Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionstore-operated calcium channel activity

TRPC7 TRPC3 TRPC6

9.66e-0612723GO:0015279
GeneOntologyMolecularFunctioninositol 1,4,5 trisphosphate binding

TRPC7 TRPC3 TRPC6

1.59e-0514723GO:0070679
GeneOntologyMolecularFunctioninositol-1,4,5-trisphosphate 5-phosphatase activity

SYNJ1 INPP5B

3.54e-048722GO:0052658
GeneOntologyMolecularFunctionphosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

SYNJ1 INPP5B

5.66e-0410722GO:0004439
MousePhenoabnormal single-positive T cell number

COPA ZNF335 DOCK10 PKNOX1 ATM

2.70e-0584595MP:0008081
DomainTRP_dom

TRPC7 TRPC3 TRPC6

1.14e-066733IPR013555
DomainTRP_2

TRPC7 TRPC3 TRPC6

1.14e-066733PF08344
DomainTRPC_channel

TRPC7 TRPC3 TRPC6

1.98e-067733IPR002153
DomainTRP_channel

TRPC7 TRPC3 TRPC6

9.24e-0611733IPR004729
Domain-

GTF2IRD2B GTF2IRD2

9.00e-0547323.90.1460.10
DomainVPS13_C

VPS13C VPS13B

9.00e-054732PF16909
DomainGTF2I

GTF2IRD2B GTF2IRD2

9.00e-054732PS51139
DomainSHR-BD

VPS13C VPS13B

9.00e-054732IPR009543
DomainGTF2I

GTF2IRD2B GTF2IRD2

9.00e-054732PF02946
DomainVPS13_C

VPS13C VPS13B

9.00e-054732IPR031645
DomainGTF2I

GTF2IRD2B GTF2IRD2

9.00e-054732IPR004212
DomainSHR-BD

VPS13C VPS13B

9.00e-054732PF06650
DomainATG_C

VPS13C VPS13B

1.50e-045732PF09333
DomainZnf_FCS

PHC3 PHC1

1.50e-045732IPR012313
DomainAutophagy-rel_C

VPS13C VPS13B

1.50e-045732IPR015412
DomainZF_FCS

PHC3 PHC1

2.24e-046732PS51024
DomainVPS13_N

VPS13C VPS13B

4.16e-048732IPR026854
DomainChorein_N

VPS13C VPS13B

4.16e-048732PF12624
DomainIPPc

SYNJ1 INPP5B

6.64e-0410732IPR000300
DomainIPPc

SYNJ1 INPP5B

6.64e-0410732SM00128
DomainDOCK_C

DOCK5 DOCK10

8.10e-0411732IPR010703
DomainDHR-1_domain

DOCK5 DOCK10

8.10e-0411732IPR027007
DomainDHR_2

DOCK5 DOCK10

8.10e-0411732PS51651
DomainDHR_1

DOCK5 DOCK10

8.10e-0411732PS51650
DomainDOCK-C2

DOCK5 DOCK10

8.10e-0411732PF14429
DomainDHR-2

DOCK5 DOCK10

8.10e-0411732IPR027357
DomainDHR-2

DOCK5 DOCK10

8.10e-0411732PF06920
DomainDOCK

DOCK5 DOCK10

8.10e-0411732IPR026791
DomainZnf_C2H2-like

ZNF182 GTF2IRD2B ZBTB38 ZNF148 RNF125 ZNF335 SNAI2 GTF2IRD2 ZNF236 ZNF681

1.02e-037967310IPR015880
DomainZnF_C2H2

ZNF182 GTF2IRD2B ZBTB38 ZNF148 RNF125 ZNF335 SNAI2 GTF2IRD2 ZNF236 ZNF681

1.14e-038087310SM00355
DomainTPR_8

TTC39B NAA15 CFAP70

1.17e-0353733PF13181
DomainPI3/4_kinase_CS

PI4KA ATM

1.53e-0315732IPR018936
Domain-

PI4KA ATM

1.75e-03167321.10.1070.11
DomainPI3Kc

PI4KA ATM

1.75e-0316732SM00146
DomainPI3/4_kinase_cat_dom

PI4KA ATM

2.21e-0318732IPR000403
DomainPI3_PI4_kinase

PI4KA ATM

2.21e-0318732PF00454
DomainPI3_4_KINASE_3

PI4KA ATM

2.21e-0318732PS50290
DomainPI3_4_KINASE_1

PI4KA ATM

2.21e-0318732PS00915
DomainPI3_4_KINASE_2

PI4KA ATM

2.21e-0318732PS00916
DomainSH3_9

FNBP1 ITSN2 NEB

3.53e-0378733PF14604
DomainSH3_1

DOCK5 FNBP1 ITSN2 NEB

3.90e-03164734PF00018
DomainMetalloPept_cat_dom

PHEX ADAMTS3 ADAM17

3.93e-0381733IPR024079
Domain-

PHEX ADAMTS3 ADAM17

3.93e-03817333.40.390.10
Domain-

SYNJ1 INPP5B

4.61e-03267323.60.10.10
DomainExo_endo_phos

SYNJ1 INPP5B

4.61e-0326732PF03372
DomainEndo/exonuclease/phosphatase

SYNJ1 INPP5B

4.96e-0327732IPR005135
DomainZINC_PROTEASE

PHEX ADAMTS3 ADAM17

6.68e-0398733PS00142
PathwayREACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN_1_SIGNALING

TRPC7 TRPC3 TRPC6

4.37e-0610483M27330
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

TRPC7 TRPC3 TRPC6

1.03e-0513483MM14553
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

TRPC7 TRPC3 TRPC6

2.01e-0516483M26945
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

TRPC7 TRPC3 TRPC6

8.08e-0525483MM14511
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

TRPC7 TRPC3 TRPC6

1.02e-0427483M12123
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

TRPC7 TRPC3 TRPC6

1.02e-0427483MM15053
PathwayREACTOME_TRP_CHANNELS

TRPC7 TRPC3 TRPC6

1.14e-0428483MM14943
PathwayREACTOME_TRP_CHANNELS

TRPC7 TRPC3 TRPC6

1.14e-0428483M27241
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

TRPC7 TRPC3 TRPC6

1.14e-0428483M924
PathwayREACTOME_NETRIN_1_SIGNALING

TRPC7 TRPC3 TRPC6

4.45e-0444483M875
PathwayREACTOME_SYNTHESIS_OF_IP2_IP_AND_INS_IN_THE_CYTOSOL

SYNJ1 INPP5B

7.33e-0412482MM14710
PathwayKEGG_INOSITOL_PHOSPHATE_METABOLISM

SYNJ1 INPP5B PI4KA

8.14e-0454483M3896
PathwayREACTOME_SYNTHESIS_OF_IP2_IP_AND_INS_IN_THE_CYTOSOL

SYNJ1 INPP5B

1.01e-0314482M27052
PathwayREACTOME_REGULATION_OF_PTEN_GENE_TRANSCRIPTION

PHC3 SNAI2 PHC1

1.16e-0361483M27811
Pubmed

Major contribution of the 3/6/7 class of TRPC channels to myocardial ischemia/reperfusion and cellular hypoxia/reoxygenation injuries.

