Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainCUB

C1S ADAMTS13

5.47e-0353392PS01180
DomainCUB_dom

C1S ADAMTS13

6.31e-0357392IPR000859
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_REST_MEDIATED_TRANSCRIPTIONAL_REPRESSION

RCOR1 SIN3A

9.13e-057302M47673
Pubmed

POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer.

POTEB3 POTEC POTED

8.48e-08841312475935
Pubmed

The composition and signaling of the IL-35 receptor are unconventional.

RAG1 IL6ST STAT4

1.27e-07941322306691
Pubmed

STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE.

RAG1 STAT4

1.36e-06241226123499
Pubmed

T-bet dependent removal of Sin3A-histone deacetylase complexes at the Ifng locus drives Th1 differentiation.

SIN3A STAT4

4.06e-06341219050254
Pubmed

Early-life infection depletes preleukemic cells in a mouse model of hyperdiploid B-cell acute lymphoblastic leukemia.

RAG1 STAT4

4.06e-06341238875504
Pubmed

Interferon-β suppresses murine Th1 cell function in the absence of antigen-presenting cells.

RAG1 STAT4

4.06e-06341225885435
Pubmed

The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex.

RCOR1 SIN3A

8.12e-06441210734093
Pubmed

Cerebrospinal fluid proteomic analysis reveals dysregulation of methionine aminopeptidase-2 expression in human and mouse neurofibromatosis 1-associated glioma.

NF1 METAP2

8.12e-06441216267007
Pubmed

Intradermal cytosine-phosphate-guanosine treatment reduces lung inflammation but induces IFN-γ-mediated airway hyperreactivity in a murine model of natural rubber latex allergy.

RAG1 STAT4

8.12e-06441220581096
Pubmed

STAT4 Directs a Protective Innate Lymphoid Cell Response to Gastrointestinal Infection.

RAG1 STAT4

1.35e-05541231562212
Pubmed

Interferon-β acts directly on T cells to prolong allograft survival by enhancing regulatory T cell induction through Foxp3 acetylation.

RAG1 STAT4

1.35e-05541235148827
Pubmed

SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation.

RNF7 NF1

2.03e-05641222118770
Pubmed

Critical and independent role for SOCS3 in either myeloid or T cells in resistance to Mycobacterium tuberculosis.

RAG1 IL6ST

2.03e-05641223853585
Pubmed

Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths.

POTEB3 POTED

2.84e-05741215276201
Pubmed

Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.

RCOR1 SIN3A

2.84e-05741217956988
Pubmed

Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation.

RCOR1 SIN3A

2.84e-05741211602581
Pubmed

ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.

RCC1 RCOR1 SIN3A KANSL1

2.97e-0515041428242625
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

RCC1 RCOR1 KIF2A SIN3A PRKRIP1 EDC4 RAD54L2 METAP2

3.76e-05110341834189442
Pubmed

ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation.

RNF7 KIF2A

3.78e-05841227697924
Pubmed

CoREST is an integral component of the CoREST- human histone deacetylase complex.

RCOR1 SIN3A

3.78e-05841211171972
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

RCC1 KIF2A SIN3A EDC4 RAD54L2

4.35e-0533241532786267
Pubmed

Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis.

RAG1 STAT4

4.86e-05941226038559
Pubmed

JAK-STAT and bone metabolism.

IL6ST STAT4

6.07e-051041224069548
Pubmed

Reconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: identification of the active components and JAK2 and gp130 as substrates.

RNF7 IL6ST

7.41e-051141224438103
Pubmed

Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation.

RAG1 STAT4

8.88e-051241230759395
Pubmed

Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations.

EID3 PDZD2

8.88e-051241224528284
Pubmed

The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration.

RAG1 RCC1 SIN3A PIGG

8.92e-0519941436688959
Pubmed

Murine models of Pneumocystis infection recapitulate human primary immune disorders.

RAG1 STAT4

1.05e-041341229925696
Pubmed

A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.

RCC1 KIF2A EID3 CPLANE1 GRAP2

1.48e-0443141533660365
Pubmed

Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1.

RCOR1 SIN3A

1.61e-041641211102443
Pubmed

A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.

RCOR1 SIN3A

2.05e-041841212493763
Pubmed

FOXK2 Elicits Massive Transcription Repression and Suppresses the Hypoxic Response and Breast Cancer Carcinogenesis.

