Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	four-way junction helicase activity	BLM WRN FANCM	1.94e-06	6	93	3	GO:0009378
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	KIF20A BLM ORC4 RRAGA CFTR LRRK2 WRN BTAF1 RRAGB FANCM DDX39A DNAH8 DDX39B MFN1	1.35e-05	775	93	14	GO:0017111
GeneOntologyMolecularFunction	forked DNA-dependent helicase activity	BLM WRN	2.15e-05	2	93	2	GO:0061749
GeneOntologyMolecularFunction	ATP-dependent activity	KIF20A BLM ORC4 ATP6V1B2 MYO7B CFTR WRN BTAF1 FANCM DDX39A DNAH8 DDX39B	2.76e-05	614	93	12	GO:0140657
GeneOntologyMolecularFunction	pyrophosphatase activity	KIF20A BLM ORC4 RRAGA CFTR LRRK2 WRN BTAF1 RRAGB FANCM DDX39A DNAH8 DDX39B MFN1	3.25e-05	839	93	14	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	KIF20A BLM ORC4 RRAGA CFTR LRRK2 WRN BTAF1 RRAGB FANCM DDX39A DNAH8 DDX39B MFN1	3.29e-05	840	93	14	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	KIF20A BLM ORC4 RRAGA CFTR LRRK2 WRN BTAF1 RRAGB FANCM DDX39A DNAH8 DDX39B MFN1	3.29e-05	840	93	14	GO:0016818
GeneOntologyMolecularFunction	ATP hydrolysis activity	KIF20A BLM ORC4 CFTR WRN BTAF1 FANCM DDX39A DNAH8 DDX39B	3.93e-05	441	93	10	GO:0016887
GeneOntologyMolecularFunction	3'-5' DNA helicase activity	BLM WRN FANCM	5.24e-05	16	93	3	GO:0043138
GeneOntologyMolecularFunction	8-hydroxy-2'-deoxyguanosine DNA binding	BLM WRN	6.42e-05	3	93	2	GO:1905773
GeneOntologyMolecularFunction	telomeric G-quadruplex DNA binding	BLM WRN	6.42e-05	3	93	2	GO:0061849
GeneOntologyMolecularFunction	four-way junction DNA binding	BLM WRN FANCM	8.98e-05	19	93	3	GO:0000400
GeneOntologyMolecularFunction	helicase activity	BLM WRN BTAF1 FANCM DDX39A DDX39B	9.64e-05	158	93	6	GO:0004386
GeneOntologyMolecularFunction	Y-form DNA binding	BLM WRN	1.28e-04	4	93	2	GO:0000403
GeneOntologyMolecularFunction	telomeric D-loop binding	BLM WRN	1.28e-04	4	93	2	GO:0061821
GeneOntologyMolecularFunction	molecular adaptor activity	TGFBR2 PRAMEF7 AMFR PTPN14 BRDT RRAGA ANKRD1 ITSN2 LRRK2 MED14 BTAF1 MED13L PRAMEF8 SETD3 SPATA2 FBXL2 NMD3	1.56e-04	1356	93	17	GO:0060090
GeneOntologyMolecularFunction	tubulin binding	KIF20A PDE4B NF1 CENPF TTLL9 LRRK2 FES FHDC1 PRC1	1.72e-04	428	93	9	GO:0015631
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	PRAMEF7 AMFR PTPN14 BRDT RRAGA ANKRD1 LRRK2 MED14 BTAF1 MED13L PRAMEF8 SETD3 SPATA2 FBXL2 NMD3	2.89e-04	1160	93	15	GO:0030674
GeneOntologyMolecularFunction	D-loop DNA binding	BLM WRN	3.18e-04	6	93	2	GO:0062037
GeneOntologyMolecularFunction	bubble DNA binding	BLM WRN	5.90e-04	8	93	2	GO:0000405
GeneOntologyMolecularFunction	microtubule binding	KIF20A NF1 CENPF LRRK2 FES FHDC1 PRC1	5.92e-04	308	93	7	GO:0008017
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	TBC1D4 NF1 DOCK8 RABGAP1L ITSN2 LRRK2 ARHGEF9 RIMS1 HERC1	5.94e-04	507	93	9	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	TBC1D4 NF1 DOCK8 RABGAP1L ITSN2 LRRK2 ARHGEF9 RIMS1 HERC1	5.94e-04	507	93	9	GO:0030695
GeneOntologyMolecularFunction	DNA secondary structure binding	BLM WRN FANCM	9.17e-04	41	93	3	GO:0000217
GeneOntologyMolecularFunction	oxidized purine DNA binding	BLM WRN	9.42e-04	10	93	2	GO:0032357
GeneOntologyMolecularFunction	oxidized DNA binding	BLM WRN	1.15e-03	11	93	2	GO:0032356
GeneOntologyMolecularFunction	GTPase binding	NCKAP1 RABGAP1L LRRK2 RRAGB RIMS1 USP33 XPOT	1.47e-03	360	93	7	GO:0051020
GeneOntologyMolecularFunction	cytoskeletal protein binding	KIF20A PDE4B NF1 MYLK CENPF MYO7B TTLL9 ANKRD1 LRRK2 FES FHDC1 PRC1 SETD3	1.71e-03	1099	93	13	GO:0008092
GeneOntologyMolecularFunction	G-quadruplex DNA binding	BLM WRN	1.88e-03	14	93	2	GO:0051880
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	BLM WRN BTAF1 FANCM	2.95e-03	127	93	4	GO:0008094
GeneOntologyMolecularFunction	DNA helicase activity	BLM WRN FANCM	3.03e-03	62	93	3	GO:0003678
GeneOntologyMolecularFunction	ubiquitin-specific protease binding	AMFR SPATA2	3.86e-03	20	93	2	GO:1990381
GeneOntologyMolecularFunction	small GTPase binding	NCKAP1 RABGAP1L LRRK2 RIMS1 USP33 XPOT	3.89e-03	321	93	6	GO:0031267
GeneOntologyMolecularFunction	3',5'-cyclic-AMP phosphodiesterase activity	PDE4B PDE6B	4.67e-03	22	93	2	GO:0004115
GeneOntologyBiologicalProcess	establishment of RNA localization	TGFBR2 NUP188 ATM DDX39A DDX39B THOC5 XPOT	1.61e-05	178	93	7	GO:0051236
GeneOntologyBiologicalProcess	nuclear export	PTPN14 NUP188 DDX39A DDX39B THOC5 XPOT NMD3	2.06e-05	185	93	7	GO:0051168
GeneOntologyBiologicalProcess	organelle fission	ORC4 SEC16B NCAPD3 BRDT CENPF TOM1L1 LRRK2 ATM PRC1 FANCM MFN1	5.20e-05	571	93	11	GO:0048285
GeneOntologyBiologicalProcess	nuclear transport	PTPN14 NF1 LRRK2 NUP188 DDX39A DDX39B THOC5 XPOT NMD3	5.26e-05	378	93	9	GO:0051169
GeneOntologyBiologicalProcess	nucleocytoplasmic transport	PTPN14 NF1 LRRK2 NUP188 DDX39A DDX39B THOC5 XPOT NMD3	5.26e-05	378	93	9	GO:0006913
GeneOntologyBiologicalProcess	RNA localization	TGFBR2 NUP188 ATM DDX39A DDX39B THOC5 XPOT	5.70e-05	217	93	7	GO:0006403
GeneOntologyBiologicalProcess	RNA export from nucleus	NUP188 DDX39A DDX39B THOC5 XPOT	7.39e-05	96	93	5	GO:0006405
GeneOntologyBiologicalProcess	RNA transport	TGFBR2 NUP188 DDX39A DDX39B THOC5 XPOT	1.42e-04	175	93	6	GO:0050658
GeneOntologyBiologicalProcess	nucleic acid transport	TGFBR2 NUP188 DDX39A DDX39B THOC5 XPOT	1.42e-04	175	93	6	GO:0050657
GeneOntologyBiologicalProcess	response to camptothecin	BLM SPIDR	1.99e-04	5	93	2	GO:1901563
GeneOntologyBiologicalProcess	cellular response to camptothecin	BLM SPIDR	1.99e-04	5	93	2	GO:0072757
GeneOntologyCellularComponent	Gtr1-Gtr2 GTPase complex	RRAGA RRAGB	1.19e-04	4	94	2	GO:1990131
GeneOntologyCellularComponent	microvillus	ATP6V1B2 MYO7B CFTR LRRK2 VCAM1	2.35e-04	123	94	5	GO:0005902
Domain	-	BLM ORC4 ATP6V1B2 CHST15 MYO7B RRAGA CFTR LRRK2 WRN BTAF1 RRAGB FANCM DDX39A DNAH8 DDX39B MFN1	4.85e-07	746	90	16	3.40.50.300
Domain	P-loop_NTPase	KIF20A BLM ORC4 ATP6V1B2 CHST15 MYO7B RRAGA CFTR LRRK2 WRN BTAF1 RRAGB FANCM DDX39A DNAH8 DDX39B MFN1	5.21e-07	848	90	17	IPR027417
Domain	ARM-type_fold	NCAPD3 NF1 DOCK8 UNC45B LRRK2 SERAC1 BTAF1 NUP188 ATM XPOT	5.37e-06	339	90	10	IPR016024
Domain	Helicase_C	BLM WRN BTAF1 FANCM DDX39A DDX39B	1.29e-05	107	90	6	PF00271
Domain	HELICc	BLM WRN BTAF1 FANCM DDX39A DDX39B	1.29e-05	107	90	6	SM00490
Domain	Helicase_C	BLM WRN BTAF1 FANCM DDX39A DDX39B	1.36e-05	108	90	6	IPR001650
Domain	HELICASE_CTER	BLM WRN BTAF1 FANCM DDX39A DDX39B	1.44e-05	109	90	6	PS51194
Domain	HELICASE_ATP_BIND_1	BLM WRN BTAF1 FANCM DDX39A DDX39B	1.44e-05	109	90	6	PS51192
