Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	ureteric bud development	LHX1 CTNNBIP1 SIM1 SDC1 FOXC1 SMAD5	6.94e-06	107	89	6	GO:0001657
GeneOntologyBiologicalProcess	mesonephric tubule development	LHX1 CTNNBIP1 SIM1 SDC1 FOXC1 SMAD5	8.13e-06	110	89	6	GO:0072164
GeneOntologyBiologicalProcess	mesonephric epithelium development	LHX1 CTNNBIP1 SIM1 SDC1 FOXC1 SMAD5	8.13e-06	110	89	6	GO:0072163
GeneOntologyBiologicalProcess	mesonephros development	LHX1 CTNNBIP1 SIM1 SDC1 FOXC1 SMAD5	9.50e-06	113	89	6	GO:0001823
GeneOntologyBiologicalProcess	kidney development	LHX1 CTNNBIP1 ROBO1 PLXND1 SIM1 SDC1 FOXC1 SMAD5 PCNT	3.27e-05	372	89	9	GO:0001822
GeneOntologyBiologicalProcess	renal system development	LHX1 CTNNBIP1 ROBO1 PLXND1 SIM1 SDC1 FOXC1 SMAD5 PCNT	4.36e-05	386	89	9	GO:0072001
GeneOntologyBiologicalProcess	kidney epithelium development	LHX1 CTNNBIP1 SIM1 SDC1 FOXC1 SMAD5	7.26e-05	162	89	6	GO:0072073
GeneOntologyBiologicalProcess	histone mRNA metabolic process	TUT7 CPSF2 CPSF3	1.47e-04	24	89	3	GO:0008334
GeneOntologyBiologicalProcess	epithelium development	LHX1 ALMS1 TMTC3 CTNNBIP1 CGN GATA2 CDH23 ROBO1 PLXND1 REST SIM1 SLITRK6 SDC1 FOXC1 SMAD5 PCNT CCDC40	1.59e-04	1469	89	17	GO:0060429
MousePheno	abnormal ureter morphology	LHX1 CTNNBIP1 SCARB2 GATA2 ROBO1 FOXC1	7.25e-06	90	73	6	MP:0000534
Domain	ARHGEF5_35	ARHGEF35 ARHGEF5	2.30e-05	2	90	2	PF15441
Domain	ARHGEF5/35_N	ARHGEF35 ARHGEF5	2.30e-05	2	90	2	IPR029212
Domain	RMMBL	CPSF2 CPSF3	6.87e-05	3	90	2	IPR011108
Domain	RMMBL	CPSF2 CPSF3	6.87e-05	3	90	2	PF07521
Domain	Beta-Casp	CPSF2 CPSF3	1.37e-04	4	90	2	PF10996
Domain	Beta_Casp	CPSF2 CPSF3	1.37e-04	4	90	2	IPR022712
Domain	Beta-Casp	CPSF2 CPSF3	1.37e-04	4	90	2	SM01027
Domain	DOCK_N	DOCK3 DOCK4	2.27e-04	5	90	2	PF16172
Domain	DOCK_N	DOCK3 DOCK4	2.27e-04	5	90	2	IPR032376
Domain	DOCK_C	DOCK3 DOCK4	1.23e-03	11	90	2	IPR010703
Domain	DHR-1_domain	DOCK3 DOCK4	1.23e-03	11	90	2	IPR027007
Domain	DHR_2	DOCK3 DOCK4	1.23e-03	11	90	2	PS51651
Domain	DHR_1	DOCK3 DOCK4	1.23e-03	11	90	2	PS51650
Domain	DOCK-C2	DOCK3 DOCK4	1.23e-03	11	90	2	PF14429
Domain	DHR-2	DOCK3 DOCK4	1.23e-03	11	90	2	IPR027357
Domain	DHR-2	DOCK3 DOCK4	1.23e-03	11	90	2	PF06920
Domain	DOCK	DOCK3 DOCK4	1.23e-03	11	90	2	IPR026791
Domain	Lactamase_B	CPSF2 CPSF3	1.73e-03	13	90	2	PF00753
Domain	Lactamase_B	CPSF2 CPSF3	2.31e-03	15	90	2	SM00849
Domain	-	CPSF2 CPSF3	4.12e-03	20	90	2	3.60.15.10
Domain	Metallo-B-lactamas	CPSF2 CPSF3	4.12e-03	20	90	2	IPR001279
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DOCK3 PARP4 TBC1D9B ALMS1 CGN DIP2C IRF2BPL SSH2 NDRG2 KIAA2013	6.89e-07	493	91	10	15368895
Pubmed	Smicl is a novel Smad interacting protein and cleavage and polyadenylation specificity factor associated protein.	CPSF2 CPSF3 SMAD5	9.61e-07	8	91	3	16115198
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DOCK4 SYNE1 SNX27 CUL9 BOD1L1 FHIP2A CEP170B SON PCNT	1.27e-06	407	91	9	12693553
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	RANGAP1 RRP1B NAT10 CGN TMF1 SNX27 ROBO1 EIF3C SSH2 CPSF2 CPSF3 FOXC1 PCNT	3.46e-06	1049	91	13	27880917
Pubmed	Sim1 and Sim2 are required for the correct targeting of mammillary body axons.	LHX1 ROBO1 SIM1	3.75e-06	12	91	3	16291793
Pubmed	Molecular genetic analysis of patients with sporadic and X-linked infantile nystagmus.	FRMD7 GPR143	6.77e-06	2	91	2	27036142
Pubmed	Sry expression level and protein isoform differences play a role in abnormal testis development in C57BL/6J mice carrying certain Sry alleles.	LHX1 SRY	6.77e-06	2	91	2	12750339
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	RANGAP1 RRP1B TUT7 NAT10 CGN CUL9 ANKHD1 CPSF3 SON PCNT	8.34e-06	653	91	10	22586326
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RANGAP1 GTF3C2 RRP1B NAT10 PLXND1 CPSF2 ANKHD1 ARHGEF10L ZNF646	1.06e-05	529	91	9	14621295
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	TBC1D9B CUL9 BOD1L1 CPSF2 CPSF3 KIAA2013 SMAD5	1.90e-05	313	91	7	38270169
Pubmed	The dominant white spotting oncogene allele Kit(W-42J) exacerbates XY(DOM) sex reversal.	LHX1 SRY	2.03e-05	3	91	2	8951075
Pubmed	Characterization of cleavage and polyadenylation specificity factor and cloning of its 100-kilodalton subunit.	CPSF2 CPSF3	2.03e-05	3	91	2	7969155
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	ALMS1 TMTC3 CTNNBIP1 ASB6 TUT7 TMF1 ROBO1 BOD1L1 CPSF2 CPSF3	2.25e-05	733	91	10	34672954
Pubmed	DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.	SYNE1 ANKHD1 PCNT	2.57e-05	22	91	3	12812986
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	DOCK3 DOCK4 RANGAP1 ARHGEF5 CGN SDF2L1 ROBO1 CPSF2 FAM13B CPSF3 ARHGEF10L	2.77e-05	916	91	11	32203420
