Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	ConA-like_dom	TRIM72 CNTNAP3B BTN3A3 LGALSL CNTNAP3 LGALS12	1.70e-04	219	70	6	IPR013320
Domain	PRY	TRIM72 BTN3A3 BTN2A3P	7.73e-04	48	70	3	SM00589
Domain	PRY	TRIM72 BTN3A3 BTN2A3P	7.73e-04	48	70	3	IPR006574
Domain	Ferritin-like_SF	CFAP206 RRM2	1.22e-03	14	70	2	IPR009078
Domain	Gal-bind_lectin	LGALSL LGALS12	1.41e-03	15	70	2	PF00337
Domain	Gal-bind_lectin	LGALSL LGALS12	1.41e-03	15	70	2	SM00908
Domain	GALECTIN	LGALSL LGALS12	1.41e-03	15	70	2	PS51304
Domain	Galectin_CRD	LGALSL LGALS12	1.41e-03	15	70	2	IPR001079
Domain	GLECT	LGALSL LGALS12	1.41e-03	15	70	2	SM00276
Domain	AAA+_ATPase	DNAH12 ABCB10 CHTF18 GPN1	2.10e-03	144	70	4	IPR003593
Domain	AAA	DNAH12 ABCB10 CHTF18 GPN1	2.10e-03	144	70	4	SM00382
Domain	Butyrophylin	TRIM72 BTN3A3 BTN2A3P	2.31e-03	70	70	3	IPR003879
Domain	EGF_1	CNTNAP3B FN1 HMCN1 CNTNAP3 PTGS2	2.68e-03	255	70	5	PS00022
Domain	FA58C	CNTNAP3B CNTNAP3	2.78e-03	21	70	2	SM00231
Domain	FA58C_3	CNTNAP3B CNTNAP3	2.78e-03	21	70	2	PS50022
Domain	FA58C_1	CNTNAP3B CNTNAP3	2.78e-03	21	70	2	PS01285
Domain	FA58C_2	CNTNAP3B CNTNAP3	2.78e-03	21	70	2	PS01286
Domain	IGv	BTN3A3 HMCN1 BTN2A3P	2.81e-03	75	70	3	SM00406
Domain	F5_F8_type_C	CNTNAP3B CNTNAP3	3.62e-03	24	70	2	PF00754
Domain	FA58C	CNTNAP3B CNTNAP3	3.62e-03	24	70	2	IPR000421
Domain	SPRY	TRIM72 BTN3A3 BTN2A3P	4.27e-03	87	70	3	SM00449
Domain	SPRY	TRIM72 BTN3A3 BTN2A3P	5.30e-03	94	70	3	PF00622
Domain	SPRY_dom	TRIM72 BTN3A3 BTN2A3P	5.30e-03	94	70	3	IPR003877
Domain	B30.2/SPRY	TRIM72 BTN3A3 BTN2A3P	5.46e-03	95	70	3	IPR001870
Domain	B302_SPRY	TRIM72 BTN3A3 BTN2A3P	5.46e-03	95	70	3	PS50188
Domain	-	LGALSL CNTNAP3 LGALS12	5.46e-03	95	70	3	2.60.120.200
Domain	FIBRINOGEN_C_1	CNTNAP3B CNTNAP3	6.39e-03	32	70	2	PS00514
Domain	Fibrinogen_a/b/g_C_dom	CNTNAP3B CNTNAP3	6.39e-03	32	70	2	IPR002181
Domain	FIBRINOGEN_C_2	CNTNAP3B CNTNAP3	6.39e-03	32	70	2	PS51406
Pathway	WP_OVERVIEW_OF_NANOPARTICLE_EFFECTS	FN1 HMOX1 PTGS2	3.24e-05	19	47	3	M39473
Pubmed	Effects of estrogen on endothelial prostanoid production and cyclooxygenase-2 and heme oxygenase-1 expression.	HMOX1 PTGS2	4.23e-06	2	72	2	22330859
Pubmed	NS398 protects cells from sodium nitroprusside-mediated cytotoxicity through enhancing HO-1 induction independent of COX-2 inhibition.	HMOX1 PTGS2	4.23e-06	2	72	2	19183882
Pubmed	The critical role of ASD-related gene CNTNAP3 in regulating synaptic development and social behavior in mice.	CNTNAP3B CNTNAP3	4.23e-06	2	72	2	31150793
