Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	DUF4704	NBEA WDFY3	2.59e-04	5	96	2	IPR031570
Domain	DUF4704	NBEA WDFY3	2.59e-04	5	96	2	PF15787
Domain	PH_BEACH	NBEA WDFY3	3.87e-04	6	96	2	PF14844
Domain	ARM-like	NBEA XPO5 DAAM2 WDFY3 DAAM1 GCN1 MN1	4.87e-04	270	96	7	IPR011989
Domain	DAD_dom	DAAM2 DAAM1	7.17e-04	8	96	2	IPR014767
Domain	DAD	DAAM2 DAAM1	7.17e-04	8	96	2	PS51231
Domain	PH-BEACH_dom	NBEA WDFY3	7.17e-04	8	96	2	IPR023362
Domain	-	NBEA WDFY3	7.17e-04	8	96	2	2.30.29.40
Domain	PH_BEACH	NBEA WDFY3	7.17e-04	8	96	2	PS51783
Domain	Drf_GBD	DAAM2 DAAM1	9.19e-04	9	96	2	PF06371
Domain	Drf_FH3	DAAM2 DAAM1	9.19e-04	9	96	2	PF06367
Domain	BEACH	NBEA WDFY3	9.19e-04	9	96	2	PS50197
Domain	Beach	NBEA WDFY3	9.19e-04	9	96	2	PF02138
Domain	-	NBEA WDFY3	9.19e-04	9	96	2	1.10.1540.10
Domain	Beach	NBEA WDFY3	9.19e-04	9	96	2	SM01026
Domain	FH3_dom	DAAM2 DAAM1	9.19e-04	9	96	2	IPR010472
Domain	GTPase-bd	DAAM2 DAAM1	9.19e-04	9	96	2	IPR010473
Domain	BEACH_dom	NBEA WDFY3	9.19e-04	9	96	2	IPR000409
Domain	Drf_FH3	DAAM2 DAAM1	9.19e-04	9	96	2	SM01139
Domain	Drf_GBD	DAAM2 DAAM1	9.19e-04	9	96	2	SM01140
Domain	GBD/FH3_dom	DAAM2 DAAM1	1.40e-03	11	96	2	IPR014768
Domain	GBD_FH3	DAAM2 DAAM1	1.40e-03	11	96	2	PS51232
Domain	FH2	DAAM2 DAAM1	2.63e-03	15	96	2	PS51444
Domain	FH2_Formin	DAAM2 DAAM1	2.63e-03	15	96	2	IPR015425
Domain	FH2	DAAM2 DAAM1	2.63e-03	15	96	2	PF02181
Domain	FH2	DAAM2 DAAM1	2.63e-03	15	96	2	SM00498
Domain	Disintegrin_CS	ADAM11 ADAM33	2.99e-03	16	96	2	IPR018358
Domain	ADAM_CR	ADAM11 ADAM33	3.79e-03	18	96	2	PF08516
Domain	-	ADAM11 ADAM33	4.68e-03	20	96	2	4.10.70.10
Domain	Disintegrin	ADAM11 ADAM33	5.15e-03	21	96	2	PF00200
Domain	DISIN	ADAM11 ADAM33	5.15e-03	21	96	2	SM00050
Domain	AA-permease/SLC12A_dom	SLC12A8 SLC7A1	5.65e-03	22	96	2	IPR004841
Domain	AA_permease	SLC12A8 SLC7A1	5.65e-03	22	96	2	PF00324
Domain	-	XPO5 DAAM2 WDFY3 DAAM1 GCN1	5.78e-03	222	96	5	1.25.10.10
Pubmed	Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities.	IKZF2 IKZF1 IKZF4	2.30e-07	5	100	3	10978333
Pubmed	The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.	COPA RRP1B RAD50 MDN1 ACAD11 PC GCN1 GNL3	4.48e-07	237	100	8	29564676
Pubmed	Defining the membrane proteome of NK cells.	ENDOD1 ATP7B GPAA1 COPA LCLAT1 KIAA2013 RAD50 SLC7A1 MDN1 AHNAK DAAM1 HERC2 GCN1 FUBP3 GNL3	1.25e-06	1168	100	15	19946888
Pubmed	Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos.	IKZF2 IKZF1 IKZF4	1.91e-06	9	100	3	22638570
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	IKZF2 NBEA IKZF1 MDN1 XPO5 TAB1	2.08e-06	129	100	6	23022380
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	LRRC8E AOC2 IRS1 KIAA2013 PLEKHH3 SLC7A1 MDN1 AHNAK PXN WDFY3 HERC2 PC GCN1 BAHCC1	3.43e-06	1105	100	14	35748872
Pubmed	Ikaros confers early temporal competence to mouse retinal progenitor cells.	IKZF2 IKZF1 IKZF4	6.46e-06	13	100	3	18940586
Pubmed	Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor.	IKZF1 IKZF4	8.18e-06	2	100	2	26314708
Pubmed	Helios deficiency has minimal impact on T cell development and function.	IKZF2 IKZF1	8.18e-06	2	100	2	19620299
Pubmed	Genetic variation of COLEC10 and COLEC11 and association with serum levels of collectin liver 1 (CL-L1) and collectin kidney 1 (CL-K1).	COLEC10 COLEC11	8.18e-06	2	100	2	25710878
Pubmed	Collectin Liver 1 and Collectin Kidney 1 of the Lectin Complement Pathway Are Associated With Mortality After Kidney Transplantation.	COLEC10 COLEC11	8.18e-06	2	100	2	27341702
Pubmed	Identification of chick and mouse Daam1 and Daam2 genes and their expression patterns in the central nervous system.	DAAM2 DAAM1	8.18e-06	2	100	2	15464228
Pubmed	Molecular basis of sugar recognition by collectin-K1 and the effects of mutations associated with 3MC syndrome.	COLEC10 COLEC11	8.18e-06	2	100	2	25912189
Pubmed	The inactivation of the sortilin gene leads to a partial disruption of prosaposin trafficking to the lysosomes.	PSAP SORT1	8.18e-06	2	100	2	19732768
Pubmed	Mutual interaction and reciprocal down-regulation between c-met and insulin receptor substrate-1.	IRS1 MET	8.18e-06	2	100	2	20578241
Pubmed	Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2.	DAAM2 DAAM1	8.18e-06	2	100	2	38000028
Pubmed	Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system.	IKZF1 IKZF4	8.18e-06	2	100	2	10218586
Pubmed	LoVo colon cancer cells resistant to oxaliplatin overexpress c-MET and VEGFR-1 and respond to VEGF with dephosphorylation of c-MET.	FLT1 MET	8.18e-06	2	100	2	25647613
Pubmed	CD4+ regulatory T cells lacking Helios and Eos.	IKZF2 IKZF4	8.18e-06	2	100	2	37413709
Pubmed	CL-L1 and CL-K1 Exhibit Widespread Tissue Distribution With High and Co-Localized Expression in Secretory Epithelia and Mucosa.	COLEC10 COLEC11	8.18e-06	2	100	2	30108587
Pubmed	Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes.	IKZF2 IKZF1	8.18e-06	2	100	2	17681952
Pubmed	[Expression characteristics of isoforms of Ikaros and Helios in patients with leukemia and their mechanism].	IKZF2 IKZF1	8.18e-06	2	100	2	22931634
Pubmed	A molecular dissection of the repression circuitry of Ikaros.	IKZF2 IKZF1 IKZF4	8.20e-06	14	100	3	12015313
