Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	inositol 1,4,5-trisphosphate-gated calcium channel activity	ITPR1 ITPR2 ITPR3	1.54e-07	3	108	3	GO:0005220
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	ITPR1 ITPR2 TPCN1 ITPR3	2.34e-06	18	108	4	GO:0015278
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	ITPR1 ITPR2 TPCN1 ITPR3	2.28e-05	31	108	4	GO:0099604
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	ITPR1 ITPR2 TPCN1 ITPR3	2.93e-05	33	108	4	GO:0005217
GeneOntologyMolecularFunction	inositol 1,4,5 trisphosphate binding	ITPR1 ITPR2 ITPR3	5.36e-05	14	108	3	GO:0070679
GeneOntologyMolecularFunction	calcium channel activity	ITPR1 ITPR2 TPCN1 ITPR3 CACNG6 CACNA1G	7.22e-05	129	108	6	GO:0005262
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	GRIK4 ITPR1 ITPR2 TPCN1 ITPR3 HTR3D	1.14e-04	140	108	6	GO:0099094
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	ITPR1 ITPR2 TPCN1 ITPR3 CACNG6 CACNA1G	1.72e-04	151	108	6	GO:0015085
GeneOntologyMolecularFunction	gated channel activity	GRIK4 ITPR1 ITPR2 TPCN1 ITPR3 CACNG6 HTR3D CACNA1G	4.65e-04	334	108	8	GO:0022836
GeneOntologyMolecularFunction	monoatomic cation channel activity	GRIK4 ITPR1 ITPR2 TPCN1 ITPR3 CACNG6 HTR3D CACNA1G	5.54e-04	343	108	8	GO:0005261
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	GRIK4 ITPR1 ITPR2 TPCN1 ITPR3 HTR3D	6.38e-04	193	108	6	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	GRIK4 ITPR1 ITPR2 TPCN1 ITPR3 HTR3D	7.10e-04	197	108	6	GO:0022834
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	GRIK4 NDUFA2 ATP13A2 ITPR1 ITPR2 TPCN1 ITPR3 CACNG6 HTR3D CACNA1G SLC4A4	9.39e-04	664	108	11	GO:0008324
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	GRIK4 NDUFA2 ATP13A2 SLC4A3 ITPR1 ITPR2 TPCN1 ITPR3 CACNG6 HTR3D CACNA1G SLC4A4	1.20e-03	793	108	12	GO:0015075
GeneOntologyMolecularFunction	syntaxin binding	STXBP5 TPCN1 VPS52 TMED10	1.28e-03	87	108	4	GO:0019905
GeneOntologyMolecularFunction	protein transporter activity	PEX1 AP4M1 TMED10	1.52e-03	42	108	3	GO:0140318
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	IQSEC2 RIN1 ARHGEF40 RAPGEF3 SBF2 WDR41	1.61e-03	231	108	6	GO:0005085
GeneOntologyMolecularFunction	phosphatidylinositol binding	ATP13A2 ITPR1 ITPR2 TPCN1 ITPR3 SNX6 SBF2	1.66e-03	316	108	7	GO:0035091
GeneOntologyCellularComponent	platelet dense tubular network membrane	ITPR1 ITPR2 ITPR3	1.13e-05	9	109	3	GO:0031095
GeneOntologyCellularComponent	platelet dense tubular network	ITPR1 ITPR2 ITPR3	2.21e-05	11	109	3	GO:0031094
GeneOntologyCellularComponent	RNA polymerase complex	ERCC2 POLA1 ZNFX1 TAF6L TAF7L TAF4B	3.77e-05	119	109	6	GO:0030880
GeneOntologyCellularComponent	transferase complex, transferring phosphorus-containing groups	ERCC2 NEK10 POLA1 ZNFX1 SOCS7 TAF6L TAF7L WDR41 TAF4B	6.55e-05	335	109	9	GO:0061695
GeneOntologyCellularComponent	transcription factor TFIID complex	ERCC2 TAF6L TAF7L TAF4B	1.05e-04	47	109	4	GO:0005669
GeneOntologyCellularComponent	nuclear DNA-directed RNA polymerase complex	ERCC2 POLA1 TAF6L TAF7L TAF4B	3.15e-04	113	109	5	GO:0055029
GeneOntologyCellularComponent	DNA-directed RNA polymerase complex	ERCC2 POLA1 TAF6L TAF7L TAF4B	3.56e-04	116	109	5	GO:0000428
GeneOntologyCellularComponent	90S preribosome	UTP6 NOL6 NOC4L	4.57e-04	29	109	3	GO:0030686
GeneOntologyCellularComponent	transferase complex	ERCC2 NEK10 POLA1 CUL9 ZNFX1 KEAP1 SOCS7 TAF6L FBXO6 TAF7L VHLL ASB4 WDR41 TAF4B	4.81e-04	963	109	14	GO:1990234
GeneOntologyCellularComponent	intracellular protein-containing complex	ERCC2 POLA1 CUL9 ZNFX1 KEAP1 ITPR1 TAF6L FBXO6 CNOT9 TAF7L VHLL ASB4 WDR41 TAF4B	5.27e-04	972	109	14	GO:0140535
GeneOntologyCellularComponent	RNA polymerase II, holoenzyme	ERCC2 TAF6L TAF7L TAF4B	1.22e-03	89	109	4	GO:0016591
HumanPheno	Cerebral calcification	ERCC2 PDGFRB PEX1 ZNFX1 ECM1 TINF2 PTCH2 SLC4A4	1.70e-05	151	40	8	HP:0002514
HumanPheno	Intracranial calcification	ERCC2 PDGFRB PEX1 ZNFX1 ECM1 TINF2 PTCH2 SLC4A4	1.70e-05	151	40	8	HP:0430048
HumanPheno	Abnormal temporal lobe morphology	ERCC2 PDGFRB PEX1 ZNFX1 ECM1 TINF2 PTCH2 SLC4A4	1.79e-05	152	40	8	HP:0034221
Domain	InsP3_rcpt-bd	ITPR1 ITPR2 ITPR3	1.73e-07	3	105	3	IPR000493
Domain	MIR	POMT2 ITPR1 ITPR2 ITPR3	1.93e-07	10	105	4	PF02815
Domain	MIR_motif	POMT2 ITPR1 ITPR2 ITPR3	1.93e-07	10	105	4	IPR016093
