| Category | Name | IntersectionWithQuery | PValue | GenesInTerm | GenesInQuery | GenesInTermInQuery | ID |
|---|---|---|---|---|---|---|---|
| GeneOntologyMolecularFunction | ubiquitin-like protein transferase activity | RGPD4 RNF144B RAG1 VPS18 RBBP6 TRIM31 PEX10 ZSWIM2 UBE2D1 UBE2D2 UBE2D3 BRCA1 UBE2D4 UBR5 TRIM56 RGPD3 LONRF2 PML | 1.06e-10 | 512 | 102 | 18 | GO:0019787 |
| GeneOntologyMolecularFunction | ubiquitin-like protein ligase activity | RGPD4 RNF144B RAG1 VPS18 RBBP6 TRIM31 PEX10 ZSWIM2 UBE2D1 UBE2D2 UBE2D3 UBR5 TRIM56 RGPD3 LONRF2 PML | 1.83e-10 | 398 | 102 | 16 | GO:0061659 |
| GeneOntologyMolecularFunction | aminoacyltransferase activity | RGPD4 RNF144B RAG1 VPS18 RBBP6 TRIM31 PEX10 ZSWIM2 UBE2D1 UBE2D2 UBE2D3 BRCA1 UBE2D4 UBR5 TRIM56 RGPD3 LONRF2 PML | 1.96e-10 | 532 | 102 | 18 | GO:0016755 |
| GeneOntologyMolecularFunction | acyltransferase activity | RGPD4 RNF144B RAG1 VPS18 RBBP6 TRIM31 PEX10 ZSWIM2 SIRT1 UBE2D1 UBE2D2 UBE2D3 BRCA1 UBE2D4 UBR5 TRIM56 RGPD3 LONRF2 PML | 1.20e-08 | 775 | 102 | 19 | GO:0016746 |
| GeneOntologyMolecularFunction | ubiquitin-protein transferase activity | RNF144B RAG1 VPS18 RBBP6 TRIM31 PEX10 ZSWIM2 UBE2D1 UBE2D2 UBE2D3 BRCA1 UBE2D4 UBR5 TRIM56 LONRF2 | 1.76e-08 | 473 | 102 | 15 | GO:0004842 |
| GeneOntologyMolecularFunction | ubiquitin protein ligase activity | RNF144B RAG1 VPS18 RBBP6 TRIM31 PEX10 ZSWIM2 UBE2D1 UBE2D2 UBE2D3 UBR5 TRIM56 LONRF2 | 5.54e-08 | 372 | 102 | 13 | GO:0061630 |
| GeneOntologyMolecularFunction | ubiquitin conjugating enzyme activity | 3.72e-05 | 37 | 102 | 4 | GO:0061631 | |
| GeneOntologyMolecularFunction | ubiquitin-like protein conjugating enzyme activity | 6.80e-05 | 43 | 102 | 4 | GO:0061650 | |
| GeneOntologyMolecularFunction | transcription coregulator activity | LIMD1 TRIM31 DYRK1A KMT2E SIRT1 MED15 BRCA1 ARID5B CAMTA1 PML | 6.03e-04 | 562 | 102 | 10 | GO:0003712 |
| GeneOntologyMolecularFunction | zinc ion binding | RNF144B RAG1 EPRS1 RBBP6 TRIM31 PEX10 ZSWIM2 BRCA1 UBR5 TRIM56 FBXO43 CDA PML | 6.04e-04 | 891 | 102 | 13 | GO:0008270 |
| GeneOntologyMolecularFunction | SUMO transferase activity | 8.17e-04 | 36 | 102 | 3 | GO:0019789 | |
| GeneOntologyMolecularFunction | transcription coactivator activity | 9.33e-04 | 303 | 102 | 7 | GO:0003713 | |
| GeneOntologyBiologicalProcess | protein polyubiquitination | RNF144B TRIM31 PEX10 ZSWIM2 UBE2D1 UBE2D2 UBE2D3 BRCA1 UBE2D4 UBR5 TRIM56 | 2.15e-07 | 289 | 103 | 11 | GO:0000209 |
| GeneOntologyBiologicalProcess | protein K29-linked ubiquitination | 4.05e-07 | 13 | 103 | 4 | GO:0035519 | |
| GeneOntologyBiologicalProcess | protein modification by small protein conjugation | RNF144B RAG1 VPS18 RBBP6 TRIM31 PEX10 ZSWIM2 COPS3 SIRT1 UBE2D1 UBE2D2 UBE2D3 BRCA1 UBE2D4 UBR5 TRIM56 FBXO43 PML | 4.11e-07 | 893 | 103 | 18 | GO:0032446 |
| GeneOntologyBiologicalProcess | protein K6-linked ubiquitination | 1.33e-06 | 17 | 103 | 4 | GO:0085020 | |
| GeneOntologyBiologicalProcess | post-translational protein modification | RNF144B RAG1 VPS18 RBBP6 PARP8 TRIM31 PEX10 ZSWIM2 COPS3 SIRT1 UBE2D1 UBE2D2 UBE2D3 BRCA1 UBE2D4 UBR5 TRIM56 FBXO43 PML | 1.34e-06 | 1074 | 103 | 19 | GO:0043687 |
| GeneOntologyBiologicalProcess | protein modification by small protein conjugation or removal | RNF144B RAG1 VPS18 RBBP6 TRIM31 PEX10 ZSWIM2 COPS3 SIRT1 UBE2D1 UBE2D2 UBE2D3 BRCA1 UBE2D4 UBR5 TRIM56 FBXO43 PML | 2.36e-06 | 1009 | 103 | 18 | GO:0070647 |
| GeneOntologyBiologicalProcess | protein ubiquitination | RNF144B RAG1 VPS18 RBBP6 TRIM31 PEX10 ZSWIM2 SIRT1 UBE2D1 UBE2D2 UBE2D3 BRCA1 UBE2D4 UBR5 TRIM56 FBXO43 | 2.58e-06 | 811 | 103 | 16 | GO:0016567 |
| GeneOntologyBiologicalProcess | protein K48-linked ubiquitination | 1.09e-05 | 100 | 103 | 6 | GO:0070936 | |
| GeneOntologyBiologicalProcess | protein K11-linked ubiquitination | 3.41e-05 | 37 | 103 | 4 | GO:0070979 | |
| GeneOntologyBiologicalProcess | protein catabolic process | RNF144B RBBP6 TRIM31 PEX10 COPS3 DENND3 SIRT1 ADAMTS12 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBR5 FBXO43 IRAK3 C4BPA PML | 3.57e-05 | 1115 | 103 | 17 | GO:0030163 |
| GeneOntologyBiologicalProcess | protein K63-linked ubiquitination | 3.93e-05 | 76 | 103 | 5 | GO:0070534 | |
| GeneOntologyBiologicalProcess | protein K27-linked ubiquitination | 4.23e-05 | 14 | 103 | 3 | GO:0044314 | |
| GeneOntologyBiologicalProcess | negative regulation of intracellular steroid hormone receptor signaling pathway | 4.67e-05 | 40 | 103 | 4 | GO:0033144 | |
| GeneOntologyBiologicalProcess | negative regulation of intracellular estrogen receptor signaling pathway | 5.27e-05 | 15 | 103 | 3 | GO:0033147 | |
| GeneOntologyBiologicalProcess | ubiquitin-dependent protein catabolic process | RNF144B RBBP6 TRIM31 PEX10 COPS3 SIRT1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBR5 PML | 8.36e-05 | 640 | 103 | 12 | GO:0006511 |
| GeneOntologyBiologicalProcess | modification-dependent protein catabolic process | RNF144B RBBP6 TRIM31 PEX10 COPS3 SIRT1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBR5 PML | 9.82e-05 | 651 | 103 | 12 | GO:0019941 |
| GeneOntologyBiologicalProcess | modification-dependent macromolecule catabolic process | RNF144B RBBP6 TRIM31 PEX10 COPS3 SIRT1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBR5 PML | 1.06e-04 | 656 | 103 | 12 | GO:0043632 |
| GeneOntologyBiologicalProcess | proteolysis involved in protein catabolic process | RNF144B RBBP6 TRIM31 PEX10 COPS3 SIRT1 ADAMTS12 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBR5 PML | 2.02e-04 | 812 | 103 | 13 | GO:0051603 |
| GeneOntologyBiologicalProcess | regulation of complement activation | 3.24e-04 | 27 | 103 | 3 | GO:0030449 | |
