Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	BMP receptor binding	BMP4 BMP5 BMP6 BMP7	1.71e-06	13	143	4	GO:0070700
GeneOntologyMolecularFunction	transmembrane receptor protein serine/threonine kinase binding	BMP4 BMP5 BMP6 BMP7	3.89e-05	27	143	4	GO:0070696
GeneOntologyMolecularFunction	receptor serine/threonine kinase binding	BMP4 BMP5 BMP6 BMP7	1.11e-04	35	143	4	GO:0033612
GeneOntologyBiologicalProcess	cartilage development	POR RELA BMP4 BMP5 BMP6 BMP7 THBS3 PKD1 FGFR3 GNAS	6.04e-06	243	139	10	GO:0051216
GeneOntologyBiologicalProcess	endochondral bone morphogenesis	POR BMP4 BMP6 THBS3 FGFR3 GNAS	1.56e-05	79	139	6	GO:0060350
GeneOntologyBiologicalProcess	bone morphogenesis	TIFAB POR BMP4 BMP6 THBS3 FGFR3 GNAS	2.12e-05	124	139	7	GO:0060349
GeneOntologyBiologicalProcess	negative regulation of miRNA transcription	RELA NCOR1 BMP4 NCOR2	5.40e-05	31	139	4	GO:1902894
GeneOntologyBiologicalProcess	neural crest cell migration	NRTN BMP4 BMP7 RADIL SEMA5B	6.15e-05	62	139	5	GO:0001755
GeneOntologyBiologicalProcess	positive regulation of epithelial to mesenchymal transition	ADAM8 BMP4 BMP7 MTOR AGER	6.64e-05	63	139	5	GO:0010718
GeneOntologyBiologicalProcess	mesenchymal cell migration	NRTN BMP4 BMP7 RADIL SEMA5B	7.16e-05	64	139	5	GO:0090497
GeneOntologyBiologicalProcess	negative regulation of miRNA metabolic process	RELA NCOR1 BMP4 NCOR2	7.83e-05	34	139	4	GO:2000629
GeneOntologyBiologicalProcess	mineralocorticoid biosynthetic process	CYP21A2 BMP5 BMP6	8.15e-05	13	139	3	GO:0006705
GeneOntologyBiologicalProcess	lateral sprouting from an epithelium	BMP4 BMP7 CELSR1	8.15e-05	13	139	3	GO:0060601
GeneOntologyBiologicalProcess	dendrite development	SHANK1 DHX36 CACNA1F SPIRE1 BMP5 BMP7 CYFIP1 MTOR IQSEC1 ARHGAP33	9.35e-05	335	139	10	GO:0016358
GeneOntologyBiologicalProcess	positive regulation of cartilage development	POR RELA BMP4 BMP6	9.84e-05	36	139	4	GO:0061036
GeneOntologyBiologicalProcess	skeletal system morphogenesis	TIFAB POR BMP4 BMP6 BMP7 THBS3 PKD1 FGFR3 GNAS	1.12e-04	277	139	9	GO:0048705
GeneOntologyBiologicalProcess	connective tissue development	POR RELA BMP4 BMP5 BMP6 BMP7 THBS3 PKD1 FGFR3 GNAS	1.13e-04	343	139	10	GO:0061448
GeneOntologyBiologicalProcess	neural fold elevation formation	BMP5 BMP7	1.35e-04	3	139	2	GO:0021502
GeneOntologyBiologicalProcess	positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis	BMP4 BMP7	1.35e-04	3	139	2	GO:1905312
GeneOntologyBiologicalProcess	primary neural tube formation	PTK7 BMP4 BMP5 BMP7 CELSR1 KDM2B	1.64e-04	120	139	6	GO:0014020
GeneOntologyBiologicalProcess	mesenchymal cell differentiation	NRTN ADAM8 BMP4 BMP5 BMP7 RADIL SEMA5B MTOR AGER	1.84e-04	296	139	9	GO:0048762
GeneOntologyBiologicalProcess	mineralocorticoid metabolic process	CYP21A2 BMP5 BMP6	1.90e-04	17	139	3	GO:0008212
GeneOntologyBiologicalProcess	replacement ossification	BMP4 BMP6 FGFR3 GNAS	1.99e-04	43	139	4	GO:0036075
GeneOntologyBiologicalProcess	positive regulation of SMAD protein signal transduction	BMP4 BMP5 BMP6 BMP7	1.99e-04	43	139	4	GO:0060391
GeneOntologyBiologicalProcess	endochondral ossification	BMP4 BMP6 FGFR3 GNAS	1.99e-04	43	139	4	GO:0001958
GeneOntologyBiologicalProcess	mesenchyme development	NRTN ADAM8 PTK7 BMP4 BMP5 BMP7 RADIL SEMA5B MTOR AGER	2.19e-04	372	139	10	GO:0060485
GeneOntologyBiologicalProcess	regulation of epithelial to mesenchymal transition	ADAM8 BMP4 BMP5 BMP7 MTOR AGER	2.53e-04	130	139	6	GO:0010717
GeneOntologyBiologicalProcess	regulation of microtubule nucleation	HAUS5 HAUS4 PDE4DIP	2.68e-04	19	139	3	GO:0010968
GeneOntologyBiologicalProcess	regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis	BMP4 BMP7	2.68e-04	4	139	2	GO:1905310
GeneOntologyBiologicalProcess	negative regulation of prostatic bud formation	BMP4 BMP7	2.68e-04	4	139	2	GO:0060686
GeneOntologyBiologicalProcess	allantois development	BMP5 BMP7	2.68e-04	4	139	2	GO:1905069
GeneOntologyBiologicalProcess	neural tube formation	PTK7 BMP4 BMP5 BMP7 CELSR1 KDM2B	2.98e-04	134	139	6	GO:0001841
GeneOntologyBiologicalProcess	regulation of ketone metabolic process	BCKDK TYSND1 NCOR1 NCOR2 BMP5 BMP6 MTOR	2.99e-04	189	139	7	GO:0010565
GeneOntologyBiologicalProcess	positive regulation of osteoblast differentiation	BMP4 BMP6 BMP7 LRP3 GNAS	3.23e-04	88	139	5	GO:0045669
GeneOntologyBiologicalProcess	positive regulation of bone mineralization	BMP4 BMP6 BMP7 FGFR3	3.31e-04	49	139	4	GO:0030501
GeneOntologyBiologicalProcess	neural crest cell development	NRTN BMP4 BMP7 RADIL SEMA5B	3.41e-04	89	139	5	GO:0014032
GeneOntologyBiologicalProcess	response to muramyl dipeptide	NLRP1 RELA NOD2	3.64e-04	21	139	3	GO:0032495
GeneOntologyBiologicalProcess	dendritic spine development	SHANK1 DHX36 SPIRE1 MTOR IQSEC1 ARHGAP33	3.91e-04	141	139	6	GO:0060996
GeneOntologyBiologicalProcess	positive regulation of dendrite development	BMP5 BMP7 CYFIP1	4.20e-04	22	139	3	GO:1900006
GeneOntologyBiologicalProcess	negative regulation of glomerular mesangial cell proliferation	BMP4 BMP7	4.45e-04	5	139	2	GO:0072125
GeneOntologyBiologicalProcess	protein polymerization	HAUS5 SPIRE1 TUBGCP6 SPTBN5 HAUS4 CYFIP1 MTOR PDE4DIP HCLS1	4.46e-04	334	139	9	GO:0051258
GeneOntologyBiologicalProcess	regulation of steroid hormone biosynthetic process	POR BMP5 BMP6	5.46e-04	24	139	3	GO:0090030
GeneOntologyBiologicalProcess	positive regulation of chondrocyte differentiation	POR RELA BMP6	5.46e-04	24	139	3	GO:0032332
GeneOntologyBiologicalProcess	microtubule nucleation	HAUS5 TUBGCP6 HAUS4 PDE4DIP	5.91e-04	57	139	4	GO:0007020
GeneOntologyBiologicalProcess	trabecula morphogenesis	BMP5 BMP7 THBS3 FGFR3	5.91e-04	57	139	4	GO:0061383
GeneOntologyBiologicalProcess	stem cell development	NRTN BMP4 BMP7 RADIL SEMA5B	6.10e-04	101	139	5	GO:0048864
GeneOntologyBiologicalProcess	ketone metabolic process	CYP21A2 BCKDK TYSND1 NCOR1 NCOR2 BMP5 BMP6 MTOR	6.20e-04	279	139	8	GO:0042180
GeneOntologyBiologicalProcess	regulation of prostatic bud formation	BMP4 BMP7	6.64e-04	6	139	2	GO:0060685
GeneOntologyBiologicalProcess	regulation of branching involved in prostate gland morphogenesis	BMP4 BMP7	6.64e-04	6	139	2	GO:0060687
GeneOntologyBiologicalProcess	regulation of chondrocyte differentiation	POR RELA BMP4 BMP6	6.74e-04	59	139	4	GO:0032330
GeneOntologyBiologicalProcess	C21-steroid hormone biosynthetic process	CYP21A2 BMP5 BMP6	6.95e-04	26	139	3	GO:0006700
GeneOntologyBiologicalProcess	neural crest cell differentiation	NRTN BMP4 BMP7 RADIL SEMA5B	6.97e-04	104	139	5	GO:0014033
