Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	VN1R3 GPR6 CYSLTR2 OR2A7 OR4K17 OR1B1 OR4C11 OR2G3 OR4E1 OR2AG2 ADGRG1 OR2A5 OPN1SW MRGPRX1 GPR149 OR2A4 OR1E3 HRH2 MRGPRX4 PTGDR2	1.83e-06	884	134	20	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	MPL VN1R3 GPR6 CYSLTR2 OR2A7 OR4K17 OR1B1 OR4C11 OR2G3 OR4E1 OR2AG2 ADGRG1 OR2A5 GRIN1 OPN1SW MRGPRX1 GPR149 OR2A4 OR1E3 HRH2 MRGPRX4 FGFR1 PTGDR2	3.24e-05	1353	134	23	GO:0004888
GeneOntologyMolecularFunction	complement component C1q complex binding	APCS C4A C4B	3.43e-05	10	134	3	GO:0001849
GeneOntologyMolecularFunction	neuropeptide binding	MRGPRX1 GPR149 MRGPRX4 PTGDR2	1.08e-04	37	134	4	GO:0042923
GeneOntologyMolecularFunction	gap junction channel activity	GJC1 GJB2 GJA10	6.10e-04	25	134	3	GO:0005243
GeneOntologyMolecularFunction	opsonin binding	APCS C4A C4B	6.10e-04	25	134	3	GO:0001846
GeneOntologyMolecularFunction	olfactory receptor activity	OR2A7 OR4K17 OR1B1 OR4C11 OR2G3 OR4E1 OR2AG2 OR2A5 OR2A4 OR1E3	6.68e-04	431	134	10	GO:0004984
GeneOntologyMolecularFunction	protein-cysteine S-palmitoyltransferase activity	ZDHHC16 ZDHHC12 ZDHHC23	6.86e-04	26	134	3	GO:0019706
GeneOntologyMolecularFunction	protein-cysteine S-acyltransferase activity	ZDHHC16 ZDHHC12 ZDHHC23	6.86e-04	26	134	3	GO:0019707
GeneOntologyMolecularFunction	S-acyltransferase activity	ZDHHC16 ZDHHC12 ZDHHC23	1.05e-03	30	134	3	GO:0016417
GeneOntologyMolecularFunction	nodal binding	LEFTY2 LEFTY1	1.22e-03	8	134	2	GO:0038100
GeneOntologyMolecularFunction	complement binding	APCS C4A C4B	1.27e-03	32	134	3	GO:0001848
GeneOntologyMolecularFunction	ATPase activator activity	TOR1AIP2 GTF2H4 MYBPC3	1.27e-03	32	134	3	GO:0001671
GeneOntologyMolecularFunction	gap junction channel activity involved in cell communication by electrical coupling	GJC1 GJB2	1.56e-03	9	134	2	GO:1903763
GeneOntologyBiologicalProcess	sensory perception	VN1R3 OR2A7 OR4K17 OR1B1 OR4C11 OR2G3 OR4E1 TSPEAR GJC1 OR2AG2 CDH23 EML2 OR2A5 GRIN1 OPN1SW LRIT3 GJB2 OR2A4 PGAP1 OR1E3 PAX2 FGFR1 GJA10 SLC38A8 IMPG2	2.68e-08	1072	135	25	GO:0007600
GeneOntologyBiologicalProcess	visual perception	GJC1 CDH23 EML2 OPN1SW LRIT3 PAX2 GJA10 SLC38A8 IMPG2	2.11e-05	230	135	9	GO:0007601
GeneOntologyBiologicalProcess	sensory perception of light stimulus	GJC1 CDH23 EML2 OPN1SW LRIT3 PAX2 GJA10 SLC38A8 IMPG2	2.34e-05	233	135	9	GO:0050953
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	MPL VN1R3 GPR6 CYSLTR2 OR2A7 OR4K17 OR1B1 OR4C11 OR2G3 OR4E1 OR2AG2 ADGRG1 OR2A5 OPN1SW EDN2 ORAI1 MRGPRX1 GPR149 OR2A4 OR1E3 HRH2 MRGPRX4 PTGDR2	3.57e-05	1395	135	23	GO:0007186
GeneOntologyBiologicalProcess	negative regulation of nodal receptor complex assembly	LEFTY2 LEFTY1	4.25e-05	2	135	2	GO:1900124
GeneOntologyBiologicalProcess	regulation of nodal receptor complex assembly	LEFTY2 LEFTY1	4.25e-05	2	135	2	GO:1900123
GeneOntologyBiologicalProcess	nodal receptor complex assembly	LEFTY2 LEFTY1	4.25e-05	2	135	2	GO:0038099
GeneOntologyBiologicalProcess	protein lipidation	ZDHHC16 PIGZ ZDHHC12 ZDHHC23 PGAP1 PIGW	5.35e-05	101	135	6	GO:0006497
GeneOntologyBiologicalProcess	cytosolic transport	GAK ANKFY1 VPS13C HEATR5A ASB14 HEATR5B DOP1A	5.95e-05	150	135	7	GO:0016482
GeneOntologyBiologicalProcess	lipoprotein biosynthetic process	ZDHHC16 PIGZ ZDHHC12 ZDHHC23 PGAP1 PIGW	7.02e-05	106	135	6	GO:0042158
GeneOntologyBiologicalProcess	Golgi to lysosome transport	GAK ANKFY1 ASB14	7.47e-05	13	135	3	GO:0090160
GeneOntologyBiologicalProcess	maintenance of protein location in membrane	ANK3 CCDC88A	1.27e-04	3	135	2	GO:0072658
GeneOntologyBiologicalProcess	maintenance of protein location in plasma membrane	ANK3 CCDC88A	1.27e-04	3	135	2	GO:0072660
GeneOntologyBiologicalProcess	post-Golgi vesicle-mediated transport	GAK ANKFY1 ANK3 VPS13C ASB14 DOP1A	1.33e-04	119	135	6	GO:0006892
GeneOntologyCellularComponent	mitotic spindle midzone	OR2A7 TTC28 OR2A4 EML1	2.94e-06	16	136	4	GO:1990023
GeneOntologyCellularComponent	endoplasmic reticulum membrane	TOR1AIP2 CDS1 MBOAT7 ERAP1 VPS13C CFTR ZDHHC16 OR4E1 GJC1 GRIN1 SELENON PIGZ LRIT3 GGCX ZDHHC12 UBXN4 MSMO1 PARP16 PGAP1 PEX16 PIGW	9.31e-05	1293	136	21	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	TOR1AIP2 CDS1 MBOAT7 ERAP1 VPS13C CFTR ZDHHC16 OR4E1 GJC1 GRIN1 SELENON PIGZ LRIT3 GGCX ZDHHC12 UBXN4 MSMO1 PARP16 PGAP1 PEX16 PIGW	9.94e-05	1299	136	21	GO:0098827
