Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	ERBB4 OR11G2 HLA-DRB1 HLA-DRB3 HLA-DRB5 OR52L1 OR5H15 GRIN1 ADGRV1 OR2H1 S1PR3 BDKRB2 LEPR CCKAR OR2M4 OR51E1 ADRB3 OR2AT4 OR51Q1 GPR149 RXFP2 ROS1 FCRL5 OR6T1 IL17RD OR5H1 OR2H2	1.42e-07	1353	130	27	GO:0004888
GeneOntologyMolecularFunction	peptide antigen binding	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 TAP2	1.64e-05	49	130	5	GO:0042605
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR11G2 OR52L1 OR5H15 ADGRV1 OR2H1 S1PR3 BDKRB2 CCKAR OR2M4 OR51E1 ADRB3 OR2AT4 OR51Q1 GPR149 RXFP2 OR6T1 OR5H1 OR2H2	1.72e-05	884	130	18	GO:0004930
GeneOntologyMolecularFunction	MHC class II protein complex binding	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.68e-05	27	130	4	GO:0023026
GeneOntologyMolecularFunction	ABC-type vitamin B12 transporter activity	ABCC1 ABCD4	4.21e-05	2	130	2	GO:0015420
GeneOntologyMolecularFunction	MHC class II receptor activity	HLA-DRB1 HLA-DRB3 HLA-DRB5	4.28e-05	11	130	3	GO:0032395
GeneOntologyMolecularFunction	olfactory receptor activity	OR11G2 OR52L1 OR5H15 OR2H1 OR2M4 OR51E1 OR2AT4 OR51Q1 OR6T1 OR5H1 OR2H2	1.21e-04	431	130	11	GO:0004984
GeneOntologyMolecularFunction	MHC protein complex binding	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	1.44e-04	41	130	4	GO:0023023
GeneOntologyMolecularFunction	peptide binding	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 GRIN1 CCKAR TPP1 GPR149 TAP2	2.40e-04	318	130	9	GO:0042277
GeneOntologyMolecularFunction	fatty acid transmembrane transporter activity	ABCC1 ABCD4 SLC5A8	4.34e-04	23	130	3	GO:0015245
GeneOntologyMolecularFunction	hormone binding	PDE3A LEPR CCKAR ADRB3 RXFP2	5.69e-04	103	130	5	GO:0042562
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNHD1 DNAH1 HOOK1	7.84e-04	28	130	3	GO:0051959
GeneOntologyMolecularFunction	2-acylglycerol O-acyltransferase activity	LPGAT1 DGAT1	1.15e-03	8	130	2	GO:0003846
GeneOntologyMolecularFunction	lipid transmembrane transporter activity	ABCC1 PSG11 ABCD4 SLC5A8	1.32e-03	73	130	4	GO:0170055
GeneOntologyBiologicalProcess	MHC class II protein complex assembly	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.59e-06	16	130	4	GO:0002399
GeneOntologyBiologicalProcess	peptide antigen assembly with MHC class II protein complex	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.59e-06	16	130	4	GO:0002503
GeneOntologyBiologicalProcess	MHC protein complex assembly	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	8.30e-06	21	130	4	GO:0002396
GeneOntologyBiologicalProcess	peptide antigen assembly with MHC protein complex	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	8.30e-06	21	130	4	GO:0002501
GeneOntologyBiologicalProcess	antigen processing and presentation of exogenous peptide antigen	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 TAP2	1.27e-05	48	130	5	GO:0002478
GeneOntologyBiologicalProcess	antigen processing and presentation of exogenous antigen	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 TAP2	3.23e-05	58	130	5	GO:0019884
GeneOntologyBiologicalProcess	antigen processing and presentation of exogenous peptide antigen via MHC class II	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	4.72e-05	32	130	4	GO:0019886
GeneOntologyBiologicalProcess	antigen processing and presentation of peptide antigen via MHC class II	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	7.59e-05	36	130	4	GO:0002495
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR11G2 OR52L1 OR5H15 OR2H1 OR2M4 OR51E1 OR2AT4 OR51Q1 OR6T1 OR5H1 OR2H2	9.33e-05	432	130	11	GO:0050911
GeneOntologyBiologicalProcess	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	9.42e-05	38	130	4	GO:0002504
GeneOntologyBiologicalProcess	myeloid dendritic cell antigen processing and presentation	HLA-DRB1 HLA-DRB3	1.18e-04	3	130	2	GO:0002469
GeneOntologyBiologicalProcess	antigen processing and presentation of peptide antigen	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 TAP2	1.19e-04	76	130	5	GO:0048002
GeneOntologyBiologicalProcess	sensory perception of smell	OR11G2 OR52L1 OR5H15 OR2H1 OR2M4 OR51E1 OR2AT4 OR51Q1 OR6T1 OR5H1 OR2H2	1.78e-04	465	130	11	GO:0007608
GeneOntologyCellularComponent	MHC class II protein complex	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	3.29e-06	17	131	4	GO:0042613
GeneOntologyCellularComponent	endoplasmic reticulum membrane	PIGN MBTPS1 LMF1 DPY19L1 SAMD8 HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 GRIN1 SEC31B GGCX LPIN1 GDPD5 THADA NFE2L1 LPIN2 ABCD4 LPGAT1 TMEM39A TAP2 DGAT1	1.70e-05	1293	131	22	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	PIGN MBTPS1 LMF1 DPY19L1 SAMD8 HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 GRIN1 SEC31B GGCX LPIN1 GDPD5 THADA NFE2L1 LPIN2 ABCD4 LPGAT1 TMEM39A TAP2 DGAT1	1.83e-05	1299	131	22	GO:0098827
GeneOntologyCellularComponent	MHC protein complex	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	1.98e-05	26	131	4	GO:0042611
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	PIGN MBTPS1 LMF1 DPY19L1 SAMD8 HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 GRIN1 SEC31B GGCX LPIN1 GDPD5 THADA NFE2L1 LPIN2 ABCD4 LPGAT1 TMEM39A TAP2 DGAT1	2.53e-05	1327	131	22	GO:0042175
GeneOntologyCellularComponent	inner dynein arm	DNHD1 DNAH1 DNAI7	2.79e-05	10	131	3	GO:0036156
GeneOntologyCellularComponent	ER to Golgi transport vesicle membrane	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 SEC31B	5.07e-05	64	131	5	GO:0012507
GeneOntologyCellularComponent	leading edge membrane	PSD VEZT PSD3 GRIN1 ADGRV1 ITGB1 RASGRP2 PSD4	5.46e-05	210	131	8	GO:0031256
GeneOntologyCellularComponent	lumenal side of endoplasmic reticulum membrane	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	6.63e-05	35	131	4	GO:0098553
GeneOntologyCellularComponent	lumenal side of membrane	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.31e-04	48	131	4	GO:0098576
GeneOntologyCellularComponent	autolysosome membrane	HLA-DRB1 HLA-DRB3	2.32e-04	4	131	2	GO:0120281
GeneOntologyCellularComponent	cell projection membrane	PSD VEZT PSG11 PSD3 GRIN1 ADGRV1 ITGB1 SLC5A8 RASGRP2 PSD4	3.93e-04	431	131	10	GO:0031253
GeneOntologyCellularComponent	axonemal dynein complex	DNHD1 DNAH1 DNAI7	5.00e-04	25	131	3	GO:0005858
GeneOntologyCellularComponent	stereocilia ankle link	VEZT ADGRV1	5.75e-04	6	131	2	GO:0002141
GeneOntologyCellularComponent	stereocilia ankle link complex	VEZT ADGRV1	5.75e-04	6	131	2	GO:0002142
GeneOntologyCellularComponent	stereocilium membrane	VEZT ADGRV1	5.75e-04	6	131	2	GO:0060171
GeneOntologyCellularComponent	cleavage furrow	PSD PSD3 ITGB1 PSD4	5.83e-04	61	131	4	GO:0032154
GeneOntologyCellularComponent	ruffle membrane	PSD PSD3 ITGB1 RASGRP2 PSD4	5.96e-04	108	131	5	GO:0032587
GeneOntologyCellularComponent	COPII-coated ER to Golgi transport vesicle	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 SEC31B	6.48e-04	110	131	5	GO:0030134
GeneOntologyCellularComponent	stereocilia coupling link	VEZT ADGRV1	1.06e-03	8	131	2	GO:0002139
GeneOntologyCellularComponent	clathrin-coated endocytic vesicle membrane	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	1.54e-03	79	131	4	GO:0030669
GeneOntologyCellularComponent	cell division site	PSD PSD3 ITGB1 PSD4	1.61e-03	80	131	4	GO:0032153
GeneOntologyCellularComponent	Golgi membrane	MBTPS1 MGAT4B SAMD8 ASAH2 HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HUWE1 DSEL IL17RD DOP1B	1.94e-03	721	131	12	GO:0000139
GeneOntologyCellularComponent	hemidesmosome	ITGB1 ERBIN	2.07e-03	11	131	2	GO:0030056
Domain	MHC_II_b_N	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	1.54e-07	8	130	4	PD000328
Domain	MHC_II_b_N	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.75e-07	9	130	4	IPR000353
Domain	MHC_II_beta	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.75e-07	9	130	4	SM00921
Domain	MHC_II_beta	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.75e-07	9	130	4	PF00969
Domain	MHC_II_a/b_N	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.13e-06	14	130	4	IPR014745
Domain	-	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.13e-06	14	130	4	3.10.320.10
Domain	GPCR_Rhodpsn_7TM	OR11G2 OR52L1 OR5H15 OR2H1 S1PR3 BDKRB2 CCKAR OR2M4 OR51E1 ADRB3 OR2AT4 OR51Q1 GPR149 RXFP2 OR6T1 OR5H1 OR2H2	4.11e-06	670	130	17	IPR017452
Domain	7tm_1	OR11G2 OR52L1 OR5H15 OR2H1 S1PR3 BDKRB2 CCKAR OR2M4 OR51E1 ADRB3 OR2AT4 OR51Q1 GPR149 RXFP2 OR6T1 OR5H1 OR2H2	4.72e-06	677	130	17	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR11G2 OR52L1 OR5H15 OR2H1 S1PR3 BDKRB2 CCKAR OR2M4 OR51E1 ADRB3 OR2AT4 OR51Q1 GPR149 RXFP2 OR6T1 OR5H1 OR2H2	5.51e-06	685	130	17	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR11G2 OR52L1 OR5H15 OR2H1 S1PR3 BDKRB2 CCKAR OR2M4 OR51E1 ADRB3 OR2AT4 OR51Q1 GPR149 RXFP2 OR6T1 OR5H1 OR2H2	6.18e-06	691	130	17	PS50262