Domain	DEXDc	BLM WRN BTAF1 FANCM DDX39A DDX39B	1.44e-05	109	90	6	SM00487
Domain	Helicase_ATP-bd	BLM WRN BTAF1 FANCM DDX39A DDX39B	1.52e-05	110	90	6	IPR014001
Domain	RQC	BLM WRN	2.30e-05	2	90	2	SM00956
Domain	DEAD/DEAH_box_helicase_dom	BLM WRN FANCM DDX39A DDX39B	2.69e-05	73	90	5	IPR011545
Domain	DEAD	BLM WRN FANCM DDX39A DDX39B	2.69e-05	73	90	5	PF00270
Domain	ARM-like	NCAPD3 NF1 DOCK8 UNC45B LRRK2 SERAC1 BTAF1 XPOT	4.79e-05	270	90	8	IPR011989
Domain	-	BLM WRN	6.87e-05	3	90	2	1.10.150.80
Domain	HRDC	BLM WRN	6.87e-05	3	90	2	SM00341
Domain	RQC	BLM WRN	6.87e-05	3	90	2	PF09382
Domain	HRDC	BLM WRN	6.87e-05	3	90	2	PF00570
Domain	RQC_domain	BLM WRN	6.87e-05	3	90	2	IPR018982
Domain	HRDC	BLM WRN	6.87e-05	3	90	2	PS50967
Domain	-	NCAPD3 NF1 UNC45B LRRK2 SERAC1 BTAF1 XPOT	9.87e-05	222	90	7	1.25.10.10
Domain	RecQ_Zn-bd	BLM WRN	1.37e-04	4	90	2	IPR032284
Domain	Gtr1_RagA	RRAGA RRAGB	1.37e-04	4	90	2	PF04670
Domain	Gtr1_RagA	RRAGA RRAGB	1.37e-04	4	90	2	IPR006762
Domain	HRDC_dom	BLM WRN	1.37e-04	4	90	2	IPR002121
Domain	RecQ_Zn_bind	BLM WRN	1.37e-04	4	90	2	PF16124
Domain	HRDC-like	BLM WRN	2.27e-04	5	90	2	IPR010997
Domain	DNA_helicase_ATP-dep_RecQ	BLM WRN	2.27e-04	5	90	2	IPR004589
Domain	PID	TBC1D4 RABGAP1L APBA1	3.25e-04	28	90	3	PF00640
Domain	PID	TBC1D4 RABGAP1L APBA1	4.85e-04	32	90	3	PS01179
Domain	-	PTPN14 TBC1D4 MYO7B RABGAP1L ITSN2 ARHGEF9 APBA1 OSBPL9	5.97e-04	391	90	8	2.30.29.30
Domain	DEAH_ATP_HELICASE	BLM WRN FANCM	8.08e-04	38	90	3	PS00690
Domain	PTB	TBC1D4 RABGAP1L APBA1	9.40e-04	40	90	3	SM00462
Domain	PTB/PI_dom	TBC1D4 RABGAP1L APBA1	1.01e-03	41	90	3	IPR006020
Domain	PH_dom-like	PTPN14 TBC1D4 MYO7B RABGAP1L ITSN2 ARHGEF9 APBA1 OSBPL9	1.04e-03	426	90	8	IPR011993
Domain	TPR	UNC45B TTC21B GTF3C3 NAA16	3.51e-03	129	90	4	SM00028
Domain	PRAME_family	PRAMEF7 PRAMEF8	3.72e-03	19	90	2	IPR026271
Domain	PDEase	PDE4B PDE6B	3.72e-03	19	90	2	IPR023088
Domain	TPR_repeat	UNC45B TTC21B GTF3C3 NAA16	3.91e-03	133	90	4	IPR019734
Domain	PDEase_I	PDE4B PDE6B	4.54e-03	21	90	2	PF00233
Domain	PDEASE_I	PDE4B PDE6B	4.54e-03	21	90	2	PS00126
Domain	PDEase_CS	PDE4B PDE6B	4.54e-03	21	90	2	IPR023174
Pathway	REACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES	BLM WRN ATM SPIDR	2.91e-05	35	72	4	MM15293
Pathway	REACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES	BLM WRN ATM SPIDR	3.64e-05	37	72	4	M27583
Pathway	REACTOME_HDR_THROUGH_HOMOLOGOUS_RECOMBINATION_HRR	BLM WRN ATM SPIDR	2.30e-04	59	72	4	MM15283
Pathway	WP_PRIMARY_OVARIAN_INSUFFICIENCY	BLM TGFBR2 WRN ATM SPIDR FANCM	2.58e-04	174	72	6	M48058
Pathway	REACTOME_HOMOLOGOUS_DNA_PAIRING_AND_STRAND_EXCHANGE	BLM WRN ATM	3.05e-04	26	72	3	MM15297
Pathway	REACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES_THROUGH_SYNTHESIS_DEPENDENT_STRAND_ANNEALING_SDSA	BLM WRN ATM	3.42e-04	27	72	3	M27586
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	MYLK NCKAP1 CENPF DOCK8 PPP1R12B CFTR ITSN2 ARHGEF9 PRC1 DDX39B MFN1	4.22e-04	649	72	11	MM15690
Pathway	REACTOME_HDR_THROUGH_HOMOLOGOUS_RECOMBINATION_HRR	BLM WRN ATM SPIDR	4.45e-04	70	72	4	M27570
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	BLM NCAPD3 CENPF WRN MED14 ATM MED13L PRC1 FANCM DDX39B GTF3C3	4.74e-08	453	95	11	29656893
Pubmed	Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B.	CHST15 RRAGA RRAGB	3.93e-07	6	95	3	11073942
Pubmed	TREX is a conserved complex coupling transcription with messenger RNA export.	DDX39A DDX39B THOC5	6.86e-07	7	95	3	11979277
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	BLM TGFBR2 ORC4 NCAPD3 NF1 PPP1R12B RABGAP1L TOM1L1 BTAF1 NUP188 ATM HERC1 DDX39B XPOT	1.14e-06	1061	95	14	33845483
Pubmed	Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair.	BLM SPIDR FANCM	2.34e-06	10	95	3	23509288
Pubmed	Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.	ATP6V1B2 RRAGA RRAGB	3.21e-06	11	95	3	25567906
Pubmed	Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study.	PDE4B CFTR WRN	3.21e-06	11	95	3	17903301
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	KIF20A BLM NF1 MED14 NUP188 PRC1 ZBTB11 DDX39B GTF3C3	3.44e-06	440	95	9	34244565
Pubmed	EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired.	AMFR RRAGA ATM HERC1 MFN1 USP33	3.69e-06	150	95	6	32423001
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	PRAMEF7 MED14 OSBPL9 CACNA1G PRAMEF8 DDX39B USP33 XPOT	7.19e-06	363	95	8	14691545
Pubmed	Nuclear localization of poly(A)+ mRNA following siRNA reduction of expression of the mammalian RNA helicases UAP56 and URH49.	DDX39A DDX39B	7.38e-06	2	95	2	16949217
Pubmed	The Werner and Bloom syndrome proteins catalyze regression of a model replication fork.	BLM WRN	7.38e-06	2	95	2	17115688
Pubmed	Binding of the human cytomegalovirus (HCMV) tegument protein UL69 to UAP56/URH49 is not required for efficient replication of HCMV.	DDX39A DDX39B	7.38e-06	2	95	2	20610707
Pubmed	WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks.	WRN ATM	7.38e-06	2	95	2	18596239
Pubmed	Structural differences between the closely related RNA helicases, UAP56 and URH49, fashion distinct functional apo-complexes.	DDX39A DDX39B	7.38e-06	2	95	2	38225262
Pubmed	Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins.	BLM WRN	7.38e-06	2	95	2	11919194
Pubmed	Defects in telomere maintenance molecules impair osteoblast differentiation and promote osteoporosis.	BLM WRN	7.38e-06	2	95	2	18028256
Pubmed	Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs.	BLM WRN	7.38e-06	2	95	2	10871376
Pubmed	BLM helicase facilitates telomere replication during leading strand synthesis of telomeres.	BLM WRN	7.38e-06	2	95	2	26195664
Pubmed	An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5.	ATM THOC5	7.38e-06	2	95	2	21937706
Pubmed	Parsing the roles of DExD-box proteins DDX39A and DDX39B in alternative RNA splicing.	DDX39A DDX39B	7.38e-06	2	95	2	38801080
Pubmed	Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases.	RRAGA RRAGB	7.38e-06	2	95	2	7499430
Pubmed	NF1 patient missense variants predict a role for ATM in modifying neurofibroma initiation.	NF1 ATM	7.38e-06	2	95	2	31664505
Pubmed	Distinct functions of human RECQ helicases WRN and BLM in replication fork recovery and progression after hydroxyurea-induced stalling.	BLM WRN	7.38e-06	2	95	2	23253856
Pubmed	The Werner and Bloom syndrome proteins help resolve replication blockage by converting (regressed) holliday junctions to functional replication forks.	BLM WRN	7.38e-06	2	95	2	21736299
Pubmed	Terminal regions of UAP56 and URH49 are required for their distinct complex formation functioning to an essential role in mRNA processing and export.	DDX39A DDX39B	7.38e-06	2	95	2	38377942
