Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	olfactory receptor activity	OR4K2 OR5V1 OR13C5 OR13C8 OR2V1 OR14I1 OR2L13 OR13J1 OR51E1 OR2T6 OR13C9 OR13C2 OR2D2 OR51V1 OR4K3 OR51B4 OR7A2P	2.15e-10	431	110	17	GO:0004984
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR4K2 OR5V1 OR13C5 OR13C8 OR2V1 OR14I1 OR2L13 OR13J1 OR51E1 OR2T6 OR13C9 OR13C2 OR2D2 OR51V1 OR4K3 OR51B4 OR7A2P	6.64e-06	884	110	17	GO:0004930
GeneOntologyMolecularFunction	testosterone 6-beta-hydroxylase activity	CYP3A7 CYP3A5	2.97e-04	5	110	2	GO:0050649
GeneOntologyMolecularFunction	pyruvate dehydrogenase (acetyl-transferring) kinase activity	PDK2 PDK3	2.97e-04	5	110	2	GO:0004740
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR4K2 OR5V1 OR13C5 OR13C8 L1CAM OR2V1 OR14I1 OR2L13 OR13J1 OR51E1 OR2T6 OR13C9 OR13C2 OR2D2 OR51V1 OR4K3 OR51B4 OR7A2P	4.14e-04	1353	110	18	GO:0004888
GeneOntologyMolecularFunction	3'-5' RNA helicase activity	SUPV3L1 AQR	4.45e-04	6	110	2	GO:0034458
GeneOntologyMolecularFunction	estrogen 2-hydroxylase activity	CYP3A7 CYP3A5	8.24e-04	8	110	2	GO:0101021
GeneOntologyBiologicalProcess	sensory perception of smell	DMXL2 OR4K2 OR5V1 OR13C5 OR13C8 OR2V1 OR14I1 OR2L13 OR13J1 TTC8 OR51E1 OR2T6 OR13C9 OR13C2 OR2D2 OR51V1 OR4K3 OR51B4 OR7A2P	3.68e-12	465	108	19	GO:0007608
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	DMXL2 OR4K2 OR5V1 OR13C5 OR13C8 OR2V1 OR14I1 OR2L13 OR13J1 TTC8 OR51E1 OR2T6 OR13C9 OR13C2 OR2D2 OR51V1 OR4K3 OR51B4 OR7A2P	6.05e-11	547	108	19	GO:0007606
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR4K2 OR5V1 OR13C5 OR13C8 OR2V1 OR14I1 OR2L13 OR13J1 OR51E1 OR2T6 OR13C9 OR13C2 OR2D2 OR51V1 OR4K3 OR51B4 OR7A2P	1.01e-10	432	108	17	GO:0050911
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR4K2 OR5V1 OR13C5 OR13C8 OR2V1 OR14I1 OR2L13 OR13J1 OR51E1 OR2T6 OR13C9 OR13C2 OR2D2 OR51V1 OR4K3 OR51B4 OR7A2P	5.98e-10	485	108	17	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR4K2 OR5V1 OR13C5 OR13C8 OR2V1 OR14I1 OR2L13 OR13J1 OR51E1 OR2T6 OR13C9 OR13C2 OR2D2 OR51V1 OR4K3 OR51B4 OR7A2P	1.93e-09	524	108	17	GO:0009593
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR4K2 OR5V1 OR13C5 OR13C8 OR2V1 OR14I1 OR2L13 OR13J1 OR51E1 OR2T6 OR13C9 OR13C2 OR2D2 OR51V1 OR4K3 OR51B4 OR7A2P	9.21e-09	582	108	17	GO:0050906
GeneOntologyBiologicalProcess	detection of stimulus	ABCA4 OR4K2 OR5V1 OR13C5 OR13C8 OR2V1 OR14I1 OR2L13 OR13J1 OR51E1 OR2T6 OR13C9 OR13C2 OR2D2 OR51V1 OR4K3 OR51B4 OR7A2P	3.68e-08	722	108	18	GO:0051606
GeneOntologyBiologicalProcess	sensory perception	DMXL2 ABCA4 OR4K2 OR5V1 OR13C5 OR13C8 OR2V1 OR14I1 OR2L13 OR13J1 TTC8 OR51E1 OR2T6 OR13C9 OR13C2 OR2D2 OR51V1 OR4K3 OR51B4 OR7A2P	6.49e-07	1072	108	20	GO:0007600
GeneOntologyBiologicalProcess	positive regulation of motile cilium assembly	ZMYND10 HTT	2.72e-05	2	108	2	GO:1905505
GeneOntologyBiologicalProcess	regulation of motile cilium assembly	ZMYND10 HTT	2.72e-05	2	108	2	GO:1905503
GeneOntologyBiologicalProcess	monocarboxylic acid metabolic process	CYP3A7 ACADS CYP3A5 PDK2 PDK3 NR1H3 HACD2 FADS2B CPT1C AGXT PLA2G4A DAGLA HTT SLC27A3	2.80e-05	731	108	14	GO:0032787
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR4K2 OR5V1 OR13C5 OR13C8 OR2V1 OR14I1 OR2L13 OR13J1 OR51E1 OR2T6 OR13C9 OR13C2 OR2D2 OR51V1 OR4K3 OR51B4 OR7A2P DAGLA HTT	1.07e-04	1395	108	19	GO:0007186
