Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sodium ion binding	SCN1A SCN2A SCN3A SCN8A	1.10e-08	14	38	4	GO:0031402
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN1A SCN2A SCN3A SCN8A	1.62e-07	26	38	4	GO:0005248
GeneOntologyMolecularFunction	alkali metal ion binding	SCN1A SCN2A SCN3A SCN8A	1.62e-07	26	38	4	GO:0031420
GeneOntologyMolecularFunction	sodium channel activity	SCN1A SCN2A SCN3A SCN8A	2.83e-06	52	38	4	GO:0005272
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SCN1A SCN2A SCN3A SCN8A	3.05e-04	171	38	4	GO:0015081
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	SCN1A SCN2A	4.71e-04	17	38	2	GO:0099508
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	KMT2B ASH1L	6.56e-04	20	38	2	GO:0042800
GeneOntologyMolecularFunction	protein domain specific binding	BLNK POU3F3 SP100 TACC1 PRKDC CARD8 SCN2A	1.16e-03	875	38	7	GO:0019904
GeneOntologyBiologicalProcess	membrane depolarization during action potential	SCN1A SCN2A SCN3A SCN8A	4.95e-07	36	37	4	GO:0086010
GeneOntologyBiologicalProcess	membrane depolarization	GCLC SCN1A SCN2A SCN3A SCN8A	2.40e-06	121	37	5	GO:0051899
GeneOntologyBiologicalProcess	cardiac muscle cell action potential involved in contraction	SCN1A SCN2A SCN3A SCN8A	4.54e-06	62	37	4	GO:0086002
GeneOntologyBiologicalProcess	neuronal action potential	SCN1A SCN2A SCN3A SCN8A	4.84e-06	63	37	4	GO:0019228
GeneOntologyBiologicalProcess	cardiac muscle cell action potential	SCN1A SCN2A SCN3A SCN8A	1.75e-05	87	37	4	GO:0086001
GeneOntologyBiologicalProcess	cardiac muscle cell contraction	SCN1A SCN2A SCN3A SCN8A	2.28e-05	93	37	4	GO:0086003
GeneOntologyBiologicalProcess	action potential	FOXP1 SCN1A SCN2A SCN3A SCN8A	2.83e-05	201	37	5	GO:0001508
GeneOntologyBiologicalProcess	nerve development	MNX1 SCN1A SCN2A SCN8A	4.26e-05	109	37	4	GO:0021675
GeneOntologyBiologicalProcess	transmission of nerve impulse	SCN1A SCN2A SCN3A SCN8A	4.74e-05	112	37	4	GO:0019226
GeneOntologyBiologicalProcess	actin-mediated cell contraction	SCN1A SCN2A SCN3A SCN8A	7.73e-05	127	37	4	GO:0070252
GeneOntologyBiologicalProcess	brain development	PITPNM1 FOXP1 POU3F3 DMXL2 TACC1 PRKDC PTF1A SCN2A	1.15e-04	859	37	8	GO:0007420
GeneOntologyBiologicalProcess	immunoglobulin V(D)J recombination	FOXP1 PRKDC	1.40e-04	10	37	2	GO:0033152
GeneOntologyBiologicalProcess	actin filament-based movement	SCN1A SCN2A SCN3A SCN8A	1.59e-04	153	37	4	GO:0030048
GeneOntologyBiologicalProcess	head development	PITPNM1 FOXP1 POU3F3 DMXL2 TACC1 PRKDC PTF1A SCN2A	1.84e-04	919	37	8	GO:0060322
GeneOntologyBiologicalProcess	central nervous system development	PITPNM1 FOXP1 POU3F3 DMXL2 TACC1 PRKDC MNX1 PTF1A SCN2A	2.06e-04	1197	37	9	GO:0007417
GeneOntologyBiologicalProcess	cardiac muscle contraction	SCN1A SCN2A SCN3A SCN8A	2.22e-04	167	37	4	GO:0060048
GeneOntologyBiologicalProcess	telencephalon development	FOXP1 POU3F3 DMXL2 TACC1 SCN2A	2.99e-04	332	37	5	GO:0021537
GeneOntologyBiologicalProcess	cellular response to antibiotic	PLA2G4A SCN3A	3.70e-04	16	37	2	GO:0071236
GeneOntologyBiologicalProcess	regulation of membrane potential	FOXP1 GCLC SCN1A SCN2A SCN3A SCN8A	4.39e-04	559	37	6	GO:0042391
GeneOntologyBiologicalProcess	sodium ion transmembrane transport	SCN1A SCN2A SCN3A SCN8A	5.11e-04	208	37	4	GO:0035725
GeneOntologyBiologicalProcess	striated muscle contraction	SCN1A SCN2A SCN3A SCN8A	5.99e-04	217	37	4	GO:0006941
GeneOntologyBiologicalProcess	positive regulation of immune response	BLNK PLA2G4A FOXP1 PRKDC GBP4 FCHO1 CARD8	6.63e-04	845	37	7	GO:0050778
GeneOntologyBiologicalProcess	V(D)J recombination	FOXP1 PRKDC	7.74e-04	23	37	2	GO:0033151
GeneOntologyBiologicalProcess	negative regulation of cilium assembly	KIF24 WDR44	7.74e-04	23	37	2	GO:1902018
GeneOntologyBiologicalProcess	activation of immune response	BLNK FOXP1 PRKDC GBP4 FCHO1 CARD8	7.76e-04	623	37	6	GO:0002253
GeneOntologyBiologicalProcess	ovulation	PLA2G4A KMT2B	8.43e-04	24	37	2	GO:0030728
GeneOntologyBiologicalProcess	immature B cell differentiation	FOXP1 PRKDC	9.15e-04	25	37	2	GO:0002327
GeneOntologyBiologicalProcess	blood circulation	ARHGEF12 GCLC SCN1A SCN2A SCN3A SCN8A	9.52e-04	648	37	6	GO:0008015
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN1A SCN2A SCN3A SCN8A	2.17e-08	17	38	4	GO:0001518
GeneOntologyCellularComponent	sodium channel complex	SCN1A SCN2A SCN3A SCN8A	2.13e-07	29	38	4	GO:0034706
GeneOntologyCellularComponent	node of Ranvier	SCN1A SCN2A SCN8A	6.18e-06	20	38	3	GO:0033268
GeneOntologyCellularComponent	axon initial segment	SCN1A SCN2A SCN8A	1.96e-05	29	38	3	GO:0043194
GeneOntologyCellularComponent	main axon	SCN1A SCN2A SCN8A	5.65e-04	89	38	3	GO:0044304
GeneOntologyCellularComponent	cation channel complex	SCN1A SCN2A SCN3A SCN8A	8.51e-04	235	38	4	GO:0034703
HumanPheno	Simple febrile seizure	SCN1A SCN2A SCN3A SCN8A	1.82e-06	27	18	4	HP:0011171
HumanPheno	Generalized clonic seizure	DMXL2 SCN1A SCN2A SCN8A	4.74e-06	34	18	4	HP:0011169
HumanPheno	Clonic seizure	DMXL2 SCN1A SCN2A SCN3A SCN8A	6.54e-06	81	18	5	HP:0020221
HumanPheno	Focal automatism seizure	SCN1A SCN2A SCN8A	7.99e-06	12	18	3	HP:0032898
HumanPheno	Focal clonic seizure	DMXL2 SCN1A SCN2A SCN8A	1.12e-05	42	18	4	HP:0002266
HumanPheno	Complex febrile seizure	SCN1A SCN2A SCN8A	2.02e-05	16	18	3	HP:0011172
HumanPheno	Choreoathetosis	POU3F3 DMXL2 SCN1A SCN2A SCN8A	5.04e-05	123	18	5	HP:0001266
HumanPheno	Generalized tonic seizure	DMXL2 SCN1A SCN2A SCN8A	6.08e-05	64	18	4	HP:0010818
HumanPheno	Multifocal epileptiform discharges	DMXL2 SCN1A SCN2A SCN8A	6.86e-05	66	18	4	HP:0010841
HumanPheno	Focal hemiclonic seizure	SCN1A SCN2A SCN8A	8.12e-05	25	18	3	HP:0006813
HumanPheno	Abnormal myelination	FOXP1 POU3F3 DMXL2 PRKDC SCN1A SCN2A SCN3A SCN8A ASH1L	9.96e-05	622	18	9	HP:0012447
HumanPheno	Infection-related seizure	DMXL2 SCN1A SCN2A SCN3A SCN8A	1.11e-04	145	18	5	HP:0032892
HumanPheno	Seizure precipitated by febrile infection	DMXL2 SCN1A SCN2A SCN3A SCN8A	1.11e-04	145	18	5	HP:0032894
HumanPheno	Febrile seizure (within the age range of 3 months to 6 years)	DMXL2 SCN1A SCN2A SCN3A SCN8A	1.11e-04	145	18	5	HP:0002373
HumanPheno	Focal head nodding automatism seizure	SCN2A SCN8A	1.17e-04	5	18	2	HP:0032906