| MousePheno | elevated level of mitotic sister chromatid exchange | 1.72e-06 | 16 | 80 | 4 | MP:0003701 | |
| Domain | Znf_RING/FYVE/PHD | RNF144B RAG1 RBBP6 RSF1 TRIM31 PEX10 ZSWIM2 KMT2E RNF17 ZFYVE9 BRCA1 TRIM56 WDFY3 LONRF2 PML | 3.24e-08 | 459 | 103 | 15 | IPR013083 |
| Domain | ZF_RING_1 | RNF144B RAG1 VPS18 RBBP6 TRIM31 PEX10 ZSWIM2 RNF17 BRCA1 TRIM56 LONRF2 PML | 7.06e-08 | 291 | 103 | 12 | PS00518 |
| Domain | ZF_RING_2 | RNF144B RAG1 VPS18 RBBP6 TRIM31 PEX10 ZSWIM2 RNF17 BRCA1 TRIM56 LONRF2 PML | 9.15e-08 | 298 | 103 | 12 | PS50089 |
| Domain | - | RNF144B RAG1 RBBP6 RSF1 TRIM31 PEX10 ZSWIM2 KMT2E ZFYVE9 BRCA1 TRIM56 WDFY3 LONRF2 PML | 1.72e-07 | 449 | 103 | 14 | 3.30.40.10 |
| Domain | Znf_RING | RNF144B RAG1 VPS18 RBBP6 TRIM31 PEX10 ZSWIM2 RNF17 BRCA1 TRIM56 LONRF2 PML | 2.41e-07 | 326 | 103 | 12 | IPR001841 |
| Domain | Znf_RING_CS | 2.93e-07 | 163 | 103 | 9 | IPR017907 | |
| Domain | RING | RNF144B RAG1 RBBP6 TRIM31 PEX10 ZSWIM2 RNF17 BRCA1 TRIM56 LONRF2 PML | 9.67e-07 | 305 | 103 | 11 | SM00184 |
| Domain | UBQ-conjugating_AS | 1.01e-05 | 25 | 103 | 4 | IPR023313 | |
| Domain | zf-C3HC4 | 3.27e-05 | 223 | 103 | 8 | PF00097 | |
| Domain | UQ_con | 6.19e-05 | 39 | 103 | 4 | PF00179 | |
| Domain | UBIQUITIN_CONJUGAT_1 | 6.84e-05 | 40 | 103 | 4 | PS00183 | |
| Domain | UBIQUITIN_CONJUGAT_2 | 7.55e-05 | 41 | 103 | 4 | PS50127 | |
| Domain | UBQ-conjugat_E2 | 7.55e-05 | 41 | 103 | 4 | IPR000608 | |
| Domain | - | 1.79e-04 | 51 | 103 | 4 | 3.10.110.10 | |
| Domain | UBQ-conjugating_enzyme/RWD | 2.08e-04 | 53 | 103 | 4 | IPR016135 | |
| Domain | PWWP | 2.66e-04 | 23 | 103 | 3 | PF00855 | |
| Domain | PWWP_dom | 2.66e-04 | 23 | 103 | 3 | IPR000313 | |
| Domain | PWWP | 3.03e-04 | 24 | 103 | 3 | PS50812 | |
| Domain | Znf_C3HC4_RING-type | 3.82e-04 | 172 | 103 | 6 | IPR018957 | |
| Domain | TSP_1 | 4.05e-04 | 63 | 103 | 4 | PF00090 | |
| Domain | TSP1 | 4.56e-04 | 65 | 103 | 4 | SM00209 | |
| Domain | TSP1_rpt | 4.56e-04 | 65 | 103 | 4 | IPR000884 | |
| Domain | TSP1 | 4.56e-04 | 65 | 103 | 4 | PS50092 | |
| Domain | Rab_bind | 6.21e-04 | 7 | 103 | 2 | PF16704 | |
| Domain | GCC2_Rab_bind | 6.21e-04 | 7 | 103 | 2 | IPR032023 | |
| Domain | Leu-rich_rpt_4 | 1.32e-03 | 10 | 103 | 2 | IPR025875 | |
| Domain | LRR_4 | 1.32e-03 | 10 | 103 | 2 | PF12799 | |
| Domain | - | 1.32e-03 | 10 | 103 | 2 | 1.10.220.60 | |
| Domain | Grip | 1.60e-03 | 11 | 103 | 2 | SM00755 | |
| Domain | GRIP | 1.60e-03 | 11 | 103 | 2 | PF01465 | |
| Domain | Ran_BP1 | 1.92e-03 | 12 | 103 | 2 | PF00638 | |
| Domain | RANBD1 | 1.92e-03 | 12 | 103 | 2 | PS50196 | |
| Domain | GRIP_dom | 1.92e-03 | 12 | 103 | 2 | IPR000237 | |
| Domain | GRIP | 1.92e-03 | 12 | 103 | 2 | PS50913 | |
| Domain | RanBD | 2.26e-03 | 13 | 103 | 2 | SM00160 | |
| Domain | Ran_bind_dom | 2.26e-03 | 13 | 103 | 2 | IPR000156 | |
| Domain | IBR | 2.62e-03 | 14 | 103 | 2 | PF01485 | |
| Domain | IBR | 2.62e-03 | 14 | 103 | 2 | SM00647 | |
| Domain | Sushi | 2.96e-03 | 52 | 103 | 3 | PF00084 | |
| Domain | IBR_dom | 3.02e-03 | 15 | 103 | 2 | IPR002867 | |
| Domain | CCP | 3.29e-03 | 54 | 103 | 3 | SM00032 | |
| Domain | WH2 | 3.44e-03 | 16 | 103 | 2 | PF02205 | |
| Domain | SUSHI | 3.65e-03 | 56 | 103 | 3 | PS50923 | |
| Domain | Sushi_SCR_CCP_dom | 3.84e-03 | 57 | 103 | 3 | IPR000436 | |
| Pathway | KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS | 1.03e-05 | 135 | 79 | 7 | M15247 | |
| Pathway | REACTOME_NEGATIVE_REGULATORS_OF_DDX58_IFIH1_SIGNALING | 4.19e-05 | 35 | 79 | 4 | M985 | |
| Pathway | REACTOME_TOLL_LIKE_RECEPTOR_CASCADES | 4.58e-05 | 170 | 79 | 7 | M7494 | |
| Pathway | REACTOME_TOLL_LIKE_RECEPTOR_4_TLR4_CASCADE | 6.16e-05 | 122 | 79 | 6 | MM14640 | |
| Pathway | REACTOME_E3_UBIQUITIN_LIGASES_UBIQUITINATE_TARGET_PROTEINS | 1.14e-04 | 45 | 79 | 4 | MM15508 | |
| Pathway | REACTOME_INACTIVATION_OF_CSF3_G_CSF_SIGNALING | 1.30e-04 | 18 | 79 | 3 | MM15680 | |
| Pathway | REACTOME_TICAM1_RIP1_MEDIATED_IKK_COMPLEX_RECRUITMENT | 1.54e-04 | 19 | 79 | 3 | M27020 | |
| Pathway | REACTOME_TOLL_LIKE_RECEPTOR_CASCADES | 2.30e-04 | 155 | 79 | 6 | MM14665 | |
| Pathway | REACTOME_SIGNALING_BY_CSF3_G_CSF | 2.42e-04 | 22 | 79 | 3 | MM15675 | |
| Pathway | REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 | 2.77e-04 | 23 | 79 | 3 | M1003 | |
| Pathway | REACTOME_E3_UBIQUITIN_LIGASES_UBIQUITINATE_TARGET_PROTEINS | 3.29e-04 | 59 | 79 | 4 | M27763 | |
| Pathway | REACTOME_INACTIVATION_OF_CSF3_G_CSF_SIGNALING | 3.56e-04 | 25 | 79 | 3 | M41829 | |
| Pathway | REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 | 3.56e-04 | 25 | 79 | 3 | MM15646 | |
| Pathway | REACTOME_MYD88_INDEPENDENT_TLR4_CASCADE | 3.61e-04 | 109 | 79 | 5 | M29565 | |
| Pathway | REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM | RAG1 TRIM31 TNFRSF11A ALPK1 ITGAM UBE2D1 UBE2D2 UBE2D3 NLRC5 IRAK3 EIF4G3 MX2 PML | 4.09e-04 | 789 | 79 | 13 | M1060 |
| Pathway | REACTOME_PEROXISOMAL_PROTEIN_IMPORT | 4.23e-04 | 63 | 79 | 4 | M27915 | |
| Pathway | REACTOME_PROTEIN_UBIQUITINATION | 4.77e-04 | 65 | 79 | 4 | MM15490 | |
| Pathway | REACTOME_PEROXISOMAL_PROTEIN_IMPORT | 4.77e-04 | 65 | 79 | 4 | MM15628 | |
| Pathway | REACTOME_CELLULAR_RESPONSE_TO_HYPOXIA | 5.99e-04 | 69 | 79 | 4 | MM14522 | |
| Pathway | REACTOME_SIGNALING_BY_CSF3_G_CSF | 6.17e-04 | 30 | 79 | 3 | M41825 | |
| Pathway | REACTOME_SIGNALING_BY_BMP | 6.80e-04 | 31 | 79 | 3 | M1662 | |
| Pathway | REACTOME_SIGNALING_BY_BMP | 6.80e-04 | 31 | 79 | 3 | MM14789 | |
| Pathway | REACTOME_CELLULAR_RESPONSE_TO_HYPOXIA | 8.21e-04 | 75 | 79 | 4 | M641 | |
| Pathway | REACTOME_PROTEIN_UBIQUITINATION | 9.98e-04 | 79 | 79 | 4 | M27742 | |
| Pathway | REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA | 1.15e-03 | 82 | 79 | 4 | M1002 | |
