Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	helicase activity	DDX42 WRN CHD3 DICER1 DHX35 DHX34	1.15e-04	158	96	6	GO:0004386
GeneOntologyMolecularFunction	ATP-dependent activity	WAPL MYO7B DDX42 WRN CHD3 DICER1 SMPDL3A DHX35 KIF13A DHX34 DNAH11	1.76e-04	614	96	11	GO:0140657
GeneOntologyMolecularFunction	clathrin light chain binding	CLTCL1 CALY	4.73e-04	7	96	2	GO:0032051
GeneOntologyMolecularFunction	MutLalpha complex binding	ATR WRN	4.73e-04	7	96	2	GO:0032405
GeneOntologyCellularComponent	symmetric, GABA-ergic, inhibitory synapse	NLGN4Y NLGN4X	1.27e-04	4	97	2	GO:0098983
GeneOntologyCellularComponent	neuron to neuron synapse	UNC13B NLGN4Y NECTIN3 DICER1 INSYN2A NLGN4X P2RX3 PURA SNX1 EPHA4	1.58e-04	523	97	10	GO:0098984
GeneOntologyCellularComponent	axonemal central apparatus	SPAG17 HYDIN	3.16e-04	6	97	2	GO:1990716
GeneOntologyCellularComponent	postsynaptic specialization	NLGN4Y NECTIN3 DICER1 INSYN2A NLGN4X PURA SNX1 EPHA4 GABRA3	5.52e-04	503	97	9	GO:0099572
Domain	Helicase_C	DDX42 WRN CHD3 DICER1 DHX35 DHX34	1.76e-05	107	95	6	PF00271
Domain	HELICc	DDX42 WRN CHD3 DICER1 DHX35 DHX34	1.76e-05	107	95	6	SM00490
Domain	Helicase_C	DDX42 WRN CHD3 DICER1 DHX35 DHX34	1.86e-05	108	95	6	IPR001650
Domain	HELICASE_CTER	DDX42 WRN CHD3 DICER1 DHX35 DHX34	1.96e-05	109	95	6	PS51194
Domain	HELICASE_ATP_BIND_1	DDX42 WRN CHD3 DICER1 DHX35 DHX34	1.96e-05	109	95	6	PS51192
Domain	DEXDc	DDX42 WRN CHD3 DICER1 DHX35 DHX34	1.96e-05	109	95	6	SM00487
Domain	Helicase_ATP-bd	DDX42 WRN CHD3 DICER1 DHX35 DHX34	2.07e-05	110	95	6	IPR014001
Domain	NLGN4	NLGN4Y NLGN4X	2.56e-05	2	95	2	IPR030025
Domain	DEAD/DEAH_box_helicase_dom	DDX42 WRN DICER1 DHX35 DHX34	3.50e-05	73	95	5	IPR011545
Domain	DEAD	DDX42 WRN DICER1 DHX35 DHX34	3.50e-05	73	95	5	PF00270
Domain	DEAH_ATP_HELICASE	WRN CHD3 DHX35 DHX34	4.06e-05	38	95	4	PS00690
Domain	Nlgn	NLGN4Y NLGN4X	2.53e-04	5	95	2	IPR000460
Domain	FAT	ATR TRRAP	3.79e-04	6	95	2	PS51189
Domain	FATC	ATR TRRAP	3.79e-04	6	95	2	PS51190
Domain	FAT	ATR TRRAP	3.79e-04	6	95	2	PF02259
Domain	PIK-rel_kinase_FAT	ATR TRRAP	3.79e-04	6	95	2	IPR003151
Domain	FATC_dom	ATR TRRAP	3.79e-04	6	95	2	IPR003152
Domain	PIK_FAT	ATR TRRAP	3.79e-04	6	95	2	IPR014009
Domain	FATC	ATR TRRAP	3.79e-04	6	95	2	SM01343
Domain	-	INSR NECTIN3 F13A1 CD84 PTPRG LSAMP SLAMF7 KIR3DL2 NFAT5 USH2A EPHA4	5.41e-04	663	95	11	2.60.40.10
Domain	DNA/RNA_helicase_DEAH_CS	CHD3 DHX35 DHX34	7.42e-04	35	95	3	IPR002464
Domain	Ig-like_fold	INSR NECTIN3 F13A1 CD84 PTPRG LSAMP SLAMF7 KIR3DL2 NFAT5 USH2A EPHA4	9.08e-04	706	95	11	IPR013783
Domain	Carboxylesterase_B_CS	NLGN4Y NLGN4X	1.93e-03	13	95	2	IPR019819
Domain	CARBOXYLESTERASE_B_2	NLGN4Y NLGN4X	2.24e-03	14	95	2	PS00941
Domain	COesterase	NLGN4Y NLGN4X	2.24e-03	14	95	2	PF00135
Domain	CarbesteraseB	NLGN4Y NLGN4X	2.24e-03	14	95	2	IPR002018
Domain	-	ATR TRRAP	2.93e-03	16	95	2	1.10.1070.11
Domain	PI3Kc	ATR TRRAP	2.93e-03	16	95	2	SM00146
Domain	DUF1605	DHX35 DHX34	3.31e-03	17	95	2	IPR011709
Domain	OB_NTP_bind	DHX35 DHX34	3.31e-03	17	95	2	PF07717
Domain	PI3_PI4_kinase	ATR TRRAP	3.71e-03	18	95	2	PF00454
Domain	PI3_4_KINASE_1	ATR TRRAP	3.71e-03	18	95	2	PS00915
Domain	PI3_4_KINASE_2	ATR TRRAP	3.71e-03	18	95	2	PS00916
Domain	PI3/4_kinase_cat_dom	ATR TRRAP	3.71e-03	18	95	2	IPR000403
Domain	HA2	DHX35 DHX34	3.71e-03	18	95	2	SM00847
Domain	PI3_4_KINASE_3	ATR TRRAP	3.71e-03	18	95	2	PS50290
Domain	HA2	DHX35 DHX34	3.71e-03	18	95	2	PF04408
Domain	Helicase-assoc_dom	DHX35 DHX34	3.71e-03	18	95	2	IPR007502
Domain	P-loop_NTPase	SAMD9 MYO7B DDX42 WRN CHD3 DICER1 DHX35 KIF13A DHX34 HYDIN DNAH11	3.82e-03	848	95	11	IPR027417
Domain	-	SAMD9 MYO7B DDX42 WRN CHD3 DICER1 DHX35 DHX34 HYDIN DNAH11	4.62e-03	746	95	10	3.40.50.300
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DIP2B DMXL2 WAPL SAMD9 ATR CHD3 NOL9 DICER1 FREM2 GTF2F1 DHX34	2.08e-06	650	97	11	38777146
Pubmed	Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle.	ATR WRN	7.70e-06	2	97	2	12629512
Pubmed	Unusually rapid evolution of Neuroligin-4 in mice.	NLGN4Y NLGN4X	7.70e-06	2	97	2	18434543
Pubmed	Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism.	NLGN4Y NLGN4X	7.70e-06	2	97	2	23183221
Pubmed	Juvenile manifestation of ultrasound communication deficits in the neuroligin-4 null mutant mouse model of autism.	NLGN4Y NLGN4X	7.70e-06	2	97	2	24855039
Pubmed	Sex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder.	NLGN4Y NLGN4X	7.70e-06	2	97	2	37001827
Pubmed	Increased Network Inhibition in the Dentate Gyrus of Adult Neuroligin-4 Knock-Out Mice.	NLGN4Y NLGN4X	7.70e-06	2	97	2	37080762
Pubmed	Autism Related Neuroligin-4 Knockout Impairs Intracortical Processing but not Sensory Inputs in Mouse Barrel Cortex.	NLGN4Y NLGN4X	7.70e-06	2	97	2	29106499
Pubmed	Tonicity-responsive microRNAs contribute to the maximal induction of osmoregulatory transcription factor OREBP in response to high-NaCl hypertonicity.	DICER1 NFAT5	7.70e-06	2	97	2	20852262
