Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	FOXD2 MYCN ZNF444 SCRT1 SALL3 CEBPD ZNF628 NTN3 ESRRA BHLHA9 INSM1 GATA1 ETV2 IRX3 NR6A1 HMX1 FOXI3 ZNF865 DMBX1 HOXB3 KLF16 BHLHE23 MIXL1 EGR4 TPRX1 HES4 NR5A1 TET3 NPAS4 FOXD1 FOXE3	5.72e-10	1459	122	31	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	FOXD2 MYCN ZNF444 SCRT1 SALL3 CEBPD ZNF628 NTN3 ESRRA BHLHA9 INSM1 GATA1 ETV2 IRX3 NR6A1 HMX1 FOXI3 DMBX1 HOXB3 KLF16 BHLHE23 LBX1 MIXL1 EGR4 TPRX1 HES4 NR5A1 NPAS4 FOXD1 FOXE3	1.17e-09	1412	122	30	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	FOXD2 MYCN ZNF444 SCRT1 SALL3 CEBPD ZNF628 NTN3 ESRRA INSM1 GATA1 ETV2 IRX3 NR6A1 FOXI3 ZNF865 HOXB3 KLF16 BHLHE23 MIXL1 EGR4 TPRX1 HES4 NR5A1 TET3 NPAS4 FOXD1 FOXE3	1.32e-09	1244	122	28	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	FOXD2 MYCN ZNF444 SCRT1 SALL3 CEBPD ZNF628 NTN3 ESRRA INSM1 GATA1 ETV2 IRX3 NR6A1 FOXI3 ZNF865 HOXB3 KLF16 BHLHE23 MIXL1 EGR4 TPRX1 HES4 NR5A1 TET3 NPAS4 FOXD1 FOXE3	2.14e-09	1271	122	28	GO:0000987
GeneOntologyMolecularFunction	low voltage-gated calcium channel activity	CACNA1I CACNA1H CACNA1G	2.23e-07	3	122	3	GO:0008332
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	HCN4 HCN2 CACNA1I CACNA1H CACNA1G	4.65e-07	26	122	5	GO:0005248
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	FOXD2 MYCN CEBPD ZNF628 ESRRA GATA1 ETV2 IRX3 NR6A1 HOXB3 MIXL1 EGR4 NPAS4 FOXD1	8.41e-06	560	122	14	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	FOXD2 MYCN CEBPD ZNF628 ESRRA GATA1 ETV2 IRX3 NR6A1 HOXB3 MIXL1 EGR4 NPAS4 FOXD1	9.49e-06	566	122	14	GO:0001216
GeneOntologyMolecularFunction	sodium channel activity	HCN4 HCN2 CACNA1I CACNA1H CACNA1G	1.62e-05	52	122	5	GO:0005272
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	HCN4 GRIN2D HCN2 KCNQ4 CACNA1I CACNA1H CACNA1G	4.16e-05	152	122	7	GO:0022843
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1I CACNA1H CACNA1G	7.71e-05	14	122	3	GO:0008331
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	HCN4 GRIN2D HCN2 KCNQ4 CACNA1I CACNA1H CACNA1G	1.29e-04	182	122	7	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	HCN4 GRIN2D HCN2 KCNQ4 CACNA1I CACNA1H CACNA1G	1.38e-04	184	122	7	GO:0022832
GeneOntologyMolecularFunction	extracellular matrix structural constituent conferring tensile strength	COL7A1 COL15A1 COL17A1 COL5A3	1.77e-04	46	122	4	GO:0030020
GeneOntologyMolecularFunction	protein domain specific binding	ADAM19 ATN1 ADAM15 ESRRA GATA1 DAZAP2 TACC2 HCN2 DENND1A ADRB1 AP2A2 SNAP91 STRN4 DNM1 VASP	2.90e-04	875	122	15	GO:0019904
GeneOntologyMolecularFunction	protein serine/threonine kinase binding	DAZAP2 AP2A2 DNM1	4.10e-04	24	122	3	GO:0120283
GeneOntologyMolecularFunction	phosphatidylinositol 3-kinase activator activity	PRKD1 AGAP2	1.30e-03	9	122	2	GO:0141038
GeneOntologyMolecularFunction	molecular adaptor activity	BCL9L ATN1 SH2B3 INSM1 NIBAN2 ZFPM1 PARP14 HCN2 STRIP1 AXIN2 AP2A2 SNAP91 STRN4 MAMSTR SYN1 SMARCD2 IRF2BPL SCRIB	1.48e-03	1356	122	18	GO:0060090
GeneOntologyMolecularFunction	intracellularly cAMP-activated cation channel activity	HCN4 HCN2	1.61e-03	10	122	2	GO:0005222
GeneOntologyMolecularFunction	SH3 domain binding	ADAM19 ADAM15 DENND1A DNM1 VASP	1.86e-03	143	122	5	GO:0017124
GeneOntologyMolecularFunction	estrogen response element binding	ESRRA NR6A1	1.96e-03	11	122	2	GO:0034056
GeneOntologyMolecularFunction	kinase binding	MYCN ATN1 SH2B3 DAZAP2 TESK1 STRIP1 AXIN2 AP2A2 SNAP91 SYN1 PRKD1 SCRIB DNM1 AGAP2	2.39e-03	969	122	14	GO:0019900
GeneOntologyMolecularFunction	protein kinase binding	ATN1 SH2B3 DAZAP2 TESK1 STRIP1 AXIN2 AP2A2 SNAP91 SYN1 PRKD1 SCRIB DNM1 AGAP2	2.64e-03	873	122	13	GO:0019901
GeneOntologyMolecularFunction	intracellularly cyclic nucleotide-activated monoatomic cation channel activity	HCN4 HCN2	2.76e-03	13	122	2	GO:0005221
GeneOntologyMolecularFunction	cyclic nucleotide-activated monoatomic ion channel activity	HCN4 HCN2	2.76e-03	13	122	2	GO:0043855
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1I CACNA1H CACNA1G	2.79e-03	46	122	3	GO:0005245
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	SCRT1 ESRRA INSM1 IRX3 HMX1 DMBX1 KLF16	3.54e-03	320	122	7	GO:0001227
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	HJV FOXD2 MYCN BCL9L CEBPD ESRRA GATA1 ETV2 IRX3 ZFPM1 NR6A1 HOXB3 BHLHE23 MIXL1 EGR4 MAMSTR IRF2BPL PRKD1 NR5A1 TAF4 SSBP4 TET3 NPAS4 FOXD1 AGAP2	4.11e-07	1390	121	25	GO:0045944
GeneOntologyBiologicalProcess	membrane depolarization during action potential	HCN4 HCN2 CACNA1I CACNA1H CACNA1G	2.08e-06	36	121	5	GO:0086010
GeneOntologyBiologicalProcess	synaptic vesicle endocytosis	GAK DENND1A AP2A2 SNAP91 SCRIB DNM1	2.17e-05	96	121	6	GO:0048488
GeneOntologyBiologicalProcess	presynaptic endocytosis	GAK DENND1A AP2A2 SNAP91 SCRIB DNM1	3.06e-05	102	121	6	GO:0140238
GeneOntologyBiologicalProcess	synaptic vesicle recycling	GAK DENND1A AP2A2 SNAP91 SCRIB DNM1	4.93e-05	111	121	6	GO:0036465
GeneOntologyBiologicalProcess	membrane depolarization	NEDD4L HCN4 HCN2 CACNA1I CACNA1H CACNA1G	7.98e-05	121	121	6	GO:0051899
GeneOntologyBiologicalProcess	embryo development	MYCN SH2B3 HCN4 FRAT1 DYNC2H1 GATA1 ETV2 IRX3 NIBAN2 ZFPM1 FOXI3 AXIN2 HOXB3 NDEL1 LATS2 LBX1 MIXL1 KCNQ4 SCRIB VASP CNOT3	8.87e-05	1437	121	21	GO:0009790