Pubmed	Induction of HO-1 by carbon monoxide releasing molecule-2 attenuates thrombin-induced COX-2 expression and hypertrophy in primary human cardiomyocytes.	HMOX1 PTGS2	4.23e-06	2	72	2	26385185
Pubmed	NMDA receptor-dependent prostaglandin-endoperoxide synthase 2 induction in neurons promotes glial proliferation during brain development and injury.	GRIN2A PTGS2	4.23e-06	2	72	2	35354047
Pubmed	Caspr3-Deficient Mice Exhibit Low Motor Learning during the Early Phase of the Accelerated Rotarod Task.	CNTNAP3B CNTNAP3	4.23e-06	2	72	2	26807827
Pubmed	Mycoplasma fermentans MALP-2 induces heme oxygenase-1 expression via mitogen-activated protein kinases and Nrf2 pathways to modulate cyclooxygenase 2 expression in human monocytes.	HMOX1 PTGS2	4.23e-06	2	72	2	23536693
Pubmed	Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1.	FN1 DCHS1	4.21e-05	5	72	2	16061471
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	TPP1 CHTF18 L2HGDH PAM PZP ANKZF1 ADCY6 WDR48	5.96e-05	650	72	8	38777146
Pubmed	BTN1A1, the mammary gland butyrophilin, and BTN2A2 are both inhibitors of T cell activation.	BTN3A3 BTN2A3P	6.31e-05	6	72	2	20208008
Pubmed	In trans neuregulin3-Caspr3 interaction controls DA axonal bassoon cluster development.	CNTNAP3B CNTNAP3	6.31e-05	6	72	2	34143959
Pubmed	The cluster of BTN genes in the extended major histocompatibility complex.	BTN3A3 BTN2A3P	8.82e-05	7	72	2	11170752
Pubmed	Dachsous1-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis-Brief Report.	FN1 DCHS1	1.51e-04	9	72	2	28705793
Pubmed	Human immunodeficiency virus type 1 clade B and C gp120 differentially induce neurotoxin arachidonic acid in human astrocytes: implications for neuroAIDS.	GRIN2A PTGS2	1.51e-04	9	72	2	21491143
Pubmed	Examination of association with candidate genes for diabetic nephropathy in a Mexican American population.	HMCN1 HMOX1	1.51e-04	9	72	2	20299368
Pubmed	Binding of neuroligins to PSD-95.	NLGN2 GRIN2A	1.51e-04	9	72	2	9278515
Pubmed	Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase.	GRIN2A PTGS2	2.30e-04	11	72	2	8581564
Pubmed	Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method.	FN1 PAM	2.30e-04	11	72	2	8938438
Pubmed	CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins.	NLGN2 GRIN2A	2.30e-04	11	72	2	9647694
Pubmed	Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy.	HMOX1 PTGS2	3.25e-04	13	72	2	34188052
Pubmed	Epithelial-Macrophage Crosstalk Initiates Sterile Inflammation in Embryonic Skin.	FN1 PTGS2	4.36e-04	15	72	2	34721382
Pubmed	Head bobber: an insertional mutation causes inner ear defects, hyperactive circling, and deafness.	FN1 HMX3	4.36e-04	15	72	2	22383091