Pubmed	Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes.	BLM WRN	7.38e-06	2	95	2	15367665
Pubmed	Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM.	BLM ATM	7.38e-06	2	95	2	12034743
Pubmed	Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands.	BLM WRN	7.38e-06	2	95	2	11735402
Pubmed	RNA structure is a key regulatory element in pathological ATM and CFTR pseudoexon inclusion events.	CFTR ATM	7.38e-06	2	95	2	17580311
Pubmed	Competition between the DNA unwinding and strand pairing activities of the Werner and Bloom syndrome proteins.	BLM WRN	7.38e-06	2	95	2	16412221
Pubmed	Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo.	MYLK CFTR	7.38e-06	2	95	2	16184195
Pubmed	The roles of WRN and BLM RecQ helicases in the Alternative Lengthening of Telomeres.	BLM WRN	7.38e-06	2	95	2	22989712
Pubmed	The Werner syndrome protein is distinguished from the Bloom syndrome protein by its capacity to tightly bind diverse DNA structures.	BLM WRN	7.38e-06	2	95	2	22272300
Pubmed	The closely related RNA helicases, UAP56 and URH49, preferentially form distinct mRNA export machineries and coordinately regulate mitotic progression.	DDX39A DDX39B	7.38e-06	2	95	2	20573985
Pubmed	The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases.	BLM WRN	7.38e-06	2	95	2	11433031
Pubmed	RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway.	RRAGA RRAGB	7.38e-06	2	95	2	9394008
Pubmed	Bloom's syndrome: Why not premature aging?: A comparison of the BLM and WRN helicases.	BLM WRN	7.38e-06	2	95	2	27238185
Pubmed	RecQ family members combine strand pairing and unwinding activities to catalyze strand exchange.	BLM WRN	7.38e-06	2	95	2	15845538
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	NCAPD3 NF1 BTAF1 ATM XPOT	1.02e-05	104	95	5	31240132
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	BLM TPP2 NF1 NCKAP1 CENPF NUP188 ATM ZBTB11 GTF3C3 XPOT	1.23e-05	653	95	10	22586326
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	KIF20A BLM CENPF PPP1R12B ITSN2 NUP188 ATM PRC1 DDX39A DDX39B GTF3C3 TRUB2 NAA16	1.57e-05	1155	95	13	20360068
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CHST15 NCKAP1 RABGAP1L ITSN2 ARHGEF9 MED13L SPATA2 USP33	1.64e-05	407	95	8	12693553
Pubmed	Nuclear structure in normal and Bloom syndrome cells.	BLM WRN	2.21e-05	3	95	2	10779560
Pubmed	Murine leukemia virus uses TREX components for efficient nuclear export of unspliced viral transcripts.	DDX39B THOC5	2.21e-05	3	95	2	24618812
Pubmed	Stimulation of flap endonuclease-1 by the Bloom's syndrome protein.	BLM WRN	2.21e-05	3	95	2	14688284
Pubmed	Metabolism. Differential regulation of mTORC1 by leucine and glutamine.	RRAGA RRAGB	2.21e-05	3	95	2	25567907
Pubmed	Single-molecule imaging reveals a common mechanism shared by G-quadruplex-resolving helicases.	BLM WRN	2.21e-05	3	95	2	27407146
Pubmed	USP37 regulates DNA damage response through stabilizing and deubiquitinating BLM.	BLM ATM	2.21e-05	3	95	2	34606619
Pubmed	Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality.	BLM WRN	2.21e-05	3	95	2	17961633
Pubmed	Formation of 53BP1 foci and ATM activation under oxidative stress is facilitated by RNA:DNA hybrids and loss of ATM-53BP1 expression promotes photoreceptor cell survival in mice.	PDE6B ATM	2.21e-05	3	95	2	30345028
Pubmed	FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres.	BLM FANCM	2.21e-05	3	95	2	28673972
Pubmed	Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases.	BLM WRN	2.21e-05	3	95	2	27612385
Pubmed	Growth-regulated expression and G0-specific turnover of the mRNA that encodes URH49, a mammalian DExH/D box protein that is highly related to the mRNA export protein UAP56.	DDX39A DDX39B	2.21e-05	3	95	2	15047853
Pubmed	Colorectal cancer and polymorphisms in DNA repair genes WRN, RMI1 and BLM.	BLM WRN	2.21e-05	3	95	2	19945966
Pubmed	POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates.	BLM WRN	2.21e-05	3	95	2	16030011
Pubmed	DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells.	BLM WRN	2.21e-05	3	95	2	25122754
Pubmed	ATM pathway activation limits R-loop-associated genomic instability in Werner syndrome cells.	WRN ATM	2.21e-05	3	95	2	30657978
Pubmed	RagA, but not RagB, is essential for embryonic development and adult mice.	RRAGA RRAGB	2.21e-05	3	95	2	24768164
Pubmed	Delineation of WRN helicase function with EXO1 in the replicational stress response.	BLM WRN	2.21e-05	3	95	2	20447876
Pubmed	DNA Damage Activates TGF-β Signaling via ATM-c-Cbl-Mediated Stabilization of the Type II Receptor TβRII.	TGFBR2 ATM	2.21e-05	3	95	2	31315051
Pubmed	Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1.	BLM WRN	2.21e-05	3	95	2	19734539
Pubmed	The processing of Holliday junctions by BLM and WRN helicases is regulated by p53.	BLM WRN	2.21e-05	3	95	2	12080066
Pubmed	The RNA helicase DDX39B and its paralog DDX39A regulate androgen receptor splice variant AR-V7 generation.	DDX39A DDX39B	2.21e-05	3	95	2	28025139
Pubmed	HERC2 inactivation abrogates nucleolar localization of RecQ helicases BLM and WRN.	BLM WRN	2.21e-05	3	95	2	33432007
Pubmed	A polymorphism in Werner syndrome gene is associated with breast cancer susceptibility in Chinese women.	BLM WRN	2.21e-05	3	95	2	19205873
Pubmed	Hcc-1 is a novel component of the nuclear matrix with growth inhibitory function.	DDX39A DDX39B	2.21e-05	3	95	2	15338056
Pubmed	DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function.	BLM WRN	2.21e-05	3	95	2	25921537
Pubmed	Regulation of mitophagy by the Gp78 E3 ubiquitin ligase.	AMFR MFN1	2.21e-05	3	95	2	23427266
Pubmed	The risk for developing cancer in Israeli ATM, BLM, and FANCC heterozygous mutation carriers.	BLM ATM	2.21e-05	3	95	2	26778106
Pubmed	Interferon-induced antiviral protein MxA interacts with the cellular RNA helicases UAP56 and URH49.	DDX39A DDX39B	2.21e-05	3	95	2	21859714
Pubmed	ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response.	WRN ATM	2.21e-05	3	95	2	10839545
Pubmed	Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance.	RRAGA RRAGB	2.21e-05	3	95	2	31649036
Pubmed	Functional interaction of p53 and BLM DNA helicase in apoptosis.	BLM WRN	2.21e-05	3	95	2	11399766
Pubmed	Rag GTPases are cardioprotective by regulating lysosomal function.	RRAGA RRAGB	2.21e-05	3	95	2	24980141
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	TPP2 NCAPD3 NCKAP1 CENPF MED14 NUP188 CMAS DDX39A DNAH8 DDX39B	2.33e-05	704	95	10	29955894