Pubmed	The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate.	LHX1 FOXC1 SMAD5	2.95e-05	23	91	3	15196959
Pubmed	High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.	RANGAP1 GTF3C2 RRP1B TUT7 EIF3C CPSF2 CPSF3 SON	3.29e-05	469	91	8	37314180
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	ZFAT ALMS1 XIRP2 SYNE1 PPP1R3F ANKHD1	3.51e-05	233	91	6	37704626
Pubmed	Hnf1b and Pax2 cooperate to control different pathways in kidney and ureter morphogenesis.	LHX1 SLC12A3 FOXC1	3.82e-05	25	91	3	22511595
Pubmed	Gene expression profiling and qRT-PCR expression of RRP1B, PCNT, KIF21A and ADRB2 in leucocytes of Down's syndrome subjects.	RRP1B PCNT	4.05e-05	4	91	2	22552340
Pubmed	Conserved motifs in both CPSF73 and CPSF100 are required to assemble the active endonuclease for histone mRNA 3'-end maturation.	CPSF2 CPSF3	4.05e-05	4	91	2	18688255
Pubmed	Sex reversal caused by Mus musculus domesticus Y chromosomes linked to variant expression of the testis-determining gene Sry.	LHX1 SRY	4.05e-05	4	91	2	10588871
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	PARP4 ZFAT ALMS1 XIRP2 SYNE1 EIF3C CLIP1 SON	4.95e-05	497	91	8	23414517
Pubmed	SMAD1 and SMAD5 Expression Is Coordinately Regulated by FLI1 and GATA2 during Endothelial Development.	GATA2 SMAD5	6.74e-05	5	91	2	25870111
Pubmed	A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs.	CPSF2 CPSF3	6.74e-05	5	91	2	18288197
Pubmed	Multiple forms of poly(A) polymerases in human cells.	CPSF2 CPSF3	6.74e-05	5	91	2	8302877
Pubmed	SON protein regulates GATA-2 through transcriptional control of the microRNA 23a~27a~24-2 cluster.	GATA2 SON	6.74e-05	5	91	2	23322776
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	RANGAP1 RRP1B ERAL1 SYNE1 NAT10 CGN EIF3C CPSF2 FOXC1 SON PCNT	7.54e-05	1024	91	11	24711643
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	DOCK4 RANGAP1 ALMS1 TUT7 CGN FHIP2A LRP1B CLIP1 CEP170B PCNT	8.01e-05	853	91	10	28718761
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	SERHL2 SYNE1 SNX27 FAM13B ZFPL1	8.24e-05	168	91	5	30631154
Pubmed	Human transcription factor protein interaction networks.	LHX1 ALMS1 GTF3C2 RRP1B NAT10 GATA2 CUL9 IRF2BPL EIF3C CPSF2 ANKHD1 FOXC1 SMAD5	8.76e-05	1429	91	13	35140242
Pubmed	Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract.	LHX1 FOXC1	1.01e-04	6	91	2	10704385
Pubmed	CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs.	CPSF2 CPSF3	1.01e-04	6	91	2	18305108
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	ALMS1 SYNE1 EIF3C SSH2 PCNT	1.36e-04	187	91	5	26460568
Pubmed	The poly A polymerase Star-PAP controls 3'-end cleavage by promoting CPSF interaction and specificity toward the pre-mRNA.	CPSF2 CPSF3	1.41e-04	7	91	2	21102410
Pubmed	Complex protein interactions within the human polyadenylation machinery identify a novel component.	CPSF2 CPSF3	1.41e-04	7	91	2	10669729
Pubmed	Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.	CPSF2 CPSF3	1.41e-04	7	91	2	22727665
Pubmed	The lhx2 transcription factor controls thalamocortical axonal guidance by specific regulation of robo1 and robo2 receptors.	LHX1 ROBO1	1.41e-04	7	91	2	22457488
Pubmed	A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development.	FOXC1 PCNT	1.41e-04	7	91	2	15314648
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DOCK3 TBC1D9B GATA2 DIP2C CUL9 PLXND1 ANKHD1 CEP170B KIAA2013 ARHGEF10L PCNT	1.47e-04	1105	91	11	35748872
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SYNE1 TUT7 NAT10 SSH2	1.53e-04	102	91	4	11214970
Pubmed	Hundreds of variants clustered in genomic loci and biological pathways affect human height.	DOCK3 ZFAT TUT7 TMEM176A LRRC37B	1.78e-04	198	91	5	20881960
Pubmed	Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.	KMT5B CACNA1I LRP1B CEP170B CCDC40	1.82e-04	199	91	5	23382691
Pubmed	RBBP6 activates the pre-mRNA 3' end processing machinery in humans.	CPSF2 CPSF3	1.88e-04	8	91	2	35177536
Pubmed	Comparative genome mapping in the sequence-based era: early experience with human chromosome 7.	DOCK4 ARHGEF5	1.88e-04	8	91	2	10810084
Pubmed	GATA2 is required for the generation of V2 interneurons.	LHX1 GATA2	1.88e-04	8	91	2	10934027
Pubmed	The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation.	CPSF2 CPSF3	1.88e-04	8	91	2	7590244
Pubmed	Preformed Wolffian duct regulates Müllerian duct elongation independently of canonical Wnt signaling or Lhx1 expression.	LHX1 SMAD5	1.88e-04	8	91	2	25896202
Pubmed	Global landscape of HIV-human protein complexes.	PARP4 ALMS1 SDF2L1 EIF3C ANKHD1 KIAA2013 FOXC1	2.02e-04	457	91	7	22190034
Pubmed	Phosphoproteome analysis of the human mitotic spindle.	RANGAP1 RRP1B CLIP1 SON PCNT	2.34e-04	210	91	5	16565220