Domain	GPCR_Rhodpsn	OR11G2 OR52L1 OR5H15 OR2H1 S1PR3 BDKRB2 CCKAR OR2M4 OR51E1 ADRB3 OR2AT4 OR51Q1 GPR149 RXFP2 OR6T1 OR5H1 OR2H2	6.30e-06	692	130	17	IPR000276
Domain	PH_dom-spectrin-type	PSD PSD3 PSD4	2.68e-05	9	130	3	IPR001605
Domain	Olfact_rcpt	OR11G2 OR52L1 OR5H15 OR2H1 OR2M4 OR51E1 OR2AT4 OR51Q1 OR6T1 OR5H1 OR2H2	9.65e-05	393	130	11	IPR000725
Domain	MHC_I/II-like_Ag-recog	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	1.38e-04	38	130	4	IPR011162
Domain	-	PSD PSD3 PSD4	1.41e-04	15	130	3	1.10.1000.11
Domain	Sec7	PSD PSD3 PSD4	1.41e-04	15	130	3	PF01369
Domain	Sec7_alpha_orthog	PSD PSD3 PSD4	1.41e-04	15	130	3	IPR023394
Domain	Lipin_N	LPIN1 LPIN2	1.44e-04	3	130	2	IPR007651
Domain	Lipin_mid	LPIN1 LPIN2	1.44e-04	3	130	2	IPR031703
Domain	Lipin_N	LPIN1 LPIN2	1.44e-04	3	130	2	PF04571
Domain	Lipin_mid	LPIN1 LPIN2	1.44e-04	3	130	2	PF16876
Domain	SEC7	PSD PSD3 PSD4	1.73e-04	16	130	3	PS50190
Domain	Sec7	PSD PSD3 PSD4	1.73e-04	16	130	3	SM00222
Domain	Sec7_dom	PSD PSD3 PSD4	1.73e-04	16	130	3	IPR000904
Domain	C1-set	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	5.41e-04	54	130	4	PF07654
Domain	IGc1	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	6.22e-04	56	130	4	SM00407
Domain	LNS2	LPIN1 LPIN2	7.08e-04	6	130	2	IPR013209
Domain	LNS2	LPIN1 LPIN2	7.08e-04	6	130	2	SM00775
Domain	LNS2	LPIN1 LPIN2	7.08e-04	6	130	2	PF08235
Domain	LNS2/PITP	LPIN1 LPIN2	7.08e-04	6	130	2	IPR031315
Domain	Ig/MHC_CS	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	7.11e-04	58	130	4	IPR003006
Domain	Ig_C1-set	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	7.11e-04	58	130	4	IPR003597
Domain	IG_MHC	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	8.08e-04	60	130	4	PS00290
Domain	ABC_TM1F	ABCC1 ABCD4 TAP2	9.50e-04	28	130	3	PS50929
Domain	ABC1_TM_dom	ABCC1 ABCD4 TAP2	9.50e-04	28	130	3	IPR011527
Domain	-	COL20A1 ITGB1 MDN1 CPNE4	1.77e-03	74	130	4	3.40.50.410
Domain	Phosphodiest/P_Trfase	PIGN ENPP5	2.09e-03	10	130	2	IPR002591
Domain	Phosphodiest	PIGN ENPP5	2.09e-03	10	130	2	PF01663
Domain	-	MBTPS1 TPP1	2.54e-03	11	130	2	3.40.50.200
Domain	Peptidase_S8/S53_dom	MBTPS1 TPP1	2.54e-03	11	130	2	IPR000209
Domain	Peptidase_S8	MBTPS1 TPP1	2.54e-03	11	130	2	PF00082
Domain	VWFA	COL20A1 ITGB1 MDN1 CPNE4	2.58e-03	82	130	4	PS50234
Domain	VWA	COL20A1 ITGB1 MDN1 CPNE4	2.81e-03	84	130	4	SM00327
Domain	ABC_transporter_CS	ABCC1 ABCD4 TAP2	3.10e-03	42	130	3	IPR017871
Domain	AAA	ABCC1 PEX1 MDN1 ABCD4 TAP2	3.36e-03	144	130	5	SM00382
Domain	AAA+_ATPase	ABCC1 PEX1 MDN1 ABCD4 TAP2	3.36e-03	144	130	5	IPR003593
Domain	Dynein_HC_stalk	DNHD1 DNAH1	4.14e-03	14	130	2	IPR024743
Domain	Dynein_heavy_dom-2	DNHD1 DNAH1	4.14e-03	14	130	2	IPR013602
Domain	DHC_N2	DNHD1 DNAH1	4.14e-03	14	130	2	PF08393
Domain	ATPase_dyneun-rel_AAA	DNAH1 MDN1	4.14e-03	14	130	2	IPR011704
Domain	MT	DNHD1 DNAH1	4.14e-03	14	130	2	PF12777
Domain	AAA_5	DNAH1 MDN1	4.14e-03	14	130	2	PF07728
Domain	ABC_tran	ABCC1 ABCD4 TAP2	4.53e-03	48	130	3	PF00005
Domain	ABC_TRANSPORTER_2	ABCC1 ABCD4 TAP2	4.53e-03	48	130	3	PS50893
Domain	DHC_fam	DNHD1 DNAH1	4.76e-03	15	130	2	IPR026983
Domain	Dynein_heavy	DNHD1 DNAH1	4.76e-03	15	130	2	PF03028
Domain	Dynein_heavy_dom	DNHD1 DNAH1	4.76e-03	15	130	2	IPR004273
Domain	ABC_TRANSPORTER_1	ABCC1 ABCD4 TAP2	4.81e-03	49	130	3	PS00211
Domain	VWF_A	COL20A1 ITGB1 MDN1 CPNE4	5.07e-03	99	130	4	IPR002035
Domain	ABC_transporter-like	ABCC1 ABCD4 TAP2	5.09e-03	50	130	3	IPR003439
Domain	bZIP_2	FOSB NFE2L1	6.11e-03	17	130	2	PF07716
Domain	-	MXRA5 COL20A1 PSG11 HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 LEPR ROS1 FCRL5 CD96	6.64e-03	663	130	11	2.60.40.10
Domain	LRR_8	MXRA5 LRTM1 ERBIN ELFN1 RXFP2	6.93e-03	171	130	5	PF13855
Pathway	BIOCARTA_IL5_PATHWAY	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 IL1B	1.71e-08	13	97	5	M18928
Pathway	BIOCARTA_MHC_PATHWAY	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 TAP2	2.65e-08	14	97	5	M22023
Pathway	BIOCARTA_BBCELL_PATHWAY	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	6.70e-07	11	97	4	M22030
Pathway	BIOCARTA_EOSINOPHILS_PATHWAY	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	6.70e-07	11	97	4	M22048
Pathway	BIOCARTA_TCRA_PATHWAY	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.00e-06	14	97	4	M10765
Pathway	BIOCARTA_BLYMPHOCYTE_PATHWAY	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.00e-06	14	97	4	M1473
Pathway	KEGG_MEDICUS_PATHOGEN_HTLV_1_TAX_TO_NFY_MEDIATED_TRANSCRIPTION	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.71e-06	15	97	4	M47588
Pathway	KEGG_MEDICUS_REFERENCE_ANTIGEN_PROCESSING_AND_PRESENTATION_BY_MHC_CLASS_II_MOLECULES	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.71e-06	15	97	4	M47604
Pathway	BIOCARTA_ASBCELL_PATHWAY	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.71e-06	15	97	4	M7298
Pathway	KEGG_GRAFT_VERSUS_HOST_DISEASE	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 IL1B	8.56e-06	41	97	5	M13519
Pathway	KEGG_LEISHMANIA_INFECTION	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 ITGB1 IL1B	9.84e-06	72	97	6	M3126
Pathway	KEGG_TYPE_I_DIABETES_MELLITUS	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 IL1B	1.09e-05	43	97	5	M12617
Pathway	BIOCARTA_CSK_PATHWAY	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	1.40e-05	22	97	4	M6327
Pathway	BIOCARTA_CTLA4_PATHWAY	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	1.40e-05	22	97	4	M1467
Pathway	BIOCARTA_TH1TH2_PATHWAY	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	1.69e-05	23	97	4	M6705
Pathway	REACTOME_PD_1_SIGNALING	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	3.80e-05	28	97	4	M18810
Pathway	BIOCARTA_INFLAM_PATHWAY	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	4.38e-05	29	97	4	M6910
Pathway	KEGG_ASTHMA	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	5.03e-05	30	97	4	M13950
Pathway	REACTOME_TRIGLYCERIDE_BIOSYNTHESIS	LPIN1 LPIN2 DGAT1	6.64e-05	12	97	3	MM15447
Pathway	REACTOME_TRIGLYCERIDE_BIOSYNTHESIS	LPIN1 LPIN2 DGAT1	1.09e-04	14	97	3	M619
Pathway	KEGG_ALLOGRAFT_REJECTION	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	1.17e-04	37	97	4	M18615
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR11G2 OR52L1 OR5H15 OR2H1 OR2M4 OR51E1 OR2AT4 OR51Q1 OR6T1 OR5H1 OR2H2	1.35e-04	417	97	11	M4072
Pathway	REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	1.44e-04	39	97	4	M16523
Pathway	WP_CONGENITAL_GENERALIZED_LIPODYSTROPHY	LPIN1 LPIN2 DGAT1	2.39e-04	18	97	3	M42546
Pathway	KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	3.25e-04	48	97	4	M615
Pathway	KEGG_HEMATOPOIETIC_CELL_LINEAGE	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 IL1B	3.29e-04	87	97	5	M6856
Pathway	WP_ETHER_LIPID_BIOSYNTHESIS	PEX1 LPIN1 LPIN2	3.31e-04	20	97	3	M46451
Pathway	KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 TAP2	3.47e-04	88	97	5	M16004
Pathway	KEGG_AUTOIMMUNE_THYROID_DISEASE	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	4.43e-04	52	97	4	M13103
Pathway	REACTOME_TRIGLYCERIDE_METABOLISM	LPIN1 LPIN2 DGAT1	5.06e-04	23	97	3	MM15575
Pathway	REACTOME_INTERFERON_GAMMA_SIGNALING	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 SMAD7	5.70e-04	98	97	5	M965
Pathway	REACTOME_TRANSPORT_OF_RCBL_WITHIN_THE_BODY	ABCC1 ABCD4	9.62e-04	7	97	2	MM15703
Pathway	WP_PATHWAYS_AFFECTED_IN_ADENOID_CYSTIC_CARCINOMA	ATRX ERBIN KANSL1 IL17RD	1.03e-03	65	97	4	M39682
Pathway	REACTOME_TRANSPORT_OF_RCBL_WITHIN_THE_BODY	ABCC1 ABCD4	1.28e-03	8	97	2	M45025
Pathway	KEGG_VIRAL_MYOCARDITIS	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	1.36e-03	70	97	4	M12294
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR11G2 OR52L1 OR2H1 OR2M4 OR51E1 OR2AT4 OR51Q1 OR6T1 OR2H2	1.42e-03	389	97	9	M14091
Pubmed	Allelic variation in the DR subregion of the human major histocompatibility complex.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	1.98e-10	4	132	4	3476943
Pubmed	Next-Generation Sequencing Reveals That HLA-DRB3, -DRB4, and -DRB5 May Be Associated With Islet Autoantibodies and Risk for Childhood Type 1 Diabetes.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	1.98e-10	4	132	4	26740600
Pubmed	HLA-DRB alleles and systemic lupus erythematosus in Jamaicans.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	1.98e-10	4	132	4	12144077
Pubmed	Associations of human leukocyte antigen DRB with resistance or susceptibility to HIV-1 infection in the Pumwani Sex Worker Cohort.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	1.98e-10	4	132	4	18520346