| Pathway | REACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS | 1.26e-03 | 84 | 79 | 4 | MM14929 | |
| Pathway | PID_ERBB1_INTERNALIZATION_PATHWAY | 1.55e-03 | 41 | 79 | 3 | M214 | |
| Pubmed | A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. | RNF144B ZSWIM2 RNF17 UBE2D1 UBE2D2 UBE2D3 BRCA1 UBE2D4 TRIM56 PML | 2.74e-12 | 118 | 104 | 10 | 19690564 |
| Pubmed | The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor. | 2.62e-09 | 7 | 104 | 4 | 21685362 | |
| Pubmed | 2.62e-09 | 7 | 104 | 4 | 30884854 | ||
| Pubmed | Ube2W conjugates ubiquitin to α-amino groups of protein N-termini. | 5.23e-09 | 8 | 104 | 4 | 23560854 | |
| Pubmed | 5.23e-09 | 8 | 104 | 4 | 29323787 | ||
| Pubmed | 1.56e-08 | 10 | 104 | 4 | 31087003 | ||
| Pubmed | 1.56e-08 | 10 | 104 | 4 | 28757353 | ||
| Pubmed | Functional interactions between ubiquitin E2 enzymes and TRIM proteins. | 1.66e-08 | 27 | 104 | 5 | 21143188 | |
| Pubmed | 2.45e-08 | 11 | 104 | 4 | 19712108 | ||
| Pubmed | Identification of a family of closely related human ubiquitin conjugating enzymes. | 2.60e-08 | 3 | 104 | 3 | 8530467 | |
| Pubmed | The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes. | 3.67e-08 | 12 | 104 | 4 | 24211586 | |
| Pubmed | Ubiquitination of STING at lysine 224 controls IRF3 activation. | 5.28e-08 | 13 | 104 | 4 | 28763789 | |
| Pubmed | 7.38e-08 | 14 | 104 | 4 | 36481767 | ||
| Pubmed | TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing. | 1.04e-07 | 4 | 104 | 3 | 29426904 | |
| Pubmed | Physical and functional interactions between ZIP kinase and UbcH5. | 1.04e-07 | 4 | 104 | 3 | 18515077 | |
| Pubmed | 1.34e-07 | 16 | 104 | 4 | 37225719 | ||
| Pubmed | 1.74e-07 | 17 | 104 | 4 | 33650289 | ||
| Pubmed | 1.74e-07 | 17 | 104 | 4 | 36563856 | ||
| Pubmed | E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1). | 2.59e-07 | 5 | 104 | 3 | 15684077 | |
| Pubmed | Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair. | 2.59e-07 | 5 | 104 | 3 | 26502057 | |
| Pubmed | Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal. | 2.59e-07 | 5 | 104 | 3 | 25327252 | |
| Pubmed | The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase. | 2.59e-07 | 5 | 104 | 3 | 14562029 | |
| Pubmed | 2.59e-07 | 5 | 104 | 3 | 23408431 | ||
| Pubmed | 2.59e-07 | 5 | 104 | 3 | 19741096 | ||
| Pubmed | 2.59e-07 | 5 | 104 | 3 | 8090726 | ||
| Pubmed | Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex. | 2.59e-07 | 5 | 104 | 3 | 12732733 | |
| Pubmed | MEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis. | 2.59e-07 | 5 | 104 | 3 | 16522193 | |
| Pubmed | 2.59e-07 | 5 | 104 | 3 | 16413270 | ||
| Pubmed | 2.59e-07 | 5 | 104 | 3 | 26124138 | ||
| Pubmed | 2.59e-07 | 5 | 104 | 3 | 31929179 | ||
| Pubmed | Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis. | 2.59e-07 | 5 | 104 | 3 | 23509263 | |
| Pubmed | 2.82e-07 | 19 | 104 | 4 | 27425610 | ||
| Pubmed | Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. | 3.45e-07 | 149 | 104 | 7 | 19549727 | |
| Pubmed | c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling. | 4.34e-07 | 21 | 104 | 4 | 21113135 | |
| Pubmed | Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1. | 5.16e-07 | 6 | 104 | 3 | 22124327 | |
| Pubmed | h-Goliath, paralog of GRAIL, is a new E3 ligase protein, expressed in human leukocytes. | 5.16e-07 | 6 | 104 | 3 | 16549277 | |
| Pubmed | The E3 ubiquitin ligase TRIM32 regulates myoblast proliferation by controlling turnover of NDRG2. | 5.16e-07 | 6 | 104 | 3 | 25701873 | |
| Pubmed | 5.16e-07 | 6 | 104 | 3 | 30404641 | ||
| Pubmed | Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination. | 5.16e-07 | 6 | 104 | 3 | 27678051 | |
| Pubmed | Karyopherin alpha 1 is a putative substrate of the RAG1 ubiquitin ligase. | 5.16e-07 | 6 | 104 | 3 | 19118899 | |
| Pubmed | Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo. | 5.16e-07 | 6 | 104 | 3 | 15280377 | |
| Pubmed | Negative regulation of the RLH signaling by the E3 ubiquitin ligase RNF114. | 5.16e-07 | 6 | 104 | 3 | 28625874 | |
| Pubmed | 5.16e-07 | 6 | 104 | 3 | 33962630 | ||
| Pubmed | The MALDI-TOF E2/E3 Ligase Assay as Universal Tool for Drug Discovery in the Ubiquitin Pathway. | 6.39e-07 | 23 | 104 | 4 | 30017913 | |
| Pubmed | 7.66e-07 | 24 | 104 | 4 | 24647965 | ||
| Pubmed | Reconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes. | 7.66e-07 | 24 | 104 | 4 | 34195792 | |
| Pubmed | 7.83e-07 | 105 | 104 | 6 | 22493164 | ||
| Pubmed | A ubiquitin ligase complex assembles linear polyubiquitin chains. | 9.01e-07 | 7 | 104 | 3 | 17006537 | |
| Pubmed | 9.01e-07 | 7 | 104 | 3 | 24831002 | ||
| Pubmed | 9.01e-07 | 7 | 104 | 3 | 17719635 | ||
| Pubmed | 9.01e-07 | 7 | 104 | 3 | 11714696 | ||
| Pubmed | Control of biochemical reactions through supramolecular RING domain self-assembly. | 9.01e-07 | 7 | 104 | 3 | 12438698 | |
| Pubmed | RNF122: a novel ubiquitin ligase associated with calcium-modulating cyclophilin ligand. | 9.01e-07 | 7 | 104 | 3 | 20553626 | |
| Pubmed | The E3 ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu. | 9.01e-07 | 7 | 104 | 3 | 25278022 | |
| Pubmed | Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate. | 9.01e-07 | 7 | 104 | 3 | 20347421 | |
| Pubmed | 9.01e-07 | 7 | 104 | 3 | 20051513 | ||
| Pubmed | Measuring rates of ubiquitin chain formation as a functional readout of ligase activity. | 9.01e-07 | 7 | 104 | 3 | 22350887 | |
| Pubmed | 9.01e-07 | 7 | 104 | 3 | 34057440 | ||
| Pubmed | 9.01e-07 | 7 | 104 | 3 | 33282879 | ||
| Pubmed | System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes. | 1.07e-06 | 26 | 104 | 4 | 26949039 | |
| Pubmed | The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. | 1.07e-06 | 26 | 104 | 4 | 20061386 | |
