Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionandrosterone dehydrogenase (B-specific) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.00e-0842394GO:0047042
GeneOntologyMolecularFunctionketoreductase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.00e-0842394GO:0045703
GeneOntologyMolecularFunctionchlordecone reductase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.00e-0842394GO:0047743
GeneOntologyMolecularFunctiontrans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.91e-0852394GO:0047115
GeneOntologyMolecularFunction15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.91e-0852394GO:0047020
GeneOntologyMolecularFunction17-beta-ketosteroid reductase (NADPH) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.91e-0852394GO:0072555
GeneOntologyMolecularFunction17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.91e-0852394GO:0047006
GeneOntologyMolecularFunctionlithocholic acid binding

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.91e-0852394GO:1902121
GeneOntologyMolecularFunctionketosteroid monooxygenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.91e-0852394GO:0047086
GeneOntologyMolecularFunctionDelta4-3-oxosteroid 5beta-reductase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.91e-0852394GO:0047787
GeneOntologyMolecularFunctiongeranylgeranyl reductase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.95e-0762394GO:0045550
GeneOntologyMolecularFunction17-beta-hydroxysteroid dehydrogenase (NADP+) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.81e-0772394GO:0072582
GeneOntologyMolecularFunction5alpha-androstane-3beta,17beta-diol dehydrogenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.35e-0682394GO:0047024
GeneOntologyMolecularFunctionandrosterone dehydrogenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.35e-0682394GO:0047023
GeneOntologyMolecularFunctionenone reductase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.35e-0682394GO:0035671
GeneOntologyMolecularFunctionandrostan-3-alpha,17-beta-diol dehydrogenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.41e-0692394GO:0047044
GeneOntologyMolecularFunctionNADP+ binding

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.41e-0692394GO:0070401
GeneOntologyMolecularFunctiontestosterone 17-beta-dehydrogenase (NADP+) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.97e-06102394GO:0047045
GeneOntologyMolecularFunctionbile acid binding

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.97e-06102394GO:0032052
GeneOntologyMolecularFunctionNADPH binding

AKR1C4 AKR1C1 AKR1C2 KCNAB1 AKR1C3

1.26e-05262395GO:0070402
GeneOntologyMolecularFunctionnuclear localization sequence binding

KPNB1 KPNA3 KPNA5 NUP98 IPO4

1.53e-05272395GO:0008139
GeneOntologyMolecularFunctionaldose reductase (NADPH) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.82e-05142394GO:0004032
GeneOntologyMolecularFunctionretinal dehydrogenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.82e-05142394GO:0001758
GeneOntologyMolecularFunctionaldo-keto reductase (NADPH) activity

AKR1C4 AKR1C1 AKR1C2 KCNAB1 AKR1C3

3.64e-05322395GO:0004033
GeneOntologyMolecularFunctionestradiol 17-beta-dehydrogenase [NAD(P)+] activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.34e-05202394GO:0004303
GeneOntologyMolecularFunctionnuclear import signal receptor activity

KPNB1 KPNA3 KPNA5 IPO4

8.34e-05202394GO:0061608
GeneOntologyMolecularFunctionmacrophage colony-stimulating factor receptor activity

MST1R CSF1R

1.43e-0422392GO:0005011
GeneOntologyMolecularFunctionsulfonylurea receptor activity

ABCC8 ABCC9

1.43e-0422392GO:0008281
GeneOntologyMolecularFunctionall-trans-retinol dehydrogenase (NAD+) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.76e-04242394GO:0004745
GeneOntologyMolecularFunctionalcohol dehydrogenase (NAD+) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.43e-04262394GO:0004022
GeneOntologyMolecularFunctiontestosterone dehydrogenase [NAD(P)+] activity

AKR1C4 AKR1C1 AKR1C3

2.60e-04112393GO:0030283
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

AKR1C4 AKR1C1 AKR1C2 ALDH18A1 AKR1C3

2.65e-04482395GO:0016620
GeneOntologyMolecularFunctionalcohol dehydrogenase (NADP+) activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.83e-04272394GO:0008106
GeneOntologyMolecularFunctionsignal sequence binding

KPNB1 KPNA3 KPNA5 NUP98 IPO4

3.53e-04512395GO:0005048
GeneOntologyMolecularFunctionalcohol dehydrogenase [NAD(P)+] activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.29e-04302394GO:0018455
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors

AKR1C4 AKR1C1 AKR1C2 ALDH18A1 AKR1C3

5.47e-04562395GO:0016903
GeneOntologyMolecularFunctionnucleocytoplasmic carrier activity

KPNB1 KPNA3 KPNA5 IPO4

5.53e-04322394GO:0140142
GeneOntologyMolecularFunctionsteroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.23e-04332394GO:0033764
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.00e-04342394GO:0016628
GeneOntologyMolecularFunctionoxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

AKR1C4 NDUFA2 AKR1C1 AKR1C2 AKR1C3

7.53e-04602395GO:0016655
GeneOntologyMolecularFunctioncatalytic activity, acting on a nucleic acid

ALKBH4 DIS3L2 SRCAP LCMT2 DQX1 PTRH1 XRN1 ASCC3 DSCC1 SLFN12 CHD1L HELQ METTL25B SLFN13 N4BP2 MARF1 TREX2 SLFN11

8.01e-0464523918GO:0140640
GeneOntologyMolecularFunctionindanol dehydrogenase activity

AKR1C1 AKR1C2

8.43e-0442392GO:0047718
GeneOntologyMolecularFunctionNADP binding

AKR1C4 AKR1C1 AKR1C2 KCNAB1 AKR1C3

8.75e-04622395GO:0050661
GeneOntologyMolecularFunctionsteroid dehydrogenase activity

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.18e-03392394GO:0016229
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.30e-03402394GO:0016709
GeneOntologyMolecularFunctionvoltage-gated channel activity

TPCN1 ABCC8 KCNAB1 CACNA1H GRIN3B CACNB4 ABCC9 KCNV1

1.72e-031842398GO:0022832
GeneOntologyMolecularFunctionhydrolase activity, acting on ester bonds

DIS3L2 INPP1 HNF4A PTRH1 XRN1 PNPLA2 PPM1D SLFN12 CASR IDS PPP2R1A ARSD SLFN13 NT5DC2 N4BP2 MARF1 TREX2 SLFN11 ABHD12 PHLPP2

1.76e-0380723920GO:0016788
GeneOntologyMolecularFunctionmonocarboxylic acid binding

AKR1C4 HNF4A AKR1C1 AKR1C2 UGT2B17 AKR1C3

1.82e-031072396GO:0033293
GeneOntologyMolecularFunctionATP-activated inward rectifier potassium channel activity

ABCC8 ABCC9

2.07e-0362392GO:0015272
GeneOntologyMolecularFunctionhelicase activity

SRCAP DQX1 ASCC3 DSCC1 CHD1L HELQ SLFN11

2.98e-031582397GO:0004386
GeneOntologyMolecularFunctionATP-dependent activity

NUBP1 SRCAP DNAH14 DQX1 ABCC8 ASCC3 DSCC1 ABCC1 HSPA4L RNF213 ABCC9 CHD1L HELQ DNAH1 SLFN13 SLFN11

3.07e-0361423916GO:0140657
GeneOntologyBiologicalProcessresponse to jasmonic acid

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.64e-0842354GO:0009753
GeneOntologyBiologicalProcessprogesterone catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.64e-0842354GO:0006709
GeneOntologyBiologicalProcessC21-steroid hormone catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.64e-0842354GO:0008208
GeneOntologyBiologicalProcesscellular response to jasmonic acid stimulus

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.64e-0842354GO:0071395
GeneOntologyBiologicalProcesssesquiterpenoid catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.14e-0852354GO:0016107
GeneOntologyBiologicalProcessolefinic compound catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.14e-0852354GO:0120256
GeneOntologyBiologicalProcessfarnesol metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.14e-0852354GO:0016487
GeneOntologyBiologicalProcessfarnesol catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.14e-0852354GO:0016488
GeneOntologyBiologicalProcessnegative regulation of isoprenoid metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.14e-0852354GO:0045827
GeneOntologyBiologicalProcessnegative regulation of retinoic acid biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.14e-0852354GO:1900053
GeneOntologyBiologicalProcesssesquiterpenoid metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.42e-0762354GO:0006714
GeneOntologyBiologicalProcesspolyprenol catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.42e-0762354GO:0016095
GeneOntologyBiologicalProcesscell cycle process

ALKBH4 DPF1 DIS3L2 PIDD1 NUBP1 POGZ CUL7 MDM2 BIRC6 USP19 PNMA5 PTTG3P RPTOR CRLF3 FBXO7 FES DSCC1 KPNB1 CACNB4 SEPTIN5 PPM1D GTSE1 SLFN12 MEI1 SPAG5 TUBGCP6 PPP2R1A LIMK2 PBRM1 CSF1R TK1 MARF1 SMARCB1 CCAR2 SLFN11 PRKDC CKAP2 DOT1L ANKFN1

3.84e-07144123539GO:0022402
GeneOntologyBiologicalProcessresponse to prostaglandin D

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.60e-0772354GO:0071798
GeneOntologyBiologicalProcesscellular response to prostaglandin D stimulus

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.60e-0772354GO:0071799
GeneOntologyBiologicalProcessregulation of retinoic acid biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.60e-0772354GO:1900052
GeneOntologyBiologicalProcessregulation of cell cycle G1/S phase transition

DPF1 PIDD1 MDM2 RPTOR CRLF3 FBXO7 CACNB4 GTSE1 SLFN12 PBRM1 CSF1R SMARCB1 SLFN11 PRKDC

9.54e-0724623514GO:1902806
GeneOntologyBiologicalProcessregulation of G1/S transition of mitotic cell cycle

DPF1 PIDD1 MDM2 RPTOR CRLF3 FBXO7 CACNB4 GTSE1 SLFN12 PBRM1 SMARCB1 SLFN11 PRKDC

1.08e-0621323513GO:2000045
GeneOntologyBiologicalProcessnegative regulation of G1/S transition of mitotic cell cycle

PIDD1 MDM2 CRLF3 FBXO7 CACNB4 GTSE1 SLFN12 SLFN11 PRKDC

1.81e-06982359GO:2000134
GeneOntologyBiologicalProcessdaunorubicin metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.98e-0692354GO:0044597
GeneOntologyBiologicalProcessregulation of isoprenoid metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.27e-06102354GO:0019747
GeneOntologyBiologicalProcessdoxorubicin metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.27e-06102354GO:0044598
GeneOntologyBiologicalProcessnegative regulation of vitamin metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.27e-06102354GO:0046137
GeneOntologyBiologicalProcesspolyketide metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.27e-06102354GO:0030638
GeneOntologyBiologicalProcessaminoglycoside antibiotic metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.27e-06102354GO:0030647
GeneOntologyBiologicalProcesstertiary alcohol metabolic process

AKR1C4 AKR1C1 AKR1C2 CACNA1H AKR1C3

4.14e-06222355GO:1902644
GeneOntologyBiologicalProcessnegative regulation of cell cycle G1/S phase transition

PIDD1 MDM2 CRLF3 FBXO7 CACNB4 GTSE1 SLFN12 SLFN11 PRKDC

4.40e-061092359GO:1902807
GeneOntologyBiologicalProcessregulation of testosterone biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.09e-06112354GO:2000224
GeneOntologyBiologicalProcessterpenoid catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.09e-06112354GO:0016115
GeneOntologyBiologicalProcesscell cycle G1/S phase transition

DPF1 PIDD1 MDM2 RPTOR CRLF3 FBXO7 CACNB4 GTSE1 SLFN12 PBRM1 CSF1R SMARCB1 SLFN11 PRKDC

1.20e-0530623514GO:0044843
GeneOntologyBiologicalProcessDNA damage response

DPF1 SUPT20HL1 PIDD1 SUPT20HL2 POGZ MDM2 PTTG3P HROB RPTOR AP5Z1 ASCC3 BRAT1 SUPT20H PPM1D GTSE1 CHD1L HELQ FAAP100 PBRM1 MARF1 SMARCB1 CCAR2 TREX2 SLFN11 PRKDC HDAC10 DOT1L

1.43e-0595923527GO:0006974
GeneOntologyBiologicalProcessG1/S transition of mitotic cell cycle

DPF1 PIDD1 MDM2 RPTOR CRLF3 FBXO7 CACNB4 GTSE1 SLFN12 PBRM1 SMARCB1 SLFN11 PRKDC

1.49e-0527123513GO:0000082
GeneOntologyBiologicalProcessretinoic acid biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.50e-05142354GO:0002138
GeneOntologyBiologicalProcessisoprenoid catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.50e-05142354GO:0008300
GeneOntologyBiologicalProcessditerpenoid biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.03e-05152354GO:0016102
GeneOntologyBiologicalProcessrRNA catabolic process

XRN1 SLFN12 SLFN13 SLFN11

2.03e-05152354GO:0016075
GeneOntologyBiologicalProcesstestosterone biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.68e-05162354GO:0061370
GeneOntologyBiologicalProcessnegative regulation of hormone metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.68e-05162354GO:0032351
GeneOntologyBiologicalProcessregulation of vitamin metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.43e-05182354GO:0030656
GeneOntologyBiologicalProcessolefinic compound biosynthetic process

AKR1C4 AKR1C1 AKR1C2 CACNA1H AKR1C3

4.52e-05352355GO:0120255
GeneOntologyBiologicalProcesscellular response to nutrient levels

LRRK2 MDM2 MAP3K5 RPTOR ABCC8 FES SIK2 GCN1 COMT PPM1D CASR PRKAG3

5.00e-0526223512GO:0031669
GeneOntologyBiologicalProcessnegative regulation of lipid biosynthetic process

AKR1C4 AKR1C1 AKR1C2 SIK2 SCAP MALRD1 AKR1C3

8.19e-05912357GO:0051055
GeneOntologyBiologicalProcesshormone catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.44e-05212354GO:0042447
GeneOntologyBiologicalProcessterpenoid biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.44e-05212354GO:0016114
GeneOntologyBiologicalProcessregulation of retinoic acid receptor signaling pathway

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.44e-05212354GO:0048385
GeneOntologyBiologicalProcessketone catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.44e-05212354GO:0042182
GeneOntologyBiologicalProcessretinal metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.44e-05212354GO:0042574
GeneOntologyBiologicalProcessmitotic cell cycle

DPF1 DIS3L2 PIDD1 CUL7 MDM2 HNF4A RPTOR CRLF3 FBXO7 NLE1 KPNB1 CACNB4 TTC28 PPM1D GTSE1 SLFN12 SPAG5 TUBGCP6 PPP2R1A PBRM1 TK1 SMARCB1 SLFN11 PRKDC CKAP2 ANKFN1

9.86e-05101423526GO:0000278
GeneOntologyBiologicalProcessglycoside metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.02e-04222354GO:0016137
GeneOntologyBiologicalProcessprogesterone metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.02e-04222354GO:0042448
GeneOntologyBiologicalProcessparturition

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.02e-04222354GO:0007567
GeneOntologyBiologicalProcessglycosyl compound metabolic process

AKR1C4 ADA2 LCMT2 AKR1C1 AKR1C2 TK1 AKR1C3

1.15e-04962357GO:1901657
GeneOntologyBiologicalProcesscellular response to prostaglandin stimulus

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.23e-04232354GO:0071379
GeneOntologyBiologicalProcessprimary alcohol catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.23e-04232354GO:0034310
GeneOntologyBiologicalProcessregulation of RNA splicing

SUPT20HL1 SUPT20HL2 AKR1C4 YTHDC1 AKR1C1 AKR1C2 SUPT20H NUP98 PRX AKR1C3

1.37e-0420723510GO:0043484
GeneOntologyBiologicalProcessregulation of small molecule metabolic process

SUPT20HL1 SUPT20HL2 AKR1C4 HNF4A AKR1C1 AKR1C2 RPTOR SIK2 SUPT20H COMT SLC4A1 PRKAG3 SCAP MALRD1 AKR1C3

1.46e-0443423515GO:0062012
GeneOntologyBiologicalProcessC21-steroid hormone metabolic process

AKR1C4 AKR1C1 AKR1C2 CACNA1H AKR1C3

1.55e-04452355GO:0008207
GeneOntologyBiologicalProcessDNA repair

DPF1 SUPT20HL1 SUPT20HL2 POGZ PTTG3P HROB AP5Z1 ASCC3 SUPT20H CHD1L HELQ FAAP100 PBRM1 MARF1 SMARCB1 TREX2 PRKDC HDAC10 DOT1L

