Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	B4GALT2 B4GALT3	1.76e-05	5	27	2	GO:0003831
GeneOntologyMolecularFunction	N-acetyllactosamine synthase activity	B4GALT2 B4GALT3	1.76e-05	5	27	2	GO:0003945
GeneOntologyMolecularFunction	UDP-glycosyltransferase activity	B4GALT2 GALNTL6 GALNT10 B4GALT3	5.07e-05	153	27	4	GO:0008194
GeneOntologyMolecularFunction	hexosyltransferase activity	B4GALT2 GALNTL6 GALNT10 B4GALT3	1.76e-04	211	27	4	GO:0016758
GeneOntologyMolecularFunction	polypeptide N-acetylgalactosaminyltransferase activity	GALNTL6 GALNT10	3.30e-04	20	27	2	GO:0004653
GeneOntologyMolecularFunction	glycosyltransferase activity	B4GALT2 GALNTL6 GALNT10 B4GALT3	5.73e-04	288	27	4	GO:0016757
GeneOntologyMolecularFunction	carbohydrate binding	GALNTL6 GALNT10 MAN2C1 CLEC11A	7.54e-04	310	27	4	GO:0030246
GeneOntologyMolecularFunction	UDP-galactosyltransferase activity	B4GALT2 B4GALT3	8.52e-04	32	27	2	GO:0035250
GeneOntologyMolecularFunction	galactosyltransferase activity	B4GALT2 B4GALT3	1.02e-03	35	27	2	GO:0008378
GeneOntologyMolecularFunction	acetylgalactosaminyltransferase activity	GALNTL6 GALNT10	1.02e-03	35	27	2	GO:0008376
GeneOntologyMolecularFunction	calcium channel regulator activity	GRM2 REM2	2.41e-03	54	27	2	GO:0005246
GeneOntologyCellularComponent	Golgi membrane	B4GALT2 GALNTL6 PRKCE GALNT10 DBNL B4GALT3	2.62e-04	721	27	6	GO:0000139
Domain	SH3_9	SRMS ARHGEF6 SH3KBP1 DBNL	4.59e-06	78	27	4	PF14604
Domain	-	B4GALT2 GALNTL6 GALNT10 B4GALT3	5.34e-06	81	27	4	3.90.550.10
Domain	Nucleotide-diphossugar_trans	B4GALT2 GALNTL6 GALNT10 B4GALT3	7.43e-06	88	27	4	IPR029044
Domain	SH3	SRMS PLCG1 ARHGEF6 SH3KBP1 DBNL	1.30e-05	216	27	5	PS50002
Domain	SH3	SRMS PLCG1 ARHGEF6 SH3KBP1 DBNL	1.30e-05	216	27	5	SM00326
Domain	SH3_domain	SRMS PLCG1 ARHGEF6 SH3KBP1 DBNL	1.42e-05	220	27	5	IPR001452
Domain	Galactosyl_T	B4GALT2 B4GALT3	4.21e-05	7	27	2	IPR003859
Domain	Galactosyl_T_C	B4GALT2 B4GALT3	4.21e-05	7	27	2	IPR027791
Domain	Galactosyl_T_N	B4GALT2 B4GALT3	4.21e-05	7	27	2	IPR027995
Domain	Glyco_transf_7C	B4GALT2 B4GALT3	4.21e-05	7	27	2	PF02709
Domain	Glyco_transf_7N	B4GALT2 B4GALT3	4.21e-05	7	27	2	PF13733
Domain	SH3_1	PLCG1 ARHGEF6 SH3KBP1 DBNL	8.59e-05	164	27	4	PF00018
Domain	SH3_2	SRMS ARHGEF6 SH3KBP1	2.55e-04	86	27	3	IPR011511
Domain	SH3_2	SRMS ARHGEF6 SH3KBP1	2.55e-04	86	27	3	PF07653
Domain	Ricin_B_lectin	GALNTL6 GALNT10	5.92e-04	25	27	2	PF00652
Domain	RICIN	GALNTL6 GALNT10	7.43e-04	28	27	2	SM00458
Domain	RICIN_B_LECTIN	GALNTL6 GALNT10	7.43e-04	28	27	2	PS50231
Domain	Glyco_trans_2-like	GALNTL6 GALNT10	8.54e-04	30	27	2	IPR001173