TRPC7 TRPC3 TRPC6

9.25e-09374328526717
Pubmed

Melanopsin Phototransduction Is Repurposed by ipRGC Subtypes to Shape the Function of Distinct Visual Circuits.

TRPC7 TRPC3 TRPC6

3.69e-08474330017393
Pubmed

TRPC channels are necessary mediators of pathologic cardiac hypertrophy.

TRPC7 TRPC3 TRPC6

9.22e-08574320351294
Pubmed

Intrinsic phototransduction persists in melanopsin-expressing ganglion cells lacking diacylglycerol-sensitive TRPC subunits.

TRPC7 TRPC3 TRPC6

9.22e-08574321261756
Pubmed

MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC.

TRPC7 TRPC3 TRPC6

3.22e-07774315757897
Pubmed

RNA-seq analysis reveals TRPC genes to impact an unexpected number of metabolic and regulatory pathways.

TRPC7 TRPC3 TRPC6

3.22e-07774332350291
Pubmed

TRPC absence induces pro-inflammatory macrophages and gut microbe disorder, sensitizing mice to colitis.

TRPC7 TRPC3 TRPC6

3.22e-07774336592529
Pubmed

Functional role of TRPC proteins in vivo: lessons from TRPC-deficient mouse models.

TRPC7 TRPC3 TRPC6

3.22e-07774315336983
Pubmed

TRPC absence induces pro-inflammatory macrophage polarization to promote obesity and exacerbate colorectal cancer.

TRPC7 TRPC3 TRPC6

3.22e-07774338835669
Pubmed

Subunit composition, molecular environment, and activation of native TRPC channels encoded by their interactomes.

TRPC7 TRPC3 TRPC6

3.22e-07774336257322
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

FNBP1 PHC3 AREL1 ZNF182 SYNJ1 ACAD9 INPP5B PI4KA ADAM17 DOT1L PARPBP CPLANE1 VPS13B

4.38e-071084741311544199
Pubmed

Subunit composition of mammalian transient receptor potential channels in living cells.

TRPC7 TRPC3 TRPC6

5.14e-07874312032305
Pubmed

Metabolism regulates the spontaneous firing of substantia nigra pars reticulata neurons via KATP and nonselective cation channels.

TRPC7 TRPC3 TRPC6

5.14e-07874325471572
Pubmed

Association of immunophilins with mammalian TRPC channels.

TRPC7 TRPC3 TRPC6

5.14e-07874315199065
Pubmed

Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels.

TRPC7 TRPC3 TRPC6

7.70e-07974311290752
Pubmed

Cellular subtype distribution and developmental regulation of TRPC channel members in the mouse dorsal root ganglion.

TRPC7 TRPC3 TRPC6

7.70e-07974317480026
Pubmed

Heterogeneous distribution of TRPC proteins in the embryonic cortex.

TRPC7 TRPC3 TRPC6

1.10e-061074318989690
Pubmed

The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons.

TRPC7 TRPC3 TRPC6

1.10e-061074327177420
Pubmed

Melanopsin signalling in mammalian iris and retina.

TRPC7 TRPC3 TRPC6

2.60e-061374322051675
Pubmed

Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol.

TRPC3 TRPC6

4.47e-0627429930701
Pubmed

TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells.

TRPC3 TRPC6

4.47e-06274222724068
Pubmed

DC-STAMP and TACE Levels are Higher in Patients with Periodontitis.

ADAM17 DCST1

4.47e-06274232556010
Pubmed

Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy.

TRPC3 TRPC6

4.47e-06274224453217
Pubmed

Modulation of Transient Receptor Potential Channels 3 and 6 Regulates Osteoclast Function with Impact on Trabecular Bone Loss.

TRPC3 TRPC6

4.47e-06274232140760
Pubmed

[Mechanism of cardiac hypertrophy via diacylglycerol-sensitive TRPC channels].

TRPC3 TRPC6

4.47e-06274220190513
Pubmed

ATM, the Mre11/Rad50/Nbs1 complex, and topoisomerase I are concentrated in the nucleus of Purkinje neurons in the juvenile human brain.

ATM TOP1

4.47e-06274217706468
Pubmed

Upregulation and Diverse Roles of TRPC3 and TRPC6 in Synaptic Reorganization of the Mossy Fiber Pathway in Temporal Lobe Epilepsy.

TRPC3 TRPC6

4.47e-06274225213992
Pubmed

Differences in TRPC3 and TRPC6 channels assembly in mesenteric vascular smooth muscle cells in essential hypertension.

TRPC3 TRPC6

4.47e-06274227861908
Pubmed

Structure of the receptor-activated human TRPC6 and TRPC3 ion channels.

TRPC3 TRPC6

4.47e-06274229700422
Pubmed

Transient receptor potential channels function as a coincidence signal detector mediating phosphatidylserine exposure.

TRPC3 TRPC6

4.47e-06274223800468
Pubmed

TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca2+ concentration in mouse cardiomyocytes.

TRPC3 TRPC6

4.47e-06274228105583
Pubmed

Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.

TRPC3 TRPC6

4.47e-06274235051376
Pubmed

ATM deficiency results in accumulation of DNA-topoisomerase I covalent intermediates in neural cells.

ATM TOP1

4.47e-06274223626666
Pubmed

Diacylglycerol-containing oleic acid induces increases in [Ca(2+)](i) via TRPC3/6 channels in human T-cells.

