Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	ERCC6 CHD8 CHD6 ARID1A	2.70e-05	37	94	4	GO:0140658
GeneOntologyMolecularFunction	transcription factor binding	TBX3 TCF3 BRD8 TCF12 NKX2-1 MTOR CHD6 MED1 USF1 PBX2 ARID1A IFI27	2.13e-04	753	94	12	GO:0008134
GeneOntologyBiologicalProcess	sensory organ development	ATF6 TBX3 TMC1 PDGFRA GLI2 DVL3 DIO3 ADGRV1 MED1 PBX2 ARID1A LGR5 DICER1 FOXE3	5.42e-06	730	94	14	GO:0007423
GeneOntologyBiologicalProcess	cardiac muscle cell differentiation	TBX3 PDGFRA MTOR ASB2 ARID1A DICER1 CCND2	1.66e-05	177	94	7	GO:0055007
GeneOntologyBiologicalProcess	head development	TBX3 RELN PDGFRA NKX2-1 GLI2 RAD1 DVL3 MAST1 KIF14 CHD8 MED1 PBX2 ARID1A DICER1 BAG6	1.67e-05	919	94	15	GO:0060322
GeneOntologyBiologicalProcess	thyroid hormone metabolic process	RELN DIO3 MED1 SLC16A10	1.69e-05	34	94	4	GO:0042403
GeneOntologyBiologicalProcess	embryonic morphogenesis	TBX15 TBX3 TCF3 PDGFRA MTHFD1L GLI2 DVL3 ASB2 MED1 PBX2 ARID1A ITGAV DICER1	2.06e-05	713	94	13	GO:0048598
GeneOntologyBiologicalProcess	epithelial tube morphogenesis	TBX3 PDGFRA MTHFD1L GLI2 DVL3 ASB2 MED1 ARID1A LGR5 DICER1	2.21e-05	421	94	10	GO:0060562
GeneOntologyBiologicalProcess	morphogenesis of an epithelium	TBX3 PDGFRA MTOR MTHFD1L GLI2 DVL3 ASB2 MED1 ARID1A ITGAV LGR5 DICER1	2.43e-05	619	94	12	GO:0002009
GeneOntologyBiologicalProcess	brain development	TBX3 RELN NKX2-1 GLI2 RAD1 DVL3 MAST1 KIF14 CHD8 MED1 PBX2 ARID1A DICER1 BAG6	3.34e-05	859	94	14	GO:0007420
GeneOntologyBiologicalProcess	muscle atrophy	MTOR RPS6KB1 ASB2	4.01e-05	15	94	3	GO:0014889
GeneOntologyBiologicalProcess	embryonic organ development	TBX15 TBX3 PDGFRA MTHFD1L GLI2 DVL3 ASB2 MED1 PBX2 ARID1A ITGAV	4.90e-05	561	94	11	GO:0048568
GeneOntologyBiologicalProcess	long-term memory	RELN MTOR RPS6KB1 CCND2	6.75e-05	48	94	4	GO:0007616
GeneOntologyBiologicalProcess	cardiocyte differentiation	TBX3 PDGFRA MTOR ASB2 ARID1A DICER1 CCND2	6.85e-05	221	94	7	GO:0035051
GeneOntologyBiologicalProcess	central nervous system development	TBX3 RELN NKX2-1 MTOR GLI2 RAD1 CYP26A1 DVL3 MAST1 KIF14 CHD8 MED1 PBX2 ARID1A DICER1 BAG6	9.45e-05	1197	94	16	GO:0007417
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase III	ERCC6 MTOR CHD8	9.88e-05	20	94	3	GO:0045945
GeneOntologyBiologicalProcess	cellular response to nutrient	MTOR RPS6KB1 MED1 USF1	1.15e-04	55	94	4	GO:0031670
GeneOntologyBiologicalProcess	cardiac muscle tissue development	TBX3 PDGFRA MTOR ASB2 MED1 ARID1A DICER1 CCND2	1.25e-04	327	94	8	GO:0048738
GeneOntologyBiologicalProcess	tissue morphogenesis	TBX3 PDGFRA MTOR MTHFD1L GLI2 DVL3 ASB2 MED1 ARID1A ITGAV LGR5 DICER1	1.52e-04	750	94	12	GO:0048729
GeneOntologyBiologicalProcess	inner ear development	TBX3 TMC1 GLI2 DVL3 ADGRV1 LGR5 DICER1	1.59e-04	253	94	7	GO:0048839
GeneOntologyBiologicalProcess	regulation of neuron differentiation	TCF3 RELN TCF12 MTOR GLI2 MED1 DICER1	1.67e-04	255	94	7	GO:0045664
GeneOntologyBiologicalProcess	animal organ morphogenesis	TBX15 TBX3 PDGFRA NKX2-1 MTOR MTHFD1L GLI2 DVL3 DIO3 ASB2 MED1 PBX2 ARID1A ITGAV DICER1 FOXE3	1.85e-04	1269	94	16	GO:0009887
GeneOntologyBiologicalProcess	striated muscle tissue development	TBX3 PDGFRA MTOR ASB2 MED1 ARID1A DICER1 CCND2	1.95e-04	349	94	8	GO:0014706
GeneOntologyBiologicalProcess	embryonic organ morphogenesis	TBX15 TBX3 PDGFRA MTHFD1L GLI2 DVL3 ASB2 ARID1A	2.03e-04	351	94	8	GO:0048562
GeneOntologyBiologicalProcess	chordate embryonic development	TBX15 TBX3 PDGFRA MTHFD1L GLI2 DVL3 CHD8 MED1 ARID1A ITGAV RUNDC1 DICER1 PRRC2B	2.32e-04	906	94	13	GO:0043009
GeneOntologyBiologicalProcess	cardiac muscle cell development	TBX3 PDGFRA MTOR ASB2 DICER1	2.40e-04	122	94	5	GO:0055013
GeneOntologyBiologicalProcess	embryo development	TBX15 TBX3 TCF3 PDGFRA MTHFD1L GLI2 DVL3 CHD8 ASB2 MED1 PBX2 ARID1A ITGAV RUNDC1 DICER1 BAG6 PRRC2B	2.43e-04	1437	94	17	GO:0009790
GeneOntologyBiologicalProcess	regulation of protein stability	TBX3 TCF3 FBXO4 GAPDH MTOR DVL3 ADGRV1 BAG6	2.79e-04	368	94	8	GO:0031647
GeneOntologyBiologicalProcess	embryo development ending in birth or egg hatching	TBX15 TBX3 PDGFRA MTHFD1L GLI2 DVL3 CHD8 MED1 ARID1A ITGAV RUNDC1 DICER1 PRRC2B	2.96e-04	929	94	13	GO:0009792
GeneOntologyBiologicalProcess	skeletal muscle atrophy	RPS6KB1 ASB2	3.05e-04	6	94	2	GO:0014732
GeneOntologyBiologicalProcess	positive regulation of translational initiation	MTOR RPS6KB1 RPS6KB2	3.07e-04	29	94	3	GO:0045948
GeneOntologyBiologicalProcess	epithelium development	TBX3 TMC1 PDGFRA NKX2-1 MTOR MTHFD1L MCIDAS GLI2 DVL3 ASB2 MED1 ARID1A ITGAV LGR5 DICER1 PCK2 FOXE3	3.14e-04	1469	94	17	GO:0060429
GeneOntologyBiologicalProcess	ear development	TBX3 TMC1 GLI2 DVL3 ADGRV1 LGR5 DICER1	3.28e-04	285	94	7	GO:0043583
GeneOntologyBiologicalProcess	hormone metabolic process	RELN PDGFRA CYP3A43 CYP26A1 DIO3 MED1 SLC16A10	3.35e-04	286	94	7	GO:0042445