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	ENDOD1 ATP7B GPAA1 NT5C3A SMPD4 LCLAT1 SORT1 MET MDN1 XPO5 AGMAT WDFY3 PC	1.13e-05	1061	100	13	33845483
Pubmed	A diverse range of gene products are effectors of the type I interferon antiviral response.	NT5C3A MAP3K14 IFIH1	1.52e-05	17	100	3	21478870
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	COPA RRP1B RAD50 MDN1 XPO5 AHNAK HERC2 GCN1 FUBP3 GNL3	1.93e-05	653	100	10	22586326
Pubmed	Ikaros promotes early-born neuronal fates in the cerebral cortex.	IKZF2 IKZF1 IKZF4	2.16e-05	19	100	3	23382203
Pubmed	Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.	IKZF4 IFIH1 HERC2	2.16e-05	19	100	3	22561518
Pubmed	Expression patterns of PAX5, c-Met, and paxillin in neuroendocrine tumors of the lung.	MET PXN	2.45e-05	3	100	2	21043826
Pubmed	Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors.	IKZF2 IKZF1	2.45e-05	3	100	2	9560339
Pubmed	Analysis of Ikaros family splicing variants in human hematopoietic lineages.	IKZF2 IKZF1	2.45e-05	3	100	2	20432734
Pubmed	The trafficking of prosaposin (SGP-1) and GM2AP to the lysosomes of TM4 Sertoli cells is mediated by sortilin and monomeric adaptor proteins.	PSAP SORT1	2.45e-05	3	100	2	15236333
Pubmed	GD3 synthase regulates epithelial-mesenchymal transition and metastasis in breast cancer.	ST8SIA1 MET	2.45e-05	3	100	2	25109336
Pubmed	CDCP1 promotes compensatory renal growth by integrating Src and Met signaling.	CDCP1 MET	2.45e-05	3	100	2	33574034
Pubmed	Growth factor receptor expression in anal squamous lesions: modifications associated with oncogenic human papillomavirus and human immunodeficiency virus.	FLT1 MET	2.45e-05	3	100	2	19716155
Pubmed	Aberrant Ikaros, Aiolos, and Helios expression in Hodgkin and non-Hodgkin lymphoma.	IKZF2 IKZF1	2.45e-05	3	100	2	18332232
Pubmed	Association of Polymorphisms of MASP1/3, COLEC10, and COLEC11 Genes with 3MC Syndrome.	COLEC10 COLEC11	2.45e-05	3	100	2	32751929
Pubmed	Overexpression of novel short isoforms of Helios in a patient with T-cell acute lymphoblastic leukemia.	IKZF2 IKZF1	2.45e-05	3	100	2	11937265
Pubmed	No somatic genetic change in the paxillin gene in nonsmall-cell lung cancer.	MET PXN	2.45e-05	3	100	2	19353596
Pubmed	Expression patterns of Ikaros family members during positive selection and lineage commitment of human thymocytes.	IKZF2 IKZF1	2.45e-05	3	100	2	27502439
Pubmed	Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations.	PSAP SORT1	2.45e-05	3	100	2	28541286
Pubmed	Identification and comparative expression analyses of Daam genes in mouse and Xenopus.	DAAM2 DAAM1	2.45e-05	3	100	2	15533824
Pubmed	Hepatocyte growth factor promotes lymphatic vessel formation and function.	MET LYVE1	2.45e-05	3	100	2	16052207
Pubmed	Structural studies on a protein-binding zinc-finger domain of Eos reveal both similarities and differences to classical zinc fingers.	IKZF1 IKZF4	4.89e-05	4	100	2	15491138
Pubmed	A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells.	IKZF2 IKZF4	4.89e-05	4	100	2	22961053
Pubmed	Heteromeric complexes of native collectin kidney 1 and collectin liver 1 are found in the circulation with MASPs and activate the complement system.	COLEC10 COLEC11	4.89e-05	4	100	2	24174618
Pubmed	Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions.	IRS1 PIN4	4.89e-05	4	100	2	23720771
Pubmed	MET, HGF, EGFR, and PXN gene copy number in lung cancer using DNA extracts from FFPE archival samples and prognostic significance.	MET PXN	4.89e-05	4	100	2	19817696
Pubmed	Disheveled-associated activator of morphogenesis 2 promotes invasion of colorectal cancer by activating PAK1 and promoting MMP7 expression.	DAAM2 DAAM1	4.89e-05	4	100	2	33974241
Pubmed	Collectin liver 1 and collectin kidney 1 and other complement-associated pattern recognition molecules in systemic lupus erythematosus.	COLEC10 COLEC11	4.89e-05	4	100	2	26154564
Pubmed	Syntenic assignment of human serotonin receptor subtype 2 (HTR2), esterase D (ESD), and fms-related tyrosine kinase (FLT) homologs to bovine chromosome 12.	FLT1 ESD	4.89e-05	4	100	2	8672130
Pubmed	Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion.	MET HPN	4.89e-05	4	100	2	26165838
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	COPA RRP1B NT5C3A MAP3K14 SMPD4 LCLAT1 RAD50 SORT1 MDN1 XPO5 AHNAK GCN1 FUBP3 SDHB	6.47e-05	1440	100	14	30833792
Pubmed	Comparative linkage mapping of human chromosome 13 and bovine chromosome 12.	FLT1 ESD	8.14e-05	5	100	2	9027485
Pubmed	Decreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes.	GPD1 PC	8.14e-05	5	100	2	19296078
Pubmed	PECAM/eGFP transgenic mice for monitoring of angiogenesis in health and disease.	FLT1 LYVE1	8.14e-05	5	100	2	30514882
Pubmed	Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus.	IKZF1 IFIH1	8.14e-05	5	100	2	22046141
Pubmed	Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility.	IRS1 PXN	8.14e-05	5	100	2	10082579
Pubmed	Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1.	DAAM2 DAAM1	8.14e-05	5	100	2	11779461
