| Category | Name | IntersectionWithQuery | PValue | GenesInTerm | GenesInQuery | GenesInTermInQuery | ID |
|---|---|---|---|---|---|---|---|
| GeneOntologyMolecularFunction | crossover junction DNA endonuclease activity | 2.73e-06 | 9 | 65 | 3 | GO:0008821 | |
| GeneOntologyMolecularFunction | DNA endonuclease activity, producing 3'-phosphomonoesters | 5.33e-06 | 11 | 65 | 3 | GO:0016889 | |
| GeneOntologyMolecularFunction | endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters | 3.61e-05 | 20 | 65 | 3 | GO:0016894 | |
| GeneOntologyMolecularFunction | flap endonuclease activity | 2.88e-04 | 8 | 65 | 2 | GO:0048256 | |
| GeneOntologyMolecularFunction | DNA endonuclease activity | 3.96e-04 | 44 | 65 | 3 | GO:0004520 | |
| GeneOntologyMolecularFunction | nuclease activity | 9.32e-04 | 231 | 65 | 5 | GO:0004518 | |
| GeneOntologyMolecularFunction | endonuclease activity | 1.01e-03 | 136 | 65 | 4 | GO:0004519 | |
| GeneOntologyMolecularFunction | hydrolase activity, acting on ester bonds | 1.16e-03 | 807 | 65 | 9 | GO:0016788 | |
| GeneOntologyMolecularFunction | DNA nuclease activity | 1.36e-03 | 67 | 65 | 3 | GO:0004536 | |
| GeneOntologyBiologicalProcess | mitotic DNA damage checkpoint signaling | 1.00e-05 | 91 | 65 | 5 | GO:0044773 | |
| GeneOntologyBiologicalProcess | mitotic DNA integrity checkpoint signaling | 1.24e-05 | 95 | 65 | 5 | GO:0044774 | |
| GeneOntologyBiologicalProcess | mitotic intra-S DNA damage checkpoint signaling | 1.97e-05 | 17 | 65 | 3 | GO:0031573 | |
| GeneOntologyBiologicalProcess | DNA damage checkpoint signaling | 6.96e-05 | 136 | 65 | 5 | GO:0000077 | |
| GeneOntologyBiologicalProcess | DNA integrity checkpoint signaling | 9.43e-05 | 145 | 65 | 5 | GO:0031570 | |
| GeneOntologyBiologicalProcess | mitotic cell cycle checkpoint signaling | 1.63e-04 | 163 | 65 | 5 | GO:0007093 | |
| GeneOntologyCellularComponent | Holliday junction resolvase complex | 8.89e-05 | 5 | 63 | 2 | GO:0048476 | |
| GeneOntologyCellularComponent | uniplex complex | 1.33e-04 | 6 | 63 | 2 | GO:1990246 | |
| GeneOntologyCellularComponent | endodeoxyribonuclease complex | 1.33e-04 | 6 | 63 | 2 | GO:1905347 | |
| Domain | ERCC4 | 1.08e-04 | 5 | 62 | 2 | SM00891 | |
| Domain | ERCC4_domain | 1.08e-04 | 5 | 62 | 2 | IPR006166 | |
| Domain | ERCC4 | 1.08e-04 | 5 | 62 | 2 | PF02732 | |
| Domain | JmjC | 2.85e-03 | 24 | 62 | 2 | PF02373 | |
| Domain | VWC | 3.88e-03 | 28 | 62 | 2 | PF00093 | |
| Domain | JMJC | 5.04e-03 | 32 | 62 | 2 | PS51184 | |
| Domain | JmjC_dom | 5.04e-03 | 32 | 62 | 2 | IPR003347 | |
