Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	CHD8 CHD6 CHD7	1.36e-04	37	54	3	GO:0140658
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	PLEKHG4B TBC1D15 SGSM1 RAPGEF4 DEPDC1 SRGAP2 PLCG1	4.12e-04	507	54	7	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	PLEKHG4B TBC1D15 SGSM1 RAPGEF4 DEPDC1 SRGAP2 PLCG1	4.12e-04	507	54	7	GO:0030695
GeneOntologyBiologicalProcess	extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration	SRGAP2C SRGAP2	6.48e-06	2	53	2	GO:0021816
GeneOntologyBiologicalProcess	filopodium assembly	SRGAP2C PPP1R9A PRKCQ SRGAP2	4.81e-05	78	53	4	GO:0046847
GeneOntologyBiologicalProcess	modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration	SRGAP2C SRGAP2	6.45e-05	5	53	2	GO:0021815
GeneOntologyBiologicalProcess	cell motility involved in cerebral cortex radial glia guided migration	SRGAP2C SRGAP2	1.35e-04	7	53	2	GO:0021814
GeneOntologyBiologicalProcess	regulation of spontaneous synaptic transmission	PPP1R9A APP	1.35e-04	7	53	2	GO:0150003
GeneOntologyCellularComponent	growth cone lamellipodium	PPP1R9A APP	1.96e-05	3	54	2	GO:1990761
GeneOntologyCellularComponent	cone cell pedicle	SLC32A1 RAPGEF4	6.52e-05	5	54	2	GO:0044316
HumanPheno	Abnormal tracheal morphology	KMT2C FBN2 FANCL CHD6 CHD7 SCAF4 ZIC3	1.46e-06	170	19	7	HP:0002778
HumanPheno	Hypoplastic aortic arch	CREBBP SCAF4 ZIC3	1.56e-05	14	19	3	HP:0012304
HumanPheno	Tracheoesophageal fistula	FBN2 FANCL CHD7 SCAF4 ZIC3	1.92e-05	95	19	5	HP:0002575
HumanPheno	Abnormal earlobe morphology	SLC32A1 KMT2C OTUD5 CHD7 CREBBP	1.12e-04	137	19	5	HP:0000363
HumanPheno	Absent radius	FANCL CHD7 ZIC3	1.22e-04	27	19	3	HP:0003974
HumanPheno	Absent forearm bone	FANCL CHD7 ZIC3	1.36e-04	28	19	3	HP:0003953
HumanPheno	Aplasia involving forearm bones	FANCL CHD7 ZIC3	1.36e-04	28	19	3	HP:0009822
HumanPheno	Anal atresia	KMT2C FANCL CHD7 SCAF4 ZIC3	1.38e-04	143	19	5	HP:0002023
HumanPheno	Esophageal atresia	FANCL CHD7 ZIC3	2.45e-04	34	19	3	HP:0002032
HumanPheno	Abnormal duodenum morphology	FBN2 FANCL CHD7 ZIC3	2.64e-04	88	19	4	HP:0002246
HumanPheno	Gastrointestinal atresia	FBN2 FANCL CHD7 ZIC3	3.27e-04	93	19	4	HP:0002589
HumanPheno	Natal tooth	KMT2C CHD6 CREBBP	3.42e-04	38	19	3	HP:0000695
Domain	BRK	CHD8 CHD6 CHD7	4.54e-07	6	54	3	SM00592
Domain	BRK_domain	CHD8 CHD6 CHD7	4.54e-07	6	54	3	IPR006576
Domain	BRK	CHD8 CHD6 CHD7	4.54e-07	6	54	3	PF07533
Domain	srGAP2	SRGAP2C SRGAP2	2.46e-05	3	54	2	IPR030252
Domain	Chromo_domain	CHD8 CHD6 CHD7	4.43e-05	24	54	3	IPR023780
Domain	Chromo	CHD8 CHD6 CHD7	5.67e-05	26	54	3	PF00385
Domain	CHROMO_1	CHD8 CHD6 CHD7	7.11e-05	28	54	3	PS00598
Domain	CHROMO_2	CHD8 CHD6 CHD7	7.11e-05	28	54	3	PS50013
Domain	SNF2_N	CHD8 CHD6 CHD7	1.07e-04	32	54	3	IPR000330
Domain	Chromodomain-like	CHD8 CHD6 CHD7	1.07e-04	32	54	3	IPR016197
Domain	SNF2_N	CHD8 CHD6 CHD7	1.07e-04	32	54	3	PF00176
Domain	Chromo/shadow_dom	CHD8 CHD6 CHD7	1.17e-04	33	54	3	IPR000953
Domain	CHROMO	CHD8 CHD6 CHD7	1.17e-04	33	54	3	SM00298
Domain	DNA/RNA_helicase_DEAH_CS	CHD8 CHD6 CHD7	1.40e-04	35	54	3	IPR002464
Domain	DEAH_ATP_HELICASE	CHD8 CHD6 CHD7	1.79e-04	38	54	3	PS00690
Domain	WHTH_DNA-bd_dom	UBR2 RAPGEF4 DEPDC1 RFX1 FOXJ3	6.61e-04	242	54	5	IPR011991
Domain	DEP	RAPGEF4 DEPDC1	1.83e-03	22	54	2	PF00610
Domain	FCH	SRGAP2C SRGAP2	1.83e-03	22	54	2	PF00611
Domain	DEP	RAPGEF4 DEPDC1	1.83e-03	22	54	2	PS50186
Domain	DEP	RAPGEF4 DEPDC1	1.83e-03	22	54	2	SM00049
Domain	FCH	SRGAP2C SRGAP2	1.83e-03	22	54	2	SM00055
Domain	DEP_dom	RAPGEF4 DEPDC1	2.00e-03	23	54	2	IPR000591
Domain	FCH_dom	SRGAP2C SRGAP2	2.00e-03	23	54	2	IPR001060
Domain	F_BAR	SRGAP2C SRGAP2	2.36e-03	25	54	2	IPR031160
Domain	F_BAR	SRGAP2C SRGAP2	2.36e-03	25	54	2	PS51741
Domain	-	RAPGEF4 DEPDC1 RFX1 FOXJ3	3.62e-03	218	54	4	1.10.10.10
Domain	Helicase_C	CHD8 CHD6 CHD7	3.67e-03	107	54	3	PF00271
Domain	HELICc	CHD8 CHD6 CHD7	3.67e-03	107	54	3	SM00490
Domain	Helicase_C	CHD8 CHD6 CHD7	3.76e-03	108	54	3	IPR001650
Domain	HELICASE_CTER	CHD8 CHD6 CHD7	3.86e-03	109	54	3	PS51194
Domain	HELICASE_ATP_BIND_1	CHD8 CHD6 CHD7	3.86e-03	109	54	3	PS51192
Domain	DEXDc	CHD8 CHD6 CHD7	3.86e-03	109	54	3	SM00487
Domain	Helicase_ATP-bd	CHD8 CHD6 CHD7	3.96e-03	110	54	3	IPR014001
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	EEFSEC TUBB6 PPP1R10 KMT2C APPL2 DROSHA PPP1R9A CSTF1 CHD8 CHD6 SRGAP2 CHD7 APP FOXJ3 ZNF281 MED13 SCAF4	7.88e-11	1497	55	17	31527615
Pubmed	The ATP-dependent chromatin remodeling enzymes CHD6, CHD7, and CHD8 exhibit distinct nucleosome binding and remodeling activities.	CHD8 CHD6 CHD7	3.74e-09	3	55	3	28533432