Pubmed	Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.	FLT1 MAP3K14 NR4A1 MET PXN TAB1 DAAM1	1.02e-04	371	100	7	25241761
Pubmed	Direct protein interactions are responsible for Ikaros-GATA and Ikaros-Cdk9 cooperativeness in hematopoietic cells.	IKZF1 IKZF4	1.22e-04	6	100	2	23732910
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	RGS3 MDN1 TAB1 MGA GCN1 FUBP3	1.40e-04	272	100	6	31010829
Pubmed	Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series.	RPIA PC ENO3 SDHB	1.54e-04	93	100	4	27215380
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	IFT27 COPA ESD RAD50 TAB1 GCN1 FUBP3 SDHB	1.58e-04	534	100	8	35032548
Pubmed	Endosomal sorting by Semaphorin 4A in retinal pigment epithelium supports photoreceptor survival.	PSAP SORT1	1.70e-04	7	100	2	22465952
Pubmed	Essential role of Gab1 for signaling by the c-Met receptor in vivo.	FLT1 MET	1.70e-04	7	100	2	10995442
Pubmed	Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.	RGS3 IFIH1 ACAD11 TAB1 DAAM1 GNL3	1.73e-04	283	100	6	21903422
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	IFT27 GPBP1 RAD50 PIN4 PXN TAB1 HERC2 PC MGA GNL3	1.77e-04	853	100	10	28718761
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	COPA RRP1B SMPD4 NBEA SORT1 AHNAK PXN TAB1 HERC2 PC GCN1	2.19e-04	1049	100	11	27880917
Pubmed	Placental defects lead to embryonic lethality in mice lacking the Formin and PCP proteins Daam1 and Daam2.	DAAM2 DAAM1	2.27e-04	8	100	2	32353019
Pubmed	The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting.	PSAP SORT1	2.27e-04	8	100	2	22431521
Pubmed	The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway.	MAP3K14 TAB1	2.27e-04	8	100	2	10094049
Pubmed	Rab11-FIP1 and Rab11-FIP5 Regulate pIgR/pIgA Transcytosis through TRIM21-Mediated Polyubiquitination.	NBEA PC SDHB	2.27e-04	41	100	3	34638806
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	ENDOD1 NAGK NT5C3A GFUS PLEKHH3 DGCR8 GCN1 FUBP3 GNL3	2.67e-04	732	100	9	34732716
Pubmed	Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.	IKZF2 IRS1 HERC2	2.80e-04	44	100	3	27534441
Pubmed	Helios transcription factor expression depends on Gsx2 and Dlx1&2 function in developing striatal matrix neurons.	IKZF2 IKZF1	2.91e-04	9	100	2	22142223
Pubmed	PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature.	RGS3 LYVE1	2.91e-04	9	100	2	15687262
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	COPA XPO5 AHNAK HERC2 GCN1	3.03e-04	202	100	5	33005030
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	RAP1GAP NAGK PSAP COPA NBEA CPNE5 DAAM2 DGCR8 WDFY3 HERC2 PC ST18	3.23e-04	1285	100	12	35914814
Pubmed	Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.	COPA SLC7A1 XPO5 GCN1	3.26e-04	113	100	4	30352685
Pubmed	Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.	RPIA PC ENO3 SDHB	3.37e-04	114	100	4	28245920
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	COPA RRP1B MDN1 ACAD11 ZNF358 DGCR8 HERC2 GCN1 GNL3	3.48e-04	759	100	9	35915203
Pubmed	Association of a common AGO1 variant with lung cancer risk: a two-stage case-control study.	XPO5 DGCR8	3.63e-04	10	100	2	20721975
Pubmed	Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates.	FLT1 MET	3.63e-04	10	100	2	18273061
Pubmed	Glyceroneogenesis is the dominant pathway for triglyceride glycerol synthesis in vivo in the rat.	GPD1 PC	3.63e-04	10	100	2	18662986
Pubmed	Discovery and refinement of loci associated with lipid levels.	IKZF1 IRS1 SORT1 MET ACAD11	3.70e-04	211	100	5	24097068
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	ENDOD1 COPA NT5C3A LCLAT1 KIAA2013 SORT1 SLC7A1 XPO5 GCN1 FUBP3	3.89e-04	942	100	10	31073040
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	COPA RAD50 MDN1 XPO5 AHNAK GCN1	4.06e-04	332	100	6	32786267
Pubmed	Flt1/VEGFR1 heterozygosity causes transient embryonic edema.	FLT1 LYVE1	4.43e-04	11	100	2	27251772
Pubmed	Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels.	FLT1 MET	4.43e-04	11	100	2	17981115
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	ESD RAD50 XPO5 FUBP3 GNL3	4.47e-04	220	100	5	35785414
Pubmed	Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death.	ACAD11 TAB1 TAF1L	4.60e-04	52	100	3	35361962
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	COPA RRP1B IKZF1 RAD50 MDN1 AHNAK	4.60e-04	340	100	6	29478914
Pubmed	A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers.	IKZF1 XPO5 MGA GCN1	4.78e-04	125	100	4	21654808
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	NAGK RRP1B RAD50 ACAD11 XPO5 PXN TAB1 GCN1 FUBP3 SDHB	5.05e-04	974	100	10	28675297
Pubmed	Impaired lymphoid organ development in mice lacking the heparan sulfate modifying enzyme glucuronyl C5-epimerase.	FLT1 LYVE1	5.30e-04	12	100	2	20208005
Pubmed	Mitochondrial complex II regulates a distinct oxygen sensing mechanism in monocytes.	MET SDHB	5.30e-04	12	100	2	28204537
Pubmed	Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.	COPA RRP1B ESD XPO5 PC GCN1 FUBP3 GNL3	5.36e-04	641	100	8	36057605
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	COLEC10 CDCP1 VMO1 NLRC4 LCLAT1 COLEC11 LYVE1 LRRN4CL CD163L1 ADAM33	5.50e-04	985	100	10	12975309