GeneOntologyBiologicalProcess	fatty acid metabolic process	ACADS PDK2 PDK3 NR1H3 HACD2 FADS2B CPT1C PLA2G4A DAGLA SLC27A3	1.55e-04	461	108	10	GO:0006631
GeneOntologyBiologicalProcess	regulation of acetyl-CoA biosynthetic process from pyruvate	PDK2 PDK3	1.62e-04	4	108	2	GO:0010510
GeneOntologyBiologicalProcess	regulation of acyl-CoA biosynthetic process	PDK2 PDK3	2.69e-04	5	108	2	GO:0050812
Domain	Olfact_rcpt	OR4K2 OR5V1 OR13C5 OR13C8 OR2V1 OR14I1 OR2L13 OR13J1 OR51E1 OR2T6 OR13C9 OR13C2 OR2D2 OR51V1 OR51B4	6.98e-09	393	107	15	IPR000725
Domain	GPCR_Rhodpsn_7TM	OR4K2 OR5V1 OR13C5 OR13C8 OR2V1 OR14I1 OR2L13 OR13J1 OR51E1 OR2T6 OR13C9 OR13C2 OR2D2 OR51V1 OR51B4	6.34e-06	670	107	15	IPR017452
Domain	G_PROTEIN_RECEP_F1_1	OR4K2 OR5V1 OR13C5 OR13C8 OR2V1 OR14I1 OR2L13 OR13J1 OR51E1 OR2T6 OR13C9 OR13C2 OR2D2 OR51V1 OR51B4	8.26e-06	685	107	15	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR4K2 OR5V1 OR13C5 OR13C8 OR2V1 OR14I1 OR2L13 OR13J1 OR51E1 OR2T6 OR13C9 OR13C2 OR2D2 OR51V1 OR51B4	9.17e-06	691	107	15	PS50262
Domain	GPCR_Rhodpsn	OR4K2 OR5V1 OR13C5 OR13C8 OR2V1 OR14I1 OR2L13 OR13J1 OR51E1 OR2T6 OR13C9 OR13C2 OR2D2 OR51V1 OR51B4	9.33e-06	692	107	15	IPR000276
Domain	7tm_1	OR4K2 OR5V1 OR13C5 OR13C8 OR14I1 OR2L13 OR13J1 OR51E1 OR2T6 OR13C9 OR13C2 OR2D2 OR51V1 OR51B4	3.19e-05	677	107	14	PF00001
Domain	Arp1	ACTR1B ACTR1A	3.25e-05	2	107	2	IPR029909
Domain	Reeler_dom	RELN FRRS1	9.72e-05	3	107	2	IPR002861
Domain	REELIN	RELN FRRS1	9.72e-05	3	107	2	PS51019
Domain	Reeler	RELN FRRS1	9.72e-05	3	107	2	PF02014
Domain	ARM-type_fold	RNPEPL1 DOCK9 PIK3C2G NBEAL2 PDS5A TAF2 CTNND1 STAG2 HTT	1.45e-04	339	107	9	IPR016024
Domain	BCDHK_Adom3	PDK2 PDK3	3.22e-04	5	107	2	PF10436
Domain	Cyt_P450_E_grp-II	CYP3A7 CYP3A5	3.22e-04	5	107	2	IPR002402
Domain	His_kinase_dom	PDK2 PDK3	3.22e-04	5	107	2	IPR005467
Domain	HIS_KIN	PDK2 PDK3	3.22e-04	5	107	2	PS50109
Domain	-	PDK2 PDK3	3.22e-04	5	107	2	1.20.140.20
Domain	BCDHK/PDK_N	PDK2 PDK3	3.22e-04	5	107	2	IPR018955
Domain	Cyt_P450_E_CYP3A	CYP3A7 CYP3A5	4.80e-04	6	107	2	IPR008072
Domain	ABC_A	ABCA4 ABCA12	2.07e-03	12	107	2	IPR026082
Domain	Cyt_P450_E_grp-I	CYP3A7 CYP3A5 CYP20A1	2.18e-03	45	107	3	IPR002401
Domain	Peptidase_M1	RNPEPL1 TAF2	2.43e-03	13	107	2	PF01433
Domain	Peptidase_M1_N	RNPEPL1 TAF2	2.43e-03	13	107	2	IPR014782
Domain	Actin_CS	ACTR1B ACTR1A	3.70e-03	16	107	2	IPR004001
Domain	ACTINS_2	ACTR1B ACTR1A	4.18e-03	17	107	2	PS00432
Domain	p450	CYP3A7 CYP3A5 CYP20A1	4.49e-03	58	107	3	PF00067
Domain	ARM-like	NBEAL2 AP5Z1 PDS5A CTNND1 STAG2 HTT	4.62e-03	270	107	6	IPR011989
Domain	Actin/actin-like_CS	ACTR1B ACTR1A	4.69e-03	18	107	2	IPR020902
Domain	HATPase_c	PDK2 PDK3	4.69e-03	18	107	2	SM00387
Domain	Cyt_P450	CYP3A7 CYP3A5 CYP20A1	4.94e-03	60	107	3	IPR001128
Domain	HATPase_c	PDK2 PDK3	5.22e-03	19	107	2	PF02518
Domain	ACTINS_ACT_LIKE	ACTR1B ACTR1A	5.22e-03	19	107	2	PS01132
Domain	-	PDK2 PDK3	5.78e-03	20	107	2	3.30.565.10
Domain	HATPase_C	PDK2 PDK3	6.36e-03	21	107	2	IPR003594
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR4K2 OR5V1 OR13C5 OR13C8 OR2V1 OR14I1 OR2L13 OR13J1 OR51E1 OR2T6 OR13C9 OR13C2 OR2D2 OR51V1 OR4K3 OR51B4	3.13e-09	417	85	16	M4072
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR4K2 OR5V1 OR13C5 OR13C8 OR14I1 OR2L13 OR13J1 OR51E1 OR2T6 OR13C9 CLCA2 OR13C2 OR2D2 OR51V1 OR51B4	9.69e-09	389	85	15	M14091