Pubmed	Antinuclear antibodies and HLA class II alleles in Jamaican patients with systemic lupus erythematosus.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	9.88e-10	5	132	4	17910142
Pubmed	Major histocompatibility complex class II molecules promote human immunodeficiency virus type 1 assembly and budding to late endosomal/multivesicular body compartments.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	9.88e-10	5	132	4	16973583
Pubmed	Genetic variability in HIV-1 gp120 affects interactions with HLA molecules and T cell receptor.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	9.88e-10	5	132	4	1970352
Pubmed	Cross-reactive cytotoxic T lymphocytes induced by V3 loop synthetic peptides from different strains of human immunodeficiency virus type 1.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	9.88e-10	5	132	4	7645219
Pubmed	A comparison of HLA-DR and -DQ allele and haplotype frequencies in Trinidadian populations of African, South Asian, and mixed ancestry.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	9.88e-10	5	132	4	12392858
Pubmed	HLA-DQ8 and the HLA-DQ8-DR4 haplotype are positively associated with the hevein-specific IgE immune response in health care workers with latex allergy.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	9.88e-10	5	132	4	12209103
Pubmed	HLA-DQA is associated with abdominal aortic aneurysms in the Belgian population.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	9.88e-10	5	132	4	17182961
Pubmed	NY-ESO-1 119-143 is a promiscuous major histocompatibility complex class II T-helper epitope recognized by Th1- and Th2-type tumor-reactive CD4+ T cells.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	9.88e-10	5	132	4	11782380
Pubmed	Expansion of monocytic myeloid-derived suppressor cells dampens T cell function in HIV-1-seropositive individuals.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	9.88e-10	5	132	4	23152536
Pubmed	HLA-DR-restricted peptides identified in the Nef protein can induce HIV type 1-specific IL-2/IFN-gamma-secreting CD4+ and CD4+ /CD8+ T cells in humans after lipopeptide vaccination.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	9.88e-10	5	132	4	17411376
Pubmed	Productive human immunodeficiency virus type 1 assembly takes place at the plasma membrane.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	9.88e-10	5	132	4	17507489
Pubmed	Competition of HLA-DR and a beta 2 domain peptide for HIV envelope glycoprotein gp120 binding to CD4.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	9.88e-10	5	132	4	7734415
Pubmed	Visual hallucinations and HLA class II antigens in cortical dementia.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	9.88e-10	5	132	4	20606439
Pubmed	HLA-DR and DQB1 gene polymorphism in the North-western Colombian population.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	9.88e-10	5	132	4	12144632
Pubmed	HIV-1 gag polyprotein rescues HLA-DR intracellular transport in a human CD4+ cell line.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	9.88e-10	5	132	4	12202216
Pubmed	HIV-1 Nef impairs the dynamic of DC/NK crosstalk: different outcome of CD56(dim) and CD56(bright) NK cell subsets.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 IL1B	1.42e-09	14	132	5	17431094
Pubmed	Association of immune responses to mycobacterium tuberculosis peptide antigens with host genetic factors.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.96e-09	6	132	4	17153701
Pubmed	MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.96e-09	6	132	4	18305173
Pubmed	HLA-B, -DRB1/3/4/5, and -DQB1 gene polymorphisms in human immunodeficiency virus-related Kaposi's sarcoma.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.96e-09	6	132	4	15902698
Pubmed	HLA risk markers for chronic myelogenous leukemia in Eastern Canada.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.96e-09	6	132	4	19235017
Pubmed	A comparison of molecular HLA-DR and DQ allele profiles forming DR51-, DR52-, and DR53-related haplotypes in five ethnic Thai populations from mainland southeast Asia.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.96e-09	6	132	4	11082517
Pubmed	Complete coding sequences and haplotypic associations of HLA-B0707, -B1524, -B4405, -B4802, -DRB10409, -DRB10411, -DRB11115, -DRB11305, and the novel allele -DRB1*0709. Group-specific amplification of cDNA from DRB1 alleles associated to DRB3 and DRB4.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.96e-09	6	132	4	15896200
Pubmed	HLA class II DNA typing in a large series of European patients with systemic lupus erythematosus: correlations with clinical and autoantibody subsets.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.96e-09	6	132	4	11997714
Pubmed	HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.96e-09	6	132	4	14508706
Pubmed	Anti-cofactor autoantibodies in systemic lupus erythematosus: prevalence, clinical and HLA class II associations.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	6.88e-09	7	132	4	18569076
Pubmed	The HIV core protein p24 inhibits interferon-gamma-induced increase of HLA-DR and cytochrome b heavy chain mRNA levels in the human monocyte-like cell line THP1.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	6.88e-09	7	132	4	1905983
Pubmed	Human macrophages accumulate HIV-1 particles in MHC II compartments.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	6.88e-09	7	132	4	12230470
Pubmed	[Human leukocyte antigen genes to genetic predisposition in diffuse panbronchiolitis].	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	6.88e-09	7	132	4	18846964
Pubmed	The impact of anti-HY responses on outcome in current and subsequent pregnancies of patients with recurrent pregnancy losses.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	6.88e-09	7	132	4	20307907
Pubmed	Association of HY-restricting HLA class II alleles with pregnancy outcome in patients with recurrent miscarriage subsequent to a firstborn boy.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	1.37e-08	8	132	4	19223392
Pubmed	Correlation between HLA and pityriasis rosea susceptibility in Brazilian blacks.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	1.37e-08	8	132	4	16405603
Pubmed	HLA-A, B, Cw, DRB1, DRB3/4/5, DQB1 in German patients suffering from rapidly progressive periodontitis (RPP) and adult periodontitis (AP).	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	1.37e-08	8	132	4	12296785
Pubmed	Human leukocyte antigen class I and class II allele frequencies and HIV-1 infection associations in a Chinese cohort.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	1.37e-08	8	132	4	17106278
Pubmed	Human plasmacytoid dendritic cells efficiently capture HIV-1 envelope glycoproteins via CD4 for antigen presentation.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	1.37e-08	8	132	4	23729440
Pubmed	Fusion of ubiquitin to HIV gag impairs human monocyte-derived dendritic cell maturation and reduces ability to induce gag T cell responses.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.46e-08	9	132	4	24505475
Pubmed	Major histocompatibility complex class-II molecules promote targeting of human immunodeficiency virus type 1 virions in late endosomes by enhancing internalization of nascent particles from the plasma membrane.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.46e-08	9	132	4	23170932
Pubmed	Differential effects of R5 and X4 human immunodeficiency virus type 1 infection on CD4+ cell proliferation and activation.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	4.09e-08	10	132	4	15784911
Pubmed	Roles of HLA-B, HLA-C and HLA-DPA1 incompatibilities in the outcome of unrelated stem-cell transplantation.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	4.09e-08	10	132	4	12956878
Pubmed	HIV-gp 160-induced T cell-dependent B cell differentiation. Role of T cell-B cell activation molecule and IL-6.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	4.09e-08	10	132	4	8450224
Pubmed	HLA-DR genotypes influence age at disease onset in children and juveniles with type 1 diabetes mellitus.	HLA-DRB1 HLA-DRB3 HLA-DRB4	5.34e-08	3	132	3	20371654
Pubmed	Association of HLA-DR3 and HLA-DR4 with sinonasal polyposis in Mexican Mestizos.	HLA-DRB1 HLA-DRB3 HLA-DRB4	5.34e-08	3	132	3	16815190
Pubmed	Influence of MHC class II genotype on outcome of infection with hepatitis C virus. The HENCORE group. Hepatitis C European Network for Cooperative Research.	HLA-DRB1 HLA-DRB3 HLA-DRB5	5.34e-08	3	132	3	10609818
Pubmed	Recent origin of HLA-DRB1 alleles and implications for human evolution.	HLA-DRB1 HLA-DRB4 HLA-DRB5	5.34e-08	3	132	3	9500545