GeneOntologyBiologicalProcess	cardiac cell development	TBX3 PDGFRA MTOR ASB2 DICER1	3.46e-04	132	94	5	GO:0055006
GeneOntologyBiologicalProcess	regulation of cellular response to stress	ATF6 BRD8 ERCC6 FBXO4 MTOR HDAC10 TMBIM6 ARID1A BAG6 TMEM33	3.95e-04	598	94	10	GO:0080135
GeneOntologyBiologicalProcess	regulation of transcription by RNA polymerase III	ERCC6 MTOR CHD8	4.13e-04	32	94	3	GO:0006359
GeneOntologyBiologicalProcess	skeletal muscle adaptation	MTOR RPS6KB1 ASB2	4.13e-04	32	94	3	GO:0043501
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	ATF6 TBX3 TCF3 BRD8 ERCC6 TCF12 NKX2-1 MCIDAS GLI2 DVL3 CHD8 CHD6 MED1 USF1 PBX2 DICER1	5.12e-04	1390	94	16	GO:0045944
GeneOntologyBiologicalProcess	regulation of cell cycle	CCND3 TBX3 TCF3 BRD8 ERCC6 FBXO4 MCIDAS RAD1 RPS6KB1 KIF14 MED1 ARID1A DICER1 FOXE3 CCND2	5.34e-04	1256	94	15	GO:0051726
GeneOntologyBiologicalProcess	embryonic hindlimb morphogenesis	TBX3 MED1 DICER1	5.40e-04	35	94	3	GO:0035116
GeneOntologyBiologicalProcess	striated muscle atrophy	RPS6KB1 ASB2	5.65e-04	8	94	2	GO:0014891
GeneOntologyBiologicalProcess	embryonic limb morphogenesis	TBX3 GLI2 MED1 PBX2 DICER1	5.84e-04	148	94	5	GO:0030326
GeneOntologyBiologicalProcess	embryonic appendage morphogenesis	TBX3 GLI2 MED1 PBX2 DICER1	5.84e-04	148	94	5	GO:0035113
GeneOntologyBiologicalProcess	cellular response to thyroid hormone stimulus	BRD8 MED1	7.25e-04	9	94	2	GO:0097067
GeneOntologyCellularComponent	chromatin	TBX15 ATF6 TBX3 TCF3 BRD8 ERCC6 TCF12 NKX2-1 DVL3 CHD8 BICRAL CHD6 MED1 USF1 PBX2 ARID1A FOXE3 CCND2	9.23e-05	1480	94	18	GO:0000785
GeneOntologyCellularComponent	nuclear envelope	ATF6 NDC1 GAPDH MTOR TMX4 AGFG1 POM121L2 IFI27 TMEM33 CCND2	2.11e-04	560	94	10	GO:0005635
GeneOntologyCellularComponent	transcription regulator complex	TBX15 ATF6 TBX3 TCF3 TCF12 NKX2-1 MED1 USF1 PBX2 FOXE3	3.47e-04	596	94	10	GO:0005667
GeneOntologyCellularComponent	nuclear protein-containing complex	TBX15 ATF6 TCF3 BRD8 ERCC6 NDC1 TCF12 RAD1 AGFG1 POM121L2 CHD8 BICRAL HDAC10 MED1 MED13L ARID1A	3.99e-04	1377	94	16	GO:0140513
GeneOntologyCellularComponent	SWI/SNF superfamily-type complex	BRD8 ERCC6 BICRAL ARID1A	9.29e-04	96	94	4	GO:0070603
Domain	Ribosomal_S6_kinase	RPS6KB1 RPS6KB2	2.35e-05	2	91	2	IPR016238
Domain	Cyclin_D	CCND3 CCND2	7.02e-05	3	91	2	IPR015451
Domain	BRK	CHD8 CHD6	3.48e-04	6	91	2	SM00592
Domain	BRK_domain	CHD8 CHD6	3.48e-04	6	91	2	IPR006576
Domain	BRK	CHD8 CHD6	3.48e-04	6	91	2	PF07533
Domain	MFS_dom	SLC16A9 SLC16A4 SLC22A23 SLC29A2 SLC16A10	5.01e-04	134	91	5	IPR020846
Domain	SNF2_N	ERCC6 CHD8 CHD6	5.01e-04	32	91	3	IPR000330
Domain	SNF2_N	ERCC6 CHD8 CHD6	5.01e-04	32	91	3	PF00176
Domain	Pkinase_C	RPS6KB1 RPS6KB2 MAST1	1.12e-03	42	91	3	PF00433
Domain	Helicase_C	ERCC6 CHD8 CHD6 DICER1	1.86e-03	107	91	4	PF00271
Domain	HELICc	ERCC6 CHD8 CHD6 DICER1	1.86e-03	107	91	4	SM00490
Domain	Helicase_C	ERCC6 CHD8 CHD6 DICER1	1.92e-03	108	91	4	IPR001650
Domain	MFS	SLC16A9 SLC16A4 SLC22A23 SLC16A10	1.92e-03	108	91	4	PS50850
Domain	HELICASE_CTER	ERCC6 CHD8 CHD6 DICER1	1.99e-03	109	91	4	PS51194
Domain	HELICASE_ATP_BIND_1	ERCC6 CHD8 CHD6 DICER1	1.99e-03	109	91	4	PS51192
Domain	DEXDc	ERCC6 CHD8 CHD6 DICER1	1.99e-03	109	91	4	SM00487
Domain	Helicase_ATP-bd	ERCC6 CHD8 CHD6 DICER1	2.05e-03	110	91	4	IPR014001
Domain	AGC-kinase_C	RPS6KB1 RPS6KB2 MAST1	2.57e-03	56	91	3	IPR000961
Domain	AGC_KINASE_CTER	RPS6KB1 RPS6KB2 MAST1	2.57e-03	56	91	3	PS51285
Domain	S_TK_X	RPS6KB1 RPS6KB2 MAST1	2.57e-03	56	91	3	SM00133
Domain	TF_T-box	TBX15 TBX3	3.04e-03	17	91	2	IPR001699
Domain	TBOX	TBX15 TBX3	3.04e-03	17	91	2	SM00425
Domain	TF_T-box_CS	TBX15 TBX3	3.04e-03	17	91	2	IPR018186
Domain	-	TBX15 TBX3	3.04e-03	17	91	2	2.60.40.820
Domain	Cyclin_C	CCND3 CCND2	3.04e-03	17	91	2	PF02984
Domain	TBOX_3	TBX15 TBX3	3.04e-03	17	91	2	PS50252
Domain	Cyclin_C-dom	CCND3 CCND2	3.04e-03	17	91	2	IPR004367
Domain	T-box	TBX15 TBX3	3.04e-03	17	91	2	PF00907
Domain	TBOX_1	TBX15 TBX3	3.04e-03	17	91	2	PS01283
Domain	Cyclin_C	CCND3 CCND2	3.04e-03	17	91	2	SM01332
Domain	TBOX_2	TBX15 TBX3	3.04e-03	17	91	2	PS01264
Domain	zf-DHHC	ZDHHC5 ZDHHC8	5.56e-03	23	91	2	PF01529
Domain	Chromo_domain	CHD8 CHD6	6.04e-03	24	91	2	IPR023780
Domain	ABC_membrane	ABCC5 ABCC12	6.04e-03	24	91	2	PF00664
Domain	MFS_1	SLC16A9 SLC16A4 SLC16A10	6.31e-03	77	91	3	PF07690
Domain	MFS	SLC16A9 SLC16A4 SLC16A10	6.31e-03	77	91	3	IPR011701
Domain	DHHC	ZDHHC5 ZDHHC8	6.55e-03	25	91	2	PS50216
Domain	Znf_DHHC_palmitoyltrfase	ZDHHC5 ZDHHC8	6.55e-03	25	91	2	IPR001594
Domain	Chromo	CHD8 CHD6	7.07e-03	26	91	2	PF00385
Domain	ABC_TM1F	ABCC5 ABCC12	8.17e-03	28	91	2	PS50929
Domain	CHROMO_1	CHD8 CHD6	8.17e-03	28	91	2	PS00598
Domain	ABC1_TM_dom	ABCC5 ABCC12	8.17e-03	28	91	2	IPR011527
Domain	CHROMO_2	CHD8 CHD6	8.17e-03	28	91	2	PS50013
Domain	CYCLINS	CCND3 CCND2	8.17e-03	28	91	2	PS00292