Pubmed	Perturbed Hippocampal Synaptic Inhibition and γ-Oscillations in a Neuroligin-4 Knockout Mouse Model of Autism.	NLGN4Y NLGN4X	7.70e-06	2	97	2	26456829
Pubmed	Nlgn4 knockout induces network hypo-excitability in juvenile mouse somatosensory cortex in vitro.	NLGN4Y NLGN4X	7.70e-06	2	97	2	24104404
Pubmed	A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y.	NLGN4Y NLGN4X	7.70e-06	2	97	2	32243781
Pubmed	Role of microRNA processing in adipose tissue in stress defense and longevity.	INSR DICER1	7.70e-06	2	97	2	22958919
Pubmed	Identification of a novel human member of the DEAD box protein family.	DDX42 DICER1	7.70e-06	2	97	2	10727850
Pubmed	Absence of deficits in social behaviors and ultrasonic vocalizations in later generations of mice lacking neuroligin4.	NLGN4Y NLGN4X	7.70e-06	2	97	2	22989184
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	CPN2 F13A1 FGL2 FREM2 FAT2 PTPRG C1R	8.09e-06	257	97	7	16335952
Pubmed	WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes.	ATR WRN	2.31e-05	3	97	2	22159421
Pubmed	HIV-1 infection increases microRNAs that inhibit Dicer1, HRB and HIV-EP2, thereby reducing viral replication.	HIVEP2 DICER1	2.31e-05	3	97	2	30682089
Pubmed	Evolution of the Autism-Associated Neuroligin-4 Gene Reveals Broad Erosion of Pseudoautosomal Regions in Rodents.	NLGN4Y NLGN4X	2.31e-05	3	97	2	32011705
Pubmed	Distinct proteins encoded by alternative transcripts of the PURG gene, located contrapodal to WRN on chromosome 8, determined by differential termination/polyadenylation.	WRN PURA	2.31e-05	3	97	2	12034829
Pubmed	Analysis of the neuroligin 4Y gene in patients with autism.	NLGN4Y NLGN4X	2.31e-05	3	97	2	18628683
Pubmed	Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.	NLGN4Y NLGN4X	2.31e-05	3	97	2	21282647
Pubmed	Clustering of Genetic Anomalies of Cilia Outer Dynein Arm and Central Apparatus in Patients with Transposition of the Great Arteries.	HYDIN DNAH11	4.60e-05	4	97	2	36140829
Pubmed	Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.	NLGN4Y NLGN4X	4.60e-05	4	97	2	12669065
Pubmed	Homodimerization and isoform-specific heterodimerization of neuroligins.	NLGN4Y NLGN4X	4.60e-05	4	97	2	22671294
Pubmed	Ultrasonic vocalizations in mouse models for speech and socio-cognitive disorders: insights into the evolution of vocal communication.	NLGN4Y NLGN4X	4.60e-05	4	97	2	20579107
Pubmed	Analysis of four neuroligin genes as candidates for autism.	NLGN4Y NLGN4X	4.60e-05	4	97	2	16077734
Pubmed	Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations.	NLGN4Y NLGN4X	4.60e-05	4	97	2	17292328
Pubmed	Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action.	INSR IKBKB	4.60e-05	4	97	2	11606564
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	DDX42 CHD3 TRRAP GTF2F1 EIF2A DHX34	7.43e-05	250	97	6	33536335
Pubmed	TAK1 is a ubiquitin-dependent kinase of MKK and IKK.	TAB2 IKBKB	7.66e-05	5	97	2	11460167
Pubmed	The many substrates and functions of ATM.	ATR WRN	7.66e-05	5	97	2	11252893
Pubmed	IKK/NF-kappaB signaling pathway inhibits cell-cycle progression by a novel Rb-independent suppression system for E2F transcription factors.	TRRAP IKBKB	7.66e-05	5	97	2	18542057
Pubmed	Neuroligins and neurexins link synaptic function to cognitive disease.	NLGN4Y NLGN4X	7.66e-05	5	97	2	18923512
Pubmed	Synapse formation: if it looks like a duck and quacks like a duck ...	NLGN4Y NLGN4X	7.66e-05	5	97	2	10996085
Pubmed	Multiple N-linked glycosylation sites critically modulate the synaptic abundance of neuroligin isoforms.	NLGN4Y NLGN4X	7.66e-05	5	97	2	37865312
Pubmed	The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease?	NLGN4Y NLGN4X	1.15e-04	6	97	2	21838267
Pubmed	Autism-associated neuroligin-4 mutation selectively impairs glycinergic synaptic transmission in mouse brainstem synapses.	NLGN4Y NLGN4X	1.15e-04	6	97	2	29724786
Pubmed	USP19 Inhibits TNF-α- and IL-1β-Triggered NF-κB Activation by Deubiquitinating TAK1.	TAB2 IKBKB	1.15e-04	6	97	2	31127032
Pubmed	Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein.	TAB2 IKBKB	1.15e-04	6	97	2	18682563
Pubmed	TRIM25 Promotes TNF-α-Induced NF-κB Activation through Potentiating the K63-Linked Ubiquitination of TRAF2.	TAB2 IKBKB	1.15e-04	6	97	2	32024699
Pubmed	Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase.	TAB2 IKBKB	1.15e-04	6	97	2	18180283
Pubmed	Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest.	ATR WRN	1.15e-04	6	97	2	17118963
Pubmed	Effects of constitutively active IKKβ on cardiac development.	MYOCD IKBKB	1.15e-04	6	97	2	35597154
Pubmed	PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination.	TAB2 IKBKB	1.15e-04	6	97	2	19150425
Pubmed	Induction of a pro-apoptotic ATM-NF-kappaB pathway and its repression by ATR in response to replication stress.	ATR IKBKB	1.15e-04	6	97	2	18583959
Pubmed	SAP-Dependent and -Independent Regulation of Innate T Cell Development Involving SLAMF Receptors.	CD84 SLAMF7	1.15e-04	6	97	2	24795728
Pubmed	Immune cells control skin lymphatic electrolyte homeostasis and blood pressure.	INSR NFAT5	1.60e-04	7	97	2	23722907