Domain	TGF-b_C	NRTN GDF1 BMP4 BMP5 BMP6 BMP7	2.93e-07	37	139	6	IPR001839
Domain	TGF_BETA_1	NRTN GDF1 BMP4 BMP5 BMP6 BMP7	2.93e-07	37	139	6	PS00250
Domain	TGFB	NRTN GDF1 BMP4 BMP5 BMP6 BMP7	2.93e-07	37	139	6	SM00204
Domain	TGF_BETA_2	NRTN GDF1 BMP4 BMP5 BMP6 BMP7	2.93e-07	37	139	6	PS51362
Domain	TGF_beta	NRTN GDF1 BMP4 BMP5 BMP6 BMP7	2.93e-07	37	139	6	PF00019
Domain	TGFb_propeptide	GDF1 BMP4 BMP5 BMP6 BMP7	1.82e-06	28	139	5	PF00688
Domain	TGF-b_N	GDF1 BMP4 BMP5 BMP6 BMP7	1.82e-06	28	139	5	IPR001111
Domain	TGF-beta-rel	GDF1 BMP4 BMP5 BMP6 BMP7	3.64e-06	32	139	5	IPR015615
Domain	TGFb_CS	GDF1 BMP4 BMP5 BMP6 BMP7	3.64e-06	32	139	5	IPR017948
Domain	-	NRTN GDF1 BMP4 BMP5 BMP6 BMP7	1.05e-05	67	139	6	2.10.90.10
Domain	Cystine-knot_cytokine	NRTN GDF1 BMP4 BMP5 BMP6 BMP7	1.05e-05	67	139	6	IPR029034
Domain	N-CoR_GPS2_interact	NCOR1 NCOR2	5.50e-05	2	139	2	IPR031557
Domain	GPS2_interact	NCOR1 NCOR2	5.50e-05	2	139	2	PF15784
Domain	KIND_dom	SPIRE1 PTPN13	5.42e-04	5	139	2	IPR011019
Domain	KIND	SPIRE1 PTPN13	5.42e-04	5	139	2	SM00750
Domain	KIND	SPIRE1 PTPN13	5.42e-04	5	139	2	PS51377
Pathway	KEGG_MEDICUS_REFERENCE_BMP_SIGNALING_PATHWAY_BMP_ANTAGONIST	BMP4 BMP5 BMP6 BMP7	2.60e-06	15	96	4	M47824
Pathway	KEGG_MEDICUS_REFERENCE_BMP_SIGNALING_PATHWAY	BMP4 BMP5 BMP6 BMP7	9.00e-06	20	96	4	M47843
Pathway	WP_DEVELOPMENT_OF_URETERIC_COLLECTION_SYSTEM	BMP4 BMP5 FREM2 BMP7 CELSR1	5.36e-05	60	96	5	M40048
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DOCK3 CRYBG2 SZT2 SPEG POLG FBRSL1 SPIRE1 NOD2 NCOR1 BMP4 NCOR2 RADIL HAUS4 CELSR1 IGF2R CELSR3 MTOR MCM3AP HPS6 PKD1 LRP3 SNX15 ABCC10 PKN3 ARHGAP33	4.06e-12	1105	143	25	35748872
Pubmed	Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis.	GDF1 BMP4 BMP5 BMP6 BMP7	1.36e-10	9	143	5	1460021
Pubmed	Expression of bone morphogenetic proteins in human metastatic prostate and breast cancer.	BMP4 BMP5 BMP6 BMP7	1.37e-09	5	143	4	15861517
Pubmed	Apoptosis, proliferation and gene expression patterns in mouse developing tongue.	BMP4 BMP5 BMP6 BMP7 FGFR3	1.37e-09	13	143	5	16151852
Pubmed	Bone morphogenetic protein signaling in the developing kidney: present and future.	BMP4 BMP5 BMP6 BMP7	4.08e-09	6	143	4	18331343
Pubmed	Expression patterns of bone morphogenetic proteins (Bmps) in the developing mouse tooth suggest roles in morphogenesis and cell differentiation.	BMP4 BMP5 BMP6 BMP7	4.08e-09	6	143	4	9415424
Pubmed	Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos.	BMP4 BMP5 BMP6 BMP7	4.08e-09	6	143	4	9056639
Pubmed	Osteocyte control of bone formation via sclerostin, a novel BMP antagonist.	BMP4 BMP5 BMP6 BMP7	4.08e-09	6	143	4	14633986
Pubmed	Limbiting outgrowth: BMPs as negative regulators in limb development.	BMP4 BMP5 BMP6 BMP7	9.50e-09	7	143	4	10462412
Pubmed	A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4.	BMP4 BMP5 BMP6 BMP7	9.50e-09	7	143	4	7811286
Pubmed	Neuronal differentiation of precursors in the neocortical ventricular zone is triggered by BMP.	BMP4 BMP5 BMP6 BMP7	9.50e-09	7	143	4	9786991
Pubmed	BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis.	BMP4 BMP5 BMP6 BMP7	9.50e-09	7	143	4	31566563
Pubmed	The enamel knot as a signaling center in the developing mouse tooth.	BMP4 BMP5 BMP6 BMP7	1.89e-08	8	143	4	8808404
Pubmed	Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development.	BMP4 BMP5 BMP6 BMP7	1.89e-08	8	143	4	9187146
Pubmed	Mice lacking Bmp6 function.	BMP4 BMP5 BMP6 BMP7	1.89e-08	8	143	4	9664685
Pubmed	A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage.	BMP4 BMP5 BMP6 BMP7	3.40e-08	9	143	4	14660436
Pubmed	Exploring the effects of gene dosage on mandible shape in mice as a model for studying the genetic basis of natural variation.	BMP4 BMP5 BMP6 BMP7	3.40e-08	9	143	4	23563729
Pubmed	BMP4 substitutes for loss of BMP7 during kidney development.	BMP4 BMP6 BMP7	6.81e-08	3	143	3	16154126
Pubmed	A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7.	BMP5 BMP6 BMP7	6.81e-08	3	143	3	1427904
Pubmed	Immunohistochemical analysis revealed the expression of bone morphogenetic proteins-4, 6, 7, and 9 in human induced membrane samples treated with the Masquelet technique.	BMP4 BMP6 BMP7	6.81e-08	3	143	3	35033126
Pubmed	Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells.	BMP4 BMP5 BMP6	6.81e-08	3	143	3	11865031
Pubmed	Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone.	BMP5 BMP6 BMP7	6.81e-08	3	143	3	2263636
Pubmed	Bone morphogenetic proteins 4, 6, and 7 are up-regulated in mouse spinal cord during experimental autoimmune encephalomyelitis.	BMP4 BMP6 BMP7	6.81e-08	3	143	3	17722066
Pubmed	Bmp7 regulates germ cell proliferation in mouse fetal gonads.	BMP4 BMP5 BMP6 BMP7	1.90e-07	13	143	4	18391523
Pubmed	Immunohistochemical localization of bone morphogenetic proteins (BMPs) 2, 4, 6, and 7 during induced heterotopic bone formation.	BMP4 BMP6 BMP7	2.71e-07	4	143	3	17262821
Pubmed	Skeletal abnormalities in doubly heterozygous Bmp4 and Bmp7 mice.	BMP4 BMP5 BMP7	2.71e-07	4	143	3	9664686
Pubmed	Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation.	BMP4 BMP6 BMP7	2.71e-07	4	143	3	17244894
Pubmed	Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.	NPEPPS PTK7 FREM2 CELSR1 CYFIP1 CELSR3	3.53e-07	67	143	6	21875946
Pubmed	Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells.	BMP4 BMP5 BMP6 BMP7	3.61e-07	15	143	4	15226263
Pubmed	Bmp5/7 in concert with the mid-hindbrain organizer control development of noradrenergic locus coeruleus neurons.	BMP4 BMP5 BMP6 BMP7	4.80e-07	16	143	4	20493948
Pubmed	Neural plate morphogenesis during mouse neurulation is regulated by antagonism of Bmp signalling.	BMP4 BMP5 BMP6 BMP7	6.26e-07	17	143	4	17693602
Pubmed	Bmp7 regulates the survival, proliferation, and neurogenic properties of neural progenitor cells during corticogenesis in the mouse.	BMP4 BMP5 BMP6 BMP7	6.26e-07	17	143	4	22461901
Pubmed	Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot.	BMP4 BMP6 BMP7	6.77e-07	5	143	3	14623234
Pubmed	Histological development and dynamic expression of Bmp2-6 mRNAs in the embryonic and postnatal mouse cranial base.	BMP4 BMP5 BMP6	6.77e-07	5	143	3	17066377
Pubmed	Chromosomal localization, embryonic expression, and imprinting tests for Bmp7 on distal mouse chromosome 2.	BMP5 BMP7 GNAS	6.77e-07	5	143	3	7490098
Pubmed	Bmp6 and Bmp7 are required for cushion formation and septation in the developing mouse heart.	BMP4 BMP6 BMP7	6.77e-07	5	143	3	11437450
Pubmed	Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells.	BMP4 BMP5 BMP6	6.77e-07	5	143	3	15516325