Pubmed	Cyclin F Controls Cell-Cycle Transcriptional Outputs by Directing the Degradation of the Three Activator E2Fs.	FBXO3 RRM2	5.63e-04	17	72	2	31130363
Pubmed	Cell adhesion molecule contactin-associated protein 3 is expressed in the mouse basal ganglia during early postnatal stages.	CNTNAP3B CNTNAP3	5.63e-04	17	72	2	26389685
Pubmed	Docking motif-guided mapping of the interactome of protein phosphatase-1.	PKMYT1 ZSWIM3 SACS	6.23e-04	80	72	3	19389623
Pubmed	IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α.	NLGN2 GRIN2A	6.33e-04	18	72	2	28864826
Pubmed	A mouse model of Townes-Brocks syndrome expressing a truncated mutant Sall1 protein is protected from acute kidney injury.	HMOX1 PTGS2	7.84e-04	20	72	2	26311113
Pubmed	Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair.	FBXO3 RRM2	7.84e-04	20	72	2	22632967
Pubmed	Rapid identification of 14-3-3-binding proteins by protein microarray analysis.	NAF1 ANKZF1	8.65e-04	21	72	2	16260042
Pubmed	Identification of type 2 diabetes-associated combination of SNPs using support vector machine.	RAPGEF1 HMOX1 PTGS2	9.07e-04	91	72	3	20416077
Pubmed	Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.	SEC24A BCKDHB RRM2 PTGS2	9.47e-04	209	72	4	26389662
Pubmed	FoxP1 orchestration of ASD-relevant signaling pathways in the striatum.	CNTNAP3B CNTNAP3	9.50e-04	22	72	2	26494785
Pubmed	Zfhx3 is required for the differentiation of late born D1-type medium spiny neurons.	CNTNAP3B CNTNAP3	1.65e-03	29	72	2	31491374
Pubmed	Cerebellar development transcriptome database (CDT-DB): profiling of spatio-temporal gene expression during the postnatal development of mouse cerebellum.	CCNH GRIN2A	1.77e-03	30	72	2	18603407
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	FN1 PAM NLGN2 GRIN2A TUBAL3	2.00e-03	430	72	5	32581705
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PKMYT1 CLCN7 NAPRT FBRS RAPGEF1 NLGN2 GPC2 SPATA13	2.01e-03	1105	72	8	35748872
Pubmed	FBXO38 Ubiquitin Ligase Controls Centromere Integrity via ZXDA/B Stability.	FBXO42 RRM2	2.01e-03	32	72	2	35813202
Pubmed	Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes.	HMOX1 RRM2 PTGS2	2.06e-03	121	72	3	8827514
Cytoband	11p15	TPP1 OR51B4	2.10e-03	43	72	2	11p15
GeneFamily	Butyrophilins\|V-set domain containing\|C2-set domain containing	BTN3A3 BTN2A3P	5.69e-04	15	43	2	458
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	TRIM72 TRPM5 VGLL2 CFAP206	4.82e-06	69	72	4	4831573a45ace5f06cd409f0e75bce838ed65a88
