Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	GRB2 RGPD8 RASA3 MYCBP2 SIPA1L1 RGPD5 THG1L	4.16e-05	507	38	7	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	GRB2 RGPD8 RASA3 MYCBP2 SIPA1L1 RGPD5 THG1L	4.16e-05	507	38	7	GO:0030695
GeneOntologyMolecularFunction	protein phosphatase binding	GRB2 HSP90B1 HSP90B2P AP3B1 ITPR1	4.64e-05	210	38	5	GO:0019903
GeneOntologyMolecularFunction	phosphatase binding	GRB2 HSP90B1 HSP90B2P AP3B1 ITPR1	1.37e-04	264	38	5	GO:0019902
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	RASA3 ITPR1	5.29e-04	18	38	2	GO:0015278
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	RASA3 ITPR1	1.58e-03	31	38	2	GO:0099604
GeneOntologyMolecularFunction	ephrin receptor binding	GRB2 SIPA1L1	1.69e-03	32	38	2	GO:0046875
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	RASA3 ITPR1	1.79e-03	33	38	2	GO:0005217
GeneOntologyMolecularFunction	calcium channel activity	CACNA1A RASA3 ITPR1	1.88e-03	129	38	3	GO:0005262
GeneOntologyMolecularFunction	GTPase activator activity	RGPD8 RASA3 SIPA1L1 RGPD5	1.89e-03	279	38	4	GO:0005096
GeneOntologyMolecularFunction	low-density lipoprotein particle receptor binding	HSP90B1 HSP90B2P	1.90e-03	34	38	2	GO:0050750
GeneOntologyMolecularFunction	lipoprotein particle receptor binding	HSP90B1 HSP90B2P	2.50e-03	39	38	2	GO:0070325
GeneOntologyMolecularFunction	ATP-dependent protein folding chaperone	HSP90B1 HSP90B2P	2.63e-03	40	38	2	GO:0140662
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNA1A RASA3 ITPR1	2.95e-03	151	38	3	GO:0015085
GeneOntologyMolecularFunction	peptidyl-prolyl cis-trans isomerase activity	RGPD8 FKBP4	4.08e-03	50	38	2	GO:0003755
GeneOntologyMolecularFunction	enzyme regulator activity	GRB2 HRG RGPD8 RASA3 MYCBP2 SIPA1L1 RGPD5 THG1L	4.55e-03	1418	38	8	GO:0030234
GeneOntologyMolecularFunction	cis-trans isomerase activity	RGPD8 FKBP4	4.57e-03	53	38	2	GO:0016859
GeneOntologyMolecularFunction	isomerase activity	RGPD8 FKBP4 PUS7L	5.77e-03	192	38	3	GO:0016853
GeneOntologyMolecularFunction	ATP-dependent activity	SHOC1 HSP90B1 CHD2 HSP90B2P MYO7A	5.87e-03	614	38	5	GO:0140657
GeneOntologyBiologicalProcess	multicellular organismal movement	DIAPH2 CACNA1A CASQ1 ITPR1	9.73e-06	73	38	4	GO:0050879
GeneOntologyBiologicalProcess	actin rod assembly	HSP90B1 HSP90B2P	9.90e-06	3	38	2	GO:0031247
GeneOntologyBiologicalProcess	regulation of plasma membrane bounded cell projection organization	DIAPH2 CACNA1A HRG MYCBP2 UBE3A DYNC2LI1 FKBP4 SIPA1L1 ITPR1	1.76e-05	846	38	9	GO:0120035
GeneOntologyBiologicalProcess	regulation of cell projection organization	DIAPH2 CACNA1A HRG MYCBP2 UBE3A DYNC2LI1 FKBP4 SIPA1L1 ITPR1	2.06e-05	863	38	9	GO:0031344
GeneOntologyBiologicalProcess	neuromuscular process	CACNA1A CASQ1 MYCBP2 MYO7A ITPR1	5.53e-05	225	38	5	GO:0050905
GeneOntologyBiologicalProcess	actin cytoskeleton organization	DIAPH2 GRB2 HRG CASQ1 HSP90B1 HSP90B2P MYO7A SIPA1L1	8.82e-05	803	38	8	GO:0030036
GeneOntologyBiologicalProcess	intracellular monoatomic cation homeostasis	CACNA1A CASQ1 HSP90B1 AP3B1 UBE3A FBXL5 ITPR1	1.10e-04	611	38	7	GO:0030003
GeneOntologyBiologicalProcess	regulation of neuron projection development	DIAPH2 CACNA1A MYCBP2 UBE3A FKBP4 SIPA1L1 ITPR1	1.11e-04	612	38	7	GO:0010975
GeneOntologyBiologicalProcess	intracellular monoatomic ion homeostasis	CACNA1A CASQ1 HSP90B1 AP3B1 UBE3A FBXL5 ITPR1	1.23e-04	622	38	7	GO:0006873
GeneOntologyBiologicalProcess	actin filament-based process	DIAPH2 GRB2 HRG CASQ1 HSP90B1 HSP90B2P MYO7A SIPA1L1	2.12e-04	912	38	8	GO:0030029
GeneOntologyBiologicalProcess	insulin processing	HSP90B1 HSP90B2P	2.16e-04	12	38	2	GO:0030070
GeneOntologyBiologicalProcess	monoatomic cation homeostasis	CACNA1A CASQ1 HSP90B1 AP3B1 UBE3A FBXL5 ITPR1	2.65e-04	705	38	7	GO:0055080
GeneOntologyBiologicalProcess	musculoskeletal movement	CACNA1A CASQ1 ITPR1	2.78e-04	69	38	3	GO:0050881
GeneOntologyBiologicalProcess	monoatomic ion homeostasis	CACNA1A CASQ1 HSP90B1 AP3B1 UBE3A FBXL5 ITPR1	2.93e-04	717	38	7	GO:0050801
