Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	low voltage-gated calcium channel activity	CACNA1I CACNA1H CACNA1G	9.16e-08	3	91	3	GO:0008332
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1C CACNA1I CACNA1H CACNA1G	3.90e-07	14	91	4	GO:0008331
GeneOntologyMolecularFunction	ubiquitin-like ligase-substrate adaptor activity	PRAMEF7 FZR1 PRAMEF9 PRAMEF15 PRAMEF8 PRAMEF11	2.01e-06	82	91	6	GO:1990756
GeneOntologyMolecularFunction	enzyme-substrate adaptor activity	PRAMEF7 FZR1 PRAMEF9 PRAMEF15 PRAMEF8 PRAMEF11	4.76e-06	95	91	6	GO:0140767
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	NALCN CACNA1I CACNA1H CACNA1G	5.59e-06	26	91	4	GO:0005248
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1C CACNA1I CACNA1H CACNA1G	5.69e-05	46	91	4	GO:0005245
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in AV node cell action potential	CACNA1C CACNA1G	6.14e-05	3	91	2	GO:0086056
GeneOntologyMolecularFunction	sodium channel activity	NALCN CACNA1I CACNA1H CACNA1G	9.24e-05	52	91	4	GO:0005272
GeneOntologyMolecularFunction	nuclear retinoic acid receptor binding	PRAMEF7 PRAMEF15 PRAMEF8 PRAMEF11	1.15e-04	55	91	4	GO:0042974
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in cardiac muscle cell action potential	CACNA1C CACNA1G	2.04e-04	5	91	2	GO:0086007
GeneOntologyMolecularFunction	structural constituent of postsynaptic density	MPP2 DLG3	1.10e-03	11	91	2	GO:0098919
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	NALCN CACNA1I CACNA1H CACNA1G SLC38A3	1.12e-03	171	91	5	GO:0015081
GeneOntologyMolecularFunction	structural constituent of postsynaptic specialization	MPP2 DLG3	1.55e-03	13	91	2	GO:0098879
GeneOntologyBiologicalProcess	membrane depolarization during action potential	CACNA1C CACNA1I CACNA1H CACNA1G	1.87e-05	36	91	4	GO:0086010
GeneOntologyBiologicalProcess	calcium ion import across plasma membrane	CACNA1C CACNA1I CACNA1H CACNA1G	5.95e-05	48	91	4	GO:0098703
GeneOntologyBiologicalProcess	calcium ion import into cytosol	CACNA1C CACNA1I CACNA1H CACNA1G	5.95e-05	48	91	4	GO:1902656
GeneOntologyBiologicalProcess	positive regulation of calcium ion-dependent exocytosis	CACNA1I CACNA1H CACNA1G	8.97e-05	20	91	3	GO:0045956
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	PRAMEF7 PRAMEF9 PRAMEF15 PRAMEF8 PRAMEF11	1.86e-06	47	91	5	GO:0031462
GeneOntologyCellularComponent	voltage-gated calcium channel complex	CACNA1C CACNA1I CACNA1H CACNA1G	4.77e-05	46	91	4	GO:0005891
GeneOntologyCellularComponent	voltage-gated sodium channel complex	CACNA1I CACNA1H CACNA1G	5.19e-05	17	91	3	GO:0001518
GeneOntologyCellularComponent	sodium channel complex	CACNA1I CACNA1H CACNA1G	2.69e-04	29	91	3	GO:0034706
GeneOntologyCellularComponent	calcium channel complex	CACNA1C CACNA1I CACNA1H CACNA1G	2.91e-04	73	91	4	GO:0034704
GeneOntologyCellularComponent	dendritic shaft	MPP2 WHRN CACNA1C DLG3	3.06e-04	74	91	4	GO:0043198
GeneOntologyCellularComponent	cullin-RING ubiquitin ligase complex	PRAMEF7 FZR1 PRAMEF9 PRAMEF15 PRAMEF8 PRAMEF11	3.30e-04	212	91	6	GO:0031461
GeneOntologyCellularComponent	ubiquitin ligase complex	PRAMEF7 FZR1 PRAMEF9 PRAMEF15 ASB2 PRAMEF8 PRAMEF11	8.72e-04	352	91	7	GO:0000151
GeneOntologyCellularComponent	motile cilium	HSPD1 PRAMEF7 DNAH3 INTU PRAMEF15 PRAMEF8 PRAMEF11	9.16e-04	355	91	7	GO:0031514
MousePheno	abnormal jejunum morphology	PRAMEF7 PRAMEF15 PRAMEF8 PRAMEF11	4.53e-05	41	68	4	MP:0004002
MousePheno	abnormal learning/memory/conditioning	CACNA1C PRAMEF7 SERPINA3 FZR1 NTAN1 TCF20 PRAMEF15 DLG3 LSAMP B3GAT1 CACNA1G BRINP1 LRRN4 PRAMEF8 PTGER2 DDX24 PRAMEF11	6.61e-05	1239	68	17	MP:0002063
MousePheno	abnormal cognition	CACNA1C PRAMEF7 SERPINA3 FZR1 NTAN1 TCF20 PRAMEF15 DLG3 LSAMP B3GAT1 CACNA1G BRINP1 LRRN4 PRAMEF8 PTGER2 DDX24 PRAMEF11	7.09e-05	1246	68	17	MP:0014114
MousePheno	increased kidney weight	WHRN PRAMEF7 PRAMEF15 TMEM115 PRAMEF8 PRAMEF11	7.24e-05	145	68	6	MP:0003917
MousePheno	abnormal spermatogonia proliferation	PRAMEF7 PRAMEF15 PRAMEF8 PRAMEF11	7.80e-05	47	68	4	MP:0002685
Domain	VDCCAlpha1	CACNA1C CACNA1I CACNA1H CACNA1G	9.03e-08	10	87	4	IPR002077
Domain	VDCC_T_a1	CACNA1I CACNA1H CACNA1G	9.76e-08	3	87	3	IPR005445
Domain	PRAME_family	PRAMEF7 PRAMEF25 PRAMEF15 PRAMEF8	1.61e-06	19	87	4	IPR026271
Domain	Channel_four-helix_dom	CACNA1C NALCN CACNA1I CACNA1H CACNA1G	6.76e-06	57	87	5	IPR027359
Domain	-	CACNA1C NALCN CACNA1I CACNA1H CACNA1G	6.76e-06	57	87	5	1.20.120.350
Domain	Ion_trans_dom	CACNA1C NALCN CACNA1I CACNA1H CACNA1G	1.92e-04	114	87	5	IPR005821