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	EEFSEC TBC1D15 CHD8 CHD7 FOXJ3 ZNF281 CREBBP	2.71e-08	197	55	7	20811636
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	PPP1R10 OTUD5 CIP2A FANCL RFX1 ZNF281 CREBBP MED13	5.55e-07	453	55	8	29656893
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ZNF821 APPL2 DROSHA UBQLN4 RAPGEF4 CHD6 SRGAP2 PLCG1 APP CREBBP MED13 ZIC3	6.20e-07	1285	55	12	35914814
Pubmed	SRGAP2 and Its Human-Specific Paralog Co-Regulate the Development of Excitatory and Inhibitory Synapses.	SRGAP2C SRGAP2	2.46e-06	2	55	2	27373832
Pubmed	CHD8 interacts with CHD7, a protein which is mutated in CHARGE syndrome.	CHD8 CHD7	2.46e-06	2	55	2	20453063
Pubmed	Colorectal carcinomas with CpG island methylator phenotype 1 frequently contain mutations in chromatin regulators.	CHD8 CHD7	2.46e-06	2	55	2	24211491
Pubmed	Genetic deletion of TRPA1 receptor attenuates amyloid beta- 1-42 (Aβ1-42)-induced neurotoxicity in the mouse basal forebrain in vivo.	TRPA1 APP	2.46e-06	2	55	2	32473171
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PLEKHG4B UBR2 KMT2C SGSM1 KIAA1217 PPP1R9A CHD6 SRGAP2 PLCG1 APP FOXJ3 CREBBP	2.88e-06	1489	55	12	28611215
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	KMT2C KIAA1217 CHD7 ZNF281 ZIC3	3.58e-06	146	55	5	23892456
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	TBC1D15 CIP2A UBQLN4 CHD8 CHD6 CHD7 RFX1	4.25e-06	418	55	7	34709266
Pubmed	Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation.	SRGAP2C SRGAP2	7.36e-06	3	55	2	22559944
Pubmed	Oligodendrocyte precursor survival and differentiation requires chromatin remodeling by Chd7 and Chd8.	CHD8 CHD7	7.36e-06	3	55	2	30108144
Pubmed	Positive feedback regulation of PLCgamma1/Ca(2+) signaling by PKCtheta in restimulated T cells via a Tec kinase-dependent pathway.	PRKCQ PLCG1	7.36e-06	3	55	2	15214048
Pubmed	CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer's Disease.	CIP2A APP	7.36e-06	3	55	2	30021167
Pubmed	Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C.	PRKCQ PLCG1	7.36e-06	3	55	2	11956228
Pubmed	Autism-linked CHD gene expression patterns during development predict multi-organ disease phenotypes.	CHD8 CHD7	7.36e-06	3	55	2	30277262
Pubmed	Human transcription factor protein interaction networks.	KMT2C FBN2 CSTF1 CHD8 CHD6 CHD7 RFX1 ZNF281 CREBBP SCAF4 ZIC3	1.23e-05	1429	55	11	35140242
Pubmed	Evolution of human-specific neural SRGAP2 genes by incomplete segmental duplication.	SRGAP2C SRGAP2	1.47e-05	4	55	2	22559943
Pubmed	MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.	KMT2C CREBBP	1.47e-05	4	55	2	28398509
Pubmed	Identification and characterization of FAM124B as a novel component of a CHD7 and CHD8 containing complex.	CHD8 CHD7	1.47e-05	4	55	2	23285124
Pubmed	Interaction network of human early embryonic transcription factors.	KMT2C CHD8 CHD7 APP ZNF281 CREBBP	1.93e-05	351	55	6	38297188
Pubmed	Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex.	SLC32A1 CELF4 PPP1R9A	2.36e-05	35	55	3	37758766
Pubmed	Candidate genes investigation for severe nonalcoholic fatty liver disease based on bioinformatics analysis.	UBQLN4 APP	2.45e-05	5	55	2	28796060
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	PPP1R10 KMT2C TBC1D15 CHD8 RFX1 CREBBP SCAF4	2.48e-05	549	55	7	38280479
Pubmed	USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation.	OTUD5 KIAA1217 CSTF1	2.80e-05	37	55	3	32133736
Pubmed	CHARGE and Kabuki syndromes: a phenotypic and molecular link.	CHD8 CHD7	3.67e-05	6	55	2	24705355
Pubmed	Functional proteomics mapping of a human signaling pathway.	PPP1R10 FBN2 DROSHA UBQLN4 CHD6 RFX1 CREBBP	3.95e-05	591	55	7	15231748
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	PPP1R10 CHD8 CHD6 CHD7 RFX1 FOXJ3 ZNF281	4.73e-05	608	55	7	36089195
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	EEFSEC KMT2C CHD8 CHD7 RFX1 FOXJ3 ZNF281 CREBBP SCAF4	5.38e-05	1103	55	9	34189442
Pubmed	The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.	PRKCQ PLCG1 APP	5.41e-05	46	55	3	23793062
Pubmed	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	KMT2C CELF4 PRKCQ APP RAB3C	6.30e-05	265	55	5	19240061
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	C1GALT1C1 CHD6 CHD7 RFX1 FOXJ3 ZNF281 CREBBP	6.40e-05	638	55	7	31182584
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	CHD8 CHD7 ZNF281 CREBBP MED13	6.65e-05	268	55	5	33640491
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	PPP1R10 KMT2C CHD8 CHD6 CHD7 ZNF281	9.65e-05	469	55	6	27634302