| Pubmed | Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay. | 1.26e-06 | 27 | 104 | 4 | 30097011 | |
| Pubmed | Structure and catalytic activation of the TRIM23 RING E3 ubiquitin ligase. | 1.44e-06 | 8 | 104 | 3 | 28681414 | |
| Pubmed | 1.44e-06 | 8 | 104 | 3 | 28972136 | ||
| Pubmed | 1.44e-06 | 8 | 104 | 3 | 18838541 | ||
| Pubmed | 1.44e-06 | 8 | 104 | 3 | 25207814 | ||
| Pubmed | A novel route for F-box protein-mediated ubiquitination links CHIP to glycoprotein quality control. | 1.44e-06 | 8 | 104 | 3 | 16682404 | |
| Pubmed | 1.44e-06 | 8 | 104 | 3 | 12670957 | ||
| Pubmed | Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53. | 1.44e-06 | 8 | 104 | 3 | 15247280 | |
| Pubmed | 1.44e-06 | 8 | 104 | 3 | 14671314 | ||
| Pubmed | K63-linked ubiquitination of DYRK1A by TRAF2 alleviates Sprouty 2-mediated degradation of EGFR. | 1.44e-06 | 8 | 104 | 3 | 34117217 | |
| Pubmed | Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation. | 1.44e-06 | 8 | 104 | 3 | 14661060 | |
| Pubmed | 2.15e-06 | 9 | 104 | 3 | 26711259 | ||
| Pubmed | Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO. | 2.15e-06 | 9 | 104 | 3 | 12525502 | |
| Pubmed | Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125. | 2.15e-06 | 9 | 104 | 3 | 17460044 | |
| Pubmed | Comparison of Cross-Regulation by Different OTUB1:E2 Complexes. | 2.15e-06 | 9 | 104 | 3 | 32049508 | |
| Pubmed | TRAF-interacting protein (TRIP) is a RING-dependent ubiquitin ligase. | 2.15e-06 | 9 | 104 | 3 | 17544371 | |
| Pubmed | 3.07e-06 | 10 | 104 | 3 | 37345264 | ||
| Pubmed | Bag1 directly routes immature BCR-ABL for proteasomal degradation. | 3.07e-06 | 10 | 104 | 3 | 20675402 | |
| Pubmed | E2 conjugating enzyme selectivity and requirements for function of the E3 ubiquitin ligase CHIP. | 3.07e-06 | 10 | 104 | 3 | 21518764 | |
| Pubmed | A dimer-monomer switch controls CHIP-dependent substrate ubiquitylation and processing. | 4.21e-06 | 11 | 104 | 3 | 36027913 | |
| Pubmed | 4.21e-06 | 11 | 104 | 3 | 24438103 | ||
| Pubmed | 4.21e-06 | 11 | 104 | 3 | 22334663 | ||
| Pubmed | 5.15e-06 | 38 | 104 | 4 | 35331737 | ||
| Pubmed | 5.60e-06 | 12 | 104 | 3 | 24905733 | ||
| Pubmed | E1-E2 interactions in ubiquitin and Nedd8 ligation pathways. | 5.60e-06 | 12 | 104 | 3 | 22069333 | |
| Pubmed | PHLDA1 RBBP6 RSF1 BRWD3 SIRT1 PWWP2B HMCN2 BRCA1 UBR5 TRIM56 CDA WDFY3 PML ZNF646 | 6.13e-06 | 1116 | 104 | 14 | 31753913 | |
| Pubmed | Systematic identification of factors for provirus silencing in embryonic stem cells. | 6.99e-06 | 153 | 104 | 6 | 26365490 | |
| Pubmed | 7.27e-06 | 13 | 104 | 3 | 31120930 | ||
| Pubmed | 7.27e-06 | 13 | 104 | 3 | 36576150 | ||
| Pubmed | Arkadia, a novel SUMO-targeted ubiquitin ligase involved in PML degradation. | 7.27e-06 | 13 | 104 | 3 | 23530056 | |
| Pubmed | 8.86e-06 | 2 | 104 | 2 | 26912277 | ||
| Pubmed | A novel crosstalk between BRCA1 and sirtuin 1 in ovarian cancer. | 8.86e-06 | 2 | 104 | 2 | 25323003 | |
| Pubmed | 8.86e-06 | 2 | 104 | 2 | 19088202 | ||
| Pubmed | Structure of the HECT C-lobe of the UBR5 E3 ubiquitin ligase. | 8.86e-06 | 2 | 104 | 2 | 23027739 | |
| Pubmed | A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites. | 8.86e-06 | 2 | 104 | 2 | 16628214 | |
| Pubmed | 8.86e-06 | 2 | 104 | 2 | 21531767 | ||
| Pubmed | BRCA1 deficiency in mature CD8+ T lymphocytes impairs antitumor immunity. | 8.86e-06 | 2 | 104 | 2 | 36731891 | |
| Pubmed | TRIM31 promotes Atg5/Atg7-independent autophagy in intestinal cells. | 8.86e-06 | 2 | 104 | 2 | 27216961 | |
| Pubmed | 9.23e-06 | 14 | 104 | 3 | 14690596 | ||
| Interaction | RNF216 interactions | 7.15e-09 | 52 | 101 | 7 | int:RNF216 | |
| Interaction | ARK2C interactions | 2.85e-07 | 12 | 101 | 4 | int:ARK2C | |
| Interaction | CHFR interactions | 5.48e-07 | 60 | 101 | 6 | int:CHFR | |
| Interaction | TRIM45 interactions | 6.07e-07 | 33 | 101 | 5 | int:TRIM45 | |
| Interaction | UVSSA interactions | 1.10e-06 | 37 | 101 | 5 | int:UVSSA | |
| Interaction | RNF150 interactions | 2.71e-06 | 20 | 101 | 4 | int:RNF150 | |
| Interaction | TRAF6 interactions | CALCOCO2 LIMD1 PHLDA1 TRIM31 TNFRSF11A KMT2E UBE2D1 UBE2D2 UBE2D3 UBE2D4 IRAK3 WDFY3 | 3.68e-06 | 465 | 101 | 12 | int:TRAF6 |
| Interaction | UBOX5 interactions | 4.89e-06 | 23 | 101 | 4 | int:UBOX5 | |
| Interaction | RNF125 interactions | 6.78e-06 | 53 | 101 | 5 | int:RNF125 | |
| Interaction | TOPORS interactions | 8.78e-06 | 96 | 101 | 6 | int:TOPORS | |
| Interaction | RNF34 interactions | 8.92e-06 | 56 | 101 | 5 | int:RNF34 | |
| Interaction | RNF38 interactions | 1.25e-05 | 102 | 101 | 6 | int:RNF38 | |
| Interaction | RNF103 interactions | 1.28e-05 | 29 | 101 | 4 | int:RNF103 | |
| Interaction | CADPS2 interactions | 1.47e-05 | 30 | 101 | 4 | int:CADPS2 | |
| Interaction | RNF181 interactions | 1.60e-05 | 160 | 101 | 7 | int:RNF181 | |
| Interaction | TRIM62 interactions | 1.92e-05 | 32 | 101 | 4 | int:TRIM62 | |
| Interaction | BIRC8 interactions | 1.92e-05 | 32 | 101 | 4 | int:BIRC8 | |
| Interaction | DTX3L interactions | 2.32e-05 | 68 | 101 | 5 | int:DTX3L | |
| Interaction | TRIM17 interactions | 2.46e-05 | 34 | 101 | 4 | int:TRIM17 | |
| Interaction | DTX1 interactions | 2.76e-05 | 35 | 101 | 4 | int:DTX1 | |
| Interaction | ZNRF1 interactions | 3.09e-05 | 36 | 101 | 4 | int:ZNRF1 | |
| Interaction | DZIP3 interactions | 3.80e-05 | 183 | 101 | 7 | int:DZIP3 | |
| Interaction | UBTD1 interactions | 4.73e-05 | 40 | 101 | 4 | int:UBTD1 | |
| Interaction | RFWD3 interactions | 5.11e-05 | 80 | 101 | 5 | int:RFWD3 | |
| Interaction | RNF25 interactions | 6.31e-05 | 43 | 101 | 4 | int:RNF25 | |