GeneOntologyBiologicalProcess	supramolecular fiber organization	DIAPH2 GRB2 BMP1 CASQ1 HSP90B1 HSP90B2P MYO7A FKBP4	2.95e-04	957	38	8	GO:0097435
GeneOntologyBiologicalProcess	regulation of sulfur metabolic process	CACNA1A PDK1	4.42e-04	17	38	2	GO:0042762
GeneOntologyCellularComponent	smooth endoplasmic reticulum	CASQ1 HSP90B1 HSP90B2P ITPR1	1.43e-06	46	38	4	GO:0005790
GeneOntologyCellularComponent	sarcoplasmic reticulum	CASQ1 HSP90B1 HSP90B2P ITPR1	1.94e-05	88	38	4	GO:0016529
GeneOntologyCellularComponent	sarcoplasm	CASQ1 HSP90B1 HSP90B2P ITPR1	5.37e-05	114	38	4	GO:0016528
GeneOntologyCellularComponent	sarcoplasmic reticulum lumen	CASQ1 HSP90B1	1.15e-04	9	38	2	GO:0033018
GeneOntologyCellularComponent	endoplasmic reticulum chaperone complex	HSP90B1 HSP90B2P	2.48e-04	13	38	2	GO:0034663
GeneOntologyCellularComponent	sperm plasma membrane	HSP90B1 HSP90B2P	7.26e-04	22	38	2	GO:0097524
HumanPheno	Gaze-evoked horizontal nystagmus	CACNA1A ITPR1 THG1L	2.02e-05	18	16	3	HP:0007979
Domain	Grip	RGPD8 RGPD5	1.97e-04	11	36	2	SM00755
Domain	GRIP	RGPD8 RGPD5	1.97e-04	11	36	2	PF01465
Domain	Ran_BP1	RGPD8 RGPD5	2.36e-04	12	36	2	PF00638
Domain	GRIP_dom	RGPD8 RGPD5	2.36e-04	12	36	2	IPR000237
Domain	GRIP	RGPD8 RGPD5	2.36e-04	12	36	2	PS50913
Domain	RANBD1	RGPD8 RGPD5	2.36e-04	12	36	2	PS50196
Domain	RanBD	RGPD8 RGPD5	2.78e-04	13	36	2	SM00160
Domain	Ran_bind_dom	RGPD8 RGPD5	2.78e-04	13	36	2	IPR000156
Domain	HATPase_c	HSP90B1 PDK1	5.42e-04	18	36	2	SM00387
Domain	HATPase_c	HSP90B1 PDK1	6.05e-04	19	36	2	PF02518
Domain	-	HSP90B1 PDK1	6.72e-04	20	36	2	3.30.565.10
Domain	TPR_1	RGPD8 FKBP4 RGPD5	6.89e-04	90	36	3	PF00515
Domain	TPR_1	RGPD8 FKBP4 RGPD5	6.89e-04	90	36	3	IPR001440
Domain	HATPase_C	HSP90B1 PDK1	7.41e-04	21	36	2	IPR003594
Domain	ZnMc	BMP1 MMP10	1.42e-03	29	36	2	SM00235
Domain	Peptidase_Metallo	BMP1 MMP10	1.42e-03	29	36	2	IPR006026
Domain	TPR-contain_dom	RGPD8 FKBP4 RGPD5	2.99e-03	150	36	3	IPR013026
Domain	Growth_fac_rcpt_	ATRN BMP1 BRINP3	3.33e-03	156	36	3	IPR009030
Domain	TPR_REGION	RGPD8 FKBP4 RGPD5	3.90e-03	165	36	3	PS50293
Domain	TPR	RGPD8 FKBP4 RGPD5	3.90e-03	165	36	3	PS50005
Domain	CUB	ATRN BMP1	4.01e-03	49	36	2	PF00431
Domain	CUB	ATRN BMP1	4.18e-03	50	36	2	SM00042
Domain	-	ATRN BMP1	4.51e-03	52	36	2	2.60.120.290
Domain	CUB	ATRN BMP1	4.68e-03	53	36	2	PS01180
Domain	CUB_dom	ATRN BMP1	5.39e-03	57	36	2	IPR000859
Domain	SH3_domain	GRB2 MIA2 MYO7A	8.65e-03	220	36	3	IPR001452
Domain	PH_dom-like	RGPD8 RASA3 MYO7A RGPD5	8.83e-03	426	36	4	IPR011993
Pathway	WP_PKCGAMMA_CALCIUM_SIGNALING_IN_ATAXIA	CACNA1A PDK1 ITPR1	1.30e-05	22	30	3	M39795
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	CACNA1A RTN3 HSP90B1 HSP90B2P RGPD8 MYCBP2 UBE3A PDK1 SIPA1L1 ITPR1	2.80e-07	1139	38	10	36417873
Pubmed	Pigmentation-related genes and their implication in malignant melanoma susceptibility.	ATRN AP3B1 MYO7A	4.34e-07	14	38	3	19320733
Pubmed	Deletion of muscle GRP94 impairs both muscle and body growth by inhibiting local IGF production.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	22649033
Pubmed	gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	19965672
Pubmed	Essential role of the molecular chaperone gp96 in regulating melanogenesis.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	24024552
Pubmed	Evidence that glycoprotein 96 (B2), a stress protein, functions as a Th2-specific costimulatory molecule.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	12244140
Pubmed	Glucose-regulated protein 94/glycoprotein 96 elicits bystander activation of CD4+ T cell Th1 cytokine production in vivo.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	15034032
Pubmed	Glucose-regulated protein (GRP94 and GRP78) genes share common regulatory domains and are coordinately regulated by common trans-acting factors.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	2546060