Pathway	REACTOME_SENSORY_PERCEPTION	ABCA4 OR4K2 OR5V1 OR13C5 OR13C8 OR2V1 OR14I1 OR2L13 OR13J1 OR51E1 OR2T6 OR13C9 OR13C2 OR2D2 OR51V1 OR4K3 OR51B4	1.95e-07	636	85	17	M41834
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR4K2 OR5V1 OR13C8 OR2V1 OR2L13 OR13J1 OR51E1 OR2T6 OR2D2 OR51V1 OR51B4 OR7A2P	9.37e-10	340	110	12	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR4K2 OR5V1 OR13C8 OR2V1 OR2L13 OR13J1 OR51E1 OR2T6 OR2D2 OR51V1 OR51B4 OR7A2P	9.37e-10	340	110	12	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR4K2 OR5V1 OR13C8 OR2V1 OR2L13 OR13J1 OR51E1 OR2T6 OR2D2 OR51V1 OR51B4 OR7A2P	1.04e-09	343	110	12	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR4K2 OR5V1 OR13C8 OR2V1 OR2L13 OR13J1 OR51E1 OR2T6 OR2D2 OR51V1 OR51B4 OR7A2P	1.14e-09	346	110	12	14611657
Pubmed	Organization and evolutionary relatedness of OR37 olfactory receptor genes in mouse and human.	OR13C5 OR13C8 OR13C9 OR13C2	4.60e-08	12	110	4	12906860
Pubmed	The human olfactory receptor gene family.	OR4K2 OR5V1 OR13C5 OR13C8 OR13J1 OR51E1 OR13C9 OR13C2 OR2D2 OR51V1 OR4K3 OR7A2P	1.57e-07	541	110	12	14983052
Pubmed	The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin.	UBE2W HTT	9.91e-06	2	110	2	28986324
Pubmed	Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins.	ACTR1B ACTR1A	9.91e-06	2	110	2	7696711
Pubmed	CYP3A gene expression in human gut epithelium.	CYP3A7 CYP3A5	9.91e-06	2	110	2	7894497
Pubmed	CYP3A genes and the association between prenatal methylmercury exposure and neurodevelopment.	CYP3A7 CYP3A5	9.91e-06	2	110	2	28500872
Pubmed	Marked differences between two isoforms of human pyruvate dehydrogenase kinase.	PDK2 PDK3	9.91e-06	2	110	2	10748134
Pubmed	Overexpression of PDK2 and PDK3 reflects poor prognosis in acute myeloid leukemia.	PDK2 PDK3	9.91e-06	2	110	2	30578412
Pubmed	A PIAS1 Protective Variant S510G Delays polyQ Disease Onset by Modifying Protein Homeostasis.	PIAS1 HTT	9.91e-06	2	110	2	34951052
Pubmed	Expression of CYP3A4, CYP3A5 and CYP3A7 in human duodenal tissue.	CYP3A7 CYP3A5	9.91e-06	2	110	2	8877031
Pubmed	The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test.	CYP3A7 CYP3A5	2.97e-05	3	110	2	19801957
Pubmed	Cytochrome P450 3A gene variation, steroid hormone serum levels and prostate cancer--The Rotterdam Study.	CYP3A7 CYP3A5	2.97e-05	3	110	2	20621111
Pubmed	CYP1A1, CYP3A5 and CYP3A7 polymorphisms and testicular cancer susceptibility.	CYP3A7 CYP3A5	2.97e-05	3	110	2	20345875
Pubmed	Fever Is Mediated by Conversion of Endocannabinoid 2-Arachidonoylglycerol to Prostaglandin E2.	PLA2G4A DAGLA	2.97e-05	3	110	2	26196692
Pubmed	Sequence of the 5'-flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7.	CYP3A7 CYP3A5	2.97e-05	3	110	2	7811260
Pubmed	Cytochrome P450 3As gene expression and testosterone 6 beta-hydroxylase activity in human fetal membranes and placenta at full term.	CYP3A7 CYP3A5	2.97e-05	3	110	2	20118548
Pubmed	PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington's disease.	PIAS1 HTT	2.97e-05	3	110	2	33468657
Pubmed	Ontogeny of the cell adhesion molecule L1 in the cerebellum of weaver and reeler mutant mice.	RELN L1CAM	2.97e-05	3	110	2	7969746
Pubmed	Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes.	CYP3A7 CYP3A5	2.97e-05	3	110	2	23143891