TRPC3 TRPC6

4.47e-06274222306362
Pubmed

[Regulation of cardiac hypertrophy by the formation of G protein-coupled receptor--TRPC channel protein complex].

TRPC3 TRPC6

4.47e-06274219749484
Pubmed

Cloning and expression of a novel mammalian homolog of Drosophila transient receptor potential (Trp) involved in calcium entry secondary to activation of receptors coupled by the Gq class of G protein.

TRPC3 TRPC6

4.47e-0627429368034
Pubmed

Comparison of TFII-I gene family members deleted in Williams-Beuren syndrome.

GTF2IRD2B GTF2IRD2

4.47e-06274215388857
Pubmed

Molecular determinants for cardiovascular TRPC6 channel regulation by Ca2+/calmodulin-dependent kinase II.

TRPC7 TRPC6

4.47e-06274223529130
Pubmed

DHA induces Jurkat T-cell arrest in G2/M phase of cell cycle and modulates the plasma membrane expression of TRPC3/6 channels.

TRPC3 TRPC6

4.47e-06274233333171
Pubmed

A TRPC3/6 Channel Inhibitor Promotes Arteriogenesis after Hind-Limb Ischemia.

TRPC3 TRPC6

4.47e-06274235805125
Pubmed

N-linked protein glycosylation is a major determinant for basal TRPC3 and TRPC6 channel activity.

TRPC3 TRPC6

4.47e-06274212970363
Pubmed

PLC-mediated PI(4,5)P2 hydrolysis regulates activation and inactivation of TRPC6/7 channels.

TRPC7 TRPC6

4.47e-06274224470487
Pubmed

Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation.

TRPC7 TRPC3 TRPC6

6.15e-061774322411552
Pubmed

Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells.

TRPC7 TRPC3 TRPC6

1.20e-052174330270038
Pubmed

Calcium sensing receptor modulates extracellular calcium entry and proliferation via TRPC3/6 channels in cultured human mesangial cells.

TRPC3 TRPC6

1.34e-05374224905090
Pubmed

TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice.

TRPC3 TRPC6

1.34e-05374228790356
Pubmed

Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination.

ATM TOP1

1.34e-05374233450211
Pubmed

Selective association of TRPC channel subunits in rat brain synaptosomes.

TRPC3 TRPC6

1.34e-05374212377790
Pubmed

The Effect and Mechanism of TRPC1, 3, and 6 on the Proliferation, Migration, and Lumen Formation of Retinal Vascular Endothelial Cells Induced by High Glucose.

TRPC3 TRPC6

1.34e-05374232097940
Pubmed

Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho.

TRPC3 TRPC6

1.34e-05374227979597
Pubmed

Isolation and characterisation of GTF2IRD2, a novel fusion gene and member of the TFII-I family of transcription factors, deleted in Williams-Beuren syndrome.

GTF2IRD2B GTF2IRD2

1.34e-05374215100712
Pubmed

Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native store-operated channels in HEK-293 cells.

TRPC7 TRPC3

1.34e-05374215972814
Pubmed

Deletion of classical transient receptor potential 1, 3 and 6 alters pulmonary vasoconstriction in chronic hypoxia-induced pulmonary hypertension in mice.

TRPC3 TRPC6

1.34e-05374236569761
Pubmed

Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2.

TRPC3 TRPC6

1.34e-05374223938296
Pubmed

Zoledronate-induced S phase arrest and apoptosis accompanied by DNA damage and activation of the ATM/Chk1/cdc25 pathway in human osteosarcoma cells.

RASGRF1 ATM

1.34e-05374217611684
Pubmed

Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry.

TRPC3 TRPC6

1.34e-05374210611319
Pubmed

Canonical transient receptor potential channel (TRPC)3 and TRPC6 associate with large-conductance Ca2+-activated K+ (BKCa) channels: role in BKCa trafficking to the surface of cultured podocytes.

TRPC3 TRPC6

1.34e-05374219052171
Pubmed

Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension.

TRPC3 TRPC6

1.34e-05374215358862
Pubmed

The transient receptor potential (TRP) channel TRPC3 TRP domain and AMP-activated protein kinase binding site are required for TRPC3 activation by erythropoietin.

TRPC3 TRPC6

1.34e-05374221757714
Pubmed

Recruitment of ataxia-telangiectasia mutated to the p21(waf1) promoter by ZBP-89 plays a role in mucosal protection.

ZNF148 ATM

1.34e-05374216952553
Pubmed

Orai proteins interact with TRPC channels and confer responsiveness to store depletion.

TRPC3 TRPC6

1.34e-05374217360584
Pubmed

A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7.

TRPC7 TRPC3

1.34e-05374219812035
Pubmed

The Retinal Basis of Light Aversion in Neonatal Mice.

TRPC7 TRPC6

1.34e-05374235396331
Pubmed

TRPC3 activation by erythropoietin is modulated by TRPC6.

TRPC3 TRPC6

1.34e-05374219074769
Pubmed

Mapping the expression of transient receptor potential channels across murine placental development.

TRPC7 TRPC3 TRPC6

1.81e-052474333884443
Pubmed

International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.

TRPC7 TRPC3 TRPC6

2.06e-052574316382100
Pubmed

An introduction to TRP channels.

TRPC7 TRPC3 TRPC6

2.61e-052774316460286
Pubmed

Analysis of the human VPS13 gene family.

VPS13C VPS13B

2.67e-05474215498460
Pubmed

Selective interference with TRPC3/6 channels disrupts OX1 receptor signalling via NCX and reveals a distinct calcium influx pathway.

TRPC3 TRPC6

2.67e-05474220728215
Pubmed

TFII-I gene family during tooth development: candidate genes for tooth anomalies in Williams syndrome.

GTF2IRD2B GTF2IRD2

2.67e-05474217823943
Pubmed

Evolution of general transcription factors.

GTF2IRD2B GTF2IRD2

2.67e-05474223229069
Pubmed

Dynamic interaction of hTRPC6 with the Orai1-STIM1 complex or hTRPC3 mediates its role in capacitative or non-capacitative Ca(2+) entry pathways.

TRPC3 TRPC6

2.67e-05474219260825
Pubmed

GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members.

GTF2IRD2B GTF2IRD2

2.67e-05474222899722
Pubmed

Molecular identification and localization of Trp homologues, putative calcium channels, in pregnant human uterus.