GeneOntologyCellularComponent	spindle midzone	OR2A7 TTC28 OR2A4 EML1	1.31e-04	40	136	4	GO:0051233
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	TOR1AIP2 CDS1 MBOAT7 ERAP1 VPS13C CFTR ZDHHC16 OR4E1 GJC1 GRIN1 SELENON PIGZ LRIT3 GGCX ZDHHC12 UBXN4 MSMO1 PARP16 PGAP1 PEX16 PIGW	1.34e-04	1327	136	21	GO:0042175
GeneOntologyCellularComponent	mitotic spindle pole	OR2A7 TTC28 OR2A4 EML1	1.74e-04	43	136	4	GO:0097431
GeneOntologyCellularComponent	connexin complex	GJC1 GJB2 GJA10	3.79e-04	22	136	3	GO:0005922
MousePheno	abnormal left renal vein morphology	LEFTY2 LEFTY1	4.86e-05	2	98	2	MP:0011327
MousePheno	abnormal renal vein morphology	LEFTY2 LEFTY1	4.86e-05	2	98	2	MP:0011323
MousePheno	decreased soleus weight	SELENON IFRD1 SACS	5.29e-05	11	98	3	MP:0009426
MousePheno	abnormal bronchus morphology	ANK3 CFTR LEFTY2 LEFTY1	7.95e-05	33	98	4	MP:0002264
MousePheno	abnormal pulmonary alveolar sac morphology	GAK SELENON EDN2	9.08e-05	13	98	3	MP:0010902
MousePheno	abnormal soleus weight	SELENON IFRD1 SACS	9.08e-05	13	98	3	MP:0020165
MousePheno	abnormal electroretinogram waveform feature	CDH23 LRIT3 EPG5 EML1 SLC38A8 IMPG2	9.87e-05	106	98	6	MP:0012029
MousePheno	enhanced female fertility	INHA GPR149	1.45e-04	3	98	2	MP:0031424
MousePheno	decreased circulating copper level	ATP7A STEAP3	1.45e-04	3	98	2	MP:0006349
MousePheno	abnormal kidney venous blood vessel morphology	LEFTY2 LEFTY1	1.45e-04	3	98	2	MP:0011311
MousePheno	abnormal respiratory conducting tube morphology	ATP7A ANK3 CFTR LEFTY2 LEFTY1	2.29e-04	79	98	5	MP:0004391
MousePheno	decreased b-wave amplitude	LRIT3 EPG5 EML1 SLC38A8 IMPG2	2.72e-04	82	98	5	MP:0012144
MousePheno	increased copper level	ATP7A STEAP3	2.89e-04	4	98	2	MP:0014539
MousePheno	abnormal large intestine placement	LEFTY2 LEFTY1	2.89e-04	4	98	2	MP:0003284
MousePheno	abnormal circulating copper level	ATP7A STEAP3	2.89e-04	4	98	2	MP:0006348
MousePheno	abnormal b-wave shape	LRIT3 EPG5 EML1 SLC38A8 IMPG2	3.22e-04	85	98	5	MP:0012035
MousePheno	abnormal b-wave amplitude	LRIT3 EPG5 EML1 SLC38A8 IMPG2	3.22e-04	85	98	5	MP:0012031
Domain	G_PROTEIN_RECEP_F1_1	VN1R3 GPR6 CYSLTR2 OR2A7 OR4K17 OR1B1 OR4C11 OR2G3 OR2AG2 OR2A5 OPN1SW MRGPRX1 GPR149 OR2A4 HRH2 MRGPRX4 PTGDR2	5.51e-06	685	130	17	PS00237
Domain	G_PROTEIN_RECEP_F1_2	VN1R3 GPR6 CYSLTR2 OR2A7 OR4K17 OR1B1 OR4C11 OR2G3 OR2AG2 OR2A5 OPN1SW MRGPRX1 GPR149 OR2A4 HRH2 MRGPRX4 PTGDR2	6.18e-06	691	130	17	PS50262
Domain	GPCR_Rhodpsn	VN1R3 GPR6 CYSLTR2 OR2A7 OR4K17 OR1B1 OR4C11 OR2G3 OR2AG2 OR2A5 OPN1SW MRGPRX1 GPR149 OR2A4 HRH2 MRGPRX4 PTGDR2	6.30e-06	692	130	17	IPR000276
Domain	WD40	WDR64 MED16 WDR18 EML2 TEP1 WDR37 WDFY4 WDR38 EML1 PLRG1	1.37e-05	259	130	10	PF00400
Domain	GPCR_Rhodpsn_7TM	GPR6 CYSLTR2 OR2A7 OR4K17 OR1B1 OR4C11 OR2G3 OR2AG2 OR2A5 OPN1SW MRGPRX1 GPR149 OR2A4 HRH2 MRGPRX4 PTGDR2	1.71e-05	670	130	16	IPR017452
Domain	WD40	WDR64 MED16 WDR18 EML2 TEP1 WDR37 WDFY4 WDR38 EML1 PLRG1	1.84e-05	268	130	10	SM00320
Domain	7tm_1	GPR6 CYSLTR2 OR2A7 OR4K17 OR1B1 OR4C11 OR2G3 OR2AG2 OR2A5 OPN1SW MRGPRX1 GPR149 OR2A4 HRH2 MRGPRX4 PTGDR2	1.94e-05	677	130	16	PF00001
Domain	WD40_repeat	WDR64 MED16 WDR18 EML2 TEP1 WDR37 WDFY4 WDR38 EML1 PLRG1	2.09e-05	272	130	10	IPR001680
Domain	WD_REPEATS_1	WDR64 MED16 WDR18 EML2 TEP1 WDR37 WDFY4 WDR38 EML1 PLRG1	2.52e-05	278	130	10	PS00678
Domain	ARM-type_fold	ARMC12 HEATR5A WDFY4 FOCAD URB1 IFRD1 XPO6 IQCB1 LTN1 CTNND1 HEATR5B	2.55e-05	339	130	11	IPR016024
Domain	WD_REPEATS_2	WDR64 MED16 WDR18 EML2 TEP1 WDR37 WDFY4 WDR38 EML1 PLRG1	2.60e-05	279	130	10	PS50082
Domain	WD_REPEATS_REGION	WDR64 MED16 WDR18 EML2 TEP1 WDR37 WDFY4 WDR38 EML1 PLRG1	2.60e-05	279	130	10	PS50294
Domain	WD40_repeat_dom	WDR64 MED16 WDR18 EML2 TEP1 WDR37 WDFY4 WDR38 EML1 PLRG1	4.41e-05	297	130	10	IPR017986
Domain	LRDF	LEFTY2 LEFTY1	4.81e-05	2	130	2	IPR003942
Domain	-	WDR64 MED16 WDR18 EML2 TEP1 WDR37 WDFY4 WDR38 EML1 PLRG1	1.14e-04	333	130	10	2.130.10.10
Domain	ARM-like	ARMC12 HEATR5A WDFY4 IFRD1 XPO6 IQCB1 LTN1 CTNND1 HEATR5B	1.16e-04	270	130	9	IPR011989