Pubmed	Cross-presentation of glycoprotein 96-associated antigens on major histocompatibility complex class I molecules requires receptor-mediated endocytosis.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	10839811
Pubmed	The endoplasmic reticulum chaperone BiP is a closure-accelerating cochaperone of Grp94.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	35078937
Pubmed	The molecular chaperone gp96/GRP94 interacts with Toll-like receptors and integrins via its C-terminal hydrophobic domain.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	22223641
Pubmed	Down-regulation of gp96 by Orientia tsutsugamushi.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	15107540
Pubmed	Induction of regulatory T cells by high-dose gp96 suppresses murine liver immune hyperactivation.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	23874845
Pubmed	GRP94/gp96 elicits ERK activation in murine macrophages. A role for endotoxin contamination in NF-kappa B activation and nitric oxide production.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	12805368
Pubmed	Mapping of the genes for human endoplasmic reticular heat shock protein gp96/grp94.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	8460400
Pubmed	Chromosomal assignment of the gene encoding the mouse tumor rejection antigen gp96.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	3410508
Pubmed	An essential role for ATP binding and hydrolysis in the chaperone activity of GRP94 in cells.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	19553200
Pubmed	Oocyte-targeted deletion reveals that hsp90b1 is needed for the completion of first mitosis in mouse zygotes.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	21358806
Pubmed	Glycoprotein (GP)96 Is Essential for Maintaining Intestinal Epithelial Architecture by Supporting Its Self-Renewal Capacity.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	36516930
Pubmed	Radicicol-sensitive peptide binding to the N-terminal portion of GRP94.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	12189140
Pubmed	Amino acid copolymers that alleviate experimental autoimmune encephalomyelitis in vivo interact with heparan sulfates and glycoprotein 96 in APCs.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	23740953
Pubmed	GP96 Drives Exacerbation of Secondary Bacterial Pneumonia following Influenza A Virus Infection.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	34061598
Pubmed	Phylogenetic conservation of the molecular and immunological properties of the chaperones gp96 and hsp70.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	11265634
Pubmed	Glucose regulated protein 94 is required for muscle differentiation through its control of the autocrine production of insulin-like growth factors.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	19914304
Pubmed	HSP90β promotes osteoclastogenesis by dual-activation of cholesterol synthesis and NF-κB signaling.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	36198833
Pubmed	gp96 expression in neutrophils is critical for the onset of Escherichia coli K1 (RS218) meningitis.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	22109526
Pubmed	Deficiency of GRP94 in the hematopoietic system alters proliferation regulators in hematopoietic stem cells.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	23859598
Pubmed	Glycoprotein 96 can chaperone both MHC class I- and class II-restricted epitopes for in vivo presentation, but selectively primes CD8+ T cell effector function.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	15128793
Pubmed	HSP100, a 100-kDa heat shock protein, is a Ca2+-calmodulin-regulated actin-binding protein.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	2768254
Pubmed	Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10.	ZNF267 MMP10	1.16e-06	2	38	2	16054593
Pubmed	GRP94 promotes muscle differentiation by inhibiting the PI3K/AKT/mTOR signaling pathway.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	31025379