Pubmed	Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death.	TAB2 IKBKB	1.60e-04	7	97	2	9744859
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	WAPL RPN1 TUBGCP5 TRRAP DICER1 DHX35	2.01e-04	300	97	6	28561026
Pubmed	Placentation defects are highly prevalent in embryonic lethal mouse mutants.	DMXL2 SQLE DDX42 DHX35	2.03e-04	103	97	4	29539633
Pubmed	CHIP promotes the activation of NF-κB signaling through enhancing the K63-linked ubiquitination of TAK1.	TAB2 IKBKB	2.13e-04	8	97	2	34535633
Pubmed	Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways.	NLGN4Y NLGN4X	2.13e-04	8	97	2	30871858
Pubmed	The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2).	CD84 SLAMF7	2.13e-04	8	97	2	12621057
Pubmed	Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus.	CD84 SLAMF7	2.13e-04	8	97	2	15589166
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	WAPL DDX42 ZDBF2 NECTIN3 DICER1 GTF2F1 ALMS1 POC5 SKA3	2.14e-04	733	97	9	34672954
Pubmed	High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.	DDX42 ZNF217 FREM2 PTPRG DENND6B DHX34	2.27e-04	307	97	6	37499664
Pubmed	Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development.	ME1 ITIH5 GTF2F1 NFAT5 EPHA4	2.29e-04	196	97	5	19334288
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DIP2B HIVEP2 NLGN4Y INSR CHD3 VPS54 TRRAP CASZ1 PTPRG TECPR2 PURA NFAT5 VPS13B	2.53e-04	1489	97	13	28611215
Pubmed	Identification of a family of sorting nexin molecules and characterization of their association with receptors.	INSR SNX1	2.74e-04	9	97	2	9819414
Pubmed	Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor.	MYOCD EPHA4	2.74e-04	9	97	2	21423180
Pubmed	Using mouse models of autism spectrum disorders to study the neurotoxicology of gene-environment interactions.	NLGN4Y NLGN4X	2.74e-04	9	97	2	23010509
Pubmed	Microglia ablation alleviates myelin-associated catatonic signs in mice.	NLGN4Y NLGN4X	2.74e-04	9	97	2	29252214
Pubmed	Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO.	TAB2 IKBKB	2.74e-04	9	97	2	16603398
Pubmed	LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO.	TAB2 IKBKB	2.74e-04	9	97	2	21811235
Pubmed	Soluble SORLA Enhances Neurite Outgrowth and Regeneration through Activation of the EGF Receptor/ERK Signaling Axis.	INSR EPHA4	2.74e-04	9	97	2	32601248
Pubmed	Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion.	WAPL PAX5	2.74e-04	9	97	2	32612238
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	WAPL CASP14 TRRAP DICER1 SNX1	3.28e-04	212	97	5	33853758
Pubmed	HIV-1 Vpr stimulates NF-κB and AP-1 signaling by activating TAK1.	TAB2 IKBKB	3.41e-04	10	97	2	24912525
Pubmed	Tel2 regulates the stability of PI3K-related protein kinases.	ATR TRRAP	3.41e-04	10	97	2	18160036
Pubmed	PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome.	TAB2 ALMS1 SKA3	3.53e-04	49	97	3	31762063
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	CLTCL1 ZDBF2 ZNF217 NOL9 TRRAP GTF2F1	3.85e-04	339	97	6	30415952
Pubmed	A secreted protein microarray platform for extracellular protein interaction discovery.	NECTIN3 LSAMP SLAMF7	3.97e-04	51	97	3	21982860
Pubmed	Regulation and function of IKK and IKK-related kinases.	TAB2 IKBKB	4.17e-04	11	97	2	17047224
Pubmed	The germinal center kinase TNIK is required for canonical NF-κB and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor.	TAB2 IKBKB	4.17e-04	11	97	2	22904686
Pubmed	Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.	ATR TRRAP	4.17e-04	11	97	2	20427287
Pubmed	USP10 inhibits genotoxic NF-κB activation by MCPIP1-facilitated deubiquitination of NEMO.	TAB2 IKBKB	4.17e-04	11	97	2	24270572
Pubmed	The p38-interacting protein p38IP suppresses TCR and LPS signaling by targeting TAK1.	TAB2 IKBKB	4.17e-04	11	97	2	32410369
Pubmed	Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma.	TRRAP USH2A	4.17e-04	11	97	2	24349473
Pubmed	MALT1-ubiquitination triggers non-genomic NF-κB/IKK signaling upon platelet activation.	TAB2 IKBKB	4.17e-04	11	97	2	25748427
Pubmed	SPARCL1 Promotes Excitatory But Not Inhibitory Synapse Formation and Function Independent of Neurexins and Neuroligins.	NLGN4Y NLGN4X	4.17e-04	11	97	2	32973045
Pubmed	Behavioral phenotypes of genetic mouse models of autism.	NLGN4Y NLGN4X	4.17e-04	11	97	2	26403076
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DMXL2 TUBGCP5 SLC7A14 CASZ1 FAT2 ALMS1 MEX3B	4.72e-04	493	97	7	15368895
Pubmed	Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.	TAB2 IKBKB	4.99e-04	12	97	2	19136968
Pubmed	Lessons on conditional gene targeting in mouse adipose tissue.	INSR DICER1	4.99e-04	12	97	2	23321074
Pubmed	Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells.	IKBKB NFAT5	4.99e-04	12	97	2	15790681
Pubmed	TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.	TAB2 IKBKB	4.99e-04	12	97	2	16260493
Pubmed	Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.	ATR DICER1 SLC7A14 ALMS1 USH2A	5.05e-04	233	97	5	32290105