Domain	WD40/YVTN_repeat-like_dom	WDR64 MED16 WDR18 EML2 TEP1 WDR37 WDFY4 WDR38 EML1 PLRG1	1.20e-04	335	130	10	IPR015943
Domain	CONNEXINS_1	GJC1 GJB2 GJA10	2.94e-04	19	130	3	PS00407
Domain	CONNEXINS_2	GJC1 GJB2 GJA10	3.44e-04	20	130	3	PS00408
Domain	Connexin	GJC1 GJB2 GJA10	3.44e-04	20	130	3	IPR000500
Domain	Connexin_CCC	GJC1 GJB2 GJA10	3.44e-04	20	130	3	IPR019570
Domain	Connexin_N	GJC1 GJB2 GJA10	3.44e-04	20	130	3	IPR013092
Domain	Connexin	GJC1 GJB2 GJA10	3.44e-04	20	130	3	PF00029
Domain	Connexin_CCC	GJC1 GJB2 GJA10	3.44e-04	20	130	3	SM01089
Domain	Connexin_CS	GJC1 GJB2 GJA10	3.44e-04	20	130	3	IPR017990
Domain	CNX	GJC1 GJB2 GJA10	3.44e-04	20	130	3	SM00037
Domain	Anaphylatoxin_comp_syst	C4A C4B	4.74e-04	5	130	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	4.74e-04	5	130	2	IPR001840
Domain	zf-DHHC	ZDHHC16 ZDHHC12 ZDHHC23	5.27e-04	23	130	3	PF01529
Domain	DHHC	ZDHHC16 ZDHHC12 ZDHHC23	6.78e-04	25	130	3	PS50216
Domain	Znf_DHHC_palmitoyltrfase	ZDHHC16 ZDHHC12 ZDHHC23	6.78e-04	25	130	3	IPR001594
Domain	HELP	EML2 EML1	7.08e-04	6	130	2	PF03451
Domain	HELP	EML2 EML1	7.08e-04	6	130	2	IPR005108
Domain	-	ARMC12 HEATR5A WDFY4 IFRD1 XPO6 CTNND1 HEATR5B	9.36e-04	222	130	7	1.25.10.10
Domain	ANATO	C4A C4B	9.87e-04	7	130	2	SM00104
Domain	ANATO	C4A C4B	9.87e-04	7	130	2	PF01821
Domain	ANAPHYLATOXIN_2	C4A C4B	9.87e-04	7	130	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	9.87e-04	7	130	2	PS01177
Domain	Anaphylatoxin/fibulin	C4A C4B	9.87e-04	7	130	2	IPR000020
Domain	WD40_repeat_CS	WDR18 TEP1 WDR37 WDFY4 WDR38 PLRG1	1.02e-03	164	130	6	IPR019775
Domain	Thiol-ester_cl	C4A C4B	1.31e-03	8	130	2	PF10569
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	1.31e-03	8	130	2	IPR019565
Domain	MacrogloblnA2_CS	C4A C4B	1.31e-03	8	130	2	IPR019742
Domain	TGF-beta-rel	INHA LEFTY2 LEFTY1	1.41e-03	32	130	3	IPR015615
Domain	TGFb_CS	INHA LEFTY2 LEFTY1	1.41e-03	32	130	3	IPR017948
Domain	A2M_N	C4A C4B	2.09e-03	10	130	2	PF01835
Domain	A2M_N	C4A C4B	2.09e-03	10	130	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	2.09e-03	10	130	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	C4A C4B	2.09e-03	10	130	2	PS00477
Domain	A2M	C4A C4B	2.09e-03	10	130	2	PF00207
Domain	A2M_N_2	C4A C4B	2.09e-03	10	130	2	IPR011625
Domain	A2M_comp	C4A C4B	2.09e-03	10	130	2	IPR011626
Domain	A2M_N_2	C4A C4B	2.09e-03	10	130	2	PF07703
Domain	A2M_recep	C4A C4B	2.09e-03	10	130	2	PF07677
Domain	A2M_comp	C4A C4B	2.09e-03	10	130	2	PF07678
Domain	Macroglobln_a2	C4A C4B	2.09e-03	10	130	2	IPR001599
Domain	TGFB	INHA LEFTY2 LEFTY1	2.15e-03	37	130	3	SM00204
Domain	TGF-b_C	INHA LEFTY2 LEFTY1	2.15e-03	37	130	3	IPR001839
Domain	TGF_BETA_2	INHA LEFTY2 LEFTY1	2.15e-03	37	130	3	PS51362
Domain	TGF_beta	INHA LEFTY2 LEFTY1	2.15e-03	37	130	3	PF00019
Domain	TGF_BETA_1	INHA LEFTY2 LEFTY1	2.15e-03	37	130	3	PS00250
Domain	MRGPCRFAMILY	MRGPRX1 MRGPRX4	2.54e-03	11	130	2	IPR026234
Domain	G-protein_beta_WD-40_rep	WDR18 WDR37 WDR38 PLRG1	2.94e-03	85	130	4	IPR020472
Domain	Quinoprot_gluc/sorb_DH	MED16 EML2	3.03e-03	12	130	2	IPR011041
Domain	C345C	C4A C4B	6.11e-03	17	130	2	SM00643
Domain	Olfact_rcpt	OR2A7 OR4K17 OR1B1 OR4C11 OR2G3 OR2AG2 OR2A5 OR2A4	6.28e-03	393	130	8	IPR000725
Domain	Terpenoid_cyclase/PrenylTrfase	C4A C4B	6.84e-03	18	130	2	IPR008930
Pathway	WP_GPCRS_ODORANT	OR2A7 OPN1SW MRGPRX1 GPR149 OR2A4 OR1E3 MRGPRX4 PTGDR2	1.24e-05	157	97	8	MM15872
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	TOR1AIP2 ATP7A MBOAT7 VPS13C GGCX UBXN4 TRAPPC12 PARP16 STEAP3 CTNND1 DCTN4 HEATR5B	8.14e-07	504	137	12	34432599
Pubmed	Molecular genetics of the human MHC complement gene cluster.	DXO C4A C4B	3.30e-06	8	137	3	10072631
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	TOR1AIP2 GALNT10 ADGRG1 C11orf24 FOCAD TBC1D8 MED24 TMUB1 ORAI1 MDN1 MSMO1 ODR4 LTN1 STEAP3 C1orf159 FGFR1	4.72e-06	1061	137	16	33845483
Pubmed	Organizations and gene duplications of the human and mouse MHC complement gene clusters.	DXO C4A C4B	9.64e-06	11	137	3	10686478
Pubmed	Loss of late primitive streak mesoderm and interruption of left-right morphogenesis in the Ednrb(s-1Acrg) mutant mouse.	LEFTY2 LEFTY1 FGFR1	1.28e-05	12	137	3	10964471