Pubmed	Erythroferrone inhibits the induction of hepcidin by BMP6.	BMP5 BMP6 BMP7	6.77e-07	5	143	3	30097509
Pubmed	Dragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages.	BMP4 BMP5 BMP6 BMP7	1.01e-06	19	143	4	21187450
Pubmed	BMP mRNA and protein expression in the developing mouse olfactory system.	BMP4 BMP6 BMP7	1.35e-06	6	143	3	12210138
Pubmed	Regulation of ovarian function by the TGF-beta superfamily and follistatin.	BMP4 BMP6 BMP7	1.35e-06	6	143	3	12887271
Pubmed	Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development.	BMP5 BMP6 BMP7	1.35e-06	6	143	3	7605753
Pubmed	Effect of BMPs and Wnt3a co-expression on the osteogenetic capacity of osteoblasts.	BMP4 BMP6 BMP7	1.35e-06	6	143	3	27633082
Pubmed	NDST1-dependent heparan sulfate regulates BMP signaling and internalization in lung development.	NDST2 BMP4 BMP5 BMP7	1.89e-06	22	143	4	19299468
Pubmed	Primordial germ cell proliferation is impaired in Fused Toes mutant embryos.	BMP4 BMP5 BMP6 BMP7	1.89e-06	22	143	4	20969841
Pubmed	A large-scale candidate gene association study of age at menarche and age at natural menopause.	HIVEP1 GALT POLG GDF1 BMP4 BMP5 BMP6 BMP7 IGF2R	2.24e-06	275	143	9	20734064
Pubmed	Survival of Hoxa13 homozygous mutants reveals a novel role in digit patterning and appendicular skeletal development.	BMP4 BMP6 BMP7	2.35e-06	7	143	3	20034107
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	SHANK1 YWHAE SHISA7 CYFIP1 SACS MTOR SRGAP3 IQSEC1 GNAS	2.68e-06	281	143	9	28706196
Pubmed	BCOR modulates transcriptional activity of a subset of glucocorticoid receptor target genes involved in cell growth and mobility.	FBRSL1 NCOR1 NCOR2 KDM2B	2.73e-06	24	143	4	33722704
Pubmed	Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.	BMP4 BMP5 BMP6 BMP7 THBS3 SEMA5B PKD1 FGFR3	2.73e-06	210	143	8	16537572
Pubmed	TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population.	GDF1 BMP4 BMP5 BMP6 BMP7	3.23e-06	55	143	5	15342483
Pubmed	Endocardial to myocardial notch-wnt-bmp axis regulates early heart valve development.	BMP4 BMP5 BMP6 BMP7	3.24e-06	25	143	4	23560082
Pubmed	Direct and indirect roles of CNS dorsal midline cells in choroid plexus epithelia formation.	BMP4 BMP6 BMP7	3.75e-06	8	143	3	15975937
Pubmed	BMPER regulates cardiomyocyte size and vessel density in vivo.	BMP4 BMP5 BMP7	3.75e-06	8	143	3	23200275
Pubmed	IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis.	BMP4 BMP5 BMP6 BMP7	3.82e-06	26	143	4	15071597
Pubmed	Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3.	BMP4 BMP7 FGFR3	5.61e-06	9	143	3	9811582
Pubmed	In situ gene expression analysis during BMP2-induced ectopic bone formation in mice shows simultaneous endochondral and intramembranous ossification.	BMP4 BMP6 BMP7	5.61e-06	9	143	3	12708796
Pubmed	Bone morphogenetic protein 6-induced interleukin-1β expression in macrophages requires PU.1/Smad1 interaction.	BMP4 BMP6 BMP7	8.00e-06	10	143	3	21571370
Pubmed	BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells.	BMP4 BMP6 BMP7	8.00e-06	10	143	3	18436533
Pubmed	Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation.	BMP4 BMP6 BMP7	8.00e-06	10	143	3	16109715
Pubmed	Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas.	BMP4 BMP5 BMP6 BMP7 FGFR3	8.00e-06	66	143	5	12666204
Pubmed	Deletion of Lrp4 increases the incidence of microphthalmia.	BMP4 BMP5 BMP6 BMP7 FGFR3	9.96e-06	69	143	5	30352686
Pubmed	HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity.	RELA NCOR1 NCOR2	1.10e-05	11	143	3	32467224
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SHANK1 EBF3 NPEPPS SIPA1 YWHAE SHISA7 NCOR1 NCOR2 CYFIP1 IGF2R WTIP MTOR SRGAP3 PDE4DIP IQSEC1	1.10e-05	963	143	15	28671696
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DHX36 SZT2 HAUS5 FBRSL1 SPIRE1 HEPH TUBGCP6 NUP155 CELSR3 SEMA5B KDM2B	1.29e-05	529	143	11	14621295
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	HIVEP1 USP43 SPIRE1 PTPN21 YWHAE RADIL PTPN13 MTOR CEP95 IQSEC1 TMEM102 PROSER2 GNAS PLEKHA7	1.36e-05	861	143	14	36931259
Pubmed	A directed protein interaction network for investigating intracellular signal transduction.	A1BG HAUS5 NVL POR RELA CBLB MAP3K12 YWHAE SEMA5B MTOR MCM3AP HPS6 PDE4DIP PHACTR3 DMPK CNTFR	1.67e-05	1124	143	16	21900206
Pubmed	Regulation of mTOR by polycystin-1: is polycystic kidney disease a case of futile repair?	MTOR PKD1	1.68e-05	2	143	2	17102641
Pubmed	Bone morphogenetic protein (BMP)-4 and BMP-7 regulate differentially transforming growth factor (TGF)-beta1 in normal human lung fibroblasts (NHLF).	BMP4 BMP7	1.68e-05	2	143	2	20573231
Pubmed	CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.	NCOR1 NCOR2	1.68e-05	2	143	2	27733359
Pubmed	Bone morphogenetic protein -4 and -5 in pancreatic cancer--novel bidirectional players.	BMP4 BMP5	1.68e-05	2	143	2	21704030
Pubmed	Corepressors (NCoR and SMRT) as well as coactivators are recruited to positively regulated 1α,25-dihydroxyvitamin D3-responsive genes.	NCOR1 NCOR2	1.68e-05	2	143	2	22944139
Pubmed	Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: differential effects of BMP-6 and BMP-7.	BMP6 BMP7	1.68e-05	2	143	2	21898381
Pubmed	Bone morphogenetic protein (BMP)-4 and BMP-7 suppress granulosa cell apoptosis via different pathways: BMP-4 via PI3K/PDK-1/Akt and BMP-7 via PI3K/PDK-1/PKC.	BMP4 BMP7	1.68e-05	2	143	2	22209843
Pubmed	Endogenous bone morphogenetic proteins mediate 1alpha, 25-dihydroxyvitamin D(3)-induced expression of osteoblast differentiation markers in human dermal fibroblasts.	BMP4 BMP6	1.68e-05	2	143	2	18683889
Pubmed	Effects of BMP-7 on mouse tooth mesenchyme and chick mandibular mesenchyme.	BMP4 BMP7	1.68e-05	2	143	2	10633853
Pubmed	Expression of the GTP-binding protein (Galphas) is repressed by the nuclear factor kappaB RelA subunit in human myometrium.	RELA GNAS	1.68e-05	2	143	2	16081638
Pubmed	Aberrant corepressor interactions implicated in PML-RAR(alpha) and PLZF-RAR(alpha) leukemogenesis reflect an altered recruitment and release of specific NCoR and SMRT splice variants.	NCOR1 NCOR2	1.68e-05	2	143	2	21131350
Pubmed	Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-K B/JNK signaling pathway in aging mouse model.	RELA AGER	1.68e-05	2	143	2	25401971
Pubmed	Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways.	NCOR1 NCOR2	1.68e-05	2	143	2	19299558
Pubmed	NF-κB downregulates Cbl-b through binding and suppressing Cbl-b promoter in T cell activation.	RELA CBLB	1.68e-05	2	143	2	25762784