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	CHD8 CHD6 CHD7 CREBBP	1.14e-04	157	55	4	30186101
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TUBB6 KIAA1217 PPP1R9A RAPGEF4 CHD8 SRGAP2 CHD7 RAB3C	1.29e-04	963	55	8	28671696
Pubmed	Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.	KMT2C ZNF281	1.89e-04	13	55	2	17761849
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	EEFSEC UBR2 PPP1R10 CIP2A APP CREBBP	1.93e-04	533	55	6	25544563
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	ZNF821 FBN2 KIAA1217	1.98e-04	71	55	3	33541421
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	KIAA1217 CHD7 NIPAL3 FOXJ3 MED13 SCAF4	1.99e-04	536	55	6	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	KIAA1217 CHD7 NIPAL3 FOXJ3 MED13 SCAF4	2.03e-04	538	55	6	10512203
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	TUBB6 PPP1R10 CHD8 RFX1 ZNF281	2.05e-04	341	55	5	32971831
Pubmed	Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.	KMT2C CREBBP	2.21e-04	14	55	2	12482968
Pubmed	Mapping of quantitative trait loci determining NK cell-mediated resistance to MHC class I-deficient bone marrow grafts in perforin-deficient mice.	PRKCQ PLCG1	2.54e-04	15	55	2	17114464
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	TUBB6 KIAA1217 PPP1R9A SRGAP2 SCAF4	2.63e-04	360	55	5	33111431
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	ZNF821 CHD6 SRGAP2 CHD7 MOCS1	2.73e-04	363	55	5	14691545
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	KMT2C ZNF821 ST3GAL2 DEPDC1 SRGAP2 CHD7 PLCG1 FOXJ3	2.88e-04	1084	55	8	11544199
Pubmed	Esophageal Atresia / Tracheoesophageal Fistula Overview – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	FANCL CHD7	2.90e-04	16	55	2	20301753
Pubmed	Excitatory neuronal CHD8 in the regulation of neocortical development and sensory-motor behaviors.	SLC32A1 CHD8	2.90e-04	16	55	2	33626347
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	OTUD5 DROSHA CIP2A KIAA1217 CHD7 CREBBP	3.27e-04	588	55	6	38580884
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TUBB6 FBN2 P3H3 DROSHA CHD8 APP ZNF281 CREBBP	3.50e-04	1116	55	8	31753913
Pubmed	N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.	PPP1R10 KMT2C OTUD5 ST3GAL2	3.92e-04	217	55	4	34048709
Pubmed	An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.	CREBBP MED13	4.13e-04	19	55	2	16799563
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	KMT2C CHD8 CHD6 CHD7	4.49e-04	225	55	4	12168954
Pubmed	BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.	CIP2A ECHDC1 CHD7 APP ZNF281	5.25e-04	419	55	5	33001583
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	APPL2 KIAA1217 PPP1R9A SRGAP2 APP	5.37e-04	421	55	5	36976175
Pubmed	Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6.	UBR2 FANCL	5.56e-04	22	55	2	24981174
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	PPP1R10 TBC1D15 FBN2 CIP2A CHD8 RFX1 ZNF281 ZIC3	5.75e-04	1203	55	8	29180619
Pubmed	Composite co-activator ARC mediates chromatin-directed transcriptional activation.	CREBBP MED13	6.08e-04	23	55	2	10235267
Pubmed	Identification of potential target genes for RFX4_v3, a transcription factor critical for brain development.	FZD10 ZIC3	6.08e-04	23	55	2	16893423
Pubmed	Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.	PRKCQ PLCG1	6.63e-04	24	55	2	10843712
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	PPP1R10 KMT2C CHD8 SCAF4	6.77e-04	251	55	4	31076518
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	TUBB6 PPP1R9A RAPGEF4 RAB3C	6.77e-04	251	55	4	27507650
Pubmed	TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.	CHD8 CHD6 CHD7	6.98e-04	109	55	3	33554859
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	PPP1R10 KMT2C TBC1D15 CIP2A CSTF1 SRGAP2	7.52e-04	689	55	6	36543142
Pubmed	Developmental origins for semilunar valve stenosis identified in mice harboring congenital heart disease-associated GATA4 mutation.	FZD10 CREBBP	7.79e-04	26	55	2	31138536
Pubmed	USP7 Regulates Cytokinesis through FBXO38 and KIF20B.	OTUD5 CHD8 ZNF281	8.36e-04	116	55	3	30804394
Pubmed	ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.	CHD6 CREBBP	8.40e-04	27	55	2	17525332
Pubmed	Mechanism of HIV-1-TAT induction of interleukin-1beta from human monocytes: Involvement of the phospholipase C/protein kinase C signaling cascade.	PRKCQ PLCG1	8.40e-04	27	55	2	20336759
Pubmed	Identification of proteins that interact with alpha A-crystallin using a human proteome microarray.	UBR2 APPL2 RAB3C	8.78e-04	118	55	3	24453475