Pathway	KEGG_MEDICUS_REFERENCE_PDGF_PDGFR_PI3K_SIGNALING_PATHWAY	PDGFRA MTOR RPS6KB1 RPS6KB2	3.43e-07	13	68	4	M47398
Pathway	KEGG_MEDICUS_REFERENCE_RELN_VLDLR_PI3K_SIGNALING_PATHWAY	RELN MTOR RPS6KB1 RPS6KB2	6.49e-07	15	68	4	M47663
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PI3K_TO_PI3K_SIGNALING_PATHWAY	MTOR RPS6KB1 RPS6KB2	3.71e-06	7	68	3	M47407
Pathway	KEGG_MEDICUS_VARIANT_EGFR_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	MTOR RPS6KB1 RPS6KB2	1.26e-05	10	68	3	M47400
Pathway	KEGG_MEDICUS_REFERENCE_KITLG_KIT_PI3K_SIGNALING_PATHWAY	MTOR RPS6KB1 RPS6KB2	1.72e-05	11	68	3	M47403
Pathway	KEGG_MEDICUS_REFERENCE_IGF2_IGF1R_PI3K_SIGNALING_PATHWAY	MTOR RPS6KB1 RPS6KB2	1.72e-05	11	68	3	M47484
Pathway	KEGG_MEDICUS_REFERENCE_EREG_EGFR_PI3K_SIGNALING_PATHWAY	MTOR RPS6KB1 RPS6KB2	1.72e-05	11	68	3	M47499
Pathway	KEGG_MEDICUS_REFERENCE_AREG_EGFR_PI3K_SIGNALING_PATHWAY	MTOR RPS6KB1 RPS6KB2	1.72e-05	11	68	3	M47501
Pathway	KEGG_MEDICUS_VARIANT_ERBB2_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	MTOR RPS6KB1 RPS6KB2	2.29e-05	12	68	3	M47393
Pathway	WP_PI3KAKT_SIGNALING	CCND3 RELN PDGFRA MTOR RPS6KB1 RPS6KB2 ITGAV PCK2 CCND2	3.42e-05	339	68	9	M39736
Pathway	WP_THYROID_HORMONES_PRODUCTION_AND_PERIPHERAL_DOWNSTREAM_SIGNALING_EFFECTS	MTOR RPS6KB1 DIO3 ITGAV SLC16A10	8.42e-05	93	68	5	M39791
Pathway	WP_LNCRNA_IN_CANONICAL_WNT_SIGNALING_AND_COLORECTAL_CANCER	CCND3 TCF3 DVL3 CHD8 CCND2	1.08e-04	98	68	5	M39731
Pathway	REACTOME_DRUG_MEDIATED_INHIBITION_OF_CDK4_CDK6_ACTIVITY	CCND3 CCND2	2.27e-04	5	68	2	M45016
Pathway	REACTOME_DRUG_MEDIATED_INHIBITION_OF_CDK4_CDK6_ACTIVITY	CCND3 CCND2	2.27e-04	5	68	2	MM15696
Pathway	WP_PLEURAL_MESOTHELIOMA	CCND3 PDGFRA MTOR RPS6KB1 RPS6KB2 DVL3 CHD8 ITGAV CCND2	2.45e-04	439	68	9	M42563
Pathway	WP_FOLLICLE_STIMULATING_HORMONE_FSH_SIGNALING	MTOR RPS6KB1 RPS6KB2	2.89e-04	27	68	3	M39609
Pathway	WP_FOCAL_ADHESION	CCND3 MYL12A RELN PDGFRA ITGAV CCND2	3.88e-04	199	68	6	M39402
Pathway	KEGG_FOCAL_ADHESION	CCND3 MYL12A RELN PDGFRA ITGAV CCND2	3.88e-04	199	68	6	M7253
Pathway	KEGG_MEDICUS_REFERENCE_FGF_FGFR_PI3K_SIGNALING_PATHWAY	MTOR RPS6KB1 RPS6KB2	4.38e-04	31	68	3	M47396
Pathway	REACTOME_REGULATION_OF_RUNX1_EXPRESSION_AND_ACTIVITY	CCND3 CCND2	4.74e-04	7	68	2	MM15524
Pathway	WP_HAIR_FOLLICLE_DEVELOPMENT_ORGANOGENESIS_STAGE_2_OF_3	PDGFRA GLI2 CCND2	4.82e-04	32	68	3	M40041
Pathway	WP_JAKSTAT_SIGNALING_IN_THE_REGULATION_OF_BETA_CELLS	CCND3 MTOR CCND2	5.77e-04	34	68	3	M48081
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_PI3K_SIGNALING_PATHWAY	PDGFRA MTOR	6.30e-04	8	68	2	M47399
Pathway	WP_INSULIN_SIGNALING_IN_ADIPOCYTES_DIABETIC_CONDITION	MTOR RPS6KB1	6.30e-04	8	68	2	M39537
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_CDK4_TO_CELL_CYCLE_G1_S	CCND3 CCND2	6.30e-04	8	68	2	M47419
Pathway	WP_INSULIN_SIGNALING_IN_ADIPOCYTES_NORMAL_CONDITION	MTOR RPS6KB1	6.30e-04	8	68	2	M39447
Pathway	WP_CANCER_PATHWAYS	CCND3 PDGFRA MTOR GLI2 RPS6KB1 RPS6KB2 DVL3 ITGAV CCND2	6.99e-04	507	68	9	M48302
Pathway	WP_EGFR_TYROSINE_KINASE_INHIBITOR_RESISTANCE	PDGFRA MTOR RPS6KB1 RPS6KB2	7.15e-04	84	68	4	M39839
Pathway	KEGG_MEDICUS_PATHOGEN_EBV_EBNA3C_TO_CELL_CYCLE_G1_S_N00483	CCND3 CCND2	8.08e-04	9	68	2	M49010
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1	CCND3 TCF3 TCF12 ARID1A CCND2	8.48e-04	153	68	5	MM15522
Pathway	WP_NCRNAS_INVOLVED_IN_WNT_SIGNALING_IN_HEPATOCELLULAR_CARCINOMA	CCND3 DVL3 CHD8 CCND2	8.88e-04	89	68	4	M39563
Pathway	KEGG_MEDICUS_REFERENCE_P16_CELL_CYCLE_G1_S	CCND3 CCND2	1.01e-03	10	68	2	M47418
Pathway	WP_IL2_SIGNALING	RPS6KB1 RPS6KB2 CCND2	1.08e-03	42	68	3	M39536
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_MYC_TO_CELL_CYCLE_G1_S	CCND3 CCND2	1.23e-03	11	68	2	M47426
Pathway	WP_TRANSLATION_INHIBITORS_IN_CHRONICALLY_ACTIVATED_PDGFRA_CELLS	MTOR RPS6KB1 RPS6KB2	1.40e-03	46	68	3	M39805
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_MDM2_TO_P21_CELL_CYCLE_G1_S	CCND3 CCND2	1.47e-03	12	68	2	M47417
Pathway	KEGG_MEDICUS_REFERENCE_MDM2_P21_CELL_CYCLE_G1_S_N00066	CCND3 CCND2	1.73e-03	13	68	2	M47416
Pathway	KEGG_MEDICUS_REFERENCE_P15_CELL_CYCLE_G1_S	CCND3 CCND2	1.73e-03	13	68	2	M49035
Pubmed	mTOR/S6 kinase pathway contributes to astrocyte survival during ischemia.	MTOR RPS6KB1 RPS6KB2	2.04e-08	3	96	3	19535330
Pubmed	Distinct Roles of mTOR Targets S6K1 and S6K2 in Breast Cancer.	MTOR RPS6KB1 RPS6KB2	2.04e-08	3	96	3	32054043
Pubmed	Differential expression of S6K2 dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis.	MTOR RPS6KB1 RPS6KB2	8.14e-08	4	96	3	21444676
Pubmed	Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infection.	MTOR RPS6KB1 RPS6KB2	2.03e-07	5	96	3	21501832
Pubmed	The mTOR pathway negatively controls ATM by up-regulating miRNAs.	MTOR RPS6KB1 RPS6KB2	2.03e-07	5	96	3	23818585
Pubmed	Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration.	MTOR RPS6KB1 RPS6KB2	2.03e-07	5	96	3	29750193