Pubmed	Phosphoproteome analysis of the human mitotic spindle.	KIF20A BLM NCAPD3 NF1 CENPF PRC1	2.51e-05	210	95	6	16565220
Pubmed	ETAA1 acts at stalled replication forks to maintain genome integrity.	BLM WRN FANCM	2.53e-05	21	95	3	27723720
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	BLM NCAPD3 CENPF WRN MED14 PRC1 ZBTB11 CMAS DDX39A GTF3C3	4.40e-05	759	95	10	35915203
Pubmed	LRRK2 interacts with ATM and regulates Mdm2-p53 cell proliferation axis in response to genotoxic stress.	LRRK2 ATM	4.41e-05	4	95	2	28973420
Pubmed	Endogenous gamma-H2AX-ATM-Chk2 checkpoint activation in Bloom's syndrome helicase deficient cells is related to DNA replication arrested forks.	BLM ATM	4.41e-05	4	95	2	17634426
Pubmed	ATR and ATM-dependent movement of BLM helicase during replication stress ensures optimal ATM activation and 53BP1 focus formation.	BLM ATM	4.41e-05	4	95	2	15539948
Pubmed	Genome instability and transcription elongation impairment in human cells depleted of THO/TREX.	DDX39B THOC5	4.41e-05	4	95	2	22144908
Pubmed	Differential regulation of CFTRDeltaF508 degradation by ubiquitin ligases gp78 and Hrd1.	AMFR CFTR	4.41e-05	4	95	2	19828134
Pubmed	The associations between single nucleotide polymorphisms of DNA repair genes, DNA damage, and age-related cataract: Jiangsu Eye Study.	BLM WRN	4.41e-05	4	95	2	23322570
Pubmed	YAP plays a crucial role in the development of cardiomyopathy in lysosomal storage diseases.	RRAGA RRAGB	4.41e-05	4	95	2	33373332
Pubmed	ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex.	DDX39A DDX39B	4.41e-05	4	95	2	20844015
Pubmed	Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases.	BLM WRN	4.41e-05	4	95	2	12181313
Pubmed	The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA.	BLM WRN	4.41e-05	4	95	2	16326861
Pubmed	The BAT1 gene in the MHC encodes an evolutionarily conserved putative nuclear RNA helicase of the DEAD family.	DDX39A DDX39B	4.41e-05	4	95	2	7601445
Pubmed	5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.	NF1 ATM XPOT	5.51e-05	27	95	3	23027611
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	BLM ORC4 ATP6V1B2 NCAPD3 NCKAP1 PTCD1 PPP1R12B ITSN2 ARHGEF9 WRN MED14 ZBTB11 CMAS TEKT5	5.51e-05	1497	95	14	31527615
Pubmed	The cAMP-phosphodiesterase 4 (PDE4) controls β-adrenoceptor- and CFTR-dependent saliva secretion in mice.	PDE4B CFTR	7.34e-05	5	95	2	33944911
Pubmed	Lens-specific expression of transforming growth factor beta1 in transgenic mice causes anterior subcapsular cataracts.	TGFBR2 PDE6B	7.34e-05	5	95	2	9449696
Pubmed	RecQ helicase expression in patients with telomeropathies.	BLM WRN	7.34e-05	5	95	2	38874681
Pubmed	The cellular DExD/H-box RNA-helicases UAP56 and URH49 exhibit a CRM1-independent nucleocytoplasmic shuttling activity.	DDX39A DDX39B	7.34e-05	5	95	2	21799930
Pubmed	RecQ helicases: suppressors of tumorigenesis and premature aging.	BLM WRN	7.34e-05	5	95	2	12803543
Pubmed	The many substrates and functions of ATM.	WRN ATM	7.34e-05	5	95	2	11252893
Pubmed	Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases.	BLM WRN	7.34e-05	5	95	2	15965237
Pubmed	SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling.	RRAGA RRAGB	7.34e-05	5	95	2	22575674
Interaction	CTDP1 interactions	KIF20A NCAPD3 NF1 MED14 BTAF1 ATM PRC1 XPOT	3.75e-06	207	89	8	int:CTDP1
Interaction	TOP3A interactions	BLM LINC01565 NF1 WRN SPIDR FANCM	1.14e-05	114	89	6	int:TOP3A
Interaction	MYL9 interactions	KIF20A MYLK CFTR LRRK2 PRC1	1.17e-05	67	89	5	int:MYL9
Interaction	SLC38A9 interactions	ATP6V1B2 RRAGA RRAGB DDX39A	1.68e-05	35	89	4	int:SLC38A9
Interaction	CALM1 interactions	KIF20A TPP2 AMFR NCAPD3 TBC1D4 MYLK CFTR LRRK2 OSBPL9 PRC1 FBXL2 DDX39B	1.94e-05	626	89	12	int:CALM1
Interaction	MYL12B interactions	KIF20A MYLK LRRK2 PRC1 DDX39A DDX39B	3.37e-05	138	89	6	int:MYL12B
Interaction	PPP1R13L interactions	KIF20A AMFR PPP1R12B CFTR PRC1	4.40e-05	88	89	5	int:PPP1R13L
Interaction	PDPN interactions	ORC4 TOM1L1 DDX39A	5.41e-05	17	89	3	int:PDPN
Interaction	NHS interactions	NCKAP1 CFTR PTPRU DDX39A	5.96e-05	48	89	4	int:NHS
Interaction	FOXG1 interactions	KIF20A NCAPD3 BTAF1 DDX39A GTF3C3	6.36e-05	95	89	5	int:FOXG1
Interaction	HERC2 interactions	KIF20A BLM LRRK2 WRN MED14 HERC1 DDX39A DDX39B THOC5 USP33	7.47e-05	503	89	10	int:HERC2
Interaction	CSE1L interactions	TPP2 AMFR ATP6V1B2 CFTR LRRK2 RRAGB PTPRU VCAM1	7.51e-05	314	89	8	int:CSE1L
Interaction	PPP1R12A interactions	KIF20A TPP2 MYLK PPP1R12B CFTR LRRK2 PRC1 DDX39B	8.95e-05	322	89	8	int:PPP1R12A
Interaction	TMOD3 interactions	KIF20A ATP6V1B2 TBC1D4 CFTR LRRK2 PRC1 DDX39B	1.01e-04	243	89	7	int:TMOD3
Interaction	AARS1 interactions	CFTR TOM1L1 LRRK2 PRC1 VCAM1 NMD3	1.11e-04	171	89	6	int:AARS1
Interaction	ACRV1 interactions	CFTR DDX39A	1.15e-04	4	89	2	int:ACRV1
Interaction	PLEC interactions	KIF20A NCAPD3 CFTR LRRK2 FES PRC1 FANCM DDX39B VCAM1	1.19e-04	430	89	9	int:PLEC
Interaction	CNTNAP4 interactions	KIF20A APBA1 PRC1	1.21e-04	22	89	3	int:CNTNAP4
Interaction	CILK1 interactions	BLM TPP2 NUP188 DDX39A	1.26e-04	58	89	4	int:CILK1
Interaction	MYL6 interactions	KIF20A MYLK CFTR LRRK2 PRC1 DDX39B VCAM1	1.36e-04	255	89	7	int:MYL6
Interaction	PCMT1 interactions	KIF20A ATP6V1B2 DOCK8 CFTR LRRK2 PRC1 VCAM1	1.40e-04	256	89	7	int:PCMT1
Interaction	HSPD1 interactions	KIF20A AMFR PDE4B PTPN14 PTCD1 CFTR LRRK2 MED13L PRC1 FBXL2 CMAS DDX39B TRUB2 VCAM1	1.48e-04	1022	89	14	int:HSPD1
Interaction	SPIDR interactions	BLM SPIDR FANCM	1.58e-04	24	89	3	int:SPIDR
Interaction	RMI2 interactions	BLM SPIDR FANCM	1.78e-04	25	89	3	int:RMI2
Interaction	FANCM interactions	BLM LRRK2 SPIDR FANCM	1.84e-04	64	89	4	int:FANCM
Interaction	OR5M8 interactions	UNC45B CFTR	1.91e-04	5	89	2	int:OR5M8
Interaction	SPATA31H1 interactions	PRC1 DDX39A	1.91e-04	5	89	2	int:SPATA31H1
Cytoband	15q26.1	BLM FES PRC1	1.97e-04	54	95	3	15q26.1
GeneFamily	RecQ like helicases	BLM WRN	1.04e-04	5	59	2	1049
Coexpression	GSE24026_PD1_LIGATION_VS_CTRL_IN_ACT_TCELL_LINE_DN	KIF20A NCAPD3 TBC1D4 WRN HERC1 PRC1 ZNF236	7.92e-06	200	94	7	M4538
Coexpression	SOTIRIOU_BREAST_CANCER_GRADE_1_VS_3_UP	KIF20A BLM CENPF PRC1 DDX39A XPOT	1.98e-05	154	94	6	M3766
Coexpression	WANG_TARGETS_OF_MLL_CBP_FUSION_UP	ITSN2 DNAH8 TRUB2 VCAM1	2.06e-05	45	94	4	M1440
Coexpression	WANG_TARGETS_OF_MLL_CBP_FUSION_UP	ITSN2 DNAH8 TRUB2 VCAM1	3.68e-05	52	94	4	MM628
Coexpression	GSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP	NF1 DOCK8 PPP1R12B WRN ATM HERC1	4.76e-05	180	94	6	M8239
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	BLM TGFBR2 NCKAP1 CENPF RABGAP1L ITSN2 WRN BTAF1 SPIDR MED13L SETD3 ZBTB11	5.58e-05	856	94	12	M4500