Domain	Ricin_B_lectin	GALNTL6 GALNT10	8.54e-04	30	27	2	IPR000772
Domain	Glycos_transf_2	GALNTL6 GALNT10	8.54e-04	30	27	2	PF00535
Domain	SH2	SRMS PLCG1	9.31e-03	101	27	2	PF00017
Pathway	KEGG_MEDICUS_REFERENCE_BLOOD_GROUP_H_O_ANTIGEN_TYPE_2_BIOSYNTHESIS	B4GALT2 B4GALT3	5.32e-05	7	23	2	M47965
Pathway	PID_TCR_PATHWAY	PRKCE PLCG1 DBNL	1.48e-04	64	23	3	M34
Pathway	KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE	B4GALT2 B4GALT3	2.64e-04	15	23	2	M3042
Pathway	REACTOME_N_GLYCAN_ANTENNAE_ELONGATION	B4GALT2 B4GALT3	2.64e-04	15	23	2	M966
Pathway	REACTOME_N_GLYCAN_ANTENNAE_ELONGATION	B4GALT2 B4GALT3	2.64e-04	15	23	2	MM15700
Pathway	BIOCARTA_PTDINS_PATHWAY	PRKCE PLCG1	3.01e-04	16	23	2	MM1454
Pathway	KEGG_MEDICUS_REFERENCE_N_GLYCAN_BIOSYNTHESIS	B4GALT2 B4GALT3	3.01e-04	16	23	2	M47632
Pathway	BIOCARTA_PTDINS_PATHWAY	PRKCE PLCG1	6.31e-04	23	23	2	M8809
Pathway	KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES	B4GALT2 B4GALT3	8.08e-04	26	23	2	M17377
Pathway	REACTOME_SYNTHESIS_OF_IP3_AND_IP4_IN_THE_CYTOSOL	ITPKC PLCG1	8.08e-04	26	23	2	M27053
Pathway	REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI	B4GALT2 B4GALT3	8.08e-04	26	23	2	M979
Pathway	REACTOME_KERATAN_SULFATE_BIOSYNTHESIS	B4GALT2 B4GALT3	9.38e-04	28	23	2	M670
Pathway	REACTOME_SYNTHESIS_OF_IP3_AND_IP4_IN_THE_CYTOSOL	ITPKC PLCG1	9.38e-04	28	23	2	MM14711
Pathway	REACTOME_KERATAN_SULFATE_BIOSYNTHESIS	B4GALT2 B4GALT3	9.38e-04	28	23	2	MM14798
Pathway	REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI	B4GALT2 B4GALT3	1.01e-03	29	23	2	MM15699
Pathway	KEGG_O_GLYCAN_BIOSYNTHESIS	GALNTL6 GALNT10	1.08e-03	30	23	2	M6929
Pathway	PID_CDC42_REG_PATHWAY	PLCG1 ARHGEF6	1.08e-03	30	23	2	M83
Pathway	REACTOME_KERATAN_SULFATE_KERATIN_METABOLISM	B4GALT2 B4GALT3	1.55e-03	36	23	2	M690
Pathway	REACTOME_KERATAN_SULFATE_KERATIN_METABOLISM	B4GALT2 B4GALT3	1.55e-03	36	23	2	MM14632
Pubmed	Protein kinase Cepsilon may act as EGF-inducible scaffold protein for phospholipase Cgamma1.	PRKCE PLCG1	6.25e-07	2	28	2	17561374
Pubmed	A family of human beta4-galactosyltransferases. Cloning and expression of two novel UDP-galactose:beta-n-acetylglucosamine beta1, 4-galactosyltransferases, beta4Gal-T2 and beta4Gal-T3.	B4GALT2 B4GALT3	1.87e-06	3	28	2	9405390
Pubmed	Galactosylation of N-linked oligosaccharides by human beta-1,4-galactosyltransferases I, II, III, IV, V, and VI expressed in Sf-9 cells.	B4GALT2 B4GALT3	1.87e-06	3	28	2	11588157
Pubmed	Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport.	B4GALT2 MAN2C1 B4GALT3	3.56e-06	37	28	3	2542563