Pubmed	S6K1 Is Required for Increasing Skeletal Muscle Force during Hypertrophy.	MTOR RPS6KB1 RPS6KB2	2.03e-07	5	96	3	27705797
Pubmed	Distinct requirements for Tcf3 and Tcf12 during oligodendrocyte development in the mouse telencephalon.	TCF3 TCF12 PDGFRA NKX2-1	2.55e-07	20	96	4	37684687
Pubmed	Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin.	MTOR RPS6KB1 RPS6KB2	4.05e-07	6	96	3	22711699
Pubmed	Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alpha.	MTOR RPS6KB1 RPS6KB2	4.05e-07	6	96	3	11733037
Pubmed	Early embryonic death in mice lacking the beta-catenin-binding protein Duplin.	CCND3 CHD8 CCND2	7.08e-07	7	96	3	15367660
Pubmed	S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade.	MTOR RPS6KB1 RPS6KB2	7.08e-07	7	96	3	18474609
Pubmed	APC controls asymmetric Wnt/β-catenin signaling and cardiomyocyte proliferation gradient in the heart.	CCND3 TBX3 PDGFRA CCND2	7.78e-07	26	96	4	26493106
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	TBX3 BRD8 TCF12 SRP54 CHD8 CHD6 PBX2 ARID1A	1.21e-06	282	96	8	23667531
Pubmed	The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration.	RPS6KB1 DVL3 CHD8 ASB2 MED1 ARID1A BAG6	1.40e-06	199	96	7	36688959
Pubmed	Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins.	CCND3 FBXO4 CCND2	1.69e-06	9	96	3	24793136
Pubmed	mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation.	MTOR RPS6KB1 RPS6KB2	1.69e-06	9	96	3	28798047
Pubmed	Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer.	MTOR RPS6KB1 RPS6KB2	1.69e-06	9	96	3	21035469
Pubmed	Balanced mTORC1 activity in oligodendrocytes is required for accurate CNS myelination.	MTOR RPS6KB1 RPS6KB2	1.69e-06	9	96	3	24948799
Pubmed	Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth.	CCND3 MTOR RPS6KB1 CCND2	2.37e-06	34	96	4	23342106
Pubmed	Oscillatory flow-induced proliferation of osteoblast-like cells is mediated by alphavbeta3 and beta1 integrins through synergistic interactions of focal adhesion kinase and Shc with phosphatidylinositol 3-kinase and the Akt/mTOR/p70S6K pathway.	MTOR RPS6KB1 ITGAV	2.41e-06	10	96	3	19889638
Pubmed	A knockout mouse approach reveals that TCTP functions as an essential factor for cell proliferation and survival in a tissue- or cell type-specific manner.	CCND3 RPS6KB1 CCND2	3.31e-06	11	96	3	17475776
Pubmed	Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium.	VIL1 PDGFRA GLI2 LGR5	3.36e-06	37	96	4	23266329
Pubmed	Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex.	CCND3 TBX3 CCND2	4.40e-06	12	96	3	24876127
Pubmed	The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond.	SLC16A9 SLC16A4 SLC16A10	7.26e-06	14	96	3	12739169
Pubmed	Identification of interaction partners for the basic-helix-loop-helix protein E47.	TCF3 TCF12 USF1	7.26e-06	14	96	3	9050988
Pubmed	Downregulation of E Protein Activity Augments an ILC2 Differentiation Program in the Thymus.	TCF3 TCF12	7.54e-06	2	96	2	28258196
Pubmed	mTORC1-S6K activation by endotoxin contributes to cytokine up-regulation and early lethality in animals.	MTOR RPS6KB1	7.54e-06	2	96	2	21200439
Pubmed	Disruption of cyclin D3 blocks proliferation of normal B-1a cells, but loss of cyclin D3 is compensated by cyclin D2 in cyclin D3-deficient mice.	CCND3 CCND2	7.54e-06	2	96	2	16818732
Pubmed	The sonic hedgehog-induced type 3 deiodinase facilitates tumorigenesis of basal cell carcinoma by reducing Gli2 inactivation.	GLI2 DIO3	7.54e-06	2	96	2	24693967
Pubmed	Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of rapamycin-dependent regulation.	MTOR RPS6KB1	7.54e-06	2	96	2	15659381
Pubmed	Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors.	TCF3 TCF12	7.54e-06	2	96	2	18093538
Pubmed	Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin.	MTOR RPS6KB2	7.54e-06	2	96	2	12087098
Pubmed	Activation of Mechanistic Target of Rapamycin (mTOR) in Human Endothelial Cells Infected with Pathogenic Spotted Fever Group Rickettsiae.	RPS6KB1 RPS6KB2	7.54e-06	2	96	2	33003310
Pubmed	Activation of mTOR/S6K But Not MAPK Pathways Might Be Associated With High Ki-67, ER(+), and HER2(-) Breast Cancer.	MTOR RPS6KB1	7.54e-06	2	96	2	25600244
Pubmed	Different interactomes for p70-S6K1 and p54-S6K2 revealed by proteomic analysis.	RPS6KB1 RPS6KB2	7.54e-06	2	96	2	27493124
Pubmed	A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1.	MTOR RPS6KB1	7.54e-06	2	96	2	16407298
Pubmed	Expression of miRNAs Targeting mTOR and S6K1 Genes of mTOR Signaling Pathway Including miR-96, miR-557, and miR-3182 in Triple-Negative Breast Cancer.	MTOR RPS6KB1	7.54e-06	2	96	2	29862445
Pubmed	Functional analysis of the human cyclin D2 and cyclin D3 promoters.	CCND3 CCND2	7.54e-06	2	96	2	8621559
Pubmed	Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB.	TCF3 TCF12	7.54e-06	2	96	2	10958665