HumanPheno	Neonatal electro-clinical non-motor seizure	SCN2A SCN8A	1.17e-04	5	18	2	HP:0032812
HumanPheno	Neonatal seizure with electrographic correlate	SCN2A SCN8A	1.17e-04	5	18	2	HP:0032808
HumanPheno	Neonatal electro-clinical seizure	SCN2A SCN8A	1.17e-04	5	18	2	HP:0032809
HumanPheno	Neonatal electro-clinical seizure with behavior arrest	SCN2A SCN8A	1.17e-04	5	18	2	HP:0032823
HumanPheno	Compulsive behaviors	FOXP1 SCN1A SCN2A SCN8A ASH1L	1.66e-04	158	18	5	HP:0000722
HumanPheno	Normal interictal EEG	SCN2A SCN8A	1.75e-04	6	18	2	HP:0002372
HumanPheno	Obsessive-compulsive trait	SCN1A SCN2A ASH1L	1.89e-04	33	18	3	HP:0008770
HumanPheno	Autistic behavior	FOXP1 POU3F3 DMXL2 KMT2B SCN1A SCN2A SCN3A SCN8A ASH1L	1.97e-04	678	18	9	HP:0000729
HumanPheno	Athetosis	POU3F3 DMXL2 SCN1A SCN2A SCN8A	2.10e-04	166	18	5	HP:0002305
HumanPheno	EEG with spike-wave complexes	DMXL2 SCN1A SCN2A SCN8A	2.12e-04	88	18	4	HP:0010850
HumanPheno	Eyelid myoclonia seizure	SCN2A SCN8A	2.45e-04	7	18	2	HP:0032678
HumanPheno	Delayed myelination	FOXP1 POU3F3 DMXL2 SCN1A SCN2A ASH1L	2.77e-04	280	18	6	HP:0012448
HumanPheno	Hyperactivity	FOXP1 DMXL2 KMT2B SCN1A SCN2A SCN3A SCN8A ASH1L	3.18e-04	558	18	8	HP:0000752
HumanPheno	Photosensitive myoclonic seizure	SCN1A SCN2A	3.26e-04	8	18	2	HP:0001327
HumanPheno	Cyanotic episode	SCN1A SCN2A	3.26e-04	8	18	2	HP:0200048
HumanPheno	Focal non-motor seizure	SCN1A SCN2A SCN8A	3.37e-04	40	18	3	HP:0032679
HumanPheno	Hypsarrhythmia	DMXL2 SCN1A SCN2A SCN3A SCN8A	3.49e-04	185	18	5	HP:0002521
HumanPheno	Diagnostic behavioral phenotype	FOXP1 POU3F3 DMXL2 KMT2B SCN1A SCN2A SCN3A SCN8A ASH1L	4.18e-04	747	18	9	HP:0025783
HumanPheno	Sudden unexpected death in epilepsy	SCN1A SCN8A	5.22e-04	10	18	2	HP:0033258
HumanPheno	Limited neck range of motion	SCN1A SCN2A	6.37e-04	11	18	2	HP:0000466
HumanPheno	Neonatal seizure	SCN2A SCN8A	6.37e-04	11	18	2	HP:0032807
HumanPheno	EEG with focal epileptiform discharges	DMXL2 SCN1A SCN2A SCN8A	6.51e-04	118	18	4	HP:0011185
HumanPheno	Epileptic encephalopathy	SCN1A SCN2A SCN3A SCN8A	6.72e-04	119	18	4	HP:0200134
HumanPheno	Bilateral tonic-clonic seizure with focal onset	SCN1A SCN2A SCN8A	7.35e-04	52	18	3	HP:0007334
HumanPheno	Epilepsia partialis continua	SCN1A SCN2A	7.62e-04	12	18	2	HP:0012847
HumanPheno	Focal impaired awareness seizure	SCN1A SCN2A SCN3A SCN8A	8.34e-04	126	18	4	HP:0002384
HumanPheno	Generalized cerebral atrophy/hypoplasia	SCN1A SCN2A	8.99e-04	13	18	2	HP:0007058
HumanPheno	Focal motor seizure	DMXL2 SCN1A SCN2A SCN8A	9.66e-04	131	18	4	HP:0011153
HumanPheno	Aortopulmonary collateral arteries	SCN1A SCN2A	1.21e-03	15	18	2	HP:0031834
HumanPheno	Photosensitive tonic-clonic seizure	SCN1A SCN2A	1.21e-03	15	18	2	HP:0007207
HumanPheno	Facial tics	SCN1A SCN2A	1.21e-03	15	18	2	HP:0011468
HumanPheno	Tonic seizure	DMXL2 SCN1A SCN2A SCN8A	1.24e-03	140	18	4	HP:0032792
HumanPheno	Myoclonus	DMXL2 KMT2B SCN1A SCN2A SCN3A SCN8A	1.25e-03	371	18	6	HP:0001336
HumanPheno	Chorea	POU3F3 DMXL2 SCN1A SCN2A SCN8A	1.33e-03	248	18	5	HP:0002072
HumanPheno	Dysgenesis of the hippocampus	SCN1A SCN2A	1.37e-03	16	18	2	HP:0025101
HumanPheno	Dialeptic seizure	DMXL2 SCN1A SCN2A SCN3A SCN8A	1.41e-03	251	18	5	HP:0011146
HumanPheno	Atypical absence status epilepticus	SCN1A SCN2A	1.55e-03	17	18	2	HP:0011151
HumanPheno	Focal motor status epilepticus	SCN1A SCN2A	1.55e-03	17	18	2	HP:0032663
HumanPheno	Focal emotional seizure with laughing	SCN1A SCN2A	1.55e-03	17	18	2	HP:0010821
HumanPheno	Impulsivity	SCN1A SCN2A SCN3A SCN8A	1.56e-03	149	18	4	HP:0100710
HumanPheno	Uni- and bilateral multifocal epileptiform discharges	DMXL2 SCN2A	1.75e-03	18	18	2	HP:0011190
HumanPheno	Visually-induced seizure	SCN1A SCN2A	1.75e-03	18	18	2	HP:0020216
HumanPheno	Generalized non-convulsive status epilepticus without coma	SCN1A SCN2A	1.75e-03	18	18	2	HP:0032860
HumanPheno	Focal emotional seizure	SCN1A SCN2A	1.75e-03	18	18	2	HP:0025613
HumanPheno	EEG with generalized epileptiform discharges	DMXL2 SCN1A SCN2A SCN3A SCN8A	1.95e-03	270	18	5	HP:0011198
HumanPheno	Drooling	FOXP1 POU3F3 SCN1A SCN2A	2.08e-03	161	18	4	HP:0002307
HumanPheno	Protein-losing enteropathy	BLNK CARD8	2.16e-03	20	18	2	HP:0002243
HumanPheno	Non-convulsive status epilepticus without coma	SCN1A SCN2A	2.16e-03	20	18	2	HP:0032671
HumanPheno	Psychomotor deterioration	SCN2A SCN8A	2.16e-03	20	18	2	HP:0002361
HumanPheno	Absent thumbnail	DMXL2 SCN2A	2.16e-03	20	18	2	HP:0012554
HumanPheno	Brain imaging abnormality	FOXP1 SCN1A SCN2A SCN8A	2.38e-03	167	18	4	HP:0410263
HumanPheno	Talipes valgus	SCN1A SCN2A	2.38e-03	21	18	2	HP:0004684
HumanPheno	Excessive salivation	FOXP1 POU3F3 SCN1A SCN2A	2.54e-03	170	18	4	HP:0003781
HumanPheno	Focal sensory seizure	SCN1A SCN8A	2.61e-03	22	18	2	HP:0011157
HumanPheno	Reflex seizure	SCN1A SCN2A	2.61e-03	22	18	2	HP:0020207
HumanPheno	B-cell lymphoma	FOXP1 FCHO1	2.61e-03	22	18	2	HP:0012191
HumanPheno	Abnormal small intestine morphology	BLNK PLA2G4A GCLC PTF1A CARD8	2.64e-03	289	18	5	HP:0002244
Domain	Na_trans_cytopl	SCN1A SCN2A SCN3A SCN8A	1.95e-10	6	37	4	PF11933
Domain	Na_trans_cytopl	SCN1A SCN2A SCN3A SCN8A	1.95e-10	6	37	4	IPR024583
Domain	Na_channel_asu	SCN1A SCN2A SCN3A SCN8A	2.71e-09	10	37	4	IPR001696
Domain	Na_trans_assoc	SCN1A SCN2A SCN3A SCN8A	2.71e-09	10	37	4	IPR010526
Domain	Na_trans_assoc	SCN1A SCN2A SCN3A SCN8A	2.71e-09	10	37	4	PF06512
Domain	Channel_four-helix_dom	SCN1A SCN2A SCN3A SCN8A	4.78e-06	57	37	4	IPR027359
Domain	-	SCN1A SCN2A SCN3A SCN8A	4.78e-06	57	37	4	1.20.120.350
Domain	IQ	SCN1A SCN2A SCN3A SCN8A	1.94e-05	81	37	4	SM00015
Domain	IQ_motif_EF-hand-BS	SCN1A SCN2A SCN3A SCN8A	2.95e-05	90	37	4	IPR000048
Domain	IQ	SCN1A SCN2A SCN3A SCN8A	3.35e-05	93	37	4	PS50096
Domain	Ion_trans_dom	SCN1A SCN2A SCN3A SCN8A	7.44e-05	114	37	4	IPR005821
Domain	Ion_trans	SCN1A SCN2A SCN3A SCN8A	7.44e-05	114	37	4	PF00520
Domain	BAH	TNRC18 ASH1L	2.08e-04	11	37	2	SM00439
Domain	BAH	TNRC18 ASH1L	2.08e-04	11	37	2	PF01426
Domain	BAH_dom	TNRC18 ASH1L	2.08e-04	11	37	2	IPR001025
Domain	BAH	TNRC18 ASH1L	2.08e-04	11	37	2	PS51038
Domain	IQ	SCN1A SCN3A SCN8A	3.73e-04	71	37	3	PF00612
Domain	Post-SET_dom	KMT2B ASH1L	4.50e-04	16	37	2	IPR003616