RCOR1 SIN3A

2.54e-042041227773593
Pubmed

Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells.

RCOR1 SIN3A

3.38e-042341221670149
Pubmed

Protein interactome reveals converging molecular pathways among autism disorders.

SIN3A NF1 EDC4 RAD54L2 CPLANE1

4.94e-0456041521653829
Pubmed

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.

NF1 METAP2 C4orf54 GRAP2

6.18e-0433141419490893
Pubmed

Interaction proteomics of the HMGA chromatin architectural factors.

RCC1 METAP2

6.58e-043241218850631
Pubmed

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.

IL6ST STAT4

8.80e-043741220453842
Pubmed

Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.

RCOR1 SIN3A

9.28e-043841233283408
InteractionPOTED interactions

POTEB3 POTEC POTED

3.12e-084413int:POTED
InteractionPOTEC interactions

POTEB3 POTEC POTED

2.20e-0613413int:POTEC
InteractionPOTEB3 interactions

POTEB3 POTEC POTED

4.89e-0535413int:POTEB3
GeneFamilyAnkyrin repeat domain containing|POTE ankyrin domain containing

POTEC POTED

1.92e-0413292685
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

KIF2A PRKRIP1 ZNF385C STAT4 PDZD2

4.73e-0716941501a24a8817628125bd004b2be68ffa62c7111f6e
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

RCOR1 NF1 KANSL1 IL6ST STAT4

8.01e-07188415ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

KIF2A TNRC6C IL6ST STAT4 GRAP2

8.22e-071894159ab77c6fcb573854da5922412f53d2168bda6b58
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

KIF2A TNRC6C IL6ST STAT4 GRAP2

8.22e-071894155a9e2ca9a9ee2dc37ab9147a902115a9f1a80169
ToppCellMS-CD8-antiviral_CD4|MS / Condition, Cell_class and T cell subcluster

SYT15 RCC1 RAD54L2 ZNF385C EID3

8.44e-071904158c831c4560b8e70f92b4c15644fea39f7f7afcf2
ToppCellE18.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ALPK2 STAT4 GRAP2 MYO1F

1.41e-051604144a0ae0a83a10dbfc13591f4d2228ba8bcd2c2275
ToppCellfacs-GAT-Fat-3m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAG1 PPM1H STAT4 GRAP2

1.63e-051664143695407e4638f3c18fbff63daba52baa9256c429
ToppCell3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GMPR GPC6 SC5D PPM1H

1.67e-0516741449d9220f22d10ff06c0512c9c40c26ad51728e4f
ToppCell3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GMPR GPC6 SC5D PPM1H

1.67e-051674147ec032a98a13504d15c7e3a4e259278d07f40180
ToppCell3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GMPR GPC6 SC5D PPM1H

1.67e-051674145e3588eee73693a996bb4846427cf0038ceafbca
ToppCellfacs-Aorta-Heart-24m-Myeloid-macrophage|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RCC1 EID3 GRAP2 MYO1F

1.91e-05173414d0d1c8bcef3d9c28ee9a7c64076624b836cb2580
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

TNRC6C IL6ST STAT4 GRAP2

2.38e-05183414f2ef110bf29b1a8276ef216238363e542db262c1
ToppCelldroplet-Tongue-nan-24m-Myeloid-Langerhans_cell|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ALPK2 STAT4 GRAP2 MYO1F

2.54e-051864143e16781b9646de971d953da2c49d4210a4c23fe3
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c05-FOS|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

TNRC6C IL6ST STAT4 GRAP2

2.54e-05186414c793a3d5709ad504c12fc3b2337746d90236d3ca
ToppCelldroplet-Tongue-nan-24m-Myeloid|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ALPK2 STAT4 GRAP2 MYO1F

2.54e-05186414298ea4c7f61df65537dfef171ca81d4e976d89c5
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

KIF2A IL6ST STAT4 GRAP2

2.71e-05189414e9df7ecd36bee1fedce23bb188c68a94fa60462c
ToppCell3'-GW_trimst-1-SmallIntestine-Hematopoietic-T_cells-LTi-like_NCR-_ILC3|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNF385C STAT4 GRAP2 MYO1F

2.76e-05190414af39d2a46d9502cec69a69b7e8ffef78fc8311c3
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