Pubmed	An essential role for the transcription factor HEB in thymocyte survival, Tcra rearrangement and the development of natural killer T cells.	TCF3 TCF12	7.54e-06	2	96	2	20154672
Pubmed	MRP5 and MRP9 play a concerted role in male reproduction and mitochondrial function.	ABCC5 ABCC12	7.54e-06	2	96	2	35121660
Pubmed	E2A promotes the survival of precursor and mature B lymphocytes.	TCF3 TCF12	7.54e-06	2	96	2	16888011
Pubmed	The mammalian target of rapamycin-p70 ribosomal S6 kinase but not phosphatidylinositol 3-kinase-Akt signaling is responsible for fibroblast growth factor-9-induced cell proliferation.	MTOR RPS6KB1	7.54e-06	2	96	2	15760907
Pubmed	Skeletal myocyte hypertrophy requires mTOR kinase activity and S6K1.	MTOR RPS6KB1	7.54e-06	2	96	2	15963500
Pubmed	Leucine does not affect mechanistic target of rapamycin complex 1 assembly but is required for maximal ribosomal protein s6 kinase 1 activity in human skeletal muscle following resistance exercise.	MTOR RPS6KB1	7.54e-06	2	96	2	26169935
Pubmed	CCND2 and CCND3 hijack immunoglobulin light-chain enhancers in cyclin D1- mantle cell lymphoma.	CCND3 CCND2	7.54e-06	2	96	2	30538135
Pubmed	Prognostic role of cyclin D2/D3 in multiple human malignant neoplasms: A systematic review and meta-analysis.	CCND3 CCND2	7.54e-06	2	96	2	30950241
Pubmed	Essential role of PDGFRalpha-p70S6K signaling in mesenchymal cells during therapeutic and tumor angiogenesis in vivo: role of PDGFRalpha during angiogenesis.	PDGFRA RPS6KB1	7.54e-06	2	96	2	15059936
Pubmed	Baf250a orchestrates an epigenetic pathway to repress the Nkx2.5-directed contractile cardiomyocyte program in the sinoatrial node.	TBX3 ARID1A	7.54e-06	2	96	2	25145359
Pubmed	Fisetin inhibits human melanoma cell growth through direct binding to p70S6K and mTOR: findings from 3-D melanoma skin equivalents and computational modeling.	MTOR RPS6KB1	7.54e-06	2	96	2	24675012
Pubmed	E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression.	TCF3 TCF12	7.54e-06	2	96	2	17442955
Pubmed	S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase.	RPS6KB1 RPS6KB2	7.54e-06	2	96	2	17550782
Pubmed	Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity.	RPS6KB1 RPS6KB2	7.54e-06	2	96	2	18174371
Pubmed	Targeting mTORC1-mediated metabolic addiction overcomes fludarabine resistance in malignant B cells.	MTOR RPS6KB1	7.54e-06	2	96	2	25061101
Pubmed	Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells.	CCND3 CCND2	7.54e-06	2	96	2	33332554
Pubmed	Hepatic conditional knockout of ATF6 exacerbates liver metabolic damage by repressing autophage through MTOR pathway.	ATF6 MTOR	7.54e-06	2	96	2	30236984
Pubmed	mTOR is the rapamycin-sensitive kinase that confers mechanically-induced phosphorylation of the hydrophobic motif site Thr(389) in p70(S6k).	MTOR RPS6KB1	7.54e-06	2	96	2	17825298
Pubmed	Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase.	MTOR RPS6KB1	7.54e-06	2	96	2	15899889
Pubmed	Cyclin D2 and cyclin D3 play opposite roles in mouse skin carcinogenesis.	CCND3 CCND2	7.54e-06	2	96	2	16983339
Pubmed	Ankyrin-G palmitoylation and βII-spectrin binding to phosphoinositide lipids drive lateral membrane assembly.	ZDHHC5 ZDHHC8	7.54e-06	2	96	2	25049274
Pubmed	Cell cycle regulatory proteins and apoptosis in B-cell chronic lymphocytic leukemia.	CCND3 CCND2	7.54e-06	2	96	2	11726322
Pubmed	The mTOR pathway is necessary for survival of mice with short telomeres.	MTOR RPS6KB1	7.54e-06	2	96	2	32127537
Pubmed	Fenofibrate inhibits mTOR-p70S6K signaling and simultaneously induces cell death in human prostate cancer cells.	MTOR RPS6KB1	7.54e-06	2	96	2	29305864
Pubmed	The FRB domain of mTOR: NMR solution structure and inhibitor design.	MTOR RPS6KB1	7.54e-06	2	96	2	16922504
Pubmed	Correlation between circulating innate lymphoid cell precursors and thymic function.	TCF3 TCF12	7.54e-06	2	96	2	35118353
Pubmed	Negative effects of the amino acids Lys, His, and Thr on S6K1 phosphorylation in mammary epithelial cells.	MTOR RPS6KB1	7.54e-06	2	96	2	18767117
Pubmed	Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase.	RPS6KB1 RPS6KB2	7.54e-06	2	96	2	9822608
Pubmed	Cyclin D- and E-dependent kinases and the p57(KIP2) inhibitor: cooperative interactions in vivo.	CCND3 CCND2	7.54e-06	2	96	2	9858559
Pubmed	Mapping putative enhancers in mouse oocytes and early embryos reveals TCF3/12 as key folliculogenesis regulators.	TCF3 TCF12	7.54e-06	2	96	2	38839978
Pubmed	Clinical potential of the mTOR targets S6K1 and S6K2 in breast cancer.	RPS6KB1 RPS6KB2	7.54e-06	2	96	2	20953835
Pubmed	mTOR/p70S6K signal transduction pathway contributes to osteosarcoma progression and patients' prognosis.	MTOR RPS6KB1	7.54e-06	2	96	2	19936974
Pubmed	Thiazolidinediones inhibit insulin-like growth factor-i-induced activation of p70S6 kinase and suppress insulin-like growth factor-I tumor-promoting activity.	MTOR RPS6KB1	7.54e-06	2	96	2	16452250