Pubmed	DNA cloning using in vitro site-specific recombination.	SLC12A3 TMTC3 TUT7 NAT10 SIM1 SLITRK6 ZNF649 NDRG2 TMEM117	2.38e-04	794	91	9	11076863
Pubmed	Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase.	CPSF2 CPSF3	2.41e-04	9	91	2	14749727
Pubmed	The C-terminal domain of RNA polymerase II couples mRNA processing to transcription.	CPSF2 CPSF3	2.41e-04	9	91	2	9002523
Pubmed	Spatiotemporal Decline of BMP Signaling Activity in Neural Progenitors Mediates Fate Transition and Safeguards Neurogenesis.	LHX1 SMAD5	2.41e-04	9	91	2	32187534
Pubmed	Foxc1 controls the growth of the murine frontal bone rudiment by direct regulation of a Bmp response threshold of Msx2.	FOXC1 SMAD5	2.41e-04	9	91	2	23344708
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	RANGAP1 GTF3C2 NAT10 SNX27 BOD1L1 CPSF2	2.44e-04	332	91	6	32786267
Pubmed	Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.	GTF3C2 CPSF2 ZNF649 CPSF3	2.51e-04	116	91	4	21549307
Pubmed	Tcf7l2 plays crucial roles in forebrain development through regulation of thalamic and habenular neuron identity and connectivity.	EFS GATA2 ROBO1	2.58e-04	47	91	3	28219675
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	RRP1B NAT10 EIF3C SDC1 FOXC1 ZNF646	3.18e-04	349	91	6	25665578
Pubmed	Immune-related zinc finger gene ZFAT is an essential transcriptional regulator for hematopoietic differentiation in blood islands.	ZFAT GATA2	3.67e-04	11	91	2	20660741
Pubmed	Pax6 is required intrinsically by thalamic progenitors for the normal molecular patterning of thalamic neurons but not the growth and guidance of their axons.	LHX1 ROBO1	3.67e-04	11	91	2	26520399
Pubmed	Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration.	CPSF2 CPSF3	3.67e-04	11	91	2	33469008
Pubmed	Reduced BMP4 abundance in Gata2 hypomorphic mutant mice result in uropathies resembling human CAKUT.	GATA2 FOXC1	3.67e-04	11	91	2	18233958
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	ALMS1 HACE1 CUL9 PLXND1	3.87e-04	130	91	4	12421765
Pubmed	USP45 and Spindly are part of the same complex implicated in cell migration.	ERAL1 TUT7 CDH23 EIF3C PLXND1	3.91e-04	235	91	5	30258100
Pubmed	Notch signaling promotes nephrogenesis by downregulating Six2.	LHX1 SLC12A3	4.39e-04	12	91	2	27633993
Pubmed	A critical role for endoglin in the emergence of blood during embryonic development.	GATA2 SMAD5	4.39e-04	12	91	2	22535663
Pubmed	Patterning of the basal telencephalon and hypothalamus is essential for guidance of cortical projections.	ROBO1 SIM1	4.39e-04	12	91	2	11830575
Pubmed	Nucleophosmin deposition during mRNA 3' end processing influences poly(A) tail length.	CPSF2 CPSF3	4.39e-04	12	91	2	21822216
Pubmed	Global phosphoproteome of HT-29 human colon adenocarcinoma cells.	CGN EIF3C CLIP1	5.07e-04	59	91	3	16083285
Pubmed	Two-marker association tests yield new disease associations for coronary artery disease and hypertension.	ZFAT STK32B	5.18e-04	13	91	2	21626137
Pubmed	The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family.	DOCK3 DOCK4	5.18e-04	13	91	2	21930703
Pubmed	Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney.	LHX1 SLC12A3	5.18e-04	13	91	2	17314325
Pubmed	Genetic dissection of Gata2 selective functions during specification of V2 interneurons in the developing spinal cord.	LHX1 GATA2	5.18e-04	13	91	2	25369423
Pubmed	V1 and v2b interneurons secure the alternating flexor-extensor motor activity mice require for limbed locomotion.	GATA2 SIM1	5.18e-04	13	91	2	24698273
Pubmed	Transcription factor TFIID recruits factor CPSF for formation of 3' end of mRNA.	CPSF2 CPSF3	5.18e-04	13	91	2	9311784
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	RANGAP1 GTF3C2 TMTC3 RRP1B NAT10 GATA2 REST CPSF2 CPSF3 FOXC1 SON	5.63e-04	1294	91	11	30804502
Pubmed	Identifying genes differentially expressed between PGCs and ES cells reveals a role for CREB-binding protein in germ cell survival.	LHX1 SRY	6.04e-04	14	91	2	17936260
Pubmed	The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors.	CPSF2 CPSF3	6.04e-04	14	91	2	19136632
Pubmed	GABAergic and glutamatergic identities of developing midbrain Pitx2 neurons.	LHX1 GATA2	6.04e-04	14	91	2	21246650
Pubmed	Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.	DOCK3 DOCK4	6.04e-04	14	91	2	12432077
Pubmed	Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity.	GATA2 SIM1	6.04e-04	14	91	2	19666821
Pubmed	Pellino-2 in nonimmune cells: novel interaction partners and intracellular localization.	ROBO1 CEP170B	6.04e-04	14	91	2	34674267
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	RANGAP1 ALMS1 GTF3C2 NAT10 CGN BOD1L1 ANKHD1	6.07e-04	549	91	7	38280479