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	RAD50 MDN1 AHNAK PC GNL3	5.92e-04	234	100	5	36243803
Cytoband	1p36.1-p35	RAP1GAP SDHB	1.71e-04	9	101	2	1p36.1-p35
Cytoband	19p13.2	LRRC8E ZNF358 ELAVL3 OLFM2	1.69e-03	229	101	4	19p13.2
Cytoband	1p36.22	KIAA2013 DISP3	3.04e-03	37	101	2	1p36.22
Cytoband	3p21.1	CHDH GNL3	3.90e-03	42	101	2	3p21.1
Cytoband	11q21	ENDOD1 HEPHL1	4.27e-03	44	101	2	11q21
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEA WDFY3	4.23e-04	9	63	2	1230
GeneFamily	Collectins	COLEC10 COLEC11	5.28e-04	10	63	2	491
ToppCell	PBMC-Mild-cDC_9\|Mild / Compartment, Disease Groups and Clusters	FLT1 IKZF2 PSAP CDCP1 PLEKHH3 IFIH1 LYVE1	1.98e-07	184	100	7	2e0c9a2c40c892a2d435eafb31f1f838de9baf15
ToppCell	control-Myeloid-Mast_cell\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ENDOD1 CHDH SLC12A8 NBEA ST8SIA1 MS4A2 ABCA5	2.55e-07	191	100	7	afebdc59a1f884ce3f2f5fe040e16b0e95e4e7c5
ToppCell	facs-Marrow-B-cells-24m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PSAP CHDH ADAM11 ST8SIA1 AHNAK DISP3	1.02e-06	147	100	6	9d7e965fe61bd7b31e09c4b2129a5a98c36f4811
ToppCell	facs-Marrow-B-cells-24m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PSAP CHDH ADAM11 ST8SIA1 AHNAK DISP3	1.02e-06	147	100	6	38552953ff65a0fc20bee6ef57dc5885306ad18b
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IRS1 ST8SIA1 ABCA5 DAAM1 PC ST18	3.09e-06	178	100	6	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PSAP NBEA ABCA5 PC MGA ST18	5.22e-06	195	100	6	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	LAM-Endothelial-LymEndo\|Endothelial / Condition, Lineage and Cell class	ENDOD1 GFUS SLC7A1 LYVE1 AHNAK GNL3	5.69e-06	198	100	6	ba64b1c95dfaa995045239d412e725596f6c482e
ToppCell	LPS-IL1RA+antiTNF-Unknown-Endothelial-Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IFT27 SMPD4 COLEC10 MDN1 RAB30	2.55e-05	154	100	5	16fdafb5c64d2db321554f87129a962d113f1668
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 PSAP SPINT4 PXN MN1	2.71e-05	156	100	5	ea9223bb6450b22df11efa1705ab72dab005244a
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 PSAP SPINT4 PXN MN1	2.71e-05	156	100	5	586b5509074c4cc359e9e31a968c2ded71c994ca
ToppCell	Adult-Immune-mast_cell-D175\|Adult / Lineage, Cell type, age group and donor	IKZF1 ST8SIA1 RGS3 AGMAT SP140	2.97e-05	159	100	5	9f53fe2e0f25448d62a591c8e528e9a49b5400d5
ToppCell	Adult-Immune-mast_cell\|Adult / Lineage, Cell type, age group and donor	IKZF1 ST8SIA1 CPNE5 MS4A2 AGMAT	3.16e-05	161	100	5	44f5c0256b3ce264a6c7b62740f32dcd45ee052d
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma\|TCGA-Brain / Sample_Type by Project: Shred V9	MDN1 DISP3 CNTN3 DAAM2 PC	3.16e-05	161	100	5	347edb0de10850b7d16c40945751033289289c9b
ToppCell	facs-Heart-RA-18m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 RGS3 COLEC11 LYVE1 HMCN1	3.87e-05	168	100	5	06dc5b2d356d3a9454b10bba6f3b9ead2a0a7d46
ToppCell	facs-Heart-RA-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 RGS3 COLEC11 LYVE1 HMCN1	3.87e-05	168	100	5	1002f058a340763e3d8de0bd1f0547a903526ec6
ToppCell	facs-Marrow-T-cells-3m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHDH ST8SIA1 ABCA5 AHNAK AGMAT	4.21e-05	171	100	5	6a0fafb8fd9fc7671618eeb2bf528ce8ce86b794
ToppCell	facs-Marrow-T-cells-3m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHDH ST8SIA1 ABCA5 AHNAK AGMAT	4.21e-05	171	100	5	e02b5831768dbb1b68998b672e55c9680ab0cc86
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Airway_fibro\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	ADAM11 CPNE5 LCLAT1 ADAM33 MN1	4.45e-05	173	100	5	b23b408acc29a667cce104429afef1a6cf2720a5
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Ccr7+_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAP1GAP ST8SIA1 RAB30 ENO3 BAHCC1	4.57e-05	174	100	5	7be0c6248e77f2d0260b852b01e17892f7828f1b
ToppCell	tumor_Lymph_Node_/_Brain-B_lymphocytes-Undetermined\|B_lymphocytes / Location, Cell class and cell subclass	IKZF2 IKZF4 MET ABCA5 ENO3	4.57e-05	174	100	5	390bd41ef114464f3db3e0cac4e67fe7571b4c23
ToppCell	droplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RAP1GAP ST8SIA1 RAB30 ENO3 BAHCC1	4.70e-05	175	100	5	1b910c08d2bfbcc77431ee66103e63a11a9d39fe
ToppCell	facs-Marrow-T_cells-18m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHDH ADAM11 ST8SIA1 ABCA5 AHNAK	4.82e-05	176	100	5	74f851a398c7562dd713bc0d8d488c0037243112
ToppCell	facs-Marrow-T_cells-18m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHDH ADAM11 ST8SIA1 ABCA5 AHNAK	4.82e-05	176	100	5	31b5459a978d5cdde0af03a77401e0464d8c95ba
ToppCell	facs-Heart-RV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LCLAT1 PLEKHH3 COLEC11 MDN1 DAAM2	4.96e-05	177	100	5	7c3d46ebd7e8726be6871aa9763e281fc0ec6ac8
ToppCell	facs-Heart-RV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LCLAT1 PLEKHH3 COLEC11 MDN1 DAAM2	4.96e-05	177	100	5	e7b1f3092e6b8d0d580f82648035f5ad12be6961
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 COLEC10 VMO1 HMCN1 DAAM2	4.96e-05	177	100	5	8ef41ee5d63737b810ad7371b0437625e7e1badf