Pubmed	mTOR and P70 S6 kinase expression in primary liver neoplasms.	MTOR RPS6KB1	7.54e-06	2	96	2	15623621
Pubmed	Cyclin D2 overexpression in transgenic mice induces thymic and epidermal hyperplasia whereas cyclin D3 expression results only in epidermal hyperplasia.	CCND3 CCND2	7.54e-06	2	96	2	10980142
Pubmed	Metabolic control by S6 kinases depends on dietary lipids.	RPS6KB1 RPS6KB2	7.54e-06	2	96	2	22412899
Pubmed	Ginsenoside CK induces apoptosis and suppresses proliferation and invasion of human osteosarcoma cells through the PI3K/mTOR/p70S6K1 pathway.	MTOR RPS6KB1	7.54e-06	2	96	2	32020217
Pubmed	D-type cyclins in adult human testis and testicular cancer: relation to cell type, proliferation, differentiation, and malignancy.	CCND3 CCND2	7.54e-06	2	96	2	10398124
Pubmed	Nuclear S6K1 regulates cAMP-responsive element-dependent gene transcription through activation of mTOR signal pathway.	MTOR RPS6KB1	7.54e-06	2	96	2	35078109
Pubmed	Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway.	RPS6KB1 RPS6KB2	7.54e-06	2	96	2	18758466
Pubmed	Combining use of Phillyrin and autophagy blocker alleviates laryngeal squamous cell carcinoma via AMPK/mTOR/p70S6K signaling.	MTOR RPS6KB1	7.54e-06	2	96	2	31147451
Pubmed	mTOR regulates skeletal muscle regeneration in vivo through kinase-dependent and kinase-independent mechanisms.	MTOR RPS6KB1	7.54e-06	2	96	2	19794149
Pubmed	Hypoxia induces permeability and giant cell responses of Andes virus-infected pulmonary endothelial cells by activating the mTOR-S6K signaling pathway.	MTOR RPS6KB1	7.54e-06	2	96	2	24067973
Pubmed	Association of variants in FRAP1 and PDGFRA with corneal curvature in Asian populations from Singapore.	PDGFRA MTOR	7.54e-06	2	96	2	21665993
Pubmed	Roles of phosphatidylinositol 3'-kinase and mammalian target of rapamycin/p70 ribosomal protein S6 kinase in K-Ras-mediated transformation of intestinal epithelial cells.	MTOR RPS6KB2	7.54e-06	2	96	2	14729629
Pubmed	G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells.	MTOR RPS6KB1	7.54e-06	2	96	2	15028555
Pubmed	Functions and regulation of the 70kDa ribosomal S6 kinases.	RPS6KB1 RPS6KB2	7.54e-06	2	96	2	20932932
Pubmed	Upstream stimulating factor 1 suppresses autophagy and hepatic lipid droplet catabolism by activating mTOR.	MTOR USF1	7.54e-06	2	96	2	30054905
Pubmed	The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury.	MTOR RPS6KB1	7.54e-06	2	96	2	28626016
Pubmed	Unique and Redundant Functions of p70 Ribosomal S6 Kinase Isoforms Regulate Mesenchymal Cell Proliferation and Migration in Pulmonary Fibrosis.	RPS6KB1 RPS6KB2	7.54e-06	2	96	2	27438654
Pubmed	Resistance exercise induced mTORC1 signaling is not impaired by subsequent endurance exercise in human skeletal muscle.	MTOR RPS6KB1	7.54e-06	2	96	2	23632629
Pubmed	E proteins orchestrate dynamic transcriptional cascades implicated in the suppression of the differentiation of group 2 innate lymphoid cells.	TCF3 TCF12	7.54e-06	2	96	2	32817168
Pubmed	Gene amplification of ribosomal protein S6 kinase-1 and -2 in gastric cancer.	RPS6KB1 RPS6KB2	7.54e-06	2	96	2	23393338
Pubmed	Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production.	RPS6KB1 RPS6KB2	7.54e-06	2	96	2	20080710
Pubmed	An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymus.	TCF3 TCF12	7.54e-06	2	96	2	11937548
Pubmed	Protein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization.	RPS6KB1 RPS6KB2	7.54e-06	2	96	2	12529391
Pubmed	Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region.	RPS6KB1 RPS6KB2	7.54e-06	2	96	2	9804755
Pubmed	mTOR-S6K1 pathway mediates cytoophidium assembly.	MTOR RPS6KB1	7.54e-06	2	96	2	30857853
Pubmed	A technique to improve diagnostic information from fine-needle aspirations: immunohistochemistry on cytoscrape.	NKX2-1 MUC3A	7.54e-06	2	96	2	19365834
Pubmed	mTOR inhibition prevents rapid-onset of carcinogen-induced malignancies in a novel inducible HPV-16 E6/E7 mouse model.	MTOR LGR5	7.54e-06	2	96	2	27538837
Interaction	PAPOLB interactions	TCF3 GAPDH MTHFD1L	1.08e-05	10	92	3	int:PAPOLB
Interaction	TCF23 interactions	TCF3 TCF12 KIF14	1.97e-05	12	92	3	int:TCF23
Interaction	PML interactions	MYL12A SFXN4 TBX3 BRD8 ERCC6 TCF12 GAPDH MTOR DVL3 KIF14 SRP54 CHD8 MED1 USF1 AHNAK2	2.00e-05	933	92	15	int:PML
Interaction	MSC interactions	TCF3 TCF12 PBX2	4.03e-05	15	92	3	int:MSC
Interaction	FERD3L interactions	TCF3 TCF12 TMBIM6	4.94e-05	16	92	3	int:FERD3L
Interaction	CSF3 interactions	TBX3 PTPRG AHNAK2	4.94e-05	16	92	3	int:CSF3
Coexpression	MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN	UBL7 TBX15 ZCCHC14 TBX3 RELN BRD8 PTPRG PDGFRA RPS6KB1 TMX4 BAG6 TMEM33 SH3BP5	3.80e-08	519	93	13	M3395
Coexpression	MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN	UBL7 TBX15 ZCCHC14 TBX3 RELN BRD8 PTPRG PDGFRA RPS6KB1 TMX4 BAG6 TMEM33 SH3BP5	6.42e-08	543	93	13	MM997