Domain	MIR	POMT2 ITPR1 ITPR2 ITPR3	1.93e-07	10	105	4	PS50919
Domain	MIR	POMT2 ITPR1 ITPR2 ITPR3	1.93e-07	10	105	4	SM00472
Domain	ARM-type_fold	NEK10 SARM1 INTS1 MROH5 CUL9 ZNFX1 ITPR1 ITPR2 CNOT9 NOC4L KPNA3	3.26e-06	339	105	11	IPR016024
Domain	RIH_assoc-dom	ITPR1 ITPR2 ITPR3	3.41e-06	6	105	3	IPR013662
Domain	Ins145_P3_rec	ITPR1 ITPR2 ITPR3	3.41e-06	6	105	3	PF08709
Domain	RIH_assoc	ITPR1 ITPR2 ITPR3	3.41e-06	6	105	3	PF08454
Domain	RIH_dom	ITPR1 ITPR2 ITPR3	3.41e-06	6	105	3	IPR000699
Domain	Ins145_P3_rcpt	ITPR1 ITPR2 ITPR3	3.41e-06	6	105	3	IPR014821
Domain	Ryanodine_recept-rel	ITPR1 ITPR2 ITPR3	3.41e-06	6	105	3	IPR015925
Domain	-	ITPR1 ITPR2 ITPR3	3.41e-06	6	105	3	1.25.10.30
Domain	RYDR_ITPR	ITPR1 ITPR2 ITPR3	3.41e-06	6	105	3	PF01365
Domain	ARM-like	NEK10 SARM1 MROH5 CUL9 CNOT9 TAF7L NOC4L KPNA3	1.43e-04	270	105	8	IPR011989
Domain	Ion_trans_dom	ITPR1 ITPR2 TPCN1 ITPR3 CACNA1G	4.61e-04	114	105	5	IPR005821
Domain	Ion_trans	ITPR1 ITPR2 TPCN1 ITPR3 CACNA1G	4.61e-04	114	105	5	PF00520
Domain	-	SLC4A3 SLC4A4	1.10e-03	9	105	2	3.40.1100.10
Domain	Band3_cytoplasmic_dom	SLC4A3 SLC4A4	1.10e-03	9	105	2	IPR013769
Domain	Band_3_cyto	SLC4A3 SLC4A4	1.10e-03	9	105	2	PF07565
Domain	PTrfase/Anion_transptr	SLC4A3 SLC4A4	1.37e-03	10	105	2	IPR016152
Domain	HCO3_transpt_euk	SLC4A3 SLC4A4	1.37e-03	10	105	2	IPR003020
Domain	HCO3_cotransp	SLC4A3 SLC4A4	1.37e-03	10	105	2	PF00955
Domain	HCO3_transpt_C	SLC4A3 SLC4A4	1.37e-03	10	105	2	IPR011531
Domain	-	NEK10 SARM1 MROH5 CUL9 CNOT9 KPNA3	1.60e-03	222	105	6	1.25.10.10
Domain	MRGPCRFAMILY	MRGPRF MRGPRX4	1.67e-03	11	105	2	IPR026234
Domain	Myotubularin-like_Pase_dom	MTMR11 SBF2	2.73e-03	14	105	2	IPR010569
Domain	PPASE_MYOTUBULARIN	MTMR11 SBF2	2.73e-03	14	105	2	PS51339
Domain	Myotubularin_fam	MTMR11 SBF2	2.73e-03	14	105	2	IPR030564
Domain	Myotub-related	MTMR11 SBF2	2.73e-03	14	105	2	PF06602
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY	ITPR1 ITPR2 ITPR3	2.25e-06	5	87	3	M49000
Pathway	KEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY	ITPR1 ITPR2 ITPR3	4.48e-06	6	87	3	M47960
Pathway	KEGG_MEDICUS_REFERENCE_BCR_PLCG_ITPR_SIGNALING_PATHWAY	ITPR1 ITPR2 ITPR3	1.86e-05	9	87	3	M47852
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR1 ITPR2 ITPR3	2.64e-05	10	87	3	M47661
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR1 ITPR2 ITPR3	3.61e-05	11	87	3	M49033
Pathway	REACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION	ITPR1 ITPR2 ITPR3	3.61e-05	11	87	3	M27466
Pathway	REACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION	ITPR1 ITPR2 ITPR3 RAPGEF3	4.26e-05	32	87	4	MM14983
Pathway	KEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR1 ITPR2 ITPR3	6.21e-05	13	87	3	M47656
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2 ITPR3	6.21e-05	13	87	3	M47696
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_SIGMAR1_TO_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2 ITPR3	6.21e-05	13	87	3	M47751
Pathway	REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS	ITPR1 ITPR2 ITPR3	6.21e-05	13	87	3	MM14553
Pathway	REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS	ITPR1 ITPR2 ITPR3	1.20e-04	16	87	3	M26945
Pathway	REACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION	ITPR1 ITPR2 ITPR3 RAPGEF3	1.27e-04	42	87	4	M791
Pathway	SIG_CHEMOTAXIS	ITPR1 ITPR2 ITPR3 LIMK1	1.66e-04	45	87	4	M5193
Pathway	REACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATION	ITPR1 ITPR2 ITPR3	2.05e-04	19	87	3	M27423
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2 ITPR3	2.05e-04	19	87	3	M47760
Pathway	KEGG_MEDICUS_REFERENCE_TCR_PLCG_ITPR_SIGNALING_PATHWAY	ITPR1 ITPR2 ITPR3	2.05e-04	19	87	3	M47733
Pathway	KEGG_GAP_JUNCTION	DRD1 PDGFRB ITPR1 ITPR2 ITPR3	2.32e-04	90	87	5	M4013
Pathway	KEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2 ITPR3	2.40e-04	20	87	3	M47688
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2 ITPR3	2.79e-04	21	87	3	M47689
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2 ITPR3	3.21e-04	22	87	3	M47690
Pathway	KEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2 ITPR3	3.21e-04	22	87	3	M47675
Pathway	KEGG_MEDICUS_REFERENCE_RTK_PLCG_ITPR_SIGNALING_PATHWAY	PDGFRB ITPR1 ITPR2 ITPR3	3.63e-04	55	87	4	M47952
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2 ITPR3	3.68e-04	23	87	3	M47676