1.69e-0464823519GO:0006281
GeneOntologyBiologicalProcessregulation of ketone biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.02e-04262354GO:0010566
GeneOntologyBiologicalProcessDNA metabolic process

DPF1 SUPT20HL1 SUPT20HL2 POGZ PTTG3P HROB AP5Z1 CIZ1 XRN1 ASCC3 DSCC1 SUPT20H SMG5 CHD1L HELQ FAAP100 PBRM1 TK1 N4BP2 MARF1 SMARCB1 TREX2 SLFN11 PRKDC HDAC10 DOT1L

2.70e-04108123526GO:0006259
GeneOntologyBiologicalProcessnegative regulation of mRNA splicing, via spliceosome

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.71e-04282354GO:0048025
GeneOntologyBiologicalProcessregulation of cell cycle process

DPF1 PIDD1 NUBP1 CUL7 MDM2 BIRC6 USP19 RPTOR CRLF3 FBXO7 CACNB4 GTSE1 SLFN12 SPAG5 PPP2R1A PBRM1 CSF1R SMARCB1 CCAR2 SLFN11 PRKDC DOT1L

2.80e-0484523522GO:0010564
GeneOntologyBiologicalProcessregulation of cell cycle phase transition

DPF1 PIDD1 MDM2 RPTOR CRLF3 FBXO7 CACNB4 GTSE1 SLFN12 PBRM1 CSF1R SMARCB1 CCAR2 SLFN11 PRKDC DOT1L

3.01e-0451623516GO:1901987
GeneOntologyBiologicalProcesspolyprenol metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.12e-04292354GO:0016093
GeneOntologyBiologicalProcessnegative regulation of mRNA processing

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.12e-04292354GO:0050686
GeneOntologyBiologicalProcessnegative regulation of small molecule metabolic process

AKR1C4 AKR1C1 AKR1C2 SIK2 SLC4A1 SCAP MALRD1 AKR1C3

3.16e-041492358GO:0062014
GeneOntologyBiologicalProcessmitotic cell cycle process

DPF1 DIS3L2 PIDD1 CUL7 MDM2 RPTOR CRLF3 FBXO7 KPNB1 CACNB4 PPM1D GTSE1 SLFN12 SPAG5 PPP2R1A PBRM1 TK1 SMARCB1 SLFN11 PRKDC CKAP2 ANKFN1

3.24e-0485423522GO:1903047
GeneOntologyBiologicalProcesschromosome organization

DPF1 DIS3L2 POGZ PTTG3P XRN1 ASCC3 DSCC1 KPNB1 NUP98 SMG5 CHD1L MEI1 HELQ SPAG5 PPP2R1A PBRM1 SMARCB1 PRKDC DOT1L

3.46e-0468623519GO:0051276
GeneOntologyBiologicalProcessregulation of platelet formation

CSF1R PRKDC

3.85e-0432352GO:1905219
GeneOntologyBiologicalProcessnegative regulation of mitotic cell cycle

PIDD1 MDM2 HNF4A CRLF3 FBXO7 NLE1 CACNB4 GTSE1 SLFN12 SLFN11 PRKDC

4.12e-0428223511GO:0045930
GeneOntologyBiologicalProcessprostaglandin metabolic process

AKR1C4 AKR1C1 AKR1C2 COMT AKR1C3

4.38e-04562355GO:0006693
GeneOntologyBiologicalProcesspositive regulation of endothelial cell apoptotic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.60e-04322354GO:2000353
GeneOntologyBiologicalProcesspositive regulation of gluconeogenesis

SUPT20HL1 SUPT20HL2 HNF4A SUPT20H

4.60e-04322354GO:0045722
GeneOntologyBiologicalProcessprostanoid metabolic process

AKR1C4 AKR1C1 AKR1C2 COMT AKR1C3

4.76e-04572355GO:0006692
GeneOntologyBiologicalProcessketone biosynthetic process

AKR1C4 AKR1C1 AKR1C2 CACNA1H AKR1C3

4.76e-04572355GO:0042181
GeneOntologyBiologicalProcessregulation of mitotic cell cycle

DPF1 PIDD1 CUL7 MDM2 HNF4A RPTOR CRLF3 FBXO7 NLE1 CACNB4 TTC28 GTSE1 SLFN12 PBRM1 SMARCB1 SLFN11 PRKDC

4.91e-0459423517GO:0007346
GeneOntologyBiologicalProcessnegative regulation of RNA splicing

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.18e-04332354GO:0033119
GeneOntologyBiologicalProcessmitotic G1 DNA damage checkpoint signaling

PIDD1 MDM2 GTSE1 PRKDC

5.82e-04342354GO:0031571
GeneOntologyBiologicalProcesssteroid catabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.82e-04342354GO:0006706
GeneOntologyBiologicalProcessmitotic G1/S transition checkpoint signaling

PIDD1 MDM2 GTSE1 PRKDC

5.82e-04342354GO:0044819
GeneOntologyBiologicalProcessrescue of stalled ribosome

PTRH1 ASCC3 GCN1 TCF25

5.82e-04342354GO:0072344
GeneOntologyBiologicalProcessresponse to prostaglandin

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.27e-04362354GO:0034694
GeneOntologyBiologicalProcessisoprenoid biosynthetic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.27e-04362354GO:0008299
GeneOntologyBiologicalProcessregulation of mitotic cell cycle phase transition

DPF1 PIDD1 MDM2 RPTOR CRLF3 FBXO7 CACNB4 GTSE1 SLFN12 PBRM1 SMARCB1 SLFN11 PRKDC

7.49e-0440223513GO:1901990
GeneOntologyBiologicalProcessresponse to nutrient levels

LRRK2 MDM2 MAP3K5 RPTOR ABCC8 FES SIK2 GCN1 COMT PPM1D OR4M1 CASR CUBN PRKAG3 OR4M2 SCAP

8.16e-0456623516GO:0031667
GeneOntologyBiologicalProcesstranslational elongation

PTRH1 ASCC3 GCN1 EEF1A1 EEF1A1P5 TCF25

8.55e-04972356GO:0006414
GeneOntologyBiologicalProcesscell cycle phase transition

DPF1 PIDD1 MDM2 RPTOR CRLF3 FBXO7 CACNB4 PPM1D GTSE1 SLFN12 PBRM1 CSF1R SMARCB1 CCAR2 SLFN11 PRKDC DOT1L

8.94e-0462723517GO:0044770
GeneOntologyBiologicalProcessretinoic acid receptor signaling pathway

AKR1C4 AKR1C1 AKR1C2 AKR1C3

8.94e-04382354GO:0048384
GeneOntologyBiologicalProcessnegative regulation of cell cycle phase transition

PIDD1 MDM2 CRLF3 FBXO7 CACNB4 GTSE1 SLFN12 CCAR2 SLFN11 PRKDC DOT1L

9.24e-0431123511GO:1901988
GeneOntologyBiologicalProcessnegative regulation of cell cycle

PIDD1 NUBP1 MDM2 HNF4A CRLF3 FBXO7 NLE1 CACNB4 GTSE1 SLFN12 CCAR2 SLFN11 PRKDC DOT1L

9.28e-0446423514GO:0045786
GeneOntologyBiologicalProcessnegative regulation of mitotic cell cycle phase transition

PIDD1 MDM2 CRLF3 FBXO7 CACNB4 GTSE1 SLFN12 SLFN11 PRKDC

9.50e-042192359GO:1901991
GeneOntologyBiologicalProcessprotein localization to nucleus

LRRK2 MDM2 HNF4A CIZ1 KPNB1 KPNA3 KPNA5 CACNB4 NUP98 IPO4 TESK1 LIMK2

9.62e-0436223512GO:0034504
GeneOntologyBiologicalProcessnegative regulation of cell cycle process

PIDD1 NUBP1 MDM2 CRLF3 FBXO7 CACNB4 GTSE1 SLFN12 CCAR2 SLFN11 PRKDC DOT1L

9.62e-0436223512GO:0010948
GeneOntologyBiologicalProcessretinoic acid metabolic process

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.09e-03402354GO:0042573
GeneOntologyBiologicalProcessresponse to estrogen

AKR1C4 MDM2 AKR1C1 AKR1C2 ABCC9 AKR1C3

1.17e-031032356GO:0043627
GeneOntologyBiologicalProcessxenobiotic metabolic process

AKR1C4 HNF4A AKR1C1 AKR1C2 UGT2B17 ABCC1 AKR1C3

1.18e-031412357GO:0006805
GeneOntologyBiologicalProcessicosanoid metabolic process

AKR1C4 AKR1C1 AKR1C2 ABCC1 COMT AKR1C3 ABHD12

1.23e-031422357GO:0006690
GeneOntologyBiologicalProcessribosome disassembly

PTRH1 ASCC3 GCN1 TCF25

1.31e-03422354GO:0032790
GeneOntologyBiologicalProcesscellular response to fatty acid

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.31e-03422354GO:0071398
GeneOntologyBiologicalProcessregulation of steroid biosynthetic process

AKR1C4 AKR1C1 AKR1C2 SCAP MALRD1 AKR1C3

1.36e-031062356GO:0050810
MousePhenohypermyelination

AKR1C4 AKR1C1 AKR1C2 CSF1R AKR1C3

1.95e-07111915MP:0010050
MousePhenoabnormal gestational length

AKR1C4 AKR1C1 AKR1C2 COMT AKR1C3

3.35e-06181915MP:0002292
MousePhenoparturition failure

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.65e-06101914MP:0012010
MousePhenoincreased oligodendrocyte number

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.19e-05131914MP:0010160
MousePhenoincreased circulating progesterone level

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.10e-05151914MP:0005186
MousePhenolong stride length

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.10e-05151914MP:0010540
MousePhenolong gestation period

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.10e-05151914MP:0002293
MousePhenoprolonged diestrus

AKR1C4 AKR1C1 AKR1C2 CSF1R AKR1C3

4.88e-05301915MP:0009011
MousePhenoabnormal diestrus

AKR1C4 AKR1C1 AKR1C2 CSF1R AKR1C3

1.05e-04351915MP:0009010
MousePhenoabnormal left-right axis symmetry of the somites

SUPT20HL1 SUPT20HL2 SUPT20H

1.34e-0481913MP:0005224
MousePhenodysmyelination

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.38e-04201914MP:0013438
MousePhenoenhanced coordination

LRRK2 AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.57e-04381915MP:0003858
MousePhenoprolonged estrous cycle

AKR1C4 AKR1C1 AKR1C2 CSF1R AKR1C3

1.78e-04391915MP:0009006
DomainARM-like

ARMC3 LRRK2 PSMD2 CUL7 AP2A1 RPTOR AP5Z1 AP1G2 BRAT1 GCN1 KPNB1 KPNA3 KPNA5 HEATR4 NBEA HEATR5A IPO4 MEI1 SPAG6 RSPRY1 PPP2R1A MROH6 PRKDC

3.39e-1327023023IPR011989
DomainARM-type_fold

ARMC3 LRRK2 INTS1 PSMD2 CUL7 AP2A1 PIK3CD RPTOR AP1G2 BRAT1 GCN1 UNC79 KPNB1 KPNA3 KPNA5 HEATR4 NBEA HEATR5A IPO4 MEI1 SPAG6 RSPRY1 PPP2R1A MROH6 PRKDC

7.83e-1333923025IPR016024
Domain-

ARMC3 LRRK2 PSMD2 CUL7 AP2A1 RPTOR AP5Z1 AP1G2 BRAT1 GCN1 KPNB1 KPNA3 KPNA5 HEATR4 HEATR5A IPO4 SPAG6 PPP2R1A MROH6 PRKDC

4.50e-12222230201.25.10.10
DomainHEAT

RPTOR BRAT1 GCN1 KPNB1 HEATR4 IPO4 SPAG6 PPP2R1A PRKDC

6.15e-09482309PF02985
DomainHEAT

RPTOR BRAT1 GCN1 KPNB1 HEATR4 IPO4 SPAG6 PPP2R1A PRKDC

3.51e-08582309IPR000357
Domain-

AKR1C4 AKR1C1 AKR1C2 KCNAB1 AKR1C3

1.06e-061623053.20.20.100
DomainNADP_OxRdtase_dom

AKR1C4 AKR1C1 AKR1C2 KCNAB1 AKR1C3

1.49e-06172305IPR023210
DomainAldo_ket_red

AKR1C4 AKR1C1 AKR1C2 KCNAB1 AKR1C3

1.49e-06172305PF00248
DomainAldo/ket_red/Kv-b

AKR1C4 AKR1C1 AKR1C2 KCNAB1 AKR1C3

1.49e-06172305IPR001395
DomainHEAT_REPEAT

BRAT1 GCN1 KPNB1 HEATR4 HEATR5A IPO4 PPP2R1A PRKDC

2.29e-06702308PS50077
DomainALDOKETO_REDUCTASE_1

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.44e-06102304PS00798
DomainALDOKETO_REDUCTASE_2

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.44e-06102304PS00062
DomainALDOKETO_REDUCTASE_3

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.44e-06102304PS00063
DomainAldo/ket_reductase_CS

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.44e-06102304IPR018170
DomainAldo/keto_reductase

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.44e-06102304IPR020471
DomainARM

ARMC3 GCN1 KPNB1 KPNA3 KPNA5 SPAG6

8.84e-06402306SM00185
DomainArmadillo

ARMC3 GCN1 KPNB1 KPNA3 KPNA5 SPAG6

2.30e-05472306IPR000225
DomainArm

ARMC3 KPNB1 KPNA3 KPNA5 SPAG6

3.55e-05312305PF00514
DomainHEAT_type_2

GCN1 KPNB1 IPO4 PPP2R1A

4.70e-05172304IPR021133
DomainAlbA_2

SLFN12 SLFN13 SLFN11

6.22e-0572303PF04326
DomainSchlafen

SLFN12 SLFN13 SLFN11

6.22e-0572303IPR029684
DomainSchlafen_AAA_dom

SLFN12 SLFN13 SLFN11

6.22e-0572303IPR007421
DomainAlpha_adaptinC2

GGA3 AP2A1 AP1G2

1.47e-0492303PF02883
DomainClathrin_a/b/g-adaptin_app_Ig

GGA3 AP2A1 AP1G2

1.47e-0492303IPR008152
DomainAlpha_adaptinC2

GGA3 AP2A1 AP1G2

1.47e-0492303SM00809
DomainSpt20

SUPT20HL2 SUPT20H

1.51e-0422302IPR021950
DomainSulphorea_rcpt

ABCC8 ABCC9

1.51e-0422302IPR000388
DomainSpt20

SUPT20HL2 SUPT20H

1.51e-0422302PF12090
DomainAT_hook

SRCAP FAM171B BAZ2A DOT1L

3.15e-04272304SM00384
DomainAT_hook_DNA-bd_motif

SRCAP FAM171B BAZ2A DOT1L

3.15e-04272304IPR017956
DomainCoatomer/clathrin_app_Ig-like

GGA3 AP2A1 AP1G2

3.74e-04122303IPR013041
DomainDUF2075

SLFN13 SLFN11

4.49e-0432302PF09848
DomainDUF2075

SLFN13 SLFN11

4.49e-0432302IPR018647
DomainNeurofascin/L1/NrCAM_C

CHL1 NRCAM

8.91e-0442302IPR026966
DomainBravo_FIGEY

CHL1 NRCAM

8.91e-0442302PF13882
Domain-

LRRK2 NUBP1 SRCAP DNAH14 GSPT2 DQX1 ABCC8 ASCC3 ABCC1 CACNB4 SEPTIN5 RNF213 ABCC9 CHD1L HELQ EEF1A1 DNAH1 SLFN13 N4BP2 SLFN11

9.54e-04746230203.40.50.300
DomainARM_REPEAT

ARMC3 KPNA3 KPNA5 SPAG6

1.45e-03402304PS50176
DomainNUT

NUTM2A NUTM2B

1.47e-0352302IPR024310
DomainNUT_N

NUTM2A NUTM2B

1.47e-0352302IPR024309
DomainGAE

GGA3 AP1G2

1.47e-0352302PS50180
DomainNUT

NUTM2A NUTM2B

1.47e-0352302PF12881
Domain-

CHL1 LRRC24 SIRPB2 VSTM4 CRLF3 ASTN2 PLXNA3 NRCAM RELB VSIG10 MST1R TGM3 CSF1R SIGLEC6 NCAN SIGLEC1 FNDC8 ANKFN1

1.49e-03663230182.60.40.10
PathwayWP_BENZOAPYRENE_METABOLISM

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.02e-0691624M39344
PathwayKEGG_MEDICUS_ENV_FACTOR_METALS_TO_KEAP1_NRF2_SIGNALIG_PATHWAY

