Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	KRAB	ZNF157 POGK ZNF254 ZNF267 ZNF880 ZNF215 ZNF699 ZNF829 ZNF587B ZNF77 ZNF17 ZNF716 ZNF852 ZNF732 ZNF728 ZNF197 ZNF814 ZNF534 ZNF528 ZNF304	6.81e-12	358	147	20	PS50805
Domain	KRAB	ZNF157 POGK ZNF254 ZNF267 ZNF880 ZNF215 ZNF699 ZNF829 ZNF587B ZNF77 ZNF17 ZNF716 ZNF852 ZNF732 ZNF728 ZNF197 ZNF814 ZNF534 ZNF528 ZNF304	6.81e-12	358	147	20	PF01352
Domain	KRAB	ZNF157 POGK ZNF254 ZNF267 ZNF880 ZNF215 ZNF699 ZNF829 ZNF587B ZNF77 ZNF17 ZNF716 ZNF852 ZNF732 ZNF728 ZNF197 ZNF814 ZNF534 ZNF528 ZNF304	1.18e-11	369	147	20	SM00349
Domain	KRAB	ZNF157 POGK ZNF254 ZNF267 ZNF880 ZNF215 ZNF699 ZNF829 ZNF587B ZNF77 ZNF17 ZNF716 ZNF852 ZNF732 ZNF728 ZNF197 ZNF814 ZNF534 ZNF528 ZNF304	1.24e-11	370	147	20	IPR001909
Domain	-	ZNF157 ZNF618 ZNF254 ZNF267 ZNF880 ZNF215 ZNF699 ZNF829 ZNF587B ZNF77 ZNF17 ZBTB7A ZNF716 ZNF852 ZNF732 ZNF728 ZNF197 ZNF814 ZNF534 ZNF528 PRDM14 ZNF304	1.75e-08	679	147	22	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF157 ZNF618 ZNF254 ZNF267 ZNF880 ZNF215 ZNF699 ZNF829 ZNF587B ZNF77 ZNF17 ZBTB7A ZNF716 ZNF852 ZNF732 ZNF728 ZNF197 ZNF814 ZNF534 ZNF528 PRDM14 ZNF304	2.58e-08	694	147	22	IPR013087
Domain	zf-C2H2	ZNF157 ZNF254 ZNF267 ZNF880 ZNF215 ZNF699 ZNF829 ZNF587B ZNF77 ZNF17 ZBTB7A ZNF716 ZNF852 ZNF732 ZNF728 ZNF197 ZNF814 ZNF534 ZNF528 PRDM14 ZNF304	1.18e-07	693	147	21	PF00096
Domain	ZINC_FINGER_C2H2_2	ZNF157 ZNF618 ZNF254 ZNF267 ZNF880 ZNF215 ZNF699 ZNF829 ZNF587B ZNF77 ZNF17 ZBTB7A ZNF716 ZNF852 ZNF732 ZNF728 ZNF197 ZNF814 ZNF534 ZNF528 PRDM14 ZNF304	1.78e-07	775	147	22	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF157 ZNF618 ZNF254 ZNF267 ZNF880 ZNF215 ZNF699 ZNF829 ZNF587B ZNF77 ZNF17 ZBTB7A ZNF716 ZNF852 ZNF732 ZNF728 ZNF197 ZNF814 ZNF534 ZNF528 PRDM14 ZNF304	1.86e-07	777	147	22	PS00028
Domain	Znf_C2H2-like	ZNF157 ZNF618 ZNF254 ZNF267 ZNF880 ZNF215 ZNF699 ZNF829 ZNF587B ZNF77 ZNF17 ZBTB7A ZNF716 ZNF852 ZNF732 ZNF728 ZNF197 ZNF814 ZNF534 ZNF528 PRDM14 ZNF304	2.81e-07	796	147	22	IPR015880
Domain	Znf_C2H2	ZNF157 ZNF618 ZNF254 ZNF267 ZNF880 ZNF215 ZNF699 ZNF829 ZNF587B ZNF77 ZNF17 ZBTB7A ZNF716 ZNF852 ZNF732 ZNF728 ZNF197 ZNF814 ZNF534 ZNF528 PRDM14 ZNF304	3.40e-07	805	147	22	IPR007087
Domain	ZnF_C2H2	ZNF157 ZNF618 ZNF254 ZNF267 ZNF880 ZNF215 ZNF699 ZNF829 ZNF587B ZNF77 ZNF17 ZBTB7A ZNF716 ZNF852 ZNF732 ZNF728 ZNF197 ZNF814 ZNF534 ZNF528 PRDM14 ZNF304	3.62e-07	808	147	22	SM00355
Domain	zf-C2H2_6	ZNF157 ZNF267 ZNF880 ZNF699 ZNF77 ZNF17 ZNF852 ZNF732 ZNF728 ZNF197 ZNF814	3.96e-05	314	147	11	PF13912
Domain	ADAM_Cys-rich	ADAM9 ADAM7 ADAMTS5 ADAMTS14	5.62e-05	27	147	4	IPR006586
Domain	ACR	ADAM9 ADAM7 ADAMTS5 ADAMTS14	5.62e-05	27	147	4	SM00608
Domain	Pep_M12B_propep	ADAM9 ADAM7 ADAMTS5 ADAMTS14	2.45e-04	39	147	4	PF01562
Domain	Peptidase_M12B_N	ADAM9 ADAM7 ADAMTS5 ADAMTS14	2.45e-04	39	147	4	IPR002870
Domain	DISINTEGRIN_1	ADAM9 ADAM7 ADAMTS5 ADAMTS14	2.70e-04	40	147	4	PS00427
Domain	Reprolysin	ADAM9 ADAM7 ADAMTS5 ADAMTS14	2.70e-04	40	147	4	PF01421
Domain	ADAM_MEPRO	ADAM9 ADAM7 ADAMTS5 ADAMTS14	2.70e-04	40	147	4	PS50215
Domain	DISINTEGRIN_2	ADAM9 ADAM7 ADAMTS5 ADAMTS14	2.70e-04	40	147	4	PS50214
Domain	Peptidase_M12B	ADAM9 ADAM7 ADAMTS5 ADAMTS14	2.70e-04	40	147	4	IPR001590
Domain	Disintegrin_dom	ADAM9 ADAM7 ADAMTS5 ADAMTS14	2.97e-04	41	147	4	IPR001762
Domain	-	ADAM9 ADAM7 ADAMTS5 PAPPA ADAMTS14	4.47e-04	81	147	5	3.40.390.10
Domain	MetalloPept_cat_dom	ADAM9 ADAM7 ADAMTS5 PAPPA ADAMTS14	4.47e-04	81	147	5	IPR024079
Domain	Na/ntran_symport_orphan	SLC6A17 SLC6A20	6.06e-04	5	147	2	IPR002438
Domain	ACTININ_2	SPTBN2 LCP1 MACF1	7.54e-04	23	147	3	PS00020
Domain	ACTININ_1	SPTBN2 LCP1 MACF1	7.54e-04	23	147	3	PS00019
Domain	Actinin_actin-bd_CS	SPTBN2 LCP1 MACF1	7.54e-04	23	147	3	IPR001589
Domain	ZINC_PROTEASE	ADAM9 ADAMTS5 ACE2 PAPPA ADAMTS14	1.06e-03	98	147	5	PS00142
Domain	Plakophilin/d_Catenin	PKP1 CTNND2	1.26e-03	7	147	2	IPR028435
Domain	TSP_1	CILP ADAMTS5 CCN1 ADAMTS14	1.53e-03	63	147	4	PF00090
Domain	TSP1	CILP ADAMTS5 CCN1 ADAMTS14	1.72e-03	65	147	4	SM00209
Domain	TSP1_rpt	CILP ADAMTS5 CCN1 ADAMTS14	1.72e-03	65	147	4	IPR000884
Domain	TSP1	CILP ADAMTS5 CCN1 ADAMTS14	1.72e-03	65	147	4	PS50092
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	DCAF1 GEMIN5 PTBP1 MPRIP ARHGEF40 TMTC3 UTP20 AKAP13	2.79e-06	202	149	8	33005030