KIF2A TNRC6C IL6ST STAT4

2.82e-05191414696921a4f160b6b55698652488ed781e855e5e51
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

KIF2A TNRC6C IL6ST STAT4

2.82e-05191414d9a6f61fcda4f5352488f7f55cb9b57aeacc717f
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

IVNS1ABP KANSL1 IL6ST STAT4

2.88e-0519241447646d7e4990be85072987f92bf18d52f8da752e
ToppCelldroplet-Thymus-nan-18m|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAG1 KIF2A METAP2 PPM1H

2.94e-0519341481871f4f2b63ca5f64a9ff12f6c909a34bf52216
ToppCelldroplet-Thymus-nan-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAG1 KIF2A METAP2 PPM1H

2.94e-0519341412380713db6582749183a19de65d4af9d6469a3f
ToppCell3'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-LTi-like_NCR-_ILC3|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNF385C STAT4 GRAP2 MYO1F

2.94e-05193414d8e6a7f1da4506acaa06380b4aec3fe299ec8b7e
ToppCellRA-03._Atrial_Cardiomyocyte|RA / Chamber and Cluster_Paper

AKAP6 ALPK2 STAT4 PDZD2

3.00e-05194414c3535f7cc0076653c72db582047cff053c322397
ToppCellInfluenza_Severe-CD8+_Tem|Influenza_Severe / Disease group and Cell class

KIF2A TNRC6C STAT4 GRAP2

3.12e-05196414c2d31b2a560309264e846271430a846f09a73ef8
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

KIF2A TNRC6C STAT4 GRAP2

3.12e-05196414c4e7133c609bcbc48c4947ea0aa1a7d9d7251b04
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

KIF2A TNRC6C STAT4 GRAP2

3.18e-0519741459b1fb93a39dcf8c994d2b7dc2906dae74c57527
ToppCell368C-Lymphocytic-CD4_T-cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

KIF2A STAT4 GRAP2 MYO1F

3.18e-0519741411762042f9ee8d02af432ccffe1c05aee9cb11ea
ToppCellsevere_influenza-CD8+_Tem|severe_influenza / disease group, cell group and cell class (v2)

KIF2A TNRC6C STAT4 GRAP2

3.24e-0519841419d9516a04b75e2c8b6b66b5af25b319b0641ac9
ToppCellTracheal-10x3prime_v2-Immune_Lymphocytic-T-T_CD8-CD8_CTL|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

ALPK2 STAT4 GRAP2 MYO1F

3.31e-051994147c63c389c914f1ef2fa92fa153f9ecf1087b8e31
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

KIF2A TNRC6C STAT4 GRAP2

3.31e-05199414accfdf22a2c9e9b926b8328efdadd24979477edf
ToppCellSepsis-Leuk-UTI-Lymphocyte-T/NK-CD4+_Tem|Leuk-UTI / Disease, condition lineage and cell class

KIF2A TNRC6C STAT4 GRAP2

3.37e-0520041465ea3ba16c75f8e9a5aee3ba0c7ab11a961fff7c
ToppCellInfluenza-Influenza_Severe-Lymphocyte-T/NK-CD8+_Tem|Influenza_Severe / Disease, condition lineage and cell class

KIF2A TNRC6C STAT4 GRAP2

3.37e-0520041406d80a7aff4b168b131c80750c335215b0fcff3f
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_ALM_Ptrf|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADAMTS13 PDYN STAT4

2.48e-04133413a1bc34e5dda4ff4716b857931cc196f6770f58f4
ToppCellPBMC-Severe-cDC_8|Severe / Compartment, Disease Groups and Clusters

SYT15 C1S EID3

3.19e-0414541323a9a4fd1934c4a38d9259105c1fdbac459575cb
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c07-AHNAK|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

KIF2A EID3 STAT4

3.33e-041474135e6dd2ddc67b3722f6528e7277cbc7f296098687
ToppCellControl-Lymphocytic_NKT-iNKT/MAIT-T-cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ALPK2 STAT4 MYO1F

3.39e-04148413003e10bf477984248211b99d75daa8f7dcdb12c8
ToppCellHealthy_donor-RBC|World / disease group, cell group and cell class (v2)