TRPC3 TRPC6

2.67e-05474212356946
Pubmed

The role of cGMP/cGKI signalling and Trpc channels in regulation of vascular tone.

TRPC3 TRPC6

2.67e-05474223832809
Pubmed

The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing.

TRPC3 TRPC6

2.67e-05474226520460
Pubmed

Pulsatile atheroprone shear stress affects the expression of transient receptor potential channels in human endothelial cells.

TRPC3 TRPC6

2.67e-05474222566504
Pubmed

Haploinsufficiency of Gtf2i, a gene deleted in Williams Syndrome, leads to increases in social interactions.

GTF2IRD2B GTF2IRD2

2.67e-05474221328569
Pubmed

TRPC1- and TRPC3-dependent Ca2+ signaling in mouse cortical astrocytes affects injury-evoked astrogliosis in vivo.

TRPC3 TRPC6

2.67e-05474228636132
Pubmed

Formation of novel TRPC channels by complex subunit interactions in embryonic brain.

TRPC3 TRPC6

4.45e-05574212857742
Pubmed

Enhanced capacitative calcium entry and TRPC channel gene expression in human LES smooth muscle.

TRPC3 TRPC6

4.45e-05574212736151
Pubmed

Store-operated Ca2+ entry and Ca2+ responses to hypothalamic releasing hormones in anterior pituitary cells from Orai1-/- and heptaTRPC knockout mice.

TRPC3 TRPC6

4.45e-05574230452936
Pubmed

A cardiac pathway of cyclic GMP-independent signaling of guanylyl cyclase A, the receptor for atrial natriuretic peptide.

TRPC3 TRPC6

4.45e-05574222027011
Pubmed

Hyperactive adverse mechanical stress responses in dystrophic heart are coupled to transient receptor potential canonical 6 and blocked by cGMP-protein kinase G modulation.

TRPC3 TRPC6

4.45e-05574224449818
Pubmed

Store-operated Ca2+ channels formed by TRPC1, TRPC6 and Orai1 and non-store-operated channels formed by TRPC3 are involved in the regulation of NADPH oxidase in HL-60 granulocytes.

TRPC3 TRPC6

4.45e-05574218436303
Pubmed

TRPC3 channels are required for synaptic transmission and motor coordination.

TRPC3 TRPC6

4.45e-05574218701065
Pubmed

A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.

TRPC7 TRPC3 TRPC6

4.82e-053374319834762
Pubmed

Calcium Channels Formed by Mammalian Trp Homologues.

TRPC3 TRPC6

6.66e-05674211390792
Pubmed

Tumor-associated MICA is shed by ADAM proteases.

KLRK1 ADAM17

6.66e-05674218676862
Pubmed

trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry.

TRPC3 TRPC6

6.66e-0567428646775
Pubmed

Transient receptor potential channels and their role in modulating radial glial-neuronal interaction: a signaling pathway involving mGluR5.

TRPC3 TRPC6

6.66e-05674225347706
Pubmed

TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations.

TRPC3 TRPC6

6.66e-05674232414784
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

TRPC7 TRPC3 TRPC6

7.39e-053874330786075
Pubmed

Mechanism of stretch-induced activation of the mechanotransducer zyxin in vascular cells.

TRPC3 TRPC6

9.31e-05774223233529
Pubmed

Coexistence within one cell of microvillous and ciliary phototransductions across M1- through M6-IpRGCs.

TRPC7 TRPC6

9.31e-05774238109525
Pubmed

EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis?

SYNJ1 ITSN2

9.31e-05774210373452
Pubmed

Identification of Annexin A4 as a hepatopancreas factor involved in liver cell survival.

ANXA4 PROX1

9.31e-05774225176043
Pubmed

Pkd1 and Wnt5a genetically interact to control lymphatic vascular morphogenesis in mice.

RYK PROX1

9.31e-05774234174014
Pubmed

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.

VWA3A IBTK RNF125 SPATA6 TRPC6 SLCO1B1 PADI2 VPS13B

1.05e-0468674829987050
Pubmed

Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.

TRPC7 TRPC3 TRPC6

1.15e-044474319322198
InteractionTRPC7 interactions

TRPC7 TRPC3 TRPC6

8.68e-076723int:TRPC7
GeneFamilyTransient receptor potential cation channels

TRPC7 TRPC3 TRPC6

6.59e-0528513249
GeneFamilyCD molecules|C-type lectin domain family|Killer cell lectin like receptors

KLRK1 KLRF2

5.06e-0412512621
GeneFamilyPhosphoinositide phosphatases

SYNJ1 INPP5B

3.67e-03325121079
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF182 ZBTB38 ZNF148 ZNF335 SNAI2 ZNF236 ZNF681

3.83e-0371851728
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

KLRK1 KLRF2

5.96e-03415121298
GeneFamilyBasic leucine zipper proteins|BTB domain containing

KLHL2 IBTK ZBTB38

6.40e-03134513861
CoexpressionGSE13485_CTRL_VS_DAY1_YF17D_VACCINE_PBMC_DN

VWA3A ADAD1 CNNM2 TRPC7 OMD ZNF236 DCST1

9.07e-07184747M3281
CoexpressionHAMAI_APOPTOSIS_VIA_TRAIL_UP

FNBP1 ZBTB38 NAA15 ZNF148 VPS13C ITSN2 DOCK10 ATM PARPBP CPLANE1

1.53e-056567410M18979
CoexpressionZHENG_FOXP3_TARGETS_IN_THYMUS_UP

TTC39B IBTK RNF125 DOCK10 TOP1 GALNT4

2.14e-05199746M1746
CoexpressionGSE27786_LSK_VS_NEUTROPHIL_DN

KLRK1 KLHL2 AREL1 COPA ZNF236 G6PC1

2.20e-05200746M4761
CoexpressionGSE19888_ADENOSINE_A3R_INH_VS_TCELL_MEMBRANES_ACT_MAST_CELL_UP

AREL1 SLC35D3 CCDC18 GTF2IRD2 ATM MX2

2.20e-05200746M7324
CoexpressionZHENG_FOXP3_TARGETS_IN_THYMUS_UP

TTC39B IBTK RNF125 DOCK10 TOP1 GALNT4

2.20e-05200746MM1033
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

DOCK5 SPATA6 TRPC3 TRPC6 DOCK10 UNC13C PCDH7

3.50e-08194747b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

TRPC3 TRPC6 SNAI2 DOCK10 UNC13C PCDH7

8.64e-07194746a3e5a15cf6c1361207f661ee15eb634f77daf1cb
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