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	ATRN ZNF618 SPTBN2 COPB2 PIWIL2 RYR1 IGF2BP3 AGL UTP20 AKAP13 RPE65 FBN3 RAI1 ZNF304	3.74e-06	736	149	14	29676528
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	DCAF1 ATRN ADAM9 NOL11 GEMIN5 ASPHD2 NCSTN DCLRE1B PTBP1 CMC2 ZNF587B NAA35 TMTC3 TMEM9 GLG1 FDFT1 DCBLD2 TPI1	4.33e-06	1203	149	18	29180619
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DCAF1 CORO1C COPB2 NOL11 GEMIN5 PTBP1 MPRIP CDC45 PRKRA CSDE1 NAA35 ARHGEF40 PSME4 PKP1 MACF1 UTP20 AKAP13 PRR14L TPI1	5.71e-06	1353	149	19	29467282
Pubmed	Temporal Regulation of ESCO2 Degradation by the MCM Complex, the CUL4-DDB1-VPRBP Complex, and the Anaphase-Promoting Complex.	DCAF1 CDC45 ESCO2	1.24e-05	11	149	3	30100344
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF267 ZNF699 ZNF587B ZNF77 ZNF17 ZNF728 ZNF197	1.39e-05	181	149	7	37372979
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	ADAM9 COPB2 NCSTN DNAJB14 FANCD2 CSDE1 NAA35 ARHGEF40 TMTC3 CCN1 TMEM9 FDFT1 UTP20 CHPF2 ZW10	1.39e-05	942	149	15	31073040
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	A2M ATRN TCTN3 COPB2 GEMIN5 NCSTN PTBP1 CDC45 LRIG2 IGF2BP3 FDFT1 CHPF2	1.43e-05	613	149	12	22268729
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	ATRN TCTN3 SEMA3C ADAM9 NCSTN DNAJB14 LRIG2 CSDE1 TMTC3 CCN1 TMEM9 GLG1 FDFT1 UTP20 CHPF2 BMPER DCBLD2	1.66e-05	1201	149	17	35696571
Pubmed	Internal initiation of translation from the human rhinovirus-2 internal ribosome entry site requires the binding of Unr to two distinct sites on the 5' untranslated region.	PTBP1 CSDE1	1.82e-05	2	149	2	17947529
Pubmed	The armadillo-repeat domain of Plakophilin 1 binds to human enzyme PADI4.	PADI4 PKP1	1.82e-05	2	149	2	36372391
Pubmed	Cryo-EM structure of ACE2-SIT1 in complex with tiagabine.	ACE2 SLC6A20	1.82e-05	2	149	2	39159813
Pubmed	Mitotic DNA Synthesis in Untransformed Human Cells Preserves Common Fragile Site Stability via a FANCD2-Driven Mechanism That Requires HELQ.	HELQ FANCD2	1.82e-05	2	149	2	37777152
Pubmed	Dickkopf‑1/cysteine‑rich angiogenic inducer 61 axis mediates palmitic acid‑induced inflammation and apoptosis of vascular endothelial cells.	DKK1 CCN1	1.82e-05	2	149	2	33300071
Pubmed	Localization and phenotype-specific expression of ryanodine calcium release channels in C57BL6 and DBA/2J mouse strains.	RYR1 GPNMB	1.82e-05	2	149	2	21933672
Pubmed	A disintegrin and metalloproteinase domain 9 facilitates SARS-CoV-2 entry into cells with low ACE2 expression.	ADAM9 ACE2	1.82e-05	2	149	2	37713503
Pubmed	The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr.	PTBP1 CSDE1	5.45e-05	3	149	2	12667457
Pubmed	Loss of angiotensin-converting enzyme 2 exacerbates myocardial injury via activation of the CTGF-fractalkine signaling pathway.	ACE2 CX3CL1	5.45e-05	3	149	2	24161906
Pubmed	Upregulation of the angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptor axis in the heart and the kidney of growth hormone receptor knock-out mice.	GHR ACE2	5.45e-05	3	149	2	22947377
Pubmed	Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes.	A2M ADAMTS5	5.45e-05	3	149	2	14715656
Pubmed	In vivo analysis of gene expression in long-lived mice lacking the pregnancy-associated plasma protein A (PappA) gene.	GHR PAPPA	5.45e-05	3	149	2	20197085
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	SHLD2 DOCK9 COPB2 ZNF254 ZNF267 NOL11 GEMIN5 NCSTN ZNF699 CUBN ESCO2 PSME4 PTPRR GLG1 MACF1	6.91e-05	1084	149	15	11544199
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DCAF1 NRCAM POGK ADAM9 DOCK9 CSDE1 MACF1 CHPF2 TET3	6.96e-05	407	149	9	12693553
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	DCAF1 POGK ZNF618 DBT GPR108 ZNF829 FANCD2 MALT1 ZBTB7A NAA35 ARHGEF40 MACF1 CHPF2 AGBL1 RAI1	9.54e-05	1116	149	15	31753913
Pubmed	Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.	SEMA3C ADAM9 ADAMTS5 GHR CCN1 PAPPA BMPER	1.02e-04	248	149	7	24006456
Pubmed	Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.	DLL4 NCSTN	1.09e-04	4	149	2	22547652
Pubmed	A PRC2-dependent repressive role of PRDM14 in human embryonic stem cells and induced pluripotent stem cell reprogramming.	EED PRDM14	1.09e-04	4	149	2	23280602
Pubmed	LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance.	DLL4 ZBTB7A	1.09e-04	4	149	2	23134786
Pubmed	A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry.	ACE2 TMPRSS11A	1.09e-04	4	149	2	21068237