Pubmed	A novel DRB1*09 allelic sequence in the Jing ethnic minority of China.	HLA-DRB1 HLA-DRB4 HLA-DRB5	5.34e-08	3	132	3	12121280
Pubmed	HLA-DR allele frequencies in Mexican mestizos with autoimmune liver diseases including overlap syndromes.	HLA-DRB1 HLA-DRB4 HLA-DRB5	5.34e-08	3	132	3	19811438
Pubmed	Diversity associated with the second expressed HLA-DRB locus in the human population.	HLA-DRB3 HLA-DRB4 HLA-DRB5	5.34e-08	3	132	3	9162096
Pubmed	Polymorphism of human Ia antigens generated by reciprocal intergenic exchange between two DR beta loci.	HLA-DRB1 HLA-DRB4 HLA-DRB5	5.34e-08	3	132	3	3099214
Pubmed	HLA-DR beta-chain polymorphism. Second domain polymorphism reflects evolutionary relatedness of alleles and may explain public serologic epitopes.	HLA-DRB1 HLA-DRB3 HLA-DRB5	5.34e-08	3	132	3	2471740
Pubmed	No gender differences in the frequencies of HLA-DRB3/B4/B5 heterozygotes in newborns and adults in Koreans.	HLA-DRB3 HLA-DRB4 HLA-DRB5	5.34e-08	3	132	3	22531795
Pubmed	A novel HLA-DRB109 allele, HLA-DRB1090103*, isolated from the Han population of Guangdong, China.	HLA-DRB1 HLA-DRB4 HLA-DRB5	5.34e-08	3	132	3	15730527
Pubmed	[Association of hemorrhagic fever with renal syndrome and HLA-DRB allele polymorphisms in Han nationality, Hubei province].	HLA-DRB1 HLA-DRB4 HLA-DRB5	5.34e-08	3	132	3	20193583
Pubmed	Re-evaluation of DRB10702: evidence for only one allele, DRB10701, encoding the beta chain of the HLA-DR7 antigen.	HLA-DRB1 HLA-DRB3 HLA-DRB5	5.34e-08	3	132	3	8016840
Pubmed	Binding domain regulation of MHC class II molecule assembly, trafficking, fate, and function.	HLA-DRB1 HLA-DRB3 HLA-DRB4	5.34e-08	3	132	3	8775462
Pubmed	Identification of a novel HLA-DRB109 allele, DRB10904, in the Korean population, by sequence-based typing.	HLA-DRB1 HLA-DRB4 HLA-DRB5	5.34e-08	3	132	3	16441501
Pubmed	Complete cDNA sequences of the HLA-DRB10402 and DRB111041 alleles.	HLA-DRB1 HLA-DRB4 HLA-DRB5	5.34e-08	3	132	3	12358860
Pubmed	Polymorphism in the regulatory region of HLA-DRB genes correlating with haplotype evolution.	HLA-DRB1 HLA-DRB3 HLA-DRB5	5.34e-08	3	132	3	8462990
Pubmed	Polymorphism of HLA-DR beta chains in DR4, -7, and -9 haplotypes: implications for the mechanisms of allelic variation.	HLA-DRB1 HLA-DRB3 HLA-DRB5	5.34e-08	3	132	3	3466180
Pubmed	Mhc-DRB diversity of the chimpanzee (Pan troglodytes).	HLA-DRB1 HLA-DRB4 HLA-DRB5	5.34e-08	3	132	3	1428007
Pubmed	Direct sequencing of SSP-PCR-amplified cDNA to identify new alleles in the DR52-associated DRB1 group: identification of DRB11115, DRB11117 and DRB1*1319.	HLA-DRB1 HLA-DRB4 HLA-DRB5	5.34e-08	3	132	3	7652736
Pubmed	Allelic diversity is generated by intraexon sequence exchange at the DRB1 locus of primates.	HLA-DRB1 HLA-DRB4 HLA-DRB5	5.34e-08	3	132	3	2023919
Pubmed	Shared class II MHC polymorphisms between humans and chimpanzees.	HLA-DRB1 HLA-DRB4 HLA-DRB5	5.34e-08	3	132	3	2511168
Pubmed	A male-specific increase in the HLA-DRB4 (DR53) frequency in high-risk and relapsed childhood ALL.	HLA-DRB1 HLA-DRB3 HLA-DRB4	5.34e-08	3	132	3	12008082
Pubmed	Therapeutic immunization with HIV-1 Tat reduces immune activation and loss of regulatory T-cells and improves immune function in subjects on HAART.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	6.41e-08	11	132	4	21085635
Pubmed	Intracellular overexpression of HIV-1 Nef impairs differentiation and maturation of monocytic precursors towards dendritic cells.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	6.41e-08	11	132	4	22808111
Pubmed	HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	1.93e-07	14	132	4	7512597
Pubmed	Interaction of CD4 with HLA class II antigens and HIV gp120.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	1.93e-07	14	132	4	1869305
Pubmed	Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice.	LEPR LPIN1 LPIN2	2.13e-07	4	132	3	19136718
Pubmed	HLA class II alleles in systemic sclerosis patients with anti-RNA polymerase I/III antibody: associations with subunit reactivities.	HLA-DRB1 HLA-DRB3 HLA-DRB4	2.13e-07	4	132	3	14677183
Pubmed	Human leukocyte antigen association in idiopathic thrombotic thrombocytopenic purpura: evidence for an immunogenetic link.	HLA-DRB1 HLA-DRB3 HLA-DRB4	2.13e-07	4	132	3	19922436
Pubmed	Association of HLA-DR and -DQ genes with narcolepsy in Koreans: comparison with two control groups, randomly selected subjects and DRB11501-DQB10602--positive subjects.	HLA-DRB1 HLA-DRB3 HLA-DRB4	2.13e-07	4	132	3	17002906
Pubmed	Analysis of DR beta and DQ beta chain cDNA clones from a DR7 haplotype.	HLA-DRB1 HLA-DRB4 HLA-DRB5	2.13e-07	4	132	3	3020127
Pubmed	HLA DR B104, 07-restricted epitopes on Keratin 17 for autoreactive T cells in psoriasis.	HLA-DRB1 HLA-DRB3 HLA-DRB4	2.13e-07	4	132	3	15795121
Pubmed	Strategy for identifying dendritic cell-processed CD4+ T cell epitopes from the HIV gag p24 protein.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.62e-07	15	132	4	22860026
Pubmed	The enhanced immune response to the HIV gp160/LAMP chimeric gene product targeted to the lysosome membrane protein trafficking pathway.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.62e-07	15	132	4	9079699
Pubmed	HIV-1 envelope protein is expressed on the surface of infected cells before its processing and presentation to class II-restricted T lymphocytes.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.62e-07	15	132	4	8376762
Pubmed	Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.62e-07	15	132	4	8168144
Pubmed	Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.62e-07	15	132	4	7602119
Pubmed	HIV-gp120 can block CD4-class II MHC-mediated adhesion.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.62e-07	15	132	4	1967269
Pubmed	AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. Therapeutic implications.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.62e-07	15	132	4	3489470
Pubmed	Efficient incorporation of HLA class II onto human immunodeficiency virus type 1 requires envelope glycoprotein packaging.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	2.62e-07	15	132	4	10729169
Pubmed	Inhibition of CD4+ T cell function by the HIV envelope protein, gp120.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	3.48e-07	16	132	4	2846691
Pubmed	Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	3.48e-07	16	132	4	2543930
Pubmed	Human immunodeficiency virus type 1 Vpu protein interacts with CD74 and modulates major histocompatibility complex class II presentation.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	3.48e-07	16	132	4	17959659
Pubmed	Tat protein induces self-perpetuating permissivity for productive HIV-1 infection.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	3.48e-07	16	132	4	9223324
Pubmed	Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	3.48e-07	16	132	4	1978941
Pubmed	Loading dendritic cells with PLA-p24 nanoparticles or MVA expressing HIV genes induces HIV-1-specific T cell responses.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	4.54e-07	17	132	4	25240755
Pubmed	HLA class II amino acid epitopes as susceptibility markers of sarcoidosis.	HLA-DRB1 HLA-DRB3 HLA-DRB5	5.31e-07	5	132	3	17559577
Pubmed	Association between psoriasis vulgaris and MHC-DRB, -DQB genes as a contribution to disease diagnosis.	HLA-DRB1 HLA-DRB3 HLA-DRB4	5.31e-07	5	132	3	15908298
Pubmed	The role of HLA molecules in susceptibility to chronic rheumatic heart disease.	HLA-DRB1 HLA-DRB3 HLA-DRB5	5.31e-07	5	132	3	16426242
Pubmed	EFA6 activates Arf6 and participates in its targeting to the Flemming body during cytokinesis.	PSD PSD3 PSD4	5.31e-07	5	132	3	23603394
Pubmed	HLA-DRB4 as a genetic risk factor for Churg-Strauss syndrome.	HLA-DRB1 HLA-DRB3 HLA-DRB4	5.31e-07	5	132	3	17763415
Pubmed	Association of HLA-DR, -DQ, and vitamin D receptor alleles and haplotypes with tuberculosis in the Venda of South Africa.	HLA-DRB1 HLA-DRB3 HLA-DRB5	5.31e-07	5	132	3	16916662
Pubmed	HIV-1 Nef promotes endocytosis of cell surface MHC class II molecules via a constitutive pathway.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	5.82e-07	18	132	4	19620308
Pubmed	Reciprocal modulation of transcriptional activities between HIV-1 Tat and MHC class II transactivator CIITA.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	5.82e-07	18	132	4	11118314
Pubmed	Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	5.82e-07	18	132	4	10661406
Pubmed	HIV-1 gp120 modulates the immunological function and expression of accessory and co-stimulatory molecules of monocyte-derived dendritic cells.	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	9.16e-07	20	132	4	12427289