Pathway	REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS	ITPR1 ITPR2 ITPR3	4.73e-04	25	87	3	MM14511
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	ITPR1 ITPR2 ITPR3 RAPGEF3	5.40e-04	61	87	4	MM15071
Pathway	REACTOME_CA2_PATHWAY	ITPR1 ITPR2 ITPR3 MOV10	5.75e-04	62	87	4	M27321
Pathway	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	ITPR1 ITPR2 ITPR3	5.97e-04	27	87	3	MM15053
Pathway	REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS	ITPR1 ITPR2 ITPR3	5.97e-04	27	87	3	M12123
Pathway	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	ITPR1 ITPR2 ITPR3	6.65e-04	28	87	3	M924
Pathway	KEGG_CALCIUM_SIGNALING_PATHWAY	DRD1 PDGFRB ITPR1 ITPR2 ITPR3 CACNA1G	8.07e-04	178	87	6	M2890
Pathway	KEGG_LONG_TERM_DEPRESSION	PLA2G3 ITPR1 ITPR2 ITPR3	9.10e-04	70	87	4	M8232
Pathway	KEGG_LONG_TERM_POTENTIATION	ITPR1 ITPR2 ITPR3 RAPGEF3	9.10e-04	70	87	4	M3115
Pathway	REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	ITPR1 ITPR2 ITPR3 RAPGEF3	1.01e-03	72	87	4	MM14631
Pathway	KEGG_BASAL_TRANSCRIPTION_FACTORS	TAF6L TAF7L TAF4B	1.29e-03	35	87	3	M4864
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	ITPR1 ITPR2 ITPR3 RAPGEF3	1.36e-03	78	87	4	M1921
Pathway	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	ITPR1 ITPR2 ITPR3	1.40e-03	36	87	3	M1315
Pathway	WP_VITAMIN_DSENSITIVE_CALCIUM_SIGNALING_IN_DEPRESSION	ITPR1 ITPR2 ITPR3	1.40e-03	36	87	3	M39831
Pathway	REACTOME_BICARBONATE_TRANSPORTERS	SLC4A3 SLC4A4	1.64e-03	10	87	2	M27335
Pathway	REACTOME_BICARBONATE_TRANSPORTERS	SLC4A3 SLC4A4	1.64e-03	10	87	2	MM15073
Pathway	REACTOME_RHOBTB3_ATPASE_CYCLE	VHLL LRRC41	2.00e-03	11	87	2	MM15681
Pathway	REACTOME_DAG_AND_IP3_SIGNALING	ITPR1 ITPR2 ITPR3	2.04e-03	41	87	3	M512
Pathway	REACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING	ITPR1 ITPR2 ITPR3 SCRIB MOV10	2.08e-03	146	87	5	M27288
Pubmed	Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.	ITPR1 ITPR2 ITPR3	3.16e-08	3	111	3	10874040
Pubmed	Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.	ITPR1 ITPR2 ITPR3	3.16e-08	3	111	3	9808793
Pubmed	Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.	ITPR1 ITPR2 ITPR3	3.16e-08	3	111	3	20395455
Pubmed	Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.	ITPR1 ITPR2 ITPR3	3.16e-08	3	111	3	17437169
Pubmed	Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.	ITPR1 ITPR2 ITPR3	3.16e-08	3	111	3	18194433
Pubmed	Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.	ITPR1 ITPR2 ITPR3	3.16e-08	3	111	3	18547250
Pubmed	Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.	ITPR1 ITPR2 ITPR3	3.16e-08	3	111	3	36350267
Pubmed	IP3 receptors regulate vascular smooth muscle contractility and hypertension.	ITPR1 ITPR2 ITPR3	3.16e-08	3	111	3	27777977
Pubmed	The versatility and universality of calcium signalling.	ITPR1 ITPR2 ITPR3	3.16e-08	3	111	3	11413485
Pubmed	Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR2 ITPR3	3.16e-08	3	111	3	26009177
Pubmed	Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.	ITPR1 ITPR2 ITPR3	3.16e-08	3	111	3	17581770
Pubmed	Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.	ITPR1 ITPR2 ITPR3	3.16e-08	3	111	3	18241669
Pubmed	Receptor-activated single channels in intact human platelets.	ITPR1 ITPR2 ITPR3	3.16e-08	3	111	3	1693919
Pubmed	Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.	ITPR1 ITPR2 ITPR3	3.16e-08	3	111	3	19068129
Pubmed	Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.	ITPR1 ITPR2 ITPR3	3.16e-08	3	111	3	23955339
Pubmed	Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.	ITPR1 ITPR2 ITPR3	3.16e-08	3	111	3	31979185
Pubmed	Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.	ITPR1 ITPR2 ITPR3	3.16e-08	3	111	3	24904548
Pubmed	Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR2 ITPR3	3.16e-08	3	111	3	17327232
Pubmed	Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation.	ITPR1 ITPR2 ITPR3	3.16e-08	3	111	3	16014380
Pubmed	Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice.	ITPR1 ITPR2 ITPR3	3.16e-08	3	111	3	17890015
Pubmed	Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.	ITPR1 ITPR2 ITPR3	3.16e-08	3	111	3	23983250
Pubmed	Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.	ITPR1 ITPR2 ITPR3	3.16e-08	3	111	3	9858485
Pubmed	Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.	ITPR1 ITPR2 ITPR3	3.16e-08	3	111	3	20427533