Pubmed	Advancing the understanding of autism disease mechanisms through genetics.	NLGN4Y NLGN4X	5.89e-04	13	97	2	27050589
Pubmed	Disruption of the cereblon gene enhances hepatic AMPK activity and prevents high-fat diet-induced obesity and insulin resistance in mice.	INSR DICER1	5.89e-04	13	97	2	23349485
Pubmed	Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.	CPN2 F13A1 C1R EIF2A	7.06e-04	143	97	4	22516433
Pubmed	Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.	RAP1GAP2 TUBGCP5 ALMS1 POC5	7.63e-04	146	97	4	21399614
Pubmed	Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains.	TAB2 IKBKB	7.89e-04	15	97	2	23986494
Pubmed	Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism.	NLGN4Y NLGN4X	7.89e-04	15	97	2	18227507
Pubmed	Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction.	TAB2 IKBKB	7.89e-04	15	97	2	20005846
Pubmed	Conditional Dicer1 depletion using Chrnb4-Cre leads to cone cell death and impaired photopic vision.	DICER1 ARR3	7.89e-04	15	97	2	30783126
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	WAPL DDX42 TAB2 CHD3 NOL9 F13A1 KIF13A NFAT5 VPS13B ZNF445	9.01e-04	1084	97	10	11544199
Pubmed	Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases.	INSR SNX1	9.01e-04	16	97	2	11279102
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	WAPL DDX42 CHD3 ZNF217 CASZ1	9.47e-04	268	97	5	33640491
Pubmed	Analysis of Ku70 S155 Phospho-Specific BioID2 Interactome Identifies Ku Association with TRIP12 in Response to DNA Damage.	WAPL DDX42 CHD3 GTF2F1	9.76e-04	156	97	4	37108203
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HGABA	DIP2B RAP1GAP2 CHD3 DICER1 SLC7A14 CASZ1 INSYN2A CREBRF FAT2 NLGN4X LSAMP PAX5 SPAG17 KIF13A HYDIN SNX1	2.51e-06	1106	96	16	M39071
Coexpression	GSE6092_UNSTIM_VS_IFNG_STIM_ENDOTHELIAL_CELL_DN	INSR WRN TAB2 VPS54 CD84 USP48 VPS13B	8.81e-06	199	96	7	M6711
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	DMXL2 WAPL HIVEP2 ATR DDX42 WRN TAB2 NECTIN3 TRRAP MBOAT2 DICER1 VPS13B EPHA4	1.45e-05	856	96	13	M4500
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO7B FREM2 MYOCD SPAG17 USH2A HYDIN DNAH11	1.50e-07	184	96	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO7B FREM2 MYOCD SPAG17 USH2A HYDIN DNAH11	1.50e-07	184	96	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO7B FREM2 MYOCD SPAG17 USH2A HYDIN DNAH11	1.50e-07	184	96	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	(2)_NK/T-(210)_NKT_cell\|(2)_NK/T / immune cells in Peripheral Blood (logTPM normalization)	TRPC3 SQLE MBOAT2 FGL2 SMPDL3A PAX5	3.44e-06	189	96	6	fa72e87e1e8cd7cbddae7b47e19cf90d181820a7
ToppCell	(2)_NK/T-(21)_NKT_cell\|(2)_NK/T / immune cells in Peripheral Blood (logTPM normalization)	TRPC3 SQLE MBOAT2 FGL2 SMPDL3A PAX5	3.44e-06	189	96	6	b37ad24898a14a4a3b2d6cea2637de2471f76e20
ToppCell	tumor_Lymph_Node_/_Brain-B_lymphocytes-MALT_B_cells\|B_lymphocytes / Location, Cell class and cell subclass	RPN1 INSR RCBTB2 ALG5 C1R SLAMF7	3.54e-06	190	96	6	ce70336679a2b713836e7497e6dc48aac612b018
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	UNC13B SQLE FREM2 SPAG17 HYDIN DNAH11	3.88e-06	193	96	6	bdb7401dd9059032f930f2b575f2ef8e504b6594
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD8-Trm/em_CD8\|GI_small-bowel / Manually curated celltypes from each tissue	RAP1GAP2 STK31 ITIH5 TEX48 EPHA4	1.51e-05	144	96	5	a4bb274d553c29c8299354de757ecc5634008c68
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO7B PTPRG MYOCD USH2A HYDIN	2.52e-05	160	96	5	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO7B PTPRG MYOCD USH2A HYDIN	2.52e-05	160	96	5	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	343B-Myeloid-Dendritic-cDC_proliferating_2\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	UNC13B DMXL2 PRSS57 NOL9 SMPDL3A	2.83e-05	164	96	5	d7053de88ef8e42cac6726a40e72f212659ee034
ToppCell	PND14-Immune-Immune_Myeloid-Dendritic\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PRSS57 FGL2 DHX35 SKA3 SLAMF7	3.18e-05	168	96	5	9b8a74abb83c64f0b5829dcb4275f722c82b45dc
ToppCell	droplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HIVEP2 TRAPPC5 HEMGN FGL2 SLAMF7	3.18e-05	168	96	5	99148986aa5628f67d85258c171b254be77a071c
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NLGN4Y HEMGN SPAG17 HYDIN DNAH11	3.18e-05	168	96	5	9a8709d34865cfa668d8f3335dc34fc86fc32482
ToppCell	PND14-Immune-Immune_Myeloid-Dendritic-cDC1\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PRSS57 FGL2 DHX35 SKA3 SLAMF7	3.18e-05	168	96	5	4b152b8d0f4a66faf664dfacb7914b18d60ce64a
ToppCell	PND14-Immune-Immune_Myeloid-Dendritic-cDC1-cDC1_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PRSS57 FGL2 DHX35 SKA3 SLAMF7	3.18e-05	168	96	5	c3169ad8f4130ef18777ed86770bb722ffb5db85
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MUC16 WDR93 SPAG17 HYDIN DNAH11	3.27e-05	169	96	5	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	facs-Lung-nan-3m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B TUBGCP5 ME1 FGL2 PTPRG	3.36e-05	170	96	5	8e1f757ed62218c0fb6525f49d142dd2cd29acf9