Pubmed	EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3.	DBT PTBP1 PRKRA CSDE1 IGF2BP3 CCN1	1.09e-04	174	149	6	35031058
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	ADAM9 SPTBN2 MPRIP KCNJ4 MACF1 CTNND2 ANKS1A	1.10e-04	251	149	7	27507650
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	A2M SEMA3C POGK ADAM9 CDC45 CSDE1 ACE2 ARHGEF40 PSME4 AKAP13 CHPF2	1.20e-04	650	149	11	38777146
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	SPTBN2 COPB2 NOL11 GEMIN5 LCP1 PRKRA CSDE1 IGF2BP3 MACF1 UTP20 RAI1	1.25e-04	653	149	11	22586326
Pubmed	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.	DOCK9 MRPL37 COPB2 GEMIN5 NCSTN PTBP1 LCP1 IGF2BP3 ASAP2 FDFT1 AGL MACF1 ZW10 DCBLD2 TPI1	1.36e-04	1153	149	15	29845934
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	CORO1C COPB2 NOL11 ZNF880 CSDE1 IGF2BP3 ZNF716 ZNF852 ZW10	1.51e-04	451	149	9	36168627
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	EED GEMIN5 TEX11 GHR MACF1 AKAP13 CTNND2 TMPRSS11A	1.74e-04	361	149	8	26167880
Pubmed	Genome-wide association study of maternal and inherited loci for conotruncal heart defects.	KCNJ4 PAPPA	1.81e-04	5	149	2	24800985
Pubmed	CRL4(VprBP) E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases.	DCAF1 TET3	1.81e-04	5	149	2	25557551
Pubmed	Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links.	DCLRE1B FANCD2	1.81e-04	5	149	2	18469862
Pubmed	Human intestine luminal ACE2 and amino acid transporter expression increased by ACE-inhibitors.	ACE2 SLC6A20	1.81e-04	5	149	2	25534429
Pubmed	Polymorphic variation within the ADAMTS2, ADAMTS14, ADAMTS5, ADAM12 and TIMP2 genes and the risk of Achilles tendon pathology: a genetic association study.	ADAMTS5 ADAMTS14	1.81e-04	5	149	2	23491141
Pubmed	Chromosomal mapping of human armadillo genes belonging to the p120(ctn)/plakophilin subfamily.	PKP1 CTNND2	1.81e-04	5	149	2	9721216
Pubmed	Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice.	IGF2BP3 GPNMB	1.81e-04	5	149	2	11743578
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	NRCAM ADAM9 SPTBN2 ASAP2 PKP1 MACF1 CTNND2	2.20e-04	281	149	7	28706196
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DCAF1 EED MRPL37 SPTBN2 NOL11 DBT DNAJB14 MPRIP LRIG2 NAA35 TMTC3 GLG1 FDFT1 ARL13B MACF1 AKAP13 TPI1	2.26e-04	1487	149	17	33957083
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ATRN PTPN18 CSDE1 MALT1 ZBTB7A ASAP2 NFATC1 PTPRR PROM2 MACF1 AKAP13 ZNF528 ERMARD TET3 KDM4B RAI1 ANKS1A	2.29e-04	1489	149	17	28611215
Pubmed	ASTE1 promotes shieldin-complex-mediated DNA repair by attenuating end resection.	SHLD2 ASTE1	2.70e-04	6	149	2	34354233
Pubmed	Light-Controlled Affinity Purification of Protein Complexes Exemplified by the Resting ZAP70 Interactome.	TRBC2 TRBC1	2.70e-04	6	149	2	30863395
Pubmed	Sequence and evolution of the human T-cell antigen receptor beta-chain genes.	TRBC2 TRBC1	2.70e-04	6	149	2	3860845
Pubmed	PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase.	PSTPIP2 PTPN18	2.70e-04	6	149	2	9804817
Pubmed	The SARS-CoV-2 RNA interactome.	MRPL37 PTBP1 CSDE1 IGF2BP3	2.95e-04	74	149	4	33989516
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	COPB2 NOL11 GEMIN5 PTBP1 PRKRA CSDE1 IGF2BP3 AGL TPI1	2.95e-04	494	149	9	26831064
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	A2M DCAF1 COPB2 NCSTN PSTPIP2 LCP1 PTPN18 CDC45 FANCD2 LRIG2 TMTC3 PTPRR AGL	3.03e-04	974	149	13	28675297
Pubmed	SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.	A2M CORO1C COPB2 GEMIN5 LCP1 CSDE1 IGF2BP3 FDFT1 AGL TPI1	3.04e-04	607	149	10	39147351
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADAMTS5 CUBN CCN1 ADAMTS14	3.10e-04	75	149	4	20637190
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	TCTN3 TMED6 CILP DLL4 DNAJB14 CDC45 ACE2 DKK1 TMEM9 PROM2 CHPF2 FCRL5 GPNMB	3.37e-04	985	149	13	12975309
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	COPB2 LCP1 ZFYVE9 FDFT1 PRR14L	3.42e-04	139	149	5	25476789
Pubmed	Gene expression profiles in normal and Otx2-/- early gastrulating mouse embryos.	EED DKK1	3.78e-04	7	149	2	11114168
Pubmed	Regulatory mechanisms in T cell receptor signalling.	TRBC2 TRBC1	3.78e-04	7	149	2	29789755
Pubmed	Endothelial deletion of PTBP1 disrupts ventricular chamber development.	PTBP1 NFATC1	3.78e-04	7	149	2	37002228