GeneOntologyBiologicalProcess	positive regulation of mesoderm development	ETV2 MIXL1	1.02e-04	3	121	2	GO:2000382
GeneOntologyBiologicalProcess	calcium ion import across plasma membrane	ADRB1 CACNA1I CACNA1H CACNA1G	1.80e-04	48	121	4	GO:0098703
GeneOntologyBiologicalProcess	calcium ion import into cytosol	ADRB1 CACNA1I CACNA1H CACNA1G	1.80e-04	48	121	4	GO:1902656
GeneOntologyBiologicalProcess	inorganic ion import across plasma membrane	HCN4 HCN2 ADRB1 CACNA1I CACNA1H CACNA1G	1.92e-04	142	121	6	GO:0099587
GeneOntologyBiologicalProcess	inorganic cation import across plasma membrane	HCN4 HCN2 ADRB1 CACNA1I CACNA1H CACNA1G	1.92e-04	142	121	6	GO:0098659
GeneOntologyBiologicalProcess	regulation of definitive erythrocyte differentiation	GATA1 ZFPM1	2.03e-04	4	121	2	GO:0010724
GeneOntologyBiologicalProcess	positive regulation of calcium ion-dependent exocytosis	CACNA1I CACNA1H CACNA1G	2.09e-04	20	121	3	GO:0045956
GeneOntologyBiologicalProcess	cardiac muscle cell contraction	NEDD4L HCN4 ADRB1 CACNA1H CACNA1G	2.20e-04	93	121	5	GO:0086003
GeneOntologyBiologicalProcess	clathrin-dependent endocytosis	GAK AP2A2 SNAP91 DNM1	2.64e-04	53	121	4	GO:0072583
GeneOntologyBiologicalProcess	clathrin coat assembly	GAK SNAP91 DNM1	3.20e-04	23	121	3	GO:0048268
GeneOntologyBiologicalProcess	membrane depolarization during cardiac muscle cell action potential	HCN4 HCN2 CACNA1G	3.20e-04	23	121	3	GO:0086012
GeneOntologyBiologicalProcess	membrane depolarization during SA node cell action potential	HCN4 CACNA1G	3.37e-04	5	121	2	GO:0086046
GeneOntologyCellularComponent	chromatin	FOXD2 MYCN CEBPD ESRRA BHLHA9 GATA1 IRX3 ZFPM1 NR6A1 HMX1 DMBX1 HOXB3 KLF16 BHLHE23 LBX1 MIXL1 EGR4 TPRX1 HES4 SMARCD2 NR5A1 TAF4 NPAS4 FOXD1 FOXE3	1.41e-06	1480	123	25	GO:0000785
GeneOntologyCellularComponent	transcription regulator complex	BCL9L CEBPD INSM1 GATA1 DAZAP2 ZFPM1 NR6A1 DMBX1 LBX1 NR5A1 TAF4 NPAS4 FOXE3	5.04e-05	596	123	13	GO:0005667
GeneOntologyCellularComponent	voltage-gated sodium channel complex	CACNA1I CACNA1H CACNA1G	1.27e-04	17	123	3	GO:0001518
GeneOntologyCellularComponent	collagen trimer	COL7A1 COL15A1 COL17A1 C1QL4 COL5A3	1.72e-04	88	123	5	GO:0005581
GeneOntologyCellularComponent	HCN channel complex	HCN4 HCN2	2.04e-04	4	123	2	GO:0098855
GeneOntologyCellularComponent	sodium channel complex	CACNA1I CACNA1H CACNA1G	6.50e-04	29	123	3	GO:0034706
MousePheno	pale yolk sac	MYCN BCL9L GATA1 ETV2 ZFPM1 NR6A1 SCRIB	2.11e-05	110	107	7	MP:0001722
Domain	VDCC_T_a1	CACNA1I CACNA1H CACNA1G	2.52e-07	3	119	3	IPR005445
Domain	VDCCAlpha1	CACNA1I CACNA1H CACNA1G	2.93e-05	10	119	3	IPR002077
Domain	Ion_trans_dom	HCN4 HCN2 KCNQ4 CACNA1I CACNA1H CACNA1G	8.98e-05	114	119	6	IPR005821
Domain	Ion_trans	HCN4 HCN2 KCNQ4 CACNA1I CACNA1H CACNA1G	8.98e-05	114	119	6	PF00520
Domain	TF_fork_head_CS_2	FOXD2 FOXI3 FOXD1 FOXE3	2.08e-04	46	119	4	IPR030456
Domain	Collagen	COL7A1 COL15A1 COL17A1 C1QL4 COL5A3	2.11e-04	85	119	5	IPR008160
Domain	Collagen	COL7A1 COL15A1 COL17A1 C1QL4 COL5A3	2.11e-04	85	119	5	PF01391
Domain	TF_fork_head_CS_1	FOXD2 FOXI3 FOXD1 FOXE3	2.26e-04	47	119	4	IPR018122
Domain	Ion_trans_N	HCN4 HCN2	2.40e-04	4	119	2	IPR013621
Domain	Ion_trans_N	HCN4 HCN2	2.40e-04	4	119	2	PF08412
Domain	FH	FOXD2 FOXI3 FOXD1 FOXE3	2.66e-04	49	119	4	SM00339
Domain	FORK_HEAD_1	FOXD2 FOXI3 FOXD1 FOXE3	2.66e-04	49	119	4	PS00657
Domain	FORK_HEAD_2	FOXD2 FOXI3 FOXD1 FOXE3	2.66e-04	49	119	4	PS00658
Domain	Fork_head_dom	FOXD2 FOXI3 FOXD1 FOXE3	2.66e-04	49	119	4	IPR001766
Domain	FORK_HEAD_3	FOXD2 FOXI3 FOXD1 FOXE3	2.66e-04	49	119	4	PS50039
Domain	Forkhead	FOXD2 FOXI3 FOXD1 FOXE3	2.66e-04	49	119	4	PF00250
Domain	-	ESRRA GATA1 NR6A1 NR5A1	4.77e-04	57	119	4	3.30.50.10
Domain	Znf_NHR/GATA	ESRRA GATA1 NR6A1 NR5A1	5.10e-04	58	119	4	IPR013088
Domain	ADAM_Cys-rich	ADAM19 ADAM15 ADAMTS13	6.60e-04	27	119	3	IPR006586
Domain	ACR	ADAM19 ADAM15 ADAMTS13	6.60e-04	27	119	3	SM00608
Domain	-	MYCN BHLHA9 BHLHE23 HES4 NPAS4	6.65e-04	109	119	5	4.10.280.10
Domain	HOMEOBOX_1	IRX3 HMX1 DMBX1 HOXB3 LBX1 MIXL1 TPRX1	7.95e-04	236	119	7	PS00027
Domain	HOMEOBOX_2	IRX3 HMX1 DMBX1 HOXB3 LBX1 MIXL1 TPRX1	8.56e-04	239	119	7	PS50071
Domain	Homeobox_dom	IRX3 HMX1 DMBX1 HOXB3 LBX1 MIXL1 TPRX1	8.56e-04	239	119	7	IPR001356
Domain	BHLH	MYCN BHLHA9 BHLHE23 HES4 NPAS4	9.16e-04	117	119	5	PS50888
Domain	bHLH_dom	MYCN BHLHA9 BHLHE23 HES4 NPAS4	9.52e-04	118	119	5	IPR011598
Domain	Homeobox_CS	IRX3 HMX1 DMBX1 HOXB3 LBX1 MIXL1	1.23e-03	186	119	6	IPR017970
Pathway	REACTOME_DEVELOPMENTAL_BIOLOGY	HJV CEBPD NTN3 INSM1 RANBP9 COL5A3 EVPL NR6A1 HOXB3 AP2A2 MIXL1 TPRX1 SMARCD2 CACNA1I CACNA1H CACNA1G NR5A1 DNM1 TET3 VASP CNOT3 AGAP2	4.99e-05	1432	88	22	M509
Pathway	REACTOME_COLLAGEN_CHAIN_TRIMERIZATION	COL7A1 COL15A1 COL17A1 COL5A3	1.20e-04	41	88	4	MM15538
Pathway	REACTOME_NCAM1_INTERACTIONS	COL5A3 CACNA1I CACNA1H CACNA1G	1.32e-04	42	88	4	M7169
Pathway	REACTOME_COLLAGEN_CHAIN_TRIMERIZATION	COL7A1 COL15A1 COL17A1 COL5A3	1.59e-04	44	88	4	M27812
Pubmed	A census of human transcription factors: function, expression and evolution.	FOXD2 MYCN ZNF444 ESRRA BHLHA9 INSM1 GATA1 ETV2 IRX3 ZFPM1 NR6A1 HMX1 FOXI3 DMBX1 HOXB3 KLF16 BHLHE23 LBX1 MIXL1 TPRX1 HES4 NR5A1 FOXE3	1.50e-13	908	124	23	19274049