ToppCell	COVID-19-Heart-CM_+_Macrophage\|Heart / Disease (COVID-19 only), tissue and cell type	DMXL2 ME1 F13A1 CD84 MYOCD	3.36e-05	170	96	5	4232fe937909f93d3736988c707b8f95ce993398
ToppCell	droplet-Lung-nan-18m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIVEP2 TRAPPC5 SQLE FGL2 SLAMF7	3.36e-05	170	96	5	545c755b057871b7a22221a049a63a61713dad1d
ToppCell	facs-Lung-nan-3m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B TUBGCP5 ME1 FGL2 PTPRG	3.36e-05	170	96	5	67d7e1da3ebd2d14cb2e67799e94d655027ed5c4
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Myeloid-cDC1\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FGL2 CD84 FAT2 SPAG17 MEX3B	3.65e-05	173	96	5	d13ae4046a25ee0fb492ddedf44583a879a432e9
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Myeloid-Lymphoid_DC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRSS57 NLGN4Y INSYN2A CD84 DNAH11	3.76e-05	174	96	5	16204ff504b7b382b4d90ca35003ad5336020e07
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRPC3 ITIH5 SPAG17 HYDIN DNAH11	3.86e-05	175	96	5	284fdc7a9d303636a637041846850d19d114861a
ToppCell	LPS_only-Myeloid-Monocytes,_Macrophages-Monocytes-Macrophages\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DMXL2 RAP1GAP2 F13A1 FGL2 SMPDL3A	4.30e-05	179	96	5	dc03b9045510eb1bb934329646bb92dd06890ce9
ToppCell	LPS_only-Myeloid-Monocytes,_Macrophages\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DMXL2 RAP1GAP2 F13A1 FGL2 SMPDL3A	4.30e-05	179	96	5	330c1326ba93bb8f32559ee1cc40e357cc44ad8d
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	WDR93 DENND6B SPAG17 HYDIN DNAH11	4.41e-05	180	96	5	92fb01b91261b3103454924cde56add337b41844
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-fibroblastic-mLTo\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ME1 ITIH5 NLGN4X C1R LSAMP	4.41e-05	180	96	5	d1c52aeceb3627e3c5fb6cc3af77e0400f9380ab
ToppCell	LPS-antiTNF-Epithelial_alveolar-Mes-Like-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNIP5 TRPC3 P2RX3 HYDIN	4.51e-05	91	96	4	b0658e020f80e56fab9d2aa07e321d9b33d7af2c
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO7B WDR93 SPAG17 JHY DNAH11	4.77e-05	183	96	5	6ca7c2d7c56e0f1b9038ba677b4c1c3dfd63bfce
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO7B WDR93 SPAG17 JHY DNAH11	4.77e-05	183	96	5	18040d0653286071df959513c63d94b555a5d00a
ToppCell	Ciliated_cells-B-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	MUC16 WDR93 SPAG17 HYDIN DNAH11	5.03e-05	185	96	5	f012c243343e1d1956db19b34d062e9b13de2b2a
ToppCell	LA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	CLTCL1 RAP1GAP2 CASZ1 MYOCD EPHA4	5.43e-05	188	96	5	6d249fe92d51a19da19ec14bb2262d394255d577
ToppCell	cellseq2-Epithelial-Epithelial_Airway\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CYP4B1 WDR93 SPAG17 HYDIN DNAH11	5.70e-05	190	96	5	17829f4de31b3d9e4d71ba4817d18842aa699773
ToppCell	BAL-Control-Epithelial-Epithelial-Ciliated\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	CYP4B1 MUC16 SPAG17 HYDIN DNAH11	5.85e-05	191	96	5	7b5da29109aa28768c67653a1bc0f385c2d2269b
ToppCell	BAL-Control-Epithelial\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	CYP4B1 MUC16 SPAG17 HYDIN DNAH11	5.85e-05	191	96	5	9f19098f260d5542aa8ba7eb6f91b44d0db6e0a4
ToppCell	BAL-Control-Epithelial-Epithelial-Ciliated-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CYP4B1 MUC16 SPAG17 HYDIN DNAH11	5.85e-05	191	96	5	fa9f8b50bfc7911c858bc2f9dcd204873d97ac61
ToppCell	Control-Epithelial-Ciliated_cells\|Control / Condition, Lineage and Cell class	CYP4B1 MUC16 SPAG17 HYDIN DNAH11	5.85e-05	191	96	5	ea1d2c6838119b7019e9a2ff71d6212262b51b57
ToppCell	Healthy_Control-Epithelial-Epithelial-\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	CYP4B1 MUC16 WDR93 SPAG17 HYDIN	5.85e-05	191	96	5	28caedb2e448e0c7f494100d714fa7cdcf150691
ToppCell	BAL-Control-Epithelial-Epithelial-Ciliated-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CYP4B1 MUC16 SPAG17 HYDIN DNAH11	5.85e-05	191	96	5	b4e335e798c9617356b8e24412f9270c42dce656
ToppCell	BAL-Control-Epithelial-Epithelial-Ciliated\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CYP4B1 MUC16 SPAG17 HYDIN DNAH11	5.85e-05	191	96	5	c4b223b33c020a064f576711a3d700eb60a2d737
ToppCell	BAL-Control-Epithelial\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CYP4B1 MUC16 SPAG17 HYDIN DNAH11	5.85e-05	191	96	5	5129f778a9283bfac4ff322c21c5ca71da4b7174
ToppCell	BAL-Control-Epithelial-Epithelial\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	CYP4B1 MUC16 SPAG17 HYDIN DNAH11	5.85e-05	191	96	5	df8a1a6e78aa0cb941b94cb676bd6891d79f3687
ToppCell	Healthy_Control-Epithelial-Epithelial\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	CYP4B1 MUC16 WDR93 SPAG17 HYDIN	5.85e-05	191	96	5	15b9386b26caaa7d15f704c4a18881e1ce918a21
ToppCell	Control-Epithelial\|Control / Disease group,lineage and cell class （2021.01.30）	CYP4B1 MUC16 SPAG17 HYDIN DNAH11	5.85e-05	191	96	5	b78547dae8328244a47c83346447bdd787efbcae