Pubmed	SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.	SHLD2 CDC45 FANCD2 IGF2BP3 RAI1	4.85e-04	150	149	5	30154076
Pubmed	High-resolution linkage map in the proximity of the host resistance locus Cmv1.	A2M TPI1	5.02e-04	8	149	2	9027502
Pubmed	DNA polymerase POLN participates in cross-link repair and homologous recombination.	HELQ FANCD2	5.02e-04	8	149	2	19995904
Pubmed	EED is required for mouse primordial germ cell differentiation in the embryonic gonad.	EED PIWIL2	5.02e-04	8	149	2	35679863
Pubmed	MicroRNA-124 suppresses the transactivation of nuclear factor of activated T cells by targeting multiple genes and inhibits the proliferation of pulmonary artery smooth muscle cells.	PTBP1 NFATC1	5.02e-04	8	149	2	23853098
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	SEMA3C CORO1C COPB2 GEMIN5 NCSTN PTBP1 FANCD2 TMTC3 FDFT1 ZW10	5.64e-04	657	149	10	36180527
Pubmed	Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation.	DLL4 ADAMTS5 NFATC1	5.82e-04	38	149	3	29743679
Pubmed	Two major interacting chromosome loci control disease susceptibility in murine model of spondyloarthropathy.	PSTPIP2 NFATC1	6.44e-04	9	149	2	16081819
Pubmed	Fanconi anemia proteins interact with CtBP1 and modulate the expression of the Wnt antagonist Dickkopf-1.	FANCD2 DKK1	6.44e-04	9	149	2	23303816
Pubmed	LDL-receptor-related protein 6 is a receptor for Dickkopf proteins.	SPTBN2 DKK1	6.44e-04	9	149	2	11357136
Pubmed	Comparative analysis of KRAB zinc finger proteins in rodents and man: evidence for several evolutionarily distinct subfamilies of KRAB zinc finger genes.	ZNF254 ZNF699	6.44e-04	9	149	2	10360839
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	TCTN3 NCSTN LRIG2 TMTC3 CHPF2	7.26e-04	164	149	5	32409323
Pubmed	Accelerated coronary angiogenesis by vegfr1-knockout endocardial cells.	DLL4 NFATC1	8.02e-04	10	149	2	23894673
Pubmed	mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO mice.	GHR PAPPA	8.02e-04	10	149	2	27618784
Pubmed	Dysregulation of the TET family of epigenetic regulators in lymphoid and myeloid malignancies.	NCSTN TET3	8.02e-04	10	149	2	31467060
Pubmed	Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.	EED PRDM14 KDM4B	8.97e-04	44	149	3	24183668
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	NRCAM ZNF618 ADAM9 CORO1C SPTBN2 MPRIP LRIG2 KCNJ4 MACF1 CTNND2 RAI1 ANKS1A	9.41e-04	963	149	12	28671696
Pubmed	Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors.	NCSTN HELQ MPRIP PRKRA ESCO2 FANCD2 PROM2	9.44e-04	359	149	7	35559673
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	POGK CORO1C MRPL37 COPB2 NOL11 PRKRA FANCD2 IGF2BP3 AGL UTP20	9.53e-04	704	149	10	29955894
Pubmed	Delta-like ligand 4-mediated Notch signaling controls proliferation of second heart field progenitor cells by regulating Fgf8 expression.	SEMA3C DLL4	9.78e-04	11	149	2	32778568
Pubmed	Rab11a Is Essential for the Development and Integrity of the Stereocilia and Kinocilia in the Mammalian Organ of Corti.	SPTBN2 ARL13B	9.78e-04	11	149	2	37225424
Pubmed	APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer.	CDC45 FANCD2	9.78e-04	11	149	2	22293751
Pubmed	An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.	A2M NCSTN	9.78e-04	11	149	2	19105203
Pubmed	Variants in LRRC7 lead to intellectual disability, autism, aggression and abnormal eating behaviors.	MACF1 CTNND2	9.78e-04	11	149	2	39256359
Pubmed	Notch-Tnf signalling is required for development and homeostasis of arterial valves.	DLL4 NFATC1	9.78e-04	11	149	2	26491108
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	A2M SEMA3C CORO1C SPTBN2 NOL11 DBT PTBP1 MPRIP PRKRA CSDE1 CCN1 PKP1 UTP20 TPI1	1.06e-03	1257	149	14	36526897
Pubmed	Dosage-dependent transcriptional regulation by the calcineurin/NFAT signaling in developing myocardium transition.	LCP1 ACE2 NFATC1	1.09e-03	47	149	3	17198697
Pubmed	CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.	COPB2 PTBP1 MPRIP CSDE1 GLG1	1.16e-03	182	149	5	31067453
Pubmed	Proteomic-based detection of a protein cluster dysregulated during cardiovascular development identifies biomarkers of congenital heart defects.	PCSK1 TRPC5	1.17e-03	12	149	2	19156209
Pubmed	HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis.	HELQ FANCD2	1.17e-03	12	149	2	24005329
Pubmed	Spatial gene expression in the T-stage mouse metanephros.	SIM1 BMPER	1.17e-03	12	149	2	16545622