Pubmed	Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.	ITPR1 ITPR2 ITPR3	1.26e-07	4	111	3	25215520
Pubmed	Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B.	ITPR1 ITPR2 ITPR3	1.26e-07	4	111	3	21424589
Pubmed	Loss of IP3 Receptor-Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function.	ITPR1 ITPR2 ITPR3	1.26e-07	4	111	3	28615414
Pubmed	Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes.	ITPR1 ITPR2 ITPR3	1.26e-07	4	111	3	10828023
Pubmed	IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway.	ITPR1 ITPR2 ITPR3	1.26e-07	4	111	3	28419336
Pubmed	Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR2 ITPR3	1.26e-07	4	111	3	11163362
Pubmed	IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming.	ITPR1 ITPR2 ITPR3	1.26e-07	4	111	3	35494252
Pubmed	A protein interaction landscape of breast cancer.	ERCC2 MTHFD2 ANXA3 CUL9 TOR4A KEAP1 RBM28 ITPR3 RIN1 MICAL2 LRCH4 PTCD3 KPNA3	1.27e-07	634	111	13	34591612
Pubmed	InsP₃receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences.	ITPR1 ITPR2 ITPR3	3.15e-07	5	111	3	21568942
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	NDST1 ERCC2 INTS1 HECTD4 CUL9 TOR4A RHOT2 EDC4 ZNF865 ATP13A2 CDC42BPB ITPR2 TPCN1 ITPR3 ARHGEF40 SBF2	4.67e-07	1105	111	16	35748872
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ERCC2 MTHFD2 PEX1 CUL9 RHOT2 KEAP1 TAF6L VPS52 ARHGEF40 TAF7L SCRIB TAF4B LRRC41 ZNF574 PTCD3 KPNA3	5.32e-07	1116	111	16	31753913
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	ITPR1 ITPR2 ITPR3	6.28e-07	6	111	3	23463619
Pubmed	Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release.	ITPR1 ITPR2 ITPR3	6.28e-07	6	111	3	21762810
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	ITPR1 ITPR2 ITPR3	6.28e-07	6	111	3	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	ITPR1 ITPR2 ITPR3	6.28e-07	6	111	3	25966694
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	ITPR1 ITPR2 ITPR3	6.28e-07	6	111	3	16844763
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	ITPR1 ITPR2 ITPR3	1.10e-06	7	111	3	11860456
Pubmed	Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.	ITPR1 ITPR2 ITPR3	1.10e-06	7	111	3	22495310
Pubmed	Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.	ITPR1 ITPR2 ITPR3	2.62e-06	9	111	3	25737585
Pubmed	Type 1 and 3 inositol trisphosphate receptors are required for extra-embryonic vascular development.	ITPR1 ITPR2 ITPR3	5.12e-06	11	111	3	27514653
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	MTHFD2 SARM1 PEX1 RHOT2 NDUFA2 RBM28 ITPR1 ITPR2 ITPR3 VPS52 SNX6 COQ9 NOC4L WDR41 TMED10 MOV10 PTCD3	5.34e-06	1496	111	17	32877691
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	ITPR1 ITPR2 ITPR3 CACNA1G	6.67e-06	38	111	4	30786075
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	UTP6 POLA1 NOL6 INTS1 CUL9 RBM28 EDC4 ITPR3 NOC4L MOV10 PTCD3	8.15e-06	653	111	11	22586326
Pubmed	Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin.	ITPR2 ITPR3	1.01e-05	2	111	2	9065779
Pubmed	Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve.	ITPR2 ITPR3	1.01e-05	2	111	2	17496801
Pubmed	Mutational analysis of the ligand binding site of the inositol 1,4,5-trisphosphate receptor.	ITPR1 ITPR3	1.01e-05	2	111	2	8663526
Pubmed	The Pro335 --> Leu polymorphism of type 3 inositol 1,4,5-trisphosphate receptor found in mouse inbred lines results in functional change.	ITPR1 ITPR3	1.01e-05	2	111	2	15890645
Pubmed	Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye.	ITPR2 ITPR3	1.01e-05	2	111	2	24901844
Pubmed	Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization.	ITPR2 ITPR3	1.01e-05	2	111	2	33854148
Pubmed	An antidepressant behaviour in mice carrying a gene-specific InsP3R1, InsP3R2 and InsP3R3 protein knockdown.	ITPR1 ITPR2	1.01e-05	2	111	2	18708078
Pubmed	Immunolocalization of type 2 inositol 1,4,5-trisphosphate receptors in cardiac myocytes from newborn mice.	ITPR1 ITPR2	1.01e-05	2	111	2	15201137
Pubmed	Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors.	ITPR2 ITPR3	1.01e-05	2	111	2	19528657
Pubmed	Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction.	ITPR2 ITPR3	1.01e-05	2	111	2	8063813
Pubmed	Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors.	ITPR2 ITPR3	1.01e-05	2	111	2	8081734