| Interaction | RNF122 interactions | 6.53e-05 | 16 | 101 | 3 | int:RNF122 | |
| Interaction | UBE2U interactions | 7.15e-05 | 139 | 101 | 6 | int:UBE2U | |
| Interaction | RNF10 interactions | 7.64e-05 | 87 | 101 | 5 | int:RNF10 | |
| Interaction | UHRF1 interactions | 8.54e-05 | 208 | 101 | 7 | int:UHRF1 | |
| Interaction | UBE2D3 interactions | 8.95e-05 | 283 | 101 | 8 | int:UBE2D3 | |
| Interaction | TRIM38 interactions | 8.98e-05 | 47 | 101 | 4 | int:TRIM38 | |
| Interaction | ZNRF2 interactions | 8.98e-05 | 47 | 101 | 4 | int:ZNRF2 | |
| Interaction | RNF114 interactions | 9.46e-05 | 91 | 101 | 5 | int:RNF114 | |
| Interaction | TRIM10 interactions | 9.76e-05 | 48 | 101 | 4 | int:TRIM10 | |
| Interaction | BFAR interactions | 9.76e-05 | 48 | 101 | 4 | int:BFAR | |
| Interaction | TRIM50 interactions | 1.06e-04 | 49 | 101 | 4 | int:TRIM50 | |
| Interaction | RNF14 interactions | 1.06e-04 | 49 | 101 | 4 | int:RNF14 | |
| Interaction | RNF111 interactions | 1.28e-04 | 97 | 101 | 5 | int:RNF111 | |
| Interaction | RNF168 interactions | 1.34e-04 | 98 | 101 | 5 | int:RNF168 | |
| Interaction | DCAF1 interactions | 1.35e-04 | 224 | 101 | 7 | int:DCAF1 | |
| Interaction | TRIM43 interactions | 1.44e-04 | 53 | 101 | 4 | int:TRIM43 | |
| Interaction | TRIM2 interactions | 1.44e-04 | 53 | 101 | 4 | int:TRIM2 | |
| Interaction | TRIM8 interactions | 1.48e-04 | 100 | 101 | 5 | int:TRIM8 | |
| Interaction | RNF167 interactions | 1.55e-04 | 54 | 101 | 4 | int:RNF167 | |
| Interaction | MAP3K1 interactions | 1.61e-04 | 161 | 101 | 6 | int:MAP3K1 | |
| Interaction | TRIM35 interactions | 1.70e-04 | 103 | 101 | 5 | int:TRIM35 | |
| Interaction | MYLIP interactions | 1.79e-04 | 56 | 101 | 4 | int:MYLIP | |
| Interaction | UBE2D2 interactions | 1.99e-04 | 318 | 101 | 8 | int:UBE2D2 | |
| Interaction | RNF11 interactions | 2.09e-04 | 169 | 101 | 6 | int:RNF11 | |
| Interaction | TRIM39 interactions | 2.12e-04 | 108 | 101 | 5 | int:TRIM39 | |
| Interaction | ZNRF4 interactions | 2.31e-04 | 110 | 101 | 5 | int:ZNRF4 | |
| Interaction | RNF26 interactions | 2.34e-04 | 60 | 101 | 4 | int:RNF26 | |
| Interaction | RNF13 interactions | 2.34e-04 | 60 | 101 | 4 | int:RNF13 | |
| Interaction | COP1 interactions | 2.36e-04 | 326 | 101 | 8 | int:COP1 | |
| Interaction | RBCK1 interactions | 2.60e-04 | 176 | 101 | 6 | int:RBCK1 | |
| Interaction | POLM interactions | 2.92e-04 | 26 | 101 | 3 | int:POLM | |
| Interaction | UFM1 interactions | 3.08e-04 | 117 | 101 | 5 | int:UFM1 | |
| Interaction | CNOT4 interactions | 3.18e-04 | 65 | 101 | 4 | int:CNOT4 | |
| Interaction | AREL1 interactions | 3.27e-04 | 27 | 101 | 3 | int:AREL1 | |
| Interaction | MCM10 interactions | 4.02e-04 | 124 | 101 | 5 | int:MCM10 | |
| Interaction | MYL12A interactions | 4.14e-04 | 192 | 101 | 6 | int:MYL12A | |
| Interaction | TRIM32 interactions | 4.26e-04 | 193 | 101 | 6 | int:TRIM32 | |
| Interaction | RING1 interactions | 5.27e-04 | 201 | 101 | 6 | int:RING1 | |
| Interaction | EEF1G interactions | 5.32e-04 | 463 | 101 | 9 | int:EEF1G | |
| Interaction | CBLC interactions | 5.50e-04 | 75 | 101 | 4 | int:CBLC | |
| Cytoband | 5q11.1 | 1.41e-04 | 8 | 104 | 2 | 5q11.1 | |
| GeneFamily | Ring finger proteins | 1.59e-06 | 275 | 73 | 9 | 58 | |
| GeneFamily | Ubiquitin conjugating enzymes E2 | 2.21e-05 | 41 | 73 | 4 | 102 | |
| GeneFamily | PWWP domain containing | 9.20e-05 | 22 | 73 | 3 | 1147 | |
| GeneFamily | Hyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing | 1.58e-03 | 57 | 73 | 3 | 1179 | |
| Coexpression | GSE21546_WT_VS_SAP1A_KO_DP_THYMOCYTES_UP | 1.31e-05 | 197 | 103 | 7 | M7543 | |
| Coexpression | GSE20727_CTRL_VS_H2O2_TREATED_DC_UP | 1.36e-05 | 198 | 103 | 7 | M9245 | |
| Coexpression | GSE11961_FOLLICULAR_BCELL_VS_GERMINAL_CENTER_BCELL_DAY7_DN | 1.45e-05 | 200 | 103 | 7 | M9341 | |
| ToppCell | mild-Neutrophil|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class | 4.40e-07 | 199 | 104 | 7 | ca319976a7d2576186d0a98cdc93e4c2d5fe8a05 | |
| ToppCell | droplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_28|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype | 3.29e-06 | 173 | 104 | 6 | 66488d01e03264fb193285470901c9c4182fbae8 | |
| ToppCell | Calu_3-infected-SARSCoV2|infected / Cell line, Condition and Strain | 5.81e-06 | 191 | 104 | 6 | 2da876d26f37a00dbdf1ee79d724306e8b20f304 | |
| ToppCell | Smart-seq2-bone_marrow_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type | 5.81e-06 | 191 | 104 | 6 | d4f77c73311d1149466bbfe4adbd6a301946ec90 | |
| ToppCell | 10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_naive-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group | 5.81e-06 | 191 | 104 | 6 | 63d4226a8b59f648bdc9f41e4b2d750dfa342034 | |
| ToppCell | Control-Myeloid-cMonocyte|Control / Disease state, Lineage and Cell class | 5.99e-06 | 192 | 104 | 6 | ad04c9c4bdebf94615cee1904ca48197e62c923b | |
| ToppCell | Smart-seq2-bone_marrow_(Smart-seq2)-myeloid-myeloid_granulocytic|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type | 6.17e-06 | 193 | 104 | 6 | e1855cff9a6bcfda9188b9fdf6c9d698405da990 | |
| ToppCell | 3'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5 | 7.14e-06 | 198 | 104 | 6 | c288b29287a562460d8970264e1833801590da73 | |
| ToppCell | 10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_granulocytic|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type | 7.35e-06 | 199 | 104 | 6 | b7af2b4fe6866cc8c78cf0f78390aab1b1b389ba | |
| ToppCell | TCGA-Bile_Duct-Primary_Tumor-Cholangiocarcinoma|TCGA-Bile_Duct / Sample_Type by Project: Shred V9 | 7.56e-06 | 200 | 104 | 6 | ad2a6da0b1ae7a9212a3c91e5eec4baa7481d8dc | |