ToppCell	T_cells-TFH-like_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	FLT1 ETV7 ST8SIA1 IKZF4 AGMAT	5.09e-05	178	100	5	e2ae43e5ec31de6197f2cbd6089f944adbf0a163
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPAA1 IKZF4 COLEC11 TBCK TAB1	5.23e-05	179	100	5	e880c507f11ce75d104593a4ca29f0295f8125e8
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAP3K14 NBEA IKZF4 COLEC11 OLFM2	5.23e-05	179	100	5	dd94ebe69ade6f51b94058abe066216f0de9feda
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAP1GAP ATP7B IRS1 COLEC11 XPO5	5.51e-05	181	100	5	4e81ec1580e9acb22c32c465eb46f83d1e9e424e
ToppCell	(2)_NK/T-(230)_CD4+/CD25+_Reg_T_cell\|(2)_NK/T / immune cells in Peripheral Blood (logTPM normalization)	IKZF2 CHDH ETV7 IKZF4 RAB30	5.51e-05	181	100	5	ad14c7111d4fb924afd233cb114447f195373a7c
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAP1GAP ATP7B IRS1 COLEC11 XPO5	5.51e-05	181	100	5	ad30c01290fb98adbd0caed301a584761212c977
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 COLEC10 VMO1 HMCN1 DAAM2	5.51e-05	181	100	5	4df7972f88117108698efd06b124b232f8588981
ToppCell	facs-Marrow-B-cells-18m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PSAP CHDH ADAM11 ST8SIA1 AHNAK	5.51e-05	181	100	5	782716b8b1d447d2bbe09a693fa5ed7ebeac0efb
ToppCell	facs-Marrow-B-cells-18m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PSAP CHDH ADAM11 ST8SIA1 AHNAK	5.51e-05	181	100	5	e2481291c236105774c53883e6f20da11941df9b
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAP1GAP ATP7B IRS1 COLEC11 XPO5	5.51e-05	181	100	5	3a3268a4dff8ffcb79e09f46490e138c96f8d916
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 COLEC10 VMO1 HMCN1 DAAM2	5.51e-05	181	100	5	cbb530566893281289026bfd93adf721decd4ca3
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPD1 ATP7B CHDH IRS1 PC	5.66e-05	182	100	5	770ce9f3f4538d0181a0181543841bc964c68274
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPD1 ATP7B CHDH IRS1 PC	5.66e-05	182	100	5	77ab860e2add49dad0c1ffbfc64278ad499dfbd5
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPD1 ATP7B CHDH IRS1 PC	5.66e-05	182	100	5	4921c7d5687cc79f896b39753bb621d7e3d2972f
ToppCell	B_cells-ISG-high_B_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	ENDOD1 NT5C3A CPNE5 IFIH1 SP140	5.80e-05	183	100	5	dc2b00e920efa1dcc2a6265cd1024e3249c9974f
ToppCell	facs-Heart-RA-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZSWIM5 ADAM11 COLEC11 DAAM2 OLFM2	5.80e-05	183	100	5	0f02136359787bd78146617990968baa47a65d86
ToppCell	facs-Heart-RA-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZSWIM5 ADAM11 COLEC11 DAAM2 OLFM2	5.80e-05	183	100	5	2f0dcc65ad4d90ef946919b4462280fdd20c5ea0
ToppCell	5'-Adult-LymphNode-Hematopoietic-Myeloid-Macrophages\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NAGK PSAP VMO1 NLRC4 LYVE1	6.43e-05	187	100	5	00930e407beaa337f72533a69f32d150faad8b9a
ToppCell	facs-Heart-RA-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 RGS3 COLEC11 LYVE1 HMCN1	6.59e-05	188	100	5	4ddb11a90bf3baa7237bde304db44dfcc56aed52
ToppCell	facs-Heart-RA-3m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 RGS3 COLEC11 LYVE1 HMCN1	6.59e-05	188	100	5	e47e66906922d5c69b1aafe28face0787d3fc563
ToppCell	T_cells-ISG-high_CD4+_T_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	NT5C3A ETV7 IRS1 IFIH1 SP140	6.59e-05	188	100	5	6f8946d4710f6e32c937213f99b790b098b8819c
ToppCell	5'-Adult-SmallIntestine-Epithelial-goblet-Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RAP1GAP CHDH SLC12A8 GFUS MUC2	6.59e-05	188	100	5	91fa9cc29cbc88d3c29590ecee5c8ce858ac0aa7
ToppCell	5'-Adult-SmallIntestine-Epithelial-goblet\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RAP1GAP CHDH SLC12A8 GFUS MUC2	6.76e-05	189	100	5	6f4f2911fcbf3b43718b6183dbd9c970d4c19607
ToppCell	LV-08._Macrophage\|World / Chamber and Cluster_Paper	IKZF1 LYVE1 CD163L1 DAAM2 ST18	7.11e-05	191	100	5	e7a0bc46ba9ba772636a583f3387748418e18832
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	RAP1GAP ZSWIM5 NR4A1 MET HPN	7.11e-05	191	100	5	34cc997e4e5c727495f321e6807a84aa124da486
ToppCell	BAL-Severe-Myeloid-TRAM-TRAM3\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	GPD1 CHDH CDCP1 VMO1 SORT1	7.11e-05	191	100	5	2b10a73c5d80e83d67a7121fb004a1aa86a537ef
ToppCell	BAL-Severe-Myeloid-TRAM-TRAM3-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	GPD1 CHDH CDCP1 VMO1 SORT1	7.11e-05	191	100	5	02e1ae144da7274171e055356d10e8d175c5347f
ToppCell	COVID-19-kidney-Stressed_EC\|kidney / Disease (COVID-19 only), tissue and cell type	FLT1 NR4A1 CPNE5 LYVE1 PXN	7.11e-05	191	100	5	d35aa842b813ea0eff7362abc894cca4e86b2fb2
ToppCell	Severe_COVID-19-Myeloid-TRAM3\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	GPD1 CHDH CDCP1 VMO1 SORT1	7.11e-05	191	100	5	05867b96199a46a415848409130697c810d18937
ToppCell	BAL-Severe-Myeloid-TRAM\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	GPD1 CHDH CDCP1 VMO1 SORT1	7.11e-05	191	100	5	4c4f50a502e3f6768a89df686fa2830b83b8b33f