C1S GMPR ADAMTS13

3.53e-041504131e1a497ec4b048f7e9cc12dd5dd9aba7fedca9e1
ToppCell368C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell|368C / Donor, Lineage, Cell class and subclass (all cells)

SC5D STAT4 GRAP2

3.60e-0415141372c47ed207951e73ef6c72085b2a3f48a99be952
ToppCellLPS-IL1RA+antiTNF-Hematopoietic_Meg-Ery-Platelets-Platelets|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GMPR KIF2A GRAP2

3.67e-04152413aff7d1127ef72be489477611c4decc53cc7632e3
ToppCellLPS-IL1RA+antiTNF-Hematopoietic_Meg-Ery-Platelets|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GMPR KIF2A GRAP2

3.67e-041524130a99c91165e4d82fb8825fbdf3071c9a5445669d
ToppCellfacs-Aorta-Heart-24m-Myeloid-nan|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EID3 STAT4 GRAP2

3.67e-04152413525d65c5c8e5580947367afdb1f6e68b49e9e5bb
ToppCellRV-17._Lymphocyte|RV / Chamber and Cluster_Paper

STAT4 GRAP2 MYO1F

3.74e-04153413e1ea621184014415870e00d511386b8cc3e0833b
ToppCellP28-Hematopoietic|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

STAT4 GRAP2 MYO1F

3.81e-0415441313980ae1957b05350c11171c9c118decfe998d3d
ToppCellHealthy_donor-RBC|Healthy_donor / disease group, cell group and cell class (v2)

C1S GMPR ADAMTS13

3.81e-04154413e080d5104fe6f3f6ef617bbcdccf1332ab7231e1
ToppCellAdult-Immune-enucleated_erythrocyte|Adult / Lineage, Cell type, age group and donor

GMPR EDC4 ALPK2

3.88e-04155413e2d07ee4348d2c1d3552a8d0337ea42777c31f9c
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8|bone_marrow / Manually curated celltypes from each tissue

KANSL1 IL6ST STAT4

3.96e-041564131545169694f686d28648a68b552c2ae606599d66
ToppCellT_cells-GNLY+GZMB+_T_cells|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

STAT4 GRAP2 MYO1F

4.03e-04157413e9eb56a1dd96bd2e9725a20f2cf70ddeab811bd6
ToppCellP28-Hematopoietic-Immune-immune_cell_unspecified|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

STAT4 GRAP2 MYO1F

4.03e-04157413a70f93aff07b6b7a9efce33b12b024116648dc0a
ToppCellP28-Hematopoietic-Immune|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

STAT4 GRAP2 MYO1F

4.03e-04157413b1f520b1e0ea7abb19d0dd27021eafbea0fd90cd
ToppCellHealthy/Control-RBC|Healthy/Control / Disease group and Cell class

C1S GMPR ADAMTS13

4.11e-041584131fec4f9affdbfba2e281183b717d4d357d474400
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PIGG CDH8 GRAP2

4.18e-041594132233fee5dcdb6c7dee5b1bd8efbc07d86b339927
ToppCellHealthy/Control-RBC|World / Disease group and Cell class

C1S GMPR ADAMTS13

4.26e-04160413f10871238e7bdf3e1f65a17070000477196e50fe
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma|TCGA-Brain / Sample_Type by Project: Shred V9

AKAP6 TNRC6C SAMD8

4.34e-04161413347edb0de10850b7d16c40945751033289289c9b
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

STAT4 GRAP2 MYO1F

4.58e-04164413649e42d9cfdec2f7771d1e938b516e46e7d07078
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

STAT4 GRAP2 MYO1F

4.58e-04164413ba85f7b21ae34e285d286ada24715885ca6329f7
ToppCell5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

C1S GPC6 PDZD2

4.58e-04164413a764b79a127c8f360af0b79a1da64658badf0dfa
ToppCellLeuk-UTI-Lymphocyte-T_NK-CD4_TEM|Leuk-UTI / Disease, Lineage and Cell Type

TNRC6C STAT4 GRAP2

4.66e-0416541308285c09de16ed4f488abb655a22f54bc07968ae
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-T_cells-Th1|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

STAT4 GRAP2 MYO1F

4.83e-041674139c55ec8f70b86d4d3d5c2a6ecd9bff2dafe68c11
ToppCelldroplet-Bladder-nan-24m-Hematologic-granulocyte-monocyte_progenitor|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAT4 GRAP2 MYO1F