Pubmed	The endoplasmic reticulum chaperone protein GRP94 is required for maintaining hematopoietic stem cell interactions with the adult bone marrow niche.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	21647226
Pubmed	Chaperone gp96 mediates ER-α36 cell membrane expression.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	26396174
Pubmed	Type 2 dendritic cells mediate control of cytotoxic T cell resistant tumors.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	34283809
Pubmed	The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation.	UBE3A SIPA1L1	1.16e-06	2	38	2	9858596
Pubmed	Isolation and identification of partial cDNA clones for endoplasmin, the major glycoprotein of mammalian endoplasmic reticulum.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	3612811
Pubmed	Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is Essential for Proinsulin Handling.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	30670477
Pubmed	Chaperone gp96-independent inhibition of endotoxin response by chaperone-based peptide inhibitors.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	22532561
Pubmed	The peptide-binding activity of GRP94 is regulated by calcium.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	17411420
Pubmed	gp96 is a human colonocyte plasma membrane binding protein for Clostridium difficile toxin A.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	18411291
Pubmed	Targeted deletion of ER chaperone GRP94 in the liver results in injury, repopulation of GRP94-positive hepatocytes, and spontaneous hepatocellular carcinoma development in aged mice.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	25220589
Pubmed	Cell surface targeting of heat shock protein gp96 induces dendritic cell maturation and antitumor immunity.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	11739487
Pubmed	5'-structural analysis of genes encoding polymorphic antigens of chemically induced tumors.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	2438686
Pubmed	Cutting Edge: Targeting Thrombocytes to Rewire Anticancer Immunity in the Tumor Microenvironment and Potentiate Efficacy of PD-1 Blockade.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	31358658
Pubmed	Decreased adhesiveness, resistance to anoikis and suppression of GRP94 are integral to the survival of circulating tumor cells in prostate cancer.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	18340425
Pubmed	Interaction of Toll-Like Receptors with the Molecular Chaperone Gp96 Is Essential for Its Activation of Cytotoxic T Lymphocyte Response.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	27183126
Pubmed	Combination of direct intratumoral administration of dendritic cells and irradiation induces strong systemic antitumor effect mediated by GRP94/gp96 against squamous cell carcinoma in mice.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	17671676
Pubmed	Treg suppress CTL responses upon immunization with HSP gp96.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	19839010
Pubmed	The heat shock protein Gp96 binds to human neutrophils and monocytes and stimulates effector functions.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	12446445
Pubmed	GRP94 Is Involved in the Lipid Phenotype of Brain Metastatic Cells.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	31395819
Pubmed	Immunolocalization and heart levels of GRP94 in the mouse during post-implantation development.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	9363855
Pubmed	Regulation of dendritic cell function improves survival in experimental sepsis through immune chaperone.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	31018807
Pubmed	Hsp90β1 knockout targeted to male germline: a mouse model for globozoospermia.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	21208614
Pubmed	Limitation of individual folding resources in the ER leads to outcomes distinct from the unfolded protein response.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	22854046