Pubmed	Sulphide signalling potentiates apoptosis through the up-regulation of IP3 receptor types 1 and 2.	ITPR1 ITPR2	1.01e-05	2	111	2	23582047
Pubmed	Three additional inositol 1,4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues.	ITPR1 ITPR3	1.01e-05	2	111	2	1374893
Pubmed	IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism.	ITPR2 ITPR3	1.01e-05	2	111	2	16195467
Pubmed	Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant.	ITPR2 ITPR3	1.01e-05	2	111	2	15632133
Pubmed	Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening.	ITPR1 ITPR3	1.01e-05	2	111	2	20813840
Pubmed	Inositol (1,4,5)-trisphosphate receptor links to filamentous actin are important for generating local Ca2+ signals in pancreatic acinar cells.	ITPR2 ITPR3	1.01e-05	2	111	2	15713744
Pubmed	Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cells.	ITPR1 ITPR3	1.01e-05	2	111	2	7559486
Pubmed	Structural studies of inositol 1,4,5-trisphosphate receptor: coupling ligand binding to channel gating.	ITPR1 ITPR3	1.01e-05	2	111	2	20843799
Pubmed	Type 1 and 2 IP3 receptors respond differently to catecholamines and stress.	ITPR1 ITPR2	1.01e-05	2	111	2	19120126
Pubmed	Distinct roles of inositol 1,4,5-trisphosphate receptor types 1 and 3 in Ca2+ signaling.	ITPR1 ITPR3	1.01e-05	2	111	2	14707143
Pubmed	Evidence That ITPR2-Mediated Intracellular Calcium Release in Oligodendrocytes Regulates the Development of Carbonic Anhydrase II + Type I/II Oligodendrocytes and the Sizes of Myelin Fibers.	ITPR1 ITPR2 ITPR3	1.12e-05	14	111	3	34630045
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	MTHFD2 NOL6 RHOT2 RBM28 EDC4 ITPR1 ITPR2 ITPR3 FBXO6 CNOT9 NOC4L SCRIB TMED10 MOV10 PTCD3 KPNA3	1.37e-05	1440	111	16	30833792
Pubmed	Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle.	ITPR1 ITPR2 ITPR3	1.40e-05	15	111	3	28578927
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	NDST1 PDGFRB RBL2 PLA2G3 IQSEC2 HECTD4 CUL9 ZNFX1 CDC42BPB SLC4A3 LIMK1 SNX6 MICAL2 SCRIB KPNA3	1.48e-05	1285	111	15	35914814
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	NDST1 PDGFRB SLIT3 FOXH1 DNAH11	1.79e-05	100	111	5	25807483
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	HAUS6 MTHFD2 POLA1 RBL2 INTS1 KEAP1 EDC4 TAF6L VPS52 TINF2 NOC4L TMED10 LRRC41 ZNF574 KPNA3	2.15e-05	1327	111	15	32694731
Pubmed	Rescue of calcineurin Aα(-/-) mice reveals a novel role for the α isoform in the salivary gland.	ITPR2 ITPR3	3.02e-05	3	111	2	21435446
Pubmed	Gene mapping within the T/t complex of the mouse. I. t-Lethal genes are nonallelic.	ITPR3 VPS52	3.02e-05	3	111	2	7074682
Pubmed	Identification of KRAP-expressing cells and the functional relevance of KRAP to the subcellular localization of IP3R in the stomach and kidney.	ITPR1 ITPR3	3.02e-05	3	111	2	22992961
Pubmed	Intragenic enhancers act as alternative promoters.	ZNFX1 TG	3.02e-05	3	111	2	22264824
Pubmed	Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels.	ITPR1 ITPR3	3.02e-05	3	111	2	12032348
Pubmed	Inositol 1,4,5-trisphosphate receptors are essential for fetal-maternal connection and embryo viability.	ITPR1 ITPR2	3.02e-05	3	111	2	32320395
Pubmed	Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission.	KEAP1 VPS52	3.02e-05	3	111	2	27889639
Pubmed	Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility.	LNX2 CDC42BPB	3.02e-05	3	111	2	21471979
Pubmed	Rare and common genetic variations in the Keap1/Nrf2 antioxidant response pathway impact thyroglobulin gene expression and circulating levels, respectively.	KEAP1 TG	3.02e-05	3	111	2	31421134
Pubmed	Ubiquitination and proteasomal degradation of endogenous and exogenous inositol 1,4,5-trisphosphate receptors in alpha T3-1 anterior pituitary cells.	ITPR1 ITPR3	3.02e-05	3	111	2	12421829
Pubmed	Type 1 inositol (1,4,5)-trisphosphate receptor activates ryanodine receptor 1 to mediate calcium spark signaling in adult mammalian skeletal muscle.	ITPR1 ITPR2	3.02e-05	3	111	2	23223241
Pubmed	Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis.	ITPR1 ITPR3	3.02e-05	3	111	2	18250332
Pubmed	Regulation of type 1 inositol 1,4,5-triphosphate receptor by dopamine receptors in cocaine-induced place conditioning.	DRD1 ITPR1	3.02e-05	3	111	2	22033896