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.02e-0691624M47817
PathwayKEGG_MEDICUS_ENV_FACTOR_BENZO_A_PYRENRE_TO_CYP_MEDIATED_METABOLISM

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.21e-06111624M47812
PathwayREACTOME_PREDNISONE_ADME

AKR1C4 AKR1C1 AKR1C2 UGT2B17 AKR1C3

5.36e-06231625MM16639
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.11e-05131624MM14747
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.11e-05131624M17842
PathwayWP_GLUCOCORTICOID_BIOSYNTHESIS

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-05141624M46449
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-05141624M27074
PathwayWP_MINERALOCORTICOID_BIOSYNTHESIS

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-05141624M46453
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-05141624MM14748
PathwayREACTOME_SYNTHESIS_OF_PROSTAGLANDINS_PG_AND_THROMBOXANES_TX

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.08e-05151624MM14870
PathwayKEGG_STEROID_HORMONE_BIOSYNTHESIS

AKR1C4 AKR1C1 AKR1C2 UGT2B17 COMT AKR1C3

3.82e-05551626M14933
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.25e-04231624MM14741
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.25e-04231624M1926
PathwayWP_THERMOGENESIS

DPF1 RPS6KB2 MAP3K5 RPTOR PNPLA2 PRKAG3 SMARCB1

2.45e-041081627M39746
PathwayREACTOME_RA_BIOSYNTHESIS_PATHWAY

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.77e-04281624MM15188
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

VWA5B2 ALKBH4 LRRC24 PPRC1 INTS1 SRCAP BIRC6 MAP3K5 GGA3 TPCN1 ZCCHC14 AP2A1 PIK3CD RPTOR MCM3AP AP1G2 NLE1 CACNA1H BRAT1 GCN1 SMURF2 PLXNA3 DPH2 PNPLA2 GTSE1 HECTD4 RELB SMG5 HES2 TESK1 FAAP100 MST1R SCAP MROH6 NAPRT KANK3 PRKDC DOT1L

3.86e-1611052413835748872
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

DPF1 TRIML1 IL16 POGZ CUL7 SRCAP MDM2 PLEKHN1 TRIM66 RPTOR MCM3AP CIZ1 XRN1 ASCC3 KPNA3 SUPT20H TTC28 KDM5A KIAA1549 RNF213 NCKAP5L SLC4A1 TUBGCP6 LIMK2 PBRM1 BAZ2A NT5DC2 TCF25 SMARCB1 SIGLEC1 SLFN11

5.92e-1111162413131753913
Pubmed

Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to human chromosome bands 10p15-->p14 and mouse chromosome 13 region A2 by in situ hybridization: identification of a new syntenic relationship.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-094241410393440
Pubmed

Mouse Akr1cl gene product is a prostaglandin D2 11-ketoreductase with strict substrate specificity.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-094241431479646
Pubmed

Identification of an interleukin-3-regulated aldoketo reductase gene in myeloid cells which may function in autocrine regulation of myelopoiesis.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-094241410702227
Pubmed

Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-094241417442338
Pubmed

Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-094241428329705
Pubmed

Crystallization and preliminary X-ray diffraction analysis of mouse 3(17)alpha-hydroxysteroid dehydrogenase.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-094241416511129
Pubmed

Characterization and functional analysis of the 5'-flanking region of the mouse 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-094241415222881
Pubmed

Cloning and characterization of two novel aldo-keto reductases (AKR1C12 and AKR1C13) from mouse stomach.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-094241410526179
Pubmed

Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-094241421521174
Pubmed

Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-09424148274401
Pubmed

Identification of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of rat Leydig cells as type II retinol dehydrogenase.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-094241410803568
Pubmed

AKR1C1 alleviates LPS‑induced ALI in mice by activating the JAK2/STAT3 signaling pathway.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-094241434590152
Pubmed

Structure and activity of the murine type 5 17beta-hydroxysteroid dehydrogenase gene(1).

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-094241410500239
Pubmed

AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-094241419487289
Pubmed

Cloning and chromosomal localization of mouse 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-094241414967952
Pubmed

Localization of 20alpha-hydroxysteroid dehydrogenase mRNA in mouse brain by in situ hybridization.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-094241415193432
Pubmed

Isolation and characterization of a cDNA encoding mouse 3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating enzyme selectively expressed in female tissues.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-094241416191478
Pubmed

Characterization of two isoforms of mouse 3(17)alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase family.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-094241415577209
Pubmed

Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-094241417034817
Pubmed

RECON-Dependent Inflammation in Hepatocytes Enhances Listeria monocytogenes Cell-to-Cell Spread.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-094241429764944
Pubmed

Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-094241417888864
Pubmed

Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-094241419237748
Pubmed

Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-094241428259989
Pubmed

Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-09424147789999
Pubmed

Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-094241420124700
Pubmed

Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-094241416508162
Pubmed

Several distinct enzymes catalyze 20alpha-hydroxysteroid dehydrogenase activity in mouse liver and kidney.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-094241417629694
Pubmed

Characterization of 17alpha-hydroxysteroid dehydrogenase activity (17alpha-HSD) and its involvement in the biosynthesis of epitestosterone.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-094241416018803
Pubmed

Reproductive phenotypes in mice with targeted disruption of the 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-094241417272929
Pubmed

Involvement of 20alpha-hydroxysteroid dehydrogenase in the maintenance of pregnancy in mice.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.25e-094241418667791
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

NCKAP1 PPRC1 POGZ USP19 GGA3 ZCCHC14 MCM3AP CACNA1H BAIAP3 NRCAM TTC28 HEATR5A BAZ2A SPHKAP TCF25 CCAR2 R3HDM1

4.70e-094072411712693553
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

PPRC1 VPS45 PSMD2 POGZ TRIM66 AP2A1 NGEF FBXO7 ASTN2 SMURF2 RECK KPNB1 KPNA3 ATRN SUPT20H NRCAM TTC28 KDM5A HECTD4 NBEA SMG5 IDS EEF1A1 FBXL16 CIAO3 AKR1C3 PRKDC CKAP2 R3HDM1 ABHD12

7.07e-0912852413035914814
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

NCKAP1 INTS1 PSMD2 POGZ CUL7 BIRC6 MCM3AP XRN1 ALDH18A1 NLE1 ASCC3 GCN1 KPNB1 NUP98 IPO4 TGM3 PPP2R1A PBRM1 BAZ2A CCAR2 PRKDC

7.26e-096532412122586326
Pubmed

Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.12e-08524147737980
Pubmed

Pregnane X receptor (PXR) deficiency promotes hepatocarcinogenesis via induction of Akr1c18 expression and prostaglandin F2α (PGF2α) levels.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.12e-085241438788959
Pubmed

Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.12e-085241418003893
Pubmed

Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.12e-085241421851338
Pubmed

Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.12e-085241416984997
Pubmed

Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.12e-085241417872381
Pubmed

Mouse 3alpha-hydroxysteroid dehydrogenase mRNA: a marker of lung maturity.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.12e-085241417064890
Pubmed

Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.12e-085241410672042
Pubmed

The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism.

AKR1C4 AKR1C1 AKR1C2 MALRD1 AKR1C3

1.89e-0813241511682476
Pubmed

Expression analysis of the aldo-keto reductases involved in the novel biosynthetic pathway of tetrahydrobiopterin in human and mouse tissues.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.34e-086241419273550
Pubmed

Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.34e-086241415471942
Pubmed

MEF2 and NR2F2 cooperate to regulate Akr1c14 gene expression in mouse MA-10 Leydig cells.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.34e-086241426748576
Pubmed

Adrenal 20alpha-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.34e-086241417122075
Pubmed

The Gαq/11-provoked induction of Akr1c18 in murine luteal cells is mediated by phospholipase C.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.34e-086241429107092
Pubmed

Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.34e-086241415860270
Pubmed

Decidual prolactin silences the expression of genes detrimental to pregnancy.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.34e-086241417255200
Pubmed

Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.

PSMD2 GSDME AP2A1 AP1G2 GCN1 KPNB1 RNF213 IPO4 EEF1A1 PPP2R1A PRKDC

7.03e-081832411123956138
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

NCKAP1 LRRC24 MAP3K5 AP2A1 RPTOR NGEF KCNAB1 UNC79 KPNB1 CACNB4 NRCAM SEPTIN5 KDM5A HECTD4 ARHGEF18 NBEA IPO4 EEF1A1 PPP2R1A PBRM1 N4BP2 SPHKAP NCAN CCAR2

7.66e-089632412428671696
Pubmed

A phosphodiesterase 11 (Pde11a) knockout mouse expressed functional but reduced Pde11a: Phenotype and impact on adrenocortical function.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.74e-087241433127481
Pubmed

A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.74e-087241412562828
Pubmed

MicroRNA-200a serves a key role in the decline of progesterone receptor function leading to term and preterm labor.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.74e-087241422529366
Pubmed

The Steroidogenic Enzyme AKR1C3 Regulates Stability of the Ubiquitin Ligase Siah2 in Prostate Cancer Cells.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.74e-087241426160177
Pubmed

Aldo-ketoreductase 1c19 ablation does not affect insulin secretion in murine islets.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.74e-087241434843575
Pubmed

17Beta-HSD type 5 expression and the emergence of differentiated epithelial Type II cells in fetal lung: a novel role for androgen during the surge of surfactant.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.74e-087241416337335
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

FAM120B DIS3L2 NCKAP1 PSMD2 POGZ SRCAP BIRC6 AP2A1 RPTOR MCM3AP XRN1 ALDH18A1 AP1G2 NLE1 ASCC3 CORO7 GCN1 PARP12 KPNB1 KPNA3 COMT CHD1L IPO4 TGM3 PPP2R1A BAZ2A TK1 CCAR2 PRKDC

8.06e-0813532412929467282
Pubmed

Nuclear translocation of hypoxia-inducible factors (HIFs): involvement of the classical importin alpha/beta pathway.

KPNB1 KPNA3 KPNA5 EPAS1

1.54e-078241418187047
Pubmed

Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-078241420837989
Pubmed

Androgen Receptor Is Dispensable for X-Zone Regression in the Female Adrenal but Regulates Post-Partum Corticosterone Levels and Protects Cortex Integrity.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-078241433584538
Pubmed

Cloning of mouse 17beta-hydroxysteroid dehydrogenase type 2, and analysing expression of the mRNAs for types 1, 2, 3, 4 and 5 in mouse embryos and adult tissues.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.54e-07824149224647
Pubmed

Decrease in the T-box1 gene expression in embryonic brain and adult hippocampus of down syndrome mouse models.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.76e-079241433348080
Pubmed

Aldo-keto reductase 1C subfamily genes in skin are UV-inducible: possible role in keratinocytes survival.

AKR1C1 AKR1C2 AKR1C3

3.29e-073241319320734
Pubmed

Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis.

AKR1C1 AKR1C2 AKR1C3

3.29e-073241321232532
Pubmed

The p38-interacting protein (p38IP) regulates G2/M progression by promoting α-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5.

SUPT20HL1 SUPT20HL2 SUPT20H

3.29e-073241324220028
Pubmed

Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis.

AKR1C1 AKR1C2 AKR1C3

3.29e-073241331780644
Pubmed

Altered expression of 3 alpha-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes.

AKR1C1 AKR1C2 AKR1C3

3.29e-073241313678667
Pubmed

Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans.

AKR1C4 AKR1C1 AKR1C3

3.29e-07324137626489
Pubmed

Lack of placental neurosteroid alters cortical development and female somatosensory function.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.57e-0710241436313771
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

INTS1 AKR1C2 XRN1 GCN1 KPNA5 SEPTIN5 HSPA4L NBEA IPO4 EEF1A1 PPP2R1A PBRM1 NAPRT NT5DC2 SMARCB1 ABHD12

4.80e-074982411636634849
Pubmed

The HIV-1 passage from cytoplasm to nucleus: the process involving a complex exchange between the components of HIV-1 and cellular machinery to access nucleus and successful integration.

KPNB1 KPNA3 KPNA5 NUP98

7.14e-0711241422509482
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

NCKAP1 PPRC1 SSPOP LCMT2 ZCCHC14 MCM3AP ATRN ARHGEF18

7.40e-0710524189628581
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

NCKAP1 PSMD2 NDUFA2 USP19 AP2A1 RPTOR ASCC3 CORO7 BRAT1 GCN1 KPNB1 FKBP10 ABCC1 HSPA4L NUP98 IPO4 SPAG5 PPP2R1A SCAP TCF25 PRKDC ABHD12

8.11e-079422412231073040
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

FAM120B IL16 NCKAP1 VPS45 PSMD2 NDUFA2 AP2A1 RPTOR NGEF XRN1 CORO7 KPNB1 KPNA3 CACNB4 NRCAM NRDC SEPTIN5 HSPA4L NCKIPSD KIAA1549 NBEA SLC4A1 EEF1A1 PPP2R1A FBXL16 NCAN PCDH1 ABHD12

8.48e-0714312412837142655
Pubmed

Endogenous biotin as a marker of adrenocortical cells with steroidogenic potential.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.07e-0612241421256921
Pubmed

Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.07e-0612241428893949
Pubmed

A Novel Population of Inner Cortical Cells in the Adrenal Gland That Displays Sexually Dimorphic Expression of Thyroid Hormone Receptor-β1.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.07e-0612241425774556
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

INTS1 YTHDC1 BIRC6 ASCC3 GCN1 UNC79 KPNB1 KPNA3 TTC28 NUP98 PPP2R1A PBRM1 N4BP2 SMARCB1 CCAR2

1.16e-064692411527634302
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

PSMD2 CUL7 BIRC6 CRLF3 ALDH18A1 GCN1 KPNB1 KPNA3 ABCC1 ELOA PPM1D NUP98 KIAA1549 RNF213 NBEA FAM171B NCKAP5L PPP2R1A FBXL16 CCAR2 SLFN11 CKAP2 PHLPP2

1.32e-0610492412327880917
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

PSMD2 AP2A1 PTRH1 XRN1 ASCC3 CORO7 GCN1 KPNB1 KPNA5 FKBP10 NRDC HSPA4L NUP98 IPO4 NCKAP5L FAAP100 PPP2R1A TK1 NT5DC2 CCAR2 PRKDC ABHD12

1.40e-069742412228675297
Pubmed

Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins.

YTHDC1 FAM171B NPEPL1 RSPRY1 SHROOM1 CCAR2

1.44e-0651241611853319
Pubmed

Ontogeny of adrenal-like glucocorticoid synthesis pathway and of 20α-hydroxysteroid dehydrogenase in the mouse lung.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.53e-0613241424580729
Pubmed

A link between lung androgen metabolism and the emergence of mature epithelial type II cells.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.53e-0613241415117747
Pubmed

Genetic determinants modulate susceptibility to pregnancy-associated tumourigenesis in a recombinant line of Min mice.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.53e-0613241417062636
Pubmed

Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.13e-0614241419955443
Pubmed

Placental endocrine function shapes cerebellar development and social behavior.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.13e-0614241434400844
Pubmed

HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis.

PSMD2 CUL7 BIRC6 GCN1 TTC28 HSPA4L NT5DC2

2.56e-0687241733711283
Pubmed

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.

INTS1 PIDD1 PSMD2 CUL7 RECK KPNB1 THOC1 COMT IPO4 MARF1 PRKDC HDAC10

2.97e-063222411226514267
Pubmed

Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma.

AKR1C1 AKR1C2 AKR1C3

3.25e-065241315212687
Pubmed

Expression and regulatory effects of murine Schlafen (Slfn) genes in malignant melanoma and renal cell carcinoma.

SLFN12 SLFN13 SLFN11

3.25e-065241324089532
Pubmed

Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association.

KPNB1 KPNA3 KPNA5

3.25e-065241315929992
Pubmed

Subcellular localization of the Schlafen protein family.

SLFN12 SLFN13 SLFN11

3.25e-065241318355440
Pubmed

Schlafen-8 is essential for lymphatic endothelial cell activation in experimental autoimmune encephalomyelitis.

SLFN12 SLFN13 SLFN11

3.25e-065241329528433
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

NCKAP1 CUL7 BIRC6 AP2A1 CRLF3 ALDH18A1 TTC28 NCKIPSD KIAA1549 NCKAP5L PPP2R1A FBXL16 PRKDC R3HDM1

3.30e-064462411424255178
Pubmed

NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.

ASCC3 KPNB1 NBEA PPP2R1A LIMK2 PBRM1 SLFN11 PRKDC

3.51e-06129241823022380
Pubmed

Targeted Disruption of Lats1 and Lats2 in Mice Impairs Adrenal Cortex Development and Alters Adrenocortical Cell Fate.

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.99e-0617241432243503
Pubmed

An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells.