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ALMS1 KMT5B P3H3 NAT10 CUL9 ANKHD1 CEP170B FOXC1 SON ZNF646	6.80e-04	1116	91	10	31753913
Pubmed	Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2.	LHX1 SRY	6.95e-04	15	91	2	12223418
Pubmed	Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling.	LHX1 SIM1	6.95e-04	15	91	2	9230312
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	NEK5 SYNE1 CDH23 REST	6.98e-04	152	91	4	34299191
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	CGN HACE1 BOD1L1 CPSF2	7.15e-04	153	91	4	10718198
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	RANGAP1 ALMS1 NAT10 BOD1L1 EIF3C ANKHD1 CPSF3 SON PCNT	7.67e-04	934	91	9	33916271
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	RANGAP1 RRP1B NAT10 CPSF2 CPSF3	7.83e-04	274	91	5	34244482
Pubmed	Bone morphogenic protein signaling is a major determinant of dentate development.	FOXC1 SMAD5	7.93e-04	16	91	2	23595735
Pubmed	The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics.	ADRA1A SLC12A3	7.93e-04	16	91	2	15824464
Pubmed	Sox2 in the dermal papilla niche controls hair growth by fine-tuning BMP signaling in differentiating hair shaft progenitors.	SDC1 SMAD5	7.93e-04	16	91	2	23153495
Pubmed	Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/fork head proteins.	GATA2 FOXC1	7.93e-04	16	91	2	10208738
Pubmed	Bmp7 drives proximal tubule expansion and determines nephron number in the developing kidney.	SLC12A3 SMAD5	7.93e-04	16	91	2	35877077
Pubmed	Hairy/Enhancer-of-Split MEGANE and Proneural MASH1 Factors Cooperate Synergistically in Midbrain GABAergic Neurogenesis.	LHX1 GATA2	7.93e-04	16	91	2	25993409
Pubmed	Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.	TMTC3 TUT7 NAT10 SLITRK6 ANKHD1 ZNF649 NDRG2 TMEM117	7.94e-04	750	91	8	11230166
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	PARP4 RANGAP1 ERAL1 NAT10 CPSF2 CPSF3 PCNT	8.54e-04	582	91	7	20467437
Pubmed	Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development.	LHX1 GATA2	8.98e-04	17	91	2	19607821
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF35 ARHGEF5 ARHGEF10L	9.04e-04	66	52	3	722
ToppCell	distal-Hematologic-Plasmacytoid_Dendritic-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	UBQLNL ZFAT SLC12A3 STK32B IRF2BPL LRP1B LILRB4	1.59e-07	196	91	7	170629b9ae82e9a911b93e8739dcd38176fbecb4
ToppCell	control-Lymphoid-CTL\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	PARP4 PAG1 SYNE1 REST FCRL6 SON	2.84e-06	193	91	6	89d407a88b5956559a589425b89b3eb8dc78e1dd
ToppCell	distal-1-Hematologic-Plasmacytoid_Dendritic\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	UBQLNL ZFAT SLC12A3 STK32B LRP1B LILRB4	3.19e-06	197	91	6	166d47359df9279ea8c3946f10bd3d4b88c95857
ToppCell	NS-critical-LOC-Myeloid-Macrophage\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SCARB2 TMEM176A PLXND1 IL4I1 ARHGEF10L LILRB4	3.19e-06	197	91	6	5fb0696376a5501b7c87e0f2f5e4fff3da2903f2
ToppCell	(09)_Interm._secr.>cil.-(2)_GFP_FOXI1\|(09)_Interm._secr.>cil. / shred by cell type by condition	TMTC3 TMF1 BOD1L1 REST CLIP1 SMAD5	3.39e-06	199	91	6	fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DOCK3 SYNE1 GPR143 SLITRK6 IRAG1 NDRG2	3.48e-06	200	91	6	08bf8c00eee6468215edb3611296bfc8784c4d56
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_7\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LHX1 CTNNBIP1 NDRG2 ARHGEF10L LILRB4	9.50e-06	138	91	5	c172880eda7b8b8b758dbbc77f93191238f3181c
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_7\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	LHX1 CTNNBIP1 NDRG2 ARHGEF10L LILRB4	9.84e-06	139	91	5	313f7e66ed94950129c7146a2afe2feb8951fe1e
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LHX1 FRMD7 GATA2 SIM1 TMEM117	1.94e-05	160	91	5	86fde32f096eaf9ea3677f57169cdcc0a57bb8dd
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DOCK3 PAG1 DIP2C PPP1R3F IL4I1	2.00e-05	161	91	5	580153e131247e6ec12a1a920f050a0a763e7e87
ToppCell	3'-Distal_airway-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ZFAT SLC12A3 CUL9 IL4I1 LILRB4	2.12e-05	163	91	5	3087224d3f16f5d3aecc3e1e4366220231afe31f
ToppCell	PND14-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TBC1D9B SYNE1 GATA2 SSH2 LILRB4	2.19e-05	164	91	5	f4de9f18134a06f3d7fcf5b50b8e21c1506e2083
ToppCell	PND14-Immune-Immune_Myeloid-Granulocytic-Basophil\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TBC1D9B SYNE1 GATA2 SSH2 LILRB4	2.19e-05	164	91	5	dc22b1fef49c1557a0b63c536eaba574dfcab715
ToppCell	368C-Myeloid-Dendritic-cDC_activated\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	DOCK3 EFS P3H3 CAMK1G IL4I1	2.25e-05	165	91	5	9d2bdc42c13c8c2a68889bec8612a1ce56f659fa