Domain	Ion_trans	CACNA1C NALCN CACNA1I CACNA1H CACNA1G	1.92e-04	114	87	5	PF00520
Domain	NUT	NUTM2B NUTM2A	2.13e-04	5	87	2	IPR024310
Domain	NUT_N	NUTM2B NUTM2A	2.13e-04	5	87	2	IPR024309
Domain	NUT	NUTM2B NUTM2A	2.13e-04	5	87	2	PF12881
Domain	PDZ	MPP2 WHRN INTU DLG3 PARD3B	6.40e-04	148	87	5	SM00228
Domain	-	MPP2 WHRN INTU DLG3 PARD3B	6.80e-04	150	87	5	2.30.42.10
Domain	PDZ	MPP2 WHRN INTU DLG3 PARD3B	7.01e-04	151	87	5	PS50106
Domain	PDZ	MPP2 WHRN INTU DLG3 PARD3B	7.22e-04	152	87	5	IPR001478
Domain	Guanylate_kinase_CS	MPP2 DLG3	2.47e-03	16	87	2	IPR020590
Domain	Peptidase_S1_PA	KLK15 PAMR1 KLK9 COX15	2.62e-03	123	87	4	IPR009003
Domain	SOCS	SOCS1 ASB2	3.86e-03	20	87	2	SM00253
Domain	PDZ	MPP2 WHRN DLG3 PARD3B	4.27e-03	141	87	4	PF00595
Domain	ARM-type_fold	AP1G1 UBR4 TOGARAM2 DIAPH1 HUWE1 PPP4R4	5.04e-03	339	87	6	IPR016024
Domain	GUANYLATE_KINASE_2	MPP2 DLG3	5.09e-03	23	87	2	PS50052
Domain	GUANYLATE_KINASE_1	MPP2 DLG3	5.09e-03	23	87	2	PS00856
Domain	Guanylate_kin	MPP2 DLG3	6.48e-03	26	87	2	PF00625
Domain	GK/Ca_channel_bsu	MPP2 DLG3	6.48e-03	26	87	2	IPR008145
Domain	Guanylate_kin-like_dom	MPP2 DLG3	6.48e-03	26	87	2	IPR008144
Domain	GuKc	MPP2 DLG3	6.48e-03	26	87	2	SM00072
Pathway	KEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1C CACNA1I CACNA1H CACNA1G	3.41e-06	23	65	4	M47666
Pathway	KEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL	CACNA1C CACNA1I CACNA1H CACNA1G	4.84e-06	25	65	4	M47948
Pathway	REACTOME_NCAM1_INTERACTIONS	CACNA1C CACNA1I CACNA1H CACNA1G	4.04e-05	42	65	4	M7169
Pathway	REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH	CACNA1C CACNA1I CACNA1H CACNA1G	2.00e-04	63	65	4	M11187
Pubmed	Intracellular calcium plays an essential role in cardiac development.	CACNA1C CACNA1I CACNA1H CACNA1G	3.33e-09	8	93	4	12761855
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1C CACNA1I CACNA1H CACNA1G	5.97e-09	9	93	4	16382099
Pubmed	Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage.	CACNA1C CACNA1I CACNA1H CACNA1G	9.94e-09	10	93	4	24778262
Pubmed	Ethanol inhibition of a T-type Ca²+ channel through activity of protein kinase C.	CACNA1I CACNA1H CACNA1G	1.85e-08	3	93	3	23488970
Pubmed	T-type channels: release a brake, engage a gear.	CACNA1I CACNA1H CACNA1G	1.85e-08	3	93	3	26488564
Pubmed	Differential interactions of Na+ channel toxins with T-type Ca2+ channels.	CACNA1I CACNA1H CACNA1G	1.85e-08	3	93	3	18591418
Pubmed	Identification of the t-type calcium channel (Ca(v)3.1d) in developing mouse heart.	CACNA1I CACNA1H CACNA1G	1.85e-08	3	93	3	11230107
Pubmed	Prognostic relevance of a T-type calcium channels gene signature in solid tumours: A correlation ready for clinical validation.	CACNA1I CACNA1H CACNA1G	1.85e-08	3	93	3	28846697
Pubmed	Homeostatic plasticity and burst activity are mediated by hyperpolarization-activated cation currents and T-type calcium channels in neuronal cultures.	CACNA1I CACNA1H CACNA1G	1.85e-08	3	93	3	33547341
Pubmed	Calmodulin regulates Cav3 T-type channels at their gating brake.	CACNA1I CACNA1H CACNA1G	1.85e-08	3	93	3	28972185
Pubmed	Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability.	CACNA1I CACNA1H CACNA1G	1.85e-08	3	93	3	11927664
Pubmed	T-type, but not L-type, voltage-gated calcium channels are dispensable for lymphatic pacemaking and spontaneous contractions.	CACNA1C CACNA1H CACNA1G	1.85e-08	3	93	3	31919478
Pubmed	Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type calcium current transient expression during fetal development in mice.	CACNA1I CACNA1H CACNA1G	1.85e-08	3	93	3	11897840
Pubmed	Electric field stimulation unmasks a subtle role for T-type calcium channels in regulating lymphatic contraction.	CACNA1C CACNA1H CACNA1G	1.85e-08	3	93	3	37739992
Pubmed	LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.	MRPS18A PRAMEF7 PRAMEF15 PRAMEF8 PRAMEF11	2.33e-08	32	93	5	37889087
Pubmed	Pharmacogenetics of antiepileptic drug efficacy in childhood absence epilepsy.	CACNA1I CACNA1H CACNA1G	7.39e-08	4	93	3	28165634
Pubmed	Functional importance of L- and P/Q-type voltage-gated calcium channels in human renal vasculature.	CACNA1C CACNA1H CACNA1G	7.39e-08	4	93	3	21788606
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF7 PRAMEF15 PRAMEF8 PRAMEF11	1.11e-07	17	93	4	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF7 PRAMEF15 PRAMEF8 PRAMEF11	1.11e-07	17	93	4	37781892
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF7 PRAMEF15 PRAMEF8 PRAMEF11	1.42e-07	18	93	4	23894331
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF7 PRAMEF15 PRAMEF8 PRAMEF11	1.42e-07	18	93	4	12890732