Domain	PostSET	KMT2B ASH1L	4.50e-04	16	37	2	SM00508
Domain	POST_SET	KMT2B ASH1L	4.50e-04	16	37	2	PS50868
Domain	AT_hook	KMT2B ASH1L	1.30e-03	27	37	2	SM00384
Domain	AT_hook_DNA-bd_motif	KMT2B ASH1L	1.30e-03	27	37	2	IPR017956
Domain	RGS	ARHGEF12 SNX25	2.70e-03	39	37	2	IPR016137
Domain	SET	KMT2B ASH1L	2.98e-03	41	37	2	PF00856
Domain	UBA	UBL7 SIK2	3.43e-03	44	37	2	IPR015940
Domain	SET	KMT2B ASH1L	3.74e-03	46	37	2	SM00317
Domain	UBA	UBL7 SIK2	3.90e-03	47	37	2	PS50030
Domain	SET_dom	KMT2B ASH1L	4.41e-03	50	37	2	IPR001214
Domain	SET	KMT2B ASH1L	4.41e-03	50	37	2	PS50280
Domain	PHD	KMT2B ASH1L	9.68e-03	75	37	2	PF00628
Domain	Znf_PHD-finger	KMT2B ASH1L	1.07e-02	79	37	2	IPR019787
Pathway	WP_DRAVET_SYNDROME	SCN1A SCN2A SCN3A SCN8A	3.78e-07	28	31	4	M45519
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SCN1A SCN2A SCN3A SCN8A	5.78e-07	31	31	4	M877
Pathway	REACTOME_PHASE_0_RAPID_DEPOLARISATION	SCN1A SCN2A SCN3A SCN8A	6.59e-07	32	31	4	M27455
Pathway	REACTOME_L1CAM_INTERACTIONS	SCN1A SCN2A SCN3A SCN8A	1.36e-04	121	31	4	M872
Pathway	WP_RETT_SYNDROME	SCN1A SCN2A SCN8A	1.56e-04	48	31	3	M39759
Pathway	REACTOME_CARDIAC_CONDUCTION	SCN1A SCN2A SCN3A SCN8A	1.79e-04	130	31	4	M27454
Pathway	WP_OMEGA3_OMEGA6_FATTY_ACID_SYNTHESIS	FADS2 PLA2G4A	4.83e-04	15	31	2	M39789
Pathway	WP_OMEGA3_OMEGA6_FATTY_ACID_SYNTHESIS	FADS2 PLA2G4A	5.51e-04	16	31	2	MM15813
Pathway	KEGG_ALPHA_LINOLENIC_ACID_METABOLISM	FADS2 PLA2G4A	7.82e-04	19	31	2	M311
Pathway	REACTOME_MUSCLE_CONTRACTION	SCN1A SCN2A SCN3A SCN8A	9.69e-04	203	31	4	M5485
Pathway	WP_ADHD_AND_AUTISM_ASD_PATHWAYS	ATG2A SCN1A SCN2A SCN3A SCN8A	1.13e-03	367	31	5	M48346
Pubmed	Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.	SCN1A SCN2A SCN3A SCN8A	1.21e-12	4	38	4	17537961
Pubmed	Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.	SCN1A SCN2A SCN3A SCN8A	1.21e-12	4	38	4	35031483
Pubmed	Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.	SCN1A SCN2A SCN3A SCN8A	1.21e-12	4	38	4	29578003
Pubmed	A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.	SCN1A SCN2A SCN3A SCN8A	1.81e-11	6	38	4	23652591
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN1A SCN2A SCN3A SCN8A	1.52e-10	9	38	4	16382098
Pubmed	Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.	SCN1A SCN2A SCN3A SCN8A	1.52e-10	9	38	4	15746173
Pubmed	Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.	SCN1A SCN2A SCN3A SCN8A	5.96e-10	12	38	4	30175250
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	SCN1A SCN2A SCN3A SCN8A	8.60e-10	13	38	4	15123669
Pubmed	Sodium channels SCN1A, SCN2A and SCN3A in familial autism.	SCN1A SCN2A SCN3A	1.20e-09	3	38	3	12610651
Pubmed	SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.	SCN1A SCN2A SCN3A	1.20e-09	3	38	3	23859570
Pubmed	Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.	SCN1A SCN2A SCN3A	1.20e-09	3	38	3	18784617
Pubmed	Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.	SCN1A SCN2A SCN3A	1.20e-09	3	38	3	17544618
Pubmed	Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.	SCN1A SCN2A SCN8A	1.20e-09	3	38	3	32845893
Pubmed	Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.	SCN1A SCN2A SCN8A	1.20e-09	3	38	3	28518218
Pubmed	Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.	SCN1A SCN2A SCN8A	1.20e-09	3	38	3	17928448
Pubmed	Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.	SCN1A SCN2A SCN3A	1.20e-09	3	38	3	14973256
Pubmed	Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.	SCN1A SCN2A SCN8A	4.81e-09	4	38	3	21156207
Pubmed	Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.	SCN1A SCN2A SCN3A	4.81e-09	4	38	3	35801810
Pubmed	Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.	SCN1A SCN2A SCN3A	4.81e-09	4	38	3	8974318
Pubmed	Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.	SCN1A SCN2A SCN3A	1.20e-08	5	38	3	1679748
Pubmed	A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.	SCN1A SCN2A SCN3A	1.20e-08	5	38	3	8812438
Pubmed	Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.	SCN2A SCN3A SCN8A	1.20e-08	5	38	3	17724025
Pubmed	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.	SCN1A SCN2A SCN3A	1.20e-08	5	38	3	24337656
Pubmed	Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.	SCN1A SCN2A SCN8A	4.20e-08	7	38	3	25818041
Pubmed	Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.	SCN1A SCN2A SCN3A	2.63e-07	12	38	3	8169823
Pubmed	Confirmation of quantitative trait loci for alcohol preference in mice.	SCN1A SCN2A SCN3A	5.43e-07	15	38	3	9726281
Pubmed	Association between SCN1A and SCN2A mutations and clinical/EEG features in Chinese patients from epilepsy or severe seizures.	SCN1A SCN2A	1.16e-06	2	38	2	29649454
Pubmed	Array-CGH detection of a de novo 2.8 Mb deletion in 2q24.2-->q24.3 in a girl with autistic features and developmental delay.	SCN2A SCN3A	1.16e-06	2	38	2	20346423
Pubmed	Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy.	SCN1A SCN8A	1.16e-06	2	38	2	37901435
Pubmed	An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior.	SCN1A SCN8A	1.16e-06	2	38	2	26410685
Pubmed	Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.	SCN1A SCN2A	1.16e-06	2	38	2	10827969
Pubmed	Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population.	SCN1A SCN2A	1.16e-06	2	38	2	19694741
Pubmed	Commonalities and distinctions between two neurodevelopmental disorder subtypes associated with SCN2A and SCN8A variants and literature review.	SCN2A SCN8A	1.16e-06	2	38	2	35348308
Pubmed	Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus.	SCN2A SCN3A	1.16e-06	2	38	2	11245985
Pubmed	Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones.	SCN2A SCN8A	1.16e-06	2	38	2	15760941
Pubmed	Differential expression of two sodium channel subtypes in human brain.	SCN1A SCN2A	1.16e-06	2	38	2	1317301
Pubmed	Duplication of the sodium channel gene cluster on 2q24 in children with early onset epilepsy.	SCN2A SCN3A	1.16e-06	2	38	2	23016767
Pubmed	Whole gene duplication of SCN2A and SCN3A is associated with neonatal seizures and a normal intellectual development.	SCN2A SCN3A	1.16e-06	2	38	2	27153334
Pubmed	Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children.	SCN1A SCN2A	1.16e-06	2	38	2	33096315