AKR1C4 AKR1C1 AKR1C2 AKR1C3 PCDH1

5.57e-0637241521362171
InteractionTOP3B interactions

VWA5B2 ALKBH4 LRRC24 PPRC1 INTS1 SRCAP BIRC6 MAP3K5 GGA3 TPCN1 ZCCHC14 AP2A1 PIK3CD RPTOR MCM3AP XRN1 AP1G2 NLE1 CACNA1H BRAT1 GCN1 SMURF2 THOC1 PLXNA3 DPH2 PNPLA2 GTSE1 HECTD4 RELB SMG5 IPO4 HES2 TESK1 FAAP100 MST1R SCAP MROH6 NAPRT KANK3 PRKDC DOT1L

5.66e-08147022741int:TOP3B
InteractionBAG2 interactions

VWA5B2 RPS6KB2 LRRK2 CUL7 TRIM66 RBM27 RPTOR AP5Z1 CIZ1 FBXO7 SIK2 MINDY4 ASCC3 DPH2 TUBGCP6 LIMK2 SHROOM1 CCAR2 CKAP2 DOT1L R3HDM1 MAP2K5 EPAS1

6.30e-0762222723int:BAG2
InteractionAKR1C4 interactions

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.06e-0682274int:AKR1C4
InteractionHIF1A interactions

BHLHE41 LRRK2 MDM2 HNF4A USP19 RPTOR GCN1 SMURF2 KPNA3 KPNA5 CASR PPP2R1A FBXL16 CCAR2 PRKDC MAP2K5 EPAS1

1.14e-0544122717int:HIF1A
InteractionEGLN3 interactions

FAM120B VPS45 NUBP1 PSMD2 MDM2 BIRC6 MAP3K5 ZCCHC14 HROB RBM27 RPTOR PARL XRN1 SIK2 ALDH18A1 GCN1 KPNB1 KPNA3 NRDC GTSE1 SMG5 CHD1L IPO4 TUBGCP6 PPP2R1A NT5DC2 N4BP2 TCF25 PRKDC R3HDM1 ABHD12 EPAS1

2.39e-05129622732int:EGLN3
InteractionLATS2 interactions

CUL7 MDM2 MAP3K5 ALDH18A1 HERC6 GCN1 HSPA4L KIAA1549 NCKAP5L PPP2R1A FBXL16 PRKDC MAP2K5

2.59e-0528922713int:LATS2
InteractionSIRT7 interactions

NCKAP1 INTS1 PSMD2 POGZ CUL7 MDM2 BIRC6 MCM3AP XRN1 ALDH18A1 NLE1 ASCC3 GCN1 KPNB1 NUP98 IPO4 TGM3 PPP2R1A PBRM1 BAZ2A CCAR2 PRKDC

3.78e-0574422722int:SIRT7
Cytoband10p15-p14

AKR1C1 AKR1C2 AKR1C3

2.90e-066243310p15-p14
Cytoband2q32

NCKAP1 INPP1 KLF7

5.11e-051424332q32
Cytoband17q12

NLE1 SLFN12 SLFN13 SLFN11 FNDC8

1.90e-0499243517q12
Cytoband10p12.31

ARMC3 CUBN MALRD1

2.09e-0422243310p12.31
Cytoband12q24.13

TPCN1 CFAP73 HECTD4

3.09e-0425243312q24.13
Cytoband15q15.3

LCMT2 STRC STRCP1

3.09e-0425243315q15.3
Cytoband3q27.1

VWA5B2 PSMD2 PARL

3.90e-042724333q27.1
CytobandEnsembl 112 genes in cytogenetic band chr20p13

SIRPB2 ATRN TGM3 CPXM1 SIGLEC1

5.19e-041232435chr20p13
CytobandEnsembl 112 genes in cytogenetic band chr17q12

NLE1 SLFN12 SLFN13 SLFN11 FNDC8

1.23e-031492435chr17q12
CytobandEnsembl 112 genes in cytogenetic band chr10p15

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.37e-03902434chr10p15
CytobandEnsembl 112 genes in cytogenetic band chr3p21

USP19 NCKIPSD DNAH1 MST1R SCAP PBRM1 NT5DC2

1.57e-033162437chr3p21
CytobandEnsembl 112 genes in cytogenetic band chr16p13

NUBP1 CACNA1H CORO7 BAIAP3 ABCC1 FBXL16 CIAO3 MARF1

2.09e-034262438chr16p13
Cytoband20p13

SIRPB2 ATRN CPXM1 SIGLEC1

2.17e-03102243420p13
GeneFamilyAldo-keto reductases

AKR1C4 AKR1C1 AKR1C2 KCNAB1 AKR1C3

1.14e-07151535399
GeneFamilyArmadillo repeat containing|Importins

KPNB1 KPNA3 KPNA5 IPO4

1.38e-05181534596
GeneFamilySchlafen family

SLFN12 SLFN13 SLFN11

2.03e-05715331110
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

ARMC3 KPNB1 KPNA3 KPNA5 SPAG6

3.02e-05431535409
GeneFamilyATP binding cassette subfamily C

ABCC8 ABCC1 ABCC9

1.60e-04131533807
GeneFamilyFibronectin type III domain containing

CHL1 CRLF3 ASTN2 NRCAM FNDC8 ANKFN1

2.42e-031601536555
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

CHL1 LRRC24 NRCAM VSIG10 SIGLEC6 SIGLEC1

2.50e-031611536593
GeneFamilyAdenosine receptors|V-set domain containing

SIRPB2 VSTM4 VSIG10 SIGLEC6 NCAN SIGLEC1

2.66e-031631536590
CoexpressionGSE28737_WT_VS_BCL6_HET_FOLLICULAR_BCELL_UP

CHL1 SRCAP YTHDC1 GCN1 BAIAP3 HSPA4L NPEPL1 SCAP CIAO3 NAPRT MARF1

2.67e-0620024111M9391
CoexpressionMARSON_BOUND_BY_FOXP3_STIMULATED

SUPT20HL1 AFTPH NCKAP1 SUPT20HL2 AKR1C4 MDM2 SNAI3 AKR1C1 AKR1C2 MAP3K5 DLEC1 KPNB1 KPNA3 ELOA SUPT20H NRDC KDM5A HSPA4L SMG5 CHD1L RSPRY1 PPP2R1A PBRM1 LRRC25 AKR1C3 ABHD12

7.02e-06107224126MM1031
CoexpressionGSE8515_IL1_VS_IL6_4H_STIM_MAC_DN

ADGRB1 PIDD1 SRCAP USP19 GGA3 VSTM4 NLE1 CORO7 RNF186 ADAMTS13

1.35e-0519424110M5767
CoexpressionIRITANI_MAD1_TARGETS_UP

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.51e-05172414MM826
CoexpressionGSE17721_PAM3CSK4_VS_GADIQUIMOD_2H_BMDC_UP

LRRK2 GALNT16 GSPT2 THOC1 PLXNA3 TCTE1 CUBN HELQ BAZ2A SMARCB1

1.75e-0520024110M3964
CoexpressionZAMORA_NOS2_TARGETS_DN

AKR1C4 AKR1C1 AKR1C2 UGT2B17 EEF1A1 PPP2R1A AKR1C3

1.85e-05892417MM690
CoexpressionDESCARTES_ORGANOGENESIS_INTERMEDIATE_MESODERM

AKR1C4 AKR1C1 AKR1C2 ADAMTS13 AKR1C3

1.88e-05362415MM3660
CoexpressionWANG_IMMORTALIZED_BY_HOXA9_AND_MEIS1_UP

AKR1C4 AKR1C1 AKR1C2 SLFN12 AKR1C3

2.16e-05372415MM630
CoexpressionMIKKELSEN_MCV6_LCP_WITH_H3K4ME3

AKR1C4 AKR1C1 AKR1C2 DQX1 ADAMTS13 PRX TGM3 AKR1C3 RUFY4

3.55e-051742419MM836
CoexpressionGOLDRATH_IMMUNE_MEMORY

NCKAP1 AKR1C4 AKR1C1 AKR1C2 RECK AKR1C3

4.19e-05692416MM621
CoexpressionJINESH_BLEBBISHIELD_VS_LIVE_CONTROL_UP

INTS1 PIDD1 MDM2 YTHDC1 AKR1C2 HROB PPM1D RNF213 MYRFL TUBGCP6 NUTM2E N4BP2 EPAS1

5.58e-0538024113M38974
CoexpressionVARELA_ZMPSTE24_TARGETS_DN

AKR1C4 AKR1C1 AKR1C2 INMT AKR1C3

5.71e-05452415MM1173
CoexpressionLIN_TUMOR_ESCAPE_FROM_IMMUNE_ATTACK

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.41e-05242414MM766
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_C_DN

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.58e-05252414MM480
CoexpressionGINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN

PPRC1 INTS1 CUL7 SRCAP AP5Z1 SMG5 NCKAP5L NUTM2E LIMK2 CCAR2 HDAC10 DOT1L

7.59e-0533824112M17094
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

CHL1 DPF1 NUTM2A LRRK2 ADGRB1 SSPOP AKR1C1 AKR1C2 PIK3CD NGEF UNC79 PLXNA3 CACNB4 KIAA1549 NBEA FAM171B IDS SLC4A1 FBXL16 KLF7 N4BP2 NCAN R3HDM1 PCDH1

9.32e-05110624124M39071
CoexpressionGSE10240_IL17_VS_IL17_AND_IL22_STIM_PRIMARY_BRONCHIAL_EPITHELIAL_CELLS_UP

CHL1 PIDD1 SNAI3 HROB XRN1 SMURF2 TESK1 CIAO3 NAPRT

1.00e-041992419M313
CoexpressionGSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_MONOCYTE_DN

IL16 AKR1C2 FES GCN1 COMT HSPA4L NCKIPSD KANK3 CCAR2

1.00e-041992419M4997
CoexpressionGSE17721_PAM3CSK4_VS_CPG_2H_BMDC_UP

AFTPH SRCAP TPCN1 GSPT2 GRIN3B PLXNA3 TCTE1 KDM5A SMG5

1.00e-041992419M3857
CoexpressionGSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_CORTICOSTERONE_TREATED_UP

FAM120B INPP1 SRCAP GSDME COMT PPM1D NCKIPSD CHD1L R3HDM1

1.00e-041992419M7736
CoexpressionGSE14308_TH17_VS_INDUCED_TREG_UP

ALKBH4 INPP1 SNAI3 GSPT2 DQX1 ATRAID SUPT20H KDM5A PRKDC

1.04e-042002419M3385
CoexpressionGSE26669_CTRL_VS_COSTIM_BLOCK_MLR_CD8_TCELL_DN

FAM120B LRRK2 SRCAP LCMT2 USP19 CRLF3 IDS KLF7 PHLPP2

1.04e-042002419M4667
CoexpressionGSE17721_CTRL_VS_POLYIC_4H_BMDC_DN

YTHDC1 PLEKHN1 ABCC8 CRLF3 XRN1 PARP12 FMOD PEX26 SHROOM1

1.04e-042002419M3714
CoexpressionSERVITJA_ISLET_HNF1A_TARGETS_DN

AKR1C4 HNF4A AKR1C1 AKR1C2 UGT2B17 RNF186 AKR1C3

1.32e-041212417MM935
CoexpressionBYSTRYKH_HEMATOPOIESIS_STEM_CELL_SCP2_QTL_TRANS

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.58e-04302414MM853
ToppCellPCW_10-12-Epithelial-Epithelial_ciliated|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ARMC3 UGT2B17 DLEC1 GRIN3B BAIAP3 CFAP47 CFAP73 TGM3 ANKFN1

4.74e-071742419b8d1c556290d188f56aeefc17f03119686945fe7
ToppCellPCW_10-12-Epithelial-Epithelial_ciliated-epi_ciliated_(14)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ARMC3 UGT2B17 DLEC1 GRIN3B BAIAP3 CFAP47 CFAP73 TGM3 ANKFN1

4.74e-07174241900cf27bc23af1472a507be31fba6245a8fdd901b
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWA5B2 AKR1C4 ABCC8 BAIAP3 CFAP47 TSPEAR CASR SPAG5 KCNV1

5.22e-071762419d54543510c804474c5c32e007cd699e75fc5aaba
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 LRRK2 PLEKHN1 ASTN2 THEMIS2 RNF213 CASR RELB MST1R

9.47e-071892419aadb7a2de4cbe7f0958651f2739bba430b93f5c1
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 LRRK2 PLEKHN1 ASTN2 THEMIS2 RNF213 CASR RELB MST1R

9.47e-0718924198977f3295b7df7c7474b3f371de90a82ae4bb50c
ToppCellLPS_only-Epithelial_airway-Ciliated_cells-Ciliated|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARMC3 DLEC1 TCTE1 CFAP73 SPAG6 DNAH1 TGM3 ANKFN1

2.01e-0615424189ca71d440c4f87781e6525b8141e7d8d470b6a8e
ToppCellLPS_only-Epithelial_airway-Ciliated_cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARMC3 DLEC1 TCTE1 CFAP73 SPAG6 DNAH1 TGM3 ANKFN1

2.01e-06154241858072ce422d09f2de602580325eaac6c4ec6c136
ToppCell356C-Myeloid-Dendritic-cDC_proliferating_2|356C / Donor, Lineage, Cell class and subclass (all cells)

GSDME DPY19L2 GTSE1 SPAG5 CSF1R LRRC25 TK1 RUFY4

5.41e-0617624184bba41ebf9dd187c8705a6997ed039878de62b4e
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ARMC3 NGEF DLEC1 GRIN3B CFAP73 SPAG6 DNAH1 ANKFN1

6.38e-06180241892fb01b91261b3103454924cde56add337b41844
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ARMC3 PTRH1 DLEC1 GRIN3B CFAP47 CFAP73 SPAG6 ANKFN1

6.65e-061812418dfce05bd472f67e6e2bb60ebd6fd34f0a9aeeca6
ToppCellHippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Lhx1_(Cajal-retzius)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

TGFBR3L PIDD1 PLEKHN1 UPK3A GTSE1 TSPEAR

6.82e-06852416f9e874ae2b3eadf58fbbe7367c5f498a357166ca
ToppCellASK452-Epithelial-Type_2|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

ALDH18A1 HEATR4 PRX TGM3 CLIP3 LRRC25

6.82e-06852416523a532e91aa271faab67d0256919b67af2bd7d8
ToppCellHippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Lhx1_(Cajal-retzius)|Hippocampus / BrainAtlas - Mouse McCarroll V32

TGFBR3L PIDD1 PLEKHN1 UPK3A GTSE1 TSPEAR

6.82e-068524162c94ff338633c39edb4a3a69a04be33db764c586
ToppCellControl-Epithelial_cells-Airway_ciliated|Control / group, cell type (main and fine annotations)

ARMC3 PTRH1 DLEC1 CFAP47 CFAP73 SPAG6 CCDC148 ANKFN1

6.92e-061822418fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCellAdult-Epithelial-ciliated_cell-D122|Adult / Lineage, Cell type, age group and donor

ARMC3 DLEC1 GRIN3B BAIAP3 CFAP47 CFAP73 SPAG6 ANKFN1

6.92e-0618224187ded554a4b441e6496db673ba206c0d76ccad7d9
ToppCellAdult-Epithelial-ciliated_cell-D175|Adult / Lineage, Cell type, age group and donor

ARMC3 DLEC1 BAIAP3 CFAP47 CFAP73 SPAG6 SLFN13 ANKFN1

7.80e-06185241830f4980dee6cd5959655f8d74049f3bfb5312611
ToppCellAdult-Epithelial-ciliated_cell-D231|Adult / Lineage, Cell type, age group and donor

ARMC3 DLEC1 CFAP47 DPY19L2 CFAP73 SPAG6 CCDC148 ANKFN1

8.77e-06188241834b11f72ca73153d02edcd09b38983ad1a504659
ToppCellnucseq-Epithelial-Epithelial_Airway|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ARMC3 PTRH1 DLEC1 CFAP47 CFAP73 SPAG6 CCDC148 ANKFN1

9.85e-0619124181c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ARMC3 PTRH1 DLEC1 CFAP47 CFAP73 SPAG6 CCDC148 ANKFN1

9.85e-061912418e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ARMC3 PTRH1 DLEC1 CFAP47 CFAP73 SPAG6 CCDC148 ANKFN1

9.85e-0619124189d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCell5'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_A-Branch_A2_(IPAN/IN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CHL1 DPF1 LRRC24 AKR1C1 AKR1C2 ABCC8 NRCAM NBEA

1.28e-0519824187b9c7ce5d6b7df8db85943b65da1a2c202a8bb53
ToppCellTracheal-10x3prime_v2-Immune_Myeloid-Macrophage_alveolar-Macro_alv_MT|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

LRRK2 SLC25A30 PIK3CD THEMIS2 HEATR5A CARD8 SIGLEC1 DOT1L

1.33e-0519924184e0b73d88b1345ec63a9e5629762341e75beb47f
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_ciliated-Ciliated|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ARMC3 PTRH1 DLEC1 GRIN3B CFAP47 CFAP73 SPAG6 ANKFN1

1.37e-052002418af6a551f83808c1c839df7ba7b1702ca28ea6e1b
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal-Cortical_neuron|GW16 / Sample Type, Dataset, Time_group, and Cell type.