| ToppCell | TCGA-Bile_Duct-Primary_Tumor|TCGA-Bile_Duct / Sample_Type by Project: Shred V9 | 7.56e-06 | 200 | 104 | 6 | 0350e5ffd36033099b7e32a1fdd790fff99790dc | |
| ToppCell | 10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_granulocytic-neutrophil|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type | 7.56e-06 | 200 | 104 | 6 | 808571d74bb5c4d765ff13fc9393f88020d4e90d | |
| ToppCell | droplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation | 4.04e-05 | 163 | 104 | 5 | 8dc0128eeede933537e3bcc5d6ec0322711552f3 | |
| ToppCell | droplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation | 4.04e-05 | 163 | 104 | 5 | fd243ca223079033be480a24817a399f281fa4d4 | |
| ToppCell | droplet-Kidney-KIDNEY-1m-Myeloid-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation | 5.08e-05 | 171 | 104 | 5 | d9ad6a3bce3556abd24af1630bf4a99594437c3a | |
| ToppCell | droplet-Mammary_Gland-nan-21m-Endothelial-basal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation | 5.82e-05 | 176 | 104 | 5 | 27e5115fae5f0f63b333bc99fbf6a6d4c9182c46 | |
| ToppCell | 10x5'-bone_marrow-Mast-Mast_cell_lympho|bone_marrow / Manually curated celltypes from each tissue | 6.64e-05 | 181 | 104 | 5 | 56fa77ae31f3b7de6e441a439c33a11353b6573a | |
| ToppCell | 5'-Adult-LymphNode-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract | 6.64e-05 | 181 | 104 | 5 | ab66a89f316b935d9ba1277426d976b1e9e39757 | |
| ToppCell | Calu_3-infected|Calu_3 / Cell line, Condition and Strain | 7.00e-05 | 183 | 104 | 5 | 8f7f5000645f24f20a8d7700c4df1f8953a1780b | |
| ToppCell | 3'_v3-blood|World / Manually curated celltypes from each tissue | 7.75e-05 | 187 | 104 | 5 | 9e70e8d7cd8ae517ddf5fd56c69ec16fc33ddff5 | |
| ToppCell | 10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_naive-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group | 8.15e-05 | 189 | 104 | 5 | 55aba1ebc012006a5db3ff9c92589cb3d9f7c68a | |
| ToppCell | COPD-Myeloid-ncMonocyte|World / Disease state, Lineage and Cell class | 8.35e-05 | 190 | 104 | 5 | aece860b5609ad5a8fc920d685f0d0ec71bf9018 | |
| ToppCell | COPD-Myeloid-ncMonocyte|Myeloid / Disease state, Lineage and Cell class | 8.35e-05 | 190 | 104 | 5 | ed978cd5d9da87b49878a330e362762c487f849f | |
| ToppCell | IPF-Myeloid-cMonocyte|World / Disease state, Lineage and Cell class | 8.35e-05 | 190 | 104 | 5 | ffa890138394f579fee53fcfac6c121bf86adc26 | |
| ToppCell | PCW_13-14|World / Celltypes from embryonic and fetal-stage human lung | 8.35e-05 | 190 | 104 | 5 | 62a3ec1ae0829602b0569cc051210551644f1d46 | |
| ToppCell | IPF-Myeloid-cMonocyte|IPF / Disease state, Lineage and Cell class | 8.35e-05 | 190 | 104 | 5 | a099f51f2b7618b6712af38eedd5ee64d8663a4a | |
| ToppCell | IPF-Myeloid-ncMonocyte|World / Disease state, Lineage and Cell class | 8.35e-05 | 190 | 104 | 5 | f9c2a13c7f6460e3b348581be855b7281c8f70b5 | |
| ToppCell | IPF-Myeloid-ncMonocyte|IPF / Disease state, Lineage and Cell class | 8.77e-05 | 192 | 104 | 5 | e9fb8c57d8094f70fb492909b2bec40aa5f2e5b8 | |
| ToppCell | TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9 | 8.99e-05 | 193 | 104 | 5 | abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659 | |
| ToppCell | COPD-Myeloid-ncMonocyte|COPD / Disease state, Lineage and Cell class | 8.99e-05 | 193 | 104 | 5 | 936ca95995599356b794fba32bfd82d8de339365 | |
| ToppCell | 10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group | 8.99e-05 | 193 | 104 | 5 | b93f6af5999ad207fef5edc2bd900c7c6342f626 | |
| ToppCell | 3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5 | 8.99e-05 | 193 | 104 | 5 | bdb7401dd9059032f930f2b575f2ef8e504b6594 | |
| ToppCell | LA-14._Fibroblast_III|World / Chamber and Cluster_Paper | 9.21e-05 | 194 | 104 | 5 | 803fa83ceada17c38ca9f933b888f7e7b0b90761 | |
| ToppCell | 10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_monocytic-classical_monocyte|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type | 9.44e-05 | 195 | 104 | 5 | 580ed65b4152483b642a7e7dbdf00d03588c46f6 | |
| ToppCell | Control-Myeloid-ncMonocyte|Control / Disease state, Lineage and Cell class | 9.44e-05 | 195 | 104 | 5 | fcb05948e7480dc53f06f3fc9b9c3fc129874edd | |
| ToppCell | BL-critical-LOC-Myeloid-Neutrophil|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined) | 9.67e-05 | 196 | 104 | 5 | f64d7fed31e418c55fe946744d78c3cbecec9bbf | |
| ToppCell | 3'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5 | 9.67e-05 | 196 | 104 | 5 | 555c9e443fe3b9893cb320b78d84002e1f8c1701 | |
| ToppCell | 10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_monocytic|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type | 9.67e-05 | 196 | 104 | 5 | f943519bff51c3094776fd45889dadf9062c8379 | |
| ToppCell | Mild-CD8+_T_activated|World / Disease group and Cell class | 9.67e-05 | 196 | 104 | 5 | 79632190e44fcef9d7c11d9b9e37f2ebf0e6e255 | |
| ToppCell | 3'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5 | 9.67e-05 | 196 | 104 | 5 | a1b21f4667c05e837a1229cc5934db805ad562c5 | |
| ToppCell | BL-critical-LOC-Myeloid|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined) | 9.90e-05 | 197 | 104 | 5 | 932a7fae4979b561688e6222505df0f4e510ab11 | |
| ToppCell | severe_COVID-19-Classical_Monocyte|World / disease group, cell group and cell class (v2) | 9.90e-05 | 197 | 104 | 5 | cdffd49db7374d223ded46d636cd4be12d464ea4 | |
| ToppCell | Influenza_Severe-Classical_Monocyte|World / Disease group and Cell class | 9.90e-05 | 197 | 104 | 5 | e9a01f0fbbeaf6b23bce4603f62053c003848da4 | |
| ToppCell | 10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_naive-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group | 9.90e-05 | 197 | 104 | 5 | f4b82cd035c2d362ae81dd555432410316721364 | |