Pubmed	Electrophysiological Differences between the Same Pore Region Mutation in SCN1A and SCN3A.	SCN1A SCN3A	1.16e-06	2	38	2	24990319
Pubmed	Clinical exome sequencing identifies two novel mutations of the SCN1A and SCN2A genes in Moroccan patients with epilepsy: a case series.	SCN1A SCN2A	1.16e-06	2	38	2	31439038
Pubmed	Sodium channel expression within chronic multiple sclerosis plaques.	SCN2A SCN8A	1.16e-06	2	38	2	17805013
Pubmed	Missense mutations in sodium channel SCN1A and SCN2A predispose children to encephalopathy with severe febrile seizures.	SCN1A SCN2A	1.16e-06	2	38	2	26311622
Pubmed	Aberrant regulation of a poison exon caused by a non-coding variant in a mouse model of Scn1a-associated epileptic encephalopathy.	SCN1A SCN8A	1.16e-06	2	38	2	33411788
Pubmed	Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome.	SCN1A SCN8A	1.16e-06	2	38	2	31943325
Pubmed	Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A.	SCN1A SCN2A	1.16e-06	2	38	2	15249644
Pubmed	Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a.	SCN1A SCN3A	1.16e-06	2	38	2	27690330
Pubmed	The developmental changes of Na(v)1.1 and Na(v)1.2 expression in the human hippocampus and temporal lobe.	SCN1A SCN2A	1.16e-06	2	38	2	21377452
Pubmed	Reduced expression of Na(v)1.6 sodium channels and compensation by Na(v)1.2 channels in mice heterozygous for a null mutation in Scn8a.	SCN2A SCN8A	1.16e-06	2	38	2	18601978
Pubmed	Correlations in timing of sodium channel expression, epilepsy, and sudden death in Dravet syndrome.	SCN1A SCN3A	1.16e-06	2	38	2	23965409
Pubmed	FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels.	SCN2A SCN8A	1.16e-06	2	38	2	19465131
Pubmed	Persistent Nav1.1 and Nav1.6 currents drive spinal locomotor functions through nonlinear dynamics.	SCN1A SCN8A	1.16e-06	2	38	2	37665666
Pubmed	The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy.	SCN1A SCN8A	1.16e-06	2	38	2	17881658
Pubmed	SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients.	SCN1A SCN2A	1.16e-06	2	38	2	30693367
Pubmed	Block of a subset of sodium channels exacerbates experimental autoimmune encephalomyelitis.	SCN2A SCN8A	1.16e-06	2	38	2	23735284
Pubmed	VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase.	PITPNM1 OSBPL9 WDR44	2.72e-06	25	38	3	24885147
Pubmed	Voltage-gated sodium channels in taste bud cells.	SCN2A SCN3A	3.48e-06	3	38	2	19284629
Pubmed	Nav1.2 is expressed in caudal ganglionic eminence-derived disinhibitory interneurons: Mutually exclusive distributions of Nav1.1 and Nav1.2.	SCN1A SCN2A	3.48e-06	3	38	2	28784306
Pubmed	Association of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy.	SCN1A SCN2A	3.48e-06	3	38	2	32185219
Pubmed	Clinical exome sequencing as the first-tier test for diagnosing developmental disorders covering both CNV and SNV: a Chinese cohort.	SCN1A SCN2A	3.48e-06	3	38	2	32005694
Pubmed	Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).	SCN1A SCN3A	3.48e-06	3	38	2	33895391
Pubmed	Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea.	SCN2A SCN8A	3.48e-06	3	38	2	16033895
Pubmed	Role of sodium channel subtype in action potential generation by neocortical pyramidal neurons.	SCN2A SCN8A	3.48e-06	3	38	2	29991598
Pubmed	GAPDH-mediated posttranscriptional regulations of sodium channel Scn1a and Scn3a genes under seizure and ketogenic diet conditions.	SCN1A SCN3A	3.48e-06	3	38	2	27816501
Pubmed	Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance.	SCN1A SCN8A	3.48e-06	3	38	2	24704313
Pubmed	Gene-to-gene interaction between sodium channel-related genes in determining the risk of antiepileptic drug resistance.	SCN1A SCN2A	3.48e-06	3	38	2	19270815
Pubmed	Identification of functional voltage-gated Na(+) channels in cultured human pulmonary artery smooth muscle cells.	SCN2A SCN3A	3.48e-06	3	38	2	16052353
Pubmed	Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy.	SCN1A SCN2A	3.48e-06	3	38	2	25155934
Pubmed	The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels.	SCN1A SCN8A	3.48e-06	3	38	2	28117367
Pubmed	Experimental and computational evidence that Calpain-10 binds to the carboxy terminus of NaV1.2 and NaV1.6.	SCN2A SCN8A	3.48e-06	3	38	2	38514708
Pubmed	Human Nav1.6 Channels Generate Larger Resurgent Currents than Human Nav1.1 Channels, but the Navβ4 Peptide Does Not Protect Either Isoform from Use-Dependent Reduction.	SCN1A SCN8A	3.48e-06	3	38	2	26182346
Pubmed	De novo SCN1A, SCN8A, and CLCN2 mutations in childhood absence epilepsy.	SCN1A SCN8A	3.48e-06	3	38	2	31054517
Pubmed	Pre-B-cell leukemias in Btk/Slp65-deficient mice arise independently of ongoing V(D)J recombination activity.	BLNK PRKDC	6.96e-06	4	38	2	21030983
Pubmed	Targeted DNA Sequencing from Autism Spectrum Disorder Brains Implicates Multiple Genetic Mechanisms.	SCN1A SCN2A	6.96e-06	4	38	2	26637798
Pubmed	Models for discovery of targeted therapy in genetic epileptic encephalopathies.	SCN1A SCN8A	6.96e-06	4	38	2	28742937
Pubmed	Interaction between the transcriptional corepressor Sin3B and voltage-gated sodium channels modulates functional channel expression.	SCN2A SCN8A	1.16e-05	5	38	2	24077057
Pubmed	TDP-43 is essential for Eph receptor-class-specific spinal motor axon trajectory into the limb.	FOXP1 MNX1	1.16e-05	5	38	2	34687812
Pubmed	Early development of electrical excitability in the mouse enteric nervous system.	SCN3A SCN8A	1.16e-05	5	38	2	22875929
Pubmed	Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone?	SCN2A SCN8A	1.74e-05	6	38	2	17513486
Pubmed	AGR2-Dependent Nuclear Import of RNA Polymerase II Constitutes a Specific Target of Pancreatic Ductal Adenocarcinoma in the Context of Wild-Type p53.	PRKDC PTF1A	1.74e-05	6	38	2	34303658
Pubmed	An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways.	SCN3A SCN8A	1.74e-05	6	38	2	23711479
Pubmed	Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation.	FOXP1 PRKDC	1.74e-05	6	38	2	28591638
Pubmed	PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance.	PRKDC PTF1A	2.43e-05	7	38	2	28087712
Pubmed	Analysis of transcription factors key for mouse pancreatic development establishes NKX2-2 and MNX1 mutations as causes of neonatal diabetes in man.	MNX1 PTF1A	2.43e-05	7	38	2	24411943