CHL1 AKR1C1 AKR1C2 TTC28 EEF1A1 PPP2R1A CLIP3 KLF7

1.37e-05200241819055194a5e0ea122f1b8fc62df44813f6843c95
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ARMC3 DLEC1 GRIN3B CFAP47 CFAP73 SPAG6 DNAH1 ANKFN1

1.37e-05200241831d75c26055177d656df1fbb10b764cebd61e122
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ARMC3 DLEC1 GRIN3B CFAP47 CFAP73 SPAG6 DNAH1 ANKFN1

1.37e-052002418e1dce91c6c531bb212002a14705e496d77ad3490
ToppCellfacs-Lung-18m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2-17-52|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ASB6 PIK3CD SMG5 FAM171B CSF1R LRRC25 HAL

1.49e-05146241726493014daa432db721613ef480d133f3da9eb58
ToppCellLPS-IL1RA-Epithelial_airway-Ciliated_cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARMC3 DLEC1 TCTE1 CFAP73 SPAG6 DNAH1 ANKFN1

1.86e-05151241781cf939ed4df9574fbfff265e109cb9f947d7e6e
ToppCellLPS-IL1RA-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARMC3 DLEC1 TCTE1 CFAP73 SPAG6 DNAH1 ANKFN1

1.86e-0515124179cbcbbc22965a9f0be8364e733d205dd64f2a533
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

VWA5B2 HNF4A ABCC8 UGT2B17 GRIN3B BAIAP3 CFAP73

1.94e-051522417854c841c1fc6300b7e9be9c98cbf9b0ce2678690
ToppCellP07-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

VWA5B2 DPF1 MAP3K5 NRCAM HEATR5A DNAH1 NAPRT

2.02e-0515324175501095bcf73080872ae01128f21399f9cfc5dd1
ToppCellControl-Epithelial_airway-Ciliated_cells-Ciliated|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARMC3 DLEC1 CFAP73 SPAG6 DNAH1 CCDC148 ANKFN1

2.11e-0515424174e3bc24043144143842627cacf6f90dda2228910
ToppCellControl-Epithelial_airway-Ciliated_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARMC3 DLEC1 CFAP73 SPAG6 DNAH1 CCDC148 ANKFN1

2.11e-0515424177556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARMC3 DLEC1 CFAP73 SPAG6 DNAH1 CCDC148 ANKFN1

2.20e-0515524175f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARMC3 DLEC1 CFAP73 SPAG6 DNAH1 CCDC148 ANKFN1

2.20e-0515524170944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PPRC1 SNAI3 TESK1 MROH6 NT5DC2 SIGLEC1 ABHD12

2.29e-051562417e0aef6104be16b12304b8e30358f444c1660e92f
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PPRC1 SNAI3 TESK1 MROH6 NT5DC2 SIGLEC1 ABHD12

2.29e-0515624175b2781d38a83b4b0f8a53cf321ce5db3a07d0818
ToppCellLeuk-UTI-Lymphocyte-B-Plasmablast|Leuk-UTI / Disease, Lineage and Cell Type

LRRC24 ASTN2 GCN1 GTSE1 MEI1 CPXM1 LBX2

2.49e-05158241705a29c2d5506a25ccdfa4c6a86e9188977a18272
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BHLHE41 SIRPB2 ADA2 XRN1 KCNAB1 HEATR4 BAZ2A

3.55e-051672417881f64db8dea3faa7588bf04d87c20924a4e5952
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

VWA5B2 ARMC3 TCTE1 CUBN DNAH1 CCDC148 SLFN13

3.83e-0516924178bca402e144819cb9a8d431d6bf9429be2fff6d6
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ARMC3 DLEC1 BAIAP3 NBEA SPAG6 CCDC148 ANKFN1

3.83e-05169241714aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCellE16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal-Deuterosomal_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

UPK3A CFAP47 TCTE1 HSPA4L CFAP73 SPAG6 NCAN

4.12e-0517124174f2a83d8091f1fd29542d2e5add57fd482e921b5
ToppCellwk_20-22-Epithelial-Proximal_epithelial-Deuterosomal|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

ARMC3 DLEC1 BAIAP3 CFAP47 HSPA4L HES2 SPAG6

4.12e-05171241752aec5f6677fe2f7a36fb5b18117a4cffaeff58f
ToppCellwk_08-11-Epithelial-Proximal_epithelial-Deuterosomal|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

ARMC3 DLEC1 CFAP47 TCTE1 CFAP73 HES2 SPAG6

4.28e-05172241708ad76412c9cc3504141797b44b88478ced87476
ToppCelldroplet-Thymus-nan-21m-Lymphocytic-B_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFBR3L CUL7 CORO7 ATRN MEI1 CLIP3 NCAN

4.44e-0517324170a0cd40bb5f61431fe34758626c8a63ec610a8a5
ToppCellfacs-Lung-Endomucin_-18m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIK3CD THOC1 IDS TGM3 CSF1R BAZ2A N4BP2

4.44e-051732417c31076c725f4cd912c56903592a2d9356ae59f54
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_1|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

USP19 MCM3AP ALDH18A1 ATRN FAAP100 FBXL16 EPAS1

4.44e-051732417efb8072475000888efe088d00e870c56ffad4172
ToppCellfacs-Lung-Endomucin_-18m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIK3CD THOC1 IDS TGM3 CSF1R BAZ2A N4BP2

4.44e-051732417a4ed191cfdf6588b7f3672995bf0a4fe9e4b8df6
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

USP19 MCM3AP ALDH18A1 ATRN FAAP100 FBXL16 EPAS1

4.61e-05174241758300d64d3b6fd9ba1b6c87ea83b2777eb6be2f4
ToppCellPND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CHL1 LRRC24 ABCC8 FAM171B SLC4A1 CCDC148 KCNV1

4.78e-0517524178362a46f5804333baa84cd56d450bc147f372a7e
ToppCellPND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CHL1 LRRC24 ABCC8 FAM171B SLC4A1 CCDC148 KCNV1

4.78e-0517524178b4c62e608f0ec84e563bbf0ebffe3ed44085298
ToppCellGlobus_pallidus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Cck_(Substantia_Innominata_(SI))|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

TGFBR3L UPK3A MYRFL MALRD1 HAL

5.04e-057424157c77b7d84fd8d9d823bbfc586f2b95865e75ab0b
ToppCellGlobus_pallidus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

TGFBR3L UPK3A MYRFL MALRD1 HAL

5.04e-05742415b4b961beb98ccf7551bb51773555615586da597d
ToppCellGlobus_pallidus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

TGFBR3L UPK3A MYRFL MALRD1 HAL

5.04e-05742415ce00c59e0663093e33317227d31058a08db2d071
ToppCellGlobus_pallidus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Cck_(Substantia_Innominata_(SI))-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

TGFBR3L UPK3A MYRFL MALRD1 HAL

5.04e-05742415e008982158a3fbade8af9434eb32f20e00f92ba8
ToppCellCiliated_cells-A-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

DLEC1 BAIAP3 SEPTIN5 CFAP73 SPAG6 CCDC148 TGM3

5.32e-051782417255473ee6df8a13079fb3bb61038162a40cb4c2c
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ARMC3 DLEC1 GRIN3B CFAP73 SPAG6 DNAH1 SLFN13

5.32e-0517824173b12db04006db6e94fc45649a4b3a63b92f21a61
ToppCellCiliated_cells-A-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

ARMC3 DLEC1 GRIN3B BAIAP3 TCTE1 CFAP73 SPAG6

5.51e-0517924170e6c22de2e3fb0ff23b3301863cf4011c5c59dff
ToppCellwk_08-11-Epithelial-Proximal_epithelial-Ciliated|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

ARMC3 UGT2B17 GRIN3B CFAP47 CFAP73 SPAG6 TGM3

5.91e-0518124178eed9d46d924b16f6dd1a025ff612244b02b4391
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ADA2 FES UPK3A COMT CSF1R NAPRT SIGLEC1

6.12e-051822417c3fb1460160744144aa31afc76c0a4d42ebdeb91
ToppCellCiliated_cells-B-SSc-ILD_02|World / lung cells shred on cell class, cell subclass, sample id

ARMC3 DLEC1 BAIAP3 TCTE1 CFAP73 SPAG6 SLFN13

6.12e-051822417e44c4810dc7d51a76b86d7623f8e4c4d8b4bf2fc
ToppCellPericytes-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

NGEF KCNAB1 CACNA1H NRCAM MYRFL CLIP3 CPXM1

6.33e-0518324174617b18da8d699a44e4c47980197b1e7eb951470
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ARMC3 DLEC1 CFAP47 DPY19L2 CFAP73 SPAG6 ANKFN1

6.55e-0518424175daff849625f2f41d56615569c0ed59cd733b34c
ToppCellfacs-Large_Intestine-Proximal-24m-Epithelial-enteroendocrine_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWA5B2 BHLHE41 ABCC8 CACNA1H BAIAP3 FBXL16 LBX2

6.78e-0518524172a8104f610fa5ce618f8105521616722462a0d42
ToppCellCOVID-19-Epithelial_cells-Airway_ciliated|COVID-19 / group, cell type (main and fine annotations)

ARMC3 DLEC1 CFAP47 CFAP73 SPAG6 CCDC148 ANKFN1

6.78e-05185241718a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCell15-Airway-Epithelial-Multiciliated_cell|Airway / Age, Tissue, Lineage and Cell class

ARMC3 UGT2B17 DLEC1 GRIN3B CFAP73 SPAG6 ANKFN1

6.78e-0518524170998b6bf44287eebbf39249fff23fc3689e44c4e
ToppCelldroplet-Liver-LIVER_HEP-30m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCKAP1 LRRK2 CUL7 DLC1 VSIG10 TUBGCP6 CCAR2

6.78e-051852417bdd2e6cb20294b39a9d856004bf57ba69cf877e2
ToppCellNS-moderate-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ARMC3 DLEC1 BAIAP3 CFAP47 CFAP73 SPAG6 ANKFN1

7.01e-05186241785787ff207f109ec7e3c0f729ba9bda739c2fdc9
ToppCellCiliated_cells-B-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

ARMC3 DLEC1 GRIN3B BAIAP3 TCTE1 CFAP73 SPAG6

7.25e-0518724172b4262c2e7c7830a976be168cee6eeb738d4feda
ToppCellcontrol-immature_Neutrophil|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SIRPB2 GGA3 ZCCHC14 THEMIS2 PEX26 SHROOM1 ARSD

7.75e-051892417bdfd120900ba58d5e54765f7b576e1f8cc2401bf
ToppCellcellseq2-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ALKBH4 SRCAP SIK2 BRAT1 ATRN NCKAP5L R3HDM1

7.75e-051892417bccb3481ffed597c845fe860da658505316105b5
ToppCellCOVID-19-lung-Ciliated|lung / Disease (COVID-19 only), tissue and cell type

ARMC3 DLEC1 CFAP47 CFAP73 SPAG6 CCDC148 ANKFN1

7.75e-05189241727329c4661aebabd19fac7fe5dca263fe99d76f3
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWA5B2 GALNT16 TRIM66 ABCC9 FAM171B CLIP3 CPXM1

7.75e-051892417f0a2d4ef9896d764971ebbc6952510c128bb76e8
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWA5B2 GALNT16 TRIM66 ABCC9 FAM171B CLIP3 CPXM1

7.75e-051892417378f26f751ab4b470948c35dd8347de72dd12ff7
ToppCellSupraBC-Differ-KC|World / shred by cell class for mouse tongue

PLEKHN1 SEPTIN5 KDM5A TGM3 TREX2 RNF39 PCDH1

7.75e-0518924176412741b88e241304033b41effca0c77a374d907
ToppCellAdult-Epithelial-ciliated_cell|Adult / Lineage, Cell type, age group and donor

ARMC3 DLEC1 CFAP47 CFAP73 SPAG6 CCDC148 ANKFN1

7.75e-051892417b679920f0993e917dd86da082113bfbd85ea1ca5
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 LRRK2 DNAH14 ASTN2 CASR MYRFL CCDC148

8.01e-0519024173fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCellfacs-Tongue-nan-3m-Epithelial-suprabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHL1 PLEKHN1 DLC1 TGM3 TREX2 RNF39 PCDH1

8.01e-051902417719a5cecc3e8001ca9c38165258b5ff9c800713a
ToppCellCiliated_cells-B|World / lung cells shred on cell class, cell subclass, sample id

ARMC3 DLEC1 GRIN3B BAIAP3 CFAP73 SPAG6 SLFN13

8.01e-0519024177031fbedc13be1a00f6333ad6d51849c3739c2e6
ToppCellIPF-Epithelial-Ciliated|IPF / Disease state, Lineage and Cell class

ARMC3 PTRH1 CFAP47 CFAP73 SPAG6 CCDC148 ANKFN1

8.56e-051922417354adc1354bf596fbc60dd45c0169688e6f45165
ToppCellPBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LRRK2 ADA2 FES NRDC CSF1R NAPRT SIGLEC1

8.84e-0519324174fb020f11fd7aff06952bfeaabc79b2c7b8873f6
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

BIRC6 ATRN HEATR5A PBRM1 BAZ2A N4BP2 PRKDC

8.84e-051932417abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellmedial-2-Hematologic-Nonclassical_Monocyte|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LRRK2 SIRPB2 PNMA5 UPK3A CSF1R LRRC25 HAL

9.13e-051942417202e5070728191c46161fa7d931f00be1c7559d4
ToppCellPBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

LRRK2 ADA2 FES NRDC CSF1R NAPRT SIGLEC1

9.13e-051942417885355ebe98e974f841cc59dce3b5228c642c5d0
ToppCellcontrol-Myeloid-Neutrophils_2|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

XRN1 HERC6 PARP12 KPNB1 RNF213 LIMK2 SIGLEC1

9.13e-051942417267e213e8efe53aadfe553a2ca010a0e3b4b8939
ToppCellmedial-Hematologic-Nonclassical_Monocyte-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LRRK2 SIRPB2 PNMA5 UPK3A CSF1R LRRC25 HAL

9.13e-051942417002cd317732fc6b0d9a72fb46199f71db5a638a7
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ABCC8 TTC28 KIAA1549 PRX KANK3 PCDH1 EPAS1

9.13e-05194241740842a7160f337bfc191ee15fbda3e3d38a04c57
ToppCell3'_v3-blood-Lymphocytic_NK-Cycling_NK|blood / Manually curated celltypes from each tissue

HROB DSCC1 GTSE1 SPAG5 SLFN13 TK1 AKR1C3

9.13e-051942417bf9734abaad603ade2a6a6940918aaf1e1c4e2cd
ToppCellmedial-Hematologic-Nonclassical_Monocyte|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LRRK2 SIRPB2 PNMA5 UPK3A CSF1R LRRC25 HAL

9.13e-051942417ac203d388a3a3884e316dec0dcbd408e43c6ef6c
ToppCell21-Trachea-Immune-Hematopoietic,_Macrophage|Trachea / Age, Tissue, Lineage and Cell class

FES KCNAB1 UPK3A THEMIS2 CSF1R LRRC25 SIGLEC1

9.13e-0519424173c4ac5f91b10802990b84db3406f5e71f8ee8b74
ToppCell(3)_Chondrocytes-(30)_Chondro|(3)_Chondrocytes / Cell class and subclass of bone marrow stroma cells in homeostatis

BHLHE41 CRLF3 RECK NRCAM ABCC9 EEF1A1 SPHKAP

9.42e-051952417f5597d3ed37770c6fa2b339f98a80ac7ecd4f9ff
ToppCell10x5'|World / Manually curated celltypes from each tissue

FAM120B IL16 AP1G2 ABCC1 RELB EEF1A1 PPP2R1A

9.42e-051952417de28b998793271c4f69ce9e183c3e62d809e9cc8
ToppCellAdult-Immune-monocyte-D122|Adult / Lineage, Cell type, age group and donor