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HGABA	RELN ENOX1 SLC16A9 PPFIA2 RASGEF1B MAST1 ABCC5 MED13L LGR5 RUNDC1 LYST DICER1 PRRC2B SH3BP5 AHNAK2	7.77e-06	1106	93	15	M39071
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TMC1 PPFIA2 AGFG1 ADGRV1 HDAC10 MED13L	2.95e-06	186	95	6	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	P15-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell_of_alveolus\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CCND3 TBX3 SLC16A9 SLC22A23 AGFG1 TMBIM6	3.14e-06	188	95	6	c0a03e33027f52b5c25ffbc8f822128e5160ed20
ToppCell	COVID-19-lung-KRT8+_PATS/ADI/DATPs\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MYL12A GAPDH NKX2-1 TMBIM6 IFI27 AQP4	4.48e-06	200	95	6	12c400ebf3aaba71f1208c26f6505d0a4ace05f7
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TBX3 SLC16A9 PTPRG GLI2 ASB2	1.93e-05	153	95	5	1524557514668f515ac1bbe847611f564b265b42
ToppCell	COVID-19-Heart-CM_5_(RYR2-)\|Heart / Disease (COVID-19 only), tissue and cell type	TBX15 CLCN1 SLC22A23 ASB2 SLC16A10	2.05e-05	155	95	5	d7e26696fd9c0a759524f331243db43059b33ed9
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	OR2T29 SLC16A9 GAPDH RASGEF1B TMBIM6	4.66e-05	184	95	5	2b83c7a808e97abf836f53aa3243543c8f6762fb
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4\|TCGA-Pancreas / Sample_Type by Project: Shred V9	PTPRG PDGFRA PPFIA2 MED13L ATP10D	4.66e-05	184	95	5	67164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCell	P28-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell_of_alveolus\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CCND3 TBX3 SLC22A23 AGFG1 TMBIM6	4.91e-05	186	95	5	375642f353842184792a834361284d6897c728de
ToppCell	Control-Epithelial_cells-Tuft-like\|Control / group, cell type (main and fine annotations)	GAPDH TMBIM6 IFI27 MUC3A AHNAK2	4.91e-05	186	95	5	9aaab2e81b7ed6a75ded2c3fb1170590c57b74ba
ToppCell	P15-Endothelial-unknown_endothelial_cell-endothelial_unknown_1\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CCND3 TBX3 SLC16A9 AGFG1 CCND2	5.03e-05	187	95	5	60f41b1f1b656d211b80398aa2cf0ac0cdad9372
ToppCell	P15-Endothelial-unknown_endothelial_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CCND3 TBX3 SLC16A9 AGFG1 CCND2	5.03e-05	187	95	5	d543ddc63f864b6d0982c4ff652af174af085c4a
ToppCell	facs-Lung-nan-3m-Endothelial-Capillary_Aerocyte_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBX3 SLC16A9 PTPRG SLC22A23 AGFG1	5.29e-05	189	95	5	09dd2b3d89416192e84abe302a6237b8f3fdcb6e
ToppCell	droplet-Heart-nan-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGSF10 PDGFRA TMX4 SRP54 ASB2	5.43e-05	190	95	5	96a92212ea3fb35fa3d0da495e504edc61c71c23
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TBX3 SLC16A9 PTPRG SLC22A23 AGFG1	5.56e-05	191	95	5	718330bb97fe8a1ffd0c82e9af23311a32eacfe1
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TBX3 SLC16A9 PTPRG SLC22A23 AGFG1	5.56e-05	191	95	5	454034ad940377ee079afa8ce33f8e0bdeaf44f8
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell-Papillary_Tip_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MYL12A GAPDH IFI27 AHNAK2 CCND2	5.70e-05	192	95	5	612be3f861bd2f71a31c57f48c8b10930c3471ea
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MYL12A GAPDH IFI27 AHNAK2 CCND2	5.70e-05	192	95	5	f627a3f43e2340c8ba502211940171f25c7ff436
ToppCell	Endothelial-Endothelial-B\|Endothelial / shred on cell class and cell subclass (v4)	CCND3 TBX3 SLC16A9 SLC22A23 AGFG1	5.70e-05	192	95	5	f8d7bd81e031d09a557722627c2f6180811cc6ab
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TBX3 PTPRG IFI27 F8 SH3BP5	6.14e-05	195	95	5	23ced69fd904f1d4114b1a7f99f4b5f65ea8824b
ToppCell	facs-Thymus-nan-3m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCND3 TCF3 TCF12 ABCC5 LYST	6.14e-05	195	95	5	79114b3c78cc15c413bb58f0673e7215b784a9b6
ToppCell	Posterior_cortex-Endothelial\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CCND3 TBX15 MYL12A TBX3 SLC16A9	6.14e-05	195	95	5	988e3449691cc228cb55e5e30355136c97b12262
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYL12A PTPRG IFI27 LYST SH3BP5	6.44e-05	197	95	5	8437c33e2c4a10a1b95343431e48d5e820b1f742
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TBX3 ENOX1 PPFIA2 ABCC12 LGR5	6.44e-05	197	95	5	44673c38384453207871d3fd8e8ba9093cc06bc5
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Neuronal-neuron_precursor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TBX3 TCF12 GAPDH CHD6 ADGRV1	6.60e-05	198	95	5	e442692a8a5aad5b84eabbf051d32eae01b1069a
ToppCell	3'-Child09-12-SmallIntestine-Epithelial\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VIL1 TMBIM6 IFI27 MUC3A PCK2	6.75e-05	199	95	5	043c65bdf54a1bf0e483fea9ffc042ff5b271764