Pubmed	Development of template systems for ligand interactions of CYP3A5 and CYP3A7 and their distinctions from CYP3A4 template.	CYP3A7 CYP3A5	2.97e-05	3	110	2	33866277
Pubmed	Contribution of three CYP3A isoforms to metabolism of R- and S-warfarin.	CYP3A7 CYP3A5	2.97e-05	3	110	2	20615193
Pubmed	Comparison of steroid hormone hydroxylation mediated by cytochrome P450 3A subfamilies.	CYP3A7 CYP3A5	2.97e-05	3	110	2	32001245
Pubmed	CYP3A Polymorphism and Chronic Mercury Intoxication.	CYP3A7 CYP3A5	2.97e-05	3	110	2	32146629
Pubmed	Differences in CYP3A41G genotype distribution and haplotypes of CYP3A4, CYP3A5 and CYP3A7 in 3 Chinese populations.	CYP3A7 CYP3A5	2.97e-05	3	110	2	17582393
Pubmed	CYP3A7, CYP3A4, and CYP3A5 genetic polymorphisms in recipients rather than donors influence tacrolimus concentrations in the early stages after liver transplantation.	CYP3A7 CYP3A5	2.97e-05	3	110	2	34688813
Pubmed	DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses.	PLA2G4A DAGLA	2.97e-05	3	110	2	23103940
Pubmed	Molecular genetics of the human cytochrome P450 monooxygenase superfamily.	CYP3A7 CYP3A5 CYP20A1	3.37e-05	20	110	3	9890157
Pubmed	Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy.	CYP3A7 CYP3A5	5.92e-05	4	110	2	8694864
Pubmed	Tissue-specific kinase expression and activity regulate flux through the pyruvate dehydrogenase complex.	PDK2 PDK3	5.92e-05	4	110	2	30482839
Pubmed	Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta.	PDK2 PDK3	5.92e-05	4	110	2	17669420
Pubmed	Differing roles of pyruvate dehydrogenase kinases during mouse oocyte maturation.	PDK2 PDK3	5.92e-05	4	110	2	25991547
Pubmed	Allele and genotype frequencies of CYP3A4, CYP3A5, CYP3A7, and GSTP1 gene polymorphisms among mainland Tibetan, Mongolian, Uyghur, and Han Chinese populations.	CYP3A7 CYP3A5	5.92e-05	4	110	2	34689350
Pubmed	Diversity of the pyruvate dehydrogenase kinase gene family in humans.	PDK2 PDK3	5.92e-05	4	110	2	7499431
Pubmed	1199G>A and 2677G>T/A polymorphisms of ABCB1 independently affect tacrolimus concentration in hepatic tissue after liver transplantation.	CYP3A7 CYP3A5	5.92e-05	4	110	2	17885626
Pubmed	Cyclin-dependent kinase 5-deficient mice demonstrate novel developmental arrest in cerebral cortex.	RELN L1CAM	5.92e-05	4	110	2	9698328
Pubmed	CYP3A7, CYP3A5, CYP3A4, and ABCB1 genetic polymorphisms, cyclosporine concentration, and dose requirement in transplant recipients.	CYP3A7 CYP3A5	5.92e-05	4	110	2	18978522
Pubmed	Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP.	AMFR HTT	5.92e-05	4	110	2	20126661
Pubmed	Aberrant trajectory of thalamocortical axons associated with abnormal localization of neurocan immunoreactivity in the cerebral neocortex of reeler mutant mice.	RELN L1CAM	5.92e-05	4	110	2	16324103
Pubmed	Lack of Reelin causes malpositioning of nigral dopaminergic neurons: evidence from comparison of normal and Reln(rl) mutant mice.	RELN L1CAM	5.92e-05	4	110	2	12724835
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR13C8 OR13J1 OR2T6 OR2D2 OR4K3 OR7A2P	7.23e-05	219	110	6	12213199
Pubmed	Cytochrome P450 isoforms are differently up-regulated in aflatoxin B₁-exposed human lymphocytes and monocytes.	CYP3A7 CYP3A5	9.85e-05	5	110	2	24168324