ToppCell	10x5'v1-week_12-13-Myeloid_DC-DC-pDC\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ZFAT SLC12A3 SCARB2 CDH23 LILRB4	2.32e-05	166	91	5	9fa90d9d484563d44738bb2c6eb0775dffc4d549
ToppCell	E18.5-Immune-Immune_Myeloid-Granulocytic-Basophil\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PAG1 SYNE1 GATA2 SSH2 LILRB4	2.52e-05	169	91	5	b23d0aaa2da333b9c69a7aee862d5a5d2a1bf79b
ToppCell	E18.5-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PAG1 SYNE1 GATA2 SSH2 LILRB4	2.52e-05	169	91	5	83d1bcf33872b01ea9614f608a3e4ab30df25c7e
ToppCell	COVID-19_Mild-NK_activated\|COVID-19_Mild / Disease condition and Cell class	KMT5B SYNE1 TUT7 DTX3L EIF3C	3.69e-05	183	91	5	22bd05135906d0ecc4ba8c2e0a666093d1bf3b8f
ToppCell	droplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EFS P3H3 FRMD7 STK32B ROBO1	3.89e-05	185	91	5	1b990e3089772be2b38c6d7ea0d1bf22461ae3ea
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK4 SYNE1 ROBO1 CAMK1G IRAG1	4.09e-05	187	91	5	15d6e158562d7d85af3ceaf955439b379c8fce81
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LHX1 SLC12A3 CGN SIM1 LRP1B	4.09e-05	187	91	5	f124d2c699b717b7c02a1a70493f515b83dc2f4c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK4 SYNE1 ROBO1 CAMK1G IRAG1	4.09e-05	187	91	5	f62074b631fd45ad299c69d71b09267b04d656ee
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK4 SYNE1 ROBO1 CAMK1G IRAG1	4.20e-05	188	91	5	32f22a4d8cb98fd8b8fa0fbf28ef9266d711d081
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LHX1 SLC12A3 STK32B SIM1 NDRG2	4.20e-05	188	91	5	d2d2b6c49448da24f457cedcd213f68841834a99
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LHX1 SLC12A3 STK32B SIM1 NDRG2	4.20e-05	188	91	5	ab6fa1beff91584d9303c2a33735de89aae8d5cd
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK3 SLC12A3 STK32B SIM1 LRP1B	4.31e-05	189	91	5	f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LHX1 SLC12A3 CGN SIM1 LRP1B	4.31e-05	189	91	5	e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCell	droplet-Heart-nan-24m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	P3H3 GATA2 TMEM176A PLXND1 FOXC1	4.31e-05	189	91	5	1137583e21d874c201c20581ba1995e2bfa3de59
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LHX1 SLC12A3 STK32B SIM1 LRP1B	4.31e-05	189	91	5	55420853f730b433ef58ac9337ac84ac78a247a0
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PARP4 ARHGEF35 ARHGEF5 SYNE1 FOXC1	4.41e-05	190	91	5	b855b8b7d3439023390ca44629c1a99f5d4c6801
ToppCell	10x5'v1-week_14-16-Myeloid_DC-DC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ZFAT SLC12A3 NDRG2 LRP1B LILRB4	4.41e-05	190	91	5	d06800ec9f6065c1cc536ed99e8569732272a94f
ToppCell	10x5'v1-week_14-16-Myeloid_DC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ZFAT SLC12A3 NDRG2 LRP1B LILRB4	4.41e-05	190	91	5	485073e831afebdb393c7f4b622504d43d1b778b
ToppCell	COVID-19_Moderate-pDC\|COVID-19_Moderate / disease group, cell group and cell class	ZFAT SLC12A3 SCARB2 CDH23 LILRB4	4.53e-05	191	91	5	9d0ffa65c547e20b4076fd97776d7738cbd453ec
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DOCK3 PAG1 ROBO1 SLITRK6 IRAG1	4.64e-05	192	91	5	72881b280a415e65f87a80ca1369cbb0b722a0c4
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LHX1 SLC12A3 STK32B SIM1 NDRG2	4.64e-05	192	91	5	6fb56d062c35617b18b927704bf5fba894faed81
ToppCell	10x5'v1-week_17-19-Myeloid_DC-DC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	ZFAT SLC12A3 NDRG2 LRP1B LILRB4	4.76e-05	193	91	5	bdbbfcbe339f23a88dfcc59d53c034bac1605b07
ToppCell	10x5'v1-week_17-19-Myeloid_DC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	ZFAT SLC12A3 NDRG2 LRP1B LILRB4	4.76e-05	193	91	5	acafe177cd05b2966f5fa26ea02f420f13f2cee5
ToppCell	Mild-Myeloid-Macrophages-FCN1_high\|Mild / Condition, Lineage, Cell class and cell subclass	DOCK4 STK32B TMEM176A IL4I1 LILRB4	5.37e-05	198	91	5	17aab4dc3b2cd6eb7dda77dd51bdc20490fcfe19
ToppCell	NS-critical-d_0-4-Myeloid-Non-resident_Macrophage\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SCARB2 TMEM176A PLXND1 IL4I1 LILRB4	5.37e-05	198	91	5	49fc6ba574ed5c848eaa329aad1d5c8091c79f47
ToppCell	critical-Myeloid-Non-resident_Macrophage\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SCARB2 TMEM176A PLXND1 IL4I1 LILRB4	5.50e-05	199	91	5	193325768b17d3123ae855317f381a01088b5dac
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	GPR143 ROBO1 SLITRK6 IRAG1 NDRG2	5.50e-05	199	91	5	38cfd367ee8c074c11ba54edeb7a001e375e2687
ToppCell	mLN-(5)_Dendritic_cell-(54)_pDC\|mLN / shred on region, Cell_type, and subtype	ZFAT SCARB2 STK32B CDH23 LILRB4	5.50e-05	199	91	5	1e738219784a446ee8b0ddeb408e0050e1929e60