Pubmed	Possible involvement of type 1 inositol 1,4,5-trisphosphate receptors up-regulated by dopamine D1 and D2 receptors in mouse nucleus accumbens neurons in the development of methamphetamine-induced place preference.	DRD1 ITPR1	3.02e-05	3	111	2	23000618
Pubmed	The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity.	ITPR1 ITPR2 ITPR3	4.66e-05	22	111	3	11696558
Pubmed	p62/SQSTM1 is involved in cisplatin resistance in human ovarian cancer cells via the Keap1-Nrf2-ARE system.	KEAP1 VPS52	6.03e-05	4	111	2	25269472
Pubmed	Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor.	ITPR2 ITPR3	6.03e-05	4	111	2	17925404
Pubmed	Dopamine-Evoked Synaptic Regulation in the Nucleus Accumbens Requires Astrocyte Activity.	DRD1 ITPR2	6.03e-05	4	111	2	31954621
Pubmed	Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl.	ITPR1 ITPR2	6.03e-05	4	111	2	21818117
Pubmed	IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis.	ITPR2 ITPR3	6.03e-05	4	111	2	26193638
Pubmed	The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage.	ITPR1 ITPR3	6.03e-05	4	111	2	23884412
Pubmed	Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins.	ITPR1 ITPR3	6.03e-05	4	111	2	14685260
Pubmed	Ins(1,4,5)P3 receptor-mediated Ca2+ signaling and autophagy induction are interrelated.	ITPR1 ITPR3	6.03e-05	4	111	2	22082873
Pubmed	Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.	ITPR1 ITPR2	6.03e-05	4	111	2	19120137
Pubmed	Stabilization of cortical actin induces internalization of transient receptor potential 3 (Trp3)-associated caveolar Ca2+ signaling complex and loss of Ca2+ influx without disruption of Trp3-inositol trisphosphate receptor association.	ITPR1 ITPR3	6.03e-05	4	111	2	11524429
Pubmed	Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.	ITPR1 ITPR2 ITPR3	6.10e-05	24	111	3	10843712
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	NOL6 HECTD4 RBM28 ITPR1 ITPR2 ITPR3 SCRIB MOV10	8.73e-05	440	111	8	34244565
GeneFamily	Inositol 1,4,5-triphosphate receptors\|Protein phosphatase 1 regulatory subunits	ITPR1 ITPR2 ITPR3	7.14e-08	3	76	3	297
GeneFamily	UPF1 like RNA helicases	ZNFX1 MOV10	9.36e-04	11	76	2	1169
GeneFamily	Myotubularins\|Phosphoinositide phosphatases	MTMR11 SBF2	1.77e-03	15	76	2	903
GeneFamily	Dyneins, axonemal	DNAH17 DNAH11	2.28e-03	17	76	2	536
Drug	CAS 298-57-7	DRD1 ITPR1 TPCN1 ITPR3 CACNG6 CACNA1G	1.37e-06	73	109	6	CID000002761
Drug	Calycanthine [595-05-1]; Down 200; 11.6uM; MCF7; HT_HG-U133A	GPR137 GALNT14 NDST1 RBL2 RHOT2 TPCN1 RIN1 TAF4B	4.73e-06	196	109	8	2764_DN
Drug	3-nitropropionic acid; Up 200; 10uM; MCF7; HT_HG-U133A	PDGFRB ITPR1 ITPR2 ARHGEF40 DNAH17 ASB4 SLC4A4 MUC6	4.91e-06	197	109	8	6367_UP
Drug	isovalerate	DRD1 ANXA3 TPCN1 MSRA CACNG6 CACNA1G LRRC41	5.81e-06	143	109	7	CID000010430
Drug	Cinildipine	ITPR1 TPCN1 ITPR3 CACNG6 CACNA1G	7.21e-06	56	109	5	CID000002752
Drug	nilvadipine	ITPR1 TPCN1 ITPR3 CACNG6 CACNA1G	1.02e-05	60	109	5	CID000004494
Drug	lercanidipine	ITPR1 TPCN1 ITPR3 CACNG6 CACNA1G	1.29e-05	63	109	5	CID000065866
Drug	gallopamil	ITPR1 TPCN1 ITPR3 CACNG6 CACNA1G	1.75e-05	67	109	5	CID000001234
Drug	Gsts	ERCC2 ANXA3 KEAP1 MSRA VPS52 AP4M1 SLC4A4	2.01e-05	173	109	7	CID000128079
Drug	AC1L2AC7	ITPR1 TPCN1 ITPR3 CACNG6 CACNA1G	2.02e-05	69	109	5	CID000068733
Drug	adenophostin A	ITPR2 ITPR3	2.27e-05	2	109	2	ctd:C085029
Drug	Isocaffeine	ITPR1 ITPR3	2.27e-05	2	109	2	CID000001326
Drug	adenophostin B	ITPR1 ITPR3	2.27e-05	2	109	2	CID000656722
Drug	benzene 1,2,4-trisphosphate	ITPR1 ITPR3	2.27e-05	2	109	2	CID000192376
Drug	ethosuximide	ITPR1 TPCN1 ITPR3 CACNG6 CACNA1G	2.84e-05	74	109	5	CID000003291
Drug	pimozide	DRD1 ITPR1 TPCN1 ITPR3 CACNG6 CACNA1G	3.39e-05	127	109	6	CID000016362
Drug	nisoldipine	ITPR1 TPCN1 ITPR3 CACNG6 CACNA1G	3.67e-05	78	109	5	CID000004499
Drug	0179445-0000 [211246-22-9]; Down 200; 10uM; PC3; HT_HG-U133A	GPR137 PEX1 CUL9 ITPR1 LIMK1 ARHGEF40 MTMR11	3.79e-05	191	109	7	4289_DN
Drug	Chlorzoxazone [95-25-0]; Down 200; 23.6uM; HL60; HG-U133A	NDST1 ERCC2 RBL2 RHOT2 KEAP1 SNX6 WDR41	4.19e-05	194	109	7	1416_DN
Drug	Xylometazoline hydrochloride [1218-35-5]; Up 200; 14.2uM; MCF7; HT_HG-U133A	GPR137 DRD1 SARM1 GIPR LIMK1 CACNA1G MUC6	4.47e-05	196	109	7	2270_UP
Drug	Testosterone propionate [57-85-2]; Down 200; 11.6uM; MCF7; HT_HG-U133A	POMT2 GPR137 CUL9 ITPR2 TPCN1 LIMK1 ZNF574	4.47e-05	196	109	7	5636_DN
Drug	Sulfaphenazole [526-08-9]; Down 200; 12.8uM; MCF7; HT_HG-U133A	GPR137 NOL6 RHOT2 TINF2 MICAL2 AP4M1 SLC4A4	4.62e-05	197	109	7	5507_DN
