Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	glucokinase activity	HK1 HK3	2.56e-04	5	102	2	GO:0004340
GeneOntologyMolecularFunction	hexokinase activity	HK1 HK3	2.56e-04	5	102	2	GO:0004396
GeneOntologyMolecularFunction	fructokinase activity	HK1 HK3	2.56e-04	5	102	2	GO:0008865
GeneOntologyMolecularFunction	phosphatidylinositol-3,5-bisphosphate binding	HIP1 GBF1 HIP1R	5.24e-04	31	102	3	GO:0080025
GeneOntologyMolecularFunction	clathrin light chain binding	HIP1 HIP1R	5.34e-04	7	102	2	GO:0032051
GeneOntologyMolecularFunction	phosphatidylinositol phosphate binding	MYO1G HIP1 ANKFY1 GBF1 VEPH1 HIP1R	5.53e-04	199	102	6	GO:1901981
GeneOntologyMolecularFunction	phosphatidylinositol-3,4-bisphosphate binding	MYO1G HIP1 HIP1R	7.52e-04	35	102	3	GO:0043325
GeneOntologyMolecularFunction	enzyme regulator activity	RAF1 GBF1 NLRP7 RASA3 WNT11 TSC2 SIRPB1 AKT1S1 TGFA PLEKHG4B TXNIP PSME4 SERGEF DOCK7 IQSEC1 QARS1 PPP6R2	8.08e-04	1418	102	17	GO:0030234
GeneOntologyMolecularFunction	actin filament binding	MYO1G HIP1 MYH7B HIP1R SPTBN4 AFDN	1.10e-03	227	102	6	GO:0051015
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	GBF1 RASA3 WNT11 TSC2 SIRPB1 PLEKHG4B SERGEF DOCK7 IQSEC1	1.16e-03	507	102	9	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	GBF1 RASA3 WNT11 TSC2 SIRPB1 PLEKHG4B SERGEF DOCK7 IQSEC1	1.16e-03	507	102	9	GO:0030695
Domain	ARM-type_fold	HIP1 GBF1 CAND2 VEPH1 MROH5 TSC2 MEI1 PSME4 MROH6 MMS19 STKLD1 PPP6R2 TNPO3	6.44e-08	339	106	13	IPR016024
Domain	ARM-like	CAND2 MROH5 TSC2 MEI1 PSME4 MROH6 MMS19 STKLD1 PPP6R2 TNPO3	3.18e-06	270	106	10	IPR011989
Domain	HIP1_clath_bdg	HIP1 HIP1R	3.19e-05	2	106	2	PF16515
Domain	HIP1_clath-bd	HIP1 HIP1R	3.19e-05	2	106	2	IPR032422
Domain	Sla2_fam	HIP1 HIP1R	3.19e-05	2	106	2	IPR030224
Domain	ILWEQ_dom	HIP1 HIP1R	1.90e-04	4	106	2	IPR002558
Domain	ILWEQ	HIP1 HIP1R	1.90e-04	4	106	2	SM00307
Domain	ANTH_dom	HIP1 HIP1R	1.90e-04	4	106	2	IPR011417
Domain	ILWEQ	HIP1 HIP1R	1.90e-04	4	106	2	PD011820
Domain	ANTH	HIP1 HIP1R	1.90e-04	4	106	2	PF07651
Domain	-	HIP1 HIP1R	1.90e-04	4	106	2	1.20.1410.10
Domain	I_LWEQ	HIP1 HIP1R	1.90e-04	4	106	2	PF01608
Domain	I_LWEQ	HIP1 HIP1R	1.90e-04	4	106	2	PS50945
Domain	-	CAND2 MROH5 TSC2 PSME4 MROH6 MMS19 TNPO3	2.74e-04	222	106	7	1.25.10.10
Domain	Hexokinase_2	HK1 HK3	3.16e-04	5	106	2	PF03727
Domain	Hexokinase_BS	HK1 HK3	3.16e-04	5	106	2	IPR019807
Domain	Hexokinase_C	HK1 HK3	3.16e-04	5	106	2	IPR022673
Domain	Hexokinase_N	HK1 HK3	3.16e-04	5	106	2	IPR022672
Domain	Hexokinase_1	HK1 HK3	3.16e-04	5	106	2	PF00349
Domain	HEXOKINASE_2	HK1 HK3	3.16e-04	5	106	2	PS51748
Domain	HEXOKINASE_1	HK1 HK3	3.16e-04	5	106	2	PS00378
Domain	Hexokinase	HK1 HK3	4.72e-04	6	106	2	IPR001312
Domain	ENTH	HIP1 HIP1R	1.12e-03	9	106	2	PS50942
Domain	ENTH	HIP1 HIP1R	1.12e-03	9	106	2	SM00273
Domain	ENTH	HIP1 HIP1R	1.39e-03	10	106	2	IPR013809
Domain	-	GBF1 IQSEC1	3.19e-03	15	106	2	1.10.1000.11
Domain	Sec7	GBF1 IQSEC1	3.19e-03	15	106	2	PF01369
Domain	Sec7_alpha_orthog	GBF1 IQSEC1	3.19e-03	15	106	2	IPR023394
Domain	SEC7	GBF1 IQSEC1	3.64e-03	16	106	2	PS50190