Pubmed	Genomic analysis of mouse retinal development.	SLC32A1 PPP1R10 ZNF821 VOPP1 APPL2 RFX1 ZIC3	1.00e-03	1006	55	7	15226823
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	PPP1R9A RAPGEF4 SRGAP2 RAB3C	1.03e-03	281	55	4	28706196
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	CHD8 CHD6 CHD7 RFX1	1.04e-03	282	55	4	23667531
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	PPP1R10 CHD8 CHD7 ZNF281	1.06e-03	283	55	4	30585729
Pubmed	Identification and characterization of a novel human PP1 phosphatase complex.	PPP1R10 KMT2C	1.11e-03	31	55	2	20516061
Pubmed	Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes.	CHD8 CREBBP	1.33e-03	34	55	2	30894540
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	PPP1R10 DROSHA CSTF1 CHD6 CHD7 ZNF281 SCAF4	1.53e-03	1082	55	7	38697112
Interaction	TRPT1 interactions	EEFSEC SERPINA10 APP	6.48e-06	14	54	3	int:TRPT1
Interaction	SP7 interactions	KMT2C FBN2 CHD7 RFX1 ZNF281 CREBBP SCAF4	1.60e-05	304	54	7	int:SP7
Interaction	FEV interactions	KMT2C CHD6 CHD7 RFX1 ZNF281 CREBBP	1.68e-05	203	54	6	int:FEV
Interaction	RAI2 interactions	APPL2 UBQLN4 APP	2.01e-05	20	54	3	int:RAI2
Interaction	PAX7 interactions	KMT2C CHD6 CHD7 ZNF281 CREBBP	2.02e-05	124	54	5	int:PAX7
Interaction	TERF2 interactions	EEFSEC PPP1R10 TBC1D15 CHD8 CHD7 FOXJ3 ZNF281	3.28e-05	340	54	7	int:TERF2
Interaction	FBXO38 interactions	OTUD5 CHD8 APP ZNF281 CREBBP	4.28e-05	145	54	5	int:FBXO38
Interaction	SOX7 interactions	KMT2C CHD7 APP CREBBP	6.90e-05	82	54	4	int:SOX7
Cytoband	Ensembl 112 genes in cytogenetic band chr20q12	CHD6 PLCG1	4.50e-04	26	55	2	chr20q12
GeneFamily	Rho GTPase activating proteins\|F-BAR domain containing	SRGAP2C SRGAP2	1.00e-03	23	37	2	1288
Coexpression	BENPORATH_NANOG_TARGETS	VOPP1 KIAA1217 UBQLN4 CSTF1 FZD10 FANCL ST3GAL2 RFX1 ZNF281 SCAF4 ZIC3	5.40e-06	988	55	11	M6616
Coexpression	BENPORATH_SOX2_TARGETS	PPP1R10 UBQLN4 FZD10 ST3GAL2 APP RFX1 ZNF281 SCAF4 ZIC3	2.02e-05	734	55	9	M3835
Coexpression	GSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP	PPP1R10 KMT2C CHD7 CREBBP MED13	3.81e-05	180	55	5	M8239
Coexpression	GSE22886_NAIVE_CD4_TCELL_VS_MONOCYTE_UP	APPL2 PRKCQ CHD7 PLCG1 NIPAL3	5.84e-05	197	55	5	M4504
Coexpression	GSE7852_TREG_VS_TCONV_LN_DN	CELF4 APPL2 RAPGEF4 CHD7 APP	6.13e-05	199	55	5	M5729
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	KMT2C KIAA1217 PPP1R9A RAPGEF4 CHD7 APP	1.73e-07	200	55	6	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	Control-Endothelial-Endothelial-Gen_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CPQ KIAA1217 PPP1R9A RAPGEF4 SRGAP2	4.03e-06	193	55	5	e1d546165dcc2392f540162206852c4717d7306f
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-2m-Neuronal-Interneuron\|2m / Sample Type, Dataset, Time_group, and Cell type.	SLC32A1 ZNF821 VOPP1 CELF4 RAB3C	4.79e-06	200	55	5	08bee924a2654e05df3b39e8a51f93c8b3472175
ToppCell	Sepsis-Int-URO-Lymphocyte-T/NK-dn_T\|Int-URO / Disease, condition lineage and cell class	ZNF821 C1GALT1C1 APPL2 PRKCQ NIPAL3	4.79e-06	200	55	5	020439d9e70fff7246650ab0e9105236688c3ec3
ToppCell	COVID-pDC\|COVID / Condition, Cell_class and T cell subcluster	PLEKHG4B ENAM TUBB6 APP	6.04e-05	172	55	4	3ecbb000495dde32f6153ef6bdea9c8802ff3985
ToppCell	Int-URO-Lymphocyte-T_NK-dnT\|Int-URO / Disease, Lineage and Cell Type	ZNF821 C1GALT1C1 APPL2 PRKCQ	6.04e-05	172	55	4	e70299573da1679d6d286c3a43699cbff76e207d
ToppCell	COVID-pDC-\|COVID / Condition, Cell_class and T cell subcluster	PLEKHG4B ENAM TUBB6 APP	6.04e-05	172	55	4	a7827faa1afab51fdaf0cb1a2babcd2e00d411e5
ToppCell	IIF-Myeloid-pDC\|IIF / Disease, Lineage and Cell Type	SLC32A1 ENAM TUBB6 APP	6.46e-05	175	55	4	35cfb7d0b88678ff5b83ad6e19dbc15a908a3fcc
ToppCell	E18.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF821 VOPP1 SGSM1 FZD10	6.75e-05	177	55	4	8dfadd9852e0c256363471a7cfe6af120c8c51e0
ToppCell	E18.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF821 VOPP1 SGSM1 FZD10	6.75e-05	177	55	4	767b2af5f224d100b22bed32f86cec1cd17e8711
ToppCell	E18.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF821 VOPP1 SGSM1 FZD10	6.75e-05	177	55	4	5ef2527e9b41e62f1724cdabaad9d8979266bb7d
ToppCell	E18.5-Endothelial-Endothelial_lymphatic\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF821 VOPP1 SGSM1 FZD10	6.75e-05	177	55	4	ae1d2fdd4f67f50c906b27ea084de058c6908aa2
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FBN2 TRPA1 FZD10 MOCS1	7.05e-05	179	55	4	a1ea8daa0fe8900f5a04b555c77fe8ebdaa3908d