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	1.54e-05	2	137	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	1.54e-05	2	137	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	1.54e-05	2	137	2	15998580
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	1.54e-05	2	137	2	19062096
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	1.54e-05	2	137	2	19933335
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	1.54e-05	2	137	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	1.54e-05	2	137	2	17645767
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	1.54e-05	2	137	2	12207352
Pubmed	LEFTY2 alleviates hepatic stellate cell activation and liver fibrosis by regulating the TGF-β1/Smad3 pathway.	LEFTY2 LEFTY1	1.54e-05	2	137	2	32745796
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	1.54e-05	2	137	2	27758680
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	1.54e-05	2	137	2	22387014
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	1.54e-05	2	137	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	1.54e-05	2	137	2	23918728
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	1.54e-05	2	137	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	1.54e-05	2	137	2	11726230
Pubmed	Fast-evolving cofactors regulate the role of HEATR5 complexes in intra-Golgi trafficking.	HEATR5A HEATR5B	1.54e-05	2	137	2	38240799
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	1.54e-05	2	137	2	4216347
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	1.54e-05	2	137	2	6950384
Pubmed	MUC4 potentiates invasion and metastasis of pancreatic cancer cells through stabilization of fibroblast growth factor receptor 1.	FGFR1 MUC4	1.54e-05	2	137	2	22791819
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	1.54e-05	2	137	2	8660986
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	1.54e-05	2	137	2	8428773
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	1.54e-05	2	137	2	24638111
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	1.54e-05	2	137	2	21345967
Pubmed	LEFTY, a member of the transforming growth factor-beta superfamily, inhibits uterine stromal cell differentiation: a novel autocrine role.	LEFTY2 LEFTY1	1.54e-05	2	137	2	20056823
Pubmed	Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development.	LEFTY2 LEFTY1	1.54e-05	2	137	2	10053005
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	1.54e-05	2	137	2	2572548
Pubmed	The complement component C4 of mammals.	C4A C4B	1.54e-05	2	137	2	2302180
Pubmed	Mutation analysis of human LEFTY A and LEFTY B genes in children with Ivemark syndrome.	LEFTY2 LEFTY1	1.54e-05	2	137	2	11100524
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	1.54e-05	2	137	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	1.54e-05	2	137	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	1.54e-05	2	137	2	29080553
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	1.54e-05	2	137	2	6589636
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	1.54e-05	2	137	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	1.54e-05	2	137	2	17728371
Pubmed	Structure and organization of the C4 genes.	C4A C4B	1.54e-05	2	137	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	1.54e-05	2	137	2	6149581
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	1.54e-05	2	137	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	1.54e-05	2	137	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	1.54e-05	2	137	2	2387317
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	1.54e-05	2	137	2	16908004
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	1.54e-05	2	137	2	7365238
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	1.54e-05	2	137	2	7391573
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	1.54e-05	2	137	2	17971360
Pubmed	Lefty1 and lefty2 control the balance between self-renewal and pluripotent differentiation of mouse embryonic stem cells.	LEFTY2 LEFTY1	1.54e-05	2	137	2	24147624
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	1.54e-05	2	137	2	29928053
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	1.54e-05	2	137	2	17971229
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	1.54e-05	2	137	2	6881182