ToppCell	mLN-Dendritic_cell-pDC\|mLN / Region, Cell class and subclass	ZFAT SCARB2 STK32B CDH23 LILRB4	5.50e-05	199	91	5	54f1abb57af7bf8a8b82a38b933f257df3b5d8df
ToppCell	Control_saline-Mesenchymal_fibroblastic\|Control_saline / Treatment groups by lineage, cell group, cell type	DOCK4 SYNE1 ROBO1 SLITRK6 NDRG2	5.63e-05	200	91	5	64ae5cf6cb4fc94cf1052abd82648f6b8e6445fe
ToppCell	control\|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	TMTC3 CGN NDRG2 SDC1 FOXC1	5.63e-05	200	91	5	97f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DOCK3 SYNE1 GPR143 IRAG1 NDRG2	5.63e-05	200	91	5	f599e4b051ac3dad11ad437e98dc8ea6754cca53
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SYNE1 GPR143 IRAG1 NDRG2 LRP1B	5.63e-05	200	91	5	7a8160e6477708f22e48c609bf8f43f3715dcb03
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DOCK3 SYNE1 SLITRK6 IRAG1 NDRG2	5.63e-05	200	91	5	87827041663013f5e7273168dc8709d69840e7ce
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SYNE1 GPR143 IRAG1 NDRG2 LRP1B	5.63e-05	200	91	5	07d942803360e1a1e8e131d6e31c726dd0db1a0b
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SYNE1 GPR143 IRAG1 NDRG2 LRP1B	5.63e-05	200	91	5	d0812817ef99608994193787a62d39adeb2070ca
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|Control_saline / Treatment groups by lineage, cell group, cell type	GPR143 ROBO1 SLITRK6 IRAG1 NDRG2	5.63e-05	200	91	5	a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DOCK3 SYNE1 SLITRK6 IRAG1 NDRG2	5.63e-05	200	91	5	8988f113708eef7d9d2a6a6c1bcfd7c8f9804d3e
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic\|LPS_only / Treatment groups by lineage, cell group, cell type	SYNE1 GPR143 SLITRK6 IRAG1 NDRG2	5.63e-05	200	91	5	02cae2c296a13ad4cbb53bca7a86d64629d67d66
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts\|Control_saline / Treatment groups by lineage, cell group, cell type	DOCK4 SYNE1 ROBO1 SLITRK6 NDRG2	5.63e-05	200	91	5	a1fc74c1b27e104895910bc7cdce7ba33d30df7e
ToppCell	BL-critical-LOC-Myeloid-Macrophage\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SCARB2 TMEM176A PLXND1 IL4I1 LILRB4	5.63e-05	200	91	5	dc3d5af1d4b15cc258d456f9f450550874456299
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SYNE1 GPR143 IRAG1 NDRG2 LRP1B	5.63e-05	200	91	5	cd54ddf1919c98e84b7e4aba85b374fc8b407206
ToppCell	PND14-Immune-Immune_Myeloid-Granulocytic\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SYNE1 GATA2 SSH2 LILRB4	2.05e-04	142	91	4	bf3537bec0eca9f90c00df9ba840c371f1c9856e
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EFS ROBO1 CAMK1G IRAG1	2.41e-04	148	91	4	f85dc34f6a4a15ecffa4fbd5644dea12ce30089b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EFS ROBO1 CAMK1G IRAG1	2.41e-04	148	91	4	4b1fdf90c585f89cee1cf521db4e3fafc9d74d9a
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Thalamus / BrainAtlas - Mouse McCarroll V32	LHX1 CACNA1I CAMK1G SIM1	2.41e-04	148	91	4	afebb64365c94b9476494bffe7c364677f19c8cf
ToppCell	Thalamus-Neuronal-Inhibitory\|Thalamus / BrainAtlas - Mouse McCarroll V32	LHX1 CACNA1I CAMK1G SIM1	2.41e-04	148	91	4	5f82e5ecacfd223020b8ee975c17d68c1fe6db38
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EFS ROBO1 CAMK1G IRAG1	2.41e-04	148	91	4	55826b7e9f79ab78a93abd4fc662bc37aa121471
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 ROBO1 CAMK1G IRAG1	2.53e-04	150	91	4	8645b9c7f9511ed6cc9afe04440c2873a3094150
ToppCell	COVID-19-Mast_cells-Mast_cells\|COVID-19 / group, cell type (main and fine annotations)	PAG1 GATA2 DIP2C LRP1B	2.94e-04	156	91	4	bc10b94673184ef384c6665b16a1209a8975a4f1
ToppCell	COVID-19-Mast_cells\|COVID-19 / group, cell type (main and fine annotations)	PAG1 GATA2 DIP2C LRP1B	2.94e-04	156	91	4	159504d43421ee83b9ab484816333ae549c9c2fd
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_0\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	RANGAP1 STK32B TMEM176A ARHGEF10L	3.16e-04	159	91	4	2f6c60ddff2208a68146f9786143d9aefd528840
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_0\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RANGAP1 STK32B TMEM176A ARHGEF10L	3.16e-04	159	91	4	ded4e3626a62fb6334403b7213b467fb7e8131c3
ToppCell	CV-Healthy-3\|CV / Virus stimulation, Condition and Cluster	DOCK3 TMTC3 CDH23 ZNF646	3.31e-04	161	91	4	fd4a79385ea967b9900dc76a3add813b894a3a28
ToppCell	Basal_cells-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	GPR143 PPP1R3F ROBO1 SLITRK6	3.55e-04	164	91	4	b15a26130a1ea1b370b6e3be21f02a0d6aaf6b3c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ROBO1 CAMK1G PLXND1 IRAG1	3.55e-04	164	91	4	b6df1e67a5ce5f2d86f4e1420f4ee931f760bf4d