ToppCell	3'_v3-blood-Myeloid_Dendritic-pDC\|blood / Manually curated celltypes from each tissue	PLEKHG4B SLC32A1 TUBB6 APP	7.36e-05	181	55	4	66d890a105f955dca91d6e5e6c730d1a68ee9233
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-ACTC+_SMC\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	TUBB6 FBN2 TRPA1 FSD1	7.85e-05	184	55	4	39168ca2bbf1369c9fe87c67f0aaff5e3cd03151
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TUBB6 CPQ RAPGEF4 RAB3C	8.01e-05	185	55	4	4e40d3103ebf4a7066b7ce300b6ef700ba0e2863
ToppCell	Healthy_donor-pDC\|Healthy_donor / disease group, cell group and cell class (v2)	PLEKHG4B SLC32A1 ENAM APP	8.01e-05	185	55	4	7fbb55cbdb39bdecb6063c8ba9776ab06c2666e8
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TUBB6 CPQ RAPGEF4 RAB3C	8.18e-05	186	55	4	16092819e9148dfe64f07c737652b6e533e699f7
ToppCell	control-Myeloid-pDC\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	SLC32A1 ENAM TUBB6 APP	8.18e-05	186	55	4	fe31e9cf4575ee40b50489593c51d8c36c3cc532
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TUBB6 SRGAP2C SRGAP2 CHD7	8.18e-05	186	55	4	55b239834b96b1f7787ec77a7d19796d617bbbf0
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELF4 RAPGEF4 CHD7 RAB3C	8.18e-05	186	55	4	a1ab273b01971d6a892912560d387685dd657179
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC32A1 FBN2 KIAA1217 RAB3C	8.35e-05	187	55	4	85f1678338a47d91e296f0620d4887f057eb7e70
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELF4 RAPGEF4 CHD7 RAB3C	8.35e-05	187	55	4	ef3c85c01bc3da408ae288b6e3096ad888a12e63
ToppCell	Healthy_donor-pDC\|World / disease group, cell group and cell class (v2)	PLEKHG4B SLC32A1 ENAM APP	8.35e-05	187	55	4	aa2cc54487d3c5045ac0c93560944c5a55878e27
ToppCell	3'_v3-blood-Myeloid_Dendritic\|blood / Manually curated celltypes from each tissue	PLEKHG4B SLC32A1 TUBB6 APP	8.52e-05	188	55	4	239a2162a21d3339da7c1884ab76286346fbf97f
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TUBB6 SRGAP2C VOPP1 SRGAP2	8.88e-05	190	55	4	2d54fca50593fbd11fe13fc2bfaf937a05db776d
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-Double_negative_Thymocyte,_DN4_(Cd8-,_Cd4-),_some_undergoing_VDJ_recombination_\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF821 ST3GAL2 PRKCQ ZNF281	8.88e-05	190	55	4	8f5e71a0861ee4e8f3ce45e8a7f18fb9d6036a3c
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	NOTUM PPP1R9A CHD6 MED13	9.25e-05	192	55	4	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	human_hepatoblastoma-Tumor_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	NOTUM PPP1R9A CHD6 MED13	9.43e-05	193	55	4	503a979328c68b096680b71359a26f02fafdff35
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC32A1 FBN2 KIAA1217 RAB3C	9.43e-05	193	55	4	010717ca052b6c8a525a43aaeffddea0d1113e63
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-SST-MGE1-4\|World / Primary Cells by Cluster	SLC32A1 CELF4 CHD6 CHD7	9.43e-05	193	55	4	2eb6e4cff4fe3ce564c1581f6f7df4834895aaa9
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC32A1 FBN2 KIAA1217 RAB3C	9.43e-05	193	55	4	2189da4b727e25e62669d7b9257f06493be21a27
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	NOTUM PPP1R9A CHD6 MED13	9.43e-05	193	55	4	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	Control-Endothelial-Endothelial\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KIAA1217 PPP1R9A RAPGEF4 SRGAP2	9.43e-05	193	55	4	aff0649c73c634bc6ff0dc7759b4693a9236bf05
ToppCell	Control-Endothelial\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KIAA1217 PPP1R9A RAPGEF4 SRGAP2	9.43e-05	193	55	4	c5f9fe03e64c211d4bcd4959e5b32f14841e336a
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_neural\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SLC32A1 CELF4 CHD7 RAB3C	1.02e-04	197	55	4	47c4d9de71a435119c71f5219de836cf9b2aab6d
ToppCell	(5)_Fibroblasts-(5)_Fibroblast-B_(Myofibroblast)\|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)	FBN2 NOTUM P3H3 KIAA1217	1.04e-04	198	55	4	196257c4420ac801ed9fbb444f11718adb7560ae
ToppCell	facs-Trachea-nan-3m-Mesenchymal-chondrocyte\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN2 NOTUM P3H3 FZD10	1.04e-04	198	55	4	71e847e8c24744d6df4a960348ad2ecf310373b4
ToppCell	Control-Control-Lymphocyte-T/NK-CD4+_T_activated\|Control / Disease, condition lineage and cell class	APPL2 RAPGEF4 CHD6 PLCG1	1.04e-04	198	55	4	ee71543559836fd59adc0da877b2ca538cba60cb