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-MUC16+_ciliated\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CYP4B1 MUC16 SPAG17 HYDIN DNAH11	5.85e-05	191	96	5	e81cd65dbf0ef1c2ab7088f73ce605d456dd3a7a
ToppCell	Healthy_Control-Epithelial\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	CYP4B1 MUC16 WDR93 SPAG17 HYDIN	5.85e-05	191	96	5	fdcdadbfc9ccae175abe4de8c7428ac4f6a67fde
ToppCell	BAL-Control-Epithelial-Epithelial\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CYP4B1 MUC16 SPAG17 HYDIN DNAH11	5.85e-05	191	96	5	c50d6a1a6209ed4157f7c00fc24d4ecb43790f44
ToppCell	Control-Epithelial-Ciliated\|Control / Disease group,lineage and cell class （2021.01.30）	CYP4B1 MUC16 SPAG17 HYDIN DNAH11	5.85e-05	191	96	5	cdc08e95a0c8f5c7a8d01b6bbaafdb54ef2f0d12
ToppCell	Control-Epithelial\|Control / Condition, Lineage and Cell class	CYP4B1 MUC16 SPAG17 HYDIN DNAH11	5.85e-05	191	96	5	6228302febdb3dffe37dece7062d27ac9ccc6d4b
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SQLE NECTIN3 MBOAT2 SLC7A14 USH2A	5.99e-05	192	96	5	5b7093d5af5ae7b0e6d3a464cc56272440ecedad
ToppCell	renal_papilla_nuclei-Adult_normal_reference\|renal_papilla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	ME1 ITIH5 FGL2 LSAMP EPHA4	5.99e-05	192	96	5	6c106b91e46eabbe686a52a65a9c94ad9cbe9390
ToppCell	15-Trachea-Epithelial-Intermediate_ciliated\|Trachea / Age, Tissue, Lineage and Cell class	MUC16 DENND6B SPAG17 HYDIN DNAH11	5.99e-05	192	96	5	9cbe961a800c981cdc742a47ed18e9c8eb6430bd
ToppCell	Children_(3_yrs)-Immune-monocyte-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DMXL2 RAP1GAP2 RCBTB2 F13A1 FGL2	6.14e-05	193	96	5	58e1930a1d80ad3729ab9604ac8ebf7308232a3d
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)\|Adult / Lineage, Cell type, age group and donor	DMXL2 RCBTB2 ME1 F13A1 CD84	6.14e-05	193	96	5	31c0978ba78c9516d498aec0798902e57555e557
ToppCell	CF-Lymphoid\|CF / Disease state, Lineage and Cell class	SCFD2 ATR WRN PAX5 USP48	6.14e-05	193	96	5	11de07d13a7da223990b56fa89ba7fc1c3dd0122
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-MUC16+_ciliated\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CYP4B1 MUC16 SPAG17 HYDIN DNAH11	6.30e-05	194	96	5	756082a0f5953b52229bb60d40b84701cb6cb23d
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SCFD2 TRPC3 NECTIN3 PTPRG LSAMP	6.30e-05	194	96	5	b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCell	Monocytes-C1QA+_Monocytes\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	DMXL2 ME1 F13A1 FGL2 CD84	6.30e-05	194	96	5	3e104e85574894c04791252d466d438fc809dde3
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)-D231\|Adult / Lineage, Cell type, age group and donor	DMXL2 RCBTB2 ME1 F13A1 CD84	6.30e-05	194	96	5	800d3d7a9e864d2d6a100a4e4af22f45d5790a8d
ToppCell	COVID-19-Epithelial-Ciliated_cells\|COVID-19 / Condition, Lineage and Cell class	CYP4B1 MUC16 SPAG17 HYDIN DNAH11	6.30e-05	194	96	5	43be5fbd51dd58839cb03ca3ddd05a458e1ddb74
ToppCell	Control-Myeloid-ncMonocyte\|World / Disease state, Lineage and Cell class	DMXL2 INSR RAP1GAP2 FGL2 NFAT5	6.45e-05	195	96	5	b4444b67a709e82b8e2ee510924c3152cb88b051
ToppCell	COPD-Multiplet-Multiplet\|COPD / Disease state, Lineage and Cell class	CYP4B1 PTPRG SPAG17 HYDIN DNAH11	6.61e-05	196	96	5	af4cdc61830685a888a1209826c23bcf54a43084
ToppCell	COPD-Multiplet\|COPD / Disease state, Lineage and Cell class	CYP4B1 PTPRG SPAG17 HYDIN DNAH11	6.61e-05	196	96	5	6d02d494196e3f857d53eea46d9419690d43beca
ToppCell	PCW_10-12\|World / Celltypes from embryonic and fetal-stage human lung	HIVEP2 NLGN4Y ITIH5 CREBRF NFAT5	6.77e-05	197	96	5	47fd8b0d596c5db1a722473c8efbb17a6bbe7538
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	WDR93 SKA3 SPAG17 HYDIN DNAH11	6.77e-05	197	96	5	6e4a411ef823ce9e16f420e185e21fa19d13af34
ToppCell	COVID-19-Epithelial\|COVID-19 / Condition, Lineage and Cell class	CYP4B1 MUC16 SPAG17 HYDIN DNAH11	6.77e-05	197	96	5	18fd7344628a87d5c7ef5efb66e260a4136245bf
ToppCell	BAL-Mild-Epithelial-Epithelial\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CYP4B1 MUC16 SPAG17 HYDIN DNAH11	7.10e-05	199	96	5	1ee4010d8557564e25e8ee00b914c2dfd9037838
ToppCell	BAL-Mild-Epithelial-Epithelial\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	CYP4B1 MUC16 SPAG17 HYDIN DNAH11	7.10e-05	199	96	5	1df69c0cb5f759f6a2152521842506a75bb95cae
ToppCell	Mild-Epithelial-Epithelial-\|Mild / Condition, Lineage, Cell class and cell subclass	CYP4B1 MUC16 SPAG17 HYDIN DNAH11	7.10e-05	199	96	5	81115bbd2c10bfdd38376d2075f03a59c31870d2
ToppCell	BAL-Mild-Epithelial\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CYP4B1 MUC16 SPAG17 HYDIN DNAH11	7.10e-05	199	96	5	74087b4b5e567310fc4ac58fb267ff651a180680
ToppCell	BAL-Mild-Epithelial\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	CYP4B1 MUC16 SPAG17 HYDIN DNAH11	7.10e-05	199	96	5	00b5ce099c50a5e1786ce2b3a06ee0931a8205a4
