

5.24e-0531242C1328479
Diseasemyofibrillar myopathy 5 (implicated_via_orthology)

FLNA FLNB

5.24e-0531242DOID:0080096 (implicated_via_orthology)
Diseasedistal muscular dystrophy 4 (implicated_via_orthology)

FLNA FLNB

5.24e-0531242DOID:0111190 (implicated_via_orthology)
Diseaseosteochondrodysplasia (is_implicated_in)

FLNA FLNB LIFR

6.68e-05191243DOID:2256 (is_implicated_in)
DiseaseX-12125 measurement

AGXT2 ALMS1

1.05e-0441242EFO_0800707
DiseaseCis-4-decenoyl carnitine measurement

FNIP2 SLC44A5

1.74e-0451242EFO_0022091
Diseasepulse pressure measurement

FLNB FUT10 TRAF1 CYP2C9 PLEKHG1 PNPT1 AREL1 FNDC1 PBRM1 PPP1R1C SYT4 PCOLCE2 HHIPL1 CNOT1 HYDIN CDH17

2.46e-04139212416EFO_0005763
Diseaseserum galactose-deficient IgA1 measurement

HECW1 GALNT12

2.60e-0461242EFO_0007947
DiseaseX-11787 measurement

CYP2C9 ALMS1

4.82e-0481242EFO_0021258
DiseaseN2,N2-dimethylguanosine measurement

AGXT2 ALMS1

4.82e-0481242EFO_0021125
Diseaseosteoarthritis, spine, body mass index

CLIP1 PER3

4.82e-0481242EFO_0004340, EFO_1000787
Diseaseoctanoylcarnitine measurement

FNIP2 SLC44A5

6.19e-0491242EFO_0021042
Diseaseprimary immunodeficiency disease (is_implicated_in)