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF7 PRAMEF15 PRAMEF8 PRAMEF11	1.42e-07	18	93	4	29731491
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF7 PRAMEF15 PRAMEF8 PRAMEF11	1.42e-07	18	93	4	14675769
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF7 PRAMEF15 PRAMEF8 PRAMEF11	1.42e-07	18	93	4	39181896
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF7 PRAMEF15 PRAMEF8 PRAMEF11	1.80e-07	19	93	4	28604677
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF7 PRAMEF15 PRAMEF8 PRAMEF11	2.25e-07	20	93	4	26694250
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF7 PRAMEF15 PRAMEF8 PRAMEF11	2.25e-07	20	93	4	16580637
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF7 PRAMEF15 PRAMEF8 PRAMEF11	2.25e-07	20	93	4	21425410
Pubmed	Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1.	SERPINA3 ASB2 DDX24 PPP4R4	2.77e-07	21	93	4	15014966
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF7 PRAMEF15 PRAMEF8 PRAMEF11	3.38e-07	22	93	4	31729367
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	PLEKHH1 DENND2A FZR1 INTU DLG3 GRID1	3.60e-07	103	93	6	10574462
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	PRAMEF7 PRAMEF15 PRAMEF8 PRAMEF11	4.08e-07	23	93	4	19480014
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF7 PRAMEF15 PRAMEF8 PRAMEF11	5.80e-07	25	93	4	37451217
Pubmed	Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.	PRAMEF7 PRAMEF15 PRAMEF8 PRAMEF11	5.80e-07	25	93	4	12620990
Pubmed	Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.	CACNA1C CACNA1H CACNA1G	6.43e-07	7	93	3	12900400
Pubmed	Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.	PRAMEF7 PRAMEF15 PRAMEF8 PRAMEF11	6.85e-07	26	93	4	18500982
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF7 PRAMEF15 PRAMEF8 PRAMEF11	9.34e-07	28	93	4	25089626
Pubmed	Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.	CACNA1I CACNA1H CACNA1G	1.03e-06	8	93	3	28330839
Pubmed	Neuroepithelial progenitors generate and propagate non-neuronal action potentials across the spinal cord.	CACNA1I CACNA1H CACNA1G	1.03e-06	8	93	3	34478646
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF7 PRAMEF15 PRAMEF8 PRAMEF11	1.24e-06	30	93	4	38786026
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PLEKHH1 WHRN INTU TCF20 RPAP1 ZBTB43 DLG3 CHPF2 CACNA1H	1.52e-06	407	93	9	12693553
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF7 PRAMEF15 PRAMEF8 PRAMEF11	2.35e-06	35	93	4	19389355
Pubmed	Suppressor of cytokine signaling 1 (SOCS1) limits NFkappaB signaling by decreasing p65 stability within the cell nucleus.	SOCS1 RELA	7.07e-06	2	93	2	21084693
Pubmed	A T-type calcium channel required for normal function of a mammalian mechanoreceptor.	CACNA1I CACNA1H	7.07e-06	2	93	2	12808460
Pubmed	Cav3.2 subunit underlies the functional T-type Ca2+ channel in murine hearts during the embryonic period.	CACNA1H CACNA1G	7.07e-06	2	93	2	14988077
Pubmed	Role of T-type calcium channel subunits in post-myocardial infarction remodelling probed with genetically engineered mice.	CACNA1H CACNA1G	7.07e-06	2	93	2	21622683
Pubmed	Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice.	CACNA1I CACNA1H	7.07e-06	2	93	2	25071191
Pubmed	Ca(v)3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain.	CACNA1H CACNA1G	7.07e-06	2	93	2	20685979
Pubmed	Chronic hypoxia selectively enhances L- and T-type voltage-dependent Ca2+ channel activity in pulmonary artery by upregulating Cav1.2 and Cav3.2.	CACNA1C CACNA1H	7.07e-06	2	93	2	23686856
Pubmed	Whole Exome Sequencing of Hemiplegic Migraine Patients Shows an Increased Burden of Missense Variants in CACNA1H and CACNA1I Genes.	CACNA1I CACNA1H	7.07e-06	2	93	2	36786913
Pubmed	Ca2+ influx through T- and L-type Ca2+ channels have different effects on myocyte contractility and induce unique cardiac phenotypes.	CACNA1C CACNA1H	7.07e-06	2	93	2	18832749
Pubmed	Contribution of postsynaptic T-type calcium channels to parallel fibre-Purkinje cell synaptic responses.	CACNA1I CACNA1G	7.07e-06	2	93	2	26627919
Pubmed	T-type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in the inhibition of proliferation and apoptosis in MCF-7 human breast cancer cells.	CACNA1H CACNA1G	7.07e-06	2	93	2	22469755
Pubmed	X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex.	NFKBIB RELA	7.07e-06	2	93	2	12686541
Pubmed	Chronic deficit in nitric oxide elicits oxidative stress and augments T-type calcium-channel contribution to vascular tone of rodent arteries and arterioles.	CACNA1H CACNA1G	7.07e-06	2	93	2	23436820