Cytoband	6p21.3	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 TAP2 OR2H2	9.07e-05	250	132	6	6p21.3
Cytoband	11p15.4	DNHD1 UBQLNL OR52L1 OR51E1 OR51Q1	2.95e-04	200	132	5	11p15.4
Cytoband	Ensembl 112 genes in cytogenetic band chr3q11	CLDND1 OR5H15 OR5H1	5.18e-04	54	132	3	chr3q11
GeneFamily	C1-set domain containing	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	6.59e-05	42	94	4	591
GeneFamily	Histocompatibility complex\|C1-set domain containing	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	7.93e-05	44	94	4	588
GeneFamily	Lipins	LPIN1 LPIN2	8.00e-05	3	94	2	1043
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	HAUS6 ATRX FOSB AOAH RALGAPB HECTD4 CLDND1 FRYL HUWE1 BIRC6 ERBIN LPIN1 KANSL1 MAP4K1 TPP1 LPIN2 LPGAT1 TAP2 CD96 TOP2B RASGRP2 SMAD7 PSD4	1.13e-06	1492	130	23	M40023
Coexpression	SOBOLEV_PBMC_PANDEMRIX_AGE_18_64YO_1DY_UP	HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5	3.24e-06	21	130	4	M41167
CoexpressionAtlas	Myeloid Cells, DC.8+.Sp, CD11b CD11c CD45 CD8a CD4, Spleen, avg-2	DPY19L1 FOSB HLA-DRB1 SLC22A23 ARHGAP5 IFITM3 SERPINB2 ENPP5 ARHGAP28 TMEM39A IL1B	2.07e-05	412	119	11	GSM538260_500
CoexpressionAtlas	DevelopingKidney_e15.5_cortic collect duct_emap-28132_top-relative-expression-ranked_1000	PIGN MBTPS1 ATRX DPY19L1 VEZT VEPH1 RALGAPB PEX1 SSBP1 HUWE1 BIRC6 KANSL1 ROS1 TOP2B DOP1B	2.84e-05	774	119	15	gudmap_developingKidney_e15.5_cortic collect duct_1000
CoexpressionAtlas	Myeloid Cells, DC.11cloSer.SI, CD45+ MHCII+ CD11c-lo CD11b+, Small Intestine, avg-5	FOSB HLA-DRB1 AOAH IFITM3 IL1B	2.97e-05	64	119	5	GSM854280_100
CoexpressionAtlas	gudmap_RNAseq_p2_CD2APMEISWT_2500_K4	PDE3A FOSB HLA-DRB1 ITGB1 S1PR3 NR2F1 GGT7 LPIN1 OR51E1 IFITM3 CPNE4 TAP2 PAQR7 RASGRP2 SMAD7	7.39e-05	842	119	15	gudmap_RNAseq_p2_CD2APMEISWT_2500_K4
CoexpressionAtlas	Myeloid Cells, DC.8+.Sp, CD11b CD45 CD4 CD11c CD8a, Spleen, avg-1	DPY19L1 FOSB HLA-DRB1 SLC22A23 ARHGAP5 IFITM3 SERPINB2 ENPP5 ARHGAP28 IL1B	8.12e-05	397	119	10	GSM605827_500
CoexpressionAtlas	Myeloid Cells, DC.8+.Sp, CD11b CD4 CD45 CD11c CD8a, Spleen, avg-2	DPY19L1 FOSB HLA-DRB1 SLC22A23 ARHGAP5 IFITM3 SERPINB2 ARHGAP28 TMEM39A IL1B	9.96e-05	407	119	10	GSM538258_500
CoexpressionAtlas	DevelopingKidney_e15.5_Ureteral Smooth Musc_emap-28812_top-relative-expression-ranked_1000	PIGN MBTPS1 PDE3A PSD ATRX DPY19L1 SSBP1 HUWE1 S1PR3 LEPR KANSL1 ARHGAP28 TMEM26 TOP2B	1.08e-04	772	119	14	gudmap_developingKidney_e15.5_Ureteral Smooth Musc_1000
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PDE3A MXRA5 ELFN1 GPR149 ARHGAP28 DSEL	1.06e-06	181	130	7	154d5e586cab25155c6d06dfe6ae01203b88e0fb
ToppCell	droplet-Marrow-nan-3m-Hematologic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATRX FOSB ITGB1 ERBIN CD96 TOP2B SMAD7	1.10e-06	182	130	7	e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCell	droplet-Marrow-nan-3m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATRX FOSB ITGB1 ERBIN CD96 TOP2B SMAD7	1.10e-06	182	130	7	1710eab3037a87609d21838be2d2d29c3bc36651
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PDE3A ELFN1 GPR149 ARHGAP28 SLC5A8 DSEL	1.36e-06	188	130	7	6ee3f8f94ea7bdf652c9575fc65bff08070093a4
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PDE3A ELFN1 GPR149 ARHGAP28 SLC5A8 DSEL	1.36e-06	188	130	7	c66fccdfe68760b8c3efca77e3c25966dc9a8a5f
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	DIP2B ATRX FRYL ADGRV1 HUWE1 BIRC6 HOOK1	1.62e-06	193	130	7	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Epithelial\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL20A1 AOAH CCKAR SERPINB2 SLC38A3 XPOT	7.10e-06	158	130	6	12661763d1c309106801cb710c04cd2b62d16cba
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Epithelial-epithelial_cell_of_thymus\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL20A1 AOAH CCKAR SERPINB2 SLC38A3 XPOT	7.10e-06	158	130	6	e7db50d6dfaf7280a73a0d5b5aa4f43ea2762d72
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Epithelial-TECs\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL20A1 AOAH CCKAR SERPINB2 SLC38A3 XPOT	7.10e-06	158	130	6	0792c39e6fc0745095af7812de2d50949540d60f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A NR2F1 HEPH C1orf94 RASGRP2 OR2H2	7.36e-06	159	130	6	e812cbde59188924c6277c3feadf1a9592fa62a4
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A NR2F1 HEPH C1orf94 RASGRP2 OR2H2	7.36e-06	159	130	6	2607b562903228274fbd96168ba826782fab0b53
ToppCell	Control\|World / group, cell type (main and fine annotations)	ERBB4 FOSB SLC22A23 VEPH1 ADGRV1 ROS1	1.01e-05	168	130	6	a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A ATRX ITGB1 ERBIN ARHGAP5 TOP2B	1.31e-05	176	130	6	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	CV-Severe-7\|Severe / Virus stimulation, Condition and Cluster	PIGN MBTPS1 TTLL5 HUWE1 LPIN1 KANSL1	1.36e-05	177	130	6	82fdd6185b368f54f03de389427cbe3071d21a99
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 ELFN1 GPR149 ARHGAP28 SLC5A8 DSEL	1.40e-05	178	130	6	3c973aac16988e88f5677d3d695dd772ccfd6570
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PDE3A ELFN1 GPR149 SLC5A8 DSEL	1.45e-05	179	130	6	01302505816f272243659e20d751b61a198a2fc0
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-SMC_prolif\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PDE3A MXRA5 ITGB1 S1PR3 OR51E1 RASGRP2	1.49e-05	180	130	6	64956a85c404a2ea7e4eaf6f95ebcc52c198b7cc
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PDE3A ELFN1 GPR149 SLC5A8 DSEL	1.54e-05	181	130	6	35bcdcd2651149692e5b150e887c0f450c81d2d4
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-4_VIP_DSEL\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PDE3A ELFN1 GPR149 SLC5A8 DSEL	1.54e-05	181	130	6	70eff83dd85691e977972c660731394d2fcf5cdf
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PDE3A ELFN1 GPR149 SLC5A8 DSEL	1.59e-05	182	130	6	3d7a8d2ee2137b098248597058974ef5ae09c19e
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PDE3A ELFN1 GPR149 ARHGAP28 SLC5A8	1.59e-05	182	130	6	420a8fd30543e37a66ba0786215d056d308660d0
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PDE3A ELFN1 GPR149 SLC5A8 DSEL	1.69e-05	184	130	6	32473dbdb2de66391157c5814ef34e790806e4f2
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SZT2 COL20A1 SLC22A23 GGT7 SERPINB2 ENPP5	1.69e-05	184	130	6	e33bb572af9dfd11127105f1ac99bc958a7cafbb
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PDE3A ELFN1 GPR149 ARHGAP28 SLC5A8	1.85e-05	187	130	6	ae2ee6f8e5c37cb88a67f3e742cf86e57657bfaf
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SZT2 RNASEH2A ASAH2 TSPY26P ADRB3 DOP1B	1.85e-05	187	130	6	3699d5e71d779da922920aa3160895db187bf81b
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SZT2 RNASEH2A ASAH2 TSPY26P ADRB3 DOP1B	1.85e-05	187	130	6	033ba52c0c2f9978784947098fa697368ae44834
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ITGB1 S1PR3 LEPR NR2F1 TMEM26 RASGRP2	2.02e-05	190	130	6	1004e89d99c9d46c78b7d3532d8d4aadb81a96fd
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ITGB1 S1PR3 NR2F1 IFITM3 TMEM26 RASGRP2	2.02e-05	190	130	6	106862ef44fcaa0971c3ba0147d13eb08015ca77
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ITGB1 S1PR3 LEPR NR2F1 TMEM26 RASGRP2	2.02e-05	190	130	6	10b02c62e72bfea9767e3e751011436925da823e
ToppCell	COVID-19-Epithelial_cells-Airway_goblet\|COVID-19 / group, cell type (main and fine annotations)	ERBB4 BPIFB1 ADGRV1 BDKRB2 FER1L6 CATSPERB	2.02e-05	190	130	6	51ca9ef4df3220487152fcf684147730637c7cc1
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATRX ITGB1 ERBIN ARHGAP5 HOOK1 TOP2B	2.09e-05	191	130	6	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATRX ITGB1 ERBIN ARHGAP5 HOOK1 TOP2B	2.09e-05	191	130	6	09db184cb90fe282a14474d7217068c58092c6f8
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATRX ITGB1 ERBIN ARHGAP5 HOOK1 TOP2B	2.09e-05	191	130	6	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PDE3A ELFN1 GPR149 ARHGAP28 SLC5A8	2.15e-05	192	130	6	3abee376c37c3646da33ac381aa63d50a01607a6
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PDE3A ELFN1 GPR149 SLC5A8 DSEL	2.15e-05	192	130	6	025fac36b862f9ca7f96fb4a1946c44ba7cbc382
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PDE3A ELFN1 GPR149 SLC5A8 DSEL	2.15e-05	192	130	6	6a252e298f8a454623fa9c1c893a7a45a886d694
ToppCell	wk_20-22-Hematologic_Lymphocytic-B-CD5-_Mature_B\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	HLA-DRB1 HLA-DRB5 MAP4K1 FCRL5 RASGRP2 DOP1B	2.34e-05	195	130	6	fe3f978820a63c26a537d97e69f7999dd60bb0ea