Domain	Sec7	GBF1 IQSEC1	3.64e-03	16	106	2	SM00222
Domain	Sec7_dom	GBF1 IQSEC1	3.64e-03	16	106	2	IPR000904
Domain	RCC1	RCBTB1 SERGEF	5.67e-03	20	106	2	PF00415
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HIP1 GBF1 NUP85 RASA3 TMEM94 HIP1R TSC2 KDM6B TLNRD1 PSME4 SLC12A4 MROH6 CACNA1H TNPO3 PLXNA1	1.52e-06	1105	107	15	35748872
Pubmed	Genome-scale RNAi screen for host factors required for HIV replication.	ANKFY1 TRIM42 MROH5 DDO CCT2 CHST1 ADAMTS5 RNF5 EFCAB12	1.86e-06	361	107	9	18976975
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	RAF1 EXOSC9 GBF1 HK1 CAND2 CCT2 PHKA1 NAE1 DOCK7 GEMIN4 PRPF19 AFDN MMS19 QARS1 CTSB	2.45e-06	1149	107	15	35446349
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	RAF1 ANKFY1 GBF1 HK1 PHKA1 PSME4 DOCK7 AFDN	4.79e-06	304	107	8	32235678
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	RAF1 GBF1 HK1 CAND2 NUP85 POLD2 CCT2 TSC2 PSME4 NAE1 NUP210 GEMIN4 PRPF19 MMS19 QARS1	7.23e-06	1257	107	15	37317656
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	RAF1 EXOSC9 HIP1 HK1 CAND2 NUP85 CCT2 TSC2 NUP210 DOCK7 GEMIN4 PRPF19 MMS19 QARS1 CTSB TNPO3	8.52e-06	1440	107	16	30833792
Pubmed	Hip1-related mutant mice grow and develop normally but have accelerated spinal abnormalities and dwarfism in the absence of HIP1.	HIP1 HIP1R	9.38e-06	2	107	2	15121852
Pubmed	Degenerative phenotypes caused by the combined deficiency of murine HIP1 and HIP1r are rescued by human HIP1.	HIP1 HIP1R	9.38e-06	2	107	2	17452370
Pubmed	HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains.	HIP1 HIP1R	9.38e-06	2	107	2	14732715
Pubmed	The Sla2p/HIP1/HIP1R family: similar structure, similar function in endocytosis?	HIP1 HIP1R	9.38e-06	2	107	2	20074057
Pubmed	Tuberin and PRAS40 are anti-apoptotic gatekeepers during early human amniotic fluid stem-cell differentiation.	TSC2 AKT1S1	9.38e-06	2	107	2	22090422
Pubmed	TXNIP regulates germinal center generation by suppressing BCL-6 expression.	BCL6 TXNIP	9.38e-06	2	107	2	20156484
Pubmed	Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity.	HIP1 HIP1R	9.38e-06	2	107	2	17928447
Pubmed	High concentrations of glucose suppress etoposide-induced cell death of B-cell lymphoma through BCL-6.	BCL6 TXNIP	9.38e-06	2	107	2	24878528
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	GBF1 CCT2 TSC2 AKT1S1 DOCK7 PRPF19 AFDN	1.47e-05	255	107	7	15324660
Pubmed	[Evaluation of Gene Expression of Hexokinases in Colorectal Cancer with the Use of Bioinformatics Methods].	HK1 HK3	2.81e-05	3	107	2	26855992
Pubmed	HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin.	HIP1 HIP1R	2.81e-05	3	107	2	11063258
Pubmed	Dampened VEPH1 activates mTORC1 signaling by weakening the TSC1/TSC2 association in hepatocellular carcinoma.	VEPH1 TSC2	2.81e-05	3	107	2	32610114
Pubmed	A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression.	ADAMTS5 ADAMTS20	2.81e-05	3	107	2	24753090
Pubmed	Huntingtin interacting protein 1 (HIP1) regulates clathrin assembly through direct binding to the regulatory region of the clathrin light chain.	HIP1 HIP1R	2.81e-05	3	107	2	15533941