Coexpression	GSE7218_IGM_VS_IGG_SIGNAL_THGOUGH_ANTIGEN_BCELL_UP	BLM PTPN14 CENPF ANO10 CMAS TRUB2	5.89e-05	187	94	6	M6807
Coexpression	GSE35543_IN_VIVO_NTREG_VS_IN_VITRO_ITREG_DN	PDE4B OR7E24 DRP2 RABGAP1L RRAGB ANO10	6.43e-05	190	94	6	M9428
Coexpression	WEST_ADRENOCORTICAL_TUMOR_MARKERS_UP	KIF20A PDE4B PRC1	6.55e-05	22	94	3	M205
Coexpression	GSE13738_RESTING_VS_BYSTANDER_ACTIVATED_CD4_TCELL_UP	TGFBR2 STK17A ATM HERC1 MED13L NAA16	7.22e-05	194	94	6	M3321
Coexpression	GSE24142_DN2_VS_DN3_THYMOCYTE_ADULT_DN	TPP2 NCKAP1 BRDT SERAC1 HERC1 ANKS3	8.30e-05	199	94	6	M4567
CoexpressionAtlas	dev gonad_e12.5_F_GermCellOvary_Oct_top-relative-expression-ranked_1000	BLM NCAPD3 BRDT CENPF CARNMT1 RRAGB NUP188 ATM METTL25 PRC1 SETD3 FANCM DDX39A DNAH8 GTF3C3 XPOT NMD3 NAA16	4.94e-09	822	87	18	gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_1000
CoexpressionAtlas	dev gonad_e12.5_M_GermCellTestis_Oct_top-relative-expression-ranked_1000	KIF20A BLM NCAPD3 BRDT CENPF C10orf53 RRAGB NUP188 ATM METTL25 PRC1 GTF3C3 XPOT NMD3 NAA16	7.46e-07	795	87	15	gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_1000
CoexpressionAtlas	dev gonad_e11.5_F_PrimGermCell_Oct_top-relative-expression-ranked_1000	KIF20A BLM NCAPD3 CENPF CARNMT1 RRAGB NUP188 ATM PRC1 SETD3 DDX39A DNAH8 GTF3C3 XPOT NMD3	7.94e-07	799	87	15	gudmap_dev gonad_e11.5_F_PrimGermCell_Oct_1000
CoexpressionAtlas	dev gonad_e13.5_M_GermCell_Oct_k-means-cluster#1_top-relative-expression-ranked_1000	BLM NCAPD3 CENPF NUP188 ATM METTL25 SETD3 GTF3C3 XPOT NAA16	1.08e-06	333	87	10	gudmap_dev gonad_e13.5_M_GermCell_Oct_k1_1000
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_1000	BLM NCAPD3 BRDT CENPF PPP1R12B RABGAP1L RRAGB NUP188 ATM HERC1 METTL25 SETD3 DNAH8 NMD3 NAA16	1.10e-06	820	87	15	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_1000
CoexpressionAtlas	dev gonad_e11.5_F_PrimGermCell_Oct_k-means-cluster#3_top-relative-expression-ranked_1000	KIF20A BLM NCAPD3 CENPF RRAGB NUP188 PRC1 DDX39A GTF3C3 XPOT NMD3	2.97e-06	463	87	11	gudmap_dev gonad_e11.5_F_PrimGermCell_Oct_k3_1000
CoexpressionAtlas	dev gonad_e13.5_M_GermCell_Oct_top-relative-expression-ranked_1000	BLM ATP6V1B2 NCAPD3 BRDT CENPF C10orf53 NUP188 ATM HERC1 METTL25 SETD3 GTF3C3 XPOT NAA16	5.03e-06	810	87	14	gudmap_dev gonad_e13.5_M_GermCell_Oct_1000
CoexpressionAtlas	dev gonad_e11.5_M_PrimGermCell_Oct_k-means-cluster#2_top-relative-expression-ranked_1000	BLM NCAPD3 CENPF RRAGB NUP188 PRC1 DDX39A NMD3	1.09e-05	258	87	8	gudmap_dev gonad_e11.5_M_PrimGermCell_Oct_k2_1000
CoexpressionAtlas	dev gonad_e12.5_M_GermCellTestis_Oct_k-means-cluster#2_top-relative-expression-ranked_1000	BLM CENPF RRAGB NUP188 ATM METTL25 NMD3 NAA16	1.36e-05	266	87	8	gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_k2_1000
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_k-means-cluster#2_top-relative-expression-ranked_1000	BLM CENPF RRAGB NUP188 ATM METTL25 SETD3 NAA16	1.17e-04	361	87	8	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_k2_1000
ToppCell	ICU-NoSEP-Lymphocyte-T_NK-NK_CD56bright\|ICU-NoSEP / Disease, Lineage and Cell Type	ORC4 NCKAP1 STK17A MED14 CARNMT1 ZNF236	1.49e-06	167	94	6	f4f188a8efca8cdd0ecfb857fe4538c10847eadd
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF20A BLM NF1 CENPF PRC1 SPATA2	1.89e-06	174	94	6	72df66319f6efbd88ecf439013d97409fbf3cb52
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF20A BLM NF1 CENPF PRC1 SPATA2	1.89e-06	174	94	6	c6087fd0e036ec7f40f0f8f17d1f6ce13ddb5235
ToppCell	BAL-Mild-cDC_4\|Mild / Compartment, Disease Groups and Clusters	SEC16B PTCD1 LRRK2 FANCM TRUB2 NAA16	2.22e-06	179	94	6	68511e87b12b8253de7771e5ccfc5869248b8450
ToppCell	RV-08._Macrophage\|World / Chamber and Cluster_Paper	PDE4B CHST15 CENPF DOCK8 FPR3 SPIDR	3.33e-06	192	94	6	a1b5dc5beb97a23729b97b54fb4574d10d8fbfb3
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW19-Stem_cells-Stem_cells\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	KIF20A TGFBR2 NCAPD3 MYLK CENPF PRC1	3.97e-06	198	94	6	50f236ab7ef6f00721f6cd714e3eee183077beeb
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KIF20A BLM CENPF DOCK8 FPR3 FES	3.97e-06	198	94	6	732a43061d75bc5e1cf23f5056b72cd10c926668
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW19-Stem_cells\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	KIF20A TGFBR2 NCAPD3 MYLK CENPF PRC1	3.97e-06	198	94	6	dc0c6189ff9dd76675f63acf1cbc7dda60e75f3f
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	NF1 PPP1R12B RABGAP1L SPIDR HERC1 MED13L	4.09e-06	199	94	6	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF20A NCAPD3 CENPF SERAC1 PRC1	2.48e-05	163	94	5	3efbbdc9cb2613bb76d8c2f07cd4ec1a2c51a622
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NCAPD3 BRDT CENPF PRC1 TEKT5	2.56e-05	164	94	5	1642a67c66eeb77a218e7814e3cfe517d9822955
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NCAPD3 BRDT CENPF PRC1 TEKT5	2.56e-05	164	94	5	25758fb8112baf296264122d5d4121f1ebb3d0fa
ToppCell	356C-Epithelial_cells-Epithelial-D_(AT2)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	PTCD1 ANKRD1 CFTR TOM1L1 PTPRU	2.71e-05	166	94	5	2e4cb4056e6b0c43290a5588ff525f5f05b8beee
ToppCell	356C-Epithelial_cells-Epithelial-D_(AT2)\|356C / Donor, Lineage, Cell class and subclass (all cells)	PTCD1 ANKRD1 CFTR TOM1L1 PTPRU	2.71e-05	166	94	5	eb8d972326a734549675307e411fc795af66da70
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KIF20A BLM NCAPD3 CENPF PRC1	2.79e-05	167	94	5	bc132b51dec4e8f1cd2b2cd89f83641976e09292
ToppCell	PND14-Immune-Immune_Myeloid-Dendritic\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF20A CENPF SERAC1 RRAGB PRC1	2.87e-05	168	94	5	9b8a74abb83c64f0b5829dcb4275f722c82b45dc
ToppCell	PND14-Immune-Immune_Myeloid-Dendritic-cDC1\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF20A CENPF SERAC1 RRAGB PRC1	2.87e-05	168	94	5	4b152b8d0f4a66faf664dfacb7914b18d60ce64a
ToppCell	PND14-Immune-Immune_Myeloid-Dendritic-cDC1-cDC1_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF20A CENPF SERAC1 RRAGB PRC1	2.87e-05	168	94	5	c3169ad8f4130ef18777ed86770bb722ffb5db85
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_progenitors-Cycling_pre-Myeloid-2\|lymph-node_spleen / Manually curated celltypes from each tissue	KIF20A CENPF CES1 FES PRC1	3.30e-05	173	94	5	783b8fa08b9d8f597f251793eae164151662f1f9
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KIF20A BLM NCAPD3 CENPF PRC1	3.39e-05	174	94	5	84da9faff088d05233183b425385beb054c92d1b