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	1.54e-05	2	137	2	17921792
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	1.54e-05	2	137	2	21880985
Pubmed	Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.	C4A C4B	1.54e-05	2	137	2	6978711
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	1.54e-05	2	137	2	35898513
Pubmed	Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.	C4A C4B	1.54e-05	2	137	2	28873507
Pubmed	Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.	C4A C4B	1.54e-05	2	137	2	276882
Pubmed	Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.	C4A C4B	1.54e-05	2	137	2	6832377
Pubmed	Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.	C4A C4B	1.54e-05	2	137	2	3794341
Pubmed	Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes.	C4A C4B	1.54e-05	2	137	2	22785613
Pubmed	Association between complement 4 copy number variation and systemic lupus erythematosus: a meta-analysis.	C4A C4B	1.54e-05	2	137	2	32691186
Pubmed	Sequence and expression patterns of a human EMAP-related protein-2 (HuEMAP-2).	EML2 EML1	1.54e-05	2	137	2	10521658
Pubmed	The androgen-dependent C4-Slp gene is driven by a constitutively competent promoter.	C4A C4B	1.54e-05	2	137	2	8390682
Pubmed	Structure and expression of murine fourth complement component (C4) and sex-limited protein (Slp).	C4A C4B	1.54e-05	2	137	2	3902619
Pubmed	Leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) is a modulator of FGFR1.	LRIT3 FGFR1	1.54e-05	2	137	2	22673519
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	1.54e-05	2	137	2	7373044
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	1.54e-05	2	137	2	3696167
Pubmed	Lefty antagonises TGF-beta1 induced epithelial-mesenchymal transition in tubular epithelial cells.	LEFTY2 LEFTY1	1.54e-05	2	137	2	20171171
Pubmed	Stra3/lefty, a retinoic acid-inducible novel member of the transforming growth factor-beta superfamily.	LEFTY2 LEFTY1	1.54e-05	2	137	2	9496783
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	1.54e-05	2	137	2	1357031
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	1.54e-05	2	137	2	16098595
Pubmed	A functional role of LEFTY during progesterone therapy for endometrial carcinoma.	LEFTY2 LEFTY1	1.54e-05	2	137	2	29268772
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	1.54e-05	2	137	2	15787745
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	1.54e-05	2	137	2	30026462
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	1.54e-05	2	137	2	6559257
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	1.54e-05	2	137	2	34299197
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	1.54e-05	2	137	2	20506482
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	1.54e-05	2	137	2	12480675
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	1.54e-05	2	137	2	26800705
Pubmed	Murine complement C4 is not required for experimental autoimmune encephalomyelitis.	C4A C4B	1.54e-05	2	137	2	15390104
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	1.54e-05	2	137	2	1699796
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	1.54e-05	2	137	2	2997024
Pubmed	MUC4 expression is regulated by cystic fibrosis transmembrane conductance regulator in pancreatic adenocarcinoma cells via transcriptional and post-translational mechanisms.	CFTR MUC4	1.54e-05	2	137	2	16799633
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	1.54e-05	2	137	2	3624865
Pubmed	Lefty1 Ameliorates Post-infarction Fibrosis by Suppressing p-Smad2 and p-ERK1/2 Signaling Pathways.	LEFTY2 LEFTY1	1.54e-05	2	137	2	33409963
Pubmed	Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.	C4A C4B	1.54e-05	2	137	2	21857912
Pubmed	LEFTY2 inhibits endometrial receptivity by downregulating Orai1 expression and store-operated Ca2+ entry.	LEFTY2 LEFTY1	1.54e-05	2	137	2	29230527
Pubmed	Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.	C4A C4B	1.54e-05	2	137	2	6208559
Pubmed	The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.	C4A C4B	1.54e-05	2	137	2	4514997
Pubmed	The inheritance of susceptibility to the Gross leukemia virus in mice.	C4A C4B	1.54e-05	2	137	2	5919331
Pubmed	An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.	C4A C4B	1.54e-05	2	137	2	3167981