Pubmed	Identification of gp96 as a novel target for treatment of autoimmune disease in mice.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	20352117
Pubmed	GRP94 (gp96) and GRP94 N-terminal geldanamycin binding domain elicit tissue nonrestricted tumor suppression.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	12461080
Pubmed	Heat-Shock Protein gp96 Enhances T Cell Responses and Protective Potential to Bacillus Calmette-Guérin Vaccine.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	27417661
Pubmed	Proteomic plasma membrane profiling reveals an essential role for gp96 in the cell surface expression of LDLR family members, including the LDL receptor and LRP6.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	22292497
Pubmed	Gp96 deficiency affects TLR4 functionality and impairs ERK and p38 phosphorylation.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	29447283
Pubmed	Analysis of the structure and synthesis of GRP94, an abundant stress protein of the endoplasmic reticulum.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	8179819
Pubmed	Visualization of conformational transition of GRP94 in solution.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	37949474
Pubmed	Endoplasmic reticulum resident heat shock protein-gp96 as morphogenetic and immunoregulatory factor in syngeneic pregnancy.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	23553495
Pubmed	Bap, a biofilm matrix protein of Staphylococcus aureus prevents cellular internalization through binding to GP96 host receptor.	HSP90B1 HSP90B2P	1.16e-06	2	38	2	22876182
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	CACNA1A GRB2 RTN3 HRG HSP90B1 HSP90B2P AP3B1 MYO7A PDK1 SIPA1L1	2.22e-06	1431	38	10	37142655
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	ANKRD11 GRB2 RTN3 HSP90B1 AP3B1 MYCBP2 PDK1 NSRP1 FKBP4 ITPR1	3.13e-06	1487	38	10	33957083
Pubmed	Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	23572575
Pubmed	Tyrosine phosphorylation activates surface chaperones facilitating sperm-zona recognition.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	15252132
Pubmed	Calcium-binding protein 1 is an inhibitor of agonist-evoked, inositol 1,4,5-trisphosphate-mediated calcium signaling.	CACNA1A ITPR1	3.48e-06	3	38	2	14570872
Pubmed	Re-examination of CD91 function in GRP94 (glycoprotein 96) surface binding, uptake, and peptide cross-presentation.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	21048103
Pubmed	Murine but not human basophil undergoes cell-specific proteolysis of a major endoplasmic reticulum chaperone.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	22724016
Pubmed	Grp94 is Tyr-phosphorylated by Fyn in the lumen of the endoplasmic reticulum and translocates to Golgi in differentiating myoblasts.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	19000718
Pubmed	Expression of the glucose-regulated proteins (GRP94 and GRP78) in differentiated and undifferentiated mouse embryonic cells and the use of the GRP78 promoter as an expression system in embryonic cells.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	1692794
Pubmed	Ovalbumin-derived precursor peptides are transferred sequentially from gp96 and calreticulin to MHC class I in the endoplasmic reticulum.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	20410492
Pubmed	The chaperone activity of GRP94 toward insulin-like growth factor II is necessary for the stress response to serum deprivation.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	19158397
Pubmed	Heat shock proteins gp96 and hsp70 activate the release of nitric oxide by APCs.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	11884472
Pubmed	GP96 is a GARP chaperone and controls regulatory T cell functions.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	25607841
Pubmed	The endoplasmic reticulum (ER) chaperones BiP and Grp94 selectively associate when BiP is in the ADP conformation.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	30787103