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	FOXD2 MYCN ZNF444 SCRT1 CEBPD ESRRA GATA1 ETV2 IRX3 NR6A1 HMX1 DMBX1 KLF16 BHLHE23 MIXL1 EGR4 NR5A1	1.16e-11	544	124	17	28473536
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	NEDD4L HCN4 PRR36 RANBP9 GRIN2D HCN2 STRIP1 AP2A2 SNAP91 TMEM259 SEC16A STRN4 SYN1 ELAVL3 PRKD1 SCRIB TAF4 PRRT1 DNM1 AGAP2	2.30e-10	963	124	20	28671696
Pubmed	Ethanol inhibition of a T-type Ca²+ channel through activity of protein kinase C.	CACNA1I CACNA1H CACNA1G	4.42e-08	3	124	3	23488970
Pubmed	Identification of the t-type calcium channel (Ca(v)3.1d) in developing mouse heart.	CACNA1I CACNA1H CACNA1G	4.42e-08	3	124	3	11230107
Pubmed	Homeostatic plasticity and burst activity are mediated by hyperpolarization-activated cation currents and T-type calcium channels in neuronal cultures.	CACNA1I CACNA1H CACNA1G	4.42e-08	3	124	3	33547341
Pubmed	Calmodulin regulates Cav3 T-type channels at their gating brake.	CACNA1I CACNA1H CACNA1G	4.42e-08	3	124	3	28972185
Pubmed	Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type calcium current transient expression during fetal development in mice.	CACNA1I CACNA1H CACNA1G	4.42e-08	3	124	3	11897840
Pubmed	T-type channels: release a brake, engage a gear.	CACNA1I CACNA1H CACNA1G	4.42e-08	3	124	3	26488564
Pubmed	Differential interactions of Na+ channel toxins with T-type Ca2+ channels.	CACNA1I CACNA1H CACNA1G	4.42e-08	3	124	3	18591418
Pubmed	Prognostic relevance of a T-type calcium channels gene signature in solid tumours: A correlation ready for clinical validation.	CACNA1I CACNA1H CACNA1G	4.42e-08	3	124	3	28846697
Pubmed	Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability.	CACNA1I CACNA1H CACNA1G	4.42e-08	3	124	3	11927664
Pubmed	Pharmacogenetics of antiepileptic drug efficacy in childhood absence epilepsy.	CACNA1I CACNA1H CACNA1G	1.76e-07	4	124	3	28165634
Pubmed	LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool.	AP2A2 SNAP91 SYN1 DNM1	2.04e-07	15	124	4	21307259
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ZNF628 SH2B3 FBRS ZFPM1 GRIN2D ZNF865 TESK1 ZDHHC8 DENND1A TNRC18 LATS2 SLC45A3 TMEM259 SEC16A STRN4 CACNA1H SSBP4	4.29e-07	1105	124	17	35748872
Pubmed	Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly.	AP2A2 SNAP91 DNM1	4.40e-07	5	124	3	10430869
Pubmed	Molecular and functional characterization of clathrin- and AP-2-binding determinants within a disordered domain of auxilin.	GAK AP2A2 SNAP91	8.78e-07	6	124	3	12732633
Pubmed	Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.	CACNA1I CACNA1H CACNA1G	2.45e-06	8	124	3	28330839
Pubmed	Neuroepithelial progenitors generate and propagate non-neuronal action potentials across the spinal cord.	CACNA1I CACNA1H CACNA1G	2.45e-06	8	124	3	34478646
Pubmed	Intracellular calcium plays an essential role in cardiac development.	CACNA1I CACNA1H CACNA1G	2.45e-06	8	124	3	12761855
Pubmed	Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.	COL7A1 ADAM19 COL17A1 COL5A3 FGB	2.92e-06	62	124	5	28344315
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1I CACNA1H CACNA1G	3.66e-06	9	124	3	16382099
Pubmed	Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage.	CACNA1I CACNA1H CACNA1G	5.21e-06	10	124	3	24778262
Pubmed	Ovarian development in mice requires the GATA4-FOG2 transcription complex.	IRX3 AXIN2 SYN1 NR5A1	8.30e-06	36	124	4	18927154
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	FOXD2 ESRRA GATA1 TACC2 IRX3 HMX1 DMBX1 IGHMBP2 SMARCD2 EIF3F TRIM47 NPAS4	9.34e-06	709	124	12	22988430
Pubmed	Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.	COL7A1 COL15A1 COL17A1 NEDD4L COL5A3 DMBX1 PRKD1	1.10e-05	210	124	7	16537572
Pubmed	Compartmental distribution of hyperpolarization-activated cyclic-nucleotide-gated channel 2 and hyperpolarization-activated cyclic-nucleotide-gated channel 4 in thalamic reticular and thalamocortical relay neurons.	HCN4 HCN2	1.26e-05	2	124	2	16806719
Pubmed	Protein kinase D1-mediated phosphorylations regulate vasodilator-stimulated phosphoprotein (VASP) localization and cell migration.	PRKD1 VASP	1.26e-05	2	124	2	23846685
Pubmed	The Hyperpolarization-Activated HCN4 Channel is Important for Proper Maintenance of Oscillatory Activity in the Thalamocortical System.	HCN4 HCN2	1.26e-05	2	124	2	30877792
Pubmed	A T-type calcium channel required for normal function of a mammalian mechanoreceptor.	CACNA1I CACNA1H	1.26e-05	2	124	2	12808460
Pubmed	Cav3.2 subunit underlies the functional T-type Ca2+ channel in murine hearts during the embryonic period.	CACNA1H CACNA1G	1.26e-05	2	124	2	14988077
Pubmed	Role of T-type calcium channel subunits in post-myocardial infarction remodelling probed with genetically engineered mice.	CACNA1H CACNA1G	1.26e-05	2	124	2	21622683
Pubmed	Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice.	CACNA1I CACNA1H	1.26e-05	2	124	2	25071191
Pubmed	Mature erythrocyte membrane homeostasis is compromised by loss of the GATA1-FOG1 interaction.	GATA1 ZFPM1	1.26e-05	2	124	2	22279059
Pubmed	Ca(v)3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain.	CACNA1H CACNA1G	1.26e-05	2	124	2	20685979