Pubmed	The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.	C4A C4B	1.54e-05	2	137	2	7545960
Pubmed	Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.	C4A C4B	1.54e-05	2	137	2	30041577
Pubmed	Complete cDNA sequence of the fourth component of murine complement.	C4A C4B	1.54e-05	2	137	2	3862104
Pubmed	The BS variant of C4 protects against age-related loss of white matter microstructural integrity.	C4A C4B	1.54e-05	2	137	2	34358307
Pubmed	Molecular analysis of LEFTY-expressing cells in early human embryoid bodies.	LEFTY2 LEFTY1	1.54e-05	2	137	2	17038673
Pubmed	Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.	C4A C4B	1.54e-05	2	137	2	18360261
Pubmed	Schizophrenia risk from complex variation of complement component 4.	C4A C4B	1.54e-05	2	137	2	26814963
Pubmed	Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.	C4A C4B	1.54e-05	2	137	2	8132550
Interaction	GPR17 interactions	ERAP1 GJC1 HEATR5A URB1 IFRD1 MDN1 SACS XPO6 LTN1 HEATR5B DOP1A LRRC41	1.83e-07	283	124	12	int:GPR17
Interaction	TACSTD2 interactions	MED16 TBC1D8 MED24 URB1 MDN1 SACS XPO6 DOP1A	1.34e-06	129	124	8	int:TACSTD2
Interaction	HCST interactions	CDS1 ATP7A TTC28 EARS2 GGCX FOCAD MDN1 XPO6 LTN1	5.06e-06	205	124	9	int:HCST
Interaction	APLNR interactions	TOR1AIP2 MBOAT7 ERAP1 XRCC3 GGCX GJB2 MDN1 MSMO1 PEX16	6.39e-06	211	124	9	int:APLNR
Interaction	GPR182 interactions	CDS1 EARS2 ERAP1 ADGRG1 GGCX FOCAD URB1 GTF2H4 MDN1 MSMO1 XPO6 LTN1	2.46e-05	455	124	12	int:GPR182
Interaction	SCN2B interactions	CDS1 CFTR FOCAD MDN1 XPO6 C4A	2.67e-05	95	124	6	int:SCN2B
Interaction	TMEM89 interactions	TMEM89 C4A	3.76e-05	2	124	2	int:TMEM89
Interaction	LAMP3 interactions	TOR1AIP2 ATP7A TTC28 MBOAT7 VPS13C XRCC3 TBC1D8 UBXN4 MDN1 LTN1 STEAP3 CTNND1	4.67e-05	486	124	12	int:LAMP3
Interaction	CACNG6 interactions	CDS1 MSMO1 XPO6 PIGW	5.49e-05	34	124	4	int:CACNG6
Interaction	NPTN interactions	TTC28 EARS2 XRCC3 FOCAD MDN1 XPO6 LTN1 HEATR5B DOP1A	5.65e-05	278	124	9	int:NPTN
Cytoband	6p21.3	DXO SYNGAP1 GTF2H4 C4A C4B RGL2	1.11e-04	250	137	6	6p21.3
Cytoband	1q42.1	LEFTY2 LEFTY1	5.72e-04	12	137	2	1q42.1
Cytoband	Ensembl 112 genes in cytogenetic band chr6p21	DXO ARMC12 SYNGAP1 GTF2H4 C4A C4B RGL2	8.23e-04	503	137	7	chr6p21
Cytoband	2q21.3	UBXN4 MGAT5	9.05e-04	15	137	2	2q21.3
GeneFamily	WD repeat domain containing	WDR64 MED16 WDR18 EML2 TEP1 WDR37 WDFY4 WDR38 EML1 PLRG1	1.89e-06	262	100	10	362
GeneFamily	Gap junction proteins	GJC1 GJB2 GJA10	2.34e-04	22	100	3	314
GeneFamily	Zinc fingers DHHC-type\|Ankyrin repeat domain containing	ZDHHC16 ZDHHC12 ZDHHC23	3.05e-04	24	100	3	76
GeneFamily	Olfactory receptors, family 2	OR2A7 OR2G3 OR2AG2 OR2A5 OR2A4	4.10e-04	113	100	5	149
GeneFamily	SUMO specific peptidases\|5FMC ribosome biogenesis complex	WDR18 LAS1L	4.48e-04	6	100	2	1301
GeneFamily	G protein-coupled receptors, Class A orphans	GPR6 MRGPRX1 GPR149 MRGPRX4	9.19e-04	78	100	4	262
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	1.06e-03	9	100	2	1234
ToppCell	LPS_only-Epithelial_alveolar-AT_2-AT2_Progenitor\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CDS1 ARHGEF28 ANK3 CFTR TSPEAR GPC6 MSMO1	1.30e-06	181	134	7	0513b9e6673ff7bf8e72ba123ca3794b65d10170
ToppCell	droplet-Lung-LUNG-1m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDS1 TEP1 WDFY4 ORAI1 CCDC88A FGFR1	1.12e-05	166	134	6	c215c4aede38d355d35fd26cd7ef2c19efecd0e6
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDS1 TEP1 WDFY4 ORAI1 CCDC88A FGFR1	1.24e-05	169	134	6	735655e75511c5c41aca667909e8bb52a0ad7fc6
ToppCell	facs-Marrow-T-cells-3m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDS1 ATP7A VPS13C CCDC88A GJA10 RSPO1	1.28e-05	170	134	6	a78d9789c3e7c84a36e1bd380192d7aba4a4d443
ToppCell	facs-Marrow-T-cells-3m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDS1 ATP7A VPS13C CCDC88A GJA10 RSPO1	1.28e-05	170	134	6	ff68600b945b3a5437b14e5411b3db800d0ccbe5
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-AT2_Progenitor\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CDS1 ANK3 CFTR TSPEAR GPC6 MSMO1	1.72e-05	179	134	6	7db6b97a1c4c7a163d5da4351ba36ac1785d9d7b