Pubmed	Aminoacyl-tRNA synthetase-interacting multifunctional protein 1/p43 controls endoplasmic reticulum retention of heat shock protein gp96: its pathological implications in lupus-like autoimmune diseases.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	17525271
Pubmed	Cell surface expression of an endoplasmic reticulum resident heat shock protein gp96 triggers MyD88-dependent systemic autoimmune diseases.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	14668429
Pubmed	Endoplasmic reticulum HSP90b1 (gp96, grp94) optimizes B-cell function via chaperoning integrin and TLR but not immunoglobulin.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	18509083
Pubmed	Immune chaperone gp96 drives the contributions of macrophages to inflammatory colon tumorigenesis.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	24322981
Pubmed	ERp99, an abundant, conserved glycoprotein of the endoplasmic reticulum, is homologous to the 90-kDa heat shock protein (hsp90) and the 94-kDa glucose regulated protein (GRP94).	HSP90B1 HSP90B2P	3.48e-06	3	38	2	3036833
Pubmed	Liver-specific knockout of GRP94 in mice disrupts cell adhesion, activates liver progenitor cells, and accelerates liver tumorigenesis.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	24027047
Pubmed	Heat shock protein gp96 regulates Toll-like receptor 9 proteolytic processing and conformational stability.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	22554506
Pubmed	Differential requirement of GRP94 and GRP78 in mammary gland development.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	24953136
Pubmed	GRP94 is an IGF-1R chaperone and regulates beta cell death in diabetes.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	38811543
Pubmed	Endoplasmic reticulum chaperone gp96 in macrophages is essential for protective immunity during Gram-negative pneumonia.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	26365983
Pubmed	Deletion of CD24 impairs development of heat shock protein gp96-driven autoimmune disease through expansion of myeloid-derived suppressor cells.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	24808359
Pubmed	Heat-shock protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V complex.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	21576699
Pubmed	Estrogenic regulation of murine uterine 90-kilodalton heat shock protein gene expression.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	2796999
Pubmed	GRP94 regulates M1 macrophage polarization and insulin resistance.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	32208002
Pubmed	Gut homeostasis and regulatory T cell induction depend on molecular chaperone gp96 in CD11c+ cells.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	28526855
Pubmed	Sex-Related Differences in Murine Models of Chemically Induced Pulmonary Fibrosis.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	34072833
Pubmed	The GRP94 Inhibitor PU-WS13 Decreases M2-like Macrophages in Murine TNBC Tumors: A Pharmaco-Imaging Study with 99mTc-Tilmanocept SPECT.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	34943901
Pubmed	Valproate, a mood stabilizer, induces WFS1 expression and modulates its interaction with ER stress protein GRP94.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	19125190
Pubmed	Essential roles of IL-12 and dendritic cells but not IL-23 and macrophages in lupus-like diseases initiated by cell surface HSP gp96.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	17294405
Pubmed	Endoplasmic reticulum stress gene induction and protection from ischemia/reperfusion injury in the hearts of transgenic mice with a tamoxifen-regulated form of ATF6.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	16601230
Pubmed	Stimulation of CK2-dependent Grp94 phosphorylation by the nuclear localization signal peptide.	HSP90B1 HSP90B2P	3.48e-06	3	38	2	21739154