| ToppCell | Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_naive|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group | 9.90e-05 | 197 | 104 | 5 | 4d3670456655248250d156f92de01df4aa481733 | |
| ToppCell | 3'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5 | 9.90e-05 | 197 | 104 | 5 | f431f11196dc4332933b5d71c7c7408d54c2dedc | |
| ToppCell | PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung | 9.90e-05 | 197 | 104 | 5 | 0034bae02ee7fcfea520d453ca3c842ab6963b12 | |
| ToppCell | COVID-19_Severe-Classical_Monocyte|World / disease group, cell group and cell class | 9.90e-05 | 197 | 104 | 5 | 344801997b89bd81d8d5c3c872934de523233a8d | |
| ToppCell | myeloid-Monocyte-CD14+_Monocyte|World / Lineage, cell class and subclass | 1.01e-04 | 198 | 104 | 5 | 2528062d1646746b2e7d6b0ec38f8cfabf3df18f | |
| ToppCell | COVID-19-lung-Macrophage_VCANhi_FCN1hi|COVID-19 / Disease (COVID-19 only), tissue and cell type | 1.01e-04 | 198 | 104 | 5 | ea34096bee852a7e996f097fa279381afa8f86ff | |
| ToppCell | PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k) | 1.01e-04 | 198 | 104 | 5 | 110f7ebb3e1ec19508d4d2b973e1f64e7bdbb5b5 | |
| ToppCell | 10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_hypoxia|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group | 1.01e-04 | 198 | 104 | 5 | dc59442e6a5127d3071a036c206732a21e456a17 | |
| ToppCell | PBMC-Severe-Myeloid|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01) | 1.01e-04 | 198 | 104 | 5 | a8338da2477ccf8e3d924de8dbe1056b98111532 | |
| ToppCell | myeloid|World / Lineage, cell class and subclass | 1.01e-04 | 198 | 104 | 5 | 67334ca0ec4a5070d8ddaecffb84e7437bf77765 | |
| ToppCell | severe_COVID-19-Classical_Monocyte|severe_COVID-19 / disease group, cell group and cell class (v2) | 1.01e-04 | 198 | 104 | 5 | 40dd3333945aa0c9120296b75155c621f462dbe8 | |
| ToppCell | 3'_v3-lymph-node_spleen-Myeloid_Monocytic-Classical_monocytes|lymph-node_spleen / Manually curated celltypes from each tissue | 1.01e-04 | 198 | 104 | 5 | 187a04d498f0b355cb11c81172721698818082d6 | |
| ToppCell | PBMC-Severe-Myeloid|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09) | 1.01e-04 | 198 | 104 | 5 | 603846129560d5d6e6df27d6168f67f592e5e6e2 | |
| ToppCell | PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Monocytic|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k) | 1.01e-04 | 198 | 104 | 5 | b19a089eb80af3428891f2ff00e53a6e11894fa3 | |
| ToppCell | 3'_v3-lymph-node_spleen-Myeloid_Monocytic|lymph-node_spleen / Manually curated celltypes from each tissue | 1.01e-04 | 198 | 104 | 5 | 065c8a9655d19f93dfdb453c78bbfe7d857caf3e | |
| ToppCell | mild-HLA-DR-_S100A+_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class | 1.04e-04 | 199 | 104 | 5 | d0d286eafe935f9b3aaba5b783e8911251121b4a | |
| ToppCell | (02)_MMP9/10+-(2)_GFP_FOXI1|(02)_MMP9/10+ / shred by cell type by condition | 1.04e-04 | 199 | 104 | 5 | 18a7f9ced4364f45b184bd529f32ef02c27779d3 | |
| ToppCell | Tracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations | 1.04e-04 | 199 | 104 | 5 | 94b94b17ca18b8dc27b91da1f2ccf89e03cc7035 | |
| ToppCell | Fetal_brain-organoid_Tanaka_cellReport-GW13-Stem_cells|GW13 / Sample Type, Dataset, Time_group, and Cell type. | 1.06e-04 | 200 | 104 | 5 | d933978b55fefe52cad599b36f6b47a0c7f71f96 | |
| ToppCell | MS-IIF-Myeloid-CD14+_Monocyte|IIF / Disease, condition lineage and cell class | 1.06e-04 | 200 | 104 | 5 | 50d874971dabd3a3b26cc859d1977ffd01fad172 | |
| ToppCell | 10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_granulocytic-neutrophil|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type | 1.06e-04 | 200 | 104 | 5 | 6beabd5bad042d4d65c89c2f537c7376230f7c08 | |
| ToppCell | Fetal_brain-organoid_Tanaka_cellReport-GW13-Stem_cells-Neuroepithelial_cell|GW13 / Sample Type, Dataset, Time_group, and Cell type. | 1.06e-04 | 200 | 104 | 5 | 3d932765c31aef1f80a118d51e8e66c50a758dbb | |
| ToppCell | COVID-19-COVID-19_Severe-Myeloid|COVID-19_Severe / Disease, condition lineage and cell class | 1.06e-04 | 200 | 104 | 5 | 1315bc0582b19c2fed91c740a1a7e9285c700df1 | |
| ToppCell | severe-Classical_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class | 1.06e-04 | 200 | 104 | 5 | f46689940fdea500ce2457eec412dd2c46705819 | |
| ToppCell | 10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_granulocytic|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type | 1.06e-04 | 200 | 104 | 5 | 026495aa7f1e7528a01d9199475cfc393677fc60 | |
| ToppCell | (05)_Ciliated-(3)_72hpi|(05)_Ciliated / shred by cell type and Timepoint | 1.43e-04 | 113 | 104 | 4 | eaa5bc8f8183b353ee1e7618e99220eb3684cd60 | |
| ToppCell | Striatum-Macroglia-CSF_related-EPENDYMAL-Ependyma_Ccdc153.Ccdc153_(Ccdc153)-|Striatum / BrainAtlas - Mouse McCarroll V32 | 1.63e-04 | 117 | 104 | 4 | 26dec09112532f351fb7a2202bae84c365707b40 | |
| ToppCell | Striatum-Macroglia-CSF_related-EPENDYMAL-Ependyma_Ccdc153.Ccdc153_(Ccdc153)|Striatum / BrainAtlas - Mouse McCarroll V32 | 1.63e-04 | 117 | 104 | 4 | db053c874e6739052dff1f91643e51b306236237 | |
| ToppCell | Striatum-Macroglia-CSF_related-EPENDYMAL-Ependyma_Ccdc153.Ccdc153_(Ccdc153)--|Striatum / BrainAtlas - Mouse McCarroll V32 | 1.63e-04 | 117 | 104 | 4 | 80780223502d18f0d86a29ff3cb74aa8235103c7 | |
| ToppCell | Striatum-Macroglia-CSF_related-EPENDYMAL|Striatum / BrainAtlas - Mouse McCarroll V32 | 1.63e-04 | 117 | 104 | 4 | 40889f4a387846abbf54469cc4faf616bfe348d0 | |
| ToppCell | Striatum-Macroglia-CSF_related|Striatum / BrainAtlas - Mouse McCarroll V32 | 1.63e-04 | 117 | 104 | 4 | e12e37e393257db85f7f5c13454095c44f59d374 | |
| Computational | Genes in the cancer module 4. | 3.44e-06 | 21 | 55 | 4 | MODULE_4 | |