Pubmed	Unique forms of human and mouse nuclear receptor corepressor SMRT.	NCOR1 NCOR2	1.68e-05	2	143	2	10077563
Pubmed	Bone morphogenetic protein-4 and 7 and receptors regulate vascular endothelial growth factor and receptors in human fetal leptomeninges.	BMP4 BMP7	1.68e-05	2	143	2	26304754
Pubmed	The common P450 oxidoreductase variant A503V is not a modifier gene for 21-hydroxylase deficiency.	CYP21A2 POR	1.68e-05	2	143	2	18397975
Pubmed	Nuclear Receptor Corepressors NCOR1 and SMRT Regulate Metabolism via Intestinal Regulation of Carbohydrate Transport.	NCOR1 NCOR2	1.68e-05	2	143	2	39106294
Pubmed	Bone morphogenetic proteins differentially regulate pigmentation in human skin cells.	BMP4 BMP6	1.68e-05	2	143	2	22641693
Pubmed	Evolution of NCoR-1 and NCoR-2 corepressor alternative mRNA splicing in placental mammals.	NCOR1 NCOR2	1.68e-05	2	143	2	31208445
Pubmed	The prodomain of BMP4 is necessary and sufficient to generate stable BMP4/7 heterodimers with enhanced bioactivity in vivo.	BMP4 BMP7	1.68e-05	2	143	2	25902523
Pubmed	NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming.	NCOR1 NCOR2	1.68e-05	2	143	2	29531310
Pubmed	Analysis of BMP4 and BMP7 signaling in breast cancer cells unveils time-dependent transcription patterns and highlights a common synexpression group of genes.	BMP4 BMP7	1.68e-05	2	143	2	22118688
Pubmed	Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse.	BMP4 BMP6	1.68e-05	2	143	2	1893873
Pubmed	Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection.	RELA NOD2	1.68e-05	2	143	2	12527755
Pubmed	Control of mTORC1 signaling by the Opitz syndrome protein MID1.	MTOR MID1	1.68e-05	2	143	2	21555591
Pubmed	Regulation of corepressor alternative mRNA splicing by hormonal and metabolic signaling.	NCOR1 NCOR2	1.68e-05	2	143	2	26166430
Pubmed	Murine osteogenic protein (OP-1): high levels of mRNA in kidney.	BMP6 BMP7	1.68e-05	2	143	2	1715687
Pubmed	BMP4 and BMP7 induce the white-to-brown transition of primary human adipose stem cells.	BMP4 BMP7	1.68e-05	2	143	2	24284793
Pubmed	Interaction between gonadotropin-releasing hormone and bone morphogenetic protein-6 and -7 signaling in LβT2 gonadotrope cells.	BMP6 BMP7	1.68e-05	2	143	2	21846488
Pubmed	Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis.	BMP4 BMP5	1.68e-05	2	143	2	16542506
Pubmed	Characterization of human bone morphogenetic protein (BMP)-4 and -7 gene promoters: activation of BMP promoters by Gli, a sonic hedgehog mediator.	BMP4 BMP7	1.68e-05	2	143	2	11472891
Pubmed	Myocardial β-Catenin-BMP2 signaling promotes mesenchymal cell proliferation during endocardial cushion formation.	BMP4 BMP5 BMP6 BMP7	1.81e-05	38	143	4	30201295
Interaction	GCM1 interactions	HIVEP1 FBRSL1 DNTTIP1 NCOR1 NCOR2 KDM2B RCOR3	4.80e-07	68	141	7	int:GCM1
Interaction	TOP3B interactions	DOCK3 CRYBG2 SZT2 SPEG POLG FBRSL1 SPIRE1 NOD2 NCOR1 BMP4 NCOR2 RADIL HAUS4 CELSR1 IGF2R CELSR3 MTOR MCM3AP HPS6 PKD1 LRP3 SNX15 GNAS RPP25L DDX28 ABCC10 PKN3 ARHGAP33	9.97e-07	1470	141	28	int:TOP3B
GeneFamily	Bone morphogenetic proteins\|Astacins	BMP4 BMP5 BMP6 BMP7	2.94e-07	11	101	4	455
GeneFamily	Adhesion G protein-coupled receptors, subfamily C\|CELSR cadherins	CELSR1 CELSR3	9.24e-05	3	101	2	913
GeneFamily	Adhesion G protein-coupled receptors, subfamily C\|CELSR cadherins	CELSR1 CELSR3	9.24e-05	3	101	2	1189
GeneFamily	HAUS augmin like complex	HAUS5 HAUS4	8.46e-04	8	101	2	581
GeneFamily	Endogenous ligands	NRTN GDF1 BMP4 BMP5 BMP6 BMP7	2.14e-03	237	101	6	542
CoexpressionAtlas	Ectoderm Differentiated Cells_vs_Endoderm Differentiated Cells-Confounder_removed-fold2.0_adjp0.05	DOCK3 COL26A1 RNPC3 NLRP1 GDF1 MAP3K12 HEPH TUBGCP6 BMP4 FREM2 BMP7 THBS3 NRBP2 PTPN13 AGER MID1 IQSEC1 FGFR3 DMPK CNTFR	3.22e-05	1075	142	20	PCBC_ratio_ECTO_vs_DE_cfr-2X-p05
CoexpressionAtlas	Ectoderm Differentiated Cells_vs_Pluripotent Stem Cells-Confounder_removed-fold2.0_adjp0.05	DOCK3 COL26A1 RNPC3 NDST2 NLRP1 PTPN21 GDF1 HEPH ZNF710 TUBGCP6 BMP4 BMP7 THBS3 CELSR1 NRBP2 PTPN13 WTIP AGER PKD1 IQSEC1 KATNIP FGFR3 DMPK CNTFR	3.89e-05	1466	142	24	PCBC_ratio_ECTO_vs_SC_cfr-2X-p05
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_MT1G\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TLCD1 HEPH BMP7 RGS20 RAB34 FGFR3 PLEKHA7	2.49e-06	187	143	7	2b1b2c3792d6c9ab69675ce88842bb589414b530
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEPH FREM2 BMP7 RGS20 RAB34 FGFR3 PLEKHA7	2.76e-06	190	143	7	5c64b727669b23d2a23c8ad1d5d6caab7af37d56
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Lamp5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NRTN LMAN1L BMP4 HAUS4 TMEM132E QPCT	1.51e-05	164	143	6	08819970174a3eb4eee8e1e675075828665b845e
ToppCell	facs-Lung-EPCAM-3m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SZT2 TYSND1 BCDIN3D KCNH1 PROSER2 TRIM47	1.51e-05	164	143	6	1d0d88132baaa3154c3e6e4ef0aff795afab08a2
ToppCell	facs-Lung-EPCAM-3m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SZT2 TYSND1 BCDIN3D KCNH1 PROSER2 TRIM47	1.51e-05	164	143	6	bd2e10b015d5e6a338675500ec5d81dc39583b3e
ToppCell	droplet-Marrow-BM-1m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPIRE1 MAP3K12 PTPN13 RAB34 QPCT TTLL13	1.73e-05	168	143	6	2e88d9cb7c80a4656fab290db8b45a5a0599d769
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCDIN3D BMP4 BMP6 PRDM10 SACS ARHGAP33	1.85e-05	170	143	6	50c6c571591aa4b218caefe5778c570c809f567e
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCDIN3D BMP4 BMP6 PRDM10 SACS ARHGAP33	1.85e-05	170	143	6	8fe32dcf924d5f6665f7febbc9647d96b1e96f06
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCDIN3D BMP4 BMP6 PRDM10 SACS ARHGAP33	1.85e-05	170	143	6	3232db50b1a40f861e981a1b9c9073b81af9f832
ToppCell	droplet-Lung-30m-Hematologic-myeloid-classical_monocyte_proliferating-\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C8orf88 NRTN CELSR1 NRBP2 QPCT MTFR2	1.92e-05	171	143	6	1efce222989460bb59bd9fa955e7d9a60c73994c
ToppCell	droplet-Thymus-nan-3m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TIFAB HEPH CELSR3 TMEM102 DMPK CNTFR	1.92e-05	171	143	6	25493a4a7b636920e2cfd984542cc500709c9dcf
ToppCell	droplet-Thymus-nan-3m-Myeloid-professional_antigen_presenting_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TIFAB HEPH CELSR3 TMEM102 DMPK CNTFR	1.92e-05	171	143	6	508b41e3ad2638f9dd546d251b13ff60fc8c3207
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C8orf88 ADAM8 RAB34 SRGAP3 QPCT PROSER2	1.98e-05	172	143	6	a5344760b10ecdc0101f78b93b8fc0f8107068c5