FCHO1 DPP9 FNIP1

7.38e-04421243DOID:612 (is_implicated_in)
DiseaseNeuroendocrine Tumors

ATRX MEN1

9.40e-04111242C0206754
DiseaseHamman-Rich syndrome

DPP9 PARN

1.54e-03141242C0085786
Diseasecranial vault morphology measurement

ADAMTSL1 VPS72 PPP1R1C NOS2

1.73e-031211244EFO_0009278
Diseasecancer biomarker measurement

FCHO1 FUT6

1.77e-03151242EFO_0005127
DiseaseN-acetylmethionine measurement

DOCK3 ALMS1

1.77e-03151242EFO_0021427
DiseaseMalignant neoplasm of breast

FLNA FLNB DDX59 VPS72 OLA1 PLEKHD1 ADAR CLIP1 PBRM1 PER3 ABRAXAS1 NOS2

1.93e-03107412412C0006142
Diseasealcoholic liver cirrhosis

SUGP1 TAF4B

2.29e-03171242EFO_1000802
DiseaseGlobal developmental delay

POLR2A PNPT1 TAF1 CNOT1

2.44e-031331244C0557874
Diseasealpha synuclein measurement

PNPT1 RBMS3

2.56e-03181242EFO_0009323
DiseaseUsual Interstitial Pneumonia

DPP9 PARN

2.86e-03191242C4721509
DiseaseHamman-Rich Disease

DPP9 PARN

2.86e-03191242C4721508
Diseaseage-related macular degeneration, COVID-19

DPP9 FUT6 RPL3

3.10e-03691243EFO_0001365, MONDO_0100096
Diseasecitrulline measurement

HMCN2 RBMS3

3.17e-03201242EFO_0009777
DiseaseFamilial Idiopathic Pulmonary Fibrosis

DPP9 PARN

3.17e-03201242C4721952
Diseaseskin hydration measurement

PKD1L1 PLEKHG1

3.49e-03211242EFO_0009586
DiseaseIdiopathic Pulmonary Fibrosis

DPP9 PARN

3.49e-03211242C1800706
Diseasegamma-glutamylglutamine measurement

RBMS2 UBE2D3

3.83e-03221242EFO_0021138

Protein segments in the cluster

PeptideGeneStartEntry
HSLYKPQKGLFHRVP

ABRAXAS1

151

Q6UWZ7
KEHLSPVVTAYFQKP

AGXT2

71

Q9BYV1
IQELAPKYAATHPKT

CDNF

171

Q49AH0
GPPFHLKKYSVAQQC

GJA10

256

Q969M2
KPIVIYKQAFPEGHL

ALMS1

1481

Q8TCU4
KPIVNYKQAFPDGHL

ALMS1

1576

Q8TCU4
KYINYTFPKLSPGHA

C6orf163

291

Q5TEZ5
SFLLHFYTVPIPKTG

ENG

531

P17813
IITHFNGKYIKTPPG

RBMS2

191

Q15434
VIQHFNGKYLKTPPG

RBMS3

196

Q6XE24
HKQPGSKDAIYTIPV

RASA2

641

Q15283
QYHKPASKIPAFLNV

OLA1

76

Q9NTK5
FIPNHLPFKLEKTYG

PCDHGA11

386

Q9Y5H2
YLGSFLSPPKIHVSA

PARN

396

O95453
PDPLTLYHKGIASAK

MEN1

301

O00255
PPLKAGKTRTFYGLH

LAP3

76

P28838
VHTAYSRLPGKPKVY

NOS2

1041

P35228
KFYVHIKPAPARAPA

FCHO1

356

O14526
LKPLFKNTSVGPLYS

MUC16

12266

Q8WXI7
ASVIYLKPKGPHSQE

OR10H2

256

O60403
GQLIAEPFYHLPSKK

PBRM1

401

Q86U86
KPSGKIVYNITLPLH

FRAS1

1496

Q86XX4
YPKSRVLKFSPGVDH

FRAS1

3091

Q86XX4
YPVSPKQKYSHVILG

MGA

921

Q8IWI9
LLPIFAYPHTVGKSV

HHIPL1

461

Q96JK4
PALVGTEKPKYLQHS

MTUS1

106

Q9ULD2
KNYGVLHVTFPLLFP

NLRP11

816

P59045
DPYLKISIQPGKHSI

HECW1

226

Q76N89
KNYHVEVLIPPSISK

HMCN2

2631

Q8NDA2
GLHSLAFKSYKPEIQ

KIAA2026

706

Q5HYC2
LSPGYSQFSLPVQKK

FANCM

1321

Q8IYD8
HNLKKSGYEVPTPIQ

DDX59

216

Q5T1V6
VAPFGYLKIHRLKPS

ADAMTSL1

926

Q8N6G6
LVKYNDKHIPGSPFT

FLNB

1891

O75369
KITRNFYVDGHVPKP

FDX2

171

Q6P4F2
AIHQKVLKYAGHPPF

PER3

321

P56645
FTDPPVKTKFGYHII

PIN4

111

Q9Y237
PRAFKGIQHLPVAYK

JRK

241

O75564
SHFTAPYSVKNKLKP

NXF5

86

Q9H1B4
LPQSYHTPIKDKVFS

OR2T6

261

Q8NHC8
KHFALTFPKPLQRGT

CYLC1

31

P35663
YAQSKPISPKLLSHF

FAM83D

291

Q9H4H8
AKTAQPHPKLLGTIY

HSDL2

41

Q6YN16
SFLHQYTGSFKKPPL

CDK17

56

Q00537
FIGHYIFRPKKLPTT

PCOLCE2

261

Q9UKZ9
TNKSHVPIEAKYIFP

PARP4

646

Q9UKK3
PHLFPSFTKLTNIYK

RALGAPA2

251

Q2PPJ7
PKDQGPTYLLIGSKH

PLEKHH2

891

Q8IVE3
FLAEHKYPTLPGKLS

PPFIBP2

416

Q8ND30
ILSSHPKYGSIPKLI

OCIAD1

66

Q9NX40
ALVAHKYDFKLSLPP

ITPRIPL1

331

Q6GPH6
FKHLDGRQIVVKYPP

DNAJA2

286

O60884
TALTKFLPPKHEYVL

ATRX