Pubmed	Different distribution of Cav3.2 and Cav3.1 transcripts encoding T-type Ca(2+) channels in the embryonic heart of mice.	CACNA1H CACNA1G	7.07e-06	2	93	2	21079360
Pubmed	CACNA1H downregulation induces skeletal muscle atrophy involving endoplasmic reticulum stress activation and autophagy flux blockade.	CACNA1C CACNA1H	7.07e-06	2	93	2	32332705
Pubmed	Deficiency of T-type Ca2+ channels Cav3.1 and Cav3.2 has no effect on angiotensin II-induced hypertension but differential effect on plasma aldosterone in mice.	CACNA1H CACNA1G	7.07e-06	2	93	2	31042060
Pubmed	The Ca(v)3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice.	CACNA1H CACNA1G	7.07e-06	2	93	2	22886848
Pubmed	CACNA1I gain-of-function mutations differentially affect channel gating and cause neurodevelopmental disorders.	CACNA1C CACNA1I	7.07e-06	2	93	2	33704440
Pubmed	Deletion of T-type calcium channels Cav3.1 or Cav3.2 attenuates endothelial dysfunction in aging mice.	CACNA1H CACNA1G	7.07e-06	2	93	2	29082441
Pubmed	Role of unphosphorylated, newly synthesized I kappa B beta in persistent activation of NF-kappa B.	NFKBIB RELA	7.07e-06	2	93	2	8816457
Pubmed	[Decreased mRNA expressions of T-type channel alpha1H and alpha1G in the sperm of varicocele patients and their implication].	CACNA1H CACNA1G	7.07e-06	2	93	2	22574369
Pubmed	Blockade of T-type Ca(2+) channels inhibits human ovarian cancer cell proliferation.	CACNA1H CACNA1G	7.07e-06	2	93	2	21438841
Pubmed	β-Adrenergic stimulation increases Cav3.1 activity in cardiac myocytes through protein kinase A.	CACNA1H CACNA1G	7.07e-06	2	93	2	22808078
Pubmed	Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.	PRAMEF7 PRAMEF15 PRAMEF8 PRAMEF11	7.17e-06	46	93	4	17287250
Pubmed	Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain.	HSPD1 UBE2O UBR4 HUWE1	1.00e-05	50	93	4	17550899
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	PRAMEF7 PRAMEF15 PRAMEF8 PRAMEF11	1.00e-05	50	93	4	31806660
Pubmed	Calcium handling precedes cardiac differentiation to initiate the first heartbeat.	CACNA1C CACNA1H CACNA1G	1.22e-05	17	93	3	27725084
Pubmed	ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.	PRAMEF7 PRAMEF15 PRAMEF8 PRAMEF11	1.82e-05	58	93	4	31598710
Pubmed	An abundance of X-linked genes expressed in spermatogonia.	PRAMEF7 PRAMEF15 PRAMEF8 PRAMEF11	1.95e-05	59	93	4	11279525
Pubmed	Tyrosine phosphorylation activates surface chaperones facilitating sperm-zona recognition.	HSPD1 HSP90B2P	2.12e-05	3	93	2	15252132
Pubmed	5,6-EET potently inhibits T-type calcium channels: implication in the regulation of the vascular tone.	CACNA1H CACNA1G	2.12e-05	3	93	2	24327205
Pubmed	KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta x NF-kappaB complexes.	NFKBIB RELA	2.12e-05	3	93	2	12672800
Pubmed	The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor.	NUTM2B NUTM2A	2.12e-05	3	93	2	22456610
Pubmed	Differential effect of T-type voltage-gated Ca2+ channel disruption on renal plasma flow and glomerular filtration rate in vivo.	CACNA1H CACNA1G	2.12e-05	3	93	2	24966091
Pubmed	Efficient replication by herpes simplex virus type 1 involves activation of the IkappaB kinase-IkappaB-p65 pathway.	NFKBIB RELA	2.12e-05	3	93	2	15564469
Pubmed	Association study between polymorphisms in the CACNA1A, CACNA1C, and CACNA1H genes and drug-resistant epilepsy in the Chinese Han population.	CACNA1C CACNA1H	2.12e-05	3	93	2	26216687
Pubmed	NOS1-derived nitric oxide promotes NF-κB transcriptional activity through inhibition of suppressor of cytokine signaling-1.	SOCS1 RELA	2.12e-05	3	93	2	26324446
Pubmed	SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.	RELA SIRT5	2.12e-05	3	93	2	19135889
Pubmed	Caveolin-3 regulates protein kinase A modulation of the Ca(V)3.2 (alpha1H) T-type Ca2+ channels.	CACNA1H CACNA1G	2.12e-05	3	93	2	21084288
Pubmed	Global genetic deletion of CaV3.3 channels facilitates anaesthetic induction and enhances isoflurane-sparing effects of T-type calcium channel blockers.	CACNA1I CACNA1G	2.12e-05	3	93	2	33299036
Pubmed	Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice.	CACNA1C CACNA1G	2.12e-05	3	93	2	22133878
Pubmed	[Expression of HSP60, TLR4 and NF-kappaBp65 in the peripheral blood of patients with atopic dermatitis].	HSPD1 RELA	2.12e-05	3	93	2	19764566
Pubmed	ZnT-1 enhances the activity and surface expression of T-type calcium channels through activation of Ras-ERK signaling.	CACNA1H CACNA1G	2.12e-05	3	93	2	22572848