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NRTN RADIL AGER HPS6 ABCC10 ARHGAP33	2.18e-05	175	143	6	96219e58dcb327fd27190be78193e7a0d611e62b
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NRTN RADIL AGER HPS6 ABCC10 ARHGAP33	2.18e-05	175	143	6	cb974fbebe8cb58c7d3f7defabb4e056f2fee5fa
ToppCell	droplet-Lung-21m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C8orf88 ADAM8 RAB34 SRGAP3 QPCT PROSER2	2.18e-05	175	143	6	4655d3daa95e8ffa7d5ee4180de06b2fec361bfb
ToppCell	droplet-Lung-21m-Hematologic-myeloid-myeloid_dendritic_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C8orf88 TIFAB ADAM8 SRGAP3 QPCT PROSER2	2.26e-05	176	143	6	7d1e2627d7ec5ddd6c87c55d2a6879255b76949e
ToppCell	facs-Lung-EPCAM-18m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TIFAB CORO2A ADAM8 RAB34 QPCT HCLS1	2.33e-05	177	143	6	7bc92314b22a876296a4e2db51e7fb0fdfd69379
ToppCell	mild-Myeloid-pDC\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	TLCD1 COL26A1 TIFAB PTK7 SLC12A3 KLHL33	2.56e-05	180	143	6	38614155fa537d0defda914c531c697be0ef06d8
ToppCell	facs-Skin-Anagen-3m-Epithelial-Basal_IFE\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CBLB ADAM8 NOD2 BMP4 CELSR1 TRIM47	2.72e-05	182	143	6	22d6f4790950508e8aa27e02a8133af5f53f13c8
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRSS36 CELSR1 AGER PROSER2 PLEKHA7 SLC22A31	2.81e-05	183	143	6	ff6dde877659cde9daa3263db0932c9c9ef1adac
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TLCD1 HEPH FREM2 RGS20 RAB34 FGFR3	3.08e-05	186	143	6	73cf266aeecd3cc15e8cb6094588a393bca8fbe6
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEPH BMP7 RGS20 RAB34 FGFR3 PLEKHA7	3.17e-05	187	143	6	dd1d91f101b837bba513f77defa6e6902b2c0570
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEPH BMP7 RGS20 RAB34 FGFR3 PLEKHA7	3.17e-05	187	143	6	4d2115a05ec36dd179ca1d4a525f2d4501aea557
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEPH BMP7 RGS20 RAB34 FGFR3 PLEKHA7	3.17e-05	187	143	6	ae90c263f80c36a410150d499e268d198944a3d9
ToppCell	LPS-IL1RA-Epithelial_alveolar\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRSS36 DNTTIP1 PTPN13 AGER PLEKHA7 SLC22A31	3.27e-05	188	143	6	6164d467b612767ceba15de34176bcc8e8c36ab8
ToppCell	COVID-19-lung-Secretory\|lung / Disease (COVID-19 only), tissue and cell type	CELSR1 PTPN13 SYT8 SRGAP3 FGFR3 PLEKHA7	3.36e-05	189	143	6	84d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Astro\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TLCD1 HEPH RGS20 RAB34 FGFR3 PLEKHA7	3.46e-05	190	143	6	78cc6c28b31de041c24175a98f47da256ecc15a2
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEPH BMP7 RGS20 RAB34 FGFR3 PLEKHA7	3.46e-05	190	143	6	3a55cc5dc2549788bfe55f649686887b21a1fdd2
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Astro-Astrocyte\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TLCD1 HEPH RGS20 RAB34 FGFR3 PLEKHA7	3.46e-05	190	143	6	e67d9400467b438592690b23d681e6c2fb8f09fd
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEPH BMP7 RGS20 RAB34 FGFR3 PLEKHA7	3.46e-05	190	143	6	b56c55f608b30f7379941ac7d5f0f5200f305fca
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro-Astrocyte\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEPH BMP7 RGS20 RAB34 FGFR3 PLEKHA7	3.46e-05	190	143	6	1c3d601422efa60fad8565f9ccd9032b847e4a91
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TLCD1 SPIRE1 CELSR1 RGS20 FGFR3 CNTFR	3.57e-05	191	143	6	fd345837bfc40d85256b9a7e4fd3343bcbfe0ae5
ToppCell	facs-Heart-LA-3m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HID1 BMP6 CELSR1 FRRS1 IGF2R PKN3	3.67e-05	192	143	6	14a816ef116aa992f86edab411f043cf7d07fe04
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro-Astrocyte\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEPH BMP7 RGS20 RAB34 FGFR3 PLEKHA7	3.67e-05	192	143	6	f7e4509003d71f805b9d4587098e90d2897b6739
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEPH BMP7 RGS20 RAB34 FGFR3 PLEKHA7	3.67e-05	192	143	6	43beaac1de99b9c1a6dab4a450b4e81286987b64
ToppCell	COVID-19-lung-Secretory\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CORO2A CELSR1 PTPN13 SYT8 SRGAP3 FGFR3	3.67e-05	192	143	6	59261098ccb52306f837f632ebaea45b90ad30fe
ToppCell	IPF-Epithelial-Basal\|World / Disease state, Lineage and Cell class	CELSR1 PTPN13 SYT8 SRGAP3 MID1 FGFR3	3.67e-05	192	143	6	9b91e0b162e6f3ce86dd15cc33c2e745d069581f
ToppCell	facs-Heart-LA-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HID1 BMP6 CELSR1 FRRS1 IGF2R PKN3	3.67e-05	192	143	6	847822514d747a21d5eb40e04ba9a023fd32bd65
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEPH BMP7 RGS20 RAB34 FGFR3 PLEKHA7	3.67e-05	192	143	6	705ce805cb00a53793b57bcf466d0fbec590a83c
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEPH BMP7 RGS20 RAB34 FGFR3 PLEKHA7	3.78e-05	193	143	6	b03d908d4b8940927f72c76a1b0f237d13f39056
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEPH BMP7 RGS20 RAB34 FGFR3 PLEKHA7	3.78e-05	193	143	6	40edc07b6e7f19f6ee885fa5af0b63ef1b0f2468
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-NK-NK-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	HIVEP1 POLG NVL TUBGCP6 AGER PRR34	3.89e-05	194	143	6	3211d89440a6f4a9b3d4cfb755890816944242ec
ToppCell	Biopsy_Control_(H.)-Immune-pDCs\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	C8orf88 COL26A1 TIFAB CDHR5 SLC12A3 KLHL33	4.01e-05	195	143	6	47d139215f0b51f5ea9b5fb09b1100e320e3f1e2
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-tRG\|World / Primary Cells by Cluster	BMP7 CELSR1 SEMA5B MID1 FGFR3 PLEKHA7	4.24e-05	197	143	6	61749ccafeb938c310cff1de5ff924a1c794325a
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	CACNA1F CELSR1 PTPN13 AGER PLEKHA7 SLC22A31	4.24e-05	197	143	6	3d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-tRG-25\|World / Primary Cells by Cluster	BMP7 CELSR1 SEMA5B MID1 FGFR3 PLEKHA7	4.24e-05	197	143	6	9d4ffa3680f92c91d0a081f9a8ec5ebfec6bdcf6
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	BMP6 CELSR1 PTPN13 SRGAP3 FGFR3 PLEKHA7	4.36e-05	198	143	6	af399569c718f5fd971d73a7926768c9311002a3
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Club\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	BMP6 CELSR1 PTPN13 SRGAP3 FGFR3 PLEKHA7	4.36e-05	198	143	6	1408e02e053ad3406229bfe8189da03be6366e81
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	PTK7 BMP4 BMP5 RAB34 PHACTR3 CNTFR	4.48e-05	199	143	6	c2c42ecf20d1924edc2f899c01dfa5fcf3c210b9