Pubmed	Whole Exome Sequencing of Hemiplegic Migraine Patients Shows an Increased Burden of Missense Variants in CACNA1H and CACNA1I Genes.	CACNA1I CACNA1H	1.26e-05	2	124	2	36786913
Pubmed	Neuronal Per Arnt Sim (PAS) domain protein 4 (NPAS4) regulates neurite outgrowth and phosphorylation of synapsin I.	SYN1 NPAS4	1.26e-05	2	124	2	23172225
Pubmed	Contribution of postsynaptic T-type calcium channels to parallel fibre-Purkinje cell synaptic responses.	CACNA1I CACNA1G	1.26e-05	2	124	2	26627919
Pubmed	Functional comparison of HCN isoforms expressed in ventricular and HEK 293 cells.	HCN4 HCN2	1.26e-05	2	124	2	12194012
Pubmed	Modulation of Ca(v)3.1 T-type Ca2+ channels by the ran binding protein RanBPM.	RANBP9 CACNA1G	1.26e-05	2	124	2	18801335
Pubmed	Pleiotropic platelet defects in mice with disrupted FOG1-NuRD interaction.	GATA1 ZFPM1	1.26e-05	2	124	2	21989988
Pubmed	Chronic deficit in nitric oxide elicits oxidative stress and augments T-type calcium-channel contribution to vascular tone of rodent arteries and arterioles.	CACNA1H CACNA1G	1.26e-05	2	124	2	23436820
Pubmed	Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction.	GATA1 ZFPM1	1.26e-05	2	124	2	15644435
Pubmed	Deficiency of T-type Ca2+ channels Cav3.1 and Cav3.2 has no effect on angiotensin II-induced hypertension but differential effect on plasma aldosterone in mice.	CACNA1H CACNA1G	1.26e-05	2	124	2	31042060
Pubmed	Global regulation of erythroid gene expression by transcription factor GATA-1.	GATA1 ZFPM1	1.26e-05	2	124	2	15297311
Pubmed	Control of megakaryocyte-specific gene expression by GATA-1 and FOG-1: role of Ets transcription factors.	GATA1 ZFPM1	1.26e-05	2	124	2	12356738
Pubmed	Transgenic rescue of GATA-1-deficient mice with GATA-1 lacking a FOG-1 association site phenocopies patients with X-linked thrombocytopenia.	GATA1 ZFPM1	1.26e-05	2	124	2	14656885
Pubmed	Proteolytic processing of HCN2 and co-assembly with HCN4 in the generation of cardiac pacemaker channels.	HCN4 HCN2	1.26e-05	2	124	2	19574228
Pubmed	HCN2 and HCN4 isoforms self-assemble and co-assemble with equal preference to form functional pacemaker channels.	HCN4 HCN2	1.26e-05	2	124	2	17553794
Pubmed	Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4.	HCN4 HCN2	1.26e-05	2	124	2	12813043
Pubmed	Controlling hematopoiesis through sumoylation-dependent regulation of a GATA factor.	GATA1 ZFPM1	1.26e-05	2	124	2	20064464
Pubmed	X-linked thrombocytopenia caused by a novel mutation of GATA-1.	GATA1 ZFPM1	1.26e-05	2	124	2	11675338
Pubmed	Two pacemaker channels from human heart with profoundly different activation kinetics.	HCN4 HCN2	1.26e-05	2	124	2	10228147
Pubmed	Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits.	NEDD4L SLC45A3	1.26e-05	2	124	2	33045005
Pubmed	Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels.	HCN4 HCN2	1.26e-05	2	124	2	16777944
Pubmed	X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction.	GATA1 ZFPM1	1.26e-05	2	124	2	12200364
Pubmed	Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG.	GATA1 ZFPM1	1.26e-05	2	124	2	9553047
Pubmed	T-type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in the inhibition of proliferation and apoptosis in MCF-7 human breast cancer cells.	CACNA1H CACNA1G	1.26e-05	2	124	2	22469755
Pubmed	Platelet characteristics in patients with X-linked macrothrombocytopenia because of a novel GATA1 mutation.	GATA1 ZFPM1	1.26e-05	2	124	2	11418466
Pubmed	Different distribution of Cav3.2 and Cav3.1 transcripts encoding T-type Ca(2+) channels in the embryonic heart of mice.	CACNA1H CACNA1G	1.26e-05	2	124	2	21079360
Pubmed	INSM1 increases N-myc stability and oncogenesis via a positive-feedback loop in neuroblastoma.	MYCN INSM1	1.26e-05	2	124	2	26456864
Pubmed	The Ca(v)3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice.	CACNA1H CACNA1G	1.26e-05	2	124	2	22886848
Pubmed	Friend of GATA-1-independent transcriptional repression: a novel mode of GATA-1 function.	GATA1 ZFPM1	1.26e-05	2	124	2	17339418
Pubmed	Deletion of T-type calcium channels Cav3.1 or Cav3.2 attenuates endothelial dysfunction in aging mice.	CACNA1H CACNA1G	1.26e-05	2	124	2	29082441
Pubmed	Single-channel properties support a potential contribution of hyperpolarization-activated cyclic nucleotide-gated channels and If to cardiac arrhythmias.	HCN4 HCN2	1.26e-05	2	124	2	15687126
Pubmed	Control of heart rate by cAMP sensitivity of HCN channels.	HCN4 HCN2	1.26e-05	2	124	2	19570998
Pubmed	[Decreased mRNA expressions of T-type channel alpha1H and alpha1G in the sperm of varicocele patients and their implication].	CACNA1H CACNA1G	1.26e-05	2	124	2	22574369
Pubmed	FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation.	GATA1 ZFPM1	1.26e-05	2	124	2	9230307
Pubmed	Blockade of T-type Ca(2+) channels inhibits human ovarian cancer cell proliferation.	CACNA1H CACNA1G	1.26e-05	2	124	2	21438841
Pubmed	A boundary for histone acetylation allows distinct expression patterns of the Ad4BP/SF-1 and GCNF loci in adrenal cortex cells.	NR6A1 NR5A1	1.26e-05	2	124	2	15737622
Pubmed	β-Adrenergic stimulation increases Cav3.1 activity in cardiac myocytes through protein kinase A.	CACNA1H CACNA1G	1.26e-05	2	124	2	22808078