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_pericyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PDE3A MXRA5 ITGB1 S1PR3 NR2F1 OR51E1	2.41e-05	196	130	6	cb61757646653f89faba503cb5d99e5dd5197b4c
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_pericyte-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PDE3A MXRA5 ITGB1 S1PR3 NR2F1 OR51E1	2.41e-05	196	130	6	44e2df1b61e3819eae7e482bef0a733afe852d67
ToppCell	control-Myeloid-Non-resident_Macrophage\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	FOSB AOAH ERBIN IFITM3 LPIN2 IL1B	2.48e-05	197	130	6	df2fe36cb96e2565a9d21c24cb4e451e8befd4be
ToppCell	ILEUM-non-inflamed-(8)_Fibroblast-(8)_Pericytes\|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	PDE3A FOSB S1PR3 NR2F1 OR51E1 RASGRP2	2.48e-05	197	130	6	608328608cef82adc867a449216839622253d486
ToppCell	facs-Tongue-nan-3m-Epithelial-basal_cell_of_epidermis\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MBTPS1 ATRX ITGB1 ERBIN ARHGAP5 TOP2B	2.55e-05	198	130	6	22559b161e67b49fe8028bfaf861e069063599f5
ToppCell	critical-Epithelial-FOXN4+\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DPY19L1 RNASEH2A BPIFB1 HOOK1 FANCI SLC5A8	2.55e-05	198	130	6	6b160b3d6a2c1b1641c2c7dcec1a7ef38411fec9
ToppCell	facs-Tongue-nan-3m-Epithelial-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATRX HUWE1 ITGB1 ERBIN ARHGAP5 TOP2B	2.63e-05	199	130	6	8d50e1ee58710d896c0204937331d9f4dcd38de0
ToppCell	15-Airway-Immune\|Airway / Age, Tissue, Lineage and Cell class	HLA-DRB1 HLA-DRB5 AOAH MAP4K1 IL1B CD96	2.63e-05	199	130	6	a737061703af06cfa1acdf95f77b9d42b3cd7c33
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_2-TYR-L2-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ERBB4 PDE3A ELFN1 GPR149 SLC5A8 DSEL	2.70e-05	200	130	6	04954fbe1e2264077228bb582c9a5897a70e6da2
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_2-SERPINF1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ERBB4 PDE3A ELFN1 GPR149 SLC5A8 DSEL	2.70e-05	200	130	6	c4e08cf539c12bb7c61be6d44b4f074bb460f526
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ERBB4 PDE3A ELFN1 GPR149 SLC5A8 DSEL	2.70e-05	200	130	6	913487e065dd580c9cbcbb3c3fc76a8d446f8856
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_2-TYR\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ERBB4 PDE3A ELFN1 GPR149 SLC5A8 DSEL	2.70e-05	200	130	6	bfdafb024a7b20d46837b2e6480dd4929253cd62
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_2-SERPINF1-L2-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ERBB4 PDE3A ELFN1 GPR149 SLC5A8 DSEL	2.70e-05	200	130	6	f922f9f223cbfed71b8e3115b16b51dc4d7b66b8
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ERBB4 PDE3A ELFN1 GPR149 ARHGAP28 SLC5A8	2.70e-05	200	130	6	75649534a98bc738fca62d071de0978dc61eb24f
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Rbp4-Inhibitory_Neuron.Gad1Gad2_Sst.Rbp4_(Interneuron,_OLM2_(CA1_enriched?))\|Hippocampus / BrainAtlas - Mouse McCarroll V32	FER1L6 RXFP2 TMEM26 PSD4	7.65e-05	77	130	4	9a29879348b32b6c2302820f75fd55efba39aae8
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Rbp4-Inhibitory_Neuron.Gad1Gad2_Sst.Rbp4_(Interneuron,_OLM2_(CA1_enriched?))-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	FER1L6 RXFP2 TMEM26 PSD4	7.65e-05	77	130	4	c5262a0d2040b2c580601e5a8d1ec626a0c7b560
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Rbp4\|Hippocampus / BrainAtlas - Mouse McCarroll V32	FER1L6 RXFP2 TMEM26 PSD4	7.65e-05	77	130	4	3763b55e5ce44b844da661e9024c9f2c847ea26f
ToppCell	BL-critical-LOC-Epithelial-FOXN4+\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PDE3A RNASEH2A BPIFB1 FER1L6 FAM171A2	1.07e-04	160	130	5	3f737451d5713deed20061aa72a9ef77a9a2bc06
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Kcne4\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ERBB4 PDE3A FOSB ELFN1 RASGRP2	1.10e-04	161	130	5	be77e99faf653480c166305df3a4e93db76f0dcb
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma\|TCGA-Brain / Sample_Type by Project: Shred V9	SAMD8 ADGRV1 LPIN1 MDN1 FAM168A	1.10e-04	161	130	5	347edb0de10850b7d16c40945751033289289c9b
ToppCell	Club_cells-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	MXRA5 FOSB BPIFB1 NR2F1 FER1L6	1.10e-04	161	130	5	342f5c61d37df61b35c18f5d258043a8f5cef629
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	HAUS6 SLC22A23 PEX1 FRYL CD96	1.10e-04	161	130	5	5fba13f0aa5002f7eefe219e2c6a07e163f1a50d
ToppCell	facs-Marrow-T_cells-18m-Lymphocytic-Klrb1a/b/c(-)_NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DRP2 MMP8 CD96 DGAT1 DOP1B	1.23e-04	165	130	5	eeb58d4db64ad37dc6b441eab22b05c24862e1a9
ToppCell	droplet-Kidney-nan-18m-Epithelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A S1PR3 NR2F1 ARHGAP28 DNAI7	1.38e-04	169	130	5	87116c33c5ca8cb1862e103e5607b1df4d264569
ToppCell	cellseq2-Epithelial-Epithelial_Airway-Secretory/RAS\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	HAUS6 SLC22A23 BPIFB1 GGCX XPOT	1.42e-04	170	130	5	b62f7184e78e9672ea88e361654f604f9df2dc5f
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-2_VIP_RPL41P3\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PDE3A S1PR3 ELFN1 ARHGAP28	1.42e-04	170	130	5	31e3f57673c99f4d8ef30faa9c40e5f7f5bf6460
ToppCell	cellseq2-Epithelial-Epithelial_Airway-Secretory/RAS-Secretory\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	HAUS6 SLC22A23 BPIFB1 GGCX XPOT	1.42e-04	170	130	5	00fe77bca9c28762212c498f9c49e14cb1492cca
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ABCC1 OR11G2 DNAH1 ARHGAP5 LPIN2	1.42e-04	170	130	5	adb625124832b0786a590e8f75b61e7263a1e0d4
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_ACHE\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PDE3A GPR149 ARHGAP28 SLC5A8	1.42e-04	170	130	5	36dbbdb13f69307afd2122ff051b2980850c1f00
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PDE3A ELFN1 GPR149 SLC5A8	1.46e-04	171	130	5	a5634b76476b8b2488a706bbab5141f7bd94631f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-4_VIP_DSEL\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PDE3A GPR149 SLC5A8 SLC38A3	1.46e-04	171	130	5	2c7d73f1386ddd172839734c68ed3859a90f80f8
ToppCell	368C-Myeloid-Dendritic-pDC\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	LMF1 GDPD5 MAP4K1 DSEL DOP1B	1.46e-04	171	130	5	714a0b0d0c9886fef64170cf53eb64f0d8a47280
ToppCell	3'-GW_trimst-2-SmallIntestine-Hematopoietic-B_cells-Immature_B\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HLA-DRB1 HLA-DRB5 FCRL5 RASGRP2 DOP1B	1.50e-04	172	130	5	0bcb960c5ab0d3cbbdf6235b6f28327ea60ba3e3
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Microglia/Mac\|metastatic_Lymph_Node / Location, Cell class and cell subclass	DNHD1 ZNF862 FOSB BPIFB1 DNAH1	1.50e-04	172	130	5	f673a2e697b46e7cfa4186cb3fb2b98e3c83703e
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-5_VIP_KCNJ2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 MXRA5 ELFN1 ARHGAP28 DSEL	1.58e-04	174	130	5	fdadac1eaab2c4a67e4832f0901df22e893add6a
ToppCell	facs-Heart-LV-24m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	S1PR3 NR2F1 ELFN1 DNAI7 RASGRP2	1.58e-04	174	130	5	a0a059bb2a64d7011e206db2ebcdf3eb655a925a
ToppCell	facs-Heart-LV-24m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	S1PR3 NR2F1 ELFN1 DNAI7 RASGRP2	1.58e-04	174	130	5	7cd6f9103133f8d7b90f9ff4b3b0b078cf554542
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PDE3A ELFN1 GPR149 SLC5A8	1.63e-04	175	130	5	e78bf0c33a741bb97e987e41ac33da9e623a08ec
ToppCell	Adult-Endothelial-endothelial_cell_of_artery-D175\|Adult / Lineage, Cell type, age group and donor	PDE3A LEPR HEPH GDPD5 ELFN1	1.63e-04	175	130	5	0a65ddfa8c2e8efb5b5338cf07661cb78157a23c
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOSB LPGAT1 DNAI7 IL1B TMEM26	1.63e-04	175	130	5	cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DIP2B PSD THADA MDN1 MAP4K1	1.67e-04	176	130	5	6b4afd2c9268172063fe5832896bea15e862579e
ToppCell	facs-Spleen-nan-18m-Lymphocytic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGB1 LPIN1 CD96 PAQR7 DOP1B	1.67e-04	176	130	5	a23d484aff5ad094333b2feae9106ca219514711
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	OR51E1 SLC5A8 CPNE4 DNAI7 SLC38A3	1.67e-04	176	130	5	2e1003dc373b14d27f0464d980453fdcfc1005f0
ToppCell	CV-Severe-7\|CV / Virus stimulation, Condition and Cluster	PIGN MBTPS1 TTLL5 HUWE1 LPIN1	1.67e-04	176	130	5	3de0c7d77210049e5616db21eed1490a17a5ec2d
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PDE3A ELFN1 GPR149 DSEL	1.71e-04	177	130	5	85e270b4a0b0da77ffe5987a099e827c02a4adf3
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 ELFN1 GPR149 ARHGAP28 SLC5A8	1.71e-04	177	130	5	84116796ca4c7007508c0f1a68a1135c7b922278