| Domain | JmjC | 5.36e-03 | 33 | 62 | 2 | SM00558 | |
| Domain | VWFC_1 | 6.35e-03 | 36 | 62 | 2 | PS01208 | |
| Domain | VWC | 7.06e-03 | 38 | 62 | 2 | SM00214 | |
| Domain | VWFC_2 | 7.06e-03 | 38 | 62 | 2 | PS50184 | |
| Pathway | KEGG_MEDICUS_REFERENCE_DOUBLE_HOLLIDAY_JUNCTION_RESOLUTION | 1.62e-04 | 6 | 47 | 2 | M47839 | |
| Pathway | REACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES | 2.11e-04 | 35 | 47 | 3 | MM15293 | |
| Pathway | REACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES | 2.49e-04 | 37 | 47 | 3 | M27583 | |
| Pathway | REACTOME_FANCONI_ANEMIA_PATHWAY | 2.92e-04 | 39 | 47 | 3 | MM15318 | |
| Pathway | REACTOME_FANCONI_ANEMIA_PATHWAY | 2.92e-04 | 39 | 47 | 3 | M14990 | |
| Pathway | REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_NUCLEUS | 4.81e-04 | 10 | 47 | 2 | M27095 | |
| Pathway | REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_NUCLEUS | 4.81e-04 | 10 | 47 | 2 | MM14778 | |
| Pathway | REACTOME_REGULATION_OF_LOCALIZATION_OF_FOXO_TRANSCRIPTION_FACTORS | 7.03e-04 | 12 | 47 | 2 | MM15657 | |
| Pathway | REACTOME_REGULATION_OF_LOCALIZATION_OF_FOXO_TRANSCRIPTION_FACTORS | 7.03e-04 | 12 | 47 | 2 | M27939 | |
| Pubmed | A dual-activity topoisomerase complex regulates mRNA translation and turnover. | TYK2 PLCD3 NHSL1 SCAF1 ARAP3 CANT1 TMEM8B SPEG RNPEPL1 CTDP1 HELZ2 MUS81 ARHGEF2 KDM6B COMTD1 WNK2 HR | 4.90e-11 | 1105 | 70 | 17 | 35748872 |
| Pubmed | 9.28e-07 | 10 | 70 | 3 | 35302860 | ||
| Pubmed | 3.99e-06 | 2 | 70 | 2 | 24692662 | ||
| Pubmed | 3.99e-06 | 2 | 70 | 2 | 24813886 | ||
| Pubmed | 3.99e-06 | 2 | 70 | 2 | 35290797 | ||
| Pubmed | Identification and characterization of the human mus81-eme1 endonuclease. | 1.20e-05 | 3 | 70 | 2 | 12721304 | |
| Pubmed | 1.20e-05 | 3 | 70 | 2 | 21388494 | ||
| Pubmed | 1.20e-05 | 3 | 70 | 2 | 26804904 | ||
| Pubmed | 1.20e-05 | 3 | 70 | 2 | 36075446 | ||
| Pubmed | 2.39e-05 | 4 | 70 | 2 | 16326148 | ||
| Pubmed | Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia. | 3.98e-05 | 5 | 70 | 2 | 21240276 | |
| Pubmed | Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4. | 3.98e-05 | 5 | 70 | 2 | 23093618 | |
| Pubmed | 3.98e-05 | 5 | 70 | 2 | 24076219 | ||
| Pubmed | Coordinated actions of SLX1-SLX4 and MUS81-EME1 for Holliday junction resolution in human cells. | 3.98e-05 | 5 | 70 | 2 | 24076221 | |
| Pubmed | FoxO transcription factors; Regulation by AKT and 14-3-3 proteins. | 5.96e-05 | 6 | 70 | 2 | 21708191 | |
| Pubmed | SLX4-SLX1 Protein-independent Down-regulation of MUS81-EME1 Protein by HIV-1 Viral Protein R (Vpr). | 5.96e-05 | 6 | 70 | 2 | 27354282 | |