DOCK5 TRPC3 TRPC6 DOCK10 UNC13C PCDH7

8.90e-071957460e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBTB38 RNF125 VPS13C ITSN2 MX2

1.18e-0517874501dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellControl-T_cells-CD8+_T_cells|Control / group, cell type (main and fine annotations)

KLRK1 FNBP1 RNF125 DOCK10 ATM

1.43e-0518574502ab64c0166c0646d1d4c6ed110ef0b75a1096d0
ToppCellControl-T_cells|Control / group, cell type (main and fine annotations)

KLRK1 FNBP1 RNF125 DOCK10 ATM

1.50e-05187745f4e8e0eba58da89b56587667555a5d4754e108c7
ToppCellLA-13._Vascular_Smooth_Muscle|LA / Chamber and Cluster_Paper

FNBP1 CNNM2 DOCK10 UNC13C PCDH7

1.54e-0518874534e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PHEX VWA3A SPATA6 UNC13C PCDH7

1.58e-05189745203c80030df08ae112f9ae4043709f455d87ce89
ToppCellLA-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

FNBP1 CNNM2 DOCK10 UNC13C PCDH7

1.58e-051897456b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L6_LAMP5_C1QL2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK5 TRPC3 DOCK10 UNC13C PROX1

1.75e-0519374564a37dae3d631713b06d94691f5dcdb200dfef5e
ToppCellPCW_13-14-Mesenchymal|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SPATA6 SNAI2 DOCK10 UNC13C PCDH7

1.93e-0519774573a2085d2682d636726a5432d572ae2a3fbe1c3f
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SPATA6 SNAI2 DOCK10 UNC13C PCDH7

1.93e-051977450034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SPATA6 SNAI2 DOCK10 UNC13C PCDH7

1.93e-0519774511a4c417f035e554431a8f03be13b5eefa3530c0
ToppCellTCGA-Skin-Metastatic-Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

PHC3 ZBTB38 ZNF148 VPS13C TOP1

1.98e-05198745af4fb9eb2295c7b90624b38ba25619aa15254efa
ToppCellTCGA-Skin-Metastatic|TCGA-Skin / Sample_Type by Project: Shred V9

PHC3 ZBTB38 ZNF148 VPS13C TOP1

1.98e-05198745ad39cce004867f083f8da1954e0cf5a263815184
ToppCellSevere-B_intermediate-10|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

PHEX VPS13C ANXA4 NEB MX2

1.98e-05198745dfae26c3513a82bb7cb8dadbfcea2a1f420b1bab
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

PHC3 ZBTB38 ZNF148 VPS13C TOP1

1.98e-0519874562cbf4b29e8af4983fb47a17f96da62682a5137e
ToppCellGlobus_pallidus|World / BrainAtlas - Mouse McCarroll V32

SLC35D3 DOCK10 UNC13C DOT1L

5.80e-0512674444b63f945d5bedf1a2ca1810e7e100276ea9dd89
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c03-MKI67|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

SNX31 CFAP70 PADI2 PROX1

1.03e-04146744c0e1836845c083bf9d88a620da27acbfdea9fb20
ToppCellfacs-MAT-Fat-24m-Lymphocytic-NK_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLRK1 AREL1 GTF2IRD2 PADI2

1.20e-04152744fa03262e2853b7d35ef8cdbb652930abad90563c
ToppCellnormal-na-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

HHLA2 ZBTB38 RNF125 ATM

1.29e-0415574408295584395e8d9cfc1b1648f98754b3ac53e587
ToppCellfacs-BAT-Fat-24m-Lymphocytic-NK_cell|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLRK1 SNX31 GLRX2 PADI2

1.29e-04155744550e7e7e52829244ead829e5be010bfdc71e2ba5
ToppCelldroplet-Kidney-nan-18m-Lymphocytic-NK_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLRK1 RNF125 DOCK10 PADI2

1.46e-04160744398f162e8a75c6cb5c3e4d1832e98d386e1f222b
ToppCelldroplet-Kidney-nan-18m-Lymphocytic-CD45____NK_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLRK1 RNF125 DOCK10 PADI2

1.46e-0416074412aaab0291035f578e2433efd169ae72f393a5a5
ToppCell10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8|blood / Manually curated celltypes from each tissue

PHC3 RNF125 DOCK10 ATM

1.53e-04162744b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TRPC6 SNX31 OMD DCST1

1.64e-041657444f83ac71efc57be3668d8db1e62bad05dc6a5e2b
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TRPC6 SNX31 OMD DCST1

1.64e-04165744cd8de98af8a1a8a6c81d71fae807cc07f319f4c9
ToppCellfacs-Limb_Muscle-forelimb_and_hindlimb-18m-Lymphocytic-T_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLRK1 AREL1 DOCK10 PADI2

1.76e-04168744182f08106ac65ea501e2fb9139d3b44b7c4662c9
ToppCellfacs-Marrow-T-cells-3m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VPS13C DOCK10 ADAM17 MX2

1.84e-04170744a78d9789c3e7c84a36e1bd380192d7aba4a4d443
ToppCellfacs-Marrow-T-cells-3m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VPS13C DOCK10 ADAM17 MX2

1.84e-04170744ff68600b945b3a5437b14e5411b3db800d0ccbe5
ToppCellControl-Epithelial_cells-Airway_basal|Control / group, cell type (main and fine annotations)

TRPC6 SNX31 UNC13C PCDH7

1.88e-041717443965ced4be6db14265a90673502fceee425837ca
ToppCell390C-Epithelial_cells-Epithelial-H_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

TRPC6 SNAI2 SNX31 PCDH7

1.93e-04172744bb542f6ca4eb8167129bc84ca1160a54fbb68731
ToppCell390C-Epithelial_cells-Epithelial-H_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

TRPC6 SNAI2 SNX31 PCDH7

1.93e-04172744aff37b9689b0d30ee7097d997d9588efc475c8fd
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic-mature_NK_T_cell|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

KLRK1 RNF125 DOCK10 ATM

1.97e-0417374436a471576a9d2325066bb14c2f2cd89c67b92915
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IBTK ZBTB38 VPS13C PCDH7