ToppCell	BAL-Severe-Myeloid-TRAM\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GPD1 CHDH CDCP1 VMO1 SORT1	7.11e-05	191	100	5	de7c88bb46f794291025ef121a89fcd94dea4ffe
ToppCell	BAL-Severe-Myeloid-TRAM-TRAM3\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GPD1 CHDH CDCP1 VMO1 SORT1	7.28e-05	192	100	5	34505a13b8a47c9286c560122fa7861b9c331a08
ToppCell	COVID-19-Myeloid-TRAM1\|COVID-19 / Condition, Lineage and Cell class	GPD1 CHDH CDCP1 VMO1 SORT1	7.28e-05	192	100	5	52b8578699325b0d35a2d3ba36772096130ccc0c
ToppCell	BAL-Severe-Myeloid-TRAM-TRAM3-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GPD1 CHDH CDCP1 VMO1 SORT1	7.28e-05	192	100	5	57c1410ebf90c230993e065eb78385daa3360960
ToppCell	facs-Lung-nan-3m-Epithelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAP1GAP ATP7B CDCP1 MET HPN	7.28e-05	192	100	5	cca2d0fedfbd946c54d6f4fc45887117c8dae58a
ToppCell	facs-Lung-EPCAM-18m-Epithelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPD1 RAP1GAP CDCP1 MET HPN	7.28e-05	192	100	5	12096302a3a4d26e21ca04357aa557143f482155
ToppCell	myeloid-macrophage\|World / Lineage and Cell class	NAGK PSAP VMO1 LYVE1 CD163L1	7.46e-05	193	100	5	b13e694123b87ed8ad1786feb996398ddd84e94b
ToppCell	3'-Adult-LargeIntestine-Epithelial-goblet\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RAP1GAP NR4A1 GFUS CD163L1 MUC2	7.65e-05	194	100	5	1a188e52f2f0b6eca3e8d4a4671d9beab0fbbb88
ToppCell	CF-Myeloid-cDC\|Myeloid / Disease state, Lineage and Cell class	MAP3K14 VMO1 SLC7A1 RAB30 ST18	7.65e-05	194	100	5	3feb8a0ba3368673c53e9cbd4980e73d18697718
ToppCell	moderate-Myeloid-Monocyte-derived_Macrophage\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ENDOD1 PSAP NT5C3A ETV7 IFIH1	7.83e-05	195	100	5	9c9634906168239cf978adb398787692437bf9e7
ToppCell	severe_COVID-19-Non-classical_Monocyte\|World / disease group, cell group and cell class (v2)	PSAP NR4A1 VMO1 LYVE1 DAAM2	7.83e-05	195	100	5	72928a1d987a3a5361c666f3972292aefec5f548
ToppCell	3'-Adult-LargeIntestine-Epithelial-goblet-BEST2+_Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RAP1GAP NR4A1 GFUS CD163L1 MUC2	7.83e-05	195	100	5	3365768101454060b9ea96ef6b426c76c150bc8f
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PSAP NBEA PC MGA ST18	7.83e-05	195	100	5	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	Mild-CD4+_T_activated\|Mild / Disease group and Cell class	GPBP1 NT5C3A ETV7 IFIH1 SP140	8.03e-05	196	100	5	daa1c3322d81e649161e889e1d78451d2d425d09
ToppCell	Mild-CD4+_T_activated\|World / Disease group and Cell class	ENDOD1 GPBP1 NT5C3A ETV7 IFIH1	8.03e-05	196	100	5	417b4fc2e4388f34c410576131b02936f93e46b6
ToppCell	Sigmoid-B_cell-B_cell_IgG_Plasma\|B_cell / Region, Cell class and subclass	RAP1GAP PSAP ETV7 COLEC11 AHNAK	8.42e-05	198	100	5	305d7ae9b070ac7211638a5282374c02bf13af40
ToppCell	Bronchus_Control_(B.)-Immune-TX-B_cells\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	GPBP1 IKZF1 CPNE5 RAB30 SP140	8.42e-05	198	100	5	6231c44a909dd06f85c8210814e976a5f29148d0
ToppCell	3'-GW_trimst-1-SmallIntestine-Neuronal-neurons_A-Branch_A1_(iMN)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NBEA ELAVL3 OLFM2 ST18 ENO3	8.42e-05	198	100	5	dac7b68bb8f1c4d8aa7fdfada61f79956866e874
ToppCell	Mild-CD8+_T_activated\|Mild / Disease group and Cell class	ENDOD1 GPBP1 NT5C3A IFIH1 SP140	8.42e-05	198	100	5	ceac1b51bacfd0dd7fe7c6a666f7927055e1f380
ToppCell	medial-Endothelial-Lymphatic-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GFUS CPNE5 SLC7A1 LYVE1 LRRN4CL	8.42e-05	198	100	5	41983d405215b974044e2e9e6c212b134336a6fe
ToppCell	medial-2-Endothelial-Lymphatic\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GFUS CPNE5 SLC7A1 LYVE1 LRRN4CL	8.42e-05	198	100	5	e4274584512a72270087a1ab104fab449a2f83bc
ToppCell	CV-Mild-1\|CV / Virus stimulation, Condition and Cluster	IKZF2 NT5C3A ETV7 IFIH1 SP140	8.42e-05	198	100	5	4b078714c49e7befb7b113d72485e712236d35fa
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IKZF2 NBEA VMO1 AHNAK FRMPD2B	8.42e-05	198	100	5	d0ecace1fad24ce50b0935036fabb07e6c9e372d
ToppCell	medial-Endothelial-Lymphatic\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GFUS CPNE5 SLC7A1 LYVE1 LRRN4CL	8.42e-05	198	100	5	1760fede363544bc0fa2e22fe36aff522abd2525
ToppCell	LPS_IL1RA-Hematopoietic_Lymphocytic-B_cells-B-cells\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	NT5C3A IKZF1 NR4A1 RAB30 SP140	8.62e-05	199	100	5	0eb8c72edcd34fe0f7ab9438c9c872d63576ef3a
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_macrophage\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PSAP SORT1 LYVE1 DAAM2 WDFY3	8.62e-05	199	100	5	b827dd8a249f904a0ff930a6c4d3b00fb7bc6fb1
ToppCell	LPS_IL1RA-Hematopoietic_Lymphocytic-B_cells\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	NT5C3A IKZF1 NR4A1 RAB30 SP140	8.62e-05	199	100	5	2cdc8ae6357723b9e7c0c66be656e6f748a6aa2d
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PSAP SORT1 LYVE1 DAAM2 WDFY3	8.62e-05	199	100	5	0f3ce61bbae69f7e333ed8dacf7257645624e163