Pubmed	Accelerated failure time models provide a useful statistical framework for aging research.	GHR PAPPA	1.17e-03	12	149	2	19007875
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	COPB2 NOL11 GEMIN5 PSTPIP2 MPRIP PRKRA CSDE1 IGF2BP3 MACF1 AKAP13	1.18e-03	724	149	10	36232890
Pubmed	The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation.	ADAM9 CORO1C SPTBN2 NOL11 NCSTN PTBP1 RYR1 MPRIP ARL13B	1.23e-03	604	149	9	37616343
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	A2M SEMA3C SPTBN2 ZNF267 NOL11 LCP1 RYR1 PRKRA ARHGEF40 TPI1	1.28e-03	732	149	10	34732716
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	NRCAM CORO1C DOCK9 COPB2 DBT PTBP1 PRKRA CSDE1 GLG1 PKP1 MACF1 CTNND2 TPI1	1.28e-03	1139	149	13	36417873
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ATRN NRCAM ADAM9 CORO1C SPTBN2 MPRIP PRKRA CSDE1 CCN1 ZNF197 ARL13B MACF1 ZNF528 CTNND2	1.30e-03	1285	149	14	35914814
Pubmed	ANXA1-derived peptide for targeting PD-L1 degradation inhibits tumor immune evasion in multiple cancers.	CORO1C IGF2BP3 CCN1	1.30e-03	50	149	3	37001908
Pubmed	A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure.	DKK1 TET3	1.38e-03	13	149	2	26989192
Pubmed	Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial VEGF signaling.	DLL4 NFATC1	1.38e-03	13	149	2	23178125
Cytoband	Ensembl 112 genes in cytogenetic band chr3p21	DCAF1 MON1A ZDHHC3 ZNF852 ZNF197 SLC6A20 PRSS50	8.34e-05	316	149	7	chr3p21
Cytoband	3p21.31	MON1A ZDHHC3 ZNF852 PRSS50	3.28e-04	100	149	4	3p21.31
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF157 ZNF618 ZNF254 ZNF267 ZNF880 ZNF215 ZNF699 ZNF829 ZNF587B ZNF77 ZNF17 ZBTB7A ZNF716 ZNF852 ZNF732 ZNF728 ZNF197 ZNF814 ZNF534 ZNF528 PRDM14 ZNF304	2.56e-10	718	109	22	28
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PADI4 CUBN RYR1 IGF2BP3 CTNND2 AGBL1 SLC30A10	1.54e-06	167	149	7	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SEMA3C CDC45 ESCO2 FANCD2 ZNF732 ADAMTS14 RPE65	4.02e-06	193	149	7	516ea2c12bdc7a5dc676159d627e36f6abe13ef0
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PCSK1 SEMA3C NRCAM ADAM9 DKK1 CCN1 DCBLD2	4.16e-06	194	149	7	f44394c8a6f86483063f2f5722f003a8a0a70254
ToppCell	droplet-Fat-SCAT-30m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CMKLR2 SEMA3C CILP ADAMTS5 GHR CCN1 GPNMB	4.16e-06	194	149	7	0e315c63407fa00643722a7d6138b1502f79b10d
ToppCell	droplet-Fat-SCAT-30m-Mesenchymal-Cd34+\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CMKLR2 SEMA3C CILP ADAMTS5 GHR CCN1 GPNMB	4.16e-06	194	149	7	588c45dafa00547b2506e298a2434b1b5e15560d
ToppCell	droplet-Fat-SCAT-30m-Mesenchymal\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CMKLR2 SEMA3C CILP ADAMTS5 GHR CCN1 GPNMB	4.16e-06	194	149	7	c2990d6eda3954dc01913bf3910df79f06e0010a
ToppCell	Control-Endothelial-Epi-like\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PADI4 NRCAM ASTE1 LGSN FANCD2 ARHGEF40	1.49e-05	157	149	6	4d02c50d5d1b892ea241e98724386d8a5a156a46
ToppCell	Control-Endothelial-Epi-like-Alv_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PADI4 NRCAM ASTE1 LGSN FANCD2 ARHGEF40	1.49e-05	157	149	6	2c369660c752c0fb3bd798a561d3359e2f9aa983
ToppCell	367C-Fibroblasts-Fibroblast-F\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	SEMA3C ADAMTS5 TEX11 ESCO2 ZNF728 TMPRSS11A	1.72e-05	161	149	6	c61283c301a87bb802f6f8ce79c26067032dd7d9
ToppCell	367C-Fibroblasts-Fibroblast-F-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	SEMA3C ADAMTS5 TEX11 ESCO2 ZNF728 TMPRSS11A	1.72e-05	161	149	6	9864d8b0929dacf4be7a4e97d2527ac3120ea264
ToppCell	343B-Fibroblasts-Fibroblast-D-\|343B / Donor, Lineage, Cell class and subclass (all cells)	CILP ADAMTS5 TEX11 ZNF77 ESCO2 ASAP2	1.85e-05	163	149	6	8d2b2119c6b3d5b677da6f377fd85146590e1246
ToppCell	E18.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ASPHD2 SIM1 PTPN18 CDC45 TRBC2 TRBC1	1.85e-05	163	149	6	9c91415a56b12b3b2d15d253bb59db8bedf49ea2
ToppCell	343B-Fibroblasts-Fibroblast-D\|343B / Donor, Lineage, Cell class and subclass (all cells)	CILP ADAMTS5 TEX11 ZNF77 ESCO2 ASAP2	1.85e-05	163	149	6	acfb2ece6202479e615d54fd3ecb8b4a571b5a18
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	A2M SEMA3C NRCAM ADAMTS5 BMPER PRDM14	1.91e-05	164	149	6	e3983f655cdba308fb192182829f17bef99ce0ba