Pubmed	Deficiency of the Endocytic Protein Hip1 Leads to Decreased Gdpd3 Expression, Low Phosphocholine, and Kypholordosis.	HIP1 HIP1R	2.81e-05	3	107	2	30224518
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	EXOSC9 CLIP2 CCT2 TSC2 KDM6B SPTBN4 THAP4 RCBTB1 SERGEF AFDN TAF12 QARS1 CTSB ST18	4.07e-05	1285	107	14	35914814
Pubmed	Genome-wide CRISPR-cas9 knockout screening identifies GRB7 as a driver for MEK inhibitor resistance in KRAS mutant colon cancer.	GEMIN4 PRPF19 MMS19 TNPO3	4.39e-05	63	107	4	34718347
Pubmed	Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain.	HIP1 HIP1R	5.60e-05	4	107	2	18790740
Pubmed	Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism.	HK1 HK3	5.60e-05	4	107	2	25904018
Pubmed	Mesothelium of the murine allantois exhibits distinct regional properties.	ITGA4 AFDN	5.60e-05	4	107	2	21284019
Pubmed	High 18F-FDG uptake in PMAH correlated with normal expression of Glut1, HK1, HK2, and HK3.	HK1 HK3	5.60e-05	4	107	2	25766729
Pubmed	A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1-mediated adhesion in T cells.	RASA3 BCL6	5.60e-05	4	107	2	35857633
Pubmed	Genetic and age related models of neurodegeneration in mice: dystrophic axons.	ATP8A2 SPTBN4	5.60e-05	4	107	2	1634998
Pubmed	NOTCH4 potentiates the IL-13 induced genetic program in M2 alternative macrophages through the AP1 and IRF4-JMJD3 axis.	KDM6B NOTCH4	5.60e-05	4	107	2	37478314
Pubmed	Intrasteric inhibition mediates the interaction of the I/LWEQ module proteins Talin1, Talin2, Hip1, and Hip12 with actin.	HIP1 HIP1R	5.60e-05	4	107	2	15581353
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	RAF1 GBF1 CARMIL1 TSC2 ALPK1 AKT1S1 STARD9 DOCK7 IQSEC1 AFDN TNPO3	7.18e-05	861	107	11	36931259
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	RAF1 GBF1 TSC2 AKT1S1 DOCK7 AFDN QARS1 PPP6R2	7.40e-05	446	107	8	24255178
Pubmed	Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent.	RAF1 TSC2	9.32e-05	5	107	2	15150271
Pubmed	Mapping of two genes encoding members of a distinct subfamily of MAX interacting proteins: MAD to human chromosome 2 and mouse chromosome 6, and MXI1 to human chromosome 10 and mouse chromosome 19.	RAF1 TGFA	9.32e-05	5	107	2	8290278
Pubmed	ANTH domains within CALM, HIP1R, and Sla2 recognize ubiquitin internalization signals.	HIP1 HIP1R	9.32e-05	5	107	2	34821552
Pubmed	p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association.	RAF1 BCL6	9.32e-05	5	107	2	15849194
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	RAF1 USP30 CAND2 POLD2 HIP1R TSC2 NUP210 IQSEC1 CTSB	1.10e-04	606	107	9	36538041
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	EXOSC9 DDX59 HK1 NUP85 CLIP2 TSC2 BCL6 SLC12A4 PRPF19 QARS1 CTSB	1.35e-04	925	107	11	28986522
Pubmed	Mapping of the taurine transporter gene to mouse chromosome 6 and to the short arm of human chromosome 3.	RAF1 TGFA	1.40e-04	6	107	2	7774940
Pubmed	Phosphorylation and binding partner analysis of the TSC1-TSC2 complex.	TSC2 DOCK7	1.40e-04	6	107	2	15963462