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Myeloid\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PSAP VMO1 LYVE1 MS4A2 CD163L1	8.62e-05	199	100	5	a4785c1921a3de18a9190e4d674ede6a90f80004
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_macrophage-macrophage\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PSAP SORT1 LYVE1 DAAM2 WDFY3	8.62e-05	199	100	5	c0dcdda30485bb920d3706dcfb06f11b76b6ea37
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Pericyte-Pericyte_2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	NBEA COLEC10 PLEKHH3 DAAM2 OLFM2	8.83e-05	200	100	5	d2fcd3bd7c3223875f027eeb48ff621192a5f242
ToppCell	mLN-Macrophage\|mLN / Region, Cell class and subclass	CDCP1 NLRC4 LYVE1 CD163L1 WDFY3	8.83e-05	200	100	5	68d709afd226241e002dae6d6820bccd1cfd87a1
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Lymphocytic-B_cells\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	NT5C3A IKZF1 NR4A1 RAB30 SP140	8.83e-05	200	100	5	d124acbe5d46220850fe485ed78f032daddca5b1
ToppCell	mLN-(6)_Macrophage-(61)_LYVE1_Macrophage\|mLN / shred on region, Cell_type, and subtype	CDCP1 VMO1 NLRC4 LYVE1 WDFY3	8.83e-05	200	100	5	a20f5ec61d492d8a2adf695ec304b5d57296aa8f
ToppCell	mLN-Macrophage-LYVE1_Macrophage\|mLN / Region, Cell class and subclass	CDCP1 VMO1 NLRC4 LYVE1 WDFY3	8.83e-05	200	100	5	89cf739a3c2f5d30e547404f2f2ec6500cd1d65d
ToppCell	mLN-(6)_Macrophage\|mLN / shred on region, Cell_type, and subtype	CDCP1 NLRC4 LYVE1 CD163L1 WDFY3	8.83e-05	200	100	5	6dcba82a7d322102bae205543086e84c7655b3e0
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Lymphocytic-B_cells-B-cells\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	NT5C3A IKZF1 NR4A1 RAB30 SP140	8.83e-05	200	100	5	c07e37db9d50b91378d9c8355168745560cdbd25
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Pericyte-Pericyte_2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	COLEC10 PLEKHH3 ELAVL3 DAAM2 OLFM2	8.83e-05	200	100	5	786f1ae53e60b5ffbf4bfd393d10b802478148b3
ToppCell	LPS-IL1RA-Epithelial_alveolar-Mes-Like-AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CHDH CDCP1 MET HPN	9.24e-05	105	100	4	8d5528ae2bdba17e2474a7ca07fc8596d1b04647
ToppCell	(61)_LYVE1_Macrophage\|World / shred on Cell_type and subtype	CDCP1 VMO1 NLRC4 LYVE1 WDFY3	1.01e-04	206	100	5	711e961a9a03bfd2f0958bd14f25f7f207a2f2b5
ToppCell	Thalamus-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)--\|Thalamus / BrainAtlas - Mouse McCarroll V32	NLRC4 LYVE1 MS4A2 ADAM33	1.15e-04	111	100	4	a1b7940c6fa0e5a58aa4798b604469d79f33fa44
ToppCell	Thalamus-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	NLRC4 LYVE1 MS4A2 ADAM33	1.15e-04	111	100	4	d1ec8e8e9adb11511b4ef363cc6f99286e2cc842
ToppCell	Thalamus-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)\|Thalamus / BrainAtlas - Mouse McCarroll V32	NLRC4 LYVE1 MS4A2 ADAM33	1.15e-04	111	100	4	567e5ac2c78d45db207067f0f152bb24ed048c50
ToppCell	Thalamus-Hematopoietic-MACROPHAGE-MP1(C1qb)\|Thalamus / BrainAtlas - Mouse McCarroll V32	NLRC4 LYVE1 MS4A2 ADAM33	1.15e-04	111	100	4	fd7aa25e83a0d762969e3966a658652da40c490e
Drug	Piromidic acid [19562-30-2]; Up 200; 13.8uM; HL60; HT_HG-U133A	AOC2 SLC12A8 NR4A1 MET MS4A2 PXN ELAVL3 DGCR8	2.38e-06	199	98	8	2996_UP
Drug	Sulfamerazine [127-79-7]; Up 200; 15.2uM; MCF7; HT_HG-U133A	GPD1 AOC2 ADAM11 IKZF4 ZNF358 ELAVL3 DGCR8 ENO3	2.47e-06	200	98	8	4740_UP
Drug	HCDs	CNTN3 PC	1.83e-05	2	98	2	CID000083497
Drug	N6-methyladenosine [1867-73-8]; Up 200; 14.2uM; HL60; HT_HG-U133A	IFT27 RAP1GAP MAP3K14 COLEC11 SLC7A1 CDADC1 DGCR8	2.17e-05	195	98	7	1271_UP
Drug	Ranitidine hydrochloride [66357-59-3]; Down 200; 11.4uM; MCF7; HT_HG-U133A	IKZF1 RAD50 SORT1 MET RAB30 PIN4 WDFY3	2.25e-05	196	98	7	5425_DN
Drug	Suprofen [40828-46-4]; Down 200; 15.4uM; MCF7; HT_HG-U133A	IFT27 SLC12A8 MET RAB30 TAB1 ENO3 BAHCC1	2.32e-05	197	98	7	3343_DN
Drug	Ajmalicine hydrochloride [4373-34-6]; Down 200; 10.2uM; MCF7; HT_HG-U133A	RRP1B IKZF1 NR4A1 RGS3 SORT1 RAB30 DGCR8	2.32e-05	197	98	7	5459_DN
Drug	Testosterone propionate [57-85-2]; Up 200; 11.6uM; HL60; HT_HG-U133A	IFT27 RAP1GAP RRP1B MAP3K14 NR4A1 RGS3 CDADC1	2.48e-05	199	98	7	1295_UP
Disease	Squamous cell carcinoma of the head and neck	ATP7B IRS1 MET TBCK	2.85e-05	52	99	4	C1168401
Disease	Malpuech facial clefting syndrome	COLEC10 COLEC11	3.34e-05	3	99	2	C0796032
Disease	Craniofacial ulnar renal syndrome	COLEC10 COLEC11	3.34e-05	3	99	2	C4303860
Disease	Liver diseases	ATP7B ST8SIA1 SORT1 ENO3	1.03e-04	72	99	4	C0023895
Disease	Liver Dysfunction	ATP7B ST8SIA1 SORT1 ENO3	1.03e-04	72	99	4	C0086565
Disease	collectin-11 measurement	COLEC10 COLEC11	1.11e-04	5	99	2	EFO_0008088
Disease	Autoinflammatory disorder	COPA NLRC4 IFIH1	2.22e-04	35	99	3	C3860213
Disease	collectin-10 measurement	COLEC10 COLEC11	3.95e-04	9	99	2	EFO_0801491
Disease	Malignant neoplasm of kidney	ATP7B MET SDHB	4.69e-04	45	99	3	C0740457
Disease	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	IKZF1 MGA	7.20e-04	12	99	2	C0023485
Disease	sex interaction measurement, inflammatory bowel disease	IKZF1 RAD50 IFIH1	8.47e-04	55	99	3	EFO_0003767, EFO_0008343