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3C NRCAM SPTBN2 ADAMTS5 ZDHHC3 FBN3	1.98e-05	165	149	6	a6c6de17fec678ad0cac3138dde3a14cc39ffd26
ToppCell	367C-Fibroblasts-Fibroblast-F\|367C / Donor, Lineage, Cell class and subclass (all cells)	CMKLR2 SEMA3C ADAMTS5 TEX11 ZNF728 TMPRSS11A	2.05e-05	166	149	6	2887f4f0c218cbcbcc82eef27aa4ee714b35cddb
ToppCell	367C-Fibroblasts-Fibroblast-F-\|367C / Donor, Lineage, Cell class and subclass (all cells)	CMKLR2 SEMA3C ADAMTS5 TEX11 ZNF728 TMPRSS11A	2.05e-05	166	149	6	1cc291a04f4144abba4aca7badeb7776db05d903
ToppCell	3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPTBN2 ZNF254 DKK1 CCN1 PKP1 RAI1	2.42e-05	171	149	6	ea60d9e9df28ab991fbdb596784b44f6a9fc5827
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_G2M\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ANKLE1 CMC2 CDC45 ESCO2 FDFT1 TRBC2	2.50e-05	172	149	6	1171e754fd503a0c1152162fcc12a115088a08c7
ToppCell	normal_Lung-Endothelial_cells-EPCs\|normal_Lung / Location, Cell class and cell subclass	A2M DLL4 DOCK9 ASAP2 PTPRR CX3CL1	2.84e-05	176	149	6	71d1bd425772d89d8c550b909e0ec0e36ff22a7e
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCTN3 PADI4 ACE2 SLC6A20 GPNMB DCBLD2	3.13e-05	179	149	6	e880c507f11ce75d104593a4ca29f0295f8125e8
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAM7 SPTBN2 CHST1 ST8SIA3 RYR1 KCNJ4	3.13e-05	179	149	6	a3922476f33d2e4137a12dbda21a1703dff79684
ToppCell	droplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GLS2 DLL4 DOCK9 ADAMTS5 GHR PTPRR	3.65e-05	184	149	6	f506d0ee48f39d6f59f19554217dfdf0987cc405
ToppCell	droplet-Lung-30m-Endothelial-arterial_endothelial\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GLS2 DLL4 DOCK9 ADAMTS5 GHR PTPRR	3.65e-05	184	149	6	8bcb1c4bc8ffef74338cdade926a94711de93c64
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DLL4 DOCK9 ASAP2 TIFA CTNND2 CX3CL1	3.76e-05	185	149	6	808d5e880069aff8866cd2c733b9fe568a37701f
ToppCell	356C-Endothelial_cells-Endothelial-E-\|356C / Donor, Lineage, Cell class and subclass (all cells)	A2M ZCWPW2 DLL4 DOCK9 CUBN PKP1	3.87e-05	186	149	6	2e024097ee361eeb1d855a4edb8ac8cdad35da06
ToppCell	356C-Endothelial_cells-Endothelial-E\|356C / Donor, Lineage, Cell class and subclass (all cells)	A2M ZCWPW2 DLL4 DOCK9 CUBN PKP1	3.87e-05	186	149	6	c3449e54454009973818fc1101933c6f0168258c
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RYR1 CDC45 ESCO2 AGL PKP1 TMPRSS11A	4.49e-05	191	149	6	0f9443da0f73d07456142fae08b2dc92a5b7b592
ToppCell	5'-Adult-LymphNode-Mesenchymal\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CILP ZFAND5 CCN1 PRSS50 PAPPA GPNMB	4.49e-05	191	149	6	054e9a79bd1486fd812bc7418fb091664fe3a646
ToppCell	facs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CMKLR2 SEMA3C ASPHD2 CHST1 ADAMTS5 DCBLD2	4.62e-05	192	149	6	30cefa0990ba1f379f350bfbf994a78db145075e
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	A2M SEMA3C NRCAM ADAMTS5 GHR SLC30A10	4.62e-05	192	149	6	72881b280a415e65f87a80ca1369cbb0b722a0c4
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3C ADAM9 CORO1C NFATC1 MACF1 AKAP13	4.62e-05	192	149	6	8b86db2ebe0199fee0e9800566a619a24bfdeed5
ToppCell	10x3'2.3-week_17-19-Mesenchymal_fibro-stroma-endosteal_fibroblast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CMKLR2 SEMA3C CILP MUC12 PKP1 GPNMB	4.90e-05	194	149	6	69362e13158033de44f90f3773db6c0f27de8cb3
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	A2M ADAM9 HLA-DRB5 ZFAND5 AKAP13 GPNMB	4.90e-05	194	149	6	449ce4167d64c170d914e0250f739eabedcf915d
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CMKLR2 SEMA3C ASPHD2 CHST1 ADAMTS5 DCBLD2	5.18e-05	196	149	6	ed6047b48b6a96baa6a90c7af784e7c34b32824d
ToppCell	5'-Adult-LargeIntestine-Epithelial-Tuft-related\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DLL4 MUC12 PSTPIP2 PTPN18 PTPRR ADAMTS14	5.48e-05	198	149	6	a631be84e29c277216d89ec6265bd43e87c1dc86
ToppCell	Tracheal-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	A2M DLL4 DOCK9 HLA-DRB5 PTPRR CTNND2	5.64e-05	199	149	6	9735a1dc10910f02f1106b20ae5ab4c09c21305e
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RYR1 TMTC3 PROM2 AGL TMPRSS11A TPI1	5.64e-05	199	149	6	ba284f984909504221900bca5ea12ada5b2ffd9f