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	KIAA1217 PPP1R9A RAPGEF4 APP	1.08e-04	200	55	4	a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCell	Non-neuronal-Dividing-IPC\|World / Primary Cells by Cluster	TUBB6 CIP2A DEPDC1 CHD7	1.08e-04	200	55	4	971533181daa1bfac1f1b8c507d2013f891f9078
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	SLC32A1 CELF4 NOTUM CHD6	1.08e-04	200	55	4	e16bde12326f0cfc4d03f9307cba0e21ea2389cb
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC32A1 FBN2 KIAA1217 RAB3C	1.08e-04	200	55	4	107854f4855fc99c9f7e737eb246f0d868e6c5fd
ToppCell	Sepsis-Int-URO-Myeloid-tDC\|Int-URO / Disease, condition lineage and cell class	ECHDC1 CSTF1 APP RAB3C	1.08e-04	200	55	4	f5d0497a72da21cad24e0ef51c3dc4d024dbf294
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	KIAA1217 PPP1R9A RAPGEF4 APP	1.08e-04	200	55	4	b2d4e6f3e8e4da62e6b02758ab2ed8f505269f9a
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	KIAA1217 PPP1R9A RAPGEF4 APP	1.08e-04	200	55	4	eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Neuronal-Interneuron\|6m / Sample Type, Dataset, Time_group, and Cell type.	SLC32A1 CELF4 CHD7 RAB3C	1.08e-04	200	55	4	274871d632bbbe03720726a59ab3ec6d5fa0da11
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Interneuron\|10w / Sample Type, Dataset, Time_group, and Cell type.	SLC32A1 CELF4 SRGAP2 RAB3C	1.08e-04	200	55	4	f5c63ef52bd7a898cf009b8bf9b2f7f4890d1c9b
ToppCell	frontal_cortex-Non-neuronal-oligodendrocyte-Oligo-OPC_Pdgfra_Grm5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CPQ PRKCQ CHD7	5.92e-04	133	55	3	63d2f096ae47d9b587acc6c5fbd346e5e58842b8
ToppCell	MS-CD4-CD8_1\|MS / Condition, Cell_class and T cell subcluster	EEFSEC CIP2A DEPDC1	8.39e-04	150	55	3	7dc95c58b98d8c4c6c49fb1a03ec6ac24fb41f54
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Degenerative_Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TRPA1 CIP2A RAB3C	9.06e-04	154	55	3	dcbc6705e91ec744801b621e5d0733a78a7a90ca
ToppCell	343B-Lymphocytic-CD4_T-cell-Treg_cell_1\|343B / Donor, Lineage, Cell class and subclass (all cells)	UBQLN4 PLCG1 SCAF4	9.23e-04	155	55	3	a4ff78e2efc6fe9a513bb2b64e5848f2ce65a09f
ToppCell	facs-Aorta-Heart-18m-Mesenchymal-fibrocyte\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF821 CELF4 MOCS1	9.40e-04	156	55	3	5b56217336771baf57d791efcb4e206c6aea83b1
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Plch2_Dock5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SLC32A1 RAPGEF4 RAB3C	9.57e-04	157	55	3	516903469756c5fabfdf56d7bd59b3bdd7b44e39
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SLC32A1 CHD6 RAB3C	9.93e-04	159	55	3	7f29f9dcf25ffa1822b137c571e9ac16defc6292
ToppCell	Control-Endothelial_cells-Inflamed_endothelial_cells\|Control / group, cell type (main and fine annotations)	KIAA1217 RAPGEF4 APP	1.01e-03	160	55	3	958256e3d3836160763b82bb48f794087918d935
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Pericentral)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NOTUM RAPGEF4 SERPINA10	1.01e-03	160	55	3	c42bcc6c7d113f0db43febb088b75ca4ac7cb7a3
ToppCell	Children_(3_yrs)-Immune-dendritic_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ENAM VOPP1 ST3GAL2	1.05e-03	162	55	3	86a0b9dabd150dc993bfc0f3344804de7f8e4042
ToppCell	normal_Lung-Fibroblasts-Myofibroblasts\|Fibroblasts / Location, Cell class and cell subclass	PLEKHG4B FBN2 KIAA1217	1.09e-03	164	55	3	9b4a6007abae992db871d9f6f731d5af724de30d
ToppCell	ICU-SEP-Lymphocyte-T_NK-MAIT\|ICU-SEP / Disease, Lineage and Cell Type	FANCL FSD1 PLCG1	1.09e-03	164	55	3	db863a44fc0dad5518c47fdbf64ea21d6f36f089
ToppCell	Int-URO-Myeloid-tDC\|Int-URO / Disease, Lineage and Cell Type	CSTF1 APP RAB3C	1.10e-03	165	55	3	9803c3db6cdcf925bea7d9c382bf4fd05acf3509
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal-ventral_progenitors_and_neurons_1\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	SLC32A1 CELF4 SGSM1	1.10e-03	165	55	3	9795ce31689bc63f5a2d68725ef00b23a90c3846
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5\|TCGA-Ovary / Sample_Type by Project: Shred V9	PPP1R9A RFX1 FOXJ3	1.12e-03	166	55	3	32d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CIP2A DEPDC1 PRKCQ	1.12e-03	166	55	3	a41a20cef053c67da2d435e3e132ce28f1661c03
ToppCell	10x5'-Lung-Hematopoietic_progenitors\|Lung / Manually curated celltypes from each tissue	FBN2 CIP2A DEPDC1	1.14e-03	167	55	3	dec18caf0475002d4ad3c7bc7fc3050cbc8e6bae
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SRGAP2C SGSM1 SRGAP2	1.14e-03	167	55	3	942134bbabe9972fae80cbc4ed4e94da52f55dc3