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CDS1 ARHGEF28 ANK3 CFTR GPC6 MSMO1	1.77e-05	180	134	6	b798a3fa2dd15b68aa4267f665559527043dcc07
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CDS1 ARHGEF28 ANK3 CFTR TSPEAR GPC6	2.01e-05	184	134	6	ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCell	Control-Epithelial_alveolar-AT_2-Differentiating_AT2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CDS1 ARHGEF28 ANK3 CFTR TSPEAR GPC6	2.07e-05	185	134	6	0d2add28ac1f4fa6de7699be009bf8391badaf4c
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CDS1 ARHGEF28 ANK3 CFTR TSPEAR GPC6	2.26e-05	188	134	6	4bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCell	Severe-B_intermediate-10\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	GALNTL6 ANK3 VPS13C CHD3 WDFY4 TBC1D8	3.03e-05	198	134	6	dfae26c3513a82bb7cb8dadbfcea2a1f420b1bab
Disease	Charlevoix-Saguenay spastic ataxia (implicated_via_orthology)	ANKFY1 SACS	1.81e-05	2	126	2	DOID:0050946 (implicated_via_orthology)
Disease	pulse pressure measurement, anxiety	CHD3 GJA10	3.75e-04	7	126	2	EFO_0005230, EFO_0005763
Disease	glucose metabolism decline measurement, cingulate cortex measurement	CDH23 TBC1D8	6.39e-04	9	126	2	EFO_0007738, EFO_0009392
Disease	Pulmonary Cystic Fibrosis	CFTR DCTN4	6.39e-04	9	126	2	C0392164
Disease	Fibrocystic Disease of Pancreas	CFTR DCTN4	6.39e-04	9	126	2	C1527396
Disease	Cleft palate, tobacco smoke exposure measurement, cleft lip, parental genotype effect measurement	ANK3 FOCAD	9.70e-04	11	126	2	EFO_0003959, EFO_0005939, EFO_0009115, HP_0000175
Disease	Cystic Fibrosis	CFTR DCTN4	9.70e-04	11	126	2	C0010674
Disease	Myeloproliferative disease	MPL FGFR1	1.16e-03	12	126	2	C0027022
Disease	Ciliopathies	CFTR CDH23 LEFTY2 IQCB1	1.29e-03	110	126	4	C4277690
Disease	Autosomal Dominant Myotubular Myopathy	SELENON ORAI1	1.37e-03	13	126	2	C3661489
Disease	Centronuclear myopathy	SELENON ORAI1	1.37e-03	13	126	2	C0175709
Disease	X-linked centronuclear myopathy	SELENON ORAI1	1.37e-03	13	126	2	C0410203
Disease	DEAFNESS, AUTOSOMAL RECESSIVE (disorder)	CDH23 GJB2	1.37e-03	13	126	2	C1846647
Disease	Myopathy, Centronuclear, 1	SELENON ORAI1	1.37e-03	13	126	2	C4551952
Disease	Asthma, Aspirin-Induced	CYSLTR2 PTGDR2	1.37e-03	13	126	2	C1319853
Disease	Congenital Structural Myopathy	SELENON ORAI1	1.37e-03	13	126	2	C0752282
Disease	complement C4 measurement	DXO GTF2H4 C4B	1.44e-03	52	126	3	EFO_0004984
Disease	Myopathy, Centronuclear, Autosomal Dominant	SELENON ORAI1	1.59e-03	14	126	2	C1834558
Disease	Tubular Aggregate Myopathy	SELENON ORAI1	1.59e-03	14	126	2	C0410207
Disease	Autosomal Recessive Centronuclear Myopathy	SELENON ORAI1	1.83e-03	15	126	2	C3645536
Disease	Keratoderma, Palmoplantar	GJB2 RSPO1	2.09e-03	16	126	2	C4551675
Disease	PROSTATE CANCER, HEREDITARY, 1	TTC28 ADGRG1 CHD3	2.18e-03	60	126	3	C4722327
Disease	Antibody Deficiency Syndrome	EPG5 C4A	2.36e-03	17	126	2	C0003257
Disease	Congenital Fiber Type Disproportion	SELENON ORAI1	2.65e-03	18	126	2	C0546264
Disease	age-related hearing impairment	GALNTL6 GPR6 ARHGEF28 TTC28 CDH23 GJB2	2.74e-03	324	126	6	EFO_0005782
Disease	Prostate cancer, familial	TTC28 ADGRG1 CHD3	3.24e-03	69	126	3	C2931456

Protein segments in the cluster

Peptide	Gene	Start	Entry
LRVELTHGAETLTLW	MAMDC4	156	Q6UXC1
VISSSALSLHDWIAS	ERVPABLB-1	426	P60509
TRLLESIHLALTAWG	EPG5	1786	Q9HCE0
WTHVTLLITVTQSHL	CDS1	216	Q92903
IFTHLVTSLKGLWTL	CFTR	1051	P13569
DSLTTWEIHGLSLSK	C4B	801	P0C0L5
TTETGWLCLHSVALI	ABCD2	101	Q9UBJ2
SHSTIVGKIWLTILF	GJA10	16	Q969M2
SVTLLWSILHQADSS	DOP1A	1771	Q5JWR5
TTWCSVALALLVALH	EDN2	6	P20800
VITLSWLQHLSGKVV	ASB14	481	A6NK59
HSTSIGKIWLTVLFI	GJB2	16	P29033
ATSCHVAWLLVLISG	CDH23	6	Q9H251
ELISTIWDTELHIAG	ARMC12	156	Q5T9G4
LTLPWDHIQSTLLKT	ATP7A	96	Q04656
GITHIDTLNRWSELT	KIAA1107	1231	Q9UPP5
SREHGTLWSLIIAKL	LTN1	1081	O94822
THLELPLEWTVLGSS	ARHGEF28	141	Q8N1W1
GSTALWLAVQHITVS	ANKFY1	401	Q9P2R3
WVTIRLLETIDVHSG	MSMO1	216	Q15800
GWATVSVIALSNILH	MUC4	4806	Q99102
TLVLLISWDSRLHSP	OR1B1	46	Q8NGR6
ATSWILASLIAIGHT	OR2AG2	146	A6NM03
GISSRHLTAITVDVW	KIAA0100	211	Q14667
LSSSHVTLGEWVERT	MDN1	3091	Q9NU22
TLLGVHLLLAATWTV	GPR6	181	P46095
HLLLAATWTVSLGLG	GPR6	186	P46095
SLIDSRLVSVHESGW	LEFTY1	161	O75610
WSDLITSLYLLGHDI	MGAT5	301	Q09328