4.91e-04168413c6e0daa790dd5db20dd1ab8c1e7142484976d743
ToppCelldroplet-Lung-3m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l4|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

STAT4 GRAP2 MYO1F

4.91e-0416841319d2c763b50e7168dfa7449fc407489b055526c2
ToppCelldroplet-Lung-3m-Hematologic-lymphocytic-mature_NK_T_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

STAT4 GRAP2 MYO1F

4.91e-04168413fa198bd53b2d640d9a8684783bf5ca23314caae2
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Lymphocytic-NK_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPM1H STAT4 MYO1F

5.00e-041694138028622ff362d70d1002e65a74ade46ea7f1f13f
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

C1S GPC6 IL6ST

5.00e-04169413c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCellwk_15-18-Hematologic-Meg-ery-Megakaryocyte|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

GMPR KIF2A GRAP2

5.00e-04169413d571e84e01e3316748d4407ed98881b17484e035
ToppCellfacs-MAT-Fat-24m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPM1H STAT4 GRAP2

5.00e-041694133a18b4ad826e6ab9cbfd1d51a23a1b67c9a08596
ToppCellCOVID-19-Heart-CM_+_Macrophage|COVID-19 / Disease (COVID-19 only), tissue and cell type

AKAP6 C4orf54 ALPK2

5.08e-041704133f15242a1d3e4e9871d9170b2ef05842fb609c29
ToppCelldroplet-Liver-LIVER-NPC-1m-Lymphocytic-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNRC6C STAT4 GRAP2

5.08e-041704133ad9f950b87ee98f025ab9b4a8ed551e6a9b4764
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

KANSL1 IL6ST STAT4

5.17e-041714132e9a20f8980b78325c52065a9c14ab3656267c05
ToppCellImmune_cells-pro-B|Immune_cells / Lineage and Cell class

RAG1 GMPR PDZD2

5.26e-04172413096636f2589fa56d15942aac96641c16fd5fa78d
ToppCellIIH-CD8-CD8_2|IIH / Condition, Cell_class and T cell subcluster

TNRC6C STAT4 GRAP2

5.26e-041724131466cb4298c63e995b3368d296b254e0e76a1b41
ToppCellcellseq-Immune-Hematopoietic-Megakaryocyte/Platelet|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GMPR KIF2A GRAP2

5.26e-04172413eb2915165cab2660511e4b70c3a6d3ab2f770809
ToppCellcellseq-Immune-Hematopoietic-Megakaryocyte/Platelet-Megakaryocyte/Platelet|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GMPR KIF2A GRAP2

5.26e-04172413d0c3fb48c61762dcefca858cf13c9da8eb6d0f5e
ToppCellImmune-mast_cell|World / Lineage, Cell type, age group and donor

GMPR PPM1H GRAP2

5.26e-041724136e8e0aac5a20dbc789bf8c6916833bb8709a411a
ToppCellwk_15-18-Hematologic-Myeloid-Mast|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

GMPR PPM1H GRAP2

5.26e-04172413a7146c255031207e64682ef767884b11c96e0d59
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Myeloid-cDC1|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AKAP6 PPM1H MYO1F

5.35e-04173413d13ae4046a25ee0fb492ddedf44583a879a432e9
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-T_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

STAT4 GRAP2 MYO1F

5.44e-0417441347e308a777c927ae69ed344cb3dd8561bf2c48a5
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-T_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

STAT4 GRAP2 MYO1F

5.44e-04174413a92c745d20633909db0f08effa13fc738fda79a6
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STAT4 GRAP2 MYO1F

5.53e-04175413da92eb8af0c7c65fed4a1d960708240f35dd997d
ToppCell343B-Lymphocytic-NK_cells-NK_cell_B1|343B / Donor, Lineage, Cell class and subclass (all cells)

STAT4 GRAP2 MYO1F

5.53e-04175413b1003230c39b2a9ceb43cb80728061d906ed0835
ToppCellfacs-BAT-Fat-18m-Lymphocytic-T_cell|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPM1H STAT4 GRAP2

5.53e-04175413bf1ef77d5fed2135ac83a4f7e445ab59d1538696
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STAT4 GRAP2 MYO1F