SIRPB2 ADA2 PIK3CD FES UPK3A THEMIS2 CSF1R

9.73e-05196241716b0acb6157534938ca83d4e909471e33a7d3c52
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Nonclassical_Monocyte|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ADA2 FES BRAT1 COMT CSF1R LRRC25 SIGLEC1

9.73e-05196241784c7f2153b5a9c4da7ae48fdf816a163c33d9a5e
ToppCellNS-moderate-d_07-13-Epithelial-Secretory|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CHL1 NCKAP1 AKR1C1 AKR1C2 HERC6 AKR1C3 EPAS1

9.73e-05196241747930de6b47b7bf22d8dae8b7419a9cd1d22f0ea
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Layer_VI_Pan-area|World / Primary Cells by Cluster

CHL1 DPF1 DLC1 NGEF NRCAM NBEA SPHKAP

1.00e-04197241779b9e7f2e8e33b3c547f716be5667156c48b0dfc
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CHL1 NCKAP1 AKR1C2 ATRN SPAG6 PCDH1 EPAS1

1.00e-0419724175c4cee914baf7cb43e9cb99cc9e3ae823856dc15
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alv_dividing|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

BHLHE41 SIRPB2 THEMIS2 GTSE1 SIGLEC1 SLFN11 CKAP2

1.00e-041972417d669d90c3f9e98b41bcbc49dbdc5698e0b42597c
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ARMC3 NGEF DLEC1 CFAP47 DPY19L2 CFAP73 DNAH1

1.00e-0419724176e4a411ef823ce9e16f420e185e21fa19d13af34
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_aerocyte_capillary-EC_aerocyte_capillary_L.2.0.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

INPP1 PRX KLF7 INMT KANK3 PCDH1 EPAS1

1.00e-04197241786591849476b3925857a82b6913f65e74df200c1
Drugcloxazolam

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.09e-0842344ctd:C005522
DrugPregnanes

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.09e-0842344ctd:D011278
Drugtetralol

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.09e-0842344ctd:C019106
Drug3',3'',5',5''-tetrabromophenolphthalein

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.09e-0842344ctd:C018156
DrugHydroxysteroids

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.39e-0852344ctd:D006914
Drugcresolphthalein

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.39e-0852344ctd:C010092
DrugMedazepam

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.61e-0762344ctd:D008472
DrugNitrazepam

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.37e-0782344ctd:D009567
Drugcyclopentanol

AKR1C1 AKR1C2 AKR1C3

1.07e-0632343ctd:C016327
Drugcyclopentanone

AKR1C1 AKR1C2 AKR1C3

1.07e-0632343ctd:C007201
Drug5-dihydrodeoxycorticosterone

AKR1C4 AKR1C1 AKR1C2

1.07e-0632343ctd:C454687
Drug4-benzoylbenzoic acid

AKR1C1 AKR1C2 AKR1C3

1.07e-0632343ctd:C058818
Drugdichloro(4-cymene)ruthenium(II)

AKR1C1 AKR1C2 AKR1C3

1.07e-0632343ctd:C530610
Drug4-hydroxybenzoic acid

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.32e-0692344ctd:C038193
Drug20-alpha-Dihydroprogesterone

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.32e-0692344ctd:D004092
Drugoctyl gallate

AKR1C4 AKR1C1 AKR1C2 AKR1C3

2.18e-06102344ctd:C016627
DrugDihydroxydihydrobenzopyrenes

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.39e-06112344ctd:D004101
Drugchlordecone alcohol

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.39e-06112344CID000013946
Drugtetrahydrodeoxycorticosterone

AKR1C4 AKR1C1 AKR1C2

4.25e-0642343ctd:C009413
Druggliquidone

AKR1C1 AKR1C2 AKR1C3

4.25e-0642343ctd:C010969
DrugDBD-H

AKR1C4 AKR1C1 AKR1C3

4.25e-0642343CID000131382
DrugPhenolphthalein

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.05e-06122344ctd:D020113
DrugBetahistine mesylate [54856-23-4]; Up 200; 17.2uM; MCF7; HT_HG-U133A

PIDD1 SRCAP MDM2 SIK2 BAIAP3 PNPLA2 FMOD COMT RELB SMG5 PCDH1

5.94e-06195234112833_UP
DrugMoxonidine [75438-57-2]; Down 200; 16.6uM; HL60; HT_HG-U133A

BHLHE41 PIDD1 TPCN1 AP5Z1 RELB IDS FAAP100 PEX26 CSF1R MAP2K5 EPAS1

6.23e-06196234112923_DN
DrugGlycocholic acid [475-31-0]; Up 200; 8.6uM; MCF7; HT_HG-U133A

MDM2 HNF4A ZCCHC14 HROB KCNAB1 CACNA1H BAIAP3 KDM5A RELB CSF1R MAP2K5

6.23e-06196234113315_UP
DrugHydroquinine hydrobromide hydrate [304695-81-6]; Up 200; 9.4uM; MCF7; HT_HG-U133A

INTS1 PIDD1 SRCAP MDM2 ZCCHC14 DLC1 ASTN2 HERC6 TESK1 KLF7 AKR1C3

6.87e-06198234116263_UP
DrugDMBA-3,4-dihydrodiol

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.23e-06132344CID000050096
Drugflunisolide

AKR1C4 AKR1C1 AKR1C2 AKR1C3

7.23e-06132344ctd:C007734
Drug5-alpha-Dihydroprogesterone

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.00e-05142344ctd:D043582
Drug1-acenaphthenol

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.00e-05142344CID000022750
DrugMeclofenamic Acid

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.00e-05142344ctd:D008469
DrugNSC86000

AKR1C1 AKR1C2 AKR1C3

1.06e-0552343CID000257630
DrugWithaferin A [5119-48-2]; Up 200; 1uM; MCF7; HT_HG-U133A

INTS1 HROB PIK3CD CACNA1H UPK3A HSPA4L CASR MST1R AKR1C3 PHLPP2

1.80e-05180234104376_UP
DrugAC1L93E5

AKR1C4 AKR1C1 AKR1C3

2.10e-0562343CID000412383
DrugSImax

RPTOR FMOD CSF1R

2.10e-0562343CID005371578
DrugEstazolam

AKR1C1 AKR1C2 AKR1C3

2.10e-0562343ctd:D004949
Drug3-hydroxyhexobarbital

AKR1C4 AKR1C2 AKR1C3

2.10e-0562343CID000439898
DrugGlipizide

AKR1C1 AKR1C2 AKR1C3

2.10e-0562343ctd:D005913
Drugacenaphthene-1-ol

AKR1C1 AKR1C2 AKR1C3

2.10e-0562343ctd:C023723
Drugphenolphthalein

AKR1C4 AKR1C1 AKR1C2 UGT2B17 COMT AKR1C3

2.86e-05582346CID000004764
DrugGlyburide

AKR1C1 AKR1C2 ABCC8 ABCC1 ABCC9 AKR1C3

2.86e-05582346ctd:D005905
Drugsilver iodide

MAP3K5 FES KPNB1 KPNA3 KPNA5 CTF1

2.86e-05582346CID000024563
Drug5230742; Up 200; 17uM; MCF7; HT_HG-U133A_EA

INPP1 MDM2 DLC1 ASB6 AP5Z1 CACNA1H PLXNA3 FKBP10 PNPLA2 SMG5

2.87e-0519023410970_UP
Drugcloxazolam

AKR1C1 AKR1C2 AKR1C3 CKAP2

2.97e-05182344CID000002816
DrugRuthenium Compounds

MDM2 AKR1C1 AKR1C2 AKR1C3

2.97e-05182344ctd:D017975
Drug5194442; Up 200; 20uM; PC3; HT_HG-U133A

ALKBH4 PIDD1 MDM2 TRIM66 AP5Z1 ASTN2 SMG5 NPEPL1 CARD8 AKR1C3

3.43e-05194234106553_UP
DrugMethyldopa (L,-) [555-30-6]; Up 200; 19uM; HL60; HG-U133A

POGZ SRCAP TRIM66 PARP12 KDM5A ADAMTS13 IDS SLC4A1 BAZ2A MAP2K5

3.58e-05195234101619_UP
Drug4-hydroxyequilenin-o-quinone

AKR1C1 AKR1C2 AKR1C3

3.64e-0572343ctd:C117714
Drugzomepirac

AKR1C1 AKR1C2 AKR1C3

3.64e-0572343ctd:C020549
Drugoxcarbazepine

AKR1C4 AKR1C1 AKR1C2 AKR1C3

3.73e-05192344ctd:C036006
DrugHesperetin [520-33-2]; Up 200; 13.2uM; HL60; HG-U133A

AP5Z1 CIZ1 FES SIK2 AP1G2 NUP98 IDS SLC4A1 TGM3 R3HDM1

3.74e-05196234102031_UP
Drug9,10-phenanthrenequinone

AKR1C4 AKR1C1 COMT AKR1C3 SIGLEC1 HAL

3.83e-05612346CID000006763
DrugTocainide hydrochloride; Down 200; 17.4uM; HL60; HT_HG-U133A

MDM2 HROB GSDME MCM3AP HERC6 KDM5A RELB TESK1 CSF1R KLF7

3.91e-05197234102931_DN
DrugLobeline alpha (-) hydrochoride [134-63-4]; Down 200; 10.6uM; MCF7; HT_HG-U133A

RPS6KB2 SRCAP SIK2 PARP12 PNPLA2 SUPT20H GTSE1 NUP98 IDS MAP2K5

3.91e-05197234102763_DN
DrugChloroquine diphosphate [50-63-5]; Up 200; 7.8uM; MCF7; HT_HG-U133A

BHLHE41 SRCAP ABCC8 KCNAB1 AP1G2 CACNA1H BAIAP3 PARP12 FKBP10 ADAMTS13

3.91e-05197234102869_UP
DrugMolsidomine [25717-80-0]; Down 200; 16.6uM; HL60; HG-U133A

TRIM66 GSDME AP5Z1 CIZ1 AP1G2 ABCC1 SUPT20H NUP98 FAAP100 MAP2K5

3.91e-05197234101711_DN
Drugdeferoxamine mesylate salt; Down 200; 100uM; PC3; HG-U133A

ALKBH4 LCMT2 DLC1 MCM3AP FKBP10 SUPT20H GTSE1 NUP98 CHD1L FAAP100

3.91e-0519723410460_DN
DrugPiperacillin sodium salt [59703-84-3]; Down 200; 7.4uM; MCF7; HT_HG-U133A

PIDD1 SRCAP USP19 ZCCHC14 DLC1 KPNA5 FKBP10 COMT ADAMTS13 BAZ2A

3.91e-05197234103939_DN
DrugRoxarsone [121-19-7]; Up 200; 15.2uM; MCF7; HT_HG-U133A

NDUFA2 SRCAP TPCN1 PIK3CD CIZ1 FKBP10 ABCC1 PNPLA2 CSF1R ARSD

4.08e-05198234105470_UP
DrugMinoxidil [38304-91-5]; Down 200; 19.2uM; MCF7; HT_HG-U133A

PIDD1 TPCN1 PIK3CD AP5Z1 HERC6 COMT TTC28 BAZ2A CIAO3 MAP2K5

4.08e-05198234104800_DN
DrugZoxazolamine [61-80-3]; Up 200; 23.8uM; MCF7; HT_HG-U133A

PIDD1 SRCAP GSDME COMT HES2 BAZ2A SIGLEC6 TCF25 HAL PCDH1

4.08e-05198234105390_UP
Drug(-) -Levobunolol hydrochloride [27912-14-7]; Down 200; 12.2uM; PC3; HT_HG-U133A

PIDD1 USP19 TPCN1 ZCCHC14 CIZ1 KCNAB1 ATRN RELB IDS EPAS1

4.26e-05199234104016_DN
DrugYohimbinic acid monohydrate [27801-27-2]; Down 200; 11.2uM; MCF7; HT_HG-U133A

INPP1 PIDD1 SRCAP AP5Z1 KCNAB1 NLE1 PARP12 KDM5A SMG5 MAP2K5

4.26e-05199234102803_DN
DrugArtemisinin [63968-64-9]; Up 200; 14.2uM; MCF7; HT_HG-U133A

PIDD1 MAP3K5 AP5Z1 BAIAP3 TTC28 SPAG6 CSF1R KLF7 R3HDM1 MAP2K5

4.44e-05200234107007_UP
Drugbenzo(a)pyrene-7,8-dione

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.63e-05202344ctd:C076588
DrugChrysenes

AKR1C4 AKR1C1 AKR1C2 AKR1C3

4.63e-05202344ctd:D002911
Drug20 alpha-dihydroprogesterone

AKR1C4 AKR1C1 AKR1C2 AKR1C3 HAL

5.39e-05402345CID000008956
DrugFlunitrazepam

AKR1C4 AKR1C1 AKR1C2 AKR1C3

5.67e-05212344ctd:D005445
Drug2-cyclohexen-1-ol

AKR1C4 AKR1C2 AKR1C3

5.78e-0582343CID000013198
Drugestrone-d4

AKR1C4 AKR1C1 GSDME UGT2B17 COMT IDS ARSD AKR1C3 HAL

6.30e-051682349CID000000698
Drugbenzene dihydrodiol

AKR1C4 AKR1C1 AKR1C2 AKR1C3

6.88e-05222344CID000000418
DrugTat11

KPNA3 KPNA5 TK1

8.60e-0592343CID000480142
DrugFlufenamic Acid

AKR1C4 AKR1C1 AKR1C2 CASR AKR1C3

9.60e-05452345ctd:D005439
DrugGlycyrrhetinic Acid

AKR1C4 AKR1C1 AKR1C2 AKR1C3

9.83e-05242344ctd:D006034
Drugalpha-methylcinnamic acid

AKR1C1 AKR1C3

1.05e-0422342ctd:C510582
Drug(10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE

AKR1C1 AKR1C2

1.05e-0422342DB07768
Drugbaccharin

AKR1C2 AKR1C3

1.05e-0422342ctd:C012764
Drug9,10-phenanthrenequinone

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.16e-04252344ctd:C005399
DrugPregnanolone

AKR1C4 AKR1C1 AKR1C2 AKR1C3

1.16e-04252344ctd:D011280
Drugsulfate

INPP1 MDM2 AP2A1 ABCC8 FBXO7 FES UGT2B17 GRIN3B KPNB1 THOC1 ABCC1 PNPLA2 FMOD COMT RELB IDS NPEPL1 SPAG5 SLC4A1 ARSD TK1 CIAO3 NAPRT INMT NCAN SIGLEC1 HAL DOT1L

1.59e-04129223428CID000001117
DrugFenbendazole [43210-67-9]; Up 200; 13.4uM; MCF7; HT_HG-U133A

SRCAP GGA3 FKBP10 COMT CASR RELB KLF7 SIGLEC6 MAP2K5

1.61e-0419023493888_UP
DrugNSC 60462

AKR1C4 AKR1C1 HAL

1.66e-04112343CID000097943
Drugdihydrocapsaicin

PPRC1 CACNA1H SLC4A1

1.66e-04112343CID000107982
DrugMexiletine hydrochloride [5370-01-4]; Down 200; 18.6uM; MCF7; HT_HG-U133A

CUL7 SRCAP ZCCHC14 HROB CACNA1H PNPLA2 RELB SMG5 ARSD

1.81e-0419323493973_DN
Drugfelodipine; Down 200; 10uM; MCF7; HT_HG-U133A_EA

TPCN1 SIK2 PARP12 ATRN CARD8 PEX26 LIMK2 METTL25B BAZ2A

1.81e-041932349965_DN
DrugConessine [546-06-5]; Down 200; 11.2uM; MCF7; HT_HG-U133A

PIDD1 SRCAP USP19 PIK3CD NCKIPSD NPEPL1 CSF1R SIGLEC6 MAP2K5

1.88e-0419423492792_DN
DrugPF-00562151-00 [351320-12-2]; Up 200; 10uM; MCF7; HT_HG-U133A

BHLHE41 ZCCHC14 PIK3CD KCNAB1 BAIAP3 COMT KLF7 BAZ2A NCAN

1.88e-0419423495954_UP
DrugDO 897/99; Down 200; 8.2uM; HL60; HG-U133A

POGZ AP5Z1 CIZ1 ALDH18A1 RECK KDM5A NUP98 MAP2K5 PHLPP2

1.88e-0419423491728_DN
DrugChlorogenic acid [327-97-9]; Up 200; 11.2uM; MCF7; HT_HG-U133A

BHLHE41 INPP1 PIDD1 CUL7 GGA3 DLC1 AP5Z1 BAIAP3 MAP2K5

1.96e-0419523493282_UP
DrugThalidomide [50-35-1]; Up 200; 15.4uM; MCF7; HT_HG-U133A