Pubmed	Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites.	PDK2 PDK3	9.85e-05	5	110	2	11485553
Pubmed	Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene.	CYP3A7 CYP3A5	9.85e-05	5	110	2	11266076
Pubmed	Interaction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complex.	PDK2 PDK3	9.85e-05	5	110	2	11978179
Pubmed	Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase.	PDK2 PDK3	9.85e-05	5	110	2	11486000
Pubmed	Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.	CYP3A7 CYP3A5	9.85e-05	5	110	2	11093772
Pubmed	Normal development of embryonic thalamocortical connectivity in the absence of evoked synaptic activity.	RELN L1CAM	9.85e-05	5	110	2	12451131
Pubmed	Choreography of early thalamocortical development.	RELN L1CAM	9.85e-05	5	110	2	12764042
Pubmed	Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol.	CYP3A7 CYP3A5	9.85e-05	5	110	2	14559847
Pubmed	BCKDK regulates the TCA cycle through PDC in the absence of PDK family during embryonic development.	PDK2 PDK3	1.47e-04	6	110	2	33773101
Pubmed	LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver.	CYP3A5 NR1H3	1.47e-04	6	110	2	15930522
Pubmed	Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo.	DMXL2 ACTR1B HTT	1.57e-04	33	110	3	26025364
Pubmed	A role for protein inhibitor of activated STAT1 (PIAS1) in lipogenic regulation through SUMOylation-independent suppression of liver X receptors.	NR1H3 PIAS1	2.06e-04	7	110	2	22969086
Pubmed	Familial STAG2 germline mutation defines a new human cohesinopathy.	PDS5A STAG2	2.06e-04	7	110	2	29263825
Pubmed	A forward genetic screen with a thalamocortical axon reporter mouse yields novel neurodevelopment mutants and a distinct emx2 mutant phenotype.	RELN L1CAM	2.06e-04	7	110	2	21214893
Pubmed	Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.	PARN TENT2	2.06e-04	7	110	2	22727665
Pubmed	Lung dendritic-cell metabolism underlies susceptibility to viral infection in diabetes.	PDK2 PDK3	2.06e-04	7	110	2	38093014
Pubmed	The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons.	CYP3A7 CYP3A5	2.06e-04	7	110	2	11137287
Pubmed	Association between ABCC2 polymorphism and lopinavir accumulation in peripheral blood mononuclear cells of HIV-infected patients.	CYP3A7 CYP3A5	2.06e-04	7	110	2	19842932
Pubmed	Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts.	PDS5A STAG2	2.06e-04	7	110	2	15855230
Pubmed	Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1.	ACTR1B ACTR1A	2.06e-04	7	110	2	12857853
Pubmed	Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization.	PDS5A STAG2	2.74e-04	8	110	2	29867216
Pubmed	A phenotype-genotype approach to predicting CYP450 and P-glycoprotein drug interactions with the mixed inhibitor/inducer tipranavir/ritonavir.	CYP3A7 CYP3A5	2.74e-04	8	110	2	20147896
Pubmed	Quantitative analysis of cohesin complex stoichiometry and SMC3 modification-dependent protein interactions.	PDS5A STAG2	2.74e-04	8	110	2	21699228
Pubmed	ABCB1 and cytochrome P450 polymorphisms: clinical pharmacogenetics of clozapine.	CYP3A7 CYP3A5	2.74e-04	8	110	2	19593168
Pubmed	A potential role for human cohesin in mitotic spindle aster assembly.	PDS5A STAG2	2.74e-04	8	110	2	11590136
Pubmed	Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.	UBR1 RIPK1 AP5Z1 PDS5A CTNND1 TRMT61B	2.91e-04	283	110	6	21903422