| Pubmed | SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres. | 5.96e-05 | 6 | 70 | 2 | 24012755 | |
| Pubmed | FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf. | 5.96e-05 | 6 | 70 | 2 | 17974917 | |
| Pubmed | RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity. | 5.96e-05 | 6 | 70 | 2 | 22579284 | |
| Pubmed | Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair. | 8.33e-05 | 7 | 70 | 2 | 19595721 | |
| Pubmed | 1.11e-04 | 8 | 70 | 2 | 19596236 | ||
| Pubmed | A mitochondrial protein compendium elucidates complex I disease biology. | 2.46e-04 | 1047 | 70 | 9 | 18614015 | |
| Pubmed | 2.60e-04 | 12 | 70 | 2 | 10482239 | ||
| Pubmed | Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. | 2.71e-04 | 283 | 70 | 5 | 18854154 | |
| Pubmed | Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM. | 4.12e-04 | 15 | 70 | 2 | 17289582 | |
| Pubmed | SLX4 interacts with RTEL1 to prevent transcription-mediated DNA replication perturbations. | 4.12e-04 | 15 | 70 | 2 | 32398829 | |
| Pubmed | 4.71e-04 | 16 | 70 | 2 | 16376864 | ||
| Pubmed | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. | 5.38e-04 | 926 | 70 | 8 | 20877624 | |
| Pubmed | PLCD3 PPP1R10 SCAF1 TRIM25 MBD1 HELZ2 WHAMM ARHGEF2 COMTD1 N4BP3 | 7.99e-04 | 1497 | 70 | 10 | 31527615 | |
| Pubmed | 8.18e-04 | 21 | 70 | 2 | 32939012 | ||
| Pubmed | FOXO Transcription Factors Are Required for Normal Somatotrope Function and Growth. | 1.07e-03 | 24 | 70 | 2 | 34971379 | |
| Pubmed | 1.18e-03 | 228 | 70 | 4 | 30471916 | ||
| Pubmed | PPP1R10 SCAF1 TRIM25 STARD9 HELZ2 MRPL58 ARHGEF2 ECHS1 MTFMT | 1.68e-03 | 1371 | 70 | 9 | 36244648 | |
| Pubmed | 1.98e-03 | 650 | 70 | 6 | 38777146 | ||
| Pubmed | Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. | 1.99e-03 | 1136 | 70 | 8 | 34800366 | |
| Interaction | TOP3B interactions | TYK2 PLCD3 NHSL1 SCAF1 TRIM25 ARAP3 CANT1 TMEM8B SPEG RNPEPL1 CTDP1 HELZ2 MUS81 ARHGEF2 KDM6B COMTD1 WNK2 HR | 5.63e-07 | 1470 | 65 | 18 | int:TOP3B |
| GeneFamily | Forkhead boxes | 3.13e-03 | 43 | 35 | 2 | 508 | |
| GeneFamily | DNAJ (HSP40) heat shock proteins|C2 tensin-type domain containing | 4.04e-03 | 49 | 35 | 2 | 584 | |
| Disease | blood tin measurement | 1.30e-03 | 25 | 63 | 2 | EFO_0021530 |
| Peptide | Gene | Start | Entry |
|---|---|---|---|
| EVRCPGPAPLRLLEW | 21 | Q9Y5B0 | |
| PPRRGRDAPPRLWCV | 696 | Q8WWN8 | |
| PGTVRRWNYPPPLCI | 1951 | Q7Z408 | |
| TEPLPAEAPWARRPV | 866 | Q92974 | |
| RDCARRLPPARAWLP | 156 | Q8NCL9 | |
| LCLRVRPPRLWCPHP | 156 | O95388 | |
| RPPRLWCPHPRRVSI | 161 | O95388 | |