ToppCell	facs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 ABCB10 TNPO2 PZP ADCY6	6.17e-06	160	72	5	56e6f4b82b5dc41c45f9d253c2db314a6f702b84
ToppCell	facs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 ABCB10 TNPO2 PZP ADCY6	6.17e-06	160	72	5	bb1b966fb9e801db15e67d03e49db4609d6f935a
ToppCell	390C-Myeloid-Dendritic-cDC_proliferating_1\|390C / Donor, Lineage, Cell class and subclass (all cells)	PKMYT1 CHTF18 TMEM145 RRM2 WDFY4	7.82e-06	168	72	5	2082b15fc7935a211f1c61506b305af5501a21ad
Disease	platelet-activating factor measurement	BTN3A3 BTN2A3P	5.68e-05	5	71	2	EFO_0801075
Disease	autosomal recessive intellectual developmental disorder (implicated_via_orthology)	CNTNAP3B CNTNAP3	1.58e-04	8	71	2	DOID:0060308 (implicated_via_orthology)
Disease	Colorectal Carcinoma	FN1 ABCB10 SACS DCHS1 GRIN2A RRM2 PZP PTGS2	2.80e-04	702	71	8	C0009402
Disease	Mammary Neoplasms, Experimental	CCNH FN1 CSN3 HMOX1	5.41e-04	155	71	4	C0024668
Disease	Carcinomatosis	CCNH FN1 CSN3 PTGS2	6.54e-04	163	71	4	C0205699
Disease	Carcinoma, Spindle-Cell	CCNH FN1 CSN3 PTGS2	6.54e-04	163	71	4	C0205697
Disease	Undifferentiated carcinoma	CCNH FN1 CSN3 PTGS2	6.54e-04	163	71	4	C0205698
Disease	Anaplastic carcinoma	CCNH FN1 CSN3 PTGS2	6.54e-04	163	71	4	C0205696
Disease	Carcinoma	CCNH FN1 CSN3 PTGS2	6.69e-04	164	71	4	C0007097
Disease	portal hypertension (implicated_via_orthology)	HMOX1 PTGS2	9.51e-04	19	71	2	DOID:10762 (implicated_via_orthology)
Disease	Colitis	HMOX1 PTGS2	1.65e-03	25	71	2	C0009319
Disease	status epilepticus (biomarker_via_orthology)	NLGN2 GRIN2A HMOX1	1.83e-03	100	71	3	DOID:1824 (biomarker_via_orthology)
Disease	acute kidney failure (implicated_via_orthology)	HMOX1 PTGS2	1.93e-03	27	71	2	DOID:3021 (implicated_via_orthology)
Disease	Hyperplasia	HMOX1 PTGS2	2.07e-03	28	71	2	C0020507
Disease	urinary bladder cancer (is_marker_for)	FN1 RRM2 PTGS2	2.22e-03	107	71	3	DOID:11054 (is_marker_for)
Disease	cytotoxicity measurement, response to clozapine	PKMYT1 HMCN1	2.22e-03	29	71	2	EFO_0006952, GO_0097338
Disease	obstructive sleep apnea (is_marker_for)	HMOX1 PTGS2	2.22e-03	29	71	2	DOID:0050848 (is_marker_for)
Disease	Myocardial Failure	FIP1L1 HMOX1 PTGS2	2.40e-03	110	71	3	C1959583
Disease	Congestive heart failure	FIP1L1 HMOX1 PTGS2	2.40e-03	110	71	3	C0018802
Disease	Heart failure	FIP1L1 HMOX1 PTGS2	2.40e-03	110	71	3	C0018801
Disease	Left-Sided Heart Failure	FIP1L1 HMOX1 PTGS2	2.40e-03	110	71	3	C0023212
Disease	Heart Failure, Right-Sided	FIP1L1 HMOX1 PTGS2	2.40e-03	110	71	3	C0235527
Disease	Heart Decompensation	FIP1L1 HMOX1 PTGS2	2.40e-03	110	71	3	C1961112