Pubmed	Colocalization of transforming growth factor-alpha and a functional epidermal growth factor receptor (EGFR) to the inner cell mass and preferential localization of the EGFR on the basolateral surface of the trophectoderm in the mouse blastocyst.	TGFA CTSB	1.40e-04	6	107	2	1426645
Pubmed	Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits.	HIP1 HIP1R	1.40e-04	6	107	2	25122462
Pubmed	Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy.	HIP1 CLIP2	1.40e-04	6	107	2	15122254
Pubmed	Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo.	HIP1 HIP1R	1.40e-04	6	107	2	15533940
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	EFL1 ANKFY1 GBF1 HK1 NUP85 POLD2 CCT2 AKT1S1 PSME4 NAE1 PRPF19 MMS19 QARS1 TNPO3	1.52e-04	1455	107	14	22863883
Pubmed	A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes.	RAF1 TSC2 AKT1S1 AFDN	1.55e-04	87	107	4	17979178
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	ANKFY1 GBF1 NUP85 CCT2 NUP210 GEMIN4 PRPF19 QARS1 TNPO3	1.62e-04	638	107	9	33239621
Pubmed	Galnt1 is required for normal heart valve development and cardiac function.	ADAMTS5 GALNT16 ADAMTS20	1.88e-04	36	107	3	25615642
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	ANKFY1 CLIP2 TSC2 SIRPB1 FAM81A SPTBN4 KCNA4 DOCK7 IQSEC1 AFDN PPP6R2	1.91e-04	963	107	11	28671696
Pubmed	Molecular cloning, chromosomal mapping, and characteristic expression in tooth organ of rat and mouse Krox-25.	RAF1 NOTCH4	1.95e-04	7	107	2	14706453
Pubmed	Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation.	RAF1 AFDN	1.95e-04	7	107	2	11788587
Pubmed	GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion.	GBF1 IQSEC1	1.95e-04	7	107	2	18084281
Pubmed	HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain.	HIP1 HIP1R	1.95e-04	7	107	2	11889126
Pubmed	The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin.	RAF1 AFDN	1.95e-04	7	107	2	10922060
Pubmed	Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure.	NUP85 NUP210 TNPO3	2.57e-04	40	107	3	37516964
Pubmed	Molecular characterization of a novel human gene, SEC13R, related to the yeast secretory pathway gene SEC13, and mapping to a conserved linkage group on human chromosome 3p24-p25 and mouse chromosome 6.	RAF1 TGFA	2.59e-04	8	107	2	7987303
Pubmed	Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation.	ADAMTS5 ADAMTS20	2.59e-04	8	107	2	21041365
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	GBF1 NUP85 GEMIN4 MMS19 TNPO3	2.63e-04	183	107	5	23956138
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ANKFY1 HK1 RASA3 POLD2 HIP1R CCT2 PSME4 IQSEC1 GEMIN4 PRPF19 AFDN MMS19 QARS1	2.69e-04	1353	107	13	29467282
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	RAF1 GBF1 HIP1R CCT2 DOCK7 TNPO3	2.75e-04	288	107	6	23383273
Pubmed	Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry.	HIP1 HIP1R CCT2 CD163L1 PRPF19 QARS1 FAM98C	2.89e-04	411	107	7	36652389
Pubmed	Establishment of crown-root domain borders in mouse incisor.	WNT11 BARX2	3.33e-04	9	107	2	23684768