DPF1 MDM2 DLC1 CACNA1H PARP12 PLXNA3 SLC4A1 ARSD MAP2K5

1.96e-0419523495990_UP
DrugGuanfacine hydrochloride [29110-48-3]; Up 200; 14.2uM; MCF7; HT_HG-U133A

NDUFA2 MDM2 HNF4A PIK3CD BAIAP3 FKBP10 METTL25B BAZ2A SIGLEC1

1.96e-0419523495256_UP
DrugCyclopenthiazide [742-20-1]; Up 200; 10.6uM; MCF7; HT_HG-U133A

CUL7 HROB AP5Z1 CIZ1 CACNA1H PLXNA3 RELB MAP2K5 PCDH1

1.96e-0419523494813_UP
DrugPiretanide [55837-27-9]; Down 200; 11uM; MCF7; HT_HG-U133A

PIDD1 CUL7 ZCCHC14 SIK2 PARP12 FMOD LIMK2 CSF1R SIGLEC6

1.96e-0419523496828_DN
DrugAC1L3VO5

MDM2 TPCN1 PIK3CD KPNB1 RELB CSF1R EPAS1

2.00e-041162347CID000123015
DrugCefamandole sodium salt [30034-03-8]; Up 200; 8.2uM; MCF7; HT_HG-U133A

DPF1 SRCAP MDM2 GGA3 NLE1 PNPLA2 COMT HES2 BAZ2A

2.03e-0419623494718_UP
Drug6-Hydroxytropinone [5932-53-6]; Up 200; 25.8uM; MCF7; HT_HG-U133A

MDM2 HROB CIZ1 CACNA1H FMOD SIGLEC6 PRKDC MAP2K5 PCDH1

2.03e-0419623494833_UP
DrugMethotrimeprazine maleat salt [7104-38-3]; Down 200; 9uM; MCF7; HT_HG-U133A

PIDD1 SRCAP MDM2 ASTN2 CACNA1H FKBP10 TTC28 CSF1R EPAS1

2.03e-0419623494723_DN
DrugCAY10397; Down 200; 10uM; PC3; HT_HG-U133A

RPS6KB2 CIZ1 AP1G2 RECK ELOA CARD8 PEX26 METTL25B SMARCB1

2.03e-0419623497087_DN
DrugDemecarium bromide [56-94-0]; Down 200; 5.6uM; PC3; HT_HG-U133A

MDM2 USP19 NLE1 FKBP10 FMOD FAAP100 PEX26 METTL25B CIAO3

2.03e-0419623495795_DN
DrugFolinic acid calcium salt [6035-45-6]; Up 200; 7.8uM; PC3; HT_HG-U133A

CIZ1 KCNAB1 RECK NPEPL1 FAAP100 KCNV1 LIMK2 BAZ2A SIGLEC6

2.11e-0419723497401_UP
DiseaseNeoplasms, Hormone-Dependent

AKR1C1 AKR1C2 AKR1C3

4.61e-0732293C0027661
DiseaseMalignant neoplasm of breast

TRIML1 RPS6KB2 NDUFA2 MDM2 GALNT16 GGA3 ZCCHC14 NLE1 ASTN2 DLEC1 THEMIS2 KPNA5 ABCC1 COMT NRCAM PPM1D NUP98 CUBN HELQ TESK1 SPAG6 PBRM1 CSF1R N4BP2

3.74e-06107422924C0006142
DiseaseHermaphroditism

AKR1C1 AKR1C2 AKR1C3

4.56e-0652293C0019269
DiseaseAmbiguous Genitalia

AKR1C1 AKR1C2 AKR1C3

4.56e-0652293C0266362
DiseasePseudohermaphroditism

AKR1C1 AKR1C2 AKR1C3

4.56e-0652293C0033804
DiseaseIntersex Conditions

AKR1C1 AKR1C2 AKR1C3

4.56e-0652293C2930618
DiseaseSex Differentiation Disorders

AKR1C1 AKR1C2 AKR1C3

4.56e-0652293C2930619
DiseaseDisorders of Sex Development

AKR1C1 AKR1C2 AKR1C3

1.58e-0572293C0036875
DiseaseMALE PSEUDOHERMAPHRODITISM: DEFICIENCY OF TESTICULAR 17,20-DESMOLASE

AKR1C4 AKR1C2

6.00e-0522292C1839840
Diseaseautosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)

STRC STRCP1

6.00e-0522292DOID:0110471 (implicated_via_orthology)
Disease46,XY disorder of sex development due to testicular 17,20-desmolase deficiency

AKR1C4 AKR1C2

6.00e-0522292cv:C1839840
Disease46,XY sex reversal 8 (is_implicated_in)

AKR1C4 AKR1C2

6.00e-0522292DOID:0111773 (is_implicated_in)
Disease46,XY SEX REVERSAL 8

AKR1C4 AKR1C2

6.00e-0522292614279
Diseasedevelopmental and epileptic encephalopathy 33 (implicated_via_orthology)

EEF1A1 EEF1A1P5

1.79e-0432292DOID:0080463 (implicated_via_orthology)
Diseaseplatelet component distribution width

ARMC3 LRRK2 PSMD2 DLC1 CRLF3 DLEC1 BRAT1 THEMIS2 SUPT20H CFAP73 HEATR4 CUBN KLF7 BAZ2A SIGLEC1 EPAS1

2.97e-0475522916EFO_0007984
Diseaseobsolete_red blood cell distribution width

LRRC24 BIRC6 VSTM4 RBM27 FBXO7 GRIN3B SPSB2 KPNB1 THEMIS2 ABCC1 TTC28 HECTD4 RELB SMG5 SLC4A1 EEF1A1 EEF1A1P5 LIMK2 METTL25B PBRM1 LRRC25 TK1 R3HDM1

3.55e-04134722923EFO_0005192
DiseaseEndometrial Stromal Sarcoma

NUTM2A NUTM2B

5.91e-0452292C0206630
Diseaseage at menopause

BIRC6 PARL KPNA3 NRCAM TTC28 HELQ TCF25 PRKDC ABHD12

6.27e-043022299EFO_0004704
Diseasegamma-glutamylglutamine measurement

ASTN2 ABCC1 PPM1D

6.37e-04222293EFO_0021138
Diseasesensory peripheral neuropathy, remission

DLC1 DLEC1 CACNB4

7.28e-04232293EFO_0009785, MONDO_0002321
Diseasealcohol use disorder (implicated_via_orthology)

DPF1 HNF4A PIK3CD CIZ1 UNC79 KDM5A PBRM1

8.61e-041952297DOID:1574 (implicated_via_orthology)
DiseaseClear cell sarcoma of kidney

NUTM2B NUTM2E

8.81e-0462292C0334488
Diseasecortolone glucuronide (1) measurement

AKR1C2 AKR1C3

8.81e-0462292EFO_0800552
DiseaseIdiopathic generalized epilepsy

CACNB4 CASR

8.81e-0462292C0270850
DiseaseEpilepsy, Generalized

CACNA1H CACNB4

8.81e-0462292C0014548
DiseaseIdiopathic generalized epilepsy

CACNA1H CACNB4

8.81e-0462292cv:C0270850
Diseaselevel of Sterol ester (27:1/16:0) in blood serum

HNF4A RELB NCAN

1.05e-03262293OBA_2045191
DiseaseEndometrial Neoplasms

AKR1C1 PLXNA3 ABCC9 AKR1C3

1.08e-03582294C0014170
Diseaseheparin cofactor 2 measurement

DLC1 PHLPP2

1.23e-0372292EFO_0008150
Diseaseprostate-specific antigen measurement, disease progression measurement

NGEF SPHKAP

1.23e-0372292EFO_0008336, EFO_0020660
Diseasehereditary spastic paraplegia (is_implicated_in)

AP5Z1 ALDH18A1

1.23e-0372292DOID:2476 (is_implicated_in)
DiseaseMASA syndrome (implicated_via_orthology)

CHL1 NRCAM

1.23e-0372292DOID:0060246 (implicated_via_orthology)
Diseasenon-high density lipoprotein cholesterol measurement

HNF4A DLC1 XRN1 UGT2B17 ASCC3 KPNB1 PLXNA3 COMT NRDC HEATR5A PRKAG3 PBRM1 CSF1R NCAN

1.46e-0371322914EFO_0005689
DiseaseFamilial hyperinsulinism

HNF4A ABCC8

1.63e-0382292cv:C3888018
Diseaseage at onset, coronary stenosis

DLC1 DLEC1

2.08e-0392292EFO_0004847, MONDO_0006715
DiseaseEndometrial Carcinoma

AKR1C1 PLXNA3 ABCC9 AKR1C3

2.41e-03722294C0476089
Diseaselymphocyte count

IL16 AKR1C4 VSTM4 PIK3CD CRLF3 MCM3AP ALDH18A1 CORO7 PARP12 KPNA3 THEMIS2 ABCC1 TTC28 PCDHGA6 HECTD4 ARHGEF18 SLC4A1 PRKAG3 MST1R PBRM1 SIGLEC1 RNF39

2.44e-03146422922EFO_0004587
Diseaselow density lipoprotein cholesterol measurement, C-reactive protein measurement

HNF4A HECTD4 NCAN

2.51e-03352293EFO_0004458, EFO_0004611
DiseaseAmphetamine-Related Disorders

ASTN2 COMT CUBN MAP2K5

2.79e-03752294C0236733
DiseaseAmphetamine Abuse

ASTN2 COMT CUBN MAP2K5

2.79e-03752294C0236807
DiseaseAmphetamine Addiction

ASTN2 COMT CUBN MAP2K5

2.79e-03752294C0236804
Diseasepulse pressure measurement

NCKAP1 POGZ SRCAP SSPOP TRIM66 DLC1 RPTOR FES DLEC1 CORO7 TTC28 KDM5A RNF213 ABCC9 NBEA HEATR5A MEI1 PBRM1 MALRD1 CPXM1 DOT1L

2.91e-03139222921EFO_0005763
DiseaseX-11315 measurement

MROH6 NAPRT

3.15e-03112292EFO_0021223
DiseaseT-cell acute lymphoblastic leukemia (is_implicated_in)

NUP98 AKR1C3

3.15e-03112292DOID:5603 (is_implicated_in)
Diseaseforced expiratory volume, body mass index

DIS3L2 HECTD4

3.15e-03112292EFO_0004314, EFO_0004340
Diseaseneutropenia, response to gemcitabine

DLC1 DLEC1

3.15e-03112292GO_0036272, MONDO_0001475
Diseasehepatocyte growth factor-like protein measurement

USP19 NCKIPSD DNAH1

3.19e-03382293EFO_0008154
Diseasenitric oxide exhalation measurement

DLC1 DLEC1 SPSB2

3.19e-03382293EFO_0005536
Diseaseplatelet crit

DPF1 BHLHE41 INPP1 LRRK2 VSTM4 RBM27 DQX1 THEMIS2 TTC28 HEATR4 CUBN EEF1A1P5 TGM3 FBXL16 NCAN DOT1L

3.28e-0395222916EFO_0007985
DiseaseSarcomatoid Renal Cell Carcinoma

LRRK2 PIDD1 CUL7 PBRM1 EPAS1

3.29e-031282295C1266043
DiseaseChromophobe Renal Cell Carcinoma

LRRK2 PIDD1 CUL7 PBRM1 EPAS1

3.29e-031282295C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

LRRK2 PIDD1 CUL7 PBRM1 EPAS1

3.29e-031282295C1266044
DiseasePapillary Renal Cell Carcinoma

LRRK2 PIDD1 CUL7 PBRM1 EPAS1

3.29e-031282295C1306837
DiseaseRenal Cell Carcinoma

LRRK2 PIDD1 CUL7 PBRM1 EPAS1

3.29e-031282295C0007134
Diseasehyperinsulinism (is_implicated_in)

ABCC8 PARL

3.76e-03122292DOID:2018 (is_implicated_in)
DiseaseN-acetylputrescine measurement

TUBGCP6 HDAC10

3.76e-03122292EFO_0800127
DiseaseCombined immunodeficiency

ADA2 PIK3CD PRKDC

3.96e-03412293C0494261
Diseasemale infertility (implicated_via_orthology)

CFAP47 TCTE1

4.42e-03132292DOID:12336 (implicated_via_orthology)
DiseaseAutistic Disorder

INPP1 CUL7 ASTN2 CACNA1H COMT NRCAM NBEA

4.44e-032612297C0004352
Diseasedilated cardiomyopathy (is_implicated_in)

CACNB4 ABCC9 CTF1

4.53e-03432293DOID:12930 (is_implicated_in)
Diseasegestational age

PNMA5 DLC1 KCNAB1 DLEC1 MALRD1

4.53e-031382295EFO_0005112
DiseaseNeoplastic Cell Transformation

MDM2 AKR1C1 AKR1C2 AKR1C3 EPAS1

4.67e-031392295C0007621
Diseasebody weights and measures, parental genotype effect measurement

FES EPAS1

5.13e-03142292EFO_0004324, EFO_0005939
DiseaseMaturity onset diabetes mellitus in young

HNF4A ABCC8

5.13e-03142292C0342276
Disease5alpha-androstan-3alpha,17alpha-diol monosulfate measurement

AKR1C4 UGT2B17

5.13e-03142292EFO_0800283
Diseaselipid measurement, lipoprotein measurement

AKR1C4 HNF4A KPNB1 NCAN

5.36e-03902294EFO_0004529, EFO_0004732
Diseaseneurodegenerative disease (implicated_via_orthology)

LRRK2 PSMD2 GGA3 NRDC PRKAG3

5.58e-031452295DOID:1289 (implicated_via_orthology)
Diseasenasopharynx carcinoma (is_implicated_in)