Pubmed	Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes.	SCN1A SCN8A	2.43e-05	7	38	2	15272007
Pubmed	Glucocorticoid signalling affects pancreatic development through both direct and indirect effects.	PRKDC PTF1A	3.24e-05	8	38	2	17001468
Pubmed	Spinal Locomotor Circuits Develop Using Hierarchical Rules Based on Motorneuron Position and Identity.	FOXP1 MNX1	3.24e-05	8	38	2	26335645
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	KMT2B ASH1L	3.24e-05	8	38	2	23130995
Pubmed	A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells.	MNX1 PTF1A	4.16e-05	9	38	2	26440894
Pubmed	Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals.	SCN1A SCN8A	4.16e-05	9	38	2	17884088
Pubmed	Foxp1-mediated programming of limb-innervating motor neurons from mouse and human embryonic stem cells.	FOXP1 MNX1	4.16e-05	9	38	2	25868900
Pubmed	A census of human transcription factors: function, expression and evolution.	NPAS3 FOXP1 POU3F3 SP100 MNX1 PTF1A ASH1L	5.03e-05	908	38	7	19274049
Pubmed	Common variants associated with general and MMR vaccine-related febrile seizures.	SCN1A SCN2A	5.20e-05	10	38	2	25344690
Pubmed	Cux-2 controls the proliferation of neuronal intermediate precursors of the cortical subventricular zone.	FOXP1 POU3F3	5.20e-05	10	38	2	18033766
Pubmed	A retrotransposon insertion in the 5' regulatory domain of Ptf1a results in ectopic gene expression and multiple congenital defects in Danforth's short tail mouse.	MNX1 PTF1A	5.20e-05	10	38	2	23437001
Pubmed	Genetic profile of patients with epilepsy on first-line antiepileptic drugs and potential directions for personalized treatment.	SCN1A SCN2A	5.20e-05	10	38	2	20602612
Pubmed	Vsx1 and Chx10 paralogs sequentially secure V2 interneuron identity during spinal cord development.	FOXP1 MNX1	6.35e-05	11	38	2	31822965
Pubmed	SorCS2 binds progranulin to regulate motor neuron development.	FOXP1 MNX1	6.35e-05	11	38	2	37897724
Pubmed	Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice.	MNX1 PTF1A	6.35e-05	11	38	2	16026781
Pubmed	Chx10 Consolidates V2a Interneuron Identity through Two Distinct Gene Repression Modes.	FOXP1 MNX1	6.35e-05	11	38	2	27477290
Interaction	SCN4B interactions	SCN1A SCN2A SCN8A	3.44e-07	8	38	3	int:SCN4B
Cytoband	2q24.3	SCN1A SCN2A	7.95e-05	16	38	2	2q24.3
Cytoband	Ensembl 112 genes in cytogenetic band chr2q24	SCN1A SCN2A SCN3A	1.62e-04	127	38	3	chr2q24
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN1A SCN2A SCN3A SCN8A	6.69e-10	9	29	4	1203
GeneFamily	PHD finger proteins	SP100 KMT2B ASH1L	3.97e-04	90	29	3	88
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2B ASH1L	1.35e-03	34	29	2	487
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_k-means-cluster#1_top-relative-expression-ranked_1000	RAD9B DMXL2 PRKDC SNX25	1.59e-05	85	38	4	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_k1_1000
CoexpressionAtlas	B cells, B1a.Sp, IgD+ IgM+ CD45R+ CD24+ CD19+ AA4.1- CD23- CD21/35-, Spleen, avg-3	BLNK ARHGEF12 FOXP1 DMXL2 GBP4 SNX25	2.94e-05	341	38	6	GSM538225_500
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_k-means-cluster#3_top-relative-expression-ranked_500	RAD9B DMXL2 PRKDC	4.27e-05	38	38	3	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_k3_500
ToppCell	PND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NPAS3 FRMPD3 SCN1A SCN3A STAB1	2.84e-07	165	38	5	347b59aa625a8a960828b8620824d8ac48990e07
ToppCell	PND03-Endothelial-Endothelial_lymphatic\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NPAS3 FRMPD3 SCN1A SCN3A STAB1	2.84e-07	165	38	5	1890f9c33b0c5b381d57f97042da2610a093a6de
ToppCell	PND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NPAS3 FRMPD3 SCN1A SCN3A STAB1	2.84e-07	165	38	5	507c89ece0a336b8e9c65b79889a714e17ddca27
ToppCell	PND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NPAS3 FRMPD3 SCN1A SCN3A STAB1	2.84e-07	165	38	5	39a25be081a5d59c7cf107a997d352793d5025fb
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-B_lymphocytic-naive_B_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	BLNK FOXP1 SP100 SCN2A SCN3A	5.71e-07	190	38	5	a7498fe55b7810c482291db782dc5282675d246a
ToppCell	PND01-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BLNK SP100 GBP4 FCHO1	1.17e-05	165	38	4	66f0364098d82629aa2ec1dfe0c5ad23de7c2c12
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Alveolar_fibro\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	RAD9B SNX25 WDR44 SCN8A	1.20e-05	166	38	4	65dafed953b01a9830b54309af75c7a561e88336
ToppCell	facs\|World / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FADS2 SP100 TACC1 KMT2B	1.38e-05	172	38	4	a2d0a64ebf09d219a07d6bbad1056bad6d46b9be
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RAD9B ARMCX4 SCN2A SCN8A	1.54e-05	177	38	4	8abdf1d970b2f15e17e185f3e612dd5065c88757
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BLNK POU3F3 SCN2A SCN3A	1.54e-05	177	38	4	dc846d0feb94d4c289553cc3ac9dac81d10409cb
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_7\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FADS2 KMT2B KIF24 STAB1	1.61e-05	179	38	4	42f3c040f504a91cc69292d39d22b5715c12526f
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_7\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FADS2 KMT2B KIF24 STAB1	1.61e-05	179	38	4	063c05753ef1b4a18bc1ebbcae62c8cd25d11070
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BLNK NPAS3 SCN2A SCN3A	1.61e-05	179	38	4	d3438fed0d85d5ed5afa8ff820c45143d77b6c0d
ToppCell	PCW_10-12-Immune_Lymphocytic-Immune_Lymphocytic_B-im_B_cell_(15)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	BLNK GBP4 FCHO1 SCN3A	1.68e-05	181	38	4	51e4d6bfdbf414d8e30aee2e6f7492f4f7f54373
ToppCell	Epithelial-lung_neuroendocrine_cell_(PNEC)\|World / Lineage, Cell type, age group and donor	NPAS3 SCN2A SCN3A SCN8A	1.72e-05	182	38	4	57bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BLNK FOXP1 SP100 GBP4	1.79e-05	184	38	4	b12fb85a064f715a4f0ada1df8e422c359b573cf
ToppCell	facs-Large_Intestine-Proximal-24m-Epithelial-enteroendocrine_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARMCX4 GBP4 SCN3A SCN8A	1.83e-05	185	38	4	2a8104f610fa5ce618f8105521616722462a0d42