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Cervical_Squamous_Cell_Carcinoma\|TCGA-Cervix / Sample_Type by Project: Shred V9	DHRS13 TYSND1 AGER DMPK CNTFR	6.52e-05	131	143	5	88b3298110bc2333ffa202a3f41ac0d24e2308c7
ToppCell	facs-Heart-RV-24m-Myeloid-macrophage\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CORO2A CDHR5 HAUS4 FRRS1 HPS6	7.52e-05	135	143	5	99e7ac9b1139fe4ff036f6f048a8f1cc514c1fb9
ToppCell	facs-Heart-RV-24m-Myeloid-macrophage\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CORO2A CDHR5 HAUS4 FRRS1 HPS6	7.52e-05	135	143	5	1fe684ed5913ae757ad6befbbe12d1bee481dd12
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Dendritic-conventional_dendritic_cell-DC_c3-LAMP3\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GALNT15 DOCK3 BMP6 NRBP2 ABCC10	8.64e-05	139	143	5	bb2b020dda32ddc60ec9952de5b01acee60b5b59
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GALNT15 EBF3 BMP5 SYT8 PKN3	8.64e-05	139	143	5	b07929348ec9ad95d7bce33a7deac0938227b19f
ToppCell	ASK454-Immune-Macrophages\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	PRSS36 NOD2 SPTBN5 HAUS4	9.98e-05	75	143	4	572cea9d3f9afa218037550dacc3524534c673ce
ToppCell	LPS-IL1RA-Endothelial-Mes-Like-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SPEG HAUS5 BMP6 SACS KCNH1	1.05e-04	145	143	5	90ca38c02325c5c637c32efdef634b54cc3cd105
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	NDST2 NOD2 SCNN1D TIGD5 ARHGAP33	1.16e-04	148	143	5	1186ee0d15244fee74c1d09df3967c1b69f8ddce
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Ntn1_Npy2r\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NRTN LMAN1L FREM2 TMEM132E QPCT	1.16e-04	148	143	5	5e738522d4ad35e08bc4ff8c41b7bea38ec6ef95
ToppCell	PND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DOCK3 CORO2A KCNIP2 SRGAP3 HCLS1	1.16e-04	148	143	5	438fe292d29be0206e1d9fd59ede5f8368f13665
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_3\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TIFAB SLC12A3 SRGAP3 ASCL4 SLC22A31	1.27e-04	151	143	5	0b6b37734430918378ed94e40877f0c4ae9b25ec
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_3\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TIFAB SLC12A3 SRGAP3 ASCL4 SLC22A31	1.27e-04	151	143	5	30225a1a7800b0ae19e16ac164f561379eedb99d
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PTK7 ZNF469 SRGAP3 BEST4 ASCL4	1.36e-04	153	143	5	91e9d70a5d3f6fd68c284ed0cc113f03d7d1e10b
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PTK7 ZNF469 SRGAP3 BEST4 ASCL4	1.36e-04	153	143	5	f17f62646633cf95c810dcd5328978058741b276
ToppCell	PND07-Immune-Immune_Myeloid-DC-cDC2-cDC2_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CORO2A GLYCTK SRGAP3 QPCT HCLS1	1.40e-04	154	143	5	e3a8a1e63ab345de62bd2e5e54342b00f04ae422
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	TIFAB NDST2 SPIRE1 NRBP2 CYFIP1	1.48e-04	156	143	5	5b2781d38a83b4b0f8a53cf321ce5db3a07d0818
ToppCell	368C-Myeloid-Monocyte-CD16+_Monocyte\|368C / Donor, Lineage, Cell class and subclass (all cells)	SIPA1 NOD2 PRDM10 SRGAP3 MCM3AP	1.48e-04	156	143	5	25b0936960be4955b6a6d6b8a867fdd4be548f05
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	TIFAB NDST2 SPIRE1 NRBP2 CYFIP1	1.48e-04	156	143	5	e0aef6104be16b12304b8e30358f444c1660e92f
ToppCell	PND03-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CORO2A FBRSL1 RAB34 SRGAP3 QPCT	1.48e-04	156	143	5	af47a4b17342bdb3cb62d7e2d52a81168e588629
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like-AT1_Progenitor\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK3 BMP6 AGER PHACTR3 ABCC10	1.53e-04	157	143	5	a93866f051472506f1468f379c0d5313e02c9731
ToppCell	PND03-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NLRP1 FRRS1 SNX15 MTFR2 HCLS1	1.53e-04	157	143	5	eea53cf8d8a607264e1ee00b7a97c94bcf2ac80d
ToppCell	Basal_cells-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	CRYBG2 KCNIP2 SYT8 SRGAP3 TRIM47	1.58e-04	158	143	5	dd069a822e9698e6dddc155d9a5b52383f7879d5
ToppCell	PND07-Immune-Immune_Myeloid-DC-cDC1-cDC1_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CORO2A ADAM8 SHISA7 RAB34 HCLS1	1.62e-04	159	143	5	a5fee9e7ee00c20a4ba30b0dfaf1189fb109a1af
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	NCOR1 THBS3 PRDM10 NRBP2 ABCE1	1.67e-04	160	143	5	8bb873704895c3b35bba8af78fedbabf7df42e71
ToppCell	facs-Heart-RA-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRTN SLC12A3 PDE4DIP DMPK SBK2	1.77e-04	162	143	5	3a61eda548afa2a41bdf6293d1050103dc210e52
ToppCell	facs-Heart-RA-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRTN SLC12A3 PDE4DIP DMPK SBK2	1.77e-04	162	143	5	593939be9d38690c89c31d4c58e351de26cbf9ab
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TIFAB NLRP1 RAB34 HPS6 KDM2B	1.87e-04	164	143	5	54f8f11d2fa899005530c08e7a1ee728c7b0799c
ToppCell	PND07-Immune-Immune_Myeloid-DC-cDC1\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CORO2A ADAM8 RAB34 SRGAP3 HCLS1	1.87e-04	164	143	5	662f74ad2656c0af158dbf9eb81d5bf70f54e529
ToppCell	droplet-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TIFAB CORO2A SPIRE1 LMAN1L RAB34	1.93e-04	165	143	5	1c630f9ecde2e0243922a2be4b1ab5adcfcb0893
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GPR150 PHACTR3 QPCT ASCL4 TRIM47	2.04e-04	167	143	5	49d9220f22d10ff06c0512c9c40c26ad51728e4f
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HID1 NRBP2 WTIP PHACTR3 DMPK	2.04e-04	167	143	5	d1a13d6ada572d8ddb2da95e6e122d2b705fad7f
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GPR150 PHACTR3 QPCT ASCL4 TRIM47	2.04e-04	167	143	5	7ec032a98a13504d15c7e3a4e259278d07f40180
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GPR150 PHACTR3 QPCT ASCL4 TRIM47	2.04e-04	167	143	5	5e3588eee73693a996bb4846427cf0038ceafbca
ToppCell	droplet-Lung-3m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l4\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1F CRYBG2 BMP7 HPS6 HCLS1	2.10e-04	168	143	5	19d2c763b50e7168dfa7449fc407489b055526c2
ToppCell	droplet-Lung-3m-Hematologic-lymphocytic-mature_NK_T_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1F CRYBG2 BMP7 HPS6 HCLS1	2.10e-04	168	143	5	fa198bd53b2d640d9a8684783bf5ca23314caae2
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-4\|TCGA-Liver / Sample_Type by Project: Shred V9	TYSND1 PTK7 FGFR3 GNAS ABCC10	2.15e-04	169	143	5	0a3ba6b5d6cff9d3d7f56046063cfc3a37ae1156
ToppCell	facs-GAT-Fat-18m-Myeloid-nan\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TIFAB CORO2A ADAM8 ZNF710 HCLS1	2.15e-04	169	143	5	7a7416fcbffcf57d19b477d9da091e04e3499524