ToppCell	Control-Myeloid-MoAM1,_IL1R2\|Control / Condition, Lineage and Cell class	SRGAP2C FBN2 SRGAP2	1.14e-03	167	55	3	ab6029ba037b6a499da8758864c44e174cde5587
ToppCell	10x5'-Lung-Hematopoietic_progenitors-Cycling_pre-Myeloid-2\|Lung / Manually curated celltypes from each tissue	FBN2 CIP2A DEPDC1	1.14e-03	167	55	3	82739226347d74897be000f429b73543a031af96
ToppCell	Tuft-tuft-1\|World / Class top	CPQ PPP1R9A FZD10	1.16e-03	168	55	3	8ddc2ec483ed2c6c0fb2ae521c6861ceb6d32e34
ToppCell	Bronchial_Biopsy-Immune-T_and_NK\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	RAPGEF4 DEPDC1 PLCG1	1.16e-03	168	55	3	435b2f238fbb3f50427e8cdecf2220615015153c
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-T_cells-NK_T_cell\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NOTUM OTUD5 FSD1	1.16e-03	168	55	3	b4b73f3fc9f4c3d87ca0a63ff8b2842141ccd0e6
ToppCell	droplet-Lung-nan-3m-Lymphocytic-Proliferating_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC32A1 DEPDC1 PRKCQ	1.18e-03	169	55	3	f6a6d2f614d60395ad9b867ff1cf59eba72b04ce
ToppCell	BAL-Control-Lymphocyte-T/NK-NK_cell\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PPP1R9A FSD1 PRKCQ	1.18e-03	169	55	3	d375a1df1ecc938f66bad92e54b8cda26ca9c472
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CELF4 RAPGEF4 APP	1.18e-03	169	55	3	987ff79ad563825dd9877ea8ccb536758f8c6700
ToppCell	Frontal_cortex-Neuronal-Inhibitory\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SLC32A1 CHD6 RAB3C	1.18e-03	169	55	3	78eb70dd916724e476eabccf18fb7fcec4210308
ToppCell	BAL-Control-Lymphocyte-T/NK-NK_cell-NK\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PPP1R9A FSD1 PRKCQ	1.18e-03	169	55	3	58f805c0be507bd5fadc9ea3555032daabbc8ab8
ToppCell	BAL-Control-Lymphocyte-T/NK-NK_cell-NK-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PPP1R9A FSD1 PRKCQ	1.18e-03	169	55	3	e9c0e0f4c421c7bdbf1a7e33002f3cf22ea307cb
ToppCell	droplet-Lung-nan-3m-Lymphocytic-T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC32A1 DEPDC1 PRKCQ	1.18e-03	169	55	3	df2c9c706bfc9db2bc5726602a49f5f5a94e9481
ToppCell	Immune-dendritic_cell\|World / Lineage, Cell type, age group and donor	ENAM VOPP1 ST3GAL2	1.22e-03	171	55	3	6a9e2e2d3e1d8cc475bf9765129bc4a32da3b8ea
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NOTUM RAPGEF4 FZD10	1.22e-03	171	55	3	a4a2c5dc995589fbe3d4ca6ee1df888807e4ae34
ToppCell	metastatic_Lymph_Node-Myeloid_cells-pDCs\|metastatic_Lymph_Node / Location, Cell class and cell subclass	SLC32A1 ST3GAL2 APP	1.22e-03	171	55	3	1f8e66073088fc1969782e443bf00f8c1877ea91
ToppCell	Children_(3_yrs)-Immune-dendritic_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ENAM VOPP1 ST3GAL2	1.22e-03	171	55	3	6a5ac0f56bd7b4543be103100fb735ca6bc5b8bf
ToppCell	3'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-D_cells_(SST+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CELF4 RAPGEF4 SERPINA10	1.22e-03	171	55	3	fa5cc720bd0045d0307439be547b41d56def5b43
ToppCell	mild_COVID-19-pDC\|World / disease group, cell group and cell class (v2)	PLEKHG4B SLC32A1 APP	1.24e-03	172	55	3	dab2f1a05c7df58d9387b13271b3f1f1583f9ac3
ToppCell	URO-Lymphocyte-B-Plasmablast\|URO / Disease, Lineage and Cell Type	ENAM CIP2A DEPDC1	1.24e-03	172	55	3	48888ef50ac784b38aca81da68f8a94ce09c670d
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC32A1 SERPINA10 RAB3C	1.27e-03	173	55	3	07798461d12d04f3dabff03481c999cb07c5af2f
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ECHDC1 RAPGEF4 FOXJ3	1.27e-03	173	55	3	4968712af1cca8c932abd3323631d7dcaffd4a66
ToppCell	Endothelial-B-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	RAPGEF4 FZD10 PLCG1	1.27e-03	173	55	3	a81992965137195d20fc498f750975303961a828
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4/8-lo-Cycling_T\|GI_small-bowel / Manually curated celltypes from each tissue	CIP2A DEPDC1 SERPINA10	1.29e-03	174	55	3	e4c8da80eca07e4396f57dad212f76c2eca4c1bd
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CIP2A DEPDC1 SRGAP2	1.29e-03	174	55	3	72df66319f6efbd88ecf439013d97409fbf3cb52
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CIP2A DEPDC1 SRGAP2	1.29e-03	174	55	3	c6087fd0e036ec7f40f0f8f17d1f6ce13ddb5235
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_A2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TUBB6 SRGAP2C OTUD5	1.31e-03	175	55	3	334fad1a147de6c007cec5089c02c35cf3220f1b