Pubmed	The effects of labour and of interleukin 1 beta upon the expression of nuclear factor kappa B related proteins in human amnion.	NFKBIB RELA	2.12e-05	3	93	2	12651903
Pubmed	Expression of voltage sensitive calcium channel (VSCC) L-type Cav1.2 (alpha1C) and T-type Cav3.2 (alpha1H) subunits during mouse bone development.	CACNA1C CACNA1H	2.12e-05	3	93	2	16059921
Pubmed	Growth differentiation factor-15 promotes glutamate release in medial prefrontal cortex of mice through upregulation of T-type calcium channels.	CACNA1I CACNA1G	2.12e-05	3	93	2	27353765
Pubmed	LAMB3 Promotes Intestinal Inflammation Through SERPINA3 and Is Directly Transcriptionally Regulated by P65 in Inflammatory Bowel Disease.	SERPINA3 RELA	2.12e-05	3	93	2	37454278
Pubmed	Eps15 Homology Domain-containing Protein 3 Regulates Cardiac T-type Ca2+ Channel Targeting and Function in the Atria.	CACNA1H CACNA1G	2.12e-05	3	93	2	25825486
Pubmed	Negative transcriptional regulation of human colonic smooth muscle Cav1.2 channels by p50 and p65 subunits of nuclear factor-kappaB.	CACNA1C RELA	2.12e-05	3	93	2	16285952
Pubmed	Association of single nucleotide polymorphisms in CACNA 1A/CACNA 1C/CACNA 1H calcium channel genes with diabetic peripheral neuropathy in Chinese population.	CACNA1C CACNA1H	2.12e-05	3	93	2	29581247
Pubmed	The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney.	NUTM2E NUTM2B	2.12e-05	3	93	2	26542179
Pubmed	IκBβ enhances the generation of the low-affinity NFκB/RelA homodimer.	NFKBIB RELA	2.12e-05	3	93	2	25946967
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	PLEKHH1 WHRN DNAH3 TCF20 UBR4 DLG3	3.97e-05	233	93	6	37704626
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	HSPD1 HSP90B2P MTHFD1L UBR4 DIAPH1 CHD4 HUWE1	3.98e-05	344	93	7	30333137
Pubmed	Adult loss of Cacna1a in mice recapitulates childhood absence epilepsy by distinct thalamic bursting mechanisms.	CACNA1H CACNA1G	4.23e-05	4	93	2	31800012
Pubmed	Unmasking early colorectal cancer clues: in silico and in vitro investigation of downregulated IGF2, SOCS1, MLH1, and CACNA1G in SSA polyps.	SOCS1 CACNA1G	4.23e-05	4	93	2	38874740
Pubmed	Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation.	NFKBIB RELA	4.23e-05	4	93	2	8657102
Pubmed	TRIM26 promotes non-small cell lung cancer survival by inducing PBX1 degradation.	UBR4 HUWE1	4.23e-05	4	93	2	37324936
Cytoband	1p36.21	PRAMEF7 PRAMEF25 PRAMEF9 PRAMEF15 PRAMEF8 PRAMEF11	3.63e-09	63	93	6	1p36.21
Cytoband	Ensembl 112 genes in cytogenetic band chr1p36	PRAMEF7 PRAMEF25 PRAMEF9 UBR4 PRAMEF15 PRAMEF8 PRAMEF11	4.82e-04	681	93	7	chr1p36
GeneFamily	PRAME family	PRAMEF7 PRAMEF25 PRAMEF9 PRAMEF15 PRAMEF8 PRAMEF11	1.80e-10	24	63	6	686
GeneFamily	Calcium voltage-gated channel subunits	CACNA1C CACNA1I CACNA1H CACNA1G	1.89e-06	26	63	4	253
GeneFamily	PDZ domain containing	MPP2 WHRN INTU DLG3 PARD3B	1.87e-04	152	63	5	1220
GeneFamily	Kallikreins	KLK15 KLK9	1.39e-03	16	63	2	616
GeneFamily	Calcium voltage-gated channel subunits\|Membrane associated guanylate kinases	MPP2 DLG3	3.68e-03	26	63	2	904
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3_UNMETHYLATED	PRAMEF7 NRK PRAMEF15 PRAMEF8 PRAMEF11	1.64e-06	57	91	5	MM1262
Coexpression	KINNEY_DNMT1_METHYLATION_TARGETS	PRAMEF7 PRAMEF15 PRAMEF8 PRAMEF11	5.82e-06	34	91	4	MM955
Coexpression	MORI_SMALL_PRE_BII_LYMPHOCYTE_UP	PRAMEF7 PRAMEF15 PRAMEF8 PTGER2 PRAMEF11	2.38e-05	98	91	5	MM592
Coexpression	HUANG_GATA2_TARGETS_DN	PRAMEF7 MTHFD1L PRAMEF15 PRAMEF8 PRAMEF11	2.38e-05	98	91	5	MM942
Coexpression	BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS	HSPD1 PRAMEF7 ZNF703 SERPINA3 PRAMEF15 PIPOX SOCS1 DLG3 CACNA1G EXTL3 PRAMEF8 PRAMEF11	4.77e-05	871	91	12	MM1005
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Monophasic_Synovial_Sarcoma-5\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	PRAMEF7 PRAMEF9 PRAMEF15 KLK9 PRAMEF11	1.52e-06	93	93	5	3e05ea0f8f4a7cdb78a596f47d563dc3c94d4d8e
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_3\|368C / Donor, Lineage, Cell class and subclass (all cells)	WHRN TCF20 AP1G1 SENP6 DLG3 CHPF2	2.22e-06	181	93	6	b193f3606554adc55c5906219d114288bb1f978a
Drug	Cinnarizine	CACNA1C CACNA1I CACNA1H CACNA1G	2.83e-08	9	90	4	DB00568
Drug	1,3-dioxoisoindoline-5-carboxamide	CACNA1I CACNA1H CACNA1G	5.97e-08	3	90	3	CID010679219
Drug	Mibefradil	CACNA1C CACNA1I CACNA1H CACNA1G	7.38e-08	11	90	4	DB01388
Drug	pentasulfane	B3GAT1 CACNA1I CACNA1H CACNA1G	4.01e-07	16	90	4	CID000448216
Drug	Flunarizine	CACNA1I CACNA1H CACNA1G	5.94e-07	5	90	3	DB04841
Drug	cyclopropanecarboxylic acid	KLK15 CACNA1I CACNA1H CACNA1G	8.46e-07	19	90	4	CID000015655