ToppCell	facs-Marrow-KLS-18m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF20A SEC16B PRC1 DNAH8 VCAM1	3.39e-05	174	94	5	9d5dcd46cf346c381dea68ada6665f7fb68114a3
ToppCell	facs-Marrow-KLS-18m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF20A SEC16B PRC1 DNAH8 VCAM1	3.39e-05	174	94	5	53cec5c666c45278a71c21dd9c62a052a97e0fdf
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KIF20A BLM NCAPD3 CENPF PRC1	3.39e-05	174	94	5	dbb4e1a6c3319ce40f81bfd2d1745a88a2cc412e
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_G2M\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NCAPD3 CENPF WRN RRAGB PRC1	3.39e-05	174	94	5	41eb0a214a8b4015a26311f77061c8147144f0e7
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYLK CENPF ARHGEF9 FHDC1 PRC1	3.39e-05	174	94	5	7fb7bdf62563f2102fb38618b503eb2817b6594f
ToppCell	390C-Lymphocytic-ILC-ILC-1\|390C / Donor, Lineage, Cell class and subclass (all cells)	PDE6B TOM1L1 TTC21B MED14 METTL25	3.89e-05	179	94	5	e7045e27f0eb88f552b31c04b56d78e5ccd7a36c
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KIF20A BLM NCAPD3 CENPF PRC1	3.99e-05	180	94	5	f8a15c13d85c1bbbf86ce49bb6f86c368ddf22df
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating-Alveolar_macrophage_proliferating_L.1.0.7.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KIF20A BLM NCAPD3 CENPF PRC1	4.10e-05	181	94	5	73b1b59810f60e3e39ca1d5073a5a0d4f5377e6e
ToppCell	droplet-Lung-1m-Hematologic-lymphocytic-Proliferating_T_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KIF20A NCAPD3 CENPF PRC1 FANCM	4.54e-05	185	94	5	0e0f043ad6d2a62cd47ce39911ad81feab4a4d7e
ToppCell	droplet-Lung-1m-Hematologic-lymphocytic-Proliferating_T_cell-proliferating_T\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KIF20A NCAPD3 CENPF PRC1 FANCM	4.54e-05	185	94	5	89b85ce8026dc80c1bd9f76dfe16401c173b7946
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN14 TBC1D4 DOCK8 LRRK2 VCAM1	4.66e-05	186	94	5	5c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCell	droplet-Marrow-nan-24m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF20A CENPF TOM1L1 FHDC1 PRC1	4.78e-05	187	94	5	99724aa3dbdcb073ea3bfe80cc825ecae5495db8
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	NF1 BTAF1 HERC1 MED13L ZBTB11	4.91e-05	188	94	5	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	NS-critical-d_0-4-Lymphoid-NKT-proliferating\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	KIF20A BLM NCAPD3 CENPF PRC1	5.03e-05	189	94	5	d6bd46abb072b13a6b72f1ca25d19f218cceb1ff
ToppCell	COVID-19-Heart-Macrophage\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE4B CHST15 DOCK8 FPR3 APBA1	5.03e-05	189	94	5	2586f4088721c5debec86c2b211b739fd33713eb
ToppCell	human_hepatoblastoma-Inflammatory_Monocytes\|World / Sample and Cell Type and Tumor Cluster (all cells)	PDE4B DOCK8 FPR3 LRRK2 APBA1	5.29e-05	191	94	5	3b59bfc6c106ae8a3fbcd4a74bd128c485724921
ToppCell	3'_v3-bone_marrow-Lymphocytic_T_CD4/8-lo-Cycling_T\|bone_marrow / Manually curated celltypes from each tissue	KIF20A NCAPD3 CENPF PRC1 DDX39A	5.29e-05	191	94	5	210a0f1a71df2508cbfc73d6868a2122338b9a1c
ToppCell	droplet-Marrow-BM-30m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCAPD3 CENPF TOM1L1 FHDC1 PRC1	5.29e-05	191	94	5	08be56a4055a73c920d345fd3b2052a5ccb675d8
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PDE4B CENPF UNC45B PRC1 DNAH8	5.42e-05	192	94	5	1a3f24607cb49aa610c183f4c2b7d735f484a3a4
ToppCell	facs-Aorta-Heart-3m\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFBR2 TBC1D4 CHST15 OSBPL9 PTPRU	5.42e-05	192	94	5	1ccc47792edf9ee23501c8e2165d11271636b66a
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PDE4B CENPF UNC45B PRC1 DNAH8	5.42e-05	192	94	5	c8dcd75d695d09adff083af8d5a64cf15fe027d4
ToppCell	P07-Endothelial-proliferative_endothelial_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	KIF20A NCAPD3 CENPF PRC1 DDX39A	5.56e-05	193	94	5	1e95ef29357969ee385b4717c0b5a497390ac260
ToppCell	droplet-Tongue-nan-24m-Epithelial-proliferating\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF20A NCAPD3 PDE4B CENPF PRC1	5.56e-05	193	94	5	f20b90e3f3f5c9a1ae51c5ebe6d3adb954a142f2
ToppCell	P07-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	KIF20A NCAPD3 CENPF PRC1 DDX39A	5.56e-05	193	94	5	0f21fb8b35f89f4c1c8109d1a4d3d08a452f9edd
ToppCell	P03-Endothelial-proliferative_endothelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	KIF20A NCAPD3 CENPF PRC1 DDX39A	5.69e-05	194	94	5	22bcfb0f3f73608feb22c0847ab4d34f87aeede0
ToppCell	P03-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	KIF20A NCAPD3 CENPF PRC1 DDX39A	5.69e-05	194	94	5	5e56ce9b9fe0721be3a9e6efe1422599bb867721
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	KIF20A BLM NCAPD3 CENPF PRC1	5.69e-05	194	94	5	f9070035553bc68106a9e0bdf4b507715a138aba
ToppCell	human_hepatoblastoma-Inflammatory_Monocytes\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	PDE4B DOCK8 FPR3 LRRK2 APBA1	5.83e-05	195	94	5	ba7f85e5307d96ac5ad7c952f8d094db9ca1790c
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	KIF20A BLM NCAPD3 CENPF PRC1	5.98e-05	196	94	5	1964c5003a0cb84539850a7cfe3bbb0e23a61d2d
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	KIF20A BLM NCAPD3 CENPF PRC1	6.12e-05	197	94	5	84ed777cdba569200a3ef1654d8a12f17fcfb7f1
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	GLOD5 BTAF1 ATM HERC1 DDX39B	6.12e-05	197	94	5	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	BAL-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	KIF20A BLM NCAPD3 CENPF PRC1	6.12e-05	197	94	5	d7a9296092153cf66426911fecd810f0c1ef978e
ToppCell	BAL-Mild-Lymphocyte-T/NK-Other_T\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	KIF20A BLM NCAPD3 CENPF PRC1	6.12e-05	197	94	5	dcff23240bb7cb652d7426b29355aa74442ef6fc
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alv_dividing\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KIF20A BLM PDE4B CENPF MYO7B	6.12e-05	197	94	5	d669d90c3f9e98b41bcbc49dbdc5698e0b42597c
ToppCell	BAL-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	KIF20A BLM NCAPD3 CENPF PRC1	6.12e-05	197	94	5	f34b1e34f1f0694564031077172c890b233ce8b7
ToppCell	18-Airway-Mesenchymal-Mesenchyme_RSPO2+\|Airway / Age, Tissue, Lineage and Cell class	KIF20A MYLK CENPF PRC1 VCAM1	6.42e-05	199	94	5	7ac35e8f45dcdc702422dabd8f3e4d03e2bf61af
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma\|TCGA-Bladder / Sample_Type by Project: Shred V9	KIF20A BLM CENPF PRC1 DDX39A	6.42e-05	199	94	5	8ee3dbc0a92de5f3865e5484970ae2aab7d1a956