5.53e-041754132f43883d7c89f09b0579a390a7431f1f9b832582
ToppCellfacs-Spleen-nan-18m-Lymphocytic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPM1H STAT4 MYO1F

5.62e-04176413a23d484aff5ad094333b2feae9106ca219514711
ToppCellfacs-MAT-Fat-3m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPM1H STAT4 GRAP2

5.62e-0417641377c6103639acd0f3d6a2171c5f37a8083b6c2cf0
ToppCellCOVID-19-Heart-CM_3|COVID-19 / Disease (COVID-19 only), tissue and cell type

AKAP6 C4orf54 ALPK2

5.62e-041764139df7a124ebafb0087da0cda133a394275d7bed81
ToppCell3'-GW_trimst-1-SmallIntestine-Hematopoietic-T_cells-ILC2|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

STAT4 GRAP2 MYO1F

5.72e-041774139828504591599619649d41a78daf7c052729c669
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma|TCGA-Brain / Sample_Type by Project: Shred V9

AKAP6 TNRC6C SAMD8

5.72e-04177413e8ab340b20cd41554c3841fe980e078e878af35f
ToppCellfacs-GAT-Fat-18m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPM1H STAT4 GRAP2

5.81e-0417841344634ba10da34307d6217646b221ddf5d7a65fb0
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GPC6 CDH8 PDYN

5.81e-04178413b863fc85d2449f25e6cea289459a7bb1f89583fd
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Pdyn_(Neuron.Gad1Gad2.Sst-Pdyn)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

ALPK2 PDYN

5.88e-0439412a24eb4c26344c5c97bbf39a1adc56ee34013dc4f
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Pdyn_(Neuron.Gad1Gad2.Sst-Pdyn)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

ALPK2 PDYN

5.88e-04394128b5d15f979a92799a9e77f1b501d3c4fa4e8695a
ToppCellfacs-Diaphragm-Limb_Muscle-3m-Lymphocytic-T_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAG1 STAT4 GRAP2

5.91e-041794138bf04a7ad1b0be6722ebfdceba3f083f07bf96c5
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-T_cells-Th17|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

STAT4 GRAP2 MYO1F

5.91e-0417941361472d75f4a3c4374eeb55ef79982ae4054dadaa
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

STAT4 GRAP2 MYO1F

5.91e-04179413874a9afa91774221c9c1775aa4968ba0aea7b554
ToppCellmetastatic_Lymph_Node-T/NK_cells-Naive_CD8+_T|metastatic_Lymph_Node / Location, Cell class and cell subclass

STAT4 GRAP2 MYO1F

6.00e-0418041316516dd9c78c27fc76f58d650de9851ffa0763e7
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-mLTo|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

C1S IL6ST ALPK2

6.00e-04180413f103e161e966c257eac97e1b30a461c4ed9cafc2
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Myeloid-Mast_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GMPR PPM1H GRAP2

6.00e-041804132658a6be43d6d94767b4fc5af2d8632469a8a979
ToppCelldroplet-Kidney-nan-18m-Epithelial-Stroma____kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 C1S GPC6

6.00e-04180413b6f44fdedc33b7d93b0074e8e9c8cc32009d4c4d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STAT4 GRAP2 MYO1F

6.00e-04180413c62417f205bcbf3b212ae177f63562ec6467c855
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STAT4 GRAP2 MYO1F

6.00e-04180413bb2dbf7ed03d5ac765635b7afe738efa822841d0
DrugKetanserin tartrate hydrate [83846-83-7]; Down 200; 7uM; PC3; HT_HG-U133A

RCC1 NF1 RAD54L2 CPLANE1 METAP2

1.71e-051893956649_DN
DrugPiromidic acid [19562-30-2]; Down 200; 13.8uM; MCF7; HT_HG-U133A

RCC1 KIF2A NF1 RAD54L2 IL6ST

1.99e-051953954398_DN
DrugMorantel tartrate [26155-31-7]; Up 200; 10.8uM; MCF7; HT_HG-U133A

RCC1 NF1 RAD54L2 IL6ST MYO1F

2.09e-051973951676_UP
DrugBemegride [64-65-3]; Down 200; 25.8uM; PC3; HT_HG-U133A