ToppCell	Sigmoid-(6)_Macrophage-(61)_LYVE1_Macrophage\|Sigmoid / shred on region, Cell_type, and subtype	A2M ADAM9 HLA-DRB5 PSTPIP2 ASAP2 GPNMB	5.80e-05	200	149	6	bc0280d52e4edc2c5edf4ead164a1c7cf3fccd60
ToppCell	Sigmoid-Macrophage-LYVE1_Macrophage\|Sigmoid / Region, Cell class and subclass	A2M ADAM9 HLA-DRB5 PSTPIP2 ASAP2 GPNMB	5.80e-05	200	149	6	851a1b372ddbec522829069e69ed36a1f4832131
Disease	osteoarthritis (is_implicated_in)	CILP ADAMTS5 GHR ADAMTS14	1.04e-05	28	145	4	DOID:8398 (is_implicated_in)
Disease	rheumatoid arthritis (is_marker_for)	SEMA3C ADAMTS5 ESCO2 CCN1 CX3CL1	2.33e-05	69	145	5	DOID:7148 (is_marker_for)
Disease	Juvenile osteoporosis	COPB2 DKK1	1.43e-04	4	145	2	C0264080
Disease	Lissencephaly	TMTC3 MACF1	3.55e-04	6	145	2	C0266463
Disease	platelet component distribution width	EED DLL4 POGK DOCK9 CUBN PTBP1 TEX11 LCP1 MPRIP MACF1 AKAP13 ANKS1A	3.67e-04	755	145	12	EFO_0007984
Disease	Periventricular Nodular Heterotopia	TMTC3 ERMARD	4.96e-04	7	145	2	C1868720
Disease	macrophage inflammatory protein 1b measurement	DCAF1 MON1A ZDHHC3 ZNF852 ZNF197	5.74e-04	136	145	5	EFO_0008219
Disease	systemic lupus erythematosus	GLS2 HLA-DRB5 LCP1 GHR LRIG2 NFATC1 FDFT1 FCRL5 CX3CL1 TET3 KDM4B ANKS1A	6.06e-04	799	145	12	MONDO_0007915
Disease	Abnormality of the face	FDFT1 TET3	8.44e-04	9	145	2	C4025871
Disease	Liver carcinoma	A2M CDC45 FANCD2 GHR IGF2BP3 CCN1 FDFT1 PKP1 BMPER	9.38e-04	507	145	9	C2239176
Disease	autism spectrum disorder (implicated_via_orthology)	NRCAM TRPC5 CSDE1 PKP1 CTNND2	9.48e-04	152	145	5	DOID:0060041 (implicated_via_orthology)
Disease	pars orbitalis volume measurement	FCRL5 ACSS3	1.28e-03	11	145	2	EFO_0010320
Disease	GM3 ganglioside measurement	CTNND2 FBN3	1.28e-03	11	145	2	EFO_0021451
Disease	Acute Confusional Senile Dementia	A2M HLA-DRB5 NCSTN TPI1	1.47e-03	99	145	4	C0546126
Disease	Alzheimer's Disease, Focal Onset	A2M HLA-DRB5 NCSTN TPI1	1.47e-03	99	145	4	C0750900
Disease	Alzheimer Disease, Early Onset	A2M HLA-DRB5 NCSTN TPI1	1.47e-03	99	145	4	C0750901
Disease	Presenile dementia	A2M HLA-DRB5 NCSTN TPI1	1.47e-03	99	145	4	C0011265
Disease	Alzheimer Disease, Late Onset	A2M HLA-DRB5 NCSTN TPI1	1.47e-03	99	145	4	C0494463
Disease	Familial Alzheimer Disease (FAD)	A2M HLA-DRB5 NCSTN TPI1	1.52e-03	100	145	4	C0276496
Disease	Alzheimer's Disease	A2M HLA-DRB5 NCSTN TPI1	1.58e-03	101	145	4	C0002395
Disease	Intellectual Disability	PRKRA CSDE1 ACE2 FDFT1 ARL13B MACF1 TET3 RAI1	1.71e-03	447	145	8	C3714756
Disease	filaggrin gene expression measurement	ZNF618 ZNF254	2.75e-03	16	145	2	EFO_0020899
Disease	lean body mass	PCSK1 GPR139 GHR IGF2BP3 ARHGEF40 PAPPA AKAP13	2.77e-03	379	145	7	EFO_0004995
Disease	Dystonia, Limb	PRKRA SLC30A10	3.11e-03	17	145	2	C0751093
Disease	Dystonia, Diurnal	PRKRA SLC30A10	3.11e-03	17	145	2	C0393610
Disease	Dystonia, Paroxysmal	PRKRA SLC30A10	3.48e-03	18	145	2	C0393588
Disease	bitter alcoholic beverage consumption measurement	ST8SIA3 AGBL1 TET3 ACSS3	4.27e-03	133	145	4	EFO_0010092
Disease	Familial aplasia of the vermis	TCTN3 ARL13B	4.30e-03	20	145	2	cv:C0431399
Disease	body surface area	PCSK1 SIM1 GPR139 GHR IGF2BP3 ARHGEF40 MACF1 PAPPA AKAP13	4.63e-03	643	145	9	EFO_0022196
Disease	COVID-19 (is_implicated_in)	A2M ACE2	4.74e-03	21	145	2	DOID:0080600 (is_implicated_in)
Disease	osteoarthritis (biomarker_via_orthology)	ADAMTS5 NFATC1	4.74e-03	21	145	2	DOID:8398 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LQNASPHYQNIKENC	PTPN18	296	Q99952
KVQQEACAQYSGFLF	ARHGEF40	61	Q8TER5
QTLTNQKQGHCYGVV	ANKLE1	561	Q8NAG6
PALKFSKCSQNQYHQ	ADAM7	366	Q9H2U9
KSFRHEQCEAKNGYQ	ADAMTS5	626	Q9UNA0
YQNKTCVQTLEGHAQ	COPB2	216	P35606
IYQNGESFQPNCKHQ	CCN1	106	O00622
DENCQINRYGHFQAT	GPNMB	366	Q14956
TYGKFCGQHNQSVNY	AKAP13	2096	Q12802
CGQHNQSVNYFKDLY	AKAP13	2101	Q12802
RHVFGQAVKNDQCYD	CORO1C	11	Q9ULV4
DKSNCGKQQNHTLDY	DLL4	601	Q9NR61
QARLFFHCSQYNGNL	CSDE1	46	O75534
FHCSQYNGNLQDLKV	CSDE1	51	O75534
HNGQKNNEFGLVENY	ARL13B	306	Q3SXY8
NNDNETALHCAAQYG	ANKS1A	146	Q92625
HYNGTCQNELAFNVT	FBN3	1656	Q75N90
GKQIHTLYLDNTNCN	DCLRE1B	136	Q9H816
VQSNAAAYLQHLCFG	CTNND2	566	Q9UQB3
QSQVKLQDFFQCGTY	ASTE1	301	Q2TB18
QQCAKRNSYYVHQNA	ADAMTS14	616	Q8WXS8
SGQLNSHGCFYQQVK	A2M	291	P01023
YHFNIINCEKPNSQF	AGBL1	646	Q96MI9
ERCGFHGKQQNYQQT	RAI1	6	Q7Z5J4
YDNIIQHLNNGRKNC	PSTPIP2	21	Q9H939
VHDQDSGKNGQVVCY	PCDHGA8	371	Q9Y5G5
VIKQCYQDHNLSQNG	NCSTN	191	Q92542
FVKKNGQCNVYFANL	KCNJ4	21	P48050
CNFQTGEYVVVHDNK	NOL11	71	Q9H8H0