| Computational | Genes in the cancer module 233. | 4.19e-06 | 22 | 55 | 4 | MODULE_233 | |
| Computational | Genes in the cancer module 82. | 6.04e-06 | 24 | 55 | 4 | MODULE_82 | |
| Drug | Ambroxol hydrochloride [23828-92-4]; Up 200; 9.6uM; MCF7; HT_HG-U133A | 3.33e-06 | 198 | 103 | 8 | 5319_UP | |
| Disease | Paroxysmal atrial fibrillation | 1.86e-04 | 156 | 99 | 5 | C0235480 | |
| Disease | familial atrial fibrillation | 1.86e-04 | 156 | 99 | 5 | C3468561 | |
| Disease | Persistent atrial fibrillation | 1.86e-04 | 156 | 99 | 5 | C2585653 | |
| Disease | Atrial Fibrillation | 2.09e-04 | 160 | 99 | 5 | C0004238 | |
| Disease | Osteitis Deformans | 3.95e-04 | 9 | 99 | 2 | C0029401 | |
| Disease | MENTAL RETARDATION, AUTOSOMAL DOMINANT 40 | 3.95e-04 | 9 | 99 | 2 | C4225275 | |
| Disease | osteitis deformans | 8.48e-04 | 13 | 99 | 2 | EFO_0004261 | |
| Disease | complement component C6 measurement | 8.48e-04 | 13 | 99 | 2 | EFO_0020281 | |
| Disease | autism spectrum disorder (is_implicated_in) | 1.30e-03 | 16 | 99 | 2 | DOID:0060041 (is_implicated_in) | |
| Disease | stomach cancer (is_marker_for) | 1.36e-03 | 142 | 99 | 4 | DOID:10534 (is_marker_for) | |
| Disease | atrial fibrillation | 1.59e-03 | 371 | 99 | 6 | EFO_0000275 | |
| Disease | visceral:subcutaneous adipose tissue ratio | 1.70e-03 | 70 | 99 | 3 | EFO_0004767 | |
| Disease | autism spectrum disorder (implicated_via_orthology) | 1.74e-03 | 152 | 99 | 4 | DOID:0060041 (implicated_via_orthology) | |
| Disease | osteoporosis (implicated_via_orthology) | 1.84e-03 | 19 | 99 | 2 | DOID:11476 (implicated_via_orthology) |
| Peptide | Gene | Start | Entry |
|---|---|---|---|
| QPFTVACKIDPVLCK | 86 | Q6ZRU5 | |
| PAPQCKALCRKPELV | 476 | P04003 | |
| KELLCQLENPPLSEK | 2871 | Q96N23 | |
| IFLPKKLLECLPKCS | 51 | Q9Y6Y1 | |
| KLLECLPKCSSLPKE | 56 | Q9Y6Y1 | |
| CQLCLLAKCFKPALP | 146 | Q9UNS2 | |
| PRLQPLCVKCLDGKE | 546 | Q96Q42 | |
| SQPLPCERKDVLCGK | 536 | Q9Y3Q7 | |
| IKYEVGPPTLCCLKL | 991 | Q6RI45 | |
| KKAADKNLPCRPLVC | 431 | Q5T2E6 | |
| KNLPCRPLVCAVLDL | 436 | Q5T2E6 | |
| KLVKENKCPCRVEPC | 151 | Q5H913 | |
| CDLKPENILLCNPKR | 286 | Q13627 | |
| LSCLLALLKPCKDFE | 126 | A2RUS2 | |
| VPLLAACLPQDKCKV | 111 | Q8NBA8 | |
| CPQLLRLEEVCLKDP | 246 | Q9P1Y5 | |
| KPKTLLSCNRDILCP | 931 | P58397 | |
| CPPELKNLHLCEAKE | 316 | Q96QP1 | |
| EAKPNSELCCKPLCL | 646 | P15918 | |
| LPQDKALETLLQPCK | 361 | Q6ZP01 | |
| EPVPCLLLANKCDLS | 116 | O14966 | |
| PVTQELICKCVLDPK | 646 | Q14573 | |
| LICKCVLDPKNSDIL | 651 | Q14573 | |
| LECLPVELGECPLLK | 766 | Q8IWT6 | |
| LTRLPCLKDLCLNDP | 186 | Q6ZRR7 | |
| ECPLCREKFPPQKLI | 306 | O60683 | |
| DLAPAPLITCKLCLC | 21 | Q7Z419 | |
| PCPAAVKSEECLTLK | 366 | Q8N3A8 | |
| PKALCFLPKLISLDL | 296 | A4D1F6 | |
| LVPESLCRCPKLRKL | 331 | Q13045 | |
| KVLAPKCAACGLPIL | 591 | Q9UGP4 | |
| VSSCKCKPVPLLELA | 61 | Q8NHV4 | |
| LCPPLLCNQDKETLT | 521 | Q9NVR5 | |
| TCKPLLKCPSLVTLP | 341 | Q86W28 | |
| SLPCLDVNECLQLPK | 4751 | Q8NDA2 | |
| KPIGLCCIAPVLAAK | 171 | A0A0B4J2D5 | |
| ILIIPSLGLIKCCLK | 156 | Q9H2C5 | |
| PSKRCPLKTLQKCEI | 576 | Q96RN5 | |
| CLKENPECPVLKRSS | 461 | Q8IZD2 | |
| CLLLLKSLPPAEAEK | 911 | P50748 | |
| PHCPLCKDKLSELLA | 481 | Q1L5Z9 | |
| LDSCLSFLDKKVPPC | 396 | Q9Y616 | |
| KCLSPDLPLPKQLVC | 156 | Q9BZE0 | |
| LCDIKPLLKLACGNT | 176 | P58182 | |
| LKDCPGPLELQLSCE | 1131 | Q86WI3 | |
| DPIPDELLCLICKDI | 251 | Q7Z6E9 | |
| LCETPKISGKKCLPR | 141 | Q4G163 | |
| LPLPVCKQLCTERQK | 516 | A6NKT7 | |
| ILECPICLELIKEPV | 21 | P38398 | |
| KQELPELKSCLCPTV | 631 | Q9NPB8 | |
| KACCVPTKLEPISIL | 386 | O95393 | |
| LVAFQPCIPSKLCKI | 121 | P13671 | |
| DVRKVCQDCPLLAPL | 141 | P02765 | |
| LLKLYVKPCCPDIDI | 196 | Q5XKL5 | |
| PLQNILPVICAKCEV | 176 | O75128 | |
| KLDLPCELQFPQCLL | 331 | Q9NSG2 | |
| PLSIKKCPICKADDI | 391 | Q13137 | |
| KCGLECPLILPKVFN | 61 | Q9P267 | |
| KPIGLCCIAPVLAAK | 171 | P0DPI2 | |
| SKQLPPCNLSKEDLL | 21 | Q9H6D7 | |
| TLKDPVIKRCCEAPN | 1521 | Q8IVF4 | |
| VLCEKCKSTLSPPEA | 176 | Q6NUJ5 | |
| PPCQHKLLCEKLEEQ | 936 | Q96T23 | |
| CKKPCSVAPNDIPLV | 336 | O43432 | |
| LCDPAPLLTLTCKKG | 216 | Q8NGC1 | |
| ATRCLPCPDSQKLEK | 356 | Q2TAK8 | |
| IIDELPPCKKKAVLC | 186 | Q16563 | |
| LPLPVCKQLCTERQK | 516 | Q7Z3J3 | |
| CPICLDILQKPVTID | 16 | Q9BZY9 | |
| VIELCCPPDPAKKLL | 461 | Q96GJ1 | |
| AKSLCIPFKPLCELQ | 1476 | P07814 | |
| KPTAKSLPCDVCQDI | 56 | Q6NUJ1 | |
| VRPCLLPCKKDCIVT | 761 | Q9UPZ6 | |
| PKDKLISLCQCDPIL | 426 | P48378 | |
| QAEAKCPKLLPCLHT | 61 | P29590 | |
| DPALLEFLVCPLSKK | 51 | Q96I23 | |
| NGCLKCSPKLFILLE | 51 | Q2MKA7 | |
| CCNPVKLSEITEKPP | 501 | Q96EB6 | |
| DPPKKKRLISLCVGC | 6 | P61371 | |
| CETLKLQLPNCIEDP | 711 | P11215 | |
| PTCKAIECLKPKEIL | 2491 | Q4LDE5 | |
| CTPKDPICIAELQLL | 46 | Q14865 | |
| PACTLKPECVQQLLV | 6 | P32320 | |
| LKDIQPLAQPCSLKD | 566 | Q9BXT8 | |
| IDKPKCLQDEECPLV | 211 | Q8IUA0 | |
| PQKIAAKCGLILACP | 21 | Q6UXU6 | |
| VKPFDPKITCKQECL | 351 | P17752 | |
| KVLLSICSLLCDPNP | 101 | P62837 | |
| QILCAICPNPKLVIT | 3081 | Q8IZQ1 | |
| CCILTEEGLLLIPPK | 171 | Q8WV24 | |
| CLASCPLLKIEDVLP | 776 | Q9P253 | |
| CSLCPKLLPNLLSLK | 1706 | O15015 | |
| KVLLSICSLLCDPNP | 101 | P61077 | |
| DKDFQCLIKLLPSCL | 191 | Q7Z7A4 | |
| SCSVPKLPKKCLALA | 126 | Q8TCU3 | |
| KCKELPQAVCEILGL | 616 | Q8TC07 | |
| KELVCAGECLPLPVL | 96 | Q6X4U4 | |
| ICSICQELLLEKKLP | 146 | Q8NEG5 | |
| EKPPACLLCGKAFSL | 281 | P0CI00 | |
| SKPCILATLLDPCFK | 761 | P86452 | |
| KVLLSICSLLCDPNP | 101 | Q9Y2X8 | |
| SLKCPFDLLIPKNNC | 101 | Q86T29 | |
| LLQCLPDEKCLPKDI | 981 | O95405 | |
| CKICLEQLRAPKTLP | 21 | Q9BRZ2 | |
| KVPDCFQRTPKKLCI | 726 | O95071 | |
| HPLQLNKDTVCKPCL | 141 | Q9Y6Q6 | |
| KVLLSICSLLCDPNP | 101 | P51668 | |
| FAKLPCVLPLKCSLD | 2181 | Q9P2D8 | |
| ELQPKKLHLCPLCGK | 371 | O14978 | |
| TRCPLVLKLKKQPCE | 151 | P20592 |