ToppCell	facs-Marrow-T-cells-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BLNK FOXP1 SP100 GBP4	1.83e-05	185	38	4	e1fd0a807def8c2127194108b1a30c6de7024292
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NPAS3 SCN2A SCN3A SCN8A	1.87e-05	186	38	4	b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCell	Smart-seq2-blood_(Smart-seq2)-lymphocytic-B_lymphocytic-naive_B_cell\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	BLNK FOXP1 SP100 SCN3A	1.91e-05	187	38	4	160e5f338537d90d50f863a1be801b1071ac7da7
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BLNK TACC1 SCN2A SCN3A	1.95e-05	188	38	4	eec3d353e51358db4c7621265ee0fdd4298e5b0e
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NPAS3 SCN2A SCN3A SCN8A	1.95e-05	188	38	4	c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BLNK TACC1 SCN2A SCN3A	1.95e-05	188	38	4	bc089cd73d283ed7d2ecbb3936673b4edc89f666
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRMPD3 SCN1A SCN2A SCN8A	1.99e-05	189	38	4	f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-B_lymphocytic-naive_B_cell\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	BLNK SP100 SCN2A SCN3A	1.99e-05	189	38	4	e2bb5900d210386b7b74938e7a3636d0c7ba1bcf
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-B_lymphocytic-naive_B_cell\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	BLNK FOXP1 SP100 SCN3A	2.08e-05	191	38	4	b374676ac90572d65895052d46469906e2b6fd93
ToppCell	Fetal_29-31_weeks-Immune-B_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	BLNK SP100 FCHO1 SCN3A	2.08e-05	191	38	4	84452125d1b5b76974e3f9126f611eff16d45c25
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BLNK FOXP1 KIAA0930 SNX25	2.12e-05	192	38	4	2de242d81dc085ae734eb7d1f091af9a542e0866
ToppCell	COVID-19-kidney-CNT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	BLNK POU3F3 SCN2A SCN3A	2.12e-05	192	38	4	760c6b9628de9693034b00c5025c5c4df94bb2e8
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BLNK FOXP1 KIAA0930 SNX25	2.12e-05	192	38	4	ba2a683472a8b785dbf666dc6e94356d879486c3
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRMPD3 SCN1A SCN2A SCN8A	2.16e-05	193	38	4	5fb7808dd971c1cc64c2bd4f8f1de646fb2d77f4
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ARHGEF12 FOXP1 ARMCX4 GBP4	2.21e-05	194	38	4	44c7d4b75f3b7c9301eba20610e548a01a84ae40
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ARHGEF12 FOXP1 ARMCX4 GBP4	2.21e-05	194	38	4	7f24023df47935286f185dd428d48797daf26f49
ToppCell	Smart-seq2-bone_marrow_(Smart-seq2)-myeloid\|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DMXL2 KIAA0930 TNRC18 STAB1	2.25e-05	195	38	4	b0dbaae86f5703ab62f925e0f36500274044884a
ToppCell	COVID-19-kidney-VWF+PLVAP+VCAM1+EC\|kidney / Disease (COVID-19 only), tissue and cell type	TACC1 GBP4 CARD8 STAB1	2.30e-05	196	38	4	ac2c4a325efa8497a755cd31fb6a9d94d8e3bf42
ToppCell	control-B_naive\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	BLNK FOXP1 SP100 SCN3A	2.39e-05	198	38	4	c012b8fbfa8bbc5014217f47acf9177470d8a65a
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SCN1A SCN2A SCN3A SCN8A	2.39e-05	198	38	4	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NPAS3 SCN2A SCN3A SCN8A	2.39e-05	198	38	4	8f25e8dff42bad8e779ca618bdb1cb1610667962
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NPAS3 SCN2A SCN3A SCN8A	2.39e-05	198	38	4	e3e0aa3ef20b2370f5b133048510677aaa562dfa
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SCN1A SCN2A SCN3A SCN8A	2.39e-05	198	38	4	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SCN1A SCN2A SCN3A SCN8A	2.39e-05	198	38	4	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	control-Neutrophil\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DMXL2 KIAA0930 TNRC18 STAB1	2.48e-05	200	38	4	251ca08fab5cc2a4e280db6a6286a9ebaef3e61a
ToppCell	control-Neutrophil\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DMXL2 KIAA0930 TNRC18 STAB1	2.48e-05	200	38	4	b5d197472799cc61d7497faed91ac2564ae4930a
ToppCell	mild-B_naive\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	BLNK FOXP1 SP100 SCN3A	2.48e-05	200	38	4	222789b897e2a683bbfd1d00b6fd8705015d90df
ToppCell	control-HLA-DR-_S100A+_Monocyte\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DMXL2 KIAA0930 TNRC18 STAB1	2.48e-05	200	38	4	9e3e13a68bc1110fa000ec2d80f4c654ddbce17e
ToppCell	BAL-Control-cDC_7\|Control / Compartment, Disease Groups and Clusters	FADS2 KMT2B KIF24	1.49e-04	121	38	3	b49b044a687a31883dfccecf10a183b5ba567f7a
ToppCell	E16.5-samps-Myeloid-Fetal_macrophage-macrophage_-_intermediate_-_unactivated\|E16.5-samps / Age Group, Lineage, Cell class and subclass	BLNK SP100 STAB1	2.81e-04	150	38	3	60fdd266aaca1b589b9a77465a4a7fad4921339a
ToppCell	PND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BLNK SP100 FCHO1	2.81e-04	150	38	3	cc8361bdcaa16ab6a0d6a3684690d709bc42ff3b
ToppCell	PND01-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BLNK SP100 FCHO1	2.87e-04	151	38	3	ee56b88c56c3b6a5ec9644c43cae521ea0e05920
ToppCell	PND01-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BLNK SP100 FCHO1	2.87e-04	151	38	3	2c239b09970acbaa90c5ebe1097f453c516f868e
ToppCell	Smart-seq2-bone_marrow_(Smart-seq2)-lymphocytic-B_lymphocytic-naive_B_cell\|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	BLNK SP100 SCN3A	2.87e-04	151	38	3	0f8f07e44c6edaf09574930b416fdce14d67095a
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GCLC SCN1A SCN2A	2.87e-04	151	38	3	f41c6558a5874b6464c157027fdf202257c60e5b
ToppCell	normal_Lymph_Node-Myeloid_cells-mo-Mac\|Myeloid_cells / Location, Cell class and cell subclass	DMXL2 SNX25 STAB1	2.98e-04	153	38	3	5424494ea1f09542799045a875cc3eac13de5079
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NPAS3 FRMPD3 SNX25	3.10e-04	155	38	3	e7f49e2fdaf184fa6b4e685518004e7deff1316d
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SCN1A SCN2A SCN3A	3.10e-04	155	38	3	77fdae85d36efb776db977eb424b32487ef222e4
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NPAS3 FRMPD3 SNX25	3.10e-04	155	38	3	5a872ca70ae8c30b57f45a6772d7bf565e0c2663
ToppCell	PND07-Endothelial-Endothelial_lymphatic\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN1A SCN3A STAB1	3.46e-04	161	38	3	133b4fadb499e842c19f573f9cf09ce08c1d4813