Pubmed	Calcium handling precedes cardiac differentiation to initiate the first heartbeat.	HCN4 CACNA1H CACNA1G	2.90e-05	17	124	3	27725084
Pubmed	Phosphoproteomic analysis of the developing mouse brain.	STRIP1 SNAP91 STRN4 SYN1 IRF2BPL SCRIB SSBP4	3.03e-05	246	124	7	15345747
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	BCL9L IFFO1 DENND1A STRIP1 LATS2 AP2A2 SEC16A STRN4 SH3RF3	3.34e-05	446	124	9	24255178
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	NEDD4L AHCYL2 HCN2 STRIP1 SNAP91 STRN4 SYN1 AGAP2	3.65e-05	347	124	8	17114649
Pubmed	5,6-EET potently inhibits T-type calcium channels: implication in the regulation of the vascular tone.	CACNA1H CACNA1G	3.77e-05	3	124	2	24327205
Pubmed	KCNE2 modulates current amplitudes and activation kinetics of HCN4: influence of KCNE family members on HCN4 currents.	HCN4 HCN2	3.77e-05	3	124	2	12856183
Pubmed	Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions.	GATA1 ZFPM1	3.77e-05	3	124	2	12483298
Pubmed	Differential coregulator requirements for function of the hematopoietic transcription factor GATA-1 at endogenous loci.	GATA1 ZFPM1	3.77e-05	3	124	2	20047963
Pubmed	Differential effect of T-type voltage-gated Ca2+ channel disruption on renal plasma flow and glomerular filtration rate in vivo.	CACNA1H CACNA1G	3.77e-05	3	124	2	24966091
Pubmed	Functional roles of Ca(v)1.3, Ca(v)3.1 and HCN channels in automaticity of mouse atrioventricular cells: insights into the atrioventricular pacemaker mechanism.	HCN4 CACNA1G	3.77e-05	3	124	2	21406960
Pubmed	Polarity Protein Scrib Facilitates Endothelial Inflammatory Signaling.	GATA1 SCRIB	3.77e-05	3	124	2	26205961
Pubmed	Ventricular HCN channels decrease the repolarization reserve in the hypertrophic heart.	HCN4 HCN2	3.77e-05	3	124	2	22652004
Pubmed	Cytoplasmic cAMP-sensing domain of hyperpolarization-activated cation (HCN) channels uses two structurally distinct mechanisms to regulate voltage gating.	HCN4 HCN2	3.77e-05	3	124	2	21187420
Pubmed	Novel insights into the distribution of cardiac HCN channels: an expression study in the mouse heart.	HCN4 HCN2	3.77e-05	3	124	2	21945247
Pubmed	A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by Src kinase.	HCN4 HCN2	3.77e-05	3	124	2	16079136
Pubmed	Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.	HCN4 HCN2	3.77e-05	3	124	2	22006928
Pubmed	ZnT-1 enhances the activity and surface expression of T-type calcium channels through activation of Ras-ERK signaling.	CACNA1H CACNA1G	3.77e-05	3	124	2	22572848
Pubmed	Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage.	GATA1 ZFPM1	3.77e-05	3	124	2	18299398
Pubmed	Growth differentiation factor-15 promotes glutamate release in medial prefrontal cortex of mice through upregulation of T-type calcium channels.	CACNA1I CACNA1G	3.77e-05	3	124	2	27353765
Pubmed	T-type, but not L-type, voltage-gated calcium channels are dispensable for lymphatic pacemaking and spontaneous contractions.	CACNA1H CACNA1G	3.77e-05	3	124	2	31919478
Pubmed	Primary cilia are not required for normal canonical Wnt signaling in the mouse embryo.	DYNC2H1 AXIN2	3.77e-05	3	124	2	19718259
Pubmed	GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis.	GATA1 ZFPM1	3.77e-05	3	124	2	12077323
Pubmed	HCN channels in the mammalian cochlea: Expression pattern, subcellular location, and age-dependent changes.	HCN4 HCN2	3.77e-05	3	124	2	33181864
Pubmed	Differential context-dependent effects of friend of GATA-1 (FOG-1) on mast-cell development and differentiation.	GATA1 ZFPM1	3.77e-05	3	124	2	18063754
Pubmed	Scribble-mediated membrane targeting of PHLPP1 is required for its negative regulation of Akt.	PHLPP1 SCRIB	3.77e-05	3	124	2	21701506
Pubmed	Caveolin-3 regulates protein kinase A modulation of the Ca(V)3.2 (alpha1H) T-type Ca2+ channels.	CACNA1H CACNA1G	3.77e-05	3	124	2	21084288
Pubmed	Global genetic deletion of CaV3.3 channels facilitates anaesthetic induction and enhances isoflurane-sparing effects of T-type calcium channel blockers.	CACNA1I CACNA1G	3.77e-05	3	124	2	33299036
Pubmed	Biallelic expression of HRAS and MUCDHL in human and mouse.	DUSP8 CDHR5	3.77e-05	3	124	2	12589428
Pubmed	The upregulation of Gata transcription factors family and FOG-1 in expanded and differentiated cord blood-derived CD34+ hematopoietic stem cells to megakaryocyte lineage during co-culture with cord blood mesenchymal stem cells.	GATA1 ZFPM1	3.77e-05	3	124	2	35690555
Cytoband	17q23-q24	AXIN2 SMARCD2	2.17e-05	3	124	2	17q23-q24
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	NUDT19 ZNF444 ZNF628 ETV2 GRIN2D KIRREL2 ZNF865 STRN4 MAMSTR TPRX1 VASP CNOT3 NOVA2	2.19e-05	1192	124	13	chr19q13
Cytoband	Ensembl 112 genes in cytogenetic band chr1p33	FOXD2 DMBX1 FOXE3	6.17e-04	61	124	3	chr1p33
GeneFamily	Collagens	COL7A1 COL15A1 COL17A1 COL5A3	7.98e-05	46	90	4	490
GeneFamily	Basic helix-loop-helix proteins	MYCN BHLHA9 BHLHE23 HES4 NPAS4	2.22e-04	110	90	5	420
GeneFamily	Calcium voltage-gated channel subunits	CACNA1I CACNA1H CACNA1G	2.85e-04	26	90	3	253
GeneFamily	Cyclic nucleotide gated channels	HCN4 HCN2	1.07e-03	10	90	2	250