Drug	3,4-dihydroquinazoline	CACNA1I CACNA1H CACNA1G	1.18e-06	6	90	3	CID000583065
Drug	LY215840	CACNA1I CACNA1H CACNA1G	2.07e-06	7	90	3	CID000132049
Drug	IAA-94	CACNA1C FLT4 CACNA1I CACNA1H CACNA1G	4.31e-06	61	90	5	CID000003667
Drug	AC1L2AC7	CACNA1C CACNA1I CACNA1H CACNA1G RELA	7.94e-06	69	90	5	CID000068733
Drug	CNS 1145	CACNA1C CACNA1I CACNA1H CACNA1G	8.56e-06	33	90	4	CID000190902
Drug	IHC-64	CACNA1C CACNA1I CACNA1H CACNA1G	8.56e-06	33	90	4	CID000162753
Drug	EBNs	CACNA1I CACNA1H CACNA1G	9.63e-06	11	90	3	CID000150695
Drug	amlodipine	KLK15 CACNA1C KLK9 CACNA1I CACNA1H CACNA1G	1.09e-05	126	90	6	CID000002162
Drug	C75; Down 200; 10uM; PC3; HT_HG-U133A	DENND2A FZR1 FLT4 RPAP1 ABCB9 NFKBIB SIRT5	1.09e-05	191	90	7	6399_DN
Drug	alanine	TCF20 MRGPRE PIPOX SENP6 SOCS1 DLG3 SLC38A3 LAP3	1.15e-05	269	90	8	CID000000602
Drug	themisone	CACNA1I CACNA1H CACNA1G	1.28e-05	12	90	3	CID000016235
Drug	AC1L2VU3	CACNA1I CACNA1H CACNA1G	1.28e-05	12	90	3	CID000129572
Drug	N6-methyladenosine [1867-73-8]; Down 200; 14.2uM; PC3; HT_HG-U133A	WHRN DNAH3 FZR1 NFKBIB SENP6 CACNA1I BRINP1	1.33e-05	197	90	7	6732_DN
Drug	Triamterene [396-01-0]; Up 200; 15.8uM; PC3; HT_HG-U133A	WHRN DENND2A FLT4 ABCB9 EXTL3 SIRT5 PPP4R4	1.37e-05	198	90	7	7307_UP
Drug	Guanabenz acetate [23256-50-0]; Down 200; 13.8uM; MCF7; HT_HG-U133A	MPP2 DNAH3 FZR1 ABCB9 NFKBIB SOCS1 EXTL3	1.37e-05	198	90	7	1544_DN
Drug	Oleandomycin phosphate [7060-74-4]; Down 200; 5uM; PC3; HT_HG-U133A	ABCB9 NFKBIB DIAPH1 DLG3 CACNA1I BRINP1 PTGER2	1.42e-05	199	90	7	4615_DN
Drug	Mibefradil	CACNA1I CACNA1H CACNA1G	1.66e-05	13	90	3	ctd:D020748
Drug	tetralol	CACNA1I CACNA1H CACNA1G	1.66e-05	13	90	3	CID000010747
Drug	nicotinamide ribose	MTHFD1L NRK SOCS1 SLC38A3 SIRT5	1.85e-05	82	90	5	CID000000940
Drug	butamben	CACNA1C CACNA1I CACNA1H	2.63e-05	15	90	3	CID000002482
Drug	Verapamil	CACNA1C CACNA1I CACNA1G	3.22e-05	16	90	3	DB00661
Drug	Zonisamide	CACNA1I CACNA1H CACNA1G	3.90e-05	17	90	3	DB00909
Drug	efonidipine	CACNA1C CACNA1I CACNA1H	3.90e-05	17	90	3	CID000119170
Drug	TLCK	KLK15 SERPINA3 ACP2 NFKBIB KLK9 RELA	3.91e-05	158	90	6	CID000004427
Drug	KW-3049	CACNA1C CACNA1I CACNA1H CACNA1G	4.58e-05	50	90	4	CID000002324
Drug	SureCN2398996	CACNA1I CACNA1H	4.62e-05	3	90	2	CID010220069
Drug	N-desmethylmethsuximide	CACNA1I CACNA1H	4.62e-05	3	90	2	CID000092154
Drug	mercury	HSPD1 CACNA1C ACP2 NFKBIB SENP6 CACNA1I CACNA1H CACNA1G RELA LAP3	5.59e-05	542	90	10	CID000023931
Drug	felodipine	CACNA1C CYP17A1 CACNA1I CACNA1H CACNA1G CYP2S1	5.69e-05	169	90	6	CID000003333
Drug	AC1Q6PMP	SERPINA3 FLT4 NFKBIB SENP6 KLK9 LAP3	5.69e-05	169	90	6	CID000103535
Drug	TMB-8	CACNA1C NFKBIB DLG3 CACNA1I CACNA1H CACNA1G	7.13e-05	176	90	6	CID000005494
Drug	Cinildipine	CACNA1C CACNA1I CACNA1H CACNA1G	7.17e-05	56	90	4	CID000002752
Drug	Hoe 140	KLK15 KLK9 B3GAT1 RELA PTGER2	7.62e-05	110	90	5	CID000071362
Drug	methsuximide	CACNA1I CACNA1H	9.22e-05	4	90	2	CID000006476
Drug	nilvadipine	CACNA1C CACNA1I CACNA1H CACNA1G	9.40e-05	60	90	4	CID000004494
Drug	AC1NBU2S	CACNA1C CACNA1I CACNA1H CACNA1G RELA	1.02e-04	117	90	5	CID004473765
Drug	ionomycin calcium salt; Up 200; 2uM; MCF7; HT_HG-U133A_EA	SERPINA3 FZR1 NFKBIB HUWE1 NPVF PPP4R4	1.06e-04	189	90	6	882_UP
Drug	Pimozide [2062-78-4]; Down 200; 8.6uM; HL60; HG-U133A	FZR1 AP1G1 DEF8 DIAPH1 CHPF2 DHX8	1.12e-04	191	90	6	1562_DN
Drug	lercanidipine	CACNA1C CACNA1I CACNA1H CACNA1G	1.14e-04	63	90	4	CID000065866
Drug	PNU-0251126 [267429-19-6]; Down 200; 10uM; PC3; HT_HG-U133A	DNAH3 FZR1 DIAPH1 DLG3 TEP1 SIRT5	1.18e-04	193	90	6	7388_DN
Drug	Bepridil hydrochloride [74764-40-2]; Down 200; 10uM; MCF7; HT_HG-U133A	FZR1 ABCB9 DLG3 EXTL3 SIRT5 RPL18	1.22e-04	194	90	6	5674_DN
Drug	Phenacetin [62-44-2]; Down 200; 22.4uM; PC3; HT_HG-U133A	FLT4 ZBTB43 DIAPH1 SOCS1 DLG3 EXTL3	1.25e-04	195	90	6	3992_DN
Drug	trichostatin A; Up 200; 0.1uM; HL60; HG-U133A	SERPINA3 DNAH3 NTAN1 SENP6 DLG3 CACNA1I	1.25e-04	195	90	6	364_UP
Drug	Mefexamide hydrochloride [3413-64-7]; Up 200; 12.6uM; PC3; HT_HG-U133A	FZR1 ZBTB43 SENP6 DLG3 PTGER2 SIRT5	1.25e-04	195	90	6	2121_UP
Drug	Flurbiprofen [5104-49-4]; Down 200; 16.4uM; MCF7; HT_HG-U133A	MPP2 FLT4 CYP17A1 SOCS1 PTGER2 RPL18	1.25e-04	195	90	6	5269_DN
Drug	GSK-3 Inhibitor IX; Up 200; 0.5uM; PC3; HT_HG-U133A	FZR1 ABCB9 CYP17A1 NFKBIB CHPF2 PPP4R4	1.25e-04	195	90	6	7048_UP
Drug	Heliotrine [303-33-3]; Down 200; 12.8uM; MCF7; HT_HG-U133A	MPP2 WHRN FZR1 NFKBIB CACNA1H EXTL3	1.29e-04	196	90	6	4739_DN