ToppCell	368C-Myeloid-Dendritic-cDC_activated\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	DOCK3 EFS CAMK1G IL4I1	3.55e-04	164	91	4	67c636a2cc32e56c6186dc7e779cc19af04639d2
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RANGAP1 IL4I1 FCRL6 MIR9-1HG	3.55e-04	164	91	4	30c3c25b05a403a509b2e755c2f0878fecb10a02
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK4 CDH23 CACNA1I PLXND1	3.64e-04	165	91	4	6a621b300442c52adfc15b61d3a6d3a3cb00099f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 ROBO1 CAMK1G IRAG1	3.64e-04	165	91	4	e2aebb2fe197151e019371b8960f76f0c2386f08
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 ROBO1 CAMK1G IRAG1	3.64e-04	165	91	4	b087771499aeb31cc4a338d2d0a9392a4ec1ac45
ToppCell	nucseq-Immune-Hematopoietic-Granulocytic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PARP4 GATA2 DIP2C LRP1B	3.64e-04	165	91	4	37615622c736e43260c38016e7c9e565ac97a3e8
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 ROBO1 CAMK1G IRAG1	3.64e-04	165	91	4	d8f8b088fd28a6b9dbd6b51bcaee42000e963321
ToppCell	nucseq-Immune-Hematopoietic-Granulocytic-Mast/Basophil\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PARP4 GATA2 DIP2C LRP1B	3.64e-04	165	91	4	640bb71e74a61df2fcb01ceeabe4c493ef836b21
ToppCell	nucseq-Immune-Hematopoietic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PARP4 GATA2 DIP2C LRP1B	3.64e-04	165	91	4	f3df74b5763130c71c0a482a3a23f6b22acc2892
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-plasma_cell-plasma_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC12A3 CDH23 SDF2L1 SDC1	3.81e-04	167	91	4	8ec7a98b542b134f48df8fbec351693cc5cfe55c
ToppCell	367C-Myeloid-Dendritic-pDC\|367C / Donor, Lineage, Cell class and subclass (all cells)	UBQLNL ZFAT SLC12A3 LILRB4	3.81e-04	167	91	4	650de8cd5df070639b8aa292aacead739cfdb02c
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-plasma_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC12A3 CDH23 SDF2L1 SDC1	3.81e-04	167	91	4	a9f28c4649ce344ae3ba3a3acb58da9c7efad901
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Meis2-Meis2_Adamts19\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LHX1 FRMD7 SON	3.81e-04	69	91	3	130b1a56afe6aee01cde56cb983cbc2c41861bb4
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Meis2\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LHX1 FRMD7 SON	3.81e-04	69	91	3	6568fcefcc0dca211f2acf6e4066f795489e758d
ToppCell	PND03-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	UBQLNL ALMS1 SDF2L1 LILRB4	3.89e-04	168	91	4	cc0dd43d5cda01e643d8e8d74ec7617d61890760
ToppCell	Children_(3_yrs)-Immune-enucleated_erythrocyte-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CTNNBIP1 P3H3 STK32B LILRB4	3.89e-04	168	91	4	8f0c4dfad9f6fed9dcc31795abfe77758ceb46a1
ToppCell	Tracheal-10x5prime-Immune_Myeloid-Dendritic_cell-DC_plasmacytoid\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ZFAT SLC12A3 IL4I1 LILRB4	3.89e-04	168	91	4	c34dd4a9c54d8e9c8f118e6a3816548890cb0746
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC12A3 CDH23 SDF2L1 SDC1	3.98e-04	169	91	4	e348d9877a1bcad4f33dd7b2ce6cb0049583c4d2
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-Plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC12A3 CDH23 SDF2L1 SDC1	3.98e-04	169	91	4	3167ca0c826244280e0e07d1e02656cf5e4e75a5
ToppCell	COVID-19-lung-MAST\|lung / Disease (COVID-19 only), tissue and cell type	PARP4 PAG1 GATA2 DIP2C	4.07e-04	170	91	4	e90f18e5462381b38e918442b38b1c8105291908
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage_4\|390C / Donor, Lineage, Cell class and subclass (all cells)	SCARB2 ZNF625 TMEM117 LILRB4	4.07e-04	170	91	4	439167e44a1bd5ac8e1e457351dd202ec968db46
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 ROBO1 CAMK1G IRAG1	4.07e-04	170	91	4	876b84740e15399bfff2b9c7f0b80fd759bbdb3f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 ROBO1 CAMK1G IRAG1	4.07e-04	170	91	4	1f8738acf439d893880db7e1fdc9b3615ca00c39
ToppCell	droplet-Lung-nan-18m-Myeloid-Interstitial_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZFAT SLC12A3 TMEM176A LILRB4	4.16e-04	171	91	4	7ca404539344e14dcd90c746c9122f713a7db78b
ToppCell	droplet-Lung-nan-18m-Myeloid-lung_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZFAT SLC12A3 TMEM176A LILRB4	4.16e-04	171	91	4	ab113c8e773b0af47a87aed50e96be3ba71c3c82
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage_4\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	SCARB2 ZNF625 SDC1 TMEM117	4.16e-04	171	91	4	7c8304573b892ef9ea4e048cba9ea9fbab848dcd
ToppCell	ICU-SEP-Myeloid-pDC\|ICU-SEP / Disease, Lineage and Cell Type	ZFAT SLC12A3 CEP170B LILRB4	4.16e-04	171	91	4	72c448a0dc4c569bd6b465f9aa395f38034e7ea6