GeneFamily	Zinc fingers C2H2-type\|SNAG transcriptional repressors	SCRT1 INSM1	1.07e-03	10	90	2	1259
GeneFamily	Forkhead boxes	FOXD2 FOXD1 FOXE3	1.27e-03	43	90	3	508
GeneFamily	Nuclear hormone receptors	ESRRA NR6A1 NR5A1	1.86e-03	49	90	3	71
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	SH2B3 PHLPP1 PRKD1 DNM1 AGAP2	3.67e-03	206	90	5	682
GeneFamily	Protein phosphatase catalytic subunits\|STRIPAK complex	STRIP1 STRN4	4.39e-03	20	90	2	1371
Coexpression	BENPORATH_ES_WITH_H3K27ME3	FOXD2 HCN4 FRAT1 ADAM15 DUSP8 IRX3 ZFPM1 GRIN2D HOXB3 ADRB1 BHLHE23 LBX1 EGR4 TMEM132E ELAVL3 CACNA1G PRKD1 SSBP4 PRRT1 NPAS4 NOVA2 AGAP2 FOXE3	2.36e-09	1115	124	23	M10371
Coexpression	MIKKELSEN_MCV6_HCP_WITH_H3K27ME3	COL15A1 SCRT1 BHLHA9 C1QL4 HMX1 BHLHE23 GRID2IP LBX1 MIXL1 TMEM132E KCNQ4 CACNA1I CACNA1G SH3RF3 FOXE3	2.64e-09	438	124	15	M1954
Coexpression	MIKKELSEN_MCV6_HCP_WITH_H3K27ME3	COL15A1 SCRT1 BHLHA9 C1QL4 HMX1 BHLHE23 GRID2IP LBX1 MIXL1 TMEM132E KCNQ4 CACNA1I CACNA1G SH3RF3 FOXE3	2.81e-09	440	124	15	MM832
Coexpression	MIKKELSEN_NPC_HCP_WITH_H3K27ME3	COL15A1 SCRT1 HCN2 DMBX1 HOXB3 BHLHE23 LBX1 MIXL1 TMEM132E FOXE3	5.93e-06	345	124	10	M2009
Coexpression	MIKKELSEN_NPC_HCP_WITH_H3K27ME3	COL15A1 SCRT1 HCN2 DMBX1 HOXB3 BHLHE23 LBX1 MIXL1 TMEM132E FOXE3	6.24e-06	347	124	10	MM860
Coexpression	MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3	SCRT1 KIRREL2 HMX1 HCN2 DMBX1 LBX1 TMEM132E ELAVL3 CACNA1I FOXE3	6.73e-06	350	124	10	M1949
Coexpression	MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3	SCRT1 KIRREL2 HMX1 HCN2 DMBX1 LBX1 TMEM132E ELAVL3 CACNA1I FOXE3	8.00e-06	357	124	10	MM828
Coexpression	BENPORATH_SUZ12_TARGETS	FOXD2 CEBPD HCN4 INSM1 IRX3 GRIN2D HOXB3 ADRB1 BHLHE23 LBX1 EGR4 TMEM132E ELAVL3 CACNA1G NPAS4 FOXE3	3.10e-05	1035	124	16	M9898
Coexpression	GSE16450_CTRL_VS_IFNA_6H_STIM_MATURE_NEURON_CELL_LINE_UP	DUSP8 GATA1 AHCYL2 ZDHHC8 KCNQ4 PHLPP1 SH3RF3	4.65e-05	199	124	7	M7420
Coexpression	NABA_COLLAGENS	COL7A1 COL15A1 COL17A1 COL5A3	5.10e-05	43	124	4	MM17060
Coexpression	NABA_COLLAGENS	COL7A1 COL15A1 COL17A1 COL5A3	5.59e-05	44	124	4	M3005
CoexpressionAtlas	EB amniotic fluid MSC_vs_EB blastocyst-Confounder_removed-fold2.0_adjp0.05	SCRT1 COL17A1 PRR36 DUSP8 INSM1 C1QL4 GRIN2D KIRREL2 AXIN2 HOXB3 SNAP91 EGR4 HES4 ELAVL3 SLAIN1 NOVA2 AGAP2	6.34e-07	727	119	17	PCBC_ratio_EB amniotic fluid MSC_vs_EB blastocyst_cfr-2X-p05
CoexpressionAtlas	Progenitor-Cell-Biology-Consortium_induced-Ectoderm_top-relative-expression-ranked_500	SALL3 INSM1 IGDCC3 NR6A1 KIRREL2 FOXI3 DMBX1 SNAP91 KCNQ4 HES4 NR5A1 FOXE3	2.24e-05	495	119	12	PCBC_ECTO_500
CoexpressionAtlas	cerebral cortex	SCRT1 SALL3 HCN4 PRR36 DUSP8 IGDCC3 GRIN2D HMX1 HCN2 SNAP91 EGR4 TMEM132E SYN1 ELAVL3 CACNA1I CACNA1G PRRT1 DNM1 NPAS4 NOVA2 AGAP2	4.16e-05	1428	119	21	cerebral cortex
CoexpressionAtlas	Progenitor-Cell-Biology-Consortium_induced-Ectoderm_fromBlastocyst-derived-humanEmbryonicStemCells_top-relative-expression-ranked_500	INSM1 IGDCC3 NR6A1 KIRREL2 FOXI3 DMBX1 AXIN2 SNAP91 KCNQ4 NPAS4 FOXE3	9.38e-05	487	119	11	PCBC_ECTO_blastocyst_500
CoexpressionAtlas	Progenitor-Cell-Biology-Consortium_induced-Ectoderm_from_inducedPluripotentialStemCells_derived from_from_fibroblast_top-relative-expression-ranked_500	SALL3 INSM1 IGDCC3 NR6A1 KIRREL2 FOXI3 DMBX1 SNAP91 HES4 NR5A1 FOXE3	1.12e-04	497	119	11	PCBC_ECTO_fibroblast_500
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_500	SALL3 PRR36 DYNC2H1 INSM1 IGDCC3 IRX3 DMBX1 SYN1 PHLPP1 ELAVL3 FOXD1	1.14e-04	498	119	11	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_500
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate\|5w / Sample Type, Dataset, Time_group, and Cell type.	SCRT1 ATN1 NEDD4L INSM1 ELAVL3 SLAIN1 NOVA2	1.50e-06	200	124	7	c92e4fc0442404481fcac623d691dae6215b852d
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	INSM1 ADAMTS13 ADRB1 EGR4 CACNA1H HYDIN	3.04e-06	143	124	6	5fb5a4ea93e5cce55d427e3b4a50a979504fad3c
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL15A1 ADAM15 IRX3 CASKIN2 SH3RF3 NOVA2	7.69e-06	168	124	6	37249f38f8f04ec5743097259de67b106ca2b02f
ToppCell	PCW_13-14-Neuronal-Neuronal_postreplicative-neuro_neuronal_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	INSM1 HCN2 SNAP91 TMEM132E ELAVL3 NPAS4	1.10e-05	179	124	6	af0b54c9ea0b6e4210f22dbb6e88ecd3276a5f86
ToppCell	Adult-Mesenchymal-pericyte_cell-D122\|Adult / Lineage, Cell type, age group and donor	COL7A1 COL5A3 KCNQ4 HES4 CACNA1H SH3RF3	1.25e-05	183	124	6	fc31a43a637423cb3bb9aa184a3a889a0b9aaea6
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCL9L ATN1 IRX3 TESK1 KLF16 EIF3F	1.37e-05	186	124	6	bd1185592aedebccd1007dbf2dd2f549fcdf9f42
ToppCell	Adult-Mesenchymal-pericyte_cell\|Adult / Lineage, Cell type, age group and donor	COL7A1 COL5A3 KCNQ4 HES4 CACNA1H SH3RF3	1.41e-05	187	124	6	62759efb660179402fb574ce5701c89a2e17bcfe
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_neural-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	COL17A1 INSM1 IGDCC3 ATP1A1-AS1 LBX1 PWWP3A	1.46e-05	188	124	6	e239bcdbd210a398a5850cb6fbf171d402f45a4f
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_neural-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SCRT1 INSM1 IGDCC3 HOXB3 ELAVL3 AGAP2	1.74e-05	194	124	6	4e93bd903cddfd0c8f220b6a35b449895de4119b