ToppCell	Mild-Epithelial\|Mild / Condition, Lineage, Cell class and cell subclass	CYP4B1 MUC16 SPAG17 HYDIN DNAH11	7.10e-05	199	96	5	ec5fff80e2a8a94fbaf1fdcc6d45c8d7c6252e18
ToppCell	Mild-Epithelial-Epithelial\|Mild / Condition, Lineage, Cell class and cell subclass	CYP4B1 MUC16 SPAG17 HYDIN DNAH11	7.10e-05	199	96	5	91308b255783ad4029e5575028c18d7550832c51
ToppCell	Mild_COVID-19-Epithelial\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	CYP4B1 MUC16 SPAG17 HYDIN DNAH11	7.10e-05	199	96	5	72689bda7476930887ae007682fcab27f956f050
ToppCell	Lung_Parenchyma-Severe\|Lung_Parenchyma / Location, Disease Group, Cell group, Cell class (2021.03.09)	MUC16 CD84 SMPDL3A C1R SLAMF7	7.27e-05	200	96	5	62502bb23ca732daed32c838ce9719093f3aaeb0
ToppCell	Parenchymal-10x5prime-Immune_Myeloid-Macrophage_other-Macrophage_intravascular\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DMXL2 F13A1 FGL2 CD84 SMPDL3A	7.27e-05	200	96	5	77a68e8fd97a3f3467d25032067fd7ad52ab8522
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD11d\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PRSS57 RAP1GAP2 ZDBF2 SLAMF7 KIR3DL2	7.27e-05	200	96	5	eda7a1d822e8663510662bc0ca34eaccc88d71ca
ToppCell	LPS-IL1RA+antiTNF-Myeloid-Dendritic_cells-Monocytes-Macrophages\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RAP1GAP2 FGL2 FAT2 SMPDL3A	2.80e-04	146	96	4	b76110b159acd27a2c8d6a9f98336608ace1ec12
ToppCell	LPS_only-Myeloid-Dendritic_cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYO7B FGL2 CD84 SLAMF7	2.95e-04	148	96	4	cb9365663f9cba35d47b5dd9079f42e88b70d915
ToppCell	COVID-19-Epithelial_cells-Airway_mucous\|COVID-19 / group, cell type (main and fine annotations)	MUC16 SPAG17 HYDIN DNAH11	3.19e-04	151	96	4	8216462e723fec2797387929dde095370947e10a
ToppCell	frontal_cortex\|World / Per Region, Lineage, Cell class, Cell type, Cell subtype	TRPC3 RCBTB2 CASZ1 LSAMP	3.27e-04	152	96	4	f9c29d4568402ca07a717dbffb3ccc7f35c5fe56
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP4B1 SQLE ALMS1 HYDIN	3.43e-04	154	96	4	ec56b7fb88e39041416c384f371c767f3b4e92fa
ToppCell	LPS_only-Epithelial_airway-Ciliated_cells-Ciliated\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SPAG17 USH2A HYDIN DNAH11	3.43e-04	154	96	4	9ca71d440c4f87781e6525b8141e7d8d470b6a8e
ToppCell	Control-PLT_4\|World / Disease Group and Platelet Clusters	ATR HEMGN CASZ1 CREBRF	3.43e-04	154	96	4	a2a03c5e6759c45aeeedf1e68ecb5a0112ef9a20
ToppCell	LPS_only-Epithelial_airway-Ciliated_cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SPAG17 USH2A HYDIN DNAH11	3.43e-04	154	96	4	58072ce422d09f2de602580325eaac6c4ec6c136
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	MUC16 WDR93 SPAG17 DNAH11	3.61e-04	156	96	4	10d191e29b16cae8238e8df6c0ff38882253f34e
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c4-RSAD2\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MYO7B SLC7A14 FGL2 DENND6B	3.61e-04	156	96	4	f5889a6899904dfb7f596600b3a76857cf9d5378
ToppCell	NS-moderate-d_07-13-Epithelial-FOXN4+\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ALMS1 SPAG17 HYDIN DNAH11	3.69e-04	157	96	4	410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCell	droplet-Bladder-nan-24m-Hematologic-macrophage\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	F13A1 FGL2 CD84 SLAMF7	3.78e-04	158	96	4	4a9d4706876f6e86fc5d63ad6dc7df1b4a5cfd9e
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	BNIP5 STK31 PTPRG DNAH11	3.87e-04	159	96	4	b1d5ebd0c186b6d0279dab20d8f3b4a915acdc1f
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK31 SPAG17 HYDIN DNAH11	3.87e-04	159	96	4	00a157d033627d0e65c3fbd38d652c4cf56b47f6
ToppCell	BAL-Mild-cDC_5\|Mild / Compartment, Disease Groups and Clusters	INSR MUC16 XYLT2 DHX34	4.06e-04	161	96	4	7a6e8ed0b5d999efce8945d8083ab01d71be9a92
ToppCell	367C-Lymphocytic-ILC-ILC-3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ME1 TECPR2 TRIM16L EPHA4	4.06e-04	161	96	4	8de421c61f4d5a6e05fdb20e4d230e2db98ee4d5
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-T_cells-TRGV2_gdT\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRSS57 TRPC3 RCBTB2 SLAMF7	4.26e-04	163	96	4	004765e016c5658ee4a8bda4899804303064727b
ToppCell	Healthy_Control-Lymphoid-Plasma\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	TUBGCP5 F13A1 SLAMF7 RWDD2A	4.26e-04	163	96	4	2913ccdd4613472cd82077d4993e1d9f8b223398
ToppCell	Healthy_Control-Lymphoid-Plasma-\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	TUBGCP5 F13A1 SLAMF7 RWDD2A	4.26e-04	163	96	4	b589ff57d58dcb215ee3b5a10d81f43e5752a196
ToppCell	droplet-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HIVEP2 TRAPPC5 SQLE SLAMF7	4.46e-04	165	96	4	1c630f9ecde2e0243922a2be4b1ab5adcfcb0893
ToppCell	15-Airway-Mesenchymal-Airway_Smooth_Muscle\|Airway / Age, Tissue, Lineage and Cell class	CASZ1 FGL2 MYOCD EPHA4	4.46e-04	165	96	4	531804467601e1ee1f771cffa21501f6d464ae10
ToppCell	droplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TRAPPC5 SQLE FGL2 SLAMF7	4.46e-04	165	96	4	479962ce1c3d6636ae62b6709635299748653801