Drug	Beclomethasone dipropionate [5534-09-8]; Down 200; 7.6uM; MCF7; HT_HG-U133A	FLT4 CYP17A1 NFKBIB DIAPH1 SOCS1 CACNA1H	1.29e-04	196	90	6	4403_DN
Drug	Cefamandole sodium salt [30034-03-8]; Down 200; 8.2uM; MCF7; HT_HG-U133A	MPP2 FZR1 RPAP1 ABCB9 NFKBIB BRINP1	1.29e-04	196	90	6	4718_DN
Drug	Ethamsylate [2624-44-4]; Up 200; 15.2uM; MCF7; HT_HG-U133A	FZR1 NFKBIB CACNA1H TEP1 DHX8 RPL18	1.29e-04	196	90	6	7335_UP
Drug	hydroxamates	CACNA1I CACNA1H CACNA1G	1.29e-04	25	90	3	CID000033630
Drug	Naringin hydrate [11032-30-7]; Down 200; 6.6uM; MCF7; HT_HG-U133A	MPP2 FZR1 ABCB9 CYP17A1 EXTL3 RPL18	1.32e-04	197	90	6	5666_DN
Drug	genistein; Down 200; 10uM; MCF7; HT_HG-U133A	FZR1 ABCB9 CYP17A1 NFKBIB CACNA1G EXTL3	1.32e-04	197	90	6	5595_DN
Drug	Bisacodyl [603-50-9]; Up 200; 11uM; HL60; HT_HG-U133A	WHRN FZR1 ABCB9 DLG3 CACNA1I BRINP1	1.32e-04	197	90	6	2435_UP
Drug	Doxazosin mesylate [77883-43-3]; Down 200; 7.4uM; MCF7; HT_HG-U133A	MPP2 WHRN NFKBIB CACNA1H EXTL3 SIRT5	1.32e-04	197	90	6	3363_DN
Drug	alpha-estradiol; Up 200; 0.01uM; PC3; HT_HG-U133A	FZR1 ABCB9 NFKBIB CHPF2 EXTL3 TEP1	1.32e-04	197	90	6	1210_UP
Drug	Sulfamethizole [144-82-1]; Down 200; 14.8uM; MCF7; HT_HG-U133A	MPP2 RPAP1 ABCB9 NFKBIB CACNA1I RPL18	1.32e-04	197	90	6	6099_DN
Drug	Tinidazole [19387-91-8]; Down 200; 16.2uM; MCF7; HT_HG-U133A	WHRN RPAP1 CACNA1I CACNA1H SIRT5 PPP4R4	1.36e-04	198	90	6	4370_DN
Drug	Ungerine nitrate; Down 200; 10.2uM; PC3; HT_HG-U133A	MPP2 WHRN DNAH3 ZBTB43 DIAPH1 SENP6	1.36e-04	198	90	6	5816_DN
Drug	Amiodarone hydrochloride [19774-82-4]; Down 200; 5.8uM; MCF7; HT_HG-U133A	MPP2 ABCB9 CYP17A1 DIAPH1 PIPOX PTGER2	1.36e-04	198	90	6	5253_DN
Drug	AC1L1TJF	CACNA1C CACNA1I CACNA1H CACNA1G	1.36e-04	66	90	4	CID000003377
Drug	Methyldopate hydrochloride [2508-79-4]; Down 200; 14.6uM; PC3; HT_HG-U133A	FLT4 ABCB9 SENP6 CACNA1I BRINP1 TEP1	1.40e-04	199	90	6	6640_DN
Drug	Loxapine succinate [27833-64-3]; Down 200; 9uM; HL60; HG-U133A	DNAH3 NFATC2IP ZBTB43 TMEM115 RELA RPL18	1.40e-04	199	90	6	2016_DN
Drug	wortmannin from Penicillium funiculosum; Down 200; 0.01uM; MCF7; HT_HG-U133A	FZR1 ABCB9 CYP17A1 NFKBIB EXTL3 RPL18	1.44e-04	200	90	6	5603_DN
Drug	gallopamil	CACNA1C CACNA1I CACNA1H CACNA1G	1.45e-04	67	90	4	CID000001234
Drug	N-carbamoylsarcosine	RTL1 PIPOX	1.53e-04	5	90	2	CID000439375
Drug	phensuximide	CACNA1I CACNA1H	1.53e-04	5	90	2	CID000006839
Drug	AC1O7G5C	CACNA1I CACNA1H	1.53e-04	5	90	2	CID006603942
Drug	enzacamene	CACNA1C CYP17A1 CACNA1I CACNA1H CACNA1G	1.61e-04	129	90	5	ctd:C038939
Drug	potassium	HSPD1 KLK15 CACNA1C FLT4 CYP17A1 ACP2 KLK9 DLG3 CACNA1I CACNA1H CACNA1G RELA SLC38A3	1.62e-04	1008	90	13	CID000000813
Drug	aldosterone	KLK15 CACNA1C CYP17A1 KLK9 CACNA1I CACNA1H CACNA1G RELA	1.78e-04	397	90	8	CID000005839
Drug	Barium	CACNA1C CACNA1I CACNA1H CACNA1G	1.91e-04	72	90	4	ctd:D001464
Drug	CAS 298-57-7	CACNA1C CACNA1I CACNA1H CACNA1G	2.02e-04	73	90	4	CID000002761
Drug	rufinamide	CACNA1I CACNA1H CACNA1G	2.03e-04	29	90	3	CID000129228
Drug	ethosuximide	CACNA1C CACNA1I CACNA1H CACNA1G	2.13e-04	74	90	4	CID000003291
Drug	Androgen Antagonists	CACNA1C CYP17A1 CACNA1I CACNA1G	2.24e-04	75	90	4	ctd:D000726
Drug	anacardic acid	CACNA1I CACNA1H CACNA1G	2.24e-04	30	90	3	CID000167551
Drug	octylmethoxycinnamate	CACNA1C CYP17A1 CACNA1I CACNA1H CACNA1G	2.29e-04	139	90	5	ctd:C118580
Drug	cerebrocrast	CACNA1I CACNA1H	2.29e-04	6	90	2	CID000159556
Drug	AC1MQ5W8	CACNA1I CACNA1H	2.29e-04	6	90	2	CID003396482
Drug	jasplakinolide	CACNA1C DIAPH1 CACNA1H	2.48e-04	31	90	3	ctd:C057531
Drug	nisoldipine	CACNA1C CACNA1I CACNA1H CACNA1G	2.60e-04	78	90	4	CID000004499
Drug	isovalerate	CACNA1C CACNA1I CACNA1H CACNA1G NPVF	2.61e-04	143	90	5	CID000010430
Drug	N-cyclopentyl-N-cyclobutylformamide	CACNA1C CACNA1I CACNA1H CACNA1G	2.74e-04	79	90	4	CID005287890
Drug	lactofen	SOCS1 CACNA1I CACNA1H CACNA1G	3.01e-04	81	90	4	CID000062276
Drug	AC1Q6PCP	KLK15 KLK9 CACNA1I CACNA1H CACNA1G RELA	3.06e-04	230	90	6	CID000005267
Drug	Isradipine	CACNA1C CACNA1H	3.20e-04	7	90	2	DB00270
Drug	CID5199640	HSPD1 EXTL3	3.20e-04	7	90	2	CID005199640
Drug	cyclotriphosphazene	FLT4 KLK9	3.20e-04	7	90	2	CID000120195
Drug	losigamone	CACNA1I CACNA1H	3.20e-04	7	90	2	CID000060572
Disease	Endometrial Stromal Sarcoma	NUTM2B NUTM2A	8.15e-05	5	85	2	C0206630
Disease	Clear cell sarcoma of kidney	NUTM2E NUTM2B	1.22e-04	6	85	2	C0334488
Disease	lymphoma (is_implicated_in)	RELA CHD4	1.22e-04	6	85	2	DOID:0060058 (is_implicated_in)
Disease	alpha-1-antitrypsin measurement	SERPINA3 PPP4R4	2.91e-04	9	85	2	EFO_0008327