MST1R CSF1R

5.89e-03152292DOID:9261 (is_implicated_in)
DiseaseNeurodevelopmental Disorders

NCKAP1 POGZ SRCAP PPM1D

6.02e-03932294C1535926
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

LRRK2 PIDD1 CUL7 PBRM1 EPAS1

6.07e-031482295C0279702
Diseaselevel of Sterol ester (27:1/18:1) in blood serum

HNF4A RELB

6.70e-03162292OBA_2045195
Diseaseresponse to methotrexate

AKR1C1 AKR1C2

6.70e-03162292GO_0031427
DiseaseMonogenic diabetes

HNF4A ABCC8

6.70e-03162292C3888631
Diseaseage at menarche

FAM120B AKR1C4 TRIM66 RPTOR ASCC3 UNC79 TTC28 HELQ NT5DC2 MAP2K5 EPAS1

7.03e-0359422911EFO_0004703
Diseaseunipolar depression, bipolar disorder

GSDME ASTN2 ASCC3 TUBGCP6 NCAN

7.55e-031562295EFO_0003761, MONDO_0004985
DiseaseInfluenza

HERC6 PARP12 SIGLEC1

7.71e-03522293C0021400

Protein segments in the cluster

PeptideGeneStartEntry
VLGCFSPAEQELLPL

PTRH1

176

Q86Y79
VHCLLPPLESLATVE

PPP2R1A

86

P30153
LLLCSAPSAAPEALV

ALKBH4

201

Q9NXW9
LCQEVEVAIPLPARS

ALKBH4

226

Q9NXW9
NSPVLLEDPVLCALA

AKR1C4

231

P17516
DPSAVLPLDCLLAFV

CCAR2

696

Q8N163
QLSPICPEERLLAEN

EPAS1

541

Q99814
AQLLPALCAVLVDPR

BRAT1

6

Q6PJG6
ALCAVLVDPRQPVAD

BRAT1

11

Q6PJG6
DEEPCLPRTLASLAL

ARHGEF18

101

Q6ZSZ5
APAARDSLPVLLFLC

ARSD

11

P51689
QRELSLLCPGDSPAV

ACTL7B

356

Q9Y614
PLSELPIELESLECP

CCDC148

206

Q8NFR7
ILDESLLETCPIQSP

BIRC6

4056

Q9NR09
AAALAALPPLLDAVC

CTF1

91

Q16619
GLLEERPALCLSPQA

PRKAG3

151

Q9UGI9
LEGFLDCSLVLPPTD

SLC4A1

311

P02730
VLPRPLLSCTQALDD

BAIAP3

836

O94812
APCLERAGQKLEPLA

BHLHE41

201

Q9C0J9
DEVLRLCDPSAPLAF

ADGRB1

121

O14514
NSPVLLEDPVLCALA

AKR1C3

231

P42330
PPCLEILTNGFAVLE

AFTPH

176

Q6ULP2
LPCGLLLDELLASPE

DUX4L4

366

P0CJ87
LQEVCLRPSADPIFE

BAZ2A

1476

Q9UIF9
EPLLPLQCGETDLDL

CASR

1011

P41180
LPEGPVLEALLCAET

DPF1

111

Q92782
VLEPVCDDLVSGLSP

GSDME

326

O60443
LQAFLESCPPDLRAD

AP1G2

386

O75843
LNIECLRDFLTPPLL

AP2A1

826

O95782
ILACPVSDPNDLFLE

CPXM1

271

Q96SM3
PEVDVFVLLACPLGA

DPH2

331

Q9BQC3
DACSLQPDIDLLPFG

ABCC9

786

O60706
VDLLQATLGLPACPE

AP5Z1

66

O43299
PLKELCLQEPSDLRA

ARMC3

586

Q5W041
LDLASEEPERLPCLQ

ASB6

141

Q9NWX5
LLQLKSCVPPDDALS

DOT1L

656

Q8TEK3
EPCARLLEQALELLP

CFAP73

141

A6NFT4
DFSSEVLECLPQGLP

DIS3L2

346

Q8IYB7
CEIGFIPSPLRLENI

CACNB4

146

O00305
ADGLLVIPLPVEEQC

ASTN2

811

O75129
AALVRPEASVPCLIA

ADAMTS13

1056

Q76LX8
VGPQLRATCPLLAEL

C17orf113

281

A0A1B0GUU1
CLALIEPITSPIENI

CKAP2

466

Q8WWK9
SDPEDCLLLTRIPKV

GALNT16

166

Q8N428
DFVLNCEILPPLLEL

KPNA5

206

O15131
LKLVRSLAVCEESPP

R3HDM1

76

Q15032
LLEPICDADPSALAN

RBM27

16

Q9P2N5
LQRLTDGVCSEPLPF

RELB

381

Q01201
LLSPTDDLKNCIPLD

RECK

461

O95980
ALIVRLPFCGPNELD

OR4M2B

161

A0A0X1KG70
LLLLARPASCAPDEL

KIAA1549

51

Q9HCM3
QIALLDIDICGPSIP

NUBP1

86

P53384
ISCPLLILHAEDDPV

ABHD12

321

Q8N2K0
PARLNEALLEACVEP

PNPLA2

301

Q96AD5
TTDPAVILDLLPLCR

TCTE1

171

Q5JU00
ECLERNPETGLDLPQ

INPP1

336

P49441
DELCPLIVPNLGVAV

NUP98

1231

P52948
LVTCSIPRSLPFELE

PCDHGA6

381

Q9Y5G7
FLSCRPTEIPENDIL

PBRM1

1241

Q86U86
PTEIPENDILLCESR

PBRM1

1246

Q86U86
PADAPLCLRLASLIE

FMOD

361

Q06828
LPILVKCLERDDNPS

KPNA3

116

O00505
TPCPSILELEELLRA

DUSP13

16

Q6B8I1
EILLLECFAEGLPTP

CHL1

256

O00533
ALEETDPLLLCSPAT

NCKAP5L

196

Q9HCH0
DPEVVSSCPDLQLRL

INTS1

1626

Q8N201
NVLSLECIAEGLPTP

NRCAM

286

Q92823
PAVLPLADCVLTLLA

INMT

151

O95050
LPACRVLEPAVSARL

HES2

101

Q9Y543
DPDCLPRTLDFGLNV

LIMK2

546

P53671
PIAERLGCTLPQLAV

KCNAB1

346

Q14722
LPLLLRESDSLEPSC

LRRC25

11

Q8N386
PLLLLLLPCEAEAAA

ATRN

71

O75882
LRALAPSAECPIAEE

MCM3AP

1276

O60318
TLDTSLGCLVPLLDP

CORO7

256

P57737
PAFCELPLDDQVALL

HNF4A

206

P41235
LAAVPSPLELCDDAN

KCNV1

81

Q6PIU1
EEILPGFILCDPSNL

GSPT2

501

Q8IYD1
ENEAVLLPSGELLCP

PLXNA3

581

P51805
LLQCIVDEDSPVLPV

MAP2K5

371

Q13163
ALIVRLPFCGPNELD

OR4M1

161

Q8NGD0
ALIVRLPFCGPNELD

OR4M2

161

Q8NGB6
QLPGDPCILEFEVSI

PCDH1

126

Q08174
SEDPLLNLVSPLGCE

NPEPL1

491

Q8NDH3
ILCLLVVRFDPASPS

PEX26

261

Q7Z412
DSLPEVPLLVDVPCL

CRLF3

141

Q8IUI8
VPLLVDVPCLSAQLD

CRLF3

146

Q8IUI8
ALRQLEECVGTIPPA

CUL7

121

Q14999
QEALSVFLLLPECPV

HERC6

476

Q8IVU3
TCGQEARELLPLLLP

IL16

631

Q14005
PASLQVPEITFCEIL

MYRFL

691

Q96LU7
CAEPPRLALQSLLDV

LRRC24

236

Q50LG9
PPEIGCLENLTSLDV

LRRK2

1261

Q5S007
TAPSEALGLPDLDLC

HROB

66

Q8N3J3
DEELLCLGLADPAPN

GGA3

391

Q9NZ52
FAPNAPDVLSCLELR

TUBGCP6

1591

Q96RT7
LVPTARKALCDPLEE

GCN1

2006

Q92616
RLDPLLLPVEAAICE

KLF7

76

O75840
RDVVCALLPRSLPAD

MROH6

186

A6NGR9
PTALCEELLLPLENP

METTL25B

231

Q96FB5
EELLLPLENPCQGRA

METTL25B

236

Q96FB5
PEPLEENCAKALTLR

PPM1D

471

O15297
AANPPLCSVLLEDAR

DPY19L2

726

Q6NUT2
DAADPRVACLLNVPI

HECTD4

3496

Q9Y4D8
ALSPEVLCSLALPEG

LBX2

156

Q6XYB7
IPVDPDACILPDAAL

FAAP100

116

Q0VG06
LPACLLRDVAQEALG

TK1

76

P04183
PPDRVEAACQAVLEL

DQX1

241

Q8TE96
ASQPLIDLPLIDFCD

GTSE1

641

Q9NYZ3
LPVRLPEGEALQCLT

KDM5A

1236

P29375
LSSAAGLPCEIDPAL

NCKAP1

961

Q9Y2A7
GLPCEIDPALVVALS

NCKAP1

966

Q9Y2A7
ESRPDCLPQVAALAI

ALDH18A1

481

P54886
ACALELLPDPGVSLV

MEI1

46

Q5TIA1
APERVVLAASPLRLC

PARP12

61

Q9H0J9
IDDIRFENCTLPLPA

MALRD1

806

Q5VYJ5
SPGARLITIEINPDC

COMT

131

P21964
LLADNVICPGAPDFL

COMT

216

P21964
LTQLCGDEKPPLIRS

CUBN

1236

O60494
PCLLENVGEELDPAL

DNAH1

3276

Q9P2D7
QDALLPCLLTDPVLE

CSF1R

121

P07333
DAVQLETLELPPGCV

FKBP10

266

Q96AY3
LLCVALGQLDRPPDL

HDAC10

506

Q969S8
IERLCNPSLSELPAF

HAL

471

P42357
ALVILSELPAVCSPE

HEATR5A

1726

Q86XA9
PEDETLPINVICGIL

SLC25A30

101

Q5SVS4
LNTCLQELGPLEPEE

DSCC1

226

Q9BVC3
SVLEPVLERCTPDQL

ELOA

601

Q14241
GDLICLILQDDIPAP

FBXO7

71

Q9Y3I1
TTLLEALDCILPPTR

EEF1A1

226

P68104
RLNDEGPFLILCPLS

CHD1L

91

Q86WJ1
LPEVLLPALEAALCD

HEATR4

526

Q86WZ0
EAEPLLFRAVPECQL

CARD8

96

Q9Y2G2
PSERPALCFLLLAVA

ADA2

6

Q9NZK5
AACVPVVNDISPRLL

DNAH14

1976

Q0VDD8
PLLQCLIEGLSAEPR

KPNB1

451

Q14974
LTDDSPVDLLCAPVP

MARF1

1616

Q9Y4F3
TTLLEALDCILPPTR

EEF1A1P5

226

Q5VTE0
RLLLTQPGCDPAILD

KANK3

746

Q6NY19
ILFCADLPSLIQEGP

C19orf54

116

Q5BKX5
NLLCPVDVLDVPEGT

IDS

181

P22304
VEVQPLLLSDSPECL

HELQ

61

Q8TDG4
LLEEAVPLSCALPKV

CLIP3

261

Q96DZ5
LNCVTIALERPDIDP

CACNA1H

1306

O95180
DLIPEQPCSGVLSEL

DLEC1

1486

Q9Y238
QEEGLAAVCTPALRP

SCAP

921

Q12770
RTADPAILPNILICL

SLFN13

871

Q68D06
PLIGLIPSCQLEIES

CFAP47

131

Q6ZTR5
VLRAPAALPALCDLL

IPO4

31

Q8TEX9
ALQRSPETPLEICLV

PPRC1

806

Q5VV67
PGFENIELTPLAAIC

FAM171B

241

Q6P995
DLPLLACLLGNDIIP

FAM120B

221

Q96EK7
LLGEPEAAVSPLLCL

PIDD1

506

Q9HB75
IPALLPLACADTSLA

OR10D3

181

Q8NH80
CEELTAVLTPPQLLG

PARL

26

Q9H300
IQACALLPDLEILPS

ABCC1

741

P33527
LVAVKSCRETLPPDL

FES

586

P07332
NFELLLGPICLPLVD

MAP3K5

241

Q99683
PDTEALSCFLIPVLR

NUTM2A

351

Q8IVF1
PDTEALSCFLIPVLR

NUTM2B

351

A6NNL0
PDTEALSCFLIPVLR

NUTM2E

351

B1AL46
PVPAAVLLGCDIARA

GRIN3B

231

O60391
KANPDLPILIRECSD

NDUFA2

46

O43678
VSLCPQGLVDPADLA

RNF186

116

Q9NXI6
ELELTNCPGATPELF

FBXL16

451

Q8N461
TINLLKPLPVEDSDC

FNDC8

66

Q8TC99
LVCNALLAQEDPLPL

NLE1

46

Q9NVX2
RSLLVINFDLEPECP

SPHKAP

1606

Q2M3C7
EQLLCGRPPDLTALS

SPAG5

416

Q96R06
AGAVPLLVLCIQEPE

SPAG6

166

O75602
APLLVLCPSRAELDR

PLEKHN1

166

Q494U1
TLLLDECPLPTKDAL

RSPRY1

161

Q96DX4
ILATAEPLCLDPSVA

SUPT20HL1

201

Q3ZLR7
PLIAKADCLVPSEIR

SEPTIN5

186

Q99719
EVAPRQEDLVPCASL

SSPOP

31

A2VEC9
QDLLEGCELPDLPSS

SMG5

711

Q9UPR3
PALALLREGCPADTS

TGFBR3L

121

H3BV60
PELSPADACPLAELR

RPS6KB2

21

Q9UBS0
PEPENSALLRCALGV

PSMD2

241

Q13200
ALALPPLATEGAECL

POGZ

926

Q7Z3K3
ALEGPENCLFPRLIS

NBEA

2816

Q8NFP9
LAELVALPCLFTLQP

NCAN

51

O14594
VESSLPLNAIEPCVI

MDM2

426

Q00987
IAQLELDPKCRGLPF

NGEF

391

Q8N5V2
LLTLDVELPPVCSDI

PTTG3P

186

Q9NZH4
SPLLCPERQEDILDS

RUFY4

136

Q6ZNE9
QEDVEPFLCILLPAT

SMIM28

46

A0A1B0GU29
SLPVLEGQALRLLCD

SIGLEC6

261

O43699
DPLALSELPGLFDCE

SIK2

896

Q9H0K1
VQELARLDPSLCDPL

SHROOM1

546

Q2M3G4
RTADPAILPNVLICL

SLFN11

871

Q7Z7L1
ILCDDLDLNPLTFVP

SMARCB1

221

Q12824
TNLPLGLRPEAELCA

SRCAP

2541

Q6ZRS2
ELPLCVSESNGLELP

SRCAP

2641

Q6ZRS2
EFLDTPCTNRGLPLL

DLC1

256

Q96QB1
AERLCGEASLQAVPP

STRC

481

Q7RTU9
PLACFLSPEELQSLV

STRC

931

Q7RTU9
GLPLDTTEQLPDLCV

NCKIPSD

541

Q9NZQ3
ALVLCLNVGVDPPDV

RPTOR

61

Q8N122
ACISLPLLPRIEEAL

SNAI3

66

Q3KNW1
ILATAEPLCLDPSVA

SUPT20HL2

201

P0C7V6
LFSNPLDEPVRDCVL

TGM3

616

Q08188
VIEACSLQPDIDILP

ABCC8

801

Q09428
NSPVLLEDPVLCALA

AKR1C1

231

Q04828
NSPVLLEDPVLCALA

AKR1C2

231

P52895
ERALALPEICTQCPG

ATRAID

26

Q6UW56
LLLLPASDDVCTAPG

ANKFN1

721

Q8N957
ELLDLQPLPITALGC

ASCC3

1301

Q8N3C0
VSLPDLEPAPLDSLC

CIAO3

286

Q9H6Q4
CLLSLLPVPRDVLET

CIZ1

631

Q9ULV3
LELLDQRGCPPNFLE

PNMA5

306

Q96PV4
RDLSNINCEELGPLP

SMURF2

286

Q9HAU4
RLCLTLGIPQATDPD

RNF213

2376

Q63HN8
PCFLLLALVLVPSDA

SIRPB2

16

Q5JXA9
LLVEADEQLCIPPLN

USP19

201

O94966
DTDNDLVPPLELCIR

MINDY4

726

Q4G0A6
SCNDLTEILIPEALP

PHLPP2

721

Q6ZVD8
FEQLCASLLARVEPP

HSPA4L

306

O95757
LVTLPCLQPEVDGEA

PRX

831

Q9BXM0
VLQDPALKDLVLTCP

THEMIS2

181

Q5TEJ8
PDLSCPEGLEELLSA

SPSB2

21

Q99619
LATAEPLCLDPSIAV

SUPT20H

201

Q8NEM7
RVIFSIPCEPNLDAL

XRN1

886

Q8IZH2
DLIPCSDLPSLDAIG

UPK3A

106

O75631
SPLLADCIIPITDIR

NRDC

1121

O43847
DSAAALLICLPEVAP

PIK3CD

466

O00329
LCDALLISQDSPPVL

SLFN12

441

Q8IYM2
PLLLILDRCDDAITP

VPS45

211

Q9NRW7
GQLCEPLPSLAESRA

NAPRT

481

Q6XQN6
TLVGDDCPLPFLLLA

TESK1

276

Q15569
GLLLCRVDSDPPAQL

SIGLEC1

1001

Q9BZZ2
NRELTDLLPPEVCSL

NT5DC2

36

Q9H857
TQLCLLFPPDESIDL

YTHDC1

486

Q96MU7
IAPGDERQCLPSLDL

PRKDC

1491

P78527
LERSEPLLLQCPEAT

TRIML1

251

Q8N9V2
LLSLCEAPAVPALRL

TPCN1

121

Q9ULQ1
ENLEKLIPCLAGPDA

ZCCHC14

151

Q8WYQ9
DGESISDCPPLQELL

TTC28

1591

Q96AY4
SDCPPLQELLLTAAD

TTC28

1596

Q96AY4
DILLNPVLALSFCPD

VWA5B2

326

Q8N398
SAPEPRVLVCLGALL

VSIG10

6

Q8N0Z9
AERLCGEASLQAVPP

STRCP1

481

A6NGW2
PLACFLSPEELQSLV

STRCP1

931

A6NGW2
CTDLRPLDILAEVVP

TSPEAR

26

Q8WU66
LLARAPAPEVCAALN

VSTM4

11

Q8IW00
LPLFQLVLSDLPCEE

TMEM207

21

Q6UWW9
EEPLNSVLFLRPISC

LCMT2

556

O60294
ARLPRDTVCLDTLPA

TREX2

136

Q9BQ50
LCPRDGADPSLENAL

TRIM66

781

O15016
KVLVLDPALPALVSC

MST1R

121

Q04912
VLLPLLESCSVRPDA

TCF25

461

Q9BQ70
PCGELLAELLNIPFL

UGT2B17

156

O75795
STPFVLLGDVLDCLP

THOC1

91

Q96FV9
PGLVERLEQLATCPL

RNF39

76

Q9H2S5
CLLPFLNDDILSTLP

UNC79

161

Q9P2D8
LTIDCLELALPPELA

N4BP2

1371

Q86UW6