Pubmed	Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	PDS5A DEPDC5 DAGLA CLUH	3.17e-04	102	110	4	9734811
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	DMXL2 PLD3 RTL4 ACTR1B ACTR1A TAF2 SSH2 CHPF CLUH	3.50e-04	689	110	9	36543142
Pubmed	Redox DAPK1 destabilizes Pellino1 to govern inflammation-coupling tubular damage during septic AKI.	RIPK1 DAPK1	3.52e-04	9	110	2	33052227
Pubmed	Dorsal-to-Ventral Cortical Expansion Is Physically Primed by Ventral Streaming of Early Embryonic Preplate Neurons.	RELN L1CAM	3.52e-04	9	110	2	31693895
Pubmed	Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression.	PDS5A STAG2	3.52e-04	9	110	2	16682347
Pubmed	Molecular characterization of ENU mouse mutagenesis and archives.	BRCA2 HTT	3.52e-04	9	110	2	16139793
Pubmed	Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase.	PDS5A STAG2	3.52e-04	9	110	2	17349791
Pubmed	Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders.	RELN L1CAM	3.52e-04	9	110	2	31691806
Pubmed	Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase.	PDS5A STAG2	3.52e-04	9	110	2	17112726
Pubmed	A crosstalk between hSiah2 and Pias E3-ligases modulates Pias-dependent activation.	ZHX2 PIAS1	3.52e-04	9	110	2	17533377
Pubmed	Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.	CHAMP1 PIAS1 PARN CTNND1	3.67e-04	106	110	4	19394292
Pubmed	Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons.	OR4K2 OR2V1 OR14I1	4.23e-04	46	110	3	32126975
Pubmed	Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl.	PDS5A STAG2	4.39e-04	10	110	2	22751501
Pubmed	Proteolytic cleavage of transmembrane cell adhesion molecule L1 by extracellular matrix molecule Reelin is important for mouse brain development.	RELN L1CAM	4.39e-04	10	110	2	29127326
Pubmed	Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development.	RELN L1CAM	4.39e-04	10	110	2	16407979
Pubmed	Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis.	PDS5A STAG2	4.39e-04	10	110	2	23242214
Pubmed	Expression of Leukaemia associated transcription factor Af9/Mllt3 in the cerebral cortex of the mouse.	RELN L1CAM	4.39e-04	10	110	2	19000783
Pubmed	Requirement of cannabinoid CB(1) receptors in cortical pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections.	L1CAM DAGLA	4.39e-04	10	110	2	21050275
Pubmed	Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.	CYP3A7 CYP3A5	4.39e-04	10	110	2	12865317
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	ELMOD2 CYP20A1 DAPK1 HACD2 POMT1 PLD3 ERI3 TTC17 CTNND1	4.76e-04	719	110	9	35337019
Pubmed	Wapl controls the dynamic association of cohesin with chromatin.	PDS5A STAG2	5.35e-04	11	110	2	17113138
Pubmed	TOPORS-mediated RAD51 SUMOylation facilitates homologous recombination repair.	PIAS1 BRCA2	5.35e-04	11	110	2	35061896
Pubmed	APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer.	BRCA2 PDS5A	5.35e-04	11	110	2	22293751
Pubmed	Small heterodimer partner SHP mediates liver X receptor (LXR)-dependent suppression of inflammatory signaling by promoting LXR SUMOylation specifically in astrocytes.	NR1H3 PIAS1	5.35e-04	11	110	2	27485016
Pubmed	Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1.	DAPK1 BRCA2	5.35e-04	11	110	2	15001356
Pubmed	USP13 interacts with cohesin and regulates its ubiquitination in human cells.	PDS5A STAG2	6.41e-04	12	110	2	33334891