2.10e-04176744749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCelldroplet-Kidney-KIDNEY-1m-Lymphocytic-T_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLRK1 RNF125 NEB PADI2

2.15e-0417774436da06ca9577cdb7c7b5114e604f6546b9765c08
ToppCelldroplet-Tongue-nan-24m-Myeloid-basal_cell|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLRK1 RNF125 DOCK10 PADI2

2.20e-041787449423e209de94d26e96117581c95dc069850225d3
ToppCelldroplet-Tongue-nan-24m-Myeloid-nan|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLRK1 RNF125 NXF2 PADI2

2.24e-041797441b079d80f789473701c781f3431ad306e9766797
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

PHEX VWA3A TRPC6 PCDH7

2.34e-041817449ede19228ba5c0668a9c06c915510b95585216ef
ToppCellfacs-Kidney-nan-24m-Lymphocytic-T_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLRK1 FNBP1 RNF125 PADI2

2.39e-04182744e5f62ce9b9e0d28627617f7cbc81026f8442e402
ToppCellfacs-Kidney-nan-24m-Lymphocytic-T_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLRK1 FNBP1 RNF125 PADI2

2.39e-041827440e16824c721d8b7d527157cb65feec909f6b974c
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK5 DOCK10 SLCO1B1 PADI2

2.44e-0418374493213124e55d1b673dd345188caf8b5bd31d99fe
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK5 DOCK10 SLCO1B1 PADI2

2.49e-04184744f6d6b3ddada66dae28d3306415bf4efe0934208a
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L6_LAMP5_C1QL2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRPC3 DOCK10 UNC13C PROX1

2.54e-041857446e7fefdd65d30abaffb26b92b0d04e1630d262ad
ToppCellControl-T_cells-NK_cells|Control / group, cell type (main and fine annotations)

KLRK1 RNF125 DOCK10 ATM

2.54e-04185744755c0998c729f462399f1d5e88adf4bfae31be30
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FNBP1 RNF125 DOCK10 ATM

2.60e-041867449d576dce2c5deefef1adda16c6da7055c8d57f8f
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-T_Cell-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FNBP1 RNF125 DOCK10 ATM

2.60e-04186744bd3bd022b575d9b0ef90d50a5cb874085a827b77
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-T_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FNBP1 RNF125 DOCK10 ATM

2.60e-04186744924cc357b4c4ce8e9b05773bdab544f0b65474cc
ToppCellILEUM-inflamed-(3)_MNP-(3)_moDC|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

DOCK5 COPA ADAM17 ATM

2.65e-041877440099def970fbc828756fbf853eca2ce77b8cd342
ToppCellControl-B_intermediate-6|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

FNBP1 ANXA4 ITSN2 DOCK10

2.76e-0418974411cb9a16f1de8f60af2073ed7ea6d4f41c02f299
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CNNM2 TRPC3 TRPC6 PCDH7

2.76e-041897447ab1cfc1657277858339f7258a0c4ae9cb42fdf8
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRPC3 DOCK10 DNAH14 PROX1

2.76e-04189744f0aaf2994d319a39877d2845eaab9f166adead4e
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

KLRK1 RNF125 DOCK10 ATM

2.76e-04189744e9df7ecd36bee1fedce23bb188c68a94fa60462c
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRPC3 DOCK10 UNC13C PROX1

2.76e-04189744979b7fa947538aa7ca4a219263da2575869a2caa
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.4.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KLRK1 RNF125 DOCK10 ATM

2.81e-04190744d153a0bdedcd6865e6ee19575234a78b5d859ff1
ToppCellPCW_13-14|World / Celltypes from embryonic and fetal-stage human lung

ZBTB38 SPATA6 DOCK10 UNC13C

2.81e-0419074462a3ec1ae0829602b0569cc051210551644f1d46
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRPC3 DOCK10 UNC13C PROX1

2.81e-04190744be2b184a3559da41ba387ae0fdbeb9ae532868a5
ToppCellPSB-critical-LOC-Lymphoid-NK|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KLRK1 RNF125 KLRF2 DOCK10

2.81e-04190744e1b5d76edd4c1b95c0a7b94284a65043ab895e67
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CNNM2 TRPC3 TRPC6 PCDH7

2.87e-0419174408042952431ca1a6fd7dfc13f36eb28643979598
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_GGH|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC35D3 TRPC6 DOCK10 PROX1

2.87e-0419174406760c3bb40e4f66879a5f5e09c9abfce4ebbba3
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CNNM2 TRPC3 TRPC6 PCDH7

2.87e-041917447853ac7dff649150e6ff27cd4c8cf7c1fc034ed4
ToppCellNS-moderate-d_16-33-Lymphoid-Treg|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FNBP1 RNF125 DOCK10 ATM

2.93e-0419274448d557071bad80edd3ec6e5ad8dcd97037da9553
ToppCellFetal_29-31_weeks-Immune-T_lymphocyte|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FNBP1 RNF125 DOCK10 ATM

2.93e-0419274469a2b04f03a1b82d067018379f7b8a116e954040
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CNNM2 TRPC3 TRPC6 PCDH7

2.93e-04192744992d08092edbc68c47b945deb8708379738c239a
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRPC3 DOCK10 UNC13C PROX1

2.93e-0419274463d1b3efe93e5ff939278ebe40bacb38218ea09b
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRPC3 DOCK10 UNC13C PROX1

2.93e-04192744bd3fa6c8fcb618db64d11f25cabaf08608957c35
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRPC3 DOCK10 UNC13C PROX1

2.99e-04193744294cb5b580bb83fe0eb04f112d5507aac35d4d44
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

VWA3A CFAP70 CPLANE1 PCDH7

2.99e-04193744ea345d34440b25f65358a53dc72831998d1c3620
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_T_cell|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TTC39B ZBTB38 RNF125 ATM

2.99e-04193744a594f89a18273797506287d9e22f72abe53e4920
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRPC3 DOCK10 UNC13C PROX1

2.99e-041937443d3c45d5ff6f3396a1990615aae9fe176e799994
ToppCellCOVID-19-kidney-T-cells-1|COVID-19 / Disease (COVID-19 only), tissue and cell type

FNBP1 RNF125 DOCK10 ATM

2.99e-041937445b84fa640cf30dea55fde53b810f850ff946d253
ToppCell10x3'2.3-week_17-19-Mesenchymal_myocytic-stroma-myofibroblast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