Protein segments in the cluster

Peptide	Gene	Start	Entry
YTFPHSAFSVPVRPF	BTN2A3P	441	Q96KV6
RYPPFLPVAFHVLFA	CHTF18	696	Q8WVB6
VVHYRLQPPFEARFL	CNTNAP3	141	Q9BZ76
FHLIVHNPYRPFEGF	CCNH	156	P51946
FPHASFSEPLYPVFR	BTN3A3	486	O00478
PARGFHFVYQAVPRT	CSMD2	1716	Q7Z408
LLAFHAAPARPQPAY	ADCY6	166	O43306
NVHFAYPARPEVPIF	ABCB10	496	Q9NRK6
PQAFYPVGHPVDVSF	PAM	266	P19021
EYNVSVHFPRPEPEA	AMIGO3	366	Q86WK7
PHPPFFEVYRNSESV	DET1	166	Q7L5Y6
QPFLGAHELYFPERV	CFAP206	351	Q8IYR0
PRPFFIHNGAIYVPL	PZP	641	P20742
NDNAPVFPHPIYRVK	PCDHGA8	236	Q9Y5G5
VAHFTFQPDPEPREY	BCKDHB	51	P21953
SPYPLHQPERFFDEI	FBXO42	196	Q6P3S6
FLRPHYVAFLPESRP	DCHS1	2171	Q96JQ0
PVQADVYFPRLIVPF	LGALSL	26	Q3ZCW2
YPVPDSRFPFLGVHF	L2HGDH	301	Q9H9P8
LERVFPLLHPQYSFP	GPC2	171	Q8N158
FEIPAQRFALPAHYL	HMX3	96	A6NHT5
FRDAYPRFPPIQSIH	CLCN7	711	P51798
FPIIRDQIFRYVHDP	FBXO3	261	Q9UK99
AYFIHHRQQFIFPVP	KSR1	491	Q8IVT5
FILQPPVFHPVVPYV	LGALS12	36	Q96DT0
VHFLFPPFVNPIIYS	OR51B4	276	Q9Y5P0
ARAFPYGNVAFPHLP	FIP1L1	421	Q6UN15
LRTHEFPPEYFVIGN	DNAH12	2051	Q6ZR08
YPPQVPEHLRFAVGQ	PTGS2	261	P35354
DIRHPVVNFPPALYE	GNL1	196	P36915
YVINLDPAVHEVPFP	GPN1	51	Q9HCN4
RPLFNFALVPFHDPE	HMCN1	76	Q96RW7
ARSAFPYAHRFPPQT	PPCS	86	Q9HAB8
EPHRFQYPERPIIFL	FZD9	256	O00144
GLFRHNPYTAFPPAV	FBRS	11	Q9HAH7
IPFDEAPHLDPQIFY	CCDC106	21	Q9BWC9
FHVDFEDPARPRVPY	GBA3	436	Q9H227
RPPGFYPHRVLFQNA	ANKZF1	156	Q9H8Y5
FTDVRAAVYQPQPHP	FN1	286	P02751
LHRDPRYFPNPEEFQ	CYP4V2	426	Q6ZWL3
PERFFPENAQGRHPY	CYP4V2	441	Q6ZWL3
IYFLVTHRNPFPFIG	SLC1A6	361	P48664
SPVFAPVYFPEELHR	HMOX1	71	P09601
VPRTYYANPAVVRPH	CSN3	76	P07498
PERAPAEFIRFHPQY	SACS	3656	Q9NZJ4
DVQPARYHIAFGPVV	NLGN2	341	Q8NFZ4
VVHYRLQPPFEARFL	CNTNAP3B	141	Q96NU0
EPLYGFHAQEFIPFR	TAF6	81	P49848
EAVNALRPFYFAVHP	TCAIM	31	Q8N3R3
IFVRPYHVPFIRDVA	SYNJ2	636	O15056
QYIDVSHVFPEFPAP	RFX2	336	P48378
PQPPVYLFVFDVSHN	SEC24A	501	O95486
EFQTNLVPYPRIHFP	TUBAL3	261	A6NHL2
PAHQVPPYKAVSARF	SPATA13	56	Q96N96
YFQVPPHTPVIFGEA	WDR48	506	Q8TAF3
APSFHVDVPVQFDIY	TRAPPC11	596	Q7Z392
AQAAPYPRPAAVHEV	VGLL2	216	Q8N8G2
IVEYHERPALAPPFI	TRPM5	1001	Q9NZQ8
SVPYAPFAAILPFQH	RAPGEF1	501	Q13905
IPVPAYFRHAEPGFS	PKMYT1	26	Q99640
NPRRFVIFPIEYHDI	RRM2	76	P31350
AHYQSFPPPVADFIK	TNPO2	76	O14787
GPAAVDAVNIFHPYF	WDFY4	2766	Q6ZS81
VQEPHPGERAAFVAY	NAPRT	261	Q6XQN6
VPLFAFHERLPRPVY	TRIM72	436	Q6ZMU5
FHERLPRPVYPFFDV	TRIM72	441	Q6ZMU5
NFFQGLPVVRHPLPY	NIPAL4	251	Q0D2K0
PSFHYRAILQEIFPA	ZSWIM3	286	Q96MP5
LLVFQYAARHPETFP	VSIG10L2	721	P0DP72
VSLRHFPEKQPFYVP	TMEM145	336	Q8NBT3
RHQFRPTFPASSPYV	TPP1	371	O14773
GVNFFELPPHVYAIA	MYO1H	71	Q8N1T3
FEIFGPVAHPFYVLR	NAF1	241	Q96HR8
QRPHDYSPPFRFGTV	GRIN2A	671	Q12879