Pubmed	Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1.	B4GALT2 MAN2C1 B4GALT3	3.56e-06	37	28	3	2541446
Pubmed	Differential gene expression of beta-1,4-galactosyltransferases I, II and V during mouse brain development.	B4GALT2 B4GALT3	3.75e-06	4	28	2	11145975
Pubmed	Role of phospholipase Cgamma-induced activation of protein kinase Cepsilon (PKCepsilon) and PKCbetaI in epidermal growth factor-mediated protection of tight junctions from acetaldehyde in Caco-2 cell monolayers.	PRKCE PLCG1	3.75e-06	4	28	2	17991733
Pubmed	Requirement for phosphatidylinositol transfer protein in epidermal growth factor signaling.	PLCG1 PI4KA	3.75e-06	4	28	2	7761838
Pubmed	Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis.	B4GALT2 MAN2C1 B4GALT3	3.87e-06	38	28	3	2829950
Pubmed	Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1.	B4GALT2 MAN2C1 B4GALT3	3.87e-06	38	28	3	2187500
Pubmed	Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.	PLCG1 ARHGEF6 SH3KBP1 DBNL	3.90e-06	133	28	4	15144186
Pubmed	Abl-SH3 binding protein 2, 3BP2, interacts with CIN85 and HIP-55.	SH3KBP1 DBNL	6.24e-06	5	28	2	17306257
Pubmed	The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.	PLCG1 ARHGEF6 SH3KBP1	6.93e-06	46	28	3	23793062
Pubmed	Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein.	B4GALT2 MAN2C1 B4GALT3	6.93e-06	46	28	3	2649653
Pubmed	The expanding beta 4-galactosyltransferase gene family: messages from the databanks.	B4GALT2 B4GALT3	9.36e-06	6	28	2	9597550
Pubmed	Comparison of HPLC/ESI-FTICR MS versus MALDI-TOF/TOF MS for glycopeptide analysis of a highly glycosylated HIV envelope glycoprotein.	B4GALT2 B4GALT3	1.31e-05	7	28	2	18565761
Pubmed	The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner.	ARHGEF6 SH3KBP1	2.80e-05	10	28	2	17314030
Pubmed	EGF-stimulated signaling by means of PI3K, PLCgamma1, and PKC isozymes regulates branching morphogenesis of the fetal mouse submandibular gland.	PRKCE PLCG1	4.85e-05	13	28	2	12761849
Pubmed	Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.	B4GALT2 B4GALT3	7.45e-05	16	28	2	10580128
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	CEP170 PLCG1 SH3KBP1	1.23e-04	120	28	3	31413325
Pubmed	Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.	PRKCE PLCG1	1.71e-04	24	28	2	10843712
Pubmed	Mechanism of HIV-1-TAT induction of interleukin-1beta from human monocytes: Involvement of the phospholipase C/protein kinase C signaling cascade.	PRKCE PLCG1	2.17e-04	27	28	2	20336759
Pubmed	Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.	GRM2 REM2 PI4KA KCNJ9	2.97e-04	405	28	4	38187761