Pubmed	Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma.	HK1 HK3	3.33e-04	9	107	2	19554504
Pubmed	Single-cell analysis of murine long-term hematopoietic stem cells reveals distinct patterns of gene expression during fetal migration.	CASR ITGA4	3.33e-04	9	107	2	22276210
Pubmed	Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow.	RASA3 ITGA4	3.33e-04	9	107	2	37267105
Pubmed	Lactate downregulates the glycolytic enzymes hexokinase and phosphofructokinase in diverse tissues from mice.	HK1 HK3	3.33e-04	9	107	2	21074528
Pubmed	The Metabolic Reprogramming of Frem2 Mutant Mice Embryos in Cryptophthalmos Development.	HK1 FREM2	3.33e-04	9	107	2	33490088
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	RAF1 POLD2 ALPK1 WDR54 AKT1S1 CLASRP MROH6 DOCK7 IQSEC1 TAF12 PPP6R2	3.62e-04	1038	107	11	26673895
Pubmed	Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network.	CCT2 GEMIN4 MMS19 TNPO3	3.94e-04	111	107	4	32683582
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	CAND2 TSC2 TXNIP DOCK7 GEMIN4 MMS19	4.27e-04	313	107	6	38270169
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	EXOSC9 ANKFY1 GBF1 HK1 CCT2 STARD9 NUP210 DOCK7 GEMIN4 PRPF19 AFDN QARS1 PLXNA1	4.40e-04	1425	107	13	30948266
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	HK1 NUP85 NLRP7 MYH7B SKIDA1 CCT2 PLA2G4D SPTBN4 SLC12A4 KIAA0825 STARD9 EFCAB12 PRPF19	4.92e-04	1442	107	13	35575683
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	MYO1G CLIP2 PSME4 SLC12A4 MMS19 HTR3B	4.96e-04	322	107	6	26514267
Pubmed	The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression.	ITGA4 BCL6 KDM6B CTSB	5.12e-04	119	107	4	24162774
Pubmed	The TIP60 Complex Is a Conserved Coactivator of HIF1A.	GBF1 NUP210 MMS19 CTSB	5.29e-04	120	107	4	27320910
Pubmed	A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.	USP30 POLM CCT2 EFCAB12 NAE1 QARS1	5.73e-04	331	107	6	19490893
Pubmed	Isolation and genetic mapping of two novel members of the murine Wnt gene family, Wnt11 and Wnt12, and the mapping of Wnt5a and Wnt7a.	RAF1 WNT11	6.07e-04	12	107	2	7896292
Pubmed	Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival.	TSC2 AKT1S1	6.07e-04	12	107	2	23275438
Pubmed	Rheb binds and regulates the mTOR kinase.	RAF1 TSC2	6.07e-04	12	107	2	15854902
Pubmed	The GDNF target Vsnl1 marks the ureteric tip.	WNT11 FREM2	6.07e-04	12	107	2	21289216
Pubmed	Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.	ADAMTS5 ADAMTS20	6.07e-04	12	107	2	25770910
Pubmed	A generic approach for the purification of signaling complexes that specifically interact with the carboxyl-terminal domain of G protein-coupled receptors.	MYO1G CLIP2 CCT2	6.61e-04	55	107	3	18448421
Pubmed	Epithelial sodium channel genes Scnn1b and Scnn1g are closely linked on distal mouse chromosome 7.	RAF1 WNT11	7.15e-04	13	107	2	8575777
Pubmed	Enabling systematic interrogation of protein-protein interactions in live cells with a versatile ultra-high-throughput biosensor platform.	RAF1 AKT1S1	7.15e-04	13	107	2	26578655
Pubmed	Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.	RAF1 CASR TSC2 BCL6 SELENON	7.59e-04	231	107	5	21048031