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN1A SCN3A STAB1	3.46e-04	161	38	3	cb177ca10d848d0e25399ab5ebfcde1071fb94c2
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN1A SCN3A STAB1	3.46e-04	161	38	3	9466b8658244116f8d21f2f88fb8c2d184b1bdf2
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BLNK SCN2A SCN3A	3.52e-04	162	38	3	285e6d553f485fd9f1075c4e1b940da251b5ea35
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN1A SCN3A STAB1	3.52e-04	162	38	3	96c6e94a10b124a1d25dcd705ec5aaa8609c1089
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c09-GZMK-FOS_l\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TNRC18 ATG2A TRMT61B	3.59e-04	163	38	3	e4077e587895c85bc806be05ff5d451088e39468
ToppCell	LPS-antiTNF-Epithelial_airway-Mes-Epi-like\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KIF24 SCN1A STAB1	3.65e-04	164	38	3	4307b002fb41ddfc7ab8a6bca66a60942c250052
ToppCell	PND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN1A SCN3A STAB1	3.65e-04	164	38	3	7a8e5ef52a8fd2877d59ef0696af8a7af90bbed6
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BLNK SCN2A SCN3A	3.65e-04	164	38	3	6fb2136168f430babfeb81ca7e151ca7a8092ec4
ToppCell	PND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN1A SCN3A STAB1	3.65e-04	164	38	3	5e5bd81414ea2d64f73cdef19a0a78c17bec8c18
ToppCell	PND10-Endothelial-Endothelial_lymphatic\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN1A SCN3A STAB1	3.65e-04	164	38	3	f13b8d9b7f42193f333d9a77571a1dde6bbb48d8
ToppCell	PND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN1A SCN3A STAB1	3.65e-04	164	38	3	4cfc9f92e49f86d3639e018b35b6a60dc62f494a
ToppCell	LPS-antiTNF-Epithelial_airway-Mes-Epi-like-Airway\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KIF24 SCN1A STAB1	3.65e-04	164	38	3	1d84aa5b925f502ee9c5fa39714490f613a58028
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EECs\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MNX1 GCLC SCN3A	3.72e-04	165	38	3	4b4e75ad0eb0a6b00c30a000ec6267e23ba2e496
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FOXP1 SCN2A SCN3A	3.78e-04	166	38	3	6fe8db8d45177a78605681f22e04fa8d0594f2df
ToppCell	E16.5-Endothelial-Endothelial_lymphatic\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ARMCX4 SCN3A STAB1	3.85e-04	167	38	3	b93103a868fba63a8910bffb690a6242b9252833
ToppCell	E16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ARMCX4 SCN3A STAB1	3.85e-04	167	38	3	26cd8ee5e826e71eaf58d10a906543a6932fb3f9
ToppCell	E16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ARMCX4 SCN3A STAB1	3.85e-04	167	38	3	fcd583b1efd0ac883379982ea8e6c54f2c0be268
ToppCell	E16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ARMCX4 SCN3A STAB1	3.85e-04	167	38	3	f6bc63138b7239211fa5f27a8dc799b6e022c0f8
ToppCell	droplet-Bladder-BLADDER-1m-Epithelial-basal_bladder_epithelial_cell_(Krt5+Krt14+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KMT2B GCLC KIF24	3.92e-04	168	38	3	ca65321259711321c175ede67bd67a47aad81d7a
ToppCell	PND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN1A SCN3A STAB1	3.99e-04	169	38	3	f077e39e41fffe7672541f5b72b80faaf56c597c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BLNK SCN2A SCN3A	3.99e-04	169	38	3	0332f539a2f7d6dcd081a5d2f567290721f5a329
ToppCell	PND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN1A SCN3A STAB1	4.06e-04	170	38	3	35e3945d8a540a3e2cec1b559316265aaad023d1
ToppCell	Control-Epithelial_cells-ECM-high_epithelial\|Control / group, cell type (main and fine annotations)	ARHGEF12 TACC1 SNX25	4.06e-04	170	38	3	e2023d66e70983c87dacbd6181d3426488d1fc57
ToppCell	Immune_cells-Dendritic_cells\|World / Lineage and Cell class	BLNK GBP4 SCN3A	4.06e-04	170	38	3	094dc211d80c89ecb1010855f1fe6eeb71bf0e20
ToppCell	10x5'v1-week_17-19-Hematopoietic-HSC/MPP_and_pro-ELP\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	BLNK GBP4 SCN3A	4.06e-04	170	38	3	a50e558d0b38100ccbdccb90647fe93e85bffd86
ToppCell	PND01-Endothelial-Endothelial_lymphatic\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN1A SCN3A STAB1	4.06e-04	170	38	3	0ea625abaa25bab93b70b7000e8f90d5c0f9a0fb
ToppCell	PND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN1A SCN3A STAB1	4.06e-04	170	38	3	0b5ddc7d452db0a389927a367914f7d257703f7e
ToppCell	facs\|World / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FADS2 SP100 KMT2B	4.13e-04	171	38	3	5bcb96ed7fc15548f2dc9cf47482f890640cb39c
ToppCell	facs\|World / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SP100 TACC1 KMT2B	4.13e-04	171	38	3	c9990bc041a632b2f7bbebbfe737772c423d7027
ToppCell	facs\|World / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FADS2 SP100 KMT2B	4.13e-04	171	38	3	bb71e816dde44fda6af0ad98d979be9f8740fda6
ToppCell	droplet-Liver-Npc-18m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BLNK FOXP1 FCHO1	4.13e-04	171	38	3	584a095ddcbf78aa29527f84b46b5ad3e2edbaa9
ToppCell	facs-Heart-RV-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BLNK FCHO1 SNX25	4.20e-04	172	38	3	2dcc9d67d6ecc35940eabbc8ed528f5f884f6976
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	BLNK FOXP1 SCN3A	4.20e-04	172	38	3	62ed3b70fa1f6c84ea80ff00f60d2562be292e9d
ToppCell	facs-Heart-RV-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BLNK FCHO1 SNX25	4.20e-04	172	38	3	64d2edbd8e2640b76225597883b1a524e6b1dd3b
ToppCell	droplet-Marrow-nan-24m-Hematologic-erythroid_progenitor\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BLNK FOXP1 SP100	4.20e-04	172	38	3	910ec7794ea4000db4ef1e2c34e08dbc0243df2c
ToppCell	PND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BLNK SP100 FCHO1	4.20e-04	172	38	3	3784fd1e833703519889942e39fda991f03c3c76
ToppCell	PND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BLNK SP100 FCHO1	4.20e-04	172	38	3	995139aa38f8b9ff23166128b15476cd8a3ff1b8
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_progenitors-Cycling_pre-Myeloid-2\|lymph-node_spleen / Manually curated celltypes from each tissue	DMXL2 KIAA0930 STAB1	4.27e-04	173	38	3	783b8fa08b9d8f597f251793eae164151662f1f9