Pubmed	Endoplasmic reticulum resident protein 44 (ERp44) deficiency in mice and zebrafish leads to cardiac developmental and functional defects.	HSP90B1 HSP90B2P ITPR1	3.87e-06	28	38	3	25332179
Pubmed	Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155.	HSP90B1 HSP90B2P	6.96e-06	4	38	2	23572582
Interaction	RGPD8 interactions	MIA2 RGPD8 MYCBP2 RGPD5	1.12e-05	74	38	4	int:RGPD8
Interaction	TTC23L interactions	ANKRD11 MIA2 UBE3A	1.56e-05	26	38	3	int:TTC23L
Interaction	GCNA interactions	HSP90B1 HSP90B2P	3.45e-05	5	38	2	int:GCNA
Interaction	CCDC74A interactions	RGPD8 UBE3A RGPD5	3.88e-05	35	38	3	int:CCDC74A
Interaction	SPRY1 interactions	ANKRD11 CACNA1A GRB2 HRG	5.57e-05	111	38	4	int:SPRY1
Interaction	MIA2 interactions	GRB2 MIA2 RGPD8 RGPD5	5.97e-05	113	38	4	int:MIA2
Interaction	ECI2 interactions	HSP90B1 UBE3A PDK1 FBXL5	6.61e-05	116	38	4	int:ECI2
Interaction	RGPD3 interactions	MIA2 RGPD8 RGPD5	9.47e-05	47	38	3	int:RGPD3
Cytoband	2q13	RGPD8 RGPD5	1.47e-03	68	38	2	2q13
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	RGPD8 FKBP4 RGPD5	4.60e-04	115	24	3	769
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF267 SALL1 ZNF234 ZNF639	1.39e-02	718	24	4	28
Coexpression	GSE2770_IL12_ACT_VS_ACT_CD4_TCELL_48H_UP	RTN3 HSP90B1 CHD2 MIA2 RASA3	8.79e-06	200	37	5	M6032
Coexpression	NAKAYA_PBMC_FLUARIX_FLUVIRIN_AGE_18_50YO_3DY_DN	ANKRD11 CHD2 RGPD8 ZNF639 ITPR1 RGPD5	2.92e-05	432	37	6	M41149
Coexpression	HAMAI_APOPTOSIS_VIA_TRAIL_UP	HSP90B1 AP3B1 MYCBP2 UBE3A NSRP1 PUS7L ITPR1	3.19e-05	656	37	7	M18979
Coexpression	NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN	DIAPH2 ANKRD11 MYO7A UBE3A FKBP4	5.57e-05	294	37	5	M41112
Coexpression	GSE38696_LIGHT_ZONE_VS_DARK_ZONE_BCELL_UP	CHD2 RASA3 MYCBP2 PDK1	1.30e-04	184	37	4	M9005
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	ATRN MIA2 AP3B1 MYCBP2 UBE3A SIPA1L1 ITPR1	1.69e-04	856	37	7	M4500
Coexpression	GSE37416_0H_VS_6H_F_TULARENSIS_LVS_NEUTROPHIL_DN	ZNF267 CHD2 PDK1 SIPA1L1	1.72e-04	198	37	4	M5346
Coexpression	GSE1791_CTRL_VS_NEUROMEDINU_IN_T_CELL_LINE_6H_DN	CHD2 UBE3A PDK1 FBXL5	1.75e-04	199	37	4	M6172
Coexpression	GSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP	MIA2 DYNC2LI1 SIPA1L1 ITPR1	1.75e-04	199	37	4	M5694
Coexpression	GSE41867_LCMV_ARMSTRONG_VS_CLONE13_DAY6_EFFECTOR_CD8_TCELL_DN	CACNA1A MYCBP2 FKBP4 PUS7L	1.78e-04	200	37	4	M9477
Coexpression	GSE3720_VD1_VS_VD2_GAMMADELTA_TCELL_WITH_PMA_STIM_UP	AP3B1 MYO7A PDK1 NSRP1	1.78e-04	200	37	4	M6356
Coexpression	GSE40273_GATA1_KO_VS_WT_TREG_DN	ANKRD11 CHD2 ZNF639 ITPR1	1.78e-04	200	37	4	M9133
Coexpression	GSE19888_ADENOSINE_A3R_INH_PRETREAT_AND_ACT_BY_A3R_VS_A3R_INH_AND_TCELL_MEMBRANES_ACT_MAST_CELL_DN	ANKRD11 AP3B1 MYO7A PDK1	1.78e-04	200	37	4	M7353
Coexpression	GSE7460_TCONV_VS_TREG_LN_UP	MIA2 RASA3 PDK1 PUS7L	1.78e-04	200	37	4	M5673
Coexpression	GSE30971_CTRL_VS_LPS_STIM_MACROPHAGE_WBP7_HET_4H_UP	BMP1 CHD2 AP3B1 SIPA1L1	1.78e-04	200	37	4	M8705
Coexpression	GSE20366_EX_VIVO_VS_HOMEOSTATIC_CONVERSION_NAIVE_CD4_TCELL_UP	ANKRD11 CHD2 MYCBP2 PDK1	1.78e-04	200	37	4	M4323
Coexpression	YOSHIMURA_MAPK8_TARGETS_DN	CACNA1A MYCBP2 PDK1 SIPA1L1 ITPR1	1.83e-04	379	37	5	M1885
Coexpression	TABULA_MURIS_SENIS_MARROW_MATURE_ALPHA_BETA_T_CELL_AGEING	GRB2 HSP90B1 HSP90B2P MYCBP2 SIPA1L1 ITPR1	1.98e-04	612	37	6	MM3804
ToppCell	5'-Adult-SmallIntestine-Epithelial-neuro-epithelial-EECs\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1A BRINP3 MMP10 TPH1	1.09e-05	162	38	4	478cf560ef33c5c324142c76417447d4a571a2c9
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DIAPH2 ANKRD11 RGPD8 SIPA1L1	2.16e-05	193	38	4	779276e775cb2492e8dd36436295a536084a6415
ToppCell	Bronchus_Control_(B.)\|World / Sample group, Lineage and Cell type	SHOC1 ZNF267 MMP10 SIPA1L1	2.34e-05	197	38	4	b6dff2ee108813e18657e2d8cf850e2423f8c8e9