TLDAVLVSHAVTTLW	MSS51	201	Q4VC12
EGWSSLLRTVHSVLN	GALNT10	156	Q86SR1
HESLSIENTLWASTI	ATP9B	326	O43861
ATSVLAGLTAHLWDL	C20orf203	46	Q8NBC4
HIELAWAFSTVIGTL	ORAI1	171	Q96D31
SLHLGWELEQISRTS	CCDC88A	426	Q3V6T2
LIHANLTTLTFWGTT	ERAP1	66	Q9NZ08
ITGSHDTTIRLWDLV	PLRG1	346	O43660
LLVVTSWLLGLLHSG	OR4K17	146	Q8NGC6
GLSSSWLSLECTVHI	ODR4	171	Q5SWX8
LIWVISITLSFLSIH	HRH2	141	P25021
LHSLVTILGTWALIQ	MBOAT7	51	Q96N66
LSAHGIVVAWLSRAE	LAS1L	36	Q9Y4W2
WTHLVSTPSGVLDLS	LRIT3	176	Q3SXY7
TSWTTGVLLSLIHLV	OR2A7	146	Q96R45
ILIVLAWIGSLIHST	OR4C11	141	Q6IEV9
AWIGSLIHSTAQIIL	OR4C11	146	Q6IEV9
VTTWVLHLALSDLLA	PTGDR2	66	Q9Y5Y4
EAIVTWRGHLTKLLT	DXO	126	O77932
LHLVWTLRDVSEGSV	PAX2	221	Q02962
LSWTSLALVGIDSHG	MED16	436	Q9Y2X0
TSWTTGVLLSLIHLV	OR2A4	146	O95047
VTSWACGSLLALVHV	OR2A5	146	Q96R48
VSWILSSKVLTIHSA	PARP16	86	Q8N5Y8
LGVVLTVWAASLLLS	GPR149	151	Q86SP6
IRALLSTLHTVLWDG	GAK	1231	O14976
TWALHSLSLIIDSAG	HEATR5A	951	Q86XA9
ALILHATALWLTSTG	HEATR5A	1496	Q86XA9
VQTWSLHSLALIVDS	HEATR5B	951	Q9P2D3
HSLLSWSLTCIVLAL	GPC6	536	Q9Y625
SIGLSHHSAWLTVLE	FGFR1	346	P11362
ATLLLTWGLEDVEHV	CHD3	136	Q12873
HSTFVGKIWLTVLIV	GJC1	16	P36383
ALLGDRWILTAAHTI	C1RL	271	Q9NZP8
WSHVLTLLGLSLVLG	ADGRG1	606	Q9Y653
IVADHLGLSWTELAR	ANK3	4096	Q12955
SLIDSRLVSVHESGW	LEFTY2	161	O00292
PNTVLHISSLLAWTL	IFRD1	236	O00458
HISSLLAWTLLLTIC	IFRD1	241	O00458
WAVLHLATSALSLLT	INHA	176	P05111
TDSLFWLLGGHVELI	IQCB1	146	Q15051
LIQWLHTTLVETLSL	KANSL3	191	Q9P2N6
RIWDSVTLNTLHVIG	EML1	306	O00423
IWDSVSLSTLHVLGL	EML2	141	O95834
GTVTGRWLLLDTETH	EML2	436	O95834
LSSLPVVREWALTHT	C1orf159	46	Q96HA4
GTEVIWLTQHVELSL	DCTN4	441	Q9UJW0
LSLSSVLSHVSGLGW	DHRS1	276	Q96LJ7
IDGSDLHSAVIITWI	SACS	3001	Q9NZJ4
HGVGLLATDLLSTWS	PRRT3	581	Q5FWE3
VITGTLWNLSSHDSI	CTNND1	471	O60716
DSLTTWEIHGLSLSK	C4A	801	P0C0L4
VWLLGHLHLSTLSSS	FOCAD	1331	Q5VW36
CLGLLTLSWLLTTAH	OR1E3	141	Q8WZA6
TLSWLLTTAHATLHT	OR1E3	146	Q8WZA6
SISWLSGLASSLIHA	OR2G3	146	Q8NGZ4
SSKHALTVVLATWTI	OPN1SW	146	P03999
VHLAWDLSRSLGAVV	OIP5	91	O43482
WLLAGVVDVTSLSLL	PEX16	246	Q9Y5Y5
EGWTSLLRTIHSIIN	GALNTL6	151	Q49A17
TEVAISVLSTWLASH	RGL2	156	O15211
DKLSGLWSRISHLVL	TOR1AIP2	441	Q8NFQ8
SHRLLSTEWGLPSIV	PRELID3B	51	Q9Y3B1
AALTLCHLLSSWVSL	LRRC41	476	Q15345
CHLLSSWVSLESLTL	LRRC41	481	Q15345
ASSWTAIEHSLLKLG	MED24	186	O75448
VLSWTHLTISSRGIK	RSPO1	11	Q2MKA7
HSTVINLLTWIVLLS	PGAP1	816	Q75T13
LAGVAESIHLWEVST	WDR18	96	Q9BV38
ESIHLWEVSTGNLLV	WDR18	101	Q9BV38
WEVSTGNLLVILSRH	WDR18	106	Q9BV38
EAISNTTWDLISLHS	IMPG2	316	Q9BZV3
THLSAVVCVLLWALS	MRGPRX1	136	Q96LB2
VDSWSLGVLLYILVH	NUAK2	231	Q9H093
SLSHWALVSVLSLLA	SLC38A8	246	A6NNN8
THLSAVVCVLLWGLS	MRGPRX4	136	Q96LA9
LLSNVISLLHTLWVT	URB1	1871	O60287
ISLLHTLWVTNLGDK	URB1	1876	O60287
ISHVLRGSEWLVSTA	EARS2	241	Q5JPH6
RGSEWLVSTAKHLLL	EARS2	246	Q5JPH6
VDTLHSSTLWALFVV	PIGW	466	Q7Z7B1
ILGATTLSVSILLWA	ATRAID	206	Q6UW56
LLHVTSIRSAWILCG	CYSLTR2	146	Q9NS75
VLIWIFSLSLSESHA	C11orf24	6	Q96F05
STGLLSGLRIWHTQL	GTF2H4	86	Q92759
HLLLWVESLDSLLGV	TMEM64	146	Q6YI46
IHLEVHWSLITVTLS	SENP5	641	Q96HI0
SEELTSLLVVHWGGL	GGCX	246	P38435
LTVDQLHGVLSVWRT	TEP1	1426	Q99973
VLLAVALWTGGTIHS	OR4E1	146	P0C645
LITWLEGHSLAQTVF	NAA35	116	Q5VZE5
VALVLSTLHTLTYGW	STEAP3	401	Q658P3
GRELSTLHALLWEVL	SYNGAP1	686	Q96PV0
LWISVLTSLLEAFAH	APCS	6	P02743
LLTSHTTDSLQLWFV	TRAPPC12	416	Q8WVT3
WTVSLEHILASLLTE	TBC1D8	1081	O95759
LVHSILLWGALDDQS	SELENON	446	Q9NZV5
HLEELLGLVVWLTTC	WDFY4	336	Q6ZS81
TLGELSLLTANEHWT	VPS13C	221	Q709C8
ATETAWISLVTALHL	MPL	486	P40238
WISLVTALHLVLGLS	MPL	491	P40238
EGLLFTWLLVLVSSH	PIGZ	181	Q86VD9
SWHLSLDTAIRVALA	PILRB	181	Q9UKJ0
SVALALGALTVWHAV	ZDHHC16	276	Q969W1
ASWHFLLGVVVLTSL	ZDHHC23	106	Q8IYP9
VLGTASADHTALLWS	WDR37	171	Q9Y2I8
ATHISWKLSALVLTP	TTC28	1546	Q96AY4
TTSSLLIQLKGHVTW	WDR38	221	Q5JTN6
EVTLETWEHIVSLGL	ZNF544	41	Q6NX49
TWEHIVSLGLFLSKS	ZNF544	46	Q6NX49
LLLLVTSASTHAWSR	TMEM89	11	A2RUT3
VWSHEGLVLTKLLTS	TMEM219	181	Q86XT9
ALVDGRWHTLVLAVS	TSPEAR	151	Q8WU66
LLTGILETVWDKHSV	XPO6	186	Q96QU8
TWGITLVLFLHDTEL	ZDHHC12	21	Q96GR4
LLVLALAWVSTHTAE	TMUB1	21	Q9BVT8
TLVNITVLLHVTGKW	VN1R3	141	Q9BXE9
ASIVHSSSGDIWTLL	UBXN4	401	Q92575
SLLTLLWTHTLTVLV	UNC13D	816	Q70J99
LWTHTLTVLVEAAAS	UNC13D	821	Q70J99
LSSPEVWHLLRTASL	XRCC3	41	O43542
VVLTASIDGSVRLWH	WDR64	881	B1ANS9
WVAALQGLTEHTSIL	MYBPC3	916	Q14896
TLWLLVGLSVHVVAV	GRIN1	561	Q05586