ToppCell	droplet-Large_Intestine-COLON:P+D-30m-Hematologic\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SP100 DMXL2 GBP4	4.27e-04	173	38	3	cd635751f999e12b14c0accfa1c4c1fd3c1d4540
ToppCell	droplet-Large_Intestine-COLON:P+D-30m-Hematologic-hematopoietic_stem_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SP100 DMXL2 GBP4	4.27e-04	173	38	3	7456a417c5c1d4ba25f9489065aae322421308a6
ToppCell	droplet-Large_Intestine-COLON:P+D-30m-Hematologic-hematopoietic_stem_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SP100 DMXL2 GBP4	4.27e-04	173	38	3	35586a9e5f15b41609b6224e33eb3aa3cb7e03b7
ToppCell	ASK452-Immune-B_cell\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	UBL7 RAD9B STAB1	4.34e-04	174	38	3	69723f5666abc3af5f0431901a60246c9915ef81
ToppCell	facs\|World / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FADS2 SP100 KMT2B	4.41e-04	175	38	3	53e96956019f984decc1c81376ebc88fbf3c4d40
Drug	APETx1, Anthopleura elegantissima	SCN2A SCN3A SCN8A	8.55e-08	6	38	3	ctd:C475726
Drug	2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate	SCN2A SCN3A SCN8A	2.39e-07	8	38	3	ctd:C489827
Drug	Zonisamide	SCN1A SCN2A SCN3A	2.87e-06	17	38	3	DB00909
Drug	decamethrin	GCLC SCN1A SCN2A SCN3A SCN8A	4.28e-06	146	38	5	ctd:C017180
Drug	APETx2 protein, Anthopleura elegantissima	SCN2A SCN8A	1.62e-05	4	38	2	ctd:C501880
Drug	carmustine; Up 200; 100uM; MCF7; HT_HG-U133A	SIK2 SP100 DMXL2 ATG2A KMT2B	1.79e-05	196	38	5	6888_UP
Drug	Pilocarpine nitrate [148-72-1]; Down 200; 14.8uM; MCF7; HT_HG-U133A	SIK2 SP100 KMT2B FCHO1 CARD8	1.83e-05	197	38	5	5341_DN
Drug	Pargyline hydrochloride [306-07-0]; Up 200; 20.4uM; MCF7; HT_HG-U133A	SIK2 SP100 KIAA0930 KMT2B ASH1L	1.93e-05	199	38	5	7016_UP
Drug	Natamycin [7681-93-8]; Down 200; 6uM; MCF7; HT_HG-U133A	ARHGEF12 TACC1 KMT2B GCLC FCHO1	1.97e-05	200	38	5	7167_DN
Drug	fenpropathrin	SCN2A SCN3A	4.05e-05	6	38	2	ctd:C044267
Drug	Tetrodotoxin	SCN2A SCN3A SCN8A	4.06e-05	40	38	3	ctd:D013779
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN1A SCN2A SCN3A SCN8A	4.37e-10	10	37	4	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN1A SCN2A SCN3A SCN8A	4.37e-10	10	37	4	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN1A SCN2A SCN3A SCN8A	1.03e-09	12	37	4	DOID:0060170 (implicated_via_orthology)
Disease	Neurodevelopmental Disorders	FOXP1 SCN1A SCN2A SCN8A ASH1L	1.12e-07	93	37	5	C1535926
Disease	anxiety disorder (implicated_via_orthology)	SCN1A SCN2A SCN3A	2.75e-06	22	37	3	DOID:2030 (implicated_via_orthology)
Disease	Benign familial infantile epilepsy	SCN2A SCN8A	4.59e-06	3	37	2	cv:C5575231
Disease	cholesteryl ester 14:0 measurement	FADS2 CARD8 SCN3A	5.20e-06	27	37	3	EFO_0010340
Disease	Familial benign neonatal epilepsy	SCN2A SCN8A	2.29e-05	6	37	2	C0220669
Disease	Bipolar Disorder	NPAS3 FADS2 PLA2G4A SCN2A SCN8A STAB1	2.63e-05	477	37	6	C0005586
Disease	Seizure, Febrile, Simple	SCN1A SCN2A	3.20e-05	7	37	2	C0149886
Disease	Seizure, Febrile, Complex	SCN1A SCN2A	3.20e-05	7	37	2	C0751057
Disease	epilepsy (implicated_via_orthology)	SCN1A SCN2A SCN3A SCN8A	5.14e-05	163	37	4	DOID:1826 (implicated_via_orthology)
Disease	Febrile Convulsions	SCN1A SCN2A	5.48e-05	9	37	2	C0009952
Disease	Generalized Epilepsy with Febrile Seizures Plus	SCN1A SCN2A	5.48e-05	9	37	2	C3502809
Disease	Infantile Severe Myoclonic Epilepsy	SCN1A SCN2A	1.18e-04	13	37	2	C0751122
Disease	Manic	FADS2 SCN2A STAB1	1.29e-04	78	37	3	C0338831
Disease	Epilepsy, Cryptogenic	SCN1A SCN2A SCN8A	1.50e-04	82	37	3	C0086237
Disease	Awakening Epilepsy	SCN1A SCN2A SCN8A	1.50e-04	82	37	3	C0751111
Disease	Aura	SCN1A SCN2A SCN8A	1.50e-04	82	37	3	C0236018
Disease	MMR-related febrile seizures	SCN1A SCN2A	1.59e-04	15	37	2	EFO_0006519
Disease	Early infantile epileptic encephalopathy with suppression bursts	SCN1A SCN2A	1.82e-04	16	37	2	C0393706
Disease	Intellectual Disability	POU3F3 SCN1A SCN3A SCN8A ASH1L	2.28e-04	447	37	5	C3714756
Disease	Febrile seizure (within the age range of 3 months to 6 years)	SCN1A SCN2A	2.31e-04	18	37	2	HP_0002373
Disease	eosinophil percentage of leukocytes	UBL7 SIK2 FADS2 FOXP1 PRKDC KMT2B	3.05e-04	746	37	6	EFO_0007991
Disease	gestational age, birth measurement	NPAS3 FADS2	3.16e-04	21	37	2	EFO_0005112, EFO_0006921
Disease	Epilepsy	SCN1A SCN2A SCN8A	3.48e-04	109	37	3	C0014544
Disease	cortical thickness	ARHGEF12 FADS2 FOXP1 POU3F3 TACC1 KMT2B STAB1	4.07e-04	1113	37	7	EFO_0004840
Disease	Neonatal diabetes mellitus	MNX1 PTF1A	4.51e-04	25	37	2	C0158981
Disease	autism spectrum disorder (implicated_via_orthology)	SCN1A SCN2A ASH1L	9.16e-04	152	37	3	DOID:0060041 (implicated_via_orthology)
Disease	skin microbiome measurement	NPAS3 CARD8	1.10e-03	39	37	2	EFO_0801228
Disease	epilepsy	PLA2G4A SCN1A	1.22e-03	41	37	2	EFO_0000474
Disease	executive function measurement	NPAS3 DMXL2 CARD8 STAB1	1.23e-03	376	37	4	EFO_0009332

Protein segments in the cluster

Peptide	Gene	Start	Entry
SEGSYHFDPDNFDES	TACC1	411	O75410
SDNHRSSSDFFESED	ASH1L	926	Q9NR48
IHSDEEDDAFFSDTQ	DMXL2	2481	Q8TDJ6
FAHQSEASFPVEDES	ARMCX4	2001	Q5H9R4
DSDSDDEDAHFFSVG	ATG2A	891	Q2TAZ0
FFDAREAHSDENPSE	ARHGEF12	1381	Q9NZN5
GTSDADLFDSHDDRD	OSBPL9	346	Q96SU4
HPFDSLARASDSEED	RAD9B	391	Q6WBX8
EDATDAFRAFHPDLE	FADS2	66	O95864
RFSSSDSDFDDEEPR	FCHO1	341	O14526
DEDDEDHFPYSNGAS	MNX1	361	P50219
KSHSANDSEEFFRED	KIAA0930	321	Q6ICG6
NHSPDFDHDRDYEDE	FOXP1	656	Q9H334
FTEDDEASRASKPDH	GCLC	221	P48506
EELDDSDFSEDSFSH	KIF24	821	Q5T7B8
DEAEDSSEFASFFPD	GBP4	176	Q96PP9
EEFQGFHSDEDVAPS	KMT2B	121	Q9UMN6
FDEDDFFTDQSSRDP	PTF1A	21	Q7RTS3
DDFDSDYENPDEHSD	BLNK	66	Q8WV28
DDFDAASLDHEPCAS	FRMPD3	611	Q5JV73
SHFFQEDDETEAEPL	CARD8	86	Q9Y2G2
HSDEDTPTSDDLEQF	POU3F3	311	P20264
PLSDFATQDSFDDDE	PLA2G4A	506	P47712
RDFFSHQEEETEEDS	SNX25	651	Q9H3E2
EAEEDPAHAFEAFQS	SIK2	461	Q9H0K1
SNPDSRDSDDSFEHS	NPAS3	521	Q8IXF0
RDSDDSFEHSDFENP	NPAS3	526	Q8IXF0
NDFADDEHSTFEDSE	SCN3A	591	Q9NY46
SENDFADDEHSTFED	SCN1A	586	P35498
ADDEHSTFEDNESRR	SCN1A	591	P35498
DSENSSEEEFFDAHE	PITPNM1	341	O00562
FEPNQDSSFSEDEHL	TNRC18	2121	O15417
LFQEDDHEESHSDFP	TRMT61B	431	Q9BVS5
GQDHDFSESSEEEAP	SP100	401	P23497
DEHSTFEDNDSRRDS	SCN2A	596	Q99250
FEGLSDDEDDFHPNT	UBL7	226	Q96S82
VFHTDQDDPSSSDDE	WDR44	461	Q5JSH3
DPGSENEFADDEHST	SCN8A	576	Q9UQD0
SAFQAEDDADDDFSP	STAB1	2511	Q9NY15
HDNYRDPESETDNDS	PRKDC	2481	P78527