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_neural-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SCRT1 NEDD4L INSM1 IGDCC3 NPAS4 AGAP2	1.90e-05	197	124	6	b4554353c56e220bae31ee3c8aa222674dd0b18c
ToppCell	proximal-Epithelial-Neuroendocrine\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	INSM1 IGDCC3 HCN2 SNAP91 EGR4 ELAVL3	1.95e-05	198	124	6	5dea6078488d584513c0bdbf5bba54877310b54a
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal-ventral_progenitors_and_neurons_2\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	SCRT1 NEDD4L INSM1 SYN1 ELAVL3 NOVA2	1.95e-05	198	124	6	b73b9feb82997b654718aa27f33ca7b454214802
ToppCell	proximal-Epithelial-Neuroendocrine-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	INSM1 IGDCC3 HCN2 SNAP91 EGR4 ELAVL3	1.95e-05	198	124	6	00ccf3020667cf2130bc354b441b65c0b1b0e862
ToppCell	proximal-3-Epithelial-Neuroendocrine\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	INSM1 IGDCC3 HCN2 SNAP91 EGR4 ELAVL3	1.95e-05	198	124	6	a6bc043faf68468d46bac441cf7447c236c7bae4
Drug	1,3-dioxoisoindoline-5-carboxamide	CACNA1I CACNA1H CACNA1G	1.54e-07	3	123	3	CID010679219
Drug	fullerene C60	HJV COL7A1 ADAM19 CEBPD IFFO1 BEAN1 LIX1L IRX3 NIBAN2 ZFPM1 GRIN2D AXIN2 ADRB1 LATS2 MIXL1 CASKIN2 TMEM259 IGHMBP2 STRN4 SYN1 PWWP3A IRF2BPL CACNA1I CACNA1G SH3RF3	3.68e-07	1498	123	25	ctd:C069837
Drug	Flunarizine	CACNA1I CACNA1H CACNA1G	1.53e-06	5	123	3	DB04841
Drug	3,4-dihydroquinazoline	CACNA1I CACNA1H CACNA1G	3.04e-06	6	123	3	CID000583065
Drug	HCNs	HCN4 HCN2 CACNA1I CACNA1H	3.67e-06	20	123	4	CID006857665
Drug	LY215840	CACNA1I CACNA1H CACNA1G	5.30e-06	7	123	3	CID000132049
Drug	KW-3049	ADRB1 SNAP91 CACNA1I CACNA1H CACNA1G	7.40e-06	50	123	5	CID000002324
Drug	Sulfameter [651-06-9]; Up 200; 14.2uM; HL60; HT_HG-U133A	ADAM19 COL17A1 ATN1 NR6A1 HOXB3 CACNA1G NOVA2 AGAP2	1.20e-05	197	123	8	2712_UP
Drug	Cinnarizine	CACNA1I CACNA1H CACNA1G	1.26e-05	9	123	3	DB00568
Drug	rufinamide	KCNQ4 CACNA1I CACNA1H CACNA1G	1.74e-05	29	123	4	CID000129228
Drug	ZD7288	HCN2 CACNA1I CACNA1H	1.80e-05	10	123	3	CID000123983
Drug	loperamide	HCN4 GRIN2D CACNA1I CACNA1H CACNA1G PRKD1	2.29e-05	105	123	6	CID000003954
Drug	Mibefradil	CACNA1I CACNA1H CACNA1G	2.46e-05	11	123	3	DB01388
Drug	EBNs	CACNA1I CACNA1H CACNA1G	2.46e-05	11	123	3	CID000150695
Drug	themisone	CACNA1I CACNA1H CACNA1G	3.27e-05	12	123	3	CID000016235
Drug	AC1L2VU3	CACNA1I CACNA1H CACNA1G	3.27e-05	12	123	3	CID000129572
Drug	Go7874	SNAP91 PRKD1 DNM1	3.27e-05	12	123	3	CID005327863
Drug	Mibefradil	CACNA1I CACNA1H CACNA1G	4.23e-05	13	123	3	ctd:D020748
Drug	tetralol	CACNA1I CACNA1H CACNA1G	4.23e-05	13	123	3	CID000010747
Drug	lactofen	EVPL IRX3 CACNA1I CACNA1H CACNA1G	7.83e-05	81	123	5	CID000062276
Drug	pentasulfane	CACNA1I CACNA1H CACNA1G	8.18e-05	16	123	3	CID000448216
Drug	AC1L9MJT	COL7A1 COL17A1 GATA1 EVPL HMX1 HCN2 TAF4	8.47e-05	192	123	7	CID000448959
Drug	zatebradine	HCN4 HCN2	8.65e-05	3	123	2	ctd:C043636
Drug	SureCN2398996	CACNA1I CACNA1H	8.65e-05	3	123	2	CID010220069
Drug	N-desmethylmethsuximide	CACNA1I CACNA1H	8.65e-05	3	123	2	CID000092154
Drug	dihydropyridine	ADRB1 SNAP91 IGHMBP2 CACNA1I CACNA1H CACNA1G PRKD1	8.75e-05	193	123	7	CID000104822
Drug	W-13, hydrochloride; Up 200; 10uM; MCF7; HG-U133A	COL7A1 IFFO1 NR6A1 CASKIN2 TMEM259 CACNA1I DNM1	9.03e-05	194	123	7	440_UP
Drug	Roxarsone [121-19-7]; Up 200; 15.2uM; MCF7; HT_HG-U133A	COL17A1 HCN4 NR6A1 HOXB3 TMEM259 NOVA2 FOXE3	9.33e-05	195	123	7	3511_UP
Drug	Aminocaproic acid [60-32-2]; Up 200; 30.4uM; HL60; HT_HG-U133A	FOXD2 ATN1 TESK1 AP2A2 FGB PWWP3A CACNA1I	9.63e-05	196	123	7	3122_UP
Drug	Zonisamide	CACNA1I CACNA1H CACNA1G	9.90e-05	17	123	3	DB00909
Drug	9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2; Up 200; 10uM; MCF7; HT_HG-U133A	ZNF444 PRR36 ADAMTS13 AHCYL2 AP2A2 IGHMBP2 CACNA1H	9.94e-05	197	123	7	7500_UP
Drug	alpha-estradiol; Up 200; 0.01uM; MCF7; HT_HG-U133A	ATN1 NEDD4L PRR36 ADAMTS13 ELAVL3 CACNA1I NOVA2	9.94e-05	197	123	7	5207_UP
Drug	Dinoprost trometamol [38362-01-5]; Down 200; 8.4uM; MCF7; HT_HG-U133A	COL7A1 PRR36 FBRS NR6A1 TMEM259 IGHMBP2 CACNA1H	9.94e-05	197	123	7	3308_DN
Drug	Vancomycin hydrochloride [1404-93-9]; Up 200; 2.6uM; HL60; HT_HG-U133A	ZNF444 COL17A1 ESRRA TESK1 CACNA1I CACNA1G AGAP2	1.06e-04	199	123	7	2498_UP
Drug	Benzathine benzylpenicillin [5928-84-7]; Up 200; 4.2uM; MCF7; HT_HG-U133A	PRR36 ADAM15 AP2A2 TMEM259 IGHMBP2 CACNA1I CNOT3	1.06e-04	199	123	7	4140_UP
Disease	Congenital dyserythropoietic anemia	GATA1 CDAN1	2.47e-04	6	121	2	cv:C0002876
Disease	benign neoplasm (implicated_via_orthology)	LATS2 SCRIB	4.59e-04	8	121	2	DOID:0060072 (implicated_via_orthology)
Disease	non-high density lipoprotein cholesterol measurement	SH2B3 ADAM15 ZFPM1 HOXB3 ADRB1 MAMSTR FGB HYDIN VASP DERPC	7.27e-04	713	121	10	EFO_0005689
Disease	kidney cancer (implicated_via_orthology)	LATS2 SCRIB	8.95e-04	11	121	2	DOID:263 (implicated_via_orthology)
Disease	developmental and epileptic encephalopathy (implicated_via_orthology)	KCNQ4 DNM1	1.26e-03	13	121	2	DOID:0112202 (implicated_via_orthology)