Drug	Norethindrone [68-22-4]; Down 200; 13.4uM; PC3; HT_HG-U133A	GPR137 GALNT14 SARM1 EDC4 LIMK1 TINF2 SLC4A4	4.62e-05	197	109	7	5055_DN
Drug	Suprofen [40828-46-4]; Down 200; 15.4uM; HL60; HT_HG-U133A	PLA2G3 TOR4A ITPR3 TAF6L RIN1 SLC4A4 MUC6	4.62e-05	197	109	7	3005_DN
Drug	1zz2	ERCC2 NDUFA2 EDC4 SLC4A3 TMED10	4.67e-05	82	109	5	CID005287728
Drug	ICI 182,780; Down 200; 0.01uM; PC3; HT_HG-U133A	POMT2 GPR137 NOL6 RHOT2 ITPR1 TPCN1 ZNF574	4.77e-05	198	109	7	1238_DN
Drug	Zalcitabine [7481-89-2]; Down 200; 19uM; MCF7; HT_HG-U133A	GPR137 PLA2G3 RHOT2 TPCN1 LIMK1 MICAL2 LRRC41	4.92e-05	199	109	7	4799_DN
Drug	alpha-estradiol; Down 200; 0.01uM; PC3; HT_HG-U133A	POMT2 GPR137 ERCC2 NOL6 PEX1 TINF2 ZNF574	4.92e-05	199	109	7	1210_DN
Drug	DAPH; Up 200; 10uM; PC3; HG-U133A	GPR137 POLA1 NOL6 RHOT2 TPCN1 SLIT3 NOC4L	4.92e-05	199	109	7	578_UP
Drug	5-deoxy-5-fluoro-myo-inositol	ITPR1 ITPR3	6.79e-05	3	109	2	CID000195110
Drug	fullerene C60	LNX2 PDGFRB KEAP1 EDC4 ATP13A2 CDC42BPB TPCN1 ITPR3 TG TAF6L LIMK1 TINF2 RAPGEF3 DNAH17 PTCH2 CACNA1G TAF4B MUC6 ZNF574	8.47e-05	1498	109	19	ctd:C069837
Drug	manidipine	ITPR1 TPCN1 ITPR3 CACNG6 CACNA1G	9.43e-05	95	109	5	CID000004008
Drug	nitrendipine	ITPR1 TPCN1 ITPR3 CACNG6 CACNA1G	1.09e-04	98	109	5	CID000004507
Drug	isradipine	ITPR1 TPCN1 ITPR3 CACNG6 CACNA1G	1.20e-04	100	109	5	CID000003784
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	ITPR1 ITPR2 ITPR3	1.05e-05	12	109	3	DOID:1441 (implicated_via_orthology)
Disease	Hypoxic Brain Damage	ITPR1 ITPR2	1.35e-05	2	109	2	C1140716
Disease	Anoxic Encephalopathy	ITPR1 ITPR2	1.35e-05	2	109	2	C0003132
Disease	Brain Hypoxia	ITPR1 ITPR2	1.35e-05	2	109	2	C1527348
Disease	Anoxia of brain	ITPR1 ITPR2	1.35e-05	2	109	2	C0995195
Disease	diastolic blood pressure, alcohol drinking	NEK10 HECTD4 MSRA SLIT3 MOV10	7.88e-05	118	109	5	EFO_0004329, EFO_0006336
Disease	protein wnt-7a measurement	STXBP5 SARM1	8.07e-05	4	109	2	EFO_0020689
Disease	urinary potassium to creatinine ratio	NEK10 GIPR	2.01e-04	6	109	2	EFO_0009882
Disease	Chronic Obstructive Asthma	MSRA TAF4B	2.01e-04	6	109	2	EFO_0009759
Disease	mean arterial pressure, alcohol drinking	NEK10 HECTD4 SLIT3 MOV10	4.87e-04	98	109	4	EFO_0004329, EFO_0006340
Disease	WNT1-inducible-signaling pathway protein 1 measurement	SARM1 TG	5.97e-04	10	109	2	EFO_0008321
Disease	congenital diaphragmatic hernia (implicated_via_orthology)	NDST1 SLIT3	8.71e-04	12	109	2	DOID:3827 (implicated_via_orthology)
Disease	hypertension	STXBP5 SARM1 HECTD4 MSRA SBF2 MOV10	9.98e-04	307	109	6	EFO_0000537
Disease	kallikrein-12 measurement	KLK11 SARM1	1.03e-03	13	109	2	EFO_0008194
Disease	obesity (implicated_via_orthology)	DRD1 ITPR1 ITPR2 ITPR3 MED12L	1.24e-03	215	109	5	DOID:9970 (implicated_via_orthology)
Disease	systolic blood pressure, alcohol drinking	NEK10 HECTD4 MSRA MOV10	1.32e-03	128	109	4	EFO_0004329, EFO_0006335
Disease	Williams-Beuren syndrome (implicated_via_orthology)	LIMK1 NSUN5P2	1.38e-03	15	109	2	DOID:1928 (implicated_via_orthology)
Disease	Ischemic stroke, tissue plasminogen activator measurement	STXBP5 HECTD4	1.38e-03	15	109	2	EFO_0004791, HP_0002140
Disease	N-acetylmethionine measurement	ITPR1 MICAL2	1.38e-03	15	109	2	EFO_0021427
Disease	anemia (implicated_via_orthology)	SLC4A3 SLC4A4	1.38e-03	15	109	2	DOID:2355 (implicated_via_orthology)
Disease	Huntington's disease (biomarker_via_orthology)	DRD1 ITPR1	1.57e-03	16	109	2	DOID:12858 (biomarker_via_orthology)
Disease	neurodegenerative disease (implicated_via_orthology)	SARM1 RHOT2 MTMR11 PTCH2	2.09e-03	145	109	4	DOID:1289 (implicated_via_orthology)
Disease	sensorineural hearing loss (implicated_via_orthology)	LNX2 DNAH17	2.22e-03	19	109	2	DOID:10003 (implicated_via_orthology)
Disease	factor VIII measurement, Ischemic stroke	STXBP5 HECTD4	2.22e-03	19	109	2	EFO_0004630, HP_0002140
Disease	maximal midexpiratory flow rate	GALNT14 MED12L	2.46e-03	20	109	2	EFO_0004313
Disease	Alzheimer's disease (is_marker_for)	ERCC2 DRD1 NDUFA2 ITPR1 TMED10	2.70e-03	257	109	5	DOID:10652 (is_marker_for)
Disease	Infiltrating duct carcinoma of female breast	PDGFRB CDC42BPB	2.71e-03	21	109	2	C3165106
Disease	hyperglycemia (biomarker_via_orthology)	DRD1 GIPR	2.71e-03	21	109	2	DOID:4195 (biomarker_via_orthology)