Pubmed	TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer.	TSC2 AKT1S1	8.33e-04	14	107	2	28716898
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	RAF1 GBF1 CAND2 NUP85 WDR97 NUP210 GEMIN4 AFDN PPP6R2 TNPO3	8.60e-04	974	107	10	28675297
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	MYO1G MYH7B CCT2 RNF5 NUP210 MMS19 QARS1 TNPO3	8.92e-04	647	107	8	26618866
Pubmed	The DNA sequence, annotation and analysis of human chromosome 3.	CAND2 NUP210 PLXNA1	9.38e-04	62	107	3	16641997
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	RAF1 FBXL8 ALPK1 THAP4 RCBTB1 PRPF19	1.05e-03	372	107	6	22939624
Pubmed	The ubiquitin conjugating enzyme, UbcM2, engages in novel interactions with components of cullin-3 based E3 ligases.	RNF5 RCBTB1	1.09e-03	16	107	2	19256485
Pubmed	Identification of Greb1l as a genetic determinant of crisscross heart in mice showing torsion of the heart tube by shortage of progenitor cells.	WNT11 CACNA1H	1.09e-03	16	107	2	37852253
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	SIRPB1 FAM81A SPTBN4 KCNA4 IQSEC1	1.10e-03	251	107	5	27507650
Pubmed	Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.	WDR54 NUP210 DOCK7 MMS19 CTSB	1.22e-03	257	107	5	30945288
Pubmed	Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation.	ADAMTS5 ADAMTS20	1.24e-03	17	107	2	22183742
Pubmed	Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.	TNPO3 NOTCH4	1.24e-03	17	107	2	21779181
Pubmed	Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach.	RNF5 NOTCH4	1.39e-03	18	107	2	19143821
Pubmed	Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans.	BCL6 SAMD3	1.39e-03	18	107	2	23534349
Pubmed	Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.	ANKFY1 CAND2 GEMIN4 MMS19	1.40e-03	156	107	4	22952844
Cytoband	Ensembl 112 genes in cytogenetic band chr7p13	MYO1G POLM POLD2	2.65e-04	53	107	3	chr7p13
Cytoband	3p25.2	CAND2 IQSEC1	2.92e-04	11	107	2	3p25.2
Cytoband	Ensembl 112 genes in cytogenetic band chr3p25	RAF1 CAND2 NUP210 IQSEC1	4.92e-04	155	107	4	chr3p25
GeneFamily	Maestro heat like repeat containing	MROH5 MROH6	8.40e-04	11	72	2	636
GeneFamily	Endogenous ligands\|Minor histocompatibility antigens	MYO1G TRIM42 GEMIN4	1.10e-03	51	72	3	870
ToppCell	Adult-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Adult / Lineage, Cell type, age group and donor	ATP8A2 CASR CHST1 PLA2G4D KCNA4 ST18	4.15e-06	175	107	6	4db1a3c284488b3f6de7568363f176d74e2a4587
ToppCell	Adult-Epithelial-lung_neuroendocrine_cell_(PNEC)-D231\|Adult / Lineage, Cell type, age group and donor	ATP8A2 CASR CHST1 PLA2G4D KCNA4 ST18	4.15e-06	175	107	6	8d9f44a2633b71fb4d2b4a7d9530f954e07c4a18
ToppCell	21-Trachea-Epithelial-Neuroendocrine\|Trachea / Age, Tissue, Lineage and Cell class	MYH7B SLC26A9 PLA2G4D KCNA4 CACNA1H ST18	6.26e-06	188	107	6	e78d4f7a5d28c77503cb041ff585d13df4c88bd2
ToppCell	Tracheal-10x3prime_v2-Stromal-Mesofibroblastic\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CASR BCL6 AKT1S1 SPTBN4 KCNA4 SLC12A4	8.17e-06	197	107	6	d7cef7881abd807a679432766ced609a6efd1067