Pubmed	CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes.	CYP3A7 CYP3A5	6.41e-04	12	110	2	15319333
Pubmed	COUP-TFI is required for the formation of commissural projections in the forebrain by regulating axonal growth.	RELN L1CAM	6.41e-04	12	110	2	17021036
Pubmed	SUMOylation activates large tumour suppressor 1 to maintain the tissue homeostasis during Hippo signalling.	PIAS1 BRCA2	6.41e-04	12	110	2	34267330
Cytoband	9q31.1	OR13C5 OR13C8 OR13C9 OR13C2	2.95e-06	41	110	4	9q31.1
Cytoband	Ensembl 112 genes in cytogenetic band chr9q31	OR13C5 OR13C8 OR13C9 OR13C2	3.43e-04	137	110	4	chr9q31
GeneFamily	Olfactory receptors, family 13	OR13C5 OR13C8 OR13J1 OR13C9 OR13C2	2.97e-08	23	73	5	162
GeneFamily	Cytochrome P450 family 3	CYP3A7 CYP3A5	4.43e-04	8	73	2	1002
GeneFamily	Olfactory receptors, family 51	OR51E1 OR51V1 OR51B4	7.43e-04	44	73	3	164
GeneFamily	Olfactory receptors, family 2	OR2V1 OR2L13 OR2T6 OR2D2	1.13e-03	113	73	4	149
GeneFamily	ATP binding cassette subfamily A	ABCA4 ABCA12	1.42e-03	14	73	2	805
GeneFamily	Lipases\|Arylacetamide deacetylase family	LIPK DAGLA	3.53e-03	22	73	2	464
GeneFamily	Zinc fingers CCHC-type\|RNA binding motif containing	ZCCHC2 RTL4	4.54e-03	25	73	2	74
Coexpression	GSE26351_UNSTIM_VS_WNT_PATHWAY_STIM_HEMATOPOIETIC_PROGENITORS_UP	UBR1 ELMOD2 RNPEPL1 POMT1 CHAMP1 TTC8 CASD1 TTC17 CTNND1	1.38e-07	200	107	9	M8482
Disease	Autosomal Dominant Lateral Temporal Lobe Epilepsy	RELN DEPDC5	3.47e-05	3	101	2	C1838062
Disease	tacrolimus measurement	CYP3A7 CYP3A5	6.93e-05	4	101	2	EFO_0008458
Disease	myelodysplastic syndrome	PLA2G4A TAF2	5.13e-04	10	101	2	EFO_0000198
Disease	cognitive inhibition measurement	HIVEP2 OR13C9 OR13C2	6.79e-04	50	101	3	EFO_0007969
Disease	hippocampus volume change measurement	RELN ERI3	1.18e-03	15	101	2	EFO_0021492
Disease	phosphatidylcholine 38:6 measurement	CPO DEPDC5	1.35e-03	16	101	2	EFO_0010388
Disease	Malignant neoplasm of urinary bladder	AMFR ANKFY1 BRCA2 STAG2	1.42e-03	141	101	4	C0005684
Disease	Inborn Errors of Metabolism	MYO5B PLA2G4A	1.53e-03	17	101	2	C0025521
Disease	Huntington Disease	RELN HTT	1.53e-03	17	101	2	C0020179
Disease	MYELODYSPLASTIC SYNDROME	DAPK1 BRCA2 STAG2	1.59e-03	67	101	3	C3463824
Disease	metabolonic lactone sulfate measurement	CYP3A7 CYP3A5	1.91e-03	19	101	2	EFO_0800659
Disease	bipolar disorder (is_marker_for)	RELN L1CAM	1.91e-03	19	101	2	DOID:3312 (is_marker_for)
Disease	Down syndrome (is_marker_for)	RELN ACTR1A	2.56e-03	22	101	2	DOID:14250 (is_marker_for)
Disease	Involutional paraphrenia	RELN FREM3	3.31e-03	25	101	2	C1571983
Disease	Psychosis, Involutional	RELN FREM3	3.31e-03	25	101	2	C1571984
Disease	Involutional Depression	RELN FREM3	3.31e-03	25	101	2	C0011574

Protein segments in the cluster

Peptide	Gene	Start	Entry
ESTFHMYVQPVVHPQ	ERI3	181	O43414
YLSPQQLREHHEPVM	DAPK1	1236	P53355
FHLYNLVPGIPTMEH	ELMOD2	226	Q8IZ81
LVPGIPTMEHFHQFY	ELMOD2	231	Q8IZ81
RVDLFYLHMPDHSTP	AKR7A3	106	O95154
IVHTHVTPYQVRDPM	C2orf69	326	Q8N8R5
TIFIMHGRILHYSDP	ABCA4	716	P78363
HTIYQSVELPETHQM	ACADS	26	P16219
GSMVVIPTYALHHDP	CYP3A5	391	P20815
QHLSMLEYHVPVTAG	ABCA12	2516	Q86UK0
HAVPIYEGFAMPHSI	ACTR1B	166	P42025
HISPHQPMTSLQYLH	DOP1A	1616	Q5JWR5
SMPPLFHTHYVPDIV	TENT2	116	Q6PIY7
THHYHQTLLQLPPAM	AQR	1376	O60306
HLFTRIPVEQFHSPM	AP5Z1	391	O43299
HDILYTIVQMKTPPH	DMXL2	2231	Q8TDJ6