Disease	Papillary Renal Cell Carcinoma	FLT1 VMO1 MET AHNAK	9.25e-04	128	99	4	C1306837
Disease	Renal Cell Carcinoma	FLT1 VMO1 MET AHNAK	9.25e-04	128	99	4	C0007134
Disease	Sarcomatoid Renal Cell Carcinoma	FLT1 VMO1 MET AHNAK	9.25e-04	128	99	4	C1266043
Disease	Chromophobe Renal Cell Carcinoma	FLT1 VMO1 MET AHNAK	9.25e-04	128	99	4	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	FLT1 VMO1 MET AHNAK	9.25e-04	128	99	4	C1266044
Disease	Prostatic Neoplasms	NAGK ATP7B IRS1 MET SLC7A1 HPN MGA TAF1L	1.12e-03	616	99	8	C0033578
Disease	Malignant neoplasm of prostate	NAGK ATP7B IRS1 MET SLC7A1 HPN MGA TAF1L	1.12e-03	616	99	8	C0376358
Disease	eosinophil percentage of granulocytes	IKZF2 IKZF1 IKZF4 RAD50 SP140	1.17e-03	234	99	5	EFO_0007996
Disease	eosinophil count	IKZF2 NAGK MAP3K14 IKZF1 COLEC10 LCLAT1 IKZF4 RAD50 IFIH1 MDN1 MUC2 BAHCC1 SP140	1.41e-03	1488	99	13	EFO_0004842
Disease	Vitiligo	IKZF4 IFIH1	1.47e-03	17	99	2	C0042900
Disease	visfatin measurement	IKZF1 TAB1	1.47e-03	17	99	2	EFO_0801230
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	FLT1 VMO1 MET AHNAK	1.58e-03	148	99	4	C0279702
Disease	Abnormality of refraction	FLT1 RRP1B CHDH NBEA ST8SIA1 RGS3 FRMPD2B ST18	1.95e-03	673	99	8	HP_0000539
Disease	N-glycan measurement	IKZF1 TAB1	2.46e-03	22	99	2	EFO_0004999
Disease	Hereditary Paraganglioma-Pheochromocytoma Syndrome	MET SDHB	2.69e-03	23	99	2	C1708353
Disease	breast cancer (implicated_via_orthology)	RAD50 MET	3.18e-03	25	99	2	DOID:1612 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
FCVKKGEILGLLGPN	ABCA5	1321	Q8WWZ7
IICGLIKGGAAKLQI	NT5C3A	71	Q9H0P0
GGHGALICALKNPGK	ESD	151	P10768
ICGAGEELKGNKVPE	MS4A2	201	Q01362
VGQKAPLVGLGGLKA	BAHCC1	646	Q9P281
PLVGLGGLKASCIQQ	BAHCC1	651	Q9P281
CKAIAANSELVKPGG	DISP3	1056	Q9P2K9
GPCPNLKETGVEKAG	CRYBB2	36	P43320
GSFCPGGSIKQIQVK	CDCP1	496	Q9H5V8
VAAQNGILIKGGKPL	ATP7B	1001	P35670
LQEGGGSCLFNKPLK	ADAM11	426	O75078
VNLEGLGGKLKGPDV	AHNAK	671	Q09666
ALCGKLQCQGGKPSL	ADAM33	571	Q9BZ11
LGIPGEKGKAGTVCD	COLEC10	106	Q9Y6Z7
EAIKGLNGQKPLGAA	ELAVL3	181	Q14576
CDECVPLIKGAGIKQ	CDADC1	426	Q9BWV3
AVVCKQLGCGKPLHV	CD163L1	511	Q9NR16
APGALGQVKAKVEVC	DGCR8	416	Q8WYQ5
GAGNPKCKIAIVLGR	ACAD11	541	Q709F0
GNADDLKKLGIPVVC	CHDH	311	Q8NE62
VLFQGKIGLPILCVG	NAGK	256	Q9UJ70
QKLGCGKLTGVSNPI	OLFM2	191	O95897
KIVLIGNAGVGKTCL	RAB30	11	Q15771
GPNGAGKTTIIECLK	RAD50	36	Q92878
IIEGKGLISKQPGTC	RGS3	156	P49796
KPGEGKLIFCSGLVL	NR4A1	456	P22736
VGKGAVQLLPGAVCV	AOC2	411	O75106
EILGAVCLVPGGHKK	DAAM2	221	Q86T65
GPELSKGQLCGVVLD	MDN1	4336	Q9NU22
KGLKPGGIYVVCVVA	LRRN4CL	141	Q8ND94
SPNPKCGKNGVGVLI	LYVE1	101	Q9Y5Y7
LQSPCIIEGESGKGK	NLRC4	161	Q9NPP4
KGGLLCTLQGKLQPE	GPAA1	261	O43292
KGKICLPADCTVGGI	MGA	61	Q8IWI9
GILKNGLICDFKFGP	GPBP1	431	Q86WP2
GGIEGAKVKVPTPCE	HERC2	3966	O95714
KICLKASLKGVPGFG	LCLAT1	146	Q6UWP7
CGSEGLLKAIGIPEQ	C9orf131	141	Q5VYM1
GAIPIVCKDIALGLG	ENDOD1	446	O94919
PKGGGNAVKVRHILC	PIN4	31	Q9Y237
VGLICKNEDQKPGGV	MUC2	1846	Q02817
IKEVQKGGPADLAGL	PDZK1P1	286	A8MUH7
VPADKCGLVIGKGGE	FUBP3	361	Q96I24
CGLVIGKGGENIKSI	FUBP3	366	Q96I24
KAIQKVVADGAGLPG	GFUS	21	Q13630
CVAGKDLPEGAVKGL	GCN1	36	Q92616
AELKLGFIAQGCLVP	KCNU1	476	A8MYU2
PEELGNCGGLKKAGL	LRRC8E	761	Q6NSJ5
GVGGIRLPNGKLKCD	IKZF1	106	Q13422
KEPAKLCGAAGGLEN	IRS1	1161	P35568
GEGGIRLPNGKLKCD	IKZF2	101	Q9UKS7
VCLPAAGQALVDGKI	HPN	276	P05981
GKKQLPDCIVGEDGL	SMPD4	691	Q9NXE4
EPLGGNAILNCEVKG	HMCN1	4361	Q96RW7
GVCGACKKPIAGQVV	PXN	356	P49023
ILGAVCLVPGGHKKV	DAAM1	226	Q9Y4D1
AKCILAGDPAVGKTA	IFT27	6	Q9BW83
APKVLCAVGGKSGLF	KLHL28	281	Q9NXS3
QINLLGEGGICKLPG	ETV7	31	Q9Y603
GLKNGVPAVGLKLND	COPA	991	P53621
GLTHKQAVQCLKGPG	FRMPD2B	21	Q6IN97
EGKNIIICLPTGSGK	IFIH1	321	Q9BYX4
QILVPGLKGDAGEKG	COLEC11	36	Q9BWP8
IGCKDPAQGQLLKEL	GPD1	166	P21695
GPLLVCKKGVLNADG	HEPHL1	556	Q6MZM0
QKGGIPNVEGAAKLL	GNL3	376	Q9BVP2
LAVCKAGAAEKGVPL	ENO3	116	P13929
EKVIPALACLGQGKG	SLC12A8	341	A0AV02
GQGKGPNKTPVAAIC	SLC12A8	351	A0AV02
CLGGELLLQGPVFIK	CNTN3	16	Q9P232
GIRLPNGKLKCDVCG	IKZF4	151	Q9H2S9
GVPGKKCGTIILSAE	CPNE5	156	Q9HCH3
KEPGLGQLCFKQLGE	MAP3K14	201	Q99558
EDQPLGLKGGKKGEC	MN1	1171	Q10571
LIKGGGGCLTQEKIV	RPIA	171	P49247
TGKKITKIPLNGLGC	MET	506	P08581
RKIPGDKCQGGVNPV	SORT1	716	Q99523
GAPQKLCLGLGAKAM	PLEKHH3	676	Q7Z736
QKKKAGPGSLELCGL	RRP1B	571	Q14684
LGLDAGKIKQVGIIC	TAB1	221	Q15750
RPDLKLKCGACGAIG	TAF1L	1276	Q8IZX4
ELGLVISGAKEGPCL	NBEA	2791	Q8NFP9
LEKLKVGQGCATPLA	PRORSD1P	96	A6NEY8
AGKLGDPACPEIKIQ	RAP1GAP	636	P47736
FQLPLKKCAVVGNGG	ST8SIA1	131	Q92185
EKIVAAGCIPLTLGG	AGMAT	146	Q9BSE5
KGACGLQTKIQGPRG	VMO1	171	Q7Z5L0
SGCPLNAQVIKKGKV	ST18	891	O60284
SAKLGPVGGICGQKQ	LINC00615	26	Q96LM1
KGVECDGSKKILPLG	ZIM3	116	Q96PE6
KQCILLLEGGPFSGL	ZSWIM5	711	Q9P217
GCKQNGTKLGDVILP	WDFY3	2866	Q8IZQ1
GCEGGTDVKGKILPK	XAGE2	81	Q96GT9
LCLNNDTKEGKPGVG	SLC7A1	231	P30825
LLLGGVNKIAEKICG	SPINT4	21	Q6UDR6
KRLIAGCIGKPLGEQ	XPO5	1151	Q9HAV4
LGAALAGPVLGLKEC	PSAP	11	P07602
CILDGGINKIKPTGL	TBCK	871	Q8TEA7
LCLLGAGPVKAGVTQ	TRBV5-1	11	A0A578
LLPGGGVSCKLAIQI	SP140	216	Q13342
RTCPKGLNPGKAIAE	SDHB	251	P21912
VVNLLGACTKQGGPL	FLT1	891	P17948
VAGAKVAKGQPLCVL	PC	1126	P11498
PVCAKGFGQGSALLK	ZNF358	266	Q9NW07
KRGCKGLVKVGAPGI	KIAA2013	436	Q8IYS2