ToppCell	facs-Heart-RV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC25A33 S1PR3 NR2F1 MDN1 RASGRP2	1.71e-04	177	130	5	7c3d46ebd7e8726be6871aa9763e281fc0ec6ac8
ToppCell	facs-Heart-RV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC25A33 S1PR3 NR2F1 MDN1 RASGRP2	1.71e-04	177	130	5	e7b1f3092e6b8d0d580f82648035f5ad12be6961
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PDE3A ELFN1 GPR149 SLC5A8	1.76e-04	178	130	5	2a36475c260088f69f3b8c282d910e5eaa5c5c2d
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-CD141+_DCs\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	HLA-DRB1 HLA-DRB5 ADRB3 MAP4K1 TAP2	1.81e-04	179	130	5	99894067e2c2a3ed53abdc5434410c3172693496
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Hematopoietic-Myeloid-Macrophages\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HLA-DRB1 HLA-DRB5 AOAH MAP4K1 IL1B	1.81e-04	179	130	5	ae9d90a4eac2cfa545a764df84914c5801544278
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADGRV1 OR51E1 SLC5A8 DNAI7 SLC38A3	1.81e-04	179	130	5	8ce5000088b727783a0619baa16a2cd036d21f54
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ITGB1 S1PR3 LEPR NR2F1 RASGRP2	1.81e-04	179	130	5	56db12467b445f2b8ef92af50779eeab10413eb2
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-6_VIP_RGS16\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PDE3A ELFN1 GPR149 SLC5A8	1.81e-04	179	130	5	5bf191bdc0c32bce83ab5c38f0616e209e420e55
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TTLL5 PSD3 PHEX ARHGAP5 THADA	1.85e-04	180	130	5	a682a5d55c612709c9ee9fa4289d6f8bef7fe1af
ToppCell	Control-Epithelial_cells-AT2\|Control / group, cell type (main and fine annotations)	ERBB4 VEPH1 ADGRV1 ROS1 SLC5A8	1.85e-04	180	130	5	198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell	facs-Spleen-nan-18m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGB1 LPIN1 CD96 PAQR7 DOP1B	1.85e-04	180	130	5	407fd8f61a757626e082b6e2eefd3a33276e6b71
ToppCell	3'-GW_trimst-2-LargeIntestine-Hematopoietic-B_cells-Immature_B\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HLA-DRB1 HLA-DRB5 MAP4K1 FCRL5 RASGRP2	1.90e-04	181	130	5	51836cdc66e42f04ed6a3c167cd6a3a67428c9f7
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PDE3A GPR149 ARHGAP28 SLC5A8	1.90e-04	181	130	5	062f00736eed96e4f4327615d093558dd7d82b20
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A FRYL SEC31B NFE2L1 SMAD7	1.90e-04	181	130	5	4ea02344e1996f264dd5e14f3b19c8782ce41699
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L3_VIP_CBLN1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PDE3A GPR149 ARHGAP28 SLC5A8	1.90e-04	181	130	5	7846c7b33d1b89364c5a704edaa86520db731c89
ToppCell	18-Distal-Immune-Hematopoietic,_B_Cells\|Distal / Age, Tissue, Lineage and Cell class	HLA-DRB1 HLA-DRB5 FCRL5 IL1B RASGRP2	1.95e-04	182	130	5	cd0b9f0a25147ec3bc1e32d698511d1c3b33891f
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Pericyte-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PDE3A MXRA5 ITGB1 S1PR3 IFITM3	1.95e-04	182	130	5	fc4a5bf784705efe7965ce43ac23c2a8e602e90a
Disease	aspirin-induced respiratory disease (is_implicated_in)	HLA-DRB1 HLA-DRB3 HLA-DRB4 TAP2	1.09e-07	11	128	4	DOID:0080822 (is_implicated_in)
Disease	pancreatitis (implicated_via_orthology)	BDKRB2 LEPR IL1B	6.57e-06	9	128	3	DOID:4989 (implicated_via_orthology)
Disease	forced expiratory volume, body mass index	DIS3L2 HLA-DRB1 HECTD4	1.28e-05	11	128	3	EFO_0004314, EFO_0004340
Disease	islet cell tumor (is_marker_for)	ATRX CDK4	1.87e-05	2	128	2	DOID:1799 (is_marker_for)
Disease	Hantavirus hemorrhagic fever with renal syndrome (is_implicated_in)	HLA-DRB1 HLA-DRB5	1.87e-05	2	128	2	DOID:11266 (is_implicated_in)
Disease	myoglobinuria (implicated_via_orthology)	LPIN1 LPIN2	5.59e-05	3	128	2	DOID:0080108 (implicated_via_orthology)
Disease	acute disseminated encephalomyelitis (is_implicated_in)	HLA-DRB1 HLA-DRB5	5.59e-05	3	128	2	DOID:639 (is_implicated_in)
Disease	non-alcoholic fatty liver disease (is_implicated_in)	LEPR ADRB3 IL1B	6.20e-05	18	128	3	DOID:0080208 (is_implicated_in)
Disease	chronic obstructive pulmonary disease (is_implicated_in)	ABCC1 BDKRB2 LEPR IL1B	1.65e-04	63	128	4	DOID:3083 (is_implicated_in)
Disease	Allergic Reaction	HLA-DRB1 HLA-DRB4 HLA-DRB5 IL1B	1.65e-04	63	128	4	C1527304
Disease	Hypersensitivity	HLA-DRB1 HLA-DRB4 HLA-DRB5 IL1B	1.75e-04	64	128	4	C0020517
Disease	hepatocyte nuclear factor 4-alpha measurement	HLA-DRB1 HLA-DRB5	1.85e-04	5	128	2	EFO_0801672
Disease	body mass index, vital capacity	DIS3L2 HLA-DRB1	2.77e-04	6	128	2	EFO_0004312, EFO_0004340
Disease	extranodal nasal NK/T cell lymphoma	HLA-DRB1 HLA-DRB3	2.77e-04	6	128	2	MONDO_0019472
Disease	multiple sclerosis (is_implicated_in)	HLA-DRB1 HLA-DRB3 IL1B TAP2	2.92e-04	73	128	4	DOID:2377 (is_implicated_in)
Disease	cervix uteri carcinoma in situ (is_implicated_in)	HLA-DRB1 IL1B	3.87e-04	7	128	2	DOID:8991 (is_implicated_in)
Disease	pancreatic cancer (biomarker_via_orthology)	CCKAR CDK4	3.87e-04	7	128	2	DOID:1793 (biomarker_via_orthology)
Disease	bullous pemphigoid	HLA-DRB1 HLA-DRB5 LPIN2	4.32e-04	34	128	3	EFO_0007187
Disease	interleukin-21 measurement	HLA-DRB1 HLA-DRB5	5.14e-04	8	128	2	EFO_0801724
Disease	tongue squamous cell carcinoma (is_marker_for)	ERBB4 FOSB FANCI	5.56e-04	37	128	3	DOID:0050865 (is_marker_for)
Disease	Graves' disease (is_implicated_in)	HLA-DRB1 HLA-DRB3 IL1B	6.50e-04	39	128	3	DOID:12361 (is_implicated_in)
Disease	Epstein Barr virus nuclear antigen 1 IgG measurement	HLA-DRB1 HLA-DRB5	6.59e-04	9	128	2	EFO_0007790
Disease	5-acetylamino-6-formylamino-3-methyluracil measurement	PSD3 SLC38A3	6.59e-04	9	128	2	EFO_0800950
Disease	central nervous system non-hodgkin lymphoma	HLA-DRB1 HLA-DRB5	6.59e-04	9	128	2	MONDO_0044887
Disease	HLA class II histocompatibility antigen, DQ alpha 2 chain measurement	HLA-DRB1 HLA-DRB5	6.59e-04	9	128	2	EFO_0801686
Disease	obesity (is_implicated_in)	LEPR CCKAR ADRB3 CDK4	6.75e-04	91	128	4	DOID:9970 (is_implicated_in)
Disease	obsolete_red blood cell distribution width	DIP2B ABCC1 ASAH2 SLC22A23 AOAH HECTD4 BIRC6 OR2M4 KANSL1 HOOK1 NFE2L1 FANCI LPIN2 PUS1 SMAD7	7.56e-04	1347	128	15	EFO_0005192
Disease	pulmonary tuberculosis (is_implicated_in)	HLA-DRB1 IL1B TAP2	8.09e-04	42	128	3	DOID:2957 (is_implicated_in)
Disease	CCL19 measurement	HLA-DRB1 HLA-DRB5	8.21e-04	10	128	2	EFO_0009415
Disease	Cryptorchidism	ATRX RXFP2	8.21e-04	10	128	2	C0010417
Disease	Adenoid Cystic Carcinoma	ATRX ERBIN KANSL1 IL17RD	9.60e-04	100	128	4	C0010606
Disease	fibrinogen measurement, tissue plasminogen activator measurement	DIP2B HECTD4 LEPR	9.90e-04	45	128	3	EFO_0004623, EFO_0004791
Disease	fibrinogen measurement, plasminogen activator inhibitor 1 measurement	DIP2B HECTD4 LEPR	9.90e-04	45	128	3	EFO_0004623, EFO_0004792
Disease	pancreatic cancer (is_marker_for)	CCKAR IL1B CDK4 SMAD7	9.97e-04	101	128	4	DOID:1793 (is_marker_for)
Disease	cocaine use measurement	PSD3 RXFP2	1.00e-03	11	128	2	EFO_0010553
Disease	gallbladder neoplasm	ERBB4 CCKAR	1.00e-03	11	128	2	C0016978
Disease	5-acetylamino-6-amino-3-methyluracil measurement	PSD3 SLC38A3	1.00e-03	11	128	2	EFO_0800951
Disease	vascular dementia (is_marker_for)	GRIN1 IL1B	1.00e-03	11	128	2	DOID:8725 (is_marker_for)
Disease	Malignant neoplasm of gallbladder	ERBB4 CCKAR	1.00e-03	11	128	2	C0153452
Disease	chronic kidney disease (implicated_via_orthology)	LEPR IL1B	1.20e-03	12	128	2	DOID:784 (implicated_via_orthology)
Disease	N-acetylputrescine measurement	PSD3 SLC38A3	1.20e-03	12	128	2	EFO_0800127
Disease	Trigeminal Neuralgia	GRIN1 IL1B	1.20e-03	12	128	2	C0040997
Disease	Secondary Trigeminal Neuralgia	GRIN1 IL1B	1.20e-03	12	128	2	C0393787
Disease	Trigeminal Neuralgia, Idiopathic	GRIN1 IL1B	1.20e-03	12	128	2	C0393786
Disease	anti-Epstein Barr virus antibody measurement	HLA-DRB1 HLA-DRB5	1.20e-03	12	128	2	EFO_0009273
Disease	non-alcoholic steatohepatitis	LEPR C1orf94	1.20e-03	12	128	2	EFO_1001249
Disease	Reactive Hyperemia	BDKRB2 IL1B	1.41e-03	13	128	2	C0178824
Disease	rheumatoid arthritis, smoking status measurement, ACPA-positive rheumatoid arthritis	HLA-DRB1 TAP2	1.41e-03	13	128	2	EFO_0000685, EFO_0006527, EFO_0009459
Disease	ventricular enlargement measurement	ABCC1 CATSPERB	1.41e-03	13	128	2	EFO_0010570
Disease	uveitis (is_implicated_in)	HLA-DRB1 IL1B	1.41e-03	13	128	2	DOID:13141 (is_implicated_in)
Disease	Leishmaniasis, Visceral	HLA-DRB1 IL1B	1.41e-03	13	128	2	C0023290
Disease	pleurisy (implicated_via_orthology)	BDKRB2 IL1B	1.41e-03	13	128	2	DOID:10247 (implicated_via_orthology)
Disease	Venous Engorgement	BDKRB2 IL1B	1.41e-03	13	128	2	C0042484
Disease	Paranoid Schizophrenia	HLA-DRB4 CCKAR	1.41e-03	13	128	2	C0036349