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ZFAT GATA2 PLXND1 FOXC1	4.25e-04	172	91	4	c3a99828838af3b85c8c885d69cc8018f55ced50
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 ROBO1 CAMK1G IRAG1	4.25e-04	172	91	4	08a3fe536b1b064c5ee7779bc2b1115a5963a26b
ToppCell	droplet-Marrow-nan-3m-Hematologic-proerythroblast\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LHX1 SYNE1 CLIP1 LILRB4	4.25e-04	172	91	4	cfcfa7eeff1805bedf10a3c07826459914c3e872
Disease	temporal horn of lateral ventricle volume measurement	EPM2A DIP2C IRAG1 SDC1	6.51e-05	72	88	4	EFO_0010333
Disease	Malignant neoplasm of breast	ADRA1A TBC1D9B SYNE1 DIP2C ROBO1 BOD1L1 DTX3L SIM1 CLIP1 CPSF3 ZNF646	3.49e-04	1074	88	11	C0006142
Disease	ocular hypertension, response to triamcinolone acetonide	SERHL2 TUT7 CDH23	4.28e-04	49	88	3	EFO_0006954, EFO_1001069
Disease	lifestyle measurement	DOCK3 SIM1 SLITRK6 FHIP2A ZNF646	7.03e-04	235	88	5	EFO_0010724
Disease	N-acetylmethionine measurement	DOCK3 ALMS1	9.00e-04	15	88	2	EFO_0021427
Disease	executive function measurement	RANGAP1 ADRA1A STK32B CUL9 LRP1B ARHGEF10L	9.26e-04	376	88	6	EFO_0009332
Disease	Action Myoclonus-Renal Failure Syndrome	EPM2A SCARB2	1.30e-03	18	88	2	C0751779
Disease	unipolar depression, bipolar disorder, schizophrenia, sex interaction measurement	PAG1 ZFAT LRP1B	1.54e-03	76	88	3	EFO_0003761, EFO_0008343, MONDO_0004985, MONDO_0005090
Disease	migraine disorder, Headache	REST IRAG1 MIR9-1HG	2.19e-03	86	88	3	HP_0002315, MONDO_0005277

Protein segments in the cluster

Peptide	Gene	Start	Entry
MHPKEGAEQHVFSPV	EPM2A	1	B3EWF7
DKPDGQAHEPMPDSH	ARHGEF10L	1146	Q9HCE6
QAHEPMPDSHVGREL	ARHGEF10L	1151	Q9HCE6
PPHVILVHGEQNEMA	CPSF3	411	Q9UKF6
HEVPGHQSVFMNEPR	CPSF2	706	Q9P2I0
HPPSQAVEGQHKDMV	ADRA1A	361	P35348
REEENEHHGPSMPAL	ARHGEF5	396	Q12774
VDDQMNKHHFPLPQG	ALMS1	2976	Q8TCU4
REEENEHHGPSMPAL	ARHGEF35	396	A5YM69
PDMVELLVHHGADVN	ASB6	116	Q9NWX5
QSSERQHHPLGPTDM	CEP170B	1006	Q9Y4F5
THAMLDRENPDPHEA	CDH23	836	Q9H251
VPDVMAPQHDQEKFH	MIR9-1HG	91	Q13536
EEVHMPQNGINHPGI	RANGAP1	211	P46060
GEQEQRMDLSHPVHA	P3H3	571	Q8IVL6
HAQMEGAQIRPAPDE	REST	636	Q13127
MDGSHRHKVPNQDIP	LRP1B	3201	Q9NZR2
HGAQQHQAEFPMSPV	LILRB4	171	Q8NHJ6
AVPDLMGPHSDQGEH	KMT5B	641	Q4FZB7
SPQAGRMNHHPLEED	FAM13B	501	Q9NYF5
PHPASDGEGMQIHLA	FRMD7	191	Q6ZUT3
LHHGPADPAVGDMVQ	FCRL6	211	Q6DN72
GHSQQEAAMPHIPED	IRAG1	36	Q9Y6F6
HPGMDQVHPQNIPDS	IRF2BPL	691	Q9H1B7
GEPVHHVMQFDPADS	PLXND1	516	Q9Y4D7
PVHQDASEGEAPVQM	NEK5	511	Q6P3R8
EQDVLLVHHPDMPEN	ERAL1	96	O75616
HSGQPDSDMVHRPVN	HACE1	536	Q8IYU2
GNHLSHPPEMNEAAV	LHX1	391	P48742
NHEVTVQPPGEDQAH	LRRC37B	321	Q96QE4
IDETMIHNGPPHNSN	GFUS	126	Q13630
MPGDQIKDFHPSDHT	PARP4	566	Q9UKK3
QCGMFTVSDHPPEQH	PCNT	116	O95613
SPNDLQMLSDAPAHH	NAT10	541	Q9H0A0
GIDPMEQPHSTQHVE	MAS1L	351	P35410
HMNLHSPGVRPEVEN	CAMK1G	321	Q96NX5
ADDMPPVQGTVAEHS	BOD1L1	2536	Q8NFC6
MSHLQDNIQHADPPV	EIF3C	591	Q99613
MAHPAVLNAQHPDSH	GATA2	11	P23769
QAVAMQHPNHPDDAI	DOCK3	1396	Q8IZD9
FPHAIAMQHANQPDE	DOCK4	1356	Q8N1I0
TPSGDMHQHEGHIPN	DTX3L	111	Q8TDB6
PPHHSQGFSVDNIMT	FOXC1	301	Q12948
SMGIEHHEQPEELTN	CACNA1I	656	Q9P0X4
AAEGAHPSPLMPHEN	GPR143	336	P51810
NNESHMVSPPEKDDG	CCDC40	26	Q4G0X9
MAQTHIENHSAPPDV	DIP2C	196	Q9Y2E4
PEGREMEDDPAGHHN	EFS	356	O43281
SQSQNHPVLDMGPHR	CUL9	1736	Q8IWT3
QTELEDEPPHQMDHL	FHIP2A	221	Q5W0V3
EVPGNHCVHMSEPQH	SERHL2	281	Q9H4I8
QAQMSEDPPHSTHHG	CLIP1	1396	P30622
PVVAMTQGPHDVHVQ	IL4I1	286	Q96RQ9
NNHSSIPMDPEHVEL	MEA1	126	Q16626
PHSHDPRDLQNMLDG	GARIN2	21	Q8N9W8
EESGSEHPPAVPMHN	RRP1B	456	Q14684
QLQPDMEAHYPGAHE	SLITRK6	781	Q9H5Y7
EPGRSPESQMAEHQA	SYNE1	5991	Q8NF91
SDEMAPEAPQHTHID	TMEM176A	6	Q96HP8
PVMLVVGDQAPHEDA	NDRG2	256	Q9UN36
MPPPSELGHVHAQAQ	SPPL2C	641	Q8IUH8
VTSHLRMQPDPAQGH	SIM1	741	P81133
SAIEGMHPNQEDHET	SCARB2	351	Q14108
QEPATSHPHRDMQPG	SDC1	146	P18827
PRQHSGDHENLMNVP	PAG1	46	Q9NWQ8
SHNEPHMPQNATFPD	SMAD5	161	Q99717
DLHRSMPEHPAFQNE	TBC1D9B	556	Q66K14
IEDHNENGHTPLMEA	ANKHD1	331	Q8IWZ3
DQQEAAPPGSVDHMK	CGN	301	Q9P2M7
PPHSIDQGAEDVVMA	CTNNBIP1	56	Q9NSA3
EESHNIMPSIDHIQG	XIRP2	1226	A4UGR9
LSQDESHDHSFGPMP	TMF1	951	P82094
AEAHAAPEKPPDMQH	ZFAT	606	Q9P243
AMEDQESLENPGAPH	SSH2	1301	Q76I76
PIRGQHEVHGMPSAN	SDF2L1	181	Q9HCN8
PQHMAEEGPGQAEVE	ZNF646	1136	O15015
MQAHINPVFDPAEDG	SLC12A3	786	P55017
MADEDGEGIHPSAPH	SNX27	1	Q96L92
FAMAEHPDVQESVGP	PPP1R3F	351	Q6ZSY5
QDCPEETGHMQHQPD	ROBO1	1276	Q9Y6N7
HQPTGMNQAPVELAH	UBQLNL	136	Q8IYU4
MGGNHSHKPPVFDEN	STK32B	1	Q9NY57
MEHQLGHLPPINAAS	SRY	176	Q05066
PDMNETHPLSQLHSG	GTF3C2	421	Q8WUA4
DVDVNLPGLHTPHMQ	TMEM117	266	Q9H0C3
DHQHGEILTQVPDDM	ZNF625	11	Q96I27
QATHVQPDDIGAHMN	TMTC3	471	Q6ZXV5
EMGNEHISVHPENSD	TUT7	711	Q5VYS8
GMQEIALHSGEEPHA	SON	1501	P18583
GRPEQHTVIHMGNPE	ZFPL1	191	O95159
GAFLHDNHEQMPTEI	ZNF649	136	Q9BS31
ILAHDEHMAQQDPGL	KIAA2013	576	Q8IYS2