ToppCell	nucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-pDC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SLC32A1 ENAM APP	1.31e-03	175	55	3	37c2d4e0b6e9a3171931797ce9a54f3347288e57
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_dendritic-plasmacytoid_dendritic_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SLC32A1 ENAM APP	1.31e-03	175	55	3	97fe431f224b592b3076632d101e19136c138dcc
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELF4 RAPGEF4 RAB3C	1.31e-03	175	55	3	65571d775d26a40e979dbf290a8e4320c0d9fb3f
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_A2\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	TUBB6 SRGAP2C OTUD5	1.31e-03	175	55	3	da191dfb8a7f976a632a3a0b923942ab54f5c8c1
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TUBB6 P3H3 CIP2A	1.31e-03	175	55	3	3e56695a9db97cb1d3503425c48eb79bbf99213e
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CIP2A DEPDC1 PRKCQ	1.31e-03	175	55	3	9de288c338cee67be0e9b836c87799bbc1db1c38
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D122\|Adult / Lineage, Cell type, age group and donor	KIAA1217 ECHDC1 PPP1R9A	1.33e-03	176	55	3	3fee8a367bb9755aca1b7fcc968b08e51b6e9436
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-neuro-epithelial\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC32A1 SERPINA10 RAB3C	1.33e-03	176	55	3	fb718a6b07aa5d56600263280afa530bcb63db42
Disease	CHARGE syndrome (implicated_via_orthology)	CHD8 CHD6 CHD7	2.13e-07	7	55	3	DOID:0050834 (implicated_via_orthology)
Disease	congenital heart disease (implicated_via_orthology)	KMT2C CHD8 CHD6 CHD7	8.53e-06	69	55	4	DOID:1682 (implicated_via_orthology)
Disease	Sezary Syndrome	KMT2C PLCG1 CREBBP	1.74e-05	27	55	3	C0036920
Disease	Carcinoma, Transitional Cell	KMT2C CHD6 CREBBP	6.21e-05	41	55	3	C0007138
Disease	oral microbiome measurement	KMT2C APPL2 KIAA1217	6.68e-05	42	55	3	EFO_0801229
Disease	autism spectrum disorder (implicated_via_orthology)	CHD8 CHD6 CHD7 CREBBP	1.88e-04	152	55	4	DOID:0060041 (implicated_via_orthology)
Disease	Leukemia, Myelocytic, Acute	KMT2C VOPP1 FANCL CREBBP	3.08e-04	173	55	4	C0023467
Disease	Granulomatous Slack Skin	PRKCQ PLCG1	7.69e-04	22	55	2	C0376407
Disease	Lymphoma, T-Cell, Cutaneous	PRKCQ PLCG1	8.42e-04	23	55	2	C0079773
Disease	Prostatic Neoplasms	KMT2C APPL2 CHD6 CHD7 NIPAL3 CREBBP	9.83e-04	616	55	6	C0033578
Disease	Malignant neoplasm of prostate	KMT2C APPL2 CHD6 CHD7 NIPAL3 CREBBP	9.83e-04	616	55	6	C0376358
Disease	hearing threshold measurement	SLC32A1 SGSM1	1.25e-03	28	55	2	EFO_0007618

Protein segments in the cluster

Peptide	Gene	Start	Entry
AGHTNMPNLLNTMME	CHD8	1076	Q9HCK8
HGDTMTVMDPKQMNV	CPQ	436	Q9Y646
EPQIAMFCGRLNMHM	APP	31	P05067
SFMHSMDPQLERQME	DNM1P46	41	Q6ZS02
MGAHTNNMMAQAPAQ	CREBBP	776	Q92793
VTFNGLTPNQMHVMM	C1GALT1C1	276	Q96EU7
HLMDQPNRMMSNTPG	CHD7	81	Q9P2D1
GHPQHMQQMGSYMAR	CHD7	181	Q9P2D1
MRHEAPMQMASAQDA	RAB3C	1	Q96E17
FVANPMHLQMREDMA	P3H3	181	Q8IVL6
MDQNMFRNFSFMNPG	PRKCQ	686	Q04759
GMQNMHDKGMTVQPE	NIPAL3	341	Q6P499
QQRMEMEQHGMVGSE	KMT2C	3426	Q8NEZ4
NPSRMNAFSGVMMLQ	ECHDC1	71	Q9NTX5
NMSHLMVDFAQERQM	FSD1	141	Q9BTV5
RMSQNVDMPKLHDAM	DEPDC1	626	Q5TB30
HMQMSMAVGQQALPL	MAS1L	61	P35410
HAGMFSISQMKNRPM	MOCS1	366	Q9NZB8
FLMHMGFDMQTVAQP	NOTUM	466	Q6P988
GYNMTRMPNLMGHEN	FZD10	46	Q9ULW2
GMGMALPAMQQARHS	CHD6	2631	Q8TD26
NQQHMMPSQAFQMRR	FOXJ3	591	Q9UPW0
MMEPMIGFAHGQINF	APPL2	196	Q8NEU8
EMMRYNQFNFMNGPH	ENAM	56	Q9NRM1
PEYMQVNGGHNCMDM	FBN2	1721	P35556
MMNETAQQNMENHPV	CSTF1	151	Q05048
FQPRMMGIQQDPMHH	SCAF4	341	O95104
NHIEMQAMAEMYNRP	OTUD5	281	Q96G74
MMQGNTCHRMSFHPG	DROSHA	1	Q9NRR4
NDFIMMHCVFMPNTQ	RAPGEF4	531	Q8WZA2
QQRMQHSPDLMSFMM	FANCL	71	Q9NW38
MEDQQHMAMRGQPFS	RFX1	521	P22670
NHTPKTMNGDMRMQR	KIAA1217	271	Q5T5P2
DGHNFIMRMNQAPTV	ST3GAL2	171	Q16842
MKFEFQPHMGDMASQ	SRGAP2C	341	P0DJJ0
EQHIMGFSPMNMNNK	MED13	841	Q9UHV7
NPMAAFAAAQMQQMA	CELF4	286	Q9BZC1
QLRHMLTQMMFEQSP	CIP2A	311	Q8TCG1
PMNMNMGVNVAAHHG	ZIC3	221	O60481
GMNPVGNSMAMAFQV	VOPP1	126	Q96AW1
QMFHMPITSAMQGDR	EEFSEC	271	P57772
MMAPLHIAVQGMNNE	TRPA1	131	O75762
QQMFDARNMMAACDP	TUBB6	291	Q9BUF5
QEMASMGIGNQPFMD	PLEKHG4B	1116	Q96PX9
MKFEFQPHMGDMASQ	SRGAP2	341	O75044
EMEPTFPQGMVMFNH	ZNF281	41	Q9Y2X9
PMQMNQALFMTGRHC	PLCG1	1046	P19174
MKRMNQNFPHGGAMD	SGSM1	1006	Q2NKQ1
MDQMHQNFEEQMQGM	TBC1D15	481	Q8TC07
SMRHDGNMVFSPFGM	SERPINA10	91	Q9UK55
MMLRAQFGQDPSAMA	ZNF821	361	O75541
LEGNMQQPSEFHCMM	SLC32A1	326	Q9H598
VMLQTGVSMMDPNHF	UBR2	696	Q8IWV8
MAQMSEMQRHFIDEN	UBR2	1046	Q8IWV8
SHMLNNPELMRQTME	UBQLN4	236	Q9NRR5
MSNRPVCRHFMMKGN	PPP1R10	906	Q96QC0
MQMGMEPNENAAVIA	PPP1R9A	71	Q9ULJ8