ToppCell	TCGA-Bladder-Primary_Tumor\|TCGA-Bladder / Sample_Type by Project: Shred V9	KIF20A BLM CENPF PRC1 DDX39A	6.42e-05	199	94	5	c403e28def2e14f5931cd73b4fb9a4078c0439f8
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DOCK8 ITSN2 BTAF1 ATM MED13L	6.58e-05	200	94	5	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	Sepsis-ICU-NoSEP-Lymphocyte-T/NK-NK_CD56bright\|ICU-NoSEP / Disease, condition lineage and cell class	ORC4 NCKAP1 STK17A MED14 ZNF236	6.58e-05	200	94	5	c2df917900872453ea17a39928e39d071a6d3339
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-7\|TCGA-Brain / Sample_Type by Project: Shred V9	OR7E24 CENPF LRRK2 FANCM	1.97e-04	136	94	4	d94f0fbeb7b80d4cf0687d1924ebf8f9dd07358c
ToppCell	367C-Lymphocytic-ILC-ILC-2\|ILC / Donor, Lineage, Cell class and subclass (all cells)	TGFBR2 ATM ANO10	2.14e-04	55	94	3	7916216b3a24f9c6b966aa5392fc2bc43b3d2c4c
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SEC16B PTCD1 LRRK2 FANCM	2.80e-04	149	94	4	a85a051e0d82430160967e72fa04b55f43e84513
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SEC16B PTCD1 LRRK2 FANCM	2.87e-04	150	94	4	7a381f5ae94eba5eb60dcbf83416b4eb18c279ea
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-6\|TCGA-Kidney / Sample_Type by Project: Shred V9	KIF20A BLM DRP2 CENPF	3.33e-04	156	94	4	d249747c7108a0edfc72d24c09b0b0e4ed662b40
ToppCell	LPS-antiTNF-Endothelial-Endothelial-FOXM1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KIF20A NCAPD3 CENPF PRC1	3.93e-04	163	94	4	5285318c52aa31c9b22dc2ffff078e32e408604d
ToppCell	facs-Marrow-T-cells-24m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCAPD3 CENPF PRC1 VCAM1	4.02e-04	164	94	4	2a230ea066decb798a0e6f2b96c7608c8e608031
ToppCell	facs-Marrow-T-cells-24m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCAPD3 CENPF PRC1 VCAM1	4.02e-04	164	94	4	d02d39edd0bfef5a53b814ec6d5f026d41253218
ToppCell	control-Epithelial-Ionocyte\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	TBC1D4 CHST15 PPP1R12B CFTR	4.11e-04	165	94	4	5cfba9a46bd8ceeca74a6493057b4d38af6b06fe
ToppCell	Dividing_Macrophages-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	KIF20A CENPF MYO7B PRC1	4.21e-04	166	94	4	c503036f3c19ef186e1e62c9643c49dea3827f51
ToppCell	10x5'-Liver-Hematopoietic_progenitors\|Liver / Manually curated celltypes from each tissue	KIF20A CENPF PRC1 FANCM	4.21e-04	166	94	4	ae967570248cf86ca3ddf55e33bcbb3e4e3684bc
ToppCell	10x5'-Liver-Hematopoietic_progenitors-Cycling_pre-Myeloid-2\|Liver / Manually curated celltypes from each tissue	KIF20A CENPF PRC1 FANCM	4.21e-04	166	94	4	a176e87aa6eec81d1fb79a028f759182d11b567d
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KIF20A BLM CENPF PRC1	4.21e-04	166	94	4	2642544070564debe2deb2938d2c33997bf5ef02
ToppCell	NS-control-d_0-4-Epithelial-Ionocyte\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TBC1D4 CHST15 PPP1R12B CFTR	4.21e-04	166	94	4	6d9fb239f69ba519844f593c00d515e1aac4ff50
ToppCell	PND14-Immune-Immune_Myeloid-DC-cDC2-cDC2_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF20A BLM CENPF PRC1	4.40e-04	168	94	4	b7cd33f5da4f37b9384fc3bd3ca01fbc790accfc
ToppCell	control-Epithelial-Ionocyte\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	TBC1D4 CHST15 PPP1R12B CFTR	4.40e-04	168	94	4	327b02f19f4a8607c033203824fdc60a1254331f
ToppCell	PND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF20A CENPF WRN PRC1	4.40e-04	168	94	4	52fd65024af8683db11d931f7563cbe8eb815d1c
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TBC1D4 CENPF RRAGB RIMS1	4.50e-04	169	94	4	c8691c4f707d46b2865fe46eabe24ea4d03c7b43
ToppCell	343B-Lymphocytic-NK_cells-Proliferating_NK_cell\|343B / Donor, Lineage, Cell class and subclass (all cells)	KIF20A NCAPD3 CENPF PRC1	4.50e-04	169	94	4	02fa66a91b8bd2bf971aec4f5ec58318b5bfdf14
ToppCell	PND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYLK ANKRD1 RRAGB RIMS1	4.50e-04	169	94	4	88aa2246ede582c2e11de63228d76f520889ecb3
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-FOXM1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KIF20A NCAPD3 CENPF PRC1	4.50e-04	169	94	4	e0607af8ae8609d43e26ff2a2cab92650bfcd5b7
ToppCell	PND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYLK ANKRD1 RRAGB RIMS1	4.50e-04	169	94	4	a6a5b00912b653fad2ca7f096deaf35c9ef85e5b
ToppCell	PND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYLK ANKRD1 RRAGB RIMS1	4.50e-04	169	94	4	42a9b8c77d2a4d68b01e4db38f8a1af53c9c814f
ToppCell	facs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF20A NCAPD3 ANO10 PTPRU	4.71e-04	171	94	4	913bae728b5e653771a27c79a309eb023699f1d0
ToppCell	facs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF20A NCAPD3 ANO10 PTPRU	4.71e-04	171	94	4	f28b2336057e353b96a6ff4581ec9fd0ca0789d9
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	ANKRD1 BTAF1 ATM HERC1	4.71e-04	171	94	4	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(15)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	KIF20A CENPF PRC1 DDX39A	4.81e-04	172	94	4	7f3d0ef18f5df1ed80498d435b0378ca398c0b88
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_G2M\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF20A NCAPD3 CENPF PRC1	4.81e-04	172	94	4	c06ca5d075937747952ed915c9db39a9f62072f9
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF20A ERICH3 CENPF PRC1	4.81e-04	172	94	4	dd9ba79e1542fe9fa2c319077d83dd3fc0158f46
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-epithelial_cell_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CENPF CFTR PRC1 DNAH8	4.92e-04	173	94	4	a5172dee859bf6c2eed46c48bd64dfef0ff9f28f
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-Lgr5-_amplifying_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CENPF CFTR PRC1 DNAH8	4.92e-04	173	94	4	639b5b0b33ce5aa0bc26363c059717012ddc14c0
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BLM BRDT PPP1R12B DNAH8	4.92e-04	173	94	4	8bffd512a4e561e23cc04478e2ca6fd5d3771fe4
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BLM BRDT PPP1R12B DNAH8	4.92e-04	173	94	4	3e3c61468e703330788a10d850ef41a85680f86d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF20A CENPF PRAMEF8 PRC1	4.92e-04	173	94	4	f38bf7584e08d15a6e2c116b7c3551ba475a5e14
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIF20A BLM CENPF PRC1	5.03e-04	174	94	4	c26eac176e9b0cba385630fdc60e0314a4e4caac
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_progenitors\|lymph-node_spleen / Manually curated celltypes from each tissue	KIF20A CENPF CES1 PRC1	5.03e-04	174	94	4	029394e107bf7ad58056d2216070aa2e964fff12