ToppCell	facs-GAT-Fat-18m-Myeloid\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TIFAB CORO2A ADAM8 ZNF710 HCLS1	2.15e-04	169	143	5	0e1a99cd77edcf32bcb513abd247b2b27409ac63
ToppCell	facs-GAT-Fat-18m-Myeloid-myeloid_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TIFAB CORO2A ADAM8 ZNF710 HCLS1	2.15e-04	169	143	5	9bbad31ef03078f5aa456f2e1b17b49c91545ff0
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn_(Dcn)\|Thalamus / BrainAtlas - Mouse McCarroll V32	NLRP1 ADAM8 MID1 TMEM102	2.20e-04	92	143	4	bbaf5a131f860198840e34843b7c841bcc98d9c4
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn_(Dcn)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	NLRP1 ADAM8 MID1 TMEM102	2.20e-04	92	143	4	e6aa2b8ca9235a7291ee41d976b886fec185835d
ToppCell	E16.5-samps-Epithelial-Alveolar_epithelial_precursor-Uncommitted_AE_cell\|E16.5-samps / Age Group, Lineage, Cell class and subclass	FREM2 THBS3 CELSR1 AGER PLEKHA7	2.21e-04	170	143	5	5a64e05c263df915085988d881808221e2c0f2e2
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL26A1 TIFAB CDHR5 SLC12A3 KLHL33	2.21e-04	170	143	5	92e765ae0d3adb38d3b22fddb873fd5ccad3fd44
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL26A1 TIFAB CDHR5 SLC12A3 KLHL33	2.21e-04	170	143	5	9f8b215caa1afa3cd7104c06fca7cfd790640f66
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Enterocyte_(Proximal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRYBG2 CORO2A POR CDHR5 HEPH	2.27e-04	171	143	5	5d0d6c1ff610a703ae0b834a12823c5ff9012932
ToppCell	COVID-pDC\|COVID / Condition, Cell_class and T cell subcluster	COL26A1 TIFAB CDHR5 SLC12A3 KLHL33	2.34e-04	172	143	5	3ecbb000495dde32f6153ef6bdea9c8802ff3985
ToppCell	mild_COVID-19-pDC\|World / disease group, cell group and cell class (v2)	COL26A1 TIFAB PTK7 SLC12A3 KLHL33	2.34e-04	172	143	5	dab2f1a05c7df58d9387b13271b3f1f1583f9ac3
ToppCell	COVID-pDC-\|COVID / Condition, Cell_class and T cell subcluster	COL26A1 TIFAB CDHR5 SLC12A3 KLHL33	2.34e-04	172	143	5	a7827faa1afab51fdaf0cb1a2babcd2e00d411e5
ToppCell	droplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C8orf88 SHISA7 SRGAP3 QPCT PROSER2	2.40e-04	173	143	5	70c0c13febd28b395fb3171ec8d7fbbc6c9d4eb7
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FBRSL1 BMP6 HAUS4 IGF2R TRIM47	2.40e-04	173	143	5	4968712af1cca8c932abd3323631d7dcaffd4a66
Disease	Marfan syndrome (implicated_via_orthology)	BMP4 BMP6 BMP7	1.15e-05	10	137	3	DOID:14323 (implicated_via_orthology)
Disease	renal cell carcinoma (is_marker_for)	RELA BMP4 BMP6 BMP7 MTOR KCNH1	3.06e-05	128	137	6	DOID:4450 (is_marker_for)
Disease	ciliary neurotrophic factor receptor subunit alpha measurement	RPP25L CNTFR	6.40e-05	3	137	2	EFO_0020261
Disease	Endocrine System Diseases	MTOR GNAS	6.40e-05	3	137	2	C0014130
Disease	autosomal dominant polycystic kidney disease (is_implicated_in)	MTOR PKD1	1.28e-04	4	137	2	DOID:898 (is_implicated_in)
Disease	scoliosis (implicated_via_orthology)	PTK7 FGFR3	2.12e-04	5	137	2	DOID:0060249 (implicated_via_orthology)
Disease	diabetes mellitus (implicated_via_orthology)	BMP5 BMP6 BMP7	2.35e-04	26	137	3	DOID:9351 (implicated_via_orthology)
Disease	stimulant use measurement	HIVEP1 CYP21A2 DLEC1	2.95e-04	28	137	3	EFO_0600076
Disease	congenital adrenal hyperplasia (is_implicated_in)	CYP21A2 POR	3.17e-04	6	137	2	DOID:0050811 (is_implicated_in)
Disease	neuroimaging measurement	COL26A1 SZT2 CYP21A2 PTPN21 YWHAE PTK7 NCOR1 BMP6 ZNF469 CELSR1 PKD1 FGFR3 TRIM47 PLEKHA7	4.67e-04	1069	137	14	EFO_0004346
Disease	citrate measurement	CYP21A2 POR IGF2R PHACTR3	5.10e-04	79	137	4	EFO_0010114
Disease	Unilateral agenesis of kidney	BMP4 FREM2	5.88e-04	8	137	2	C0266294
Disease	glycosyl-N-(2-hydroxynervonoyl)-sphingosine (d18:1/24:1(2OH)) measurement	CYP21A2 PRDM10	5.88e-04	8	137	2	EFO_0800533
Disease	cortical thickness	COL26A1 LMAN1L BMP4 BMP6 BMP7 ZNF469 THBS3 CELSR1 SRGAP3 PKD1 DLEC1 FGFR3 PLEKHA7 ABCC10	6.93e-04	1113	137	14	EFO_0004840
Disease	Congenital adrenal hyperplasia	CYP21A2 POR	7.54e-04	9	137	2	C0001627
Disease	1-ribosyl-imidazoleacetate measurement	CYP21A2 TIGD5	7.54e-04	9	137	2	EFO_0800034
Disease	creatinine measurement	SPEG CYP21A2 POR CBLB BMP4 THBS3 IGF2R CELSR3 RCOR3 DLEC1 GNAS PLEKHA7 ABCC10	7.65e-04	995	137	13	EFO_0004518
Disease	Cleft upper lip	BMP4 FGFR3 PLEKHA7	7.92e-04	39	137	3	C0008924
Disease	Schizophrenia	SHANK1 A1BG CACNA1F RELA PTPN21 YWHAE CYFIP1 MTOR SRGAP3 AGER KDM2B GNAS	8.73e-04	883	137	12	C0036341
Disease	Congenital small ears	BMP5 FREM2 FGFR3	9.17e-04	41	137	3	C0152423
Disease	colitis (biomarker_via_orthology)	RELA NOD2 BMP6	9.85e-04	42	137	3	DOID:0060180 (biomarker_via_orthology)
Disease	Intellectual Disability	GALT BCKDK SACS ZDHHC9 MTOR SRGAP3 IQSEC1 GNAS	1.19e-03	447	137	8	C3714756
Disease	urinary albumin to creatinine ratio	CYP21A2 POR THBS3 RGS20 ARHGAP33	1.52e-03	179	137	5	EFO_0007778
Disease	juvenile polyposis syndrome (implicated_via_orthology)	HIVEP1 BMP4	1.61e-03	13	137	2	DOID:0050787 (implicated_via_orthology)
Disease	Cakut	BMP4 BMP7	1.61e-03	13	137	2	C1968949
Disease	Connective Tissue Diseases	ZNF469 PKD1	1.61e-03	13	137	2	C0009782
Disease	Epilepsy	POLG ZDHHC9 KCNH1 FGFR3	1.70e-03	109	137	4	C0014544
Disease	breast cancer (is_marker_for)	BMP4 NCOR2 BMP6 BMP7 FGFR3	1.76e-03	185	137	5	DOID:1612 (is_marker_for)
Disease	Arthritis, Psoriatic	NOD2 BMP4	1.88e-03	14	137	2	C0003872
Disease	Neoplasm of uncertain or unknown behavior of bladder	MTOR FGFR3	2.16e-03	15	137	2	C0496930
Disease	Benign neoplasm of bladder	MTOR FGFR3	2.16e-03	15	137	2	C0154017
Disease	Carcinoma in situ of bladder	MTOR FGFR3	2.16e-03	15	137	2	C0154091
Disease	vascular endothelial growth factor measurement	ZNF710 PTK7 SEMA5B	2.27e-03	56	137	3	EFO_0004762
Disease	polyp of colon	BMP4 BMP5 TTLL13	2.27e-03	56	137	3	MONDO_0021400
Disease	Alzheimer's disease (implicated_via_orthology)	HIVEP1 AGER RCOR3	2.39e-03	57	137	3	DOID:10652 (implicated_via_orthology)
Disease	Diabetic Angiopathies	RELA AGER	2.46e-03	16	137	2	C0011875
Disease	Microangiopathy, Diabetic	RELA AGER	2.46e-03	16	137	2	C0025945
Disease	gliosarcoma	POR FGFR3	2.46e-03	16	137	2	C0206726
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	MTOR PKD1	2.46e-03	16	137	2	DOID:0110861 (implicated_via_orthology)
Disease	testosterone measurement	GALNT15 DOCK3 NPEPPS GLYCTK USP43 POR PTPN21 NCOR2 BMP5 BMP6 TMEM102 ABCC10 PKN3 CNTFR	2.48e-03	1275	137	14	EFO_0004908