Pubmed	Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages.	ITPKC POLG	3.05e-04	32	28	2	26142281
Pubmed	Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.	PRKCE PLCG1	4.32e-04	38	28	2	12482669
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CEP170 FIP1L1 PRKCE PI4KA DBNL	5.63e-04	861	28	5	36931259
Pubmed	Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp).	KCNJ9 B4GALT3	7.18e-04	49	28	2	10051400
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	CEP170 FIP1L1 ARHGEF6 SH3KBP1 DBNL	7.44e-04	916	28	5	32203420
GeneFamily	Beta 4-glycosyltransferases	B4GALT2 B4GALT3	1.57e-04	17	20	2	425
GeneFamily	Polypeptide N-acetylgalactosaminyltransferases	GALNTL6 GALNT10	2.18e-04	20	20	2	433
GeneFamily	SH2 domain containing	SRMS PLCG1	5.50e-03	101	20	2	741
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLCG1 ARHGEF6	2.15e-02	206	20	2	682
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B4GALT2 ZSWIM9 GALNT10 CA8	4.02e-06	173	28	4	2b448acd5e584f24567204c31b8d74715e92f32a
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B4GALT2 ZSWIM9 GALNT10 CA8	4.02e-06	173	28	4	5086edc29c5a6137ca09877929a1317f9739c801
Drug	Bethanechol chloride [590-63-6]; Up 200; 20.4uM; HL60; HT_HG-U133A	B4GALT2 ITPKC GALNT10 PLCG1 VSIG10	3.67e-06	195	28	5	2975_UP
Drug	D-myo-inositol-1,4,5-triphosphate	SRMS PRKCE ITPKC PLCG1 GRM2 PI4KA CA8	4.35e-06	568	28	7	CID000000806
Disease	macrophage migration inhibitory factor measurement	GALNTL6 FIP1L1	6.59e-04	43	26	2	EFO_0008221
Disease	complement factor H-related protein 1 measurement	GALNTL6 PRKCE	1.12e-03	56	26	2	EFO_0600054

Protein segments in the cluster

Peptide	Gene	Start	Entry
LYGQPSWWGDDEVDE	CEP170	176	Q5SW79
FPNEYWGWGGEDDDI	B4GALT2	271	O60909
FPNEYWGWGGEDDDI	B4GALT3	251	O60512
IIYVTRVEEGGWWEG	ARHGEF6	186	Q15052
LPQEYIRWGDAWAVG	GRM2	556	Q14416
PWAEGNREDGYLWGL	ITPKC	656	Q96DU7
GAIWWLIAYGRGDLE	KCNJ9	76	Q92806
RKWFWELGGYDPGLE	GALNT10	326	Q86SR1
ELEYGPSVDWWALGV	PRKCE	581	Q02156
GPYQERIWVGGEGWG	C20orf203	91	Q8NBC4
EEEEWLYGGPWDVHV	FIP1L1	21	Q6UN15
WAEGWTRYGPEGEAV	POLG	171	P54098
GFAVEGSGLWPEEWY	PI4KA	806	P42356
GSGLWPEEWYEGVCE	PI4KA	811	P42356
GVEWGYEEGVEWGLV	CA8	26	P35219
WESDGEGLVWRDGEP	MAN2C1	101	Q9NTJ4
IEVIDEGWWRGYGPD	DBNL	401	Q9UJU6
RKWFWELGGYDPGLE	GALNTL6	321	Q49A17
WWEGELNGRRGVFPD	SH3KBP1	306	Q96B97
LGEGYFGEVWEGLWL	SRMS	236	Q9H3Y6
EREWEGGWGGAQEEE	CLEC11A	26	Q9Y240
GEKDWGLEGYVWRGS	ZSWIM9	566	Q86XI8
VEKQEGGWWRGDYGG	PLCG1	821	P19174
VVYDIWEQGDAGGWL	REM2	166	Q8IYK8
YWEVDVGDKPRWALG	TRIM72	346	Q6ZMU5
GFREGGEDDDWTLYW	TTLL6	81	Q8N841
EQEGYWLPGDEIDWE	ZMYND11	81	Q15326
RWDGGYPDPDFLWIE	VSIG10	246	Q8N0Z9
RIVGGEDAELGRWPW	PRSS21	41	Q9Y6M0