1821

P46100
GLHLYFQPTKPVNIK

HYDIN

2996

Q4G0P3
PNVKGIFPANYIHLK

DOCK3

51

Q8IZD9
PNIKGIFPSSYVHLK

DOCK4

51

Q8N1I0
SRHYPVFENPKQGKL

ADAR

986

P55265
GPKIAFYVGLKSPHE

C1QL2

156

Q7Z5L3
FTLPKSKSGISHYPI

C3P1

16

Q6ZMU1
SKSGISHYPISVKVP

C3P1

21

Q6ZMU1
PHYLTKIKLTTPGTH

CAPN7

636

Q9Y6W3
LQPGKKHPTVLFVYG

DPP9

631

Q86TI2
TVSVKYKGQHVPGSP

FLNA

2211

P21333
SPKNNYKLFHKPVIT

FUT10

151

Q6P4F1
ILSYAPALKPFGAKS

FNDC1

396

Q4ZHG4
YKGSTLKIHQIRSPP

FNIP1

141

Q8TF40
KGSTLKIHYIRSPPQ

FNIP2

151

Q9P278
HLNIIVTPKSPYIDK

C5

481

P01031
VTPKSPYIDKITHYN

C5

486

P01031
LTPAFHFNILKPYIK

CYP4F8

151

P98187
QSHPQKPFYTVGEKV

C7

641

P10643
LKHGLTTYKIIPPKS

COBL

701

O75128
PVVPKATYGLKHAES

CDC42EP4

191

Q9H3Q1
PSPFSGNIYHILGKV

DNAAF9

1001

Q5TEA3
VGHVFPKQAPYSRNK

GALNT12

361

Q8IXK2
KFSYLGPDPVHKLLT

AREL1

386

O15033
GPIHLTRSTFKKYVP

CEMIP2

876

Q9UHN6
LKVDVYGRSHKPLPQ

FUT6

216

P51993
LYSILQHKGLVDKFP

GPD1

306

P21695
HSLKFLSPREPFYVK

CEP192

2471

Q8TEP8
DLPNTPHSKAVYKIL

DSC1

381

Q08554
PYFVTPNLHGILIKK

SLC44A5

696

Q8NCS7
YPKTQHKSLLEQFTP

CCDC168

6396

Q8NDH2
PIIDYFPGTHNKLLK

CYP2C9

221

P11712
PHTNTGYVIIKKPLD

CDH17

506

Q12864
PSLYSLKNVPEHLAK

DSEL

1046

Q8IZU8
ISQLILFKKNPYPGS

PKD1L1

1511

Q8TDX9
AIKPYLALKGSVAFP

PMCH

101

P20382
QPKYGLFAPVHKVTK

CLIP1

266

P30622
LFAPVHKVTKIGFPS

CLIP1

271

P30622
IPHYTSLKPSKNFEI

FAM166A

86

Q6J272
VYPHTPTSFKVKDIN

LIFR

431

P42702
FPGSPAIYKLKEHLL

RGPD1

116

P0DJD0
LFAGYKVPHPLEHKI

POLR2J3

56

Q9H1A7
SLIDHPSGQKPNYIK

SEC13

166

P55735
NKTPPYKFVHVLKGV

SYT4

46

Q9H2B2
YPSTHPFILILGNKK

TAS2R30

271

P59541
YPSTHPFILILGNKK

TAS2R36

271

P0DTE0
YPSTHPFILIWGNKK

TAS2R46

271

P59540
KLYVELKSSPQPHLV

TAF4B

306

Q92750
TPALSEYGINVKKPH

TAF10

201

Q12962
DPSKPVHLTAFLGYK

RPL3

36

P39023
VAPVVKKPHIYYGSL

PRPF4

21

O43172
HRPPLKKYSFGALSQ

TAF1

616

P21675
NTYPFHTPVNAKVVK

TAF1

1401

P21675
QSVYTPPTIKGVKHL

PPP1R1C

71

Q8WVI7
INIVHPKLGSYTKIP

PSAT1

121

Q9Y617
TAAYELLHFPKVFPK

ST3GAL6

236

Q9Y274
STKVPFAHKPLLLYN

WDR19

601

Q8NEZ3
PNSKLKGLTFHVFPT

THAP6

16

Q8TBB0
LFTPSPEIVKYTHKL

PNPT1

276

Q8TCS8
PHKYITLPAGTEKQV

ARHGAP4

796

P98171
VPFHGKTFILKTFLP

STARD3

276

Q14849
YGFSLLKVKIPEPHT

AHNAK2

5516

Q8IVF2
ILNSYTKIAPHPGKR

CIPC

156

Q9C0C6
YQKSLKPAPHLFAQL

CNOT1

101

A5YKK6
LFAGYKVPHPLEHKI

POLR2J2

56

Q9GZM3
HVYSLKPKRVGAGFP

RECQL5

646

O94762
GPVKSYSHAKQLPVA

SUGP1

141

Q8IWZ8
NFPKRHFLIPTSYKG

THEMIS

326

Q8N1K5
PYLHGGIAVQVKTPK

UBA6

281

A0AVT1
PFKPPKVAFTTRIYH

UBE2D2

61

P62837
YGQPLLLSVPKHKLT

USP4

601

Q13107
PFYLHDLKVGPKLTL

ZFHX2

1366

Q9C0A1
PSVSLYKIPQGVHLK

THAP9

86

Q9H5L6
LKGPLLPETYSKINH

THAP9

531

Q9H5L6
ETNKYFNIHPKGVIP

PLEKHD1

71

A6NEE1
PSKKFGHIPVYTLGF

SPIRE2

606

Q8WWL2
LKPGLVYNKVNPIFH

SPRED3

66

Q2MJR0
GPYKHISPGDTKVVV

POLR2A

616

P24928
PFKPPKVAFTTRIYH

UBE2D3

61

P61077
KKPVVTFQAHDGPVY

THOC6

66

Q86W42
LFFPLSKLQSPKHAY

TRAF1

386

Q13077
GQSLPPQKKAYLSHL

ZNF862

101

O60290
PASPPKGYFLTKIFH

UBE2S

71

Q16763
ISVGYHGTKPDLIFK

ZNF26

51

P17031
KHSLPLGSYLLKPVQ

PLEKHG1

236

Q9ULL1
EAYKKYITAHGLPPT

VPS72

321

Q15906
LKNYLSPTFKEVIPH

UGGT2

1266

Q9NYU1
PFKPPKVAFTTKIYH

UBE2D4

61

Q9Y2X8
PKGAVLYKTFVHVVP

MRPL27

121

Q9P0M9
LYKTFVHVVPAKPEG

MRPL27

126

Q9P0M9
HKYGIPIGAKPTSVQ

VWA8

1021

A3KMH1
LLFNLPPGSVHYKKL

VGLL1

201

Q99990
LKDPQVLFAGYKVPH

POLR2J

51

P52435
VLFAGYKVPHPLEHK

POLR2J

56

P52435
PFKPPKIAFTTKIYH

UBE2D1

61

P51668