Disease	Active Hyperemia	BDKRB2 IL1B	1.41e-03	13	128	2	C0333233
Disease	Hyperemia	BDKRB2 IL1B	1.41e-03	13	128	2	C0020452
Disease	parental longevity	ERBB4 PDE3A HLA-DRB1 HECTD4 PSD3 TAP2 SMAD7 PSD4	1.45e-03	494	128	8	EFO_0007796
Disease	complement C4 measurement	HLA-DRB1 HLA-DRB5 TAP2	1.51e-03	52	128	3	EFO_0004984
Disease	C-C motif chemokine 19 measurement	HLA-DRB1 HLA-DRB5	1.64e-03	14	128	2	EFO_0008047
Disease	alcohol use disorder (implicated_via_orthology)	ERBB4 PSD PSD3 MAP4K1 PSD4	1.64e-03	195	128	5	DOID:1574 (implicated_via_orthology)
Disease	lymphocyte measurement	CBLN3 HLA-DRB1 HLA-DRB5 HOOK1	1.72e-03	117	128	4	EFO_0803546
Disease	Ischemic stroke, fibrinogen measurement	DIP2B HECTD4 LEPR	1.77e-03	55	128	3	EFO_0004623, HP_0002140
Disease	factor XI measurement, fibrinogen measurement, tissue plasminogen activator measurement, factor VII measurement	DIP2B HECTD4 LEPR	1.87e-03	56	128	3	EFO_0004619, EFO_0004623, EFO_0004694, EFO_0004791
Disease	pancreatic adenocarcinoma (is_implicated_in)	CDK4 SMAD7	1.89e-03	15	128	2	DOID:4074 (is_implicated_in)
Disease	lipid metabolism disorder (implicated_via_orthology)	LPIN1 LPIN2	1.89e-03	15	128	2	DOID:3146 (implicated_via_orthology)
Disease	retinal vasculature measurement	ERBB4 PDE3A HLA-DRB1 TTLL5 HLA-DRB5 PSD3 HOOK1 CPNE4	1.92e-03	517	128	8	EFO_0010554
Disease	response to vaccine	HLA-DRB1 HLA-DRB3 HLA-DRB5 TAP2	2.00e-03	122	128	4	EFO_0004645
Disease	rheumatoid arthritis (is_implicated_in)	HLA-DRB1 ADRB3 TAP2	2.07e-03	58	128	3	DOID:7148 (is_implicated_in)
Disease	fibrinogen measurement, factor VII measurement	DIP2B HECTD4 LEPR	2.07e-03	58	128	3	EFO_0004619, EFO_0004623
Disease	lung small cell carcinoma (is_marker_for)	ATRX ITGB1	2.15e-03	16	128	2	DOID:5409 (is_marker_for)
Disease	Urticaria	HLA-DRB1 IL1B	2.15e-03	16	128	2	C0042109
Disease	basophil measurement	ABCC1 GGCX THADA	2.28e-03	60	128	3	EFO_0803539
Disease	Inborn Errors of Metabolism	LEPR ABCD4	2.43e-03	17	128	2	C0025521
Disease	anti-anoctamin 2 antibody measurement	HLA-DRB1 HLA-DRB5	2.43e-03	17	128	2	EFO_0010150
Disease	Astrocytosis	ITGB1 LEPR	2.43e-03	17	128	2	C3887640
Disease	Lipidemias	LEPR ADRB3	2.43e-03	17	128	2	C1706412
Disease	response to interferon-beta, anti-drug antibody measurement	HLA-DRB1 HLA-DRB5	2.43e-03	17	128	2	EFO_0010559, GO_0035456
Disease	Gliosis	ITGB1 LEPR	2.43e-03	17	128	2	C0017639
Disease	Hyperlipidemia	LEPR ADRB3	2.43e-03	17	128	2	C0020473
Disease	systemic lupus erythematosus (is_implicated_in)	HLA-DRB1 IL1B TAP2	2.50e-03	62	128	3	DOID:9074 (is_implicated_in)
Disease	obesity (implicated_via_orthology)	LEPR CCKAR LPIN1 THADA LPIN2	2.51e-03	215	128	5	DOID:9970 (implicated_via_orthology)
Disease	mean reticulocyte volume	ABCC1 HLA-DRB1 THADA KANSL1 HOOK1 LPIN2 PUS1 LPGAT1 ENPP5 SLC35E3	2.58e-03	799	128	10	EFO_0010701
Disease	Alzheimer's disease (is_implicated_in)	HLA-DRB1 ADRB3 IL1B TAP2	2.66e-03	132	128	4	DOID:10652 (is_implicated_in)
Disease	late-onset myasthenia gravis	HLA-DRB1 HLA-DRB5	2.73e-03	18	128	2	EFO_1001490
Disease	rheumatoid arthritis, COVID-19	HLA-DRB1 FRYL TAP2	2.74e-03	64	128	3	EFO_0000685, MONDO_0100096
Disease	ankylosing spondylitis (is_implicated_in)	HLA-DRB1 TAP2	3.04e-03	19	128	2	DOID:7147 (is_implicated_in)
Disease	hepatitis B virus infection	HLA-DRB1 HLA-DRB3	3.04e-03	19	128	2	EFO_0004197
Disease	venous thromboembolism, fibrinogen measurement	DIP2B HECTD4 LEPR	3.12e-03	67	128	3	EFO_0004286, EFO_0004623
Disease	Cardiomyopathies, Primary	ITGB1 BDKRB2 IL1B	3.39e-03	69	128	3	C0033141
Disease	Myocardial Diseases, Secondary	ITGB1 BDKRB2 IL1B	3.39e-03	69	128	3	C0036529
Disease	Malignant Glioma	ATRX PSD3 ROS1	3.53e-03	70	128	3	C0555198
Disease	mixed gliomas	ATRX PSD3 ROS1	3.53e-03	70	128	3	C0259783
Disease	Henoch-Schoenlein purpura	HLA-DRB1 HLA-DRB5	4.07e-03	22	128	2	EFO_1000965
Disease	ubiquitin carboxyl-terminal hydrolase 25 measurement	HLA-DRB1 HLA-DRB5	4.07e-03	22	128	2	EFO_0021881

Protein segments in the cluster

Peptide	Gene	Start	Entry
FLNIQSWPPNMTDFS	ERBB4	401	Q15303
VMFISDNESFNPSLW	ERBIN	436	Q96RT1
PSLIWEVFTNMLLNV	BDKRB2	216	P30411
SFWECPNIVNIDLSM	ELFN1	151	P0C7U0
LFELLFNWSMSLPCN	BIRC6	3521	Q9NR09
KWFNNSAASLTMPTL	BPIFB1	261	Q8TDL5
SAPNNMTFLKSTWFL	CATSPERB	686	Q9H7T0
TIANFTFSAWVMPNA	ADGRV1	1351	Q8WXG9
PNDVMQQSWHTFLLL	CCKAR	201	P32238
QTWQCILSALMASLP	DNHD1	2151	Q96M86
LFPSWSSQNALMFLT	ABCD4	31	O14678
MTSATLNQPLWLNLN	C1orf94	451	Q6P1W5
AIAWTPRLQTMTNVF	ADRB3	61	P13945
LFFTQLQVGLIQQWM	DGAT1	286	O75907
NPMSDKLTFSVIWTL	DIS3L2	456	Q8IYB7
TNTICWNPMEAFIFT	DCAF13	241	Q9NV06
QRVEMNFISLFWPSL	MMP8	311	P22894
SPFDLEQQWQDLMSI	NFE2L1	306	Q14494
WSELFVLNAAQCSMP	NR2F1	256	P10589
MNLQPIFWIGLISSV	ITGB1	1	P05556
AWISSTVTPKMLNNF	OR5H15	71	A6NDH6
SPEWITASQMSLNSF	AOAH	271	P28039
LEPSSPQFVQMLSWT	FANCI	996	Q9NVI1
WYISTSQAENMPVFL	IL1B	236	P01584
FTTSCVPQMLVNLWG	OR2H2	71	O95918
QAVFLPMAAFLAWLS	PAQR7	171	Q86WK9
RSVPWLMTLNLSNNS	LRTM1	71	Q9HBL6
EMWQSYLILTAPLSQ	MDN1	5311	Q9NU22
MAPWLQLCSVFFTVN	IL17RD	1	Q8NFM7
EMTLSNLWIFLIQSF	LPGAT1	336	Q92604
LIQNGDWTFQTLVML	HLA-DRB5	176	Q30154
TLLMKQAWPQNSSSC	FAM168A	61	Q92567
PALNELLSVWNMGFS	MBTPS1	756	Q14703
FISLFNSVSQWVQLM	RASGRP2	196	Q7LDG7
QQPSEDWMILEFSQL	MGAT4B	286	Q9UQ53
SPIFTQFLDCIWQLM	MTMR8	396	Q96EF0
DHVVWSLFNTLFMNP	IFITM3	56	Q01628
LISWFAIHPVSMNNS	ASAH2	296	Q9NR71
LWPIMVSELIQTFTQ	DOP1B	2091	Q9Y3R5
LSPNFQITAMWSKDS	FCRL5	241	Q96RD9
ILLNSQMLDFSWPNR	GGT7	506	Q9UJ14
MVWENQTFNSIFILL	OR2M4	1	Q96R27
PKMLAIFWFNSTTIQ	OR51E1	81	Q8TCB6
TLTTLPTVMQLLWFN	OR51Q1	76	Q8NH59
MEQLNTWNFPIFDLV	PDE3A	686	Q14432
SFWNVQDLLNSAMPR	ENPP5	391	Q9UJA9
AFNTLQALMLDFPDW	FRYL	596	O94915
QSTTEPTNLMATIFW	FRYL	1991	O94915
PTNLMATIFWIAASL	FRYL	1996	O94915
WIQIMFLFQQSLFPE	VEPH1	616	Q14D04
FMLPWQFAQFVLLTQ	DPY19L1	251	Q2PZI1
PMELENNLFLWLSTV	DIP2B	1226	Q9P265
PTSLHFQSMLKSQWQ	KANSL1	676	Q7Z3B3
WTTAAPLLLAMQAFQ	LPIN1	516	Q14693
NFNLTFSWPMSKVNI	LEPR	726	P48357
FSWPMSKVNIVQSLS	LEPR	731	P48357
PASMLNWTTLQRLNA	GDPD5	296	Q8WTR4
SLLMAPESNAAQIWT	HECTD4	1671	Q9Y4D8
SEWISQMATLPQASN	HUWE1	1511	Q7Z6Z7
AWISSTVTPKMLNNF	OR5H1	71	A6NKK0
QLWASLTPASTQQEM	FAM171A2	171	A8MVW0
DLQWLVQPTLISSMA	FOSB	66	P53539
SVLSVTIFMFLQWPN	GPR149	81	Q86SP6
LMAASLYNNTVPELW	DNAH1	4061	Q9P2D7
LIQNGDWTFQTLVML	HLA-DRB3	176	P79483
TALVVCPLNTALNWM	ATRX	1621	P46100
LLQSTYATPVDMWSV	CDK4	186	P11802
FALWQMTAEDFQPLL	COL20A1	916	Q9P218
TEVVMNNLSPAWKSF	CPNE4	196	Q96A23
DPSVAQEMNTFISLW	DNAI7	106	Q6TDU7
TEACTENPNWALLMF	DNAI7	631	Q6TDU7
TMLWLALSSAAAAQP	DHRS12	261	A0PJE2
LIQNGDWTFQTLVML	HLA-DRB1	176	P01911
LIQNGDWTFQTLVML	HLA-DRB4	176	P13762
PSTNKTMLWNSFQIS	HAUS6	746	Q7Z4H7
VSLMLNTWPVISAFA	CBLN3	141	Q6UW01
DSLMIWLQTFNTASP	HOOK1	16	Q9UJC3
NFWNLPTTAQVMIEA	PSG11	26	Q9UQ72
QWFIVLAVLNSAMNP	S1PR3	281	Q99500
WTQFVNVTFQMEPTI	DSEL	661	Q8IZU8
PTMENQVQTLTSYLW	METTL17	81	Q9H7H0
DIWNSLSSVFTEMQP	MENT	321	Q9BUN1
FYSWLQQSTTTMLPL	PEX1	466	O43933
SQFLEWVNLEPQSMV	DRP2	576	Q13474
FIWFLIPIVNISQMS	OR11G2	191	Q8NGC1
MNPQTNATLAASAWL	OR2AT4	141	A6NND4
QNLFLSPWSISSTMA	SERPINB2	26	P05120
FTTSCVPQMLVNLWG	OR2H1	71	Q9GZK4
MLLSNSSWRLSQPSF	OR52L1	16	Q8NGH7
DLATYINMIWSAPLQ	ABCC1	436	P33527
MLFPSRTTWVYSINN	MAP4K1	536	Q92918
SQTLSPTWNQMLLFN	FER1L6	866	Q2WGJ9
NLFVTWQQRSTPATM	SZT2	2816	Q5T011
SPIWQNMCGLLSIFT	THADA	221	Q6YHU6
TWSMLQFPLDLAVQN	TMEM26	216	Q6ZUK4
AIQQMLFPNQEFSWL	SLC38A3	391	Q99624
VFLFQAPSLEQMQSW	PSD	846	A5PKW4
PDFNYILNMSLWSLT	TOP2B	1141	Q02880
WALDVLSPNLISTSM	RNASEH2A	91	O75792
SMTPFISALQSTDWL	SAMD8	96	Q96LT4
WSDTMNIFCPQDTII	SAMD7	421	Q7Z3H4
SMAQWLSTLPIHNFS	PUS1	386	Q9Y606
SIFPESLRWLMATQQ	SLC22A23	361	A1A5C7
LFMQSLWPQLTDGAT	HEPH	11	Q9BQS7
NFSVNMWNAITPLRT	PRDM7	431	Q9NQW5
LFQAPTAKEMSSWIA	PSD4	871	Q8NDX1
MTSWIVIFFLPVNSA	RXFP2	671	Q8WXD0
NVQRTPLMDNWYSLS	SLC5A8	506	Q8N695
DTTLMSNWLPLNANV	TAP2	256	Q03519
MNPENWTQVTSFVLL	OR6T1	1	Q8NGN1
INLMTADNLSICFWP	ARHGAP5	1401	Q13017
IFIWDLNNLNVPMTL	SEC31B	146	Q9NQW1
GSAAFITNSLMNPIW	SLC25A33	136	Q9BSK2
VSAPLQFMASALFIW	CLDND1	221	Q9NY35
MQQPWTGFTVQISFV	SMAD7	386	O15105
FQRTSWVQPLLMDLS	GGCX	496	P38435
AQSDNLTIWCMALSP	CD96	346	P40200
WINAFVMLTTQLLPS	TMEM39A	326	Q9NV64
SLWNISTVMAPNLFF	ARHGAP28	531	Q9P2N2
KNPVTIFSLATNEMW	SSBP1	51	Q04837
NISELSAMIPQFDWL	PHEX	301	P78562
WIAVNVTPSVMSFQL	ROS1	1101	P08922
FTSMPQLSEQWRQQL	UBQLNL	446	Q8IYU4
PLMNQIISWATLASS	PIGN	681	O95427
QTWFRFLHMLSNPVD	RALGAPB	281	Q86X10
QFPWLIMNEEQTALF	ZNF862	146	O60290
ETLISWLQAQMLNPQ	XPOT	81	O43592
TPNIWDLSMLFAFIS	VEZT	141	Q9HBM0
WVTAFLNHPQLSAMI	TSPY26P	196	Q9H489
LLFQTQSPEEMQGWI	PSD3	876	Q9NYI0
FPNMSLTLVHFVVTW	SLC35E3	41	Q7Z769
IFGSQTLPNSNLWTM	TTLL5	1176	Q6EMB2
QEPFLQWLMLLSNES	TPP1	301	O14773
GNLSFLNWLTMVPSL	LMF1	306	Q96S06
WALAAPMILSLQVFQ	LPIN2	521	Q92539
FQLPQWSISLNMTDE	MXRA5	311	Q9NR99
LDSFMQPFQSTLWLL	GRIN1	551	Q05586