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1A RTN3 UBE3A ITPR1	2.39e-05	198	38	4	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	CACNA1A RTN3 MYCBP2 UBE3A	2.48e-05	200	38	4	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Intermediate\|3m / Sample Type, Dataset, Time_group, and Cell type.	ANKRD11 MYCBP2 PDK1 PUS7L	2.48e-05	200	38	4	cbd0b9188a94778ffa539912aeb2a4378f0ab88f
ToppCell	facs-Brain_Non-Myeloid-Hippocampus\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKRD11 ATRN RTN3 RASA3	2.48e-05	200	38	4	fc28f71ca1cd0fdae66009ae5afe175d22f2bd8c
ToppCell	COVID-19\|World / Disease, condition lineage and cell class	ANKRD11 GRB2 HSP90B1 MYCBP2	2.48e-05	200	38	4	7dec470c379cd89f05a0f37c8628b21f136e52f0
Drug	o463	SALL1 TPH1	8.13e-06	3	38	2	CID000075311
Drug	PNU-0251126 [267429-19-6]; Up 200; 10uM; MCF7; HT_HG-U133A	DIAPH2 CACNA1A BMP1 HSP90B1 UBE3A	1.62e-05	192	38	5	4711_UP
Drug	Lactobionic acid [96-82-2]; Up 200; 11.2uM; MCF7; HT_HG-U133A	MIA2 AP3B1 DYNC2LI1 SIPA1L1 ITPR1	1.75e-05	195	38	5	3246_UP
Drug	Alfaxalone [23930-19-0]; Down 200; 12uM; HL60; HT_HG-U133A	DIAPH2 ATRN BMP1 RASA3 SIPA1L1	1.75e-05	195	38	5	3135_DN
Drug	Gemfibrozil [25812-30-0]; Down 200; 16uM; PC3; HT_HG-U133A	ANKRD11 HSP90B1 AP3B1 UBE3A ITPR1	1.79e-05	196	38	5	2113_DN
Drug	Bezafibrate [41859-67-0]; Down 200; 11uM; MCF7; HT_HG-U133A	BMP1 UBE3A DYNC2LI1 PDK1 SIPA1L1	1.79e-05	196	38	5	2630_DN
Drug	Methylhydantoin-5-(D) [55147-68-7]; Down 200; 35uM; HL60; HT_HG-U133A	DIAPH2 CACNA1A BMP1 DYNC2LI1 SIPA1L1	1.83e-05	197	38	5	2994_DN
Drug	Picotamide monohydrate [80530-63-8]; Down 200; 10.2uM; MCF7; HT_HG-U133A	CACNA1A BMP1 MIA2 MYO7A SIPA1L1	1.83e-05	197	38	5	2233_DN
Drug	6-Furfurylaminopurine [525-79-1]; Up 200; 18.6uM; MCF7; HT_HG-U133A	BMP1 MYO7A UBE3A ZNF639 ITPR1	1.88e-05	198	38	5	6073_UP
Drug	estradiol, USP; Up 200; 0.01uM; ssMCF7; HG-U133A	CACNA1A BMP1 UBE3A PUS7L FBXL5	1.93e-05	199	38	5	373_UP
Drug	C mu	DIAPH2 FKBP4	4.05e-05	6	38	2	CID000008800
Disease	male infertility due to globozoospermia (implicated_via_orthology)	HSP90B1 HSP90B2P	1.37e-06	2	35	2	DOID:0112312 (implicated_via_orthology)
Disease	Epilepsy, Cryptogenic	ANKRD11 CHD2 UBE3A	1.27e-04	82	35	3	C0086237
Disease	Awakening Epilepsy	ANKRD11 CHD2 UBE3A	1.27e-04	82	35	3	C0751111
Disease	Aura	ANKRD11 CHD2 UBE3A	1.27e-04	82	35	3	C0236018
Disease	Neurodevelopmental Disorders	ANKRD11 CHD2 ITPR1	1.84e-04	93	35	3	C1535926
Disease	Bipolar Disorder	CACNA1A HSP90B1 MMP10 ITPR1 TPH1	2.35e-04	477	35	5	C0005586
Disease	Epilepsy	ANKRD11 CHD2 UBE3A	2.94e-04	109	35	3	C0014544
Disease	Epileptic encephalopathy	CACNA1A CHD2	5.82e-04	30	35	2	C0543888
Disease	autism spectrum disorder (implicated_via_orthology)	CHD2 UBE3A TPH1	7.77e-04	152	35	3	DOID:0060041 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
KFFHCTDESKEFEKD	CACNA1A	1401	O00555
KAYNSDFEESDEFKL	BRINP3	311	Q76B58
SFTYEYEDSKQKSDK	ANKRD11	656	Q6UB99
KAAEFSKKFDEEFTA	DIAPH2	496	O60879
FKAHFFSDKDECSKD	BMP1	696	P13497
SAKKFYSESEEEEDS	AP3B1	671	O00203
EFDDKEAFVTSAYKK	NSRP1	136	Q9H0G5
CSYSKKSHFDFEEED	RASA3	206	Q14644
TSGDFEKDDDAYKTE	RGPD5	1016	Q99666
TSGDFEKDDDAYKTE	RGPD8	1016	O14715
DKSAEDAKAIYDFTD	PDK1	126	Q15118
VSDKEKKKTYFFAAD	MMP10	391	P09238
EYKAFCKSFSKESDD	HSP90B2P	11	Q58FF3
ALEKYKEENDDFASF	HRG	161	P04196
TEDKKSEKFFKVFYD	ITPR1	1856	Q14643
IKEYKDSFSNEKFDF	ATRN	1231	O75882
SKYDVFQDFESEKRK	DYNC2LI1	186	Q8TCX1
KYDFKATADDELSFK	GRB2	6	P62993
EEDEYKAFYKSFSKE	HSP90B1	351	P14625
AAKNVSYKEDDDFET	CHD2	226	O14647
FKSKDSEHYKAFEDA	CASQ1	186	P31415
QKFFKYSVDEKSDKE	FBXL5	181	Q9UKA1
KFDSSLDRKDKFSFD	FKBP4	66	Q02790
FEAKSTSDEAFFKHK	SALL1	436	Q9NSC2
EDKDEKSSIYESDFQ	MIA2	146	Q96PC5
IIDKAAFDKEFKDSY	RTN3	251	O95197
AFDKEFKDSYKESTD	RTN3	256	O95197
SEEEAFDFFKYLDAK	PUS7L	211	Q9H0K6
SFFDLLKGYKDDKSD	SIPA1L1	221	O43166
SDDYFSDKGAAKEEK	SHOC1	451	Q5VXU9
LETASDYVKDDKASF	MYCBP2	2121	O75592
DVYFVSESFEDAKEK	TPH1	371	P17752
KYFDNKDDDSDTETS	ZNF639	51	Q9UID6
DKDYTFFKVETENKF	UBE3A	461	Q05086
AKSKFEYVRDFEADD	THG1L	31	Q9NWX6
RSKAFDDIAKYFSKE	SSX6P	21	Q7RTT6
EKTFKYDQFDESSVE	ZNF267	131	Q14586
DEYKKSFTDVFNFDL	ZNF234	151	Q14588
EDEEDLSEYKFAKFA	MYO7A	991	Q13402