Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	rRNA (cytosine-N4-)-methyltransferase activity	METTL15 METTL15P1	8.58e-07	2	19	2	GO:0071424
GeneOntologyMolecularFunction	rRNA (cytosine) methyltransferase activity	METTL15 METTL15P1	1.28e-05	6	19	2	GO:0016434
GeneOntologyMolecularFunction	rRNA methyltransferase activity	METTL15 METTL15P1	2.34e-04	24	19	2	GO:0008649
GeneOntologyMolecularFunction	catalytic activity, acting on a rRNA	METTL15 METTL15P1	2.54e-04	25	19	2	GO:0140102
GeneOntologyMolecularFunction	RNA methyltransferase activity	METTL15 METTL15P1	1.83e-03	67	19	2	GO:0008173
GeneOntologyMolecularFunction	N-methyltransferase activity	METTL15 METTL15P1	4.42e-03	105	19	2	GO:0008170
GeneOntologyBiologicalProcess	rRNA base methylation	METTL15 METTL15P1	4.40e-05	11	19	2	GO:0070475
Pubmed	Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice.	METTL15 METTL15P1	2.83e-07	2	19	2	35682734
Pubmed	METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue.	METTL15 METTL15P1	2.83e-07	2	19	2	32573735
Pubmed	Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development.	METTL15 METTL15P1	1.55e-05	11	19	2	33627187
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	LANCL1 CHD6 ZNF142 TAF2 IPO7	1.92e-05	638	19	5	31182584
Pubmed	Analysis of Pax6 contiguous gene deletions in the mouse, Mus musculus, identifies regions distinct from Pax6 responsible for extreme small-eye and belly-spotting phenotypes.	METTL15 METTL15P1	4.81e-05	19	19	2	19474196
Pubmed	Isolation of differentially expressed genes from wild-type and Twist mutant mouse limb buds.	TAF2 IPO7	5.90e-05	21	19	2	12124942
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	ALMS1 CHD6 TAF2 IPO7	1.08e-04	469	19	4	27634302
Pubmed	A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.	ALMS1 ZNF142 KISS1R	1.24e-04	180	19	3	24104479
Pubmed	Aire's partners in the molecular control of immunological tolerance.	CHD6 IPO7	2.76e-04	45	19	2	20085707
Pubmed	Quantitative Proteomics of the SMAD (Suppressor of Mothers against Decapentaplegic) Transcription Factor Family Identifies Importin 5 as a Bone Morphogenic Protein Receptor SMAD-specific Importin.	TAF2 IPO7	3.14e-04	48	19	2	27703004
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	CHD6 TAF2 IPO7	4.64e-04	282	19	3	23667531
Disease	colorectal cancer, inflammatory bowel disease	ALMS1 ATP8B4	5.97e-05	19	18	2	EFO_0003767, MONDO_0005575
Disease	diastolic blood pressure, systolic blood pressure	ALMS1 CHD6 ATP8B4 TAF2	6.26e-04	670	18	4	EFO_0006335, EFO_0006336
Disease	age at menopause	CHD6 PGAP3 IPO7	7.73e-04	302	18	3	EFO_0004704
Disease	basophil percentage of granulocytes	ATP8B4 LMO4	1.16e-03	83	18	2	EFO_0007995
Disease	Hypermetropia	ALMS1 MTAP	1.78e-03	103	18	2	HP_0000540
Disease	lung adenocarcinoma	ATP8B4 MTAP	4.97e-03	174	18	2	EFO_0000571
Disease	age at menarche	ALMS1 METTL15 FAAH2	5.29e-03	594	18	3	EFO_0004703

Protein segments in the cluster

Peptide	Gene	Start	Entry
KYRAKCSMLFHYDWI	BEST4	216	Q8NFU0
CDRYDDLCSYMSWKT	ALMS1	336	Q8TCU4
HGRWSYFRMCKFLCY	ATP8B4	861	Q8TF62
CYASIAMATDYDCWK	MTAP	211	Q13126
DMKYLYRACKFAEWC	LANCL1	341	O43813
LYAMDSYWHSRCLKC	LMO4	36	P61968
YMRARACWVLHYFCE	IPO7	471	O95373
AYALKTWAHCMSYSN	KISS1R	301	Q969F8
YFCRMYKECLSCWLE	METTL15P1	6	P0C7V9
YFCRMYKECLSCWLE	METTL15	6	A6NJ78
KYRNFSYLHCKWATM	CHD6	321	Q8TD26
CSELCMWYESSNKIY	FAAH2	176	Q6GMR7
LYYNAEASMCHRWSR	FAM180A	11	Q6UWF9
YYWRIKKFHDACLDM	GPR63	371	Q9BZJ6
YMSLAGWTCRDDCKY	PGAP3	56	Q96FM1
LSWEYYSMFQCKAHL	TAF2	441	Q6P1X5
SLAWYPCMLKYCHSR	OAF	221	Q86UD1
DYMCTECGYVTKWKH	ZNF142	456	P52746
YFHCKDCKTRWESAY	ZAR1L	226	A6NP61