SPATA6 NEB PCDH7 PROX1

2.99e-0419374402dfd1df1e7fc84bfca2b0c95138b5b4408bb5d1
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PHEX SPATA6 UNC13C PCDH7

3.05e-04194744011e14d9ed1393275f892060e7708ffadcd0767f
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRPC3 DOCK10 UNC13C PROX1

3.05e-0419474452aebb0b563e2c2058e7f0554ae870e47692b163
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

PHEX SPATA6 SNAI2 PCDH7

3.05e-0419474471d3c7448b1734de54187f902f65649f9283bd4c
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRPC3 DOCK10 UNC13C PROX1

3.05e-04194744bd06e2b8d8c06cddf2e4f58849b86e09013acae1
ToppCellImmune-T_lymphocyte|World / Lineage, Cell type, age group and donor

FNBP1 RNF125 DOCK10 ATM

3.05e-04194744f47fa18c87b35a3960557f8169ff7830dd6ecb80
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

TRPC3 SLC35D3 SNAI2 PCDH7

3.11e-04195744c5d2d9f12fd893331c9de261af30607d845d4f6a
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SNAI2 DOCK10 UNC13C PCDH7

3.11e-041957441cdf5f296029ae424d9dba42e86a6d111e4896e6
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

VWA3A HHLA2 CFAP70 CPLANE1

3.11e-0419574479dc031258579ea328181dda33710dd897f1064a
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRPC3 DOCK10 UNC13C PROX1

3.11e-0419574498ca9f3aa36211dde1e6f7f3817b9418c95e583e
ToppCellfacs-Bladder-nan-3m|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IBTK COPA PCDH7 RYK

3.17e-0419674444f5b1b474399c9316729155f2ea95a82ca66e30
ToppCellBasal_cells-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

TRPC6 SNAI2 SNX31 PCDH7

3.17e-041967443b66f3a79b3f2ebacb4ad646f179e505ab38d6f0
ToppCellCaecum-T_cell-Tfh|T_cell / Region, Cell class and subclass

GTF2IRD2B ACAD9 UNC13C ATM

3.17e-04196744fe2ee5788028e6b671674f0cc50e2b6379f50976
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SPATA6 SNAI2 UNC13C PCDH7

3.17e-041967441450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCellBronchial-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD56bright|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FNBP1 RNF125 KLRF2 DOCK10

3.17e-04196744bbdc92ec2e95ed7d782df0c72d94f9a9d9439bf0
ToppCellfacs-Bladder-nan-3m-Epithelial|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IBTK COPA PCDH7 RYK

3.17e-04196744c0e90d964baa2eb4fbd18a52379ccec5d3bf59a8
ToppCellPBMC-Control-cDC_3|Control / Compartment, Disease Groups and Clusters

FNBP1 COPA PI4KA TRPC6

3.17e-0419674409d197b321ff9f13c0672ea059c850845b0dbbd5
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SPATA6 DOCK10 UNC13C PCDH7

3.23e-0419774431a1852911bda38543916585fda34255fd62a134
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

VWA3A HHLA2 CFAP70 CPLANE1

3.23e-0419774474a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCellControl-PLT_4|Control / Disease Group and Platelet Clusters

CNNM2 ZNF148 TOP1 VPS13B

3.29e-04198744387fd3037fd52e4d4c42de0588767e58af228b59
ToppCellLPS_anti-TNF-Hematopoietic_Myeloid-Dendritic_cells|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

MSANTD1 KLRF2 DOCK10 PADI2

3.29e-04198744b2c8d5956f8449df4b69fb1b30632253440f815e
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TTC39B PHC3 ATM VPS13B

3.35e-04199744f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellPCW_10-12-Mesenchymal|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SPATA6 SNAI2 UNC13C PCDH7

3.35e-04199744a09292de4c4447b8eee55d401808e43b817321cc
ToppCellSevere-B_intermediate-6|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

FNBP1 ANXA4 ITSN2 DOCK10

3.35e-04199744bf6ebb63ab361d9d1946225894d7be433e9befab
ToppCellNeuronal-Inhibitory-iA-iA_2(LAMP5)-LCP2--L1-4|Neuronal / cells hierarchy compared to all cells using T-Statistic

TRPC3 DOCK10 UNC13C PROX1

3.42e-04200744f268cb1bb047e88913a828614b0a77871f5f8814
ToppCellNeuronal-Inhibitory-iA-iA_2(LAMP5)-LCP2|Neuronal / cells hierarchy compared to all cells using T-Statistic

TRPC3 DOCK10 UNC13C PROX1

3.42e-042007445ff9ac97ef970b3b74ebb07f62a0a1f4176a10b4
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Pericyte-Pericyte_2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

CNNM2 TRPC3 TRPC6 SNAI2

3.42e-04200744cf883ba5dbe6350b93142d625a52b25ff2a8bb63
ToppCellNeuronal-Inhibitory-iA-iA_2(LAMP5)|Neuronal / cells hierarchy compared to all cells using T-Statistic

TRPC3 DOCK10 UNC13C PROX1

3.42e-04200744e90155498397524b812c46f2412320230b445bb6
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

VPS13C ITSN2 ATM MX2

3.42e-0420074412f1685ce8f218433068e090c9d839cd5a1910bf
Diseasenicotine dependence (implicated_via_orthology)

TRPC7 TRPC3 TRPC6

3.15e-0612733DOID:0050742 (implicated_via_orthology)
DiseaseCohen syndrome (implicated_via_orthology)

VPS13C VPS13B

1.81e-053732DOID:0111590 (implicated_via_orthology)
DiseasePeripheral T-Cell Lymphoma

CD58 ATM

2.68e-0410732C0079774
Diseasecancer (implicated_via_orthology)

PHC3 ATM TOP1 PHC1 PROX1

5.41e-04268735DOID:162 (implicated_via_orthology)
DiseaseAutosomal recessive primary microcephaly

ZNF335 PHC1

6.21e-0415732cv:C3711387
Diseaseresponse to methotrexate

ZNF148 SLCO1B1

7.08e-0416732GO_0031427
Diseaseintellectual disability (implicated_via_orthology)

NAA15 ITSN2 RYK

8.63e-0475733DOID:1059 (implicated_via_orthology)
Diseaseleukemia (implicated_via_orthology)