Disease	Ischemic stroke, tissue plasminogen activator measurement	SH2B3 FGB	1.69e-03	15	121	2	EFO_0004791, HP_0002140
Disease	Ischemic stroke, plasminogen activator inhibitor 1 measurement	SH2B3 FGB	1.93e-03	16	121	2	EFO_0004792, HP_0002140
Disease	major depressive disorder (is_marker_for)	GATA1 SYN1	2.18e-03	17	121	2	DOID:1470 (is_marker_for)
Disease	factor XI measurement, Ischemic stroke	SH2B3 FGB	2.18e-03	17	121	2	EFO_0004694, HP_0002140
Disease	carcinoma (implicated_via_orthology)	SALL3 LATS2 SCRIB	2.34e-03	64	121	3	DOID:305 (implicated_via_orthology)
Disease	Neutropenia	GATA1 SMARCD2	3.33e-03	21	121	2	C0027947

Protein segments in the cluster

Peptide	Gene	Start	Entry
ASGCLARPGPPPSPG	ADRB1	411	P08588
LPGPPGPPGSFLSNS	COL17A1	886	Q9UMD9
PSGDLPGPGAGIPPL	ADAM15	831	Q13444
PGGASPLRPPGAGPQ	ADAM19	876	Q9H013
LSAPGLPGPGQPAGP	DUSP8	491	Q13202
GDTGASPPPPAGPSL	BHLHA9	146	Q7RTU4
GTPGPGGDLPAAPAP	BHLHE23	41	Q8NDY6
GPRGPGPDGAPASVP	C1QL4	36	Q86Z23
SPPGLGAQPLPGHLP	ATN1	316	P54259
LPPGGKLPPAAASPG	AXIN2	481	Q9Y2T1
AAPPGPPLSGGLSPD	AGAP2	116	Q99490
GPAGPALPNGPLLGT	ELAVL3	16	Q14576
AAAAAAPAPPPPAGG	SNAP91	361	O60641
GPASPGGAPEPPAAA	CDHR5	751	Q9HBB8
PGASAALPGRPGGPP	CDAN1	76	Q8IWY9
SPGAPLKGRPPSPGF	ADAMTS13	51	Q76LX8
LLGLGAAPPAPAGPP	AP2A2	661	O94973
PRPPAPPSSAAGVGG	ATP1A1-AS1	26	Q5TC04
NGVPAPAAPPSALGP	CNOT3	341	O75175
AAPASGPPAPPGLAA	RANBP9	96	Q96S59
RGPALPGAGSGLPAP	HJV	131	Q6ZVN8
SPAPPGPAPAAGAGA	FOXD1	86	Q16676
PPPAGPLLNGAPAGE	NIBAN2	666	Q96TA1
FGAGATAGNIPPPPP	DAZAP2	116	Q15038
GLPPPAATAAAPGAP	FOXI3	16	A8MTJ6
SGPGPAPFLAPVAAP	PRKD1	31	Q15139
PPPAASGPGPGAAAA	KLF16	61	Q9BXK1
CAGLAAAPPPPDGGP	IGDCC3	776	Q8IVU1
AAPPPPDGGPGLLSE	IGDCC3	781	Q8IVU1
APGPGLALEPPPGLA	NUDT19	151	A8MXV4
GPPGAGLAFPPPAAG	LATS2	296	Q9NRM7
RGPAPGPPPAGSALG	DNM1	796	Q05193
GPPPAGSALGGAPPV	DNM1	801	Q05193
GLLGSPLPPGAPLPG	KCNQ4	46	P56696
AGPLPSQIPPTAPGG	FCRL6	336	Q6DN72
LLLFPSGPGGPSDPP	KIFC1	331	Q9BW19
APSLRPAPPPISGGG	FGB	56	P02675
PPGTGALPPAAPSGR	IRF2BPL	521	Q9H1B7
SPAPGGPPGAPTELL	EVPL	361	Q92817
PAPPPPLLGFSGALA	HMX1	311	Q9NP08
PAAPPPGALGLPAAA	ZFPM1	841	Q8IX07
APGLPLPPGAAGSPA	LIX1L	61	Q8IVB5
APFPAGSDALLPGPP	EGR4	231	Q05215
PPPPPGALGSFALAA	NOVA2	346	Q9UNW9
AGGGPEPLPLPPARS	CASKIN2	681	Q8WXE0
PSPAPPGARGGLGLP	HCN4	941	Q9Y3Q4
SGGLGPALPAASPPP	TENT4A	41	Q5XG87
GDLPPAPLSPAGPAA	IFFO1	36	Q0D2I5
LPAPANGPAGPGPEA	NTN3	161	O00634
AAPPGLPPAAAGPGK	PARP14	986	Q460N5
PGPGPGPGPASLFLA	NPAS4	201	Q8IUM7
PRTGALPGPGPLSNP	DERPC	131	P0CG12
PFPGPLLGSPTGSFP	GATA1	381	P15976
ATLSRGPPPPVGPAG	GAK	341	O14976
AAPGQPLPPHGKPLG	DYNC2H1	2586	Q8NCM8
LPGSPGKTAPLPGPA	CEMP1	31	Q6PRD7
PGLPPGLPPAVSFGS	FBRS	26	Q9HAH7
GLGASGPPIPPPALF	HYDIN	2601	Q4G0P3
PPSLGVLPAPDGGPG	GRID2IP	76	A4D2P6
PPSTPALSGAPPGGA	CACNA1G	536	O43497
LPGGPARPLGPGPAA	CEBPD	101	P49716
ALPGPALPGPFPGGR	EIF3F	76	O00303
GSPLLPAPPAGLAPA	DMBX1	336	Q8NFW5
GPAGGGASPPRPPDA	FBXL17	231	Q9UF56
LGPPAPAPGPRAGLS	CACNA1I	2046	Q9P0X4
GGYADPLPPPAGPSL	HOXB3	356	P14651
PPGGDPSSAPGPALL	BCL9L	366	Q86UU0
LPAAPRAGPQGPGGP	HES4	201	Q9HCC6
PASPLGPAGGLPHAP	TMEM259	566	Q4ZIN3
LEALSGGPPLGSGPP	MAMSTR	376	Q6ZN01
PAGPFGAPPASLGPA	DENND1A	851	Q8TEH3
ASPCGPPGAPLRAPG	FRAT1	61	Q92837
GEAPGGGLFLPPPSP	KIRREL2	616	Q6UWL6
PPGLALGERGPPGPS	COL7A1	2016	Q02388
VLPPGAPKAPGAGAL	LBX1	236	P52954
PAPLGPGPIPAAGSE	ETV2	111	O00321
GAGPPSGLLPLPGPD	BEAN1	221	Q3B7T3
SGLLPLPGPDPGPRG	BEAN1	226	Q3B7T3
GAPPPGPAALVGASP	CACNA1H	16	O95180
PGPPGPPAILGAAVA	COL15A1	1101	P39059
GPAAGAPPPGCATLP	PRRT1	91	Q99946
AAPSAPGPAPSQLPG	SALL3	246	Q9BXA9
PFPGPFPAGPLAVAG	ESRRA	171	P11474
GGLPAAPLAGPALPA	HCN2	796	Q9UL51
GPPGPPGAPAELHGL	COL5A3	1481	P25940
PSLPPEAGGPLGNPA	PCARE	1146	A6NGG8
GAEAARGPGPGPPLP	INSM1	176	Q01101
PPGAGGSPPGAAVAP	IRX3	366	P78415
GLALPAYGAPPPGPA	FOXD2	271	O60548
GSAGFLEPPAALPPP	NR6A1	16	Q15406
AGAAPSPGPGPGPRE	PWWP3A	321	Q2TAK8
PPAPGTPTGLPKGAA	TAF4	391	O00268
VAGGPGAPPAARPPA	SYN1	536	P17600
PPAGPLGDFGAPALP	NR5A1	156	Q13285
GSGPGPAPALAPEPS	TRIM47	86	Q96LD4
PVPGPGSGPAAALSP	AHCYL2	61	Q96HN2
GAGGPAAPAPPQLSP	SCRT1	331	Q9BWW7
GAGPPGSALPAPEAP	TMEM132E	841	Q6IEE7
ATPAPGALDPGPSPG	PRR36	1206	Q9H6K5
AVAPSGPPPSPLAGA	FOXE3	21	Q13461
PPPGAPRAAAGLLPG	STRIP1	31	Q5VSL9
GAGTPPGAAAAPPSP	SLAIN1	146	Q8ND83
PASPPPLGGGAPVRT	SCRIB	1446	Q14160
VGAGGSGLLPPPPAL	SLC45A3	446	Q96JT2
VAAALGAPPPPAGPG	SMARCD2	21	Q92925
PPAGSPFGAAAPLRP	SMARCD2	91	Q92925
GRLPASGLPGPLPPG	TNRC18	36	O15417
AGPGAGLPPPRAPAL	TNRC18	2056	O15417
GSPGSPGPALRPLPA	ZNF444	231	Q8N0Y2
GLGAPAGAPGPLPAP	ZNF865	176	P0CJ78
LLPPAPGGLQPPDGS	ZNF865	726	P0CJ78
APIPGPISGPFSGPN	TPRX1	161	Q8N7U7
PGSLPGLAPILGPGS	TPRX1	296	Q8N7U7
AAALLPAPPAGPGPA	MIXL1	36	Q9H2W2
PAPPAGPGPATFAGF	MIXL1	41	Q9H2W2
AAPAGAPGVAPPRPG	MYCN	226	P04198
PALGFLEPSGPGLPP	SEC16A	1991	O15027
PGGSPPARPIPGQSA	SH3RF3	131	Q8TEJ3
AALGPPAGTGGPAPL	IGHMBP2	791	P38935
PPAGLPGSQPLLPGA	SSBP4	166	Q9BWG4
PGPGPAAPGLPKARS	SH2B3	106	Q9UQQ2
GARGPEGSLLPSPPP	TACC2	86	O95359
ALPGPGPPAVGPSAE	TESK1	451	Q15569
GPLPPGEAGLPAPST	TET3	306	O43151
PGLARLGPATGPPGP	ZDHHC8	726	Q9ULC8
VPPARSAPGAFGGPP	PHLPP1	281	O60346
SAPGAFGGPPRAPPA	PHLPP1	286	O60346
AAPVSAPAPGPGPAG	STRN4	31	Q9NRL3
AAHGAGGGPPPAPPL	VASP	196	P50552
LAPPPSGPASGPAGL	ZNF628	1001	Q5EBL2
PGGAPTPALGPSAPQ	KIAA1522	836	Q9P206
AVNGFDPAPPPPGLG	NDEL1	316	Q9GZM8
GAPGEPPLLPGGAPL	GRIN2D	286	O15399
SLGLALPPPPASPGS	NEDD4L	286	Q96PU5