GMPR NF1 CPLANE1 IL6ST MYO1F

2.14e-051983956668_DN
DiseaseMental Retardation, Psychosocial

SIN3A NF1 KANSL1 SC5D

2.76e-05139374C0025363
DiseaseProfound Mental Retardation

SIN3A NF1 KANSL1 SC5D

2.76e-05139374C0020796
DiseaseMental deficiency

SIN3A NF1 KANSL1 SC5D

2.76e-05139374C0917816
DiseaseIntellectual Disability

AKAP6 SIN3A NF1 KANSL1 SC5D

2.28e-04447375C3714756
Diseasebitter alcoholic beverage consumption measurement

NF1 GPC6 CDH8

6.22e-04133373EFO_0010092
DiseaseSevere Congenital Microcephaly

KIF2A SIN3A

6.95e-0431372C3853041
DiseaseMicrolissencephaly

KIF2A SIN3A

7.88e-0433372C1956147
Diseasemultiple sclerosis

RCOR1 KANSL1 ALPK2 STAT4 GRAP2

8.32e-04594375MONDO_0005301
DiseaseCraniofacial Abnormalities

SIN3A KANSL1 GPC6

9.87e-04156373C0376634

Protein segments in the cluster

PeptideGeneStartEntry
VGSSMSGEGRSEKGH

ZNF385C

206

Q66K41
HFLSGMGCGSRVSGD

ALPK2

376

Q86TB3
MVEQPKGCGGGTHSS

CFAP418

26

Q96NL8
EGMCGTEHAQLGEDG

RAD54L2

51

Q9Y4B4
GCGPSGHVMASDGAA

ADAMTS13

241

Q76LX8
HSGSSGSKSGGDKMF

RNF7

16

Q9UBF6
SCDGMGDVSEKHGSG

RAG1

601

P15918
SSGSSSDEEHGGGGM

RCOR1

91

Q9UKL0
GGQHHTVCMDSEGKA

RCC1

301

P18754
SLGADGTHGAGAMES

EDC4

486

Q6P2E9
FGSTGKGVVHDDMEC

METAP2

366

P50579
GGSNGHSDDLSCGEM

IVNS1ABP

421

Q9Y6Y0
MGEGNDSSCHGRKQG

EID3

291

Q8N140
SSEVAGEGDGDSMGH

PDYN

186

P01213
MVAGSEDEDHPGSGC

PDZD2

881

O15018
SALHGGEMGGSESGD

KANSL1

186

Q7Z3B3
DVMGSSAGAGSGEFH

PRKRIP1

66

Q9H875
RGSGKSNMGTSGDHD

POTEB3

36

A0JP26
GSGKTHTMGGDFSGK

KIF2A

316

O00139
TEGHSSGIGGSSCMS

IL6ST

721

P40189
ESSGSGSGSGCMDDV

GPC6

491

Q9Y625
GAAKSHFECGMVGGV

CPLANE1

916

Q9H799
GEKGMDSCKGDSGGA

C1S

621

P09871
AKDMGGHSGGLSGTT

CDH8

246

P55286
LGGMFSGHTECAGEV

GMPR

241

P36959
DGHCGTGLGSEMNAA

GRAP2

241

O75791
MSDAGGEGSVAGSKS

C4orf54

881

D6RIA3
KGSGKSNMGTSGDHD

POTEC

36

B2RU33
RGSGKSNMGTSGDHD

POTED

36

Q86YR6
PHTSSGGLGDACMVG

SYT15

111

Q9BQS2
GLAHCSVSGGDGKMD

TNRC6C

61

Q9HCJ0
SGFGMTLTGVHTCGD

SAMD8

281

Q96LT4
SMADASKHGGGTESL

SIN3A

451

Q96ST3
CHGGDMSQNSGSESG

AKAP6

1351

Q13023
IMAGSSGSEHGGGSC

PPM1H

16

Q9ULR3
EMKSSAGGKGNEGCH

STAT4

406

Q14765
AGGKGNEGCHMVTEE

STAT4

411

Q14765
MGGCVGAQHDSSGSL

UBTD2

1

Q8WUN7
GKGNSSMDSAAGCSG

NF1

661

P21359
VGVCSDGAASMTGKH

ZBED9

966

Q6R2W3
CGDHGMSETGSHGAS

PIGG

266

Q5H8A4
EMTEGKRSSHSGNGC

SC5D

271

O75845
LDDVCATMHATGGGA

MYO1F

461

O00160