Disease	response to bronchodilator, FEV/FEC ratio	MPP2 CACNA1C PAMR1 RP1L1 PARD3B GRID1 BRINP1 DDX24 PPP4R4	3.62e-04	766	85	9	EFO_0004713, GO_0097366
Disease	sphingomyelin 18:1 measurement	CACNA1C PARD3B	6.27e-04	13	85	2	EFO_0010394
Disease	Mental Retardation, X-Linked Nonsyndromic	DLG3 HUWE1	6.27e-04	13	85	2	C3501611
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	HSPD1 FLT4 RELA YIPF3	8.98e-04	148	85	4	C0279702
Disease	body weight	MPP2 CACNA1C NTAN1 ZBTB43 SENP6 LSAMP PARD3B GRID1 MICA BRINP1 HUWE1	9.78e-04	1261	85	11	EFO_0004338
Disease	banks of the superior temporal sulcus volume measurement	AP1G1 GRID1	1.08e-03	17	85	2	EFO_0010286
Disease	Tourette syndrome, schizophrenia	TCF20 CACNA1I	1.22e-03	18	85	2	EFO_0004895, MONDO_0005090
Disease	gut microbiome measurement, bone density	MPP2 SENP6 GRID1	1.50e-03	78	85	3	EFO_0003923, EFO_0007874
Disease	uveitis (biomarker_via_orthology)	SERPINA3 RELA	2.36e-03	25	85	2	DOID:13141 (biomarker_via_orthology)
Disease	response to TNF antagonist, joint damage measurement	MPP2 BRINP1	2.36e-03	25	85	2	EFO_0004653, EFO_0005413

Protein segments in the cluster

Peptide	Gene	Start	Entry
PRIPRGTMQRNLALR	B3GAT1	161	Q9P2W7
MPRFASPLLRNVIIR	C21orf140	1	B9A014
PLMPEFQRSIRLLGR	BRINP1	96	O60477
TIVRFNRPFLMIIVP	SERPINA3	391	P01011
RIVQMLLPVTSRTRI	ASB2	351	Q96Q27
RELPRPMLLVLRNIN	ADCK5	471	Q3MIX3
TVFRQMRPVSRVLAP	HSPD1	6	P10809
VMGTVPRLRPRLNAI	DIAPH1	926	O60610
MGTRLPLVLRQLRRP	MTHFD1L	1	Q6UB35
RLPQTRRRIIMVPRK	EFCAB12	51	Q6NXP0
LRRTVPPMVNVTRSE	MICA	201	Q29983
MPAPIRLRELIRTIR	AP1G1	1	O43747
MFLLPLPAAGRVVVR	LAP3	1	P28838
VLRRIRGPLLAQEMP	PATL1	131	Q86TB9
RGMIQLVILRRPERP	PARD3B	581	Q8TEW8
INPRHPLIRDMLRRI	HSP90B2P	326	Q58FF3
QRLLALVPMGIPRTL	CYP2S1	361	Q96SQ9
AMLRPNPILARLLRA	NFKBIB	281	Q15653
DIMLLRLVQPARLNP	KLK15	106	Q9H2R5
RTMLLPLLRRFPEQV	PGS1	176	Q32NB8
AILRPPVLRLMRSVL	PTGER2	316	P43116
ESRMPHLRLVLPITR	FAM47B	391	Q8NA70
PRMRGRQPLTVFVEL	PRAMEF15	141	P0DUQ1
VARMPPFRRKTLVLI	MPP2	366	Q14168
VVRLVFPTSQEPLMR	PLA2G4B	226	P0C869
SLMLLLRVERGPQRP	MRGPRE	196	Q86SM8
RPVMLTLLRVPRLNK	HUWE1	1676	Q7Z6Z7
PLPRLRNMIENVIQT	INTU	396	Q9ULD6
NLVVMPPTRARSLRF	ACP2	21	P11117
RMILQRDIRTPPLQS	FZR1	291	Q9UM11
ARRVRPVSLMVPSQA	CACNA1C	2091	Q13936
RPLRAINRVPSMRIL	CACNA1G	186	O43497
LPINPTIIRIMRVLR	CACNA1G	1701	O43497
IPPLTMKRIRERFIN	DNAH3	2851	Q8TD57
KRRGISPALVQPLMR	DENND2A	686	Q9ULE3
VRIPVSRPILMLRAP	FCRL1	201	Q96LA6
LAMIRTRIQIPAAPI	EXTL3	531	O43909
RVLRPLKAINRVPSM	CACNA1I	181	Q9P0X4
LVRFMPALRRQLVVL	CACNA1I	741	Q9P0X4
ALPINPTIIRIMRVL	CACNA1I	1576	Q9P0X4
PTIIRIMRVLRIARV	CACNA1I	1581	Q9P0X4
TIREVLRLRPVAPML	CYP17A1	356	P05093
RLVVRRRQPPPETIM	DLG3	211	Q92796
PRMPVLLLLRRQEAR	C20orf144	91	Q9BQM9
QRMLNRRPEIVVATP	DDX24	431	Q9GZR7
LMVSRPVLRLREINP	DEF8	341	Q6ZN54
LASRPPVRLNDVMLR	GRID1	141	Q9ULK0
DIMLIRLPRQARLSP	KLK9	111	Q9UKQ9
RIPLPRRTKMAAVTL	COX15	346	Q7KZN9
PLRAINRVPSMRILV	CACNA1H	206	O95180
ALPINPTIIRIMRVL	CACNA1H	1706	O95180
PTIIRIMRVLRIARV	CACNA1H	1711	O95180
ARIPPVAVRLQMSER	CHD4	1876	Q14839
MSIRAPPRLLELARQ	PRAMEF8	1	Q5VWM4
LISNLLRLIQTMRPP	DHX8	81	Q14562
MRQPAVRLVRLGRVP	LIPT2	1	A6NK58
MRQTLPLLLLTVLRP	LRRN4	1	Q8WUT4
RRRVLPMQVQSRETP	PAMR1	356	Q6UXH9
IPVLRSLARRKPTMT	NUTM2A	361	Q8IVF1
IPVLRSLARRKPTMT	NUTM2B	361	A6NNL0
IPVLRSLARRKPTMT	NUTM2E	361	B1AL46
LQMQIKAPPRLRRAA	NRK	461	Q7Z2Y5
RVLMPLQAQVRAPRL	NRK	476	Q7Z2Y5
VRQCLSLRPAPAMRV	RTL1	1101	A6NKG5
VRKPSMRPRNLTEVL	RGSL1	636	A5PLK6
VPIVLFPVRRAIQQM	SLC38A3	381	Q99624
LMRQNPTETLRRVLP	PPP4R4	81	Q6NUP7
QRLLRVPRPMPLIQS	TOGARAM2	166	Q6ZUX3
MVRRVQPDRKQLPLV	LSAMP	1	Q13449
PRMRGRQPLTVFVEL	PRAMEF25	141	A6NGN4
GQKLEPIPHRRLRMV	SIMC1	461	Q8NDZ2
PIPHRRLRMVTNTIE	SIMC1	466	Q8NDZ2
RVRMPVGSPLLRDNV	MRPS18A	171	Q9NVS2
LPMLRLVIPRSDQLL	WHRN	91	Q9P202
MPLLVEGRRVRLPQS	NTAN1	1	Q96AB6
VRLPLRMSEPLQSVV	NFATC2IP	276	Q8NCF5
MLGAPLRQRRVRPLQ	SOCS1	161	O15524
VAMARALVRNPPVLI	ABCB9	651	Q9NP78
VSLLRPLSRVEILPM	CHPF2	466	Q9P2E5
NSRRIVLPDVMNPRV	ZBTB43	66	O43298
MSIRAPPRLLELARQ	PRAMEF7	1	Q5VXH5
PLRQANRLPIRVLKM	ZNF703	41	Q9H7S9
VVLKRLFMSRTNRPP	RPL18	46	Q07020
PFPSNITLMRRILTR	TEP1	586	Q99973
MEVSLVRRVPNLPQR	NPVF	116	Q9HCQ7
PRRILLIKNMDPRLQ	RP1L1	151	Q8IWN7
PRMRGRQPLTVFVEL	PRAMEF9	141	P0DUQ2
CVVLRVPQVRVSVMP	TMEM115	156	Q12893
APELATPAIRRIMLN	FLT4	1136	P35916
IRVVQSMTQLVRRPP	UBE2O	1106	Q9C0C9
PRMRGRQPLTVFVEL	PRAMEF11	141	O60813
PPRMRTKREEIRNII	SENP6	1061	Q9GZR1
PVLMRALQVVPRELS	RPAP1	696	Q9BWH6
LIMRRRVRSFISPIP	TCF20	1251	Q9UGU0
RPSRMEVVSILLRNP	PLEKHH1	976	Q9ULM0
PAQVRSRLLESMIPI	YIPF3	126	Q9GZM5
RPLGIEMPLQTLRIN	PIPOX	211	Q9P0Z9
MRPLQIVPSRLISQL	SIRT5	1	Q9NXA8
QRLVITARSIAIMRP	UBR4	2571	Q5T4S7
SLQAPVRVSMQLRRP	RELA	261	Q04206
MLRIPRPLIMIRAFR	NALCN	141	Q8IZF0