Disease	Parkinson's disease (implicated_via_orthology)	DRD1 RHOT2 ATP13A2 PTCH2	2.78e-03	157	109	4	DOID:14330 (implicated_via_orthology)
Disease	infant body height	ZNFX1 MTMR11	3.25e-03	23	109	2	EFO_0006785
Disease	leptin measurement	DRD1 RBM28 SLIT3	3.39e-03	81	109	3	EFO_0005000

Protein segments in the cluster

Peptide	Gene	Start	Entry
PGQRRLDLFSCLLRH	BRINP3	716	Q76B58
LRHCLLPRLFQDREL	SLC4A3	1191	P48751
PVFLQVHLRSARRLC	ADCK1	76	Q86TW2
LIKSSCRPQFQRRFH	ADAM5	6	Q6NVV9
FLRELQGCATHPLRI	ARHGEF40	1141	Q8TER5
AIRRTLHNRCHRAIP	ASB4	391	Q9Y574
CVRNTPAFLAERLHR	ANXA3	246	P12429
HVVRCYLRLSDNPRA	CNOT9	231	Q92600
ELYLRPLRRHIQCLQ	DNAH11	336	Q96DT5
LLILSLFRRLHCTRN	GIPR	156	P48546
NTLVCAAVIRFRHLR	DRD1	41	P21728
VFRHSVRALLQRVSP	CACNG6	191	Q9BXT2
THVPARQLLLNCRLV	FBXO6	26	Q9NRD1
LPRHTCSGLQVRFLR	AP4M1	411	O00189
NIFVSRTRLCLHNLP	RBM28	481	Q9NW13
VVSRCRLRHTEVLPA	EDC4	466	Q6P2E9
VPRNSYVRLRHLCTN	ITPR2	381	Q14571
VPRNSYVRLRHLCTN	ITPR3	381	Q14573
RRACQLLLLHSLFPV	MSRA	6	Q9UJ68
VSRIPVSFCRLRHLQ	LRCH4	216	O75427
RICPENHSALLRRLQ	RBL2	1116	Q08999
LVLIAFCIIRRRPSA	CD68	336	P34810
PGRRLVLTLQVFSHC	MUC6	2416	Q6W4X9
CLRRFHVFARSPALQ	PTCD3	341	Q96EY7
LFLRLLRSPHQNVCE	KPNA3	161	O00505
LFRLQPATLHCRLLR	MAP10	96	Q9P2G4
RMTCRLLLHLFRAPQ	MED12L	1126	Q86YW9
IRHNLSSNRCFRKVP	FOXH1	81	O75593
RLGHLLCRSRNPDFL	INTS1	861	Q8N201
LCRSRNPDFLLHIIQ	INTS1	866	Q8N201
LVPRNSYVRLRHLCT	ITPR1	381	Q14643
QLAHLRLRALCLPDS	MTMR11	316	A4FU01
SSLPRVARCYRHNRL	SBF2	1166	Q86WG5
LLVNVLCAVLSHRRR	GPR137	151	Q96N19
CRDFRLRAAHLPLLT	IQSEC2	581	Q5JU85
PCNTLHLTVLRERRF	LNX2	306	Q8N448
RRTVCLNLPVLTLQH	HTD2	16	P86397
RAPSIHFLRVLICLR	NEK10	126	Q6ZWH5
RALCHALTFPSLQRL	NSUN5P2	156	Q63ZY6
LRPLSRLQAACHRLK	NOL6	476	Q9H6R4
CLRRLCRHVSPQAVL	NDST1	6	P52848
QLRLPHTLRCANITI	KLK11	186	Q9UBX7
PLRFCAERLRSLLHT	ERCC2	371	P18074
LRRFPLHVCSFRELV	LRRC10	41	Q5BKY1
RNVECLQPLTHLKRR	PTPDC1	376	A2A3K4
HATRRDIPCIFRVTA	CDC42BPB	1166	Q9Y5S2
FCLRQFPRSLLERHQ	CYHR1	141	Q6ZMK1
INQLCRHLAITPARL	HECTD4	3471	Q9Y4D8
PTCRNRTRHLPLQFS	POLA1	1351	P09884
THRLLFRCPRLLNLG	RDH8	281	Q9NYR8
RAIPDTRHLRCTLLV	GALNT14	91	Q96FL9
VRLRLRQRQPHVCYE	CCDC105	461	Q8IYK2
SRLRRQGIFCIHPLR	ATP13A2	486	Q9NQ11
RPRASHVLCHIRFPL	KLHL26	241	Q53HC5
PQSRFRLLCHRIITH	CACNA1G	1261	O43497
AHICRINRILESPRG	DNAH17	2781	Q9UFH2
IARCHFARSRFLQIL	HAUS6	166	Q7Z4H7
ALLRAVRCHSLTPNF	KEAP1	266	Q14145
LLQLCPRLNRVLRHE	CUL9	1336	Q8IWT3
ASFASRVRRLCHLLV	CUL9	1416	Q8IWT3
ARCRQALVPRAFHAS	COQ9	26	O75208
NICHLRRFRSVPRNL	ECM1	311	Q16610
SIILCQDSIHPRRRR	GRIK4	851	Q16099
ICNLLRRHPACRVLV	NOC4L	391	Q9BVI4
FTNARDCFLHLPRRL	PEX1	21	O43933
RSGLALCAIIHRFRP	MICAL2	546	O94851
LCAIIHRFRPELINF	MICAL2	551	O94851
RLQHVDRPLSVRCTL	PDGFRB	496	P09619
ARLTRGLECPALQHR	ARHGAP30	441	Q7Z6I6
AIRLRLCSVHIPQAK	MROH5	781	Q6ZUA9
LREIRIHLCQRSPGS	NDUFA2	16	O43678
FRELLRCALVRARPA	RASL10A	171	Q92737
VHPIILLFSNCRLRA	TAS2R60	291	P59551
QLHRPRITRICLRDL	TAF4B	826	Q92750
LLQVARSLFRNPHLC	TAF6L	216	Q9Y6J9
QFILRLPLEHACTVR	TAF7L	101	Q5H9L4
ARQLFLRALRFHPEC	UTP6	161	Q9NYH9
RRLPATHCFQHLLRV	RIN1	616	Q13671
HLCSRLINGPYRRTV	TCEANC2	161	Q96MN5
LLETFRPQRCAQVLH	TDRD6	331	O60522
RSRIRFIHLVTGCVL	POMT2	471	Q9UKY4
DRRLCDQRFSPLLHS	LRRC41	146	Q15345
LRPACAQALTRIFRL	RHOT2	181	Q8IXI1
DLLCQRLRVHLPSSI	MOV10	561	Q9HCE1
PCLALILHVECRARR	MRGPRF	216	Q96AM1
CSLRLRPFHLAAVRN	MTHFD2	21	P13995
AAFHVFRIECPRRLS	SAMD3	471	Q8N6K7
FPAILSLDLRRRHCQ	PTCH2	546	Q9Y6C5
RELSRIIICNHSPRI	VHLL	51	Q6RSH7
PLRQRHVACLARSER	SCRIB	856	Q14160
RCRRPTHLSAVVCVL	MRGPRX4	131	Q96LA9
RPAILHSLKFCRERV	STXBP5	131	Q5T5C0
NCTRRLARFLRLHSP	PLA2G3	396	Q9NZ20
QAIFHVAIRRRCRPS	HTR3D	216	Q70Z44
CFVRSLLRVQLLPRT	LINC01619	61	G3V211
FLAHRVALAALPCRR	RNASEH1	6	O60930
LRCIPVHAFNGLRSL	SLIT3	811	O75094
CIHIVLRFRNIAAKR	VPS52	446	Q8N1B4
RHLLATCPNLIRDRK	RAPGEF3	106	O95398
LTRHRQVHRLQLPCA	ZNF865	621	P0CJ78
RRTDPALLRHCALAL	SARM1	216	Q6SZW1
AISFHLPINSRKCLR	TMED10	31	P49755
RCVEHFPRVLEFLRS	TINF2	26	Q9BSI4
LSRADLVLLAHRPRC	TOMT	206	Q8WZ04
ECPRSFLLRRLLEVH	ZNF574	611	Q6ZN55
LCRFRIRQLVRIDHI	SOCS7	521	O14512
VFLCRVAAHPILRRD	SNX6	146	Q9UNH7
RFHERCQQPCKRLLI	ZNFX1	1456	Q9P2E3
LICRRLCQFSTRVHP	ZDHHC11	361	Q9H8X9
SHVRVTRALRCIFLV	TPCN1	196	Q9ULQ1
KDRVLPHRRQVSLAC	FP248	111	Q71RG6
PRVEHRSRAQRCLLL	TOR4A	111	Q9NXH8
PLRRVHLFTFLQVLC	SLC4A4	946	Q9Y6R1
RRQVLSGHLPFCRFR	VRTN	516	Q9H8Y1
PRSCEIRNRRLLHGV	TG	161	P01266
VLHVARLPNRQLISC	WDR41	326	Q9HAD4
SESLRVVCRPHRIFR	LIMK1	321	P53667