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF20A CENPF RIMS1 PRC1	5.03e-04	174	94	4	7b2f35add804981c7d588a996bdbca6ec11a1ca5
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4/8-lo-Cycling_T\|GI_small-bowel / Manually curated celltypes from each tissue	KIF20A SEC16B CENPF PRC1	5.03e-04	174	94	4	e4c8da80eca07e4396f57dad212f76c2eca4c1bd
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AMFR TBC1D4 DOCK8 CFTR	5.03e-04	174	94	4	5f4436863a40f8bca46e2989bca66c02b6be88d4
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF20A DRP2 CENPF PRC1	5.13e-04	175	94	4	d43ae33a6256606ce848247cad32d74f21b38988
Disease	carbohydrate sulfotransferase 15 measurement	CHST15 FPR3	9.35e-05	5	91	2	EFO_0008066
Disease	Werner syndrome (implicated_via_orthology)	BLM WRN	9.35e-05	5	91	2	DOID:5688 (implicated_via_orthology)
Disease	Neurodevelopmental Disorders	NCKAP1 DOCK8 RIMS1 MED13L	2.00e-04	93	91	4	C1535926
Disease	Hypercholesterolemia	MYLK CES1 VCAM1	2.39e-04	39	91	3	C0020443
Disease	Lymphoma	BLM DOCK8 ATM	2.58e-04	40	91	3	C0024299
Disease	Gastric Adenocarcinoma	TGFBR2 BRDT ATM	3.67e-04	45	91	3	C0278701
Disease	Familial thoracic aortic aneurysm and aortic dissection	TGFBR2 MYLK	4.17e-04	10	91	2	cv:C4707243
Disease	Malignant neoplasm of breast	AMFR PTPN14 NF1 CENPF UNC45B PPP1R12B ITSN2 MED14 ATM PRC1 THOC5	4.67e-04	1074	91	11	C0006142
Disease	Intellectual Disability	NF1 DOCK8 CACNA1G SERAC1 MED13L ZBTB11 GTF3C3	4.73e-04	447	91	7	C3714756
Disease	senile cataract (is_implicated_in)	WRN ATM	5.08e-04	11	91	2	DOID:9669 (is_implicated_in)
Disease	Ashkenazi Jewish disorders	BLM CFTR	5.08e-04	11	91	2	cv:CN118946
Disease	leukemia	BLM NF1 ATM	6.63e-04	55	91	3	C0023418
Disease	Mental Retardation, Psychosocial	NF1 DOCK8 CACNA1G MED13L	9.18e-04	139	91	4	C0025363
Disease	Profound Mental Retardation	NF1 DOCK8 CACNA1G MED13L	9.18e-04	139	91	4	C0020796
Disease	Mental deficiency	NF1 DOCK8 CACNA1G MED13L	9.18e-04	139	91	4	C0917816
Disease	Colorectal Carcinoma	TGFBR2 NF1 CFTR WRN PTPRU FBXL2 DNAH8 MFN1	1.48e-03	702	91	8	C0009402
Disease	Chronic myeloproliferative disorder	ORC4 CENPF	1.55e-03	19	91	2	C1292778
Disease	Manic	PDE4B RIMS1 DNAH8	1.83e-03	78	91	3	C0338831
Disease	pulmonary hypertension (biomarker_via_orthology)	TGFBR2 VCAM1 MFN1	1.96e-03	80	91	3	DOID:6432 (biomarker_via_orthology)
Disease	Leukemia, Myelocytic, Acute	BLM PDE4B NF1 FANCM	2.05e-03	173	91	4	C0023467
Disease	Seckel syndrome	ORC4 CENPF	2.09e-03	22	91	2	C0265202
Disease	attempted suicide	MYO7B RIMS1 FHDC1 DNAH8	2.27e-03	178	91	4	EFO_0004321
Disease	Immunologic Deficiency Syndromes	BLM ATM	2.28e-03	23	91	2	C0021051
Disease	Glioma	NF1 MYLK ATM	2.49e-03	87	91	3	C0017638
Disease	myeloproliferative disorder	LINC01565 ATM	2.69e-03	25	91	2	EFO_0004251
Disease	response to interferon	RIMS1 CMAS	2.69e-03	25	91	2	EFO_0007859
Disease	nevus count, cutaneous melanoma	DOCK8 ATM MED13L	2.83e-03	91	91	3	EFO_0000389, EFO_0004632
Disease	Acute monocytic leukemia	BLM FANCM	2.91e-03	26	91	2	C0023465
Disease	Hereditary Nonpolyposis Colorectal Neoplasms	TGFBR2 ATM	2.91e-03	26	91	2	C0009405

Protein segments in the cluster

Peptide	Gene	Start	Entry
LVHCETDNKIMLELA	TTC21B	911	Q7Z4L5
RECLAQAIFHKVLDM	ERICH3	66	Q5RHP9
VMVHCLRQKTEEELL	CES1	281	P23141
EHRIEAMLECQQFLV	CFTR	1401	P13569
EILLTIVNDCIHMFE	CARNMT1	121	Q8N4J0
EQLRHCSEILKEMLA	BRDT	271	Q58F21
CLEGHLAIVEKLMEA	ANKRD1	161	Q15327
KHFILDECDKMLEQL	DDX39B	191	Q13838
HFVLDECDKMLEQLD	DDX39A	191	O00148
LIIFNDCELDKAVRM	ALDH1L2	701	Q3SY69
MKEALHQIVVRCSEL	LINC01565	1	O15544
FLFDHQMVLCKKDLI	ARHGEF9	341	O43307
MEIKHLLFLVAAACL	CRISP1	1	P54107
LMVHVIEATELKACK	ITSN2	1571	Q9NZM3
MVESIKHCIVLLQIA	OSBPL9	166	Q96SU4
HMERCLHFLVEELKV	MFN1	256	Q8IWA4
MAECQFIIKHELENL	ANO10	121	Q9NW15
ICLIIAMKHLNDIYE	ORC4	326	O43929
AIKELMSCEELHSIL	FHDC1	281	Q9C0D6
HELEKMDLEECILIT	FBXL2	286	Q9UKC9
IVHLDLKPENIMCVN	MYLK	1581	Q15746
IHNLLERCLMDKNFV	MED13L	126	Q71F56
LEEMIQHLKACDVPI	GLOD5	111	A6NK44
DIIKDLEDCLMVGLH	METTL25	371	Q8N6Q8
HLQSMFERICVIVEK	FANCM	1886	Q8IYD8
FLCKLVHVMIDINLF	FPR3	96	P25089
CLDEHLMQFKFLGIL	HERC1	4571	Q15751
LLQEEHCDIFMNLTK	PDE4B	486	Q07343
MVLYHVKCDRDEIQL	PDE6B	451	P35913
EHIEMYEKQICDKLL	NAA16	211	Q6N069
ISDLCEMHIDTVLKE	DNAH8	711	Q96JB1
LIDCVHFLREVMVKE	LRRK2	2386	Q5S007
LEAQDHTIRILMCQK	GOLGA6L7	86	A0A1B0GV03
MEFKDHVCELLNTID	NCKAP1	101	Q9Y2A7
LLHMPEEQAFCVLVK	RABGAP1L	631	Q5R372
CVHIMKLELFPDQAT	MED14	1316	O60244
VLEMIRCHNLVDVFF	PTPRU	1396	Q92729
DHKCFMGVAQILLEE	RIMS1	1631	Q86UR5
KMEKCFLELLEFNIH	CCNYL3	156	P0C7X3
VKENLIELMADICHQ	ATM	341	Q13315
QLIHVMEHICKLIDT	BLM	371	P54132
EMALEHELKLSIICL	DOCK8	766	Q8NF50
CQLKSMLDIVEHDLL	BTAF1	1651	O14981
KMFDHVVLVIIFLNC	CACNA1G	1276	O43497
LHLQEVQLMTKIEAC	CENPF	1811	P49454
KMICHVFESEDAQLI	APBA1	586	Q02410
AEMQELAIQLHKRCE	ANKS3	506	Q6ZW76
HSIIEVLNMVELDCI	PRAMEF8	191	Q5VWM4
VSLCLEDIMEKLRHA	DRP2	926	Q13474
SLQDLHEEMACILKE	FES	211	P07332
HEEMACILKEILQEY	FES	216	P07332
AYQCEKHVLVILTDM	ATP6V1B2	286	P21281
VEMFCLEAIVKHSEI	SERAC1	271	Q96JX3
LVCQAKLHIDDMEFE	VCAM1	481	P19320
HKEIQLTLSLIDMCV	TOM1L1	66	O75674
EFAEHICLLMEKVNN	CMAS	416	Q8NFW8
LHNLIMLQLTCFKDV	OR7E24	176	Q6IFN5
SIKRQIILCMEALDH	PRC1	176	O43663
LMIYCLEHNEKVEVP	PTPN14	1136	Q15678
RVFCMTEEELKEHLL	SETD3	386	Q86TU7
TRKLMEFSEHCAIIL	TGFBR2	206	P37173
QLLVMTKCRLEHELA	TEKT5	441	Q96M29
CLMSLDITEHELQIL	WRN	391	Q14191
LLAVNMVFCEAKIIH	OR8S1	161	Q8NH09
CRMEIIHEIAVLELA	STK17A	101	Q9UEE5
IDITVKLMVCLVHLN	GTF3C3	386	Q9Y5Q9
VFLHLMVQLCKDRFE	AMFR	156	Q9UKV5
HEKVTEALQLFENCM	CHST15	416	Q7LFX5
HKFLVQEIMFDRCLD	NCAPD3	441	P42695
MVNEEVIFHCNIKDL	C10orf53	56	Q8N6V4
HSIIEVLNMVELDCI	PRAMEF7	191	Q5VXH5
ELLHEFECNVEMLKQ	UHRF1BP1L	391	A0JNW5
CNMVLHKEVQERFLA	UNC45B	786	Q8IWX7
LFLAKVECEQMLEIH	SPATA2	166	Q9UM82
FMSEVLEICESVHKL	ZBTB11	296	O95625
NKLCETVMAQILEHL	VPS35L	861	Q7Z3J2
VKILELHEECAMQVA	SPIDR	301	Q14159
KLQLEMHLRDEICNE	KIF20A	581	O95235
KIFCLVHKMDLVQED	RRAGA	121	Q7L523
IRAMIEVINHKCDLV	TPP2	311	P29144
ETMLVKQLLPEICHF	NF1	106	P21359
LILVEGMDIESLHKC	NUP188	271	Q5SRE5
VDRLCVLHVEEAMVF	SCART1	156	Q4G0T1
AKIFCLVHKMDLVQE	RRAGB	181	Q5VZM2
LIDDCMEKFSLHEQQ	TBC1D4	221	O60343
LIREDVHKVDIMTFC	SEC16B	331	Q96JE7
EDLRQMCHKAVVELF	TRIM51G	231	A0A3B3IT33
LKTCLLEDTLHVVDM	TTLL9	356	Q3SXZ7
TFLHRMIICLEEEVL	XPOT	706	O43592
HIMLHEKEENLICSE	ZNF236	111	Q9UL36
FLLEVQCMHETQKEL	TRUB2	221	O95900
EVMHLQKEITKCLEF	THOC5	136	Q13769
ADLRMCLDVFKEIIH	PTCD1	261	O75127
LRCLMDLLHEELKEQ	USP33	276	Q8TEY7
MKLLEVQHQELRDCL	MYO7B	356	Q6PIF6
HQACIDENLDMVKFL	PPP1R12B	96	O60237
SLCHPKQLEEFIVME	NMD3	306	Q96D46