ToppCell	Tracheal-10x3prime_v2-Stromal-Mesofibroblastic-Mesothelia\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CASR BCL6 AKT1S1 SPTBN4 KCNA4 SLC12A4	8.17e-06	197	107	6	20a5958512bdb99daeb8f4d244df53e4f048f879
Drug	AC1Q6RZ6	HK1 HK3 AMDHD2 TGFA TXNIP QARS1	3.60e-07	60	106	6	CID000000609
Disease	lymphocyte measurement	MYO1G HK1 KCNA4 NUP210 IQSEC1	6.05e-05	117	104	5	EFO_0803546
Disease	immature platelet measurement	MYO1G CARMIL1 DDO SIRPB1 FAR2	6.56e-05	119	104	5	EFO_0803541
Disease	gestational trophoblastic neoplasm (is_implicated_in)	NLRP7 MEI1	7.35e-05	4	104	2	DOID:3590 (is_implicated_in)
Disease	Complete hydatidiform mole	NLRP7 MEI1	7.35e-05	4	104	2	C0678213
Disease	colorectal cancer (biomarker_via_orthology)	HK1 TXNIP	1.83e-04	6	104	2	DOID:9256 (biomarker_via_orthology)
Disease	renal cell carcinoma (implicated_via_orthology)	TSC2 TXNIP	1.83e-04	6	104	2	DOID:4450 (implicated_via_orthology)
Disease	platelet-to-lymphocyte ratio	MYO1G USP30 EXOSC9 RASA3 CARMIL1 ITGA4 FAR2	3.08e-04	363	104	7	EFO_0008446
Disease	non-alcoholic fatty liver disease	RAF1 HK1 IL36B KCNA4 DOCK7	4.74e-04	182	104	5	EFO_0003095
Disease	systemic lupus erythematosus	HIP1 CLIP2 CARMIL1 CASR DDO SIRPB1 RCBTB1 CTSB TNPO3 NOTCH4	5.29e-04	799	104	10	MONDO_0007915
Disease	immature platelet count	CARMIL1 DDO SIRPB1 FAR2	5.49e-04	106	104	4	EFO_0803544
Disease	hemolysis	HK1 KCNA4 ATAD2B	6.16e-04	47	104	3	EFO_0009473
Disease	immature platelet fraction	CARMIL1 DDO SIRPB1 FAR2	7.22e-04	114	104	4	EFO_0009187
Disease	platelet measurement	CARMIL1 DDO SIRPB1 KDM6B FAR2 DOCK7	8.92e-04	315	104	6	EFO_0005036
Disease	glucose homeostasis measurement, glucose effectiveness measurement	MYH7B BCL6	1.25e-03	15	104	2	EFO_0006833, EFO_0006896
Disease	basophil count	MYO1G HIP1 ITGA4 BCL6 ATAD2B CTSB NOTCH4	1.64e-03	483	104	7	EFO_0005090
Disease	cardiomyopathy (implicated_via_orthology)	RAF1 MYH7B CASR	2.04e-03	71	104	3	DOID:0050700 (implicated_via_orthology)
Disease	complement factor H-like 1 protein measurement	ATP8A2 FREM2	2.71e-03	22	104	2	EFO_0600092
Disease	systemic scleroderma	NUP85 TNPO3 NOTCH4	3.41e-03	85	104	3	EFO_0000717

Protein segments in the cluster

Peptide	Gene	Start	Entry
ELAADCHLSRIVQAT	AFDN	836	P55196
CLHDIALAHRAATAA	AKT1S1	61	Q96B36
FGAVEAISDRICIHT	CTSB	111	P07858
LRVGSCSDVVVDHAS	B4GALNT1	471	Q00973
ERSCAVIEDDGLHAA	ADAMTS5	391	Q9UNA0
ACILVAAGILATDTH	HTR3B	11	O95264
EVRCSTAAHAFKVAA	CASR	871	P41180
HAAVVELLLSCGVSA	ASB10	306	Q8WXI3
HVDFSSEVSTAVRIC	EFL1	96	Q7Z2Z2
VHRLAEESRTNACAS	CENPW	51	Q5EE01
DLERAEVAKATSHIC	CLIP2	376	Q9UDT6
VHREDVIVTCSGDAT	CD163L1	566	Q9NR16
VATDRSLALFSCVQH	EFCAB12	521	Q6NXP0
LDATRAAITQHCTDL	ATP8A2	736	Q9NTI2
HDTAVLITREDICSS	ADAMTS20	351	P59510
ARDCAAAAAIVFLVD	ALPK1	101	Q96QP1
FRVLDACSSEATHVV	POLM	56	Q9NP87
VAAATVLTFLDSHCE	GALNT16	201	Q8N428
HRAAHTEDINACTLT	RAF1	626	P04049
VVEIAACHSAHTSAA	RCBTB1	286	Q8NDN9
VSASAAHILGEVCRE	RASA3	316	Q14644
VARCDASIARLSAEH	FAM81A	136	Q8TBF8
EDIASTLVRHGCDAT	ANKFY1	701	Q9P2R3
VTLSDCSHFDLAVEV	NUP210	571	Q8TEM1