ATM DOT1L

1.00e-0319732DOID:1240 (implicated_via_orthology)
Diseasebody weight

HHLA2 CNNM2 ZBTB38 RASGRF1 ADAMTS3 VPS13C INPP5B DOT1L PCDH7 DNAH14

1.05e-0312617310EFO_0004338
Diseasefeeling nervous measurement

AREL1 CNNM2 DNAH14

1.33e-0387733EFO_0009597
Diseasecortex volume change measurement, age at assessment

UNC13C TOP1

2.19e-0328732EFO_0008007, EFO_0021500

Protein segments in the cluster

PeptideGeneStartEntry
MTAEYACTRKQFNKR

ACAD9

321

Q9H845
MSASYQEAKCKLKSY

ADAD1

541

Q96M93
KSFESMQRLCDKYNR

DOT1L

66

Q8TEK3
KCMRNKSAYFAEKLY

ANXA4

241

P09525
LKYRQKFNTLDKSMS

ITSN2

246

Q9NZM3
KMKQTLIRSQFACTY

PARPBP

421

Q9NWS1
NMTFQYRKLKCMTDS

MSANTD1

101

Q6ZTZ1
TYSSKETCFSKKKLM

LEXM

71

Q3ZCV2
CKRNSTSIYFKMEND

CD58

166

P19256
EFAAMYSAKQLKLSC

IBTK

881

Q9P2D0
SKYMNFRVRACNKAV

FSD1L

271

Q9BXM9
KEMQNLSFQDCYSSK

ECHS1

101

P30084
EYSCQTNNKYSKQMR

PCDH7

1046

O60245
SCMSQNASLLKVYSK

KLRK1

126

P26718
MKYEKRNTNSFLICS

HHLA2

146

Q9UM44
CVKKDYSNFMASLNL

PI4KA

1131

P42356
MASTSACYKLFREKQ

PADI2

491

Q9Y2J8
KRFCTMSCAKRYNVS

PHC3

801

Q8NDX5
MSCAKRYNVSCSKKF

PHC3

806

Q8NDX5
DRFINSKCAKYMLKA

NAA15

441

Q9BXJ9
YKSELFQKAKSLMQC

ATM

741

Q13315
QYTKYGCRRKSDNKM

ADAMTS3

866

O15072
GYMTLSFKNRCKSKQ

KLRF2

6

D3W0D1
KSNRQFCSKLGKYRM

DOCK10

541

Q96BY6
MSCTVNVLNFYKEKK

DOCK5

1221

Q9H7D0
FCKRDSNFMRSKKKS

CPLANE1

1041

Q9H799
KYTSCKAFISNLNEM

FNBP1

66

Q96RU3
SKYQMSSFSNKEDRC

CCDC18

416

Q5T9S5
TQKMYELKTKLRCSY

DCST1

236

Q5T197
NSSMYRESCKGKLSK

G6PC1

276

P35575
YEKAKKTYMQACKRS

CFAP70

1016

Q5T0N1
EMCYQRTKNFDKLSF

COPA

691

P53621
IEDKRMYECKSQKFN

GALNT4

116

Q8N4A0
FYMLSMKNKACRKNL

LINC00305

71

Q7Z4B0
IFSKTSCSYCTMAKK

GLRX2

71

Q9NS18
YKSKVCFILNNDMSE

AREL1

606

O15033
IKSQIMFYNDCVKSF

DNAH14

1016

Q0VDD8
SLSKREFCFQNVKYM

INPP5B

671

P32019
LFSIMKLSKTKYCSQ

GTF2IRD2

921

Q86UP8
LFSIMKLSKTKYCSQ

GTF2IRD2B

921

Q6EKJ0
KNFTVLNFKRRKMCY

RYK

181

P34925
SYRKKQLDKSMCSQF

C4orf51

51

C9J302
NFPSSMYCDNRKLKT

OMD

71

Q99983
SLCKYFEDSRNMKTL

NXF2

436

Q9GZY0
IYCVAKFMETRKQSN

SLC35D3

296

Q5M8T2
SASSKVLKSMCENFY

SYNJ1

511

O43426
DFCSRYIACLKTKMN

PKNOX1

141

P55347
NMLKTYFSDVKFNRC

PROX1

601

Q92786
YQCKNCSKTFSRMSL

SNAI2

241

O43623
FSKTMNSCKVLQIRY

RASGRF1

636

Q13972
SENKKTRYCNGLKMF

SLCO1B1

16

Q9Y6L6
YTKQAFLLSSCLKKM

SNX31

361

Q8N9S9
NNKMFSNCSKQSIYK

ADAM17

446

P78536
RKMEKSKSYYLCTSL

CNNM2

181

Q9H8M5
NECEKAFSQKSYLML

ZNF182

461

P17025
MKDALQTCQKYRKKY

TTC39B

196

Q5VTQ0
ATDVAKRMKSEYKNC

RNF125

86

Q96EQ8
SFKEAALRAYKKQMA

UNC13C

971

Q8NB66
FKEKTKCMINQYSNY

PHEX

611

P78562
KAYLKKISMQCFDFT

VPS13C

1471

Q709C8
KRFCSMTCAKRYNVS

PHC1

816

P78364
YSCMALSKSKSQEQK

VPS13B

1851

Q7Z7G8
TTQSKIFQCDKYMKI

ZNF681

136

Q96N22
KAFKCQYCMKSFSTS

ZNF236

536

Q9UL36
MKCKRAPYKSYRNSS

ZBTB38

571

Q8NAP3
STNYDDAMQFLKKKR

ZNF148

461

Q9UQR1
NDYKKLSMQCKDFVV

TRPC6

316

Q9Y210
KCKMCQYRSSTKATL

ZNF335

246

Q9H4Z2
NLSKCDFTQMSQYFK

TOP1

296

P11387
MDKMYRNLYKKACSS

SPATA6

466

Q9NWH7
KALNYSQKCAFLMAS

VWA3A

706

A6NCI4
KEFKNDYRKLSMQCK

TRPC3

241

Q13507
ETEFKNDYRKLSMQC

TRPC7

256

Q9HCX4
KNSSACKDYLIEAMK

KLHL2

266

O95198
FSSRKYLKKEMNSFQ

MX2

16

P20592
KENYEKTKAKSMNYC

NEB

636

P20929