ENCQNITYKASHNIG	DBT	331	P11182
SCYKLFQEQQNEGHG	PADI4	496	Q9UM07
NVFSGQEEASYNCHN	DCAF1	1121	Q9Y4B6
QYSQKCLENAHLAQA	MPRIP	826	Q6WCQ1
FLQQDKYECHFFNGT	HLA-DRB5	36	Q30154
HVKDAGFYVCRVNNN	MALT1	181	Q9UDY8
GNYQCIAKNALGAIH	NRCAM	336	Q92823
KEYNTNTCDQNLNHC	SPATA18	26	Q8TC71
IKYFHAQCNFFQDGL	ASAP2	221	O43150
KENYDNAKLFCRNHN	ATRN	806	O75882
AACYNNQQVFKGAVK	FDFT1	301	P37268
YHLENAGCNKIGNFS	LCP1	276	P13796
NYSCEANNGLVAQHS	FCRL5	631	Q96RD9
EITSCLGLYHNNNQF	NFATC1	121	O95644
GKAAFNQEHVSCQQA	KDM4B	536	O94953
QCIKHYVGHGNAINE	EED	181	O75530
CQKLVSLFNFHNYDN	GLS2	451	Q9UI32
LDQNYICGYSHQNSQ	MS4A5	141	Q9H3V2
YAESTNNCQAAKQFG	POGK	211	Q9P215
QTQHLAVFYKGCISQ	OR1J1	86	Q8NGS3
KFHGLYQCTNGFQFN	PAPPA	1421	Q13219
HECNIYDVKNDTGFQ	MRPL37	266	Q9BZE1
FHCQYGVLGELNQSQ	HIDE1	86	A8MVS5
GHFYACQVAQRKIQE	IGF2BP3	541	O00425
KAYHDLCDGSANQLQ	MACF1	1516	Q9UPN3
CFSGNNDHFLAINQK	PTPRR	21	Q15256
GAQLSHIFQQKQNYD	MON1A	346	Q86VX9
QIADCNRDYHKAFGN	CUBN	3391	O60494
KNFCSAVQYGNAQII	GLG1	831	Q92896
CTHNEGLNQKLYHNL	ASPHD2	116	Q6ICH7
KEQFHYFILINCGAN	CDC45	66	O75419
QQNCAATQCKHGAVY	BMPER	621	Q8N8U9
QHLHNFFQYCQKTES	DOCK9	826	Q9BZ29
LDQKNQNNSPYHDAC	GHR	426	P10912
KQYDLTGNEEQACNH	DNAJB14	166	Q8TBM8
KNHNILKFFGYCNDV	CMC2	26	Q9NRP2
YQFQFQEALCQAAKH	ACE2	521	Q9BYF1
DVFIQNGYPCQNNKA	ADAM9	496	Q13443
FYQNSDKNEENLHCS	ESCO2	36	Q56NI9
YKGHRNNDTIKCVNF	DCAF8L1	431	A6NGE4
NIHAVCGKNAHEYQQ	ERMARD	601	Q5T6L9
FQGNKDYHQDVRNNF	DCBLD2	406	Q96PD2
NCYSHLVQEFTKGIQ	HELQ	741	Q8TDG4
CQKQPVQFYTNHNFS	GPR139	306	Q6DWJ6
NYCKNGICVSSDQNH	DKK1	131	O94907
QKASHDQEYLCNIGD	RSC1A1	181	Q92681
CEGHNNDFQNYLRTQ	RYR1	3891	P21817
HNYFQCLAAENHGVV	FANCD2	1031	Q9BXW9
YNDNSCIFNIKCHGE	LGSN	386	Q5TDP6
FCKYNISDHAIQELN	PRR14L	916	Q5THK1
HVQVCNKAPAQHQYS	MROH2A	351	A6NES4
HTCFQDESAKQQVYQ	PKP1	271	Q13835
VIDKCQSFNQLVYHQ	UTP20	71	O75691
NIGNCFGKNFSIAYN	RPE65	191	Q16518
NQYCKDTRQQHQQGD	SEMA3C	706	Q99985
EQNLVAVQCQGHIFY	PRDM14	336	Q9GZV8
GHIFYESCKEIHQNQ	PRDM14	346	Q9GZV8
RNSNICHYTFQDKQV	TIFA	51	Q96CG3
AIYQQNKEHFQDECT	PIWIL2	396	Q8TC59
EEGQYSLNFHNCNNS	GPR108	216	Q9NPR9
NGAGKKHSLCFANYQ	SIM1	596	P81133
KNFNTNLFQLGHKCA	SHLD2	161	Q86V20
NKHYNICAVVGNSGI	ST8SIA3	156	O43173
AFASYNEPSNNCQKH	SLC6A20	261	Q9NP91
NICYNAVDRHIENGK	ACSS3	111	Q9H6R3
FNNHTLCYNNFQKHD	CMKLR2	181	P46091
LQQHQAGEYFCKAQS	CILP	366	O75339
FAQNACQQVLAQLGY	CHST1	371	O43916
CVSQHQGQQYRSFEL	CHPF2	271	Q9P2E5
HGQSLNKTQEDQCYV	SLC30A10	466	Q6XR72
GHIYNQNVSQKDCNC	TMEM9	41	Q9P0T7
NNQVIHTADNPYKCN	ZNF880	201	Q6PDB4
CNQCGKAFSHAQYFQ	ZNF77	466	Q15935
QYSLLGQAKQAAHEC	nan	111	Q6ZTK2
CGKGFTYNRNLIEHQ	ZNF197	851	O14709
DQNVEYNGCRKAFHE	ZNF157	131	P51786
ACGIQFQFYNNLLEH	ZNF618	396	Q5T7W0
SVCYKEHLQRQQNSG	ZFAND5	31	O76080
NNCVGENNQKYFVLF	ZDHHC3	161	Q9NYG2
LYNNHQAKDCIDSFV	NAA35	411	Q5VZE5
ESLKKCNAHYNLQNA	SPTBN2	226	O15020
CNAHYNLQNAFNLAE	SPTBN2	231	O15020
GLRKNISIHQAYQQC	PROM2	536	Q8N271
ISIHQAYQQCKEGAA	PROM2	541	Q8N271
NHFRCQVQFYGLSEN	TRBC1	91	P01850
YRNVFIGEKNYHCNN	ZNF267	206	Q14586
QLCFQDQYVKAASHL	GEMIN5	971	Q8TEQ6
QSKVFQCGKYANIFH	ZNF728	141	P0DKX0
QETGFYQLCLSNQHN	TMED6	111	Q8WW62
EVHKGGYNYVNQCLS	ZNF716	136	A6NP11
AVAAQNCYKVTNGAF	TPI1	61	P60174
KYNECGKVFNQNSHL	ZNF534	256	Q76KX8
LHHLCYNFGVETQKN	TEX11	221	Q8IYF3
AHKDQHNLYNGCTVV	TET3	1076	O43151
QQQFKGALYCLLGNH	PSME4	1021	Q14997
GKAFKYCSNLNDHQR	ZNF829	246	Q3KNS6
CGNAQSDAAHNALQY	PRKRA	291	O75569
GNKLYDSGNFHQHQN	ZNF587B	126	E7ETH6
CGKSFNQNSYLIIHQ	ZNF852	416	Q6ZMS4
HFGNNFYQCVNCGKS	ZNF215	456	Q9UL58
LTNQVIHNADNPYKC	ZNF528	201	Q3MIS6
NKVHVGGCDQTFQAY	TXNRD3	126	Q86VQ6
VIAFSSYNKQDNNCH	SLC6A17	316	Q9H1V8
SYNKQDNNCHFDAAL	SLC6A17	321	Q9H1V8
NHFRCQVQFYGLSEN	TRBC2	91	A0A5B9
GNYALAQHCFIKSIQ	TTC37	841	Q6PGP7
YHQKEFVAQPNCQQL	TRPC5	296	Q9UL62
NFYQHQKQHNGENCF	ZNF304	131	Q9HCX3
GQLNEIYNLKHNLAC	TEX28	261	O15482
ESQLHQCGFKIVYSQ	ZCWPW2	81	Q504Y3
LHENQESCGIDYQNK	ZNF699	136	Q32M78
VQKGGYNEFNQCLST	ZNF732	121	B4DXR9
NVQGKHNLCVVYFEE	TMTC3	771	Q6ZXV5
CVHVNNSNLNYFQKL	TCTN3	161	Q6NUS6
IILNNKECDNFYHNF	PRSS50	266	Q9UI38
HAKLSLDGQNIYNAC	PTBP1	236	P26599
ALQKTLQCCGQHNYT	TSPAN19	146	P0C672
CGKAFSLKYNVVQHQ	ZNF17	251	P17021
KEGYNGLNQCFTTAQ	ZNF254	136	O75437
SHLVCVQNDDGNYQT	ZFYVE9	1171	O95405
QQCGAAFAHNYDLKN	ZBTB7A	441	O95365
GNKLYDSGNFHQHQN	ZNF814	126	B7Z6K7
QASLQYDNIHQCGAT	TMPRSS11A	201	Q6ZMR5
ALLIHYQQNQASCGK	CX3CL1	46	P78423
YARNINSHFANKKCQ	ZW10	391	O43264
YHQEQAVNCLLGNVF	AGL	391	P35573
QEQCTQKAAEGYTQF	MUC12	5301	Q9UKN1
HLFNVNFTDEGKYQC	LRIG2	566	O94898
NNHKCGVGVAYNSKV	PCSK1	221	P29120