Disease	stroke	RAP1GAP2 CHD3 CASZ1 FAT2 PTPRG	1.05e-04	144	95	5	EFO_0000712
Disease	entorhinal cortical volume	F13A1 EPHA4	1.53e-04	6	95	2	EFO_0005092
Disease	cognitive inhibition measurement	HIVEP2 RAP1GAP2 USH2A	5.68e-04	50	95	3	EFO_0007969
Disease	blood nickel measurement	MUC16 FAT2 KIF13A USH2A	6.23e-04	120	95	4	EFO_0007583
Disease	sensory peripheral neuropathy, response to platinum based chemotherapy	LSAMP MEX3B	7.82e-04	13	95	2	EFO_0004647, MONDO_0002321
Disease	platelet-derived growth factor BB measurement	ME1 LSAMP RWDD2A	1.02e-03	61	95	3	EFO_0008264
Disease	cataract	SCFD2 CASZ1 NFAT5 EPHA4	1.14e-03	141	95	4	MONDO_0005129
Disease	omega-3 polyunsaturated fatty acid measurement, diet measurement	ME1 RWDD2A	1.20e-03	16	95	2	EFO_0008111, EFO_0010119
Disease	Antihypertensive use measurement	DIP2B HIVEP2 INSR CASZ1 NFAT5	1.69e-03	265	95	5	EFO_0009927
Disease	stroke, major depressive disorder	PTPRG PAX5	1.69e-03	19	95	2	EFO_0000712, MONDO_0002009
Disease	prostate adenocarcinoma (is_implicated_in)	INSR IKBKB	1.88e-03	20	95	2	DOID:2526 (is_implicated_in)
Disease	depressive symptom measurement	PCDHA3 VPS54 PTPRG LSAMP PAX5 MEX3B	2.58e-03	426	95	6	EFO_0007006
Disease	neuroticism measurement	UNC13B VPS54 F13A1 NLGN4X PTPRG LSAMP PAX5 ARHGAP27 EPHA4	2.66e-03	909	95	9	EFO_0007660
Disease	Impaired glucose tolerance	INSR IKBKB	2.93e-03	25	95	2	C0271650
Disease	primary aldosteronism	DMXL2 CASZ1	3.17e-03	26	95	2	MONDO_0001422

Protein segments in the cluster

Peptide	Gene	Start	Entry
VTSTQVPPTATEEQY	PTPRG	671	P23470
DIPPYTKNIIFVETS	CPN2	46	P22792
PTDKPAVTEDVNIYQ	CASZ1	451	Q86V15
PYQDEEVISKTPTLA	CREBRF	126	Q8IUR6
DSPTKQLSVVVPSYN	ALG5	61	Q9Y673
IPAVQSSSYSQREKP	ALMS1	756	Q8TCU4
EIPAVQSSSYPQREK	ALMS1	1041	Q8TCU4
PVDRQETKQTYECPV	DNAH11	4466	Q96DT5
KIPQSYEDQTVSQPE	DMXL2	1451	Q8TDJ6
KQEIPVQPTTSYSIQ	DICER1	1206	Q9UPY3
FKEFTTRTQAPPNVV	DENND6B	316	Q8NEG7
KPYPNNFETTTVITV	C1R	36	P00736
YVQTLQVVPAESSSP	ARR3	76	P36575
NQSYPTPVTVEKDRI	RCBTB2	296	O95199
IEETQVIPSPYSQET	INSYN2A	441	Q6ZSG2
QRPKTPLTDTSVYTE	KIR3DL2	416	P43630
YSDIFTTTEPIKPEQ	PAX5	246	Q02548
TTTEPIKPEQTTEYS	PAX5	251	Q02548
ETTNIKREPTYFLTP	MUC16	5176	Q8WXI7
SSYIFVQESPTPQIK	NOL9	241	Q5SY16
VTVQTIPQATAAKYP	POC5	526	Q8NA72
SQSEYTVFVKENNPP	PCDHA3	456	Q9Y5H8
TATVYPEPQNKEAFV	ME1	526	P48163
PEQISYPVRVTDKTS	JHY	286	Q6NUN7
QYERTEPSPNTAVVQ	MBOAT2	221	Q6ZWT7
DNSKITYETQISPRP	IKBKB	391	O14920
IRIDYPPSSVVQATK	ITIH5	486	Q86UX2
PQDQLPVVTSKVYNA	SMPDL3A	156	Q92484
VYQEPNVTRLTPDST	MFI	296	Q8NCR3
EPTVFIPQSKYSVEE	FREM2	1881	Q5SZK8
KYNPNPDQSVSVTVT	EPHA4	421	P54764
HQIRKSEYTQPTPIQ	DDX42	266	Q86XP3
NPPQFKASEYTVSIQ	FAT2	2581	Q9NYQ8
PYSPQTQETDSAVQK	DIP2B	51	Q9P265
QENKGTYIPVPIVSE	F13A1	111	P00488
IASPKATYVQDSPTE	GABRA3	431	P34903
PSNSSYVETPRNKEV	TUBGCP5	121	Q96RT8
DIIYVQTDATNPSVP	INSR	611	P06213
QPKAYNPETLTTIQT	NFAT5	666	O94916
EVTQPPSYEDAVKQQ	MYOCD	716	Q8IZQ8
INQETPGSEKYSPET	HEMGN	356	Q9BXL5
NEIFQYVSTTTKVPP	NLGN4Y	601	Q8NFZ3
NTVRQSSKEPYPDFV	ERVK-21	441	P62683
ATPEEYNTVVQKPRQ	ATR	21	Q13535
QSYVLEHQKTTTPDP	HYDIN	1561	Q4G0P3
PPYKQTLVITNKEET	HYDIN	4331	Q4G0P3
YREDQPNITSPKVES	BNIP5	636	P0C671
PLPDQVVIKTQTEYQ	CALY	41	Q9NYX4
NDPTVKYETQPRFIT	CHD3	716	Q12873
QSPVPDYIKSTVETV	DHX35	251	Q9H5Z1
ESKSEVQIPYPLSEN	SQLE	201	Q14534
TYRVTPDPKNSSFEV	FGL2	226	Q14314
PQVYRQLSKPVTFVD	CYP4B1	381	P13584
FPAKTITYQAVPSEV	EIF2A	421	Q9BY44
VIKDSPQTIPTYTDA	CASP14	151	P31944
VYQPQEAEPTTSKSE	DHX34	341	Q14147
NEIFQYVSTTTKVPP	NLGN4X	601	Q8N0W4
LTNPVYPSDQTTAEK	P2RX3	371	P56373
EVPSPQSKDAQYTVT	KIF13A	911	Q9H1H9
TNTYIKTPVRGEEPV	MEX3B	96	Q6ZN04
PSSQNVTEYVVRVPK	GTF2F1	6	P35269
TTQKELPQYRAPFSV	USH2A	4926	O75445
VVQVETPGTETPSYK	RAP1GAP2	386	Q684P5
PRVVVTQPNTKYTFK	TAB2	451	Q9NYJ8
ADVKQVKVTVNYPPT	LSAMP	206	Q13449
VKVTVNYPPTITESK	LSAMP	211	Q13449
PSVYVEQKTTPNETI	SAMD9	466	Q5K651
EPYAINDSKVPSQTQ	TEX48	21	A0A1B0GUV7
LRQPSKFSTPEYTVE	ARHGAP27	546	Q6ZUM4
DPKTPDVYTQVSAFV	PRSS57	241	Q6UWY2
PYPTQITQSEKQFVV	RPN1	141	P04843
PSKEEPVNTVYSEVQ	CD84	306	Q9UIB8
VQSPEKAYSSSQPVI	WRN	1131	Q14191
KPVTQRTNEDYSPEE	SCFD2	456	Q8WU76
VYEPSTQAKPVKNTF	RWDD2A	141	Q9UIY3
EEAESYEPVKIPTQS	SPAG17	2001	Q6Q759
EIYVQKVNPSRTPAV	CLTCL1	801	P53675
EEAKNPNTSIPYAIT	SLC7A14	276	Q8TBB6
KEQSVPNPEKDTEYT	STK31	976	Q9BXU1
PQAVNNYKEEPVIVT	SKA3	176	Q8IX90
ATNSSKPQPTYEELE	SNX1	121	Q13596
SDYPQQSVTEVNLPK	ZDBF2	506	Q9HCK1
IKTVTIPTQPYQDIV	WAPL	606	Q7Z5K2
EYSSQEESQRKPLPT	UNC13B	156	O14795
FYTEEKSVRQIGTQP	TECPR2	196	O15040
KEDPANTVYSTVEIP	SLAMF7	296	Q9NQ25
EDESYTPVQAARPQT	ZNF445	31	P59923
LREAESSQIQPTVYP	WDR93	81	Q6P2C0
ESKAPEYSIVIQVPS	VPS13B	2801	Q7Z7G8
SEVDSPNVLTVQKPY	ZNF217	976	O75362
RPVTVYSISLQKFQP	TRUB1	226	Q8WWH5
SPSEVVQQVAEKQYP	HIVEP2	71	P31629
ISPPNTNAKSYEEII	HIVEP2	411	P31629
DVNPSETQYISEPKL	USP48	826	Q86UV5
VSEVKPTYRNSITVP	PURA	246	Q00577
KQTTEFYEQESITPP	TRRAP	2726	Q9Y4A5
DTETEVTQYKPPLSR	XYLT2	706	Q9H1B5
TLPNITVTDYPKQIF	TRPC3	401	Q13507
TEVIPSFYLPQISKE	VPS54	101	Q9P1Q0
EPLINTYISVPKENS	TRAPPC5	121	Q8IUR0
TSKPEPSTREQFLQY	TRIM16L	141	Q309B1
PYTQKQVTPLAVREQ	MYO7B	1381	Q6PIF6
QRSDQKVIYISDPPT	NECTIN3	346	Q9NQS3