HLSYIPPEQHTMVSL	CBLL2	176	Q8N7E2
VTQHFLGVTYETHPM	CPO	71	Q8IVL8
AICHPLHYTVIMSPQ	OR7A2P	126	Q8NGA2
VVPYMIHLLAHDPDF	PDS5A	1001	Q29RF7
HIFIDNSTQPLHFMP	PIK3C2G	291	O75747
LDVMHTVHQFYCPLP	PARN	291	O95453
AYVSIHHPHDRLMFP	NR1H3	391	Q13133
PLHMAIAYNHPDVVS	ANKFY1	546	Q9P2R3
NILMIPHPHLHQYEV	DEPDC5	531	O75140
VMNYLPTLEFSHPHR	PLD3	326	Q8IV08
LIPSAYFPHSQTMIH	PTCD3	481	Q96EY7
YFPHSQTMIHLLQAL	PTCD3	486	Q96EY7
HVHLYSMLQAPPLTS	DYNC2I2	416	Q96EX3
LVTEPTHYFIHRIMS	FSIP2	6781	Q5CZC0
PHVVPITMSYVHFLF	OR51B4	266	Q9Y5P0
IFLINIDPHLHTPMY	OR2T6	46	Q8NHC8
AVSHPLHYPILMNQR	OR2V1	126	Q8NHB1
VRTEHSLHEPMYIFL	OR51E1	51	Q8TCB6
HVIWTEPSLHQPMFY	OR51V1	56	Q9H2C8
VITVIVDPHLHSPMY	OR4K2	46	Q8NGD2
VDPHLHSPMYFLLTN	OR4K2	51	Q8NGD2
VVTIASEPHLHSPMY	OR4K3	46	Q96R72
YEGHHVMEPPVITEQ	L1CAM	26	P32004
ILISILDPHLHTPMY	OR13C5	46	Q8NGS8
MAVSVLDIHLHTPVY	OR13J1	46	Q8NGT2
ILISILDPHLHTPMY	OR13C2	46	Q8NGS9
NSKQPIHMVYVPSHL	PDK2	231	Q15119
DFFHVLPVLPSTMSH	RELN	556	P78509
ISLVHVDSQLHTPMY	OR2D2	46	Q9H210
QIEHHLFPTMPRHNY	FADS2B	421	A8MWK0
ILTTVTDPHLHTPMY	OR5V1	46	Q9UGF6
VPMAYQIVLELHFSH	POMT1	116	Q9Y6A1
IPVQQMHLFDVHNYP	CPT1C	686	Q8TCG5
YLKLLMHETQPPSHF	HTT	961	P42858
HISGASTFLPVYMHI	CASD1	446	Q96PB1
PVMYQHHTDLNPIEV	DOCK9	1936	Q9BZ29
FMHHVSLEPITCVPF	BRCA2	2321	P51587
YENVQIHMGTIHPEF	CHAMP1	26	Q96JM3
VPVHDIYVSQMTFRP	FRRS1	46	Q6ZNA5
IPIFPQLYFHMIHQR	HACD2	226	Q6Y1H2
HAVPIYEGFAMPHSI	ACTR1A	166	P61163
RSFYLEPMVTFHVHP	ASCL3	26	Q9NQ33
IISPAMLHEHLPYVV	DAGLA	641	Q9Y4D2
YPETQHVPLSQHMLG	CYP20A1	156	Q6UW02
GVVVMIPSYVLHHDP	CYP3A7	391	P24462
HILPFTMPAFHETLF	FDXACB1	381	Q9BRP7
QMNPHPVPEHLDYVI	SALL2	431	Q9Y467
HSHLLYSTIPRMQEP	CTNND1	91	O60716
HIPEQLMHIYSQPIA	FAM171B	526	Q6P995
IVLSHLDPHLHTPMY	OR2B8P	46	P59922
MSFIDPYQHIIVEHQ	PLA2G4A	1	P47712
ISVIIFDSHLHTPMY	OR13C8	46	Q8NGS7
ILISILDPHLHTPMY	OR13C9	46	Q8NGT0
VITLDQHLHTPMYFF	OR14I1	46	A6ND48
HLIHVDPRLHTPMYF	OR2L13	46	Q8N349
FYRHLGPHSPQSVMV	FREM3	656	P0C091
VMPVPYSLEHLTQFH	RTL4	51	Q6ZR62
SQHSHEVMPLLYPLF	TAF5L	86	O75529
FHFHMEHPVPAYLVA	RNPEPL1	246	Q9HAU8
QPRMYHHTIPVISLY	AGXT	256	P21549
FILHYETHPFETGMI	PWWP3B	381	Q5H9M0
YMHEVTHFCLPQLLP	TAF2	261	Q6P1X5
VMHYLIRVEPFTSLH	NBEAL2	2166	Q6ZNJ1
ISYIHLMSPFVEHIL	PIGQ	356	Q9BRB3
VAMFPPTSIYHVFHS	SLC52A2	421	Q9HAB3
IMSSLNHPHIISIYE	NUAK1	106	O60285
TKQYHEVIGHPVMPA	SI	1206	P14410
HPTAEQIEMFAYHLP	SUPV3L1	511	Q8IYB8
TSLIQDYRHPFHMTP	PIAS1	521	O75925
HMPSLHNIPVPETNY	RIPK1	496	Q13546
PIQVVYVPSHLFHML	PDK3	231	Q15120
AHQIQEMFPQVPYHL	AMFR	461	Q9UKV5
QHLTPDKIYHVTVMP	CIAO3	231	Q9H6Q4
ALTAHPVRDPVHMYQ	CHPF	321	Q8IZ52
VERDSLHFPHPVMIY	CLCA2	611	Q9UQC9
ALNLPYHMPENKTIH	CLSPN	301	Q9HAW4
TEHPNTIQEYMHLAL	CLUH	1056	O75153
HHYVNMTLPVDAVIS	UFSP2	141	Q9NUQ7
PKYQHISFMPTLHCV	ZCCHC2	711	Q9C0B9
LAPHMYEPHFNFATI	TTC8	486	Q8TAM2
MLNPHVTLPVFYPHL	TRMT61B	336	Q9BVS5
VHLLHEPPALTNEMY	TRAPPC11	756	Q7Z392
YLHPQTMVHLEGFTE	SSH2	1131	Q76I76
YMPFAPAIQTFHHLK	UBA7	896	P41226
PPHALDLMQLYTHVS	SLC27A3	596	Q5K4L6
VYPMQTEHHQTPLDY	STAG2	1141	Q8N3U4
NLLIEHPSMSVYAVH	TP53INP1	121	Q96A56
HHLAQLVPEIYFAEM	UBR1	41	Q8IWV7
ALHYAPHQMKDVPLI	TTC17	1041	Q96AE7
HVDMQHPNVILNPLY	ZHX2	96	Q9Y6X8
VMFTGENIPVHPHVY	UBE2W	71	Q96B02
FPIYMVVHHEASIIN	ZMYND10	101	O75800
NQTVTFAPFHTHYPM	TBCCD1	411	Q9NVR7
SYMTSKHLPEQPHLF	HIVEP2	1176	P31629
QPMYLTHEPLVDTHL	TBRG1	381	Q3YBR2
MHFHQLTPPLYNITK	LIPK	316	Q5VXJ0
HLLMETLNATTPHYV	MYO5B	641	Q9ULV0
HMISLPYTPQVIHCR	NEB	5066	P20929