Disease	calcium measurement	CYP21A2 HEPH THBS3 SEMA5B QPCT GNAS HCLS1 ABCC10 PKN3	2.72e-03	628	137	9	EFO_0004838
Disease	systolic blood pressure, alcohol drinking	SIPA1 LMAN1L PLEKHA7 ABCC10	3.04e-03	128	137	4	EFO_0004329, EFO_0006335
Disease	Carcinoma of bladder	MTOR FGFR3	3.12e-03	18	137	2	C0699885
Disease	polycystic kidney disease (biomarker_via_orthology)	MTOR GNAS	3.47e-03	19	137	2	DOID:0080322 (biomarker_via_orthology)
Disease	maximal midexpiratory flow rate	GALNT15 TUBGCP6	3.85e-03	20	137	2	EFO_0004313
Disease	ulcerative colitis, Crohn's disease	NOD2 NCOR2	3.85e-03	20	137	2	EFO_0000384, EFO_0000729
Disease	C-reactive protein measurement	DOCK3 NDST2 HID1 BCDIN3D PTK7 NCOR1 RADIL ZNF469 NRBP2 PKD1 KDM2B ASCL4 ARHGAP33	4.13e-03	1206	137	13	EFO_0004458
Disease	Bladder Neoplasm	POR NCOR1 MTOR FGFR3	4.19e-03	140	137	4	C0005695
Disease	epilepsy (biomarker_via_orthology)	RELA BMP4	4.24e-03	21	137	2	DOID:1826 (biomarker_via_orthology)
Disease	osteoarthritis, hip, osteoarthritis, knee, total joint arthroplasty	NCOR2 FGFR3	4.24e-03	21	137	2	EFO_0004616, EFO_0010726, EFO_1000786
Disease	status epilepticus (implicated_via_orthology)	RELA MTOR	4.24e-03	21	137	2	DOID:1824 (implicated_via_orthology)
Disease	Malignant neoplasm of urinary bladder	POR NCOR1 MTOR FGFR3	4.30e-03	141	137	4	C0005684

Protein segments in the cluster

Peptide	Gene	Start	Entry
RLGPRLRAAPLLAPL	nan	81	Q9H8V8
TPRPPHLLRFRAEEG	BEST4	436	Q8NFU0
TELPPTHPIRLGLAL	YWHAE	161	P62258
LRGELERARAPHLPP	FBRSL1	941	Q9HCM7
LLDRISHTRPGFLPP	ANKRD34C	451	P0C6C1
RAQLPTHRPGLPRLS	CXorf49;	406	A8MYA2
HPPEQRLRLLPPELL	BCDIN3D	41	Q7Z5W3
DPDRRSLRLPHRPII	CELSR1	2356	Q9NYQ6
RLPGPRVRRALPSHL	ADAM8	36	P78325
AVPTGHILPSPLVLR	CDHR5	256	Q9HBB8
PLRPLLGPALALRAR	BCKDK	16	O14874
PPAEVVPGHLITRLL	BMP4	186	P12644
REILSILGLPHRPRP	BMP7	56	P18075
PLLRPTLPAAPALHR	RCOR3	416	Q9P2K3
SPGLPRHRALRTAPI	AGER	211	Q15109
LRRGVPVLHLIPSPF	QPCT	311	Q16769
GSRHPTLVLPLVPEL	INTS4	511	Q96HW7
RPDIIDPAILRPGRL	NVL	726	O15381
PPQRLRVTRHPLIPA	KASH5	511	Q8N6L0
RVTRHPLIPAPVLGL	KASH5	516	Q8N6L0
HRLGPALVPLHRLPR	NRTN	31	Q99748
PDILPLHCTIRRQPL	RADIL	291	Q96JH8
RLELHVDGPPPRPQL	A1BG	391	P04217
LIGKPLQPARPVRHL	C8orf88	6	P0DMB2
LRPLRLVSGVPSLHI	CACNA1F	211	O60840
PLHLVPLIERLGTPQ	CYFIP1	1056	Q7L576
RLIRAGPPSEILPLV	ABCC10	801	Q5T3U5
LGLHDTARPVLPRPP	NCOR2	1086	Q9Y618
EELRHTPELPLAPRP	NCOR2	1431	Q9Y618
RAAGLLPPLTPDLLH	KLHL33	176	A6NCF5
LHAVLAELPRPRRPP	NRBP2	341	Q9NSY0
LPVGRRHPPVLRMVL	H1-8	46	Q8IZA3
SLRPPIDHLCELLPR	POR	436	P16435
IRTEAGPRLHIEPPV	KATNIP	141	O60303
PHTPRALGILRRQPL	LMAN1L	506	Q9HAT1
RLRVEHLPLLTIEPP	IQSEC1	371	Q6DN90
ELRPRPPRPLDSHLA	IQSEC1	436	Q6DN90
IRIHPVDRLPPELGS	FREM2	691	Q5SZK8
PLPHELRPLPVLSRT	MCM3AP	686	O60318
HPLARPRRDAEPVLG	GDF1	246	P27539
HLSLPPVPPRLDLIQ	CBLB	501	Q13191
RIPLQRALPEVRHPL	GALNT15	166	Q8N3T1
EVLRLRPVVPLALPH	CYP21A2	351	P08686
LLLLQRPHPRSQDPL	NLRP1	281	Q9C000
PASLRPHRPRLLDPD	KCNIP2	61	Q9NS61
LVRPGPLLVSARRPE	DDX28	61	Q9NUL7
LPRSALPRAVIRHPD	POLG	816	P54098
EAPLILPPDHPVRRL	KCNH1	726	O95259
LFHRPRAPRGQIPLL	LRP3	611	O75074
PPIAHLLRPVLPRAF	TUBGCP6	1441	Q96RT7
PLHPIPNRPVLTRAR	PRDM10	191	Q9NQV6
TLLRHRPGELKPLPT	HAUS5	461	O94927
RLAPALPARPHRGLS	NSUN5P1	116	Q3KNT7
RRHLLLPARVPRPGL	DMPK	571	Q09013
RPNTLTLVHVRLPPG	NUP155	381	O75694
CPRVLLAGPLHILEP	PTPN21	746	Q16825
ISIRLPQHLGLRPPL	PRSS36	666	Q5K4E3
LSPGRSLRPHLIPLL	ARHGAP33	826	O14559
AFKLHRLPIPRPGEV	ABCE1	91	P61221
RELRHQLGPSLRSPP	KDM2B	1006	Q8NHM5
ETERPRGLHRKAPLP	DOCK3	1996	Q8IZD9
QVLPRLARAPLHPLL	GLYCTK	6	Q8IVS8
PLLAVFRPPLHDPRR	FRRS1	461	Q6ZNA5
LPRRHVRRLPELTPA	GALT	256	P07902
LTPLGVHLARLPVEP	DHX36	686	Q9H2U1
VLLHVGLPPREPVLS	CNTFR	101	P26992
SELLRPHPLPAERPI	CORO2A	401	Q92828
PPEILRTHRLPRAPR	CRYBG2	776	Q8N1P7
KEILSVLGLPHRPRP	BMP6	81	P22004
RKLGEPIRAAIPLHP	CEP95	251	Q96GE4
IQREILSILGLPHRP	BMP5	51	P22003
LPIPHQELLRERGPP	MAP3K12	816	Q12852
TLPGLPRRDPLRVAL	ASCL4	26	Q6XD76
LERSPHRPILQAGLP	FGFR3	246	P22607
RLLGPSQEREIPPLL	HAUS4	126	Q9H6D7
HPSREALGPLPQLLR	CELSR3	3211	Q9NYQ7
RHPGDPERLPKEVLL	EBF3	366	Q9H4W6
RHLLLLRPPGAVAPQ	HPS6	41	Q86YV9
AHTLLIPLQARRPPP	DLEC1	461	Q9Y238
SPLLRGRPRQDHLPL	SLC22A31	526	A6NKX4
NPRRPSPVLRHLELL	SCNN1D	301	P51172
HTRPRGTLLRLAGPP	SBK2	206	P0C263
PLVLPSRLIHPEGRV	SACS	2106	Q9NZJ4
LLPGIRDLSLPPVDR	NPEPPS	601	P55786
LPDAIPLAHPVPRQR	COL26A1	181	Q96A83
VGAEHLRPLRLPPTN	IKZF4	376	Q9H2S9
LRHVPGWLRPLLRPL	DHRS13	236	Q6UX07
LPGVDVSRPRLVLPR	PKD1	2206	P98161
GRVLELPRIPMLPHL	PTPN13	1866	Q12923
LRELHARILLPGPGP	PKN3	71	Q6P5Z2
IDTPRPLVGRLIHQL	MTOR	1946	P42345
RPLPPSRVIEELHRA	PHACTR3	286	Q96KR7
LGPAPARRPQRSLLL	IGF2R	11	P11717
LALQPRLRLRLPLPH	SYT8	386	Q8NBV8
LGPSPRPAAERHLLL	SZT2	2596	Q5T011
RSPALRGHRLVPPLR	TRIM47	161	Q96LD4
VEPGRPPLSRRLLAL	RNF187	61	Q5TA31
HPLLRIGSISLFRPP	TMEM132E	266	Q6IEE7
PVRTSREHPVPLLPI	HCLS1	316	P14317
REHPVPLLPIRQTLP	HCLS1	321	P14317
PVEHPRLLRSVPTPL	PROSER2	181	Q86WR7
PLLPALPAARLSRGH	RGS20	106	O76081
GARRKIHLRPPSPEI	GNAS	521	Q5JWF2
VRLPHGRPLPARALA	GPR150	151	Q8NGU9
TLVGLLPVPHPILIR	HID1	731	Q8IV36
IPRPRTGPEEHLGIL	HEPH	796	Q9BQS7
VLPLVHPLPEGLRAS	NCOR1	126	O75376
GPVLRAPRLPHPAAR	PRR34	76	Q9NV39
PAVPPLPREATIIRH	PLEKHA7	936	Q6IQ23
ARHPGIPPTLRDGRL	SHPRH	1081	Q149N8
PPRGLSPRKLLEHVA	SIPA1	286	Q96FS4
KRRPLELPRGTLPLH	SHISA7	336	A6NL88
ELPRGTLPLHALRRP	SHISA7	341	A6NL88
ALPPPSRGRLRVHFL	SPTBN5	101	Q9NRC6
RRSLLHRLPPTAPGV	SHANK1	1441	Q9Y566
FEGLPTRIHLPAPRV	TP53TG5	211	Q9Y2B4
RVLHLRRPGGPPHVK	USP43	486	Q70EL4
LPPSVLDRRGILPLE	ZDHHC9	291	Q9Y397
SPPRGDRTLLVRHLP	RNPC3	21	Q96LT9
GPSLLRGRLPTLLHL	NOD2	536	Q9HC29
CHLVLRPIPELLRAP	SPEG	1886	Q15772
PHKIPLTRGRIESPE	SRGAP3	896	O43295
IPRLTHELPGIKRGR	DNTTIP1	136	Q9H147
RGLLEAPRILPRLNP	THEM5	16	Q8N1Q8
PTPPRPRSLHERILE	SPIRE1	361	Q08AE8
RHEPPRLAPLLIFNP	nan	36	Q6ZSR6
VIPERVLGTPRHIFP	nan	76	Q6ZSR6
KEIPIEPAPHLRRVG	MID1	591	O15344
PLEVSRDLHILPPPL	SNX15	131	Q9NRS6
LIPVPGAPRLVHAAR	TMEM102	281	Q8N9M5
LRHLPRTPRPELNVA	ZNF710	171	Q8N1W2
PDTGLDPLTVRRHVP	RPP25L	101	Q8N5L8
PPRLQHDTSPLLLGR	TIFAB	26	Q6ZNK6
APLLHLTRPSRLEPG	NDST2	206	P52849
PGEPRKVRPTLADLH	SLC12A3	76	P55017
GPLAHRDVPRPILLG	VWA5A	601	O00534
ELHVLPPGRREPLRS	SEMA5B	516	Q9P283
PPGRREPLRSLRILH	SEMA5B	521	Q9P283
LLRLRGPSRPSPALH	THBS3	126	P49746
EIFHPLRLVRDPLSP	MTFR2	106	Q6P444
LCRLPLPVHVRADPL	TLCD1	26	Q96CP7
RPLLRPPKRGTAVHG	ZNF469	3871	Q96JG9
LPPVPLHLRNAPTRL	WRNIP1	611	Q96S55
HLRRLQPGPLPSPTV	WTIP	411	A6NIX2
PLVIGRLPDPPSLRH	TIGD5	291	Q53EQ6
RPLRLPPVLSHPIFD	RELA	171	Q04206
RHKPRETPGRLEIPT	ZNF425	171	Q6IV72
GSPARPRRLPLLSVL	PTK7	6	Q13308
TGHVPLLERRRGPLV	HIVEP1	1416	P15822
SRGRPLQPRLPAELL	TYSND1	121	Q2T9J0
PVLPHESIPRILGAL	TTLL13	666	A6NNM8
AQRLPPPRHLRLPGA	RAB34	176	P0DI83
PHSPPRGTIELGRIL	PDE4DIP	1786	Q5VU43