CAATVRFDDTLRHAV	FAR2	111	Q96K12
RVCATSILQDAESHH	KIAA0825	601	Q8IV33
SDCTDVLTRAGHAEV	MMS19	846	Q96T76
LAHSLRCSAEEATEG	PHKA1	931	P46020
RACTLKDTAHAIIAA	ATAD2B	1051	Q9ULI0
AESIDDALNCRSLHT	IQSEC1	251	Q6DN90
THVSLVALCFDRIAT	KIAA1109	1751	Q2LD37
TDSCSLEVSDRHHVV	FREM2	911	Q5SZK8
ADLTISHCAADVVRA	KDM6B	1131	O15054
ATEAATIDRHISESC	DDX59	46	Q5T1V6
EQCSAAHVSRVILAG	POLD2	231	P49005
IDAASIAAIVALCHF	EXOSC9	146	Q06265
SALAHAVQALRHDCD	MYH7B	1376	A7E2Y1
DASSVRAHDALVEVC	PLXNA1	926	Q9UIW2
RLHVCEVDSLSADVL	NUP85	171	Q9BW27
AVGHVDEERARSCLT	VEPH1	296	Q14D04
VLSALALEHARDVVC	MROH6	176	A6NGR9
TDCVGHDVVTLLRDA	HK1	626	P19367
AALAAVLSCLQHSRE	HK3	401	P52790
LSRDETLQVASAHCI	MEI1	291	Q5TIA1
GTALEAARLVSECVH	DDO	316	Q99489
ASCVQVVRAHESAVT	PRPF19	296	Q9UMS4
EELIVCSHEIAASTA	HIP1R	901	O75146
CSHEIAASTAQLVAA	HIP1R	906	O75146
VTLHLIACRDTEFSD	IL36B	41	Q9NZH7
EAAQCLVHSAALVAE	DOCK7	1706	Q96N67
RDVLEAVHAVCGAAS	FBXL8	121	Q96CD0
ATLCALEVRAAASAE	FBXL8	301	Q96CD0
ALSCHQVTEAVSAEA	BARX2	96	Q9UMQ3
IANVTRAAEVCSLHL	HYAL4	366	Q2M3T9
EVTCTGARDVRAAHT	BCAS4	196	Q8TDM0
DSCIQFTRHASDVLL	BCL6	6	P41182
SRAEEDLSITVHATC	ITGA4	736	P13612
SDISIAHVLAARADL	FAM98C	271	Q17RN3
KCVESLSFIVRDAAH	GBF1	1391	Q92538
SDRIVDEILDALSHC	CARMIL1	846	Q5VZK9
VAHAAATAAASLRLA	CACNA1H	591	O95180
HLAAACSTDLFVELA	CAND2	201	O75155
LVACAVSVHSAGDRS	DCAF15	251	Q66K64
VELCIAAILSHAARE	PPP6R2	391	O75170
IVARELSCLDVHLDS	PLA2G4D	156	Q86XP0
ARSHTCELVATFLNI	MROH5	806	Q6ZUA9
HVTAVCSQDASELVR	RTN4IP1	231	Q8WWV3
NLASLHVVDAALVDC	QARS1	716	P47897
HVVDAALVDCSVALA	QARS1	721	P47897
VCIAAGLRHAVAATA	SERGEF	156	Q9UGK8
HDTISLIDACSERAA	TRIM42	321	Q8IWZ5
LETAREAVVSVCGHL	RNF5	31	Q99942
VLHACSLRSVSAACE	TMEM150B	171	A6NC51
EAERLHVSATLACLT	SLC26A9	166	Q7LBE3
IIAVSSAHRAASLEA	MOCS2	136	O96007
DCVTALAALVAAFHV	SAMD3	461	Q8N6K7
FIESVVTAACQLARH	TAF12	91	Q16514
CSHEIAASTAQLVAA	HIP1	906	O00291
HAAKCTLISREDVEA	SKIDA1	76	Q1XH10
AERSLHDALCVLAQT	CCT2	386	P78371
FLSDSSVRILCDHVT	NLRP7	686	Q8WX94
GSTELLCSARDEHTA	STARD9	1401	Q9P2P6
LHAAVAADAREVCQL	NOTCH4	1671	Q99466
FIDTVRCTTAAHLAL	SLC12A4	811	Q9UP95
CSEDTHIAAAAAILN	ST18	566	O60284
HIAAAAAILNLSTRC	ST18	571	O60284
TVAAEACRERSHVAI	CHST1	191	O43916
ICVASASAHAANLVV	CLRN2	191	A0PK11
RACKVHLDSAVALAA	CLASRP	46	Q8N2M8
LVNTCAHRDDVVLTC	SIRPB1	316	O00241
RCEHADLLAVVAASQ	TGFA	81	P01135
LSHGTADVVLEACTD	TMEM94	701	Q12767
EHLNSSLESRDVCAS	STKLD1	466	Q8NE28
AECLRSCHQEATSVA	PLEKHG4B	546	Q96PX9
AHCLARAEVSTAAQT	WDR97	911	A6NE52
AAAAAVRVCARHAEA	SELENON	41	Q9NZV5
GDLVVSLTECSAHAA	TLNRD1	116	Q9H1K6
CEDARLHVSSTADAL	SPTBN4	1931	Q9H254
DAEVVCSGHTEARLV	SCART1	221	Q4G0T1
TVCDAALDLATAHVV	SCART1	251	Q4G0T1
HLVADSHESTQRCVA	PSME4	1366	Q14997
IASTTLDHRDANCSV	TNPO3	781	Q9Y5L0
ALSAAAISHAIARAC	WNT11	116	O96014
AISHAIARACTSGDL	WNT11	121	O96014
HHFISSESVRDVVCD	USP30	271	Q70CQ3
SIHADFENTCSRIVV	TXNIP	196	Q9H3M7
EALESAHVCLINATA	NAE1	26	Q13564
QELCIASHSIARISF	THAP4	516	Q8WY91
AAEAFRCRSISVSEH	TSC2	971	P49815
HARAICALDLASEVG	WDR54	251	Q9H977
IVEALREISSAAAHS	GEMIN4	46	P57678
ERLAHSRAAAAAAVA	KCNA4	31	P22459
HRGILAVLDEACSSA	MYO1G	461	B0I1T2
CVSLGHSVADLRAAE	AMDHD2	206	Q9Y303