| PAWKRLSPCPPTRSP | 391 | Q8N7E2 | |
| LGWCSRRPLRPLPSV | 46 | Q13258 | |
| TRLLPTPGTWRPARP | 11 | Q9NWR8 | |
| ARWCSGRARRPPPQP | 71 | Q5T4W7 | |
| PPPAWLKGPACRAAR | 481 | O15054 | |
| SSRQPWRPPACRSPL | 466 | Q96JJ6 | |
| LWLLCSHRPAPGRPP | 56 | Q8WVQ1 | |
| VRGPLRPPVRCPAWR | 11 | P30084 | |
| RPPVRCPAWRPFASG | 16 | P30084 | |
| ILERAPFWVPTCLPP | 151 | O43593 | |
| PICLRPPRPGLRRQW | 241 | Q9UIS9 | |
| DWCLSPPRPALSPIL | 991 | Q5SYE7 | |
| SRPRSCTWPLPRPEI | 26 | P98177 | |
| RPRSCTWPLPQPDLA | 21 | A8MYZ6 | |
| PAPAPWPRHLLRCVL | 6 | Q9UBG0 | |
| RLLWPPPRVSPPLCA | 6 | Q86XE3 | |
| APSSAWPPRLRPRTC | 76 | I0J062 | |
| SGRPRPDTLTPPWVR | 61 | Q86VX9 | |
| PLPPPRLVATVWARA | 776 | A1KZ92 | |
| AEDPPWPARLLRAPL | 11 | Q7Z449 | |
| WVGPCFPELRRRVPR | 431 | P81408 | |
| PVLCTLRPRGWQPAP | 481 | Q9Y6A2 | |
| PTRLPDRSVAWPCPD | 691 | Q9P278 | |
| PPWRGRREQCLLPPE | 36 | Q86VU5 | |
| GRTPWRCRERPVPAK | 106 | Q9H665 | |
| VWLLPPPARCPRRAL | 16 | Q14197 | |
| PLRLCRLWPRNPPSR | 6 | Q9NNZ3 | |
| HPSCLPRWRGPAPVI | 146 | Q96DP5 | |
| VLPRRVWRDCLPPSL | 136 | Q8NHY5 | |
| TWTKVDIPSPPPRRC | 106 | Q8TBB5 | |
| RWTRASPDPCPRSLP | 116 | A4GXA9 | |
| FAPWCPPCRALLPEL | 476 | Q8IXB1 | |
| RPDPVRPIDPAAWLS | 351 | P54792 | |
| CALPRPWSVPPLRRG | 501 | Q9BYK8 | |
| ERLPISPGPLLRWVP | 71 | Q8NEQ5 | |
| PRAPRLPRRLAWCSI | 41 | P00540 | |
| IGPRSRVWAEPCLLP | 271 | Q9HAU8 | |
| RDSALKTPWRPAPCP | 41 | P59090 | |
| LVPCPPLRRVAVWPV | 101 | Q9BVQ7 | |
| CTKDIIRWPRPASPP | 176 | Q9BX95 | |
| ALWPPLERCFPRLPP | 96 | Q8TF30 | |
| TRVLLEPLRPWACPR | 166 | Q66K80 | |
| EPLRPWACPRLPRSP | 171 | Q66K80 | |
| CREVRVPSPPPREAW | 1766 | Q9P2P6 | |
| PPWIRRRPVVVEPIS | 36 | Q96A35 | |
| PWRSAAPEEPERLPL | 1476 | Q9Y566 | |
| ELPAPRRLRWKCSPE | 476 | P28329 | |
| RRRRSCSPAPTWPPL | 61 | Q9H7T3 | |
| SLRCPPVELPWAPRR | 16 | Q9BU61 | |
| RPIPELLRAPPERVW | 1891 | Q15772 | |
| WRRCRRPPEEPPVAA | 6 | Q8N3E9 | |
| PLPVPSLLPRLRAWR | 141 | Q9H7N4 | |
| LAREPPADVWTPPAR | 81 | Q14258 | |
| DVAPRLSPVRVWPRP | 16 | Q9H1D0 | |
| PPEHCWPVRPTLRNE | 31 | A6NDV4 | |
| PEAPWPPAPRARACR | 11 | P41273 | |
| PPAPRARACRVLPWA | 16 | P41273 | |
| ACRLFWPRSRPPPAC | 256 | Q71RH2 | |
| PPWARLPLTLRWVRP | 121 | Q9BQ83 | |
| RWVRPDLRQDLCLPP | 131 | Q9BQ83 | |
| PCRGLTLPCLPWRRA | 1346 | Q9Y3S1 | |
| WVCPRPLVLPSPLVT | 461 | Q96QC0 | |
| RTCWPALPRDRTPAP | 131 | Q96NR7 | |
| WPERVPRLLAPRLPS | 6 | Q6SJ96 | |
| VVERLRAAPVPPLCW | 201 | Q66K66 | |
| ERVERIPWLAPECLP | 771 | P29597 | |
| EPEELVRCRSPWRPG | 126 | Q6NSI3 | |
| GRDRTCIPPRLPPEW | 51 | Q8NHV5 | |
| CIPPRLPPEWVTTLF | 56 | Q8NHV5 | |
| RPLPACPNPLFVRWL | 11 | Q96NY9 | |
| RALREPPTPWSPRLE | 526 | O15049 |