ToppCell	Bronchial-NucSeq-Endothelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TBX3 RELN IFI27 F8 SH3BP5	6.75e-05	199	95	5	36a230b80096455df26c2e2c8c05fd6b231508c5
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TBX3 PTPRG IFI27 F8 SH3BP5	6.75e-05	199	95	5	5d976d57872a8a25a11fe8cd53b01aa21a1a519a
ToppCell	COVID-19-lung-KRT8+_PATS/ADI/DATPs\|lung / Disease (COVID-19 only), tissue and cell type	MYL12A GAPDH TMBIM6 IFI27 AQP4	6.92e-05	200	95	5	038831822b1b38af4eff022bc90a9ea0a3dea675
ToppCell	Control_saline-Endothelial-Endothelial-Alv_Gen_Intermediate\|Control_saline / Treatment groups by lineage, cell group, cell type	TBX3 PTPRG GAPDH IFI27 SH3BP5	6.92e-05	200	95	5	041a34080120c9f613373c20dcc366292f558040
Drug	His-Ser	MTOR RPS6KB1 RPS6KB2 AGFG1	7.97e-07	18	94	4	CID000435727
Drug	Imatinib Mesylate	CCND3 TCF3 PDGFRA MTOR RPS6KB1 SH3BP5 CCND2	1.96e-06	141	94	7	ctd:D000068877
Drug	Everolimus	CCND3 MTOR RPS6KB1 CCND2	4.45e-06	27	94	4	ctd:D000068338
Drug	LY303511	MTOR RPS6KB1 RPS6KB2	8.01e-06	10	94	3	CID000003971
Drug	AC1L9LNU	GAPDH MTOR RPS6KB1 AGFG1 IFI27	2.03e-05	80	94	5	CID000448157
Drug	everolimus	CCND3 PDGFRA MTOR RPS6KB1 RPS6KB2 CCND2	2.15e-05	136	94	6	CID006442177
Disease	colorectal cancer (is_marker_for)	TBX3 TCF3 ERCC6 ARID1A DICER1 CCND2	7.30e-06	157	87	6	DOID:9256 (is_marker_for)
Disease	middle cerebral artery infarction (implicated_via_orthology)	PDGFRA GAPDH MTOR AQP4	9.58e-06	45	87	4	DOID:3525 (implicated_via_orthology)
Disease	Pitt-Hopkins syndrome (implicated_via_orthology)	TCF3 TCF12	2.57e-05	3	87	2	DOID:0060488 (implicated_via_orthology)
Disease	Malignant Neoplasms	CCND3 MTOR ARID1A DICER1 CCND2	3.95e-05	128	87	5	C0006826
Disease	uric acid measurement	NDC1 SLC16A9 ZDHHC5 ADGRV1 ARID1A SLC29A2 PRRC2B CCND2 SLC16A10	7.96e-05	610	87	9	EFO_0004761
Disease	Burkitt Lymphoma	TCF3 PDGFRA ARID1A	1.65e-04	36	87	3	C0006413
Disease	middle cerebral artery infarction (biomarker_via_orthology)	ERCC6 MTOR AQP4 DICER1	1.69e-04	93	87	4	DOID:3525 (biomarker_via_orthology)
Disease	CHARGE syndrome (implicated_via_orthology)	CHD8 CHD6	1.79e-04	7	87	2	DOID:0050834 (implicated_via_orthology)
Disease	colon cancer (biomarker_via_orthology)	MTOR RPS6KB1 CCND2	2.10e-04	39	87	3	DOID:219 (biomarker_via_orthology)
Disease	Colorectal Carcinoma	TCF3 ERCC6 GAPDH MTHFD1L RPS6KB1 ABCC5 ARID1A LGR5 CCND2	2.28e-04	702	87	9	C0009402
Disease	Coffin-Siris syndrome (implicated_via_orthology)	BICRAL ARID1A	3.05e-04	9	87	2	DOID:1925 (implicated_via_orthology)
Disease	alcohol dependence (implicated_via_orthology)	RPS6KB1 RPS6KB2	3.05e-04	9	87	2	DOID:0050741 (implicated_via_orthology)
Disease	Macrocephaly	CHD8 CCND2	4.65e-04	11	87	2	C0221355
Disease	Metastatic melanoma	PDGFRA MTOR MAST1	5.51e-04	54	87	3	C0278883
Disease	Acute Cerebrovascular Accidents	ZCCHC14 TBX3 ITGAV	5.51e-04	54	87	3	C0751956
Disease	Cerebrovascular accident	ZCCHC14 TBX3 ITGAV	8.26e-04	62	87	3	C0038454
Disease	stomach cancer (is_marker_for)	TBX3 ARID1A DICER1 CCND2	8.40e-04	142	87	4	DOID:10534 (is_marker_for)
Disease	free androgen index	TCF12 SLC16A9 PTPRG CYP26A1 ARID1A CCND2	8.49e-04	374	87	6	EFO_0007005
Disease	Burkitt Leukemia	TCF3 ARID1A	8.80e-04	15	87	2	C4721444
Disease	African Burkitt's lymphoma	TCF3 ARID1A	8.80e-04	15	87	2	C0343640
Disease	Colonic Neoplasms	MTOR CYP26A1 LGR5 CCND2	1.08e-03	152	87	4	C0009375
Disease	Malignant tumor of colon	MTOR CYP26A1 LGR5 CCND2	1.28e-03	159	87	4	C0007102
Disease	Endometrioma	BRD8 CYP26A1 MED1 DICER1	1.34e-03	161	87	4	C0269102
Disease	Endometriosis	BRD8 CYP26A1 MED1 DICER1	1.34e-03	161	87	4	C0014175
Disease	Colorectal Neoplasms	GAPDH ABCC5 ARID1A LGR5 CCND2	1.39e-03	277	87	5	C0009404
Disease	Malignant neoplasm of esophagus	FBXO4 GAPDH CYP26A1	1.61e-03	78	87	3	C0546837
Disease	Precursor B-cell lymphoblastic leukemia	TCF3 PDGFRA	1.74e-03	21	87	2	C1292769
Disease	status epilepticus (implicated_via_orthology)	MTOR AQP4	1.74e-03	21	87	2	DOID:1824 (implicated_via_orthology)
Disease	seminoma (is_marker_for)	PDGFRA CCND2	1.91e-03	22	87	2	DOID:4440 (is_marker_for)
Disease	Autism Spectrum Disorders	RELN DIO3 CHD8	2.05e-03	85	87	3	C1510586
Disease	Carcinoma of lung	ERCC6 CCND2	2.09e-03	23	87	2	C0684249
Disease	HMG CoA reductase inhibitor use measurement	CYP26A1 ARID1A BAG6 CCND2	2.40e-03	189	87	4	EFO_0009932
Disease	Left Ventricular Hypertrophy	MTOR RPS6KB1	2.47e-03	25	87	2	C0149721

Protein segments in the cluster

Peptide	Gene	Start	Entry
PFSFVSMATGMGPSS	PTPRG	486	P23470
SMNPARSFGPAVIMG	AQP4	211	P55087
TSASLPFMPFVMGGA	CHD8	2466	Q9HCK8
AMYPPSMIATGSIGA	CCND3	196	P30281
MPGVPAFLQGMTDFL	BAG6	636	P46379
SPVSLSEFGMMFPVL	SH3BP5	351	O60239
SEFGMMFPVLGPRSE	SH3BP5	356	O60239
SVPMGSPAFLLSLFM	BRD8	846	Q9H0E9
SSPARAPMGLFQGVM	ASB2	76	Q96Q27
MAMTDPAFGSSGRPL	FBXO4	311	Q9UKT5
MSVFLGPGMPSASLL	ADGRV1	1	Q8WXG9
SAPFLAAGVSMGGML	ABHD3	211	Q8WU67
MGEPAGVAGTMESPF	ATF6	1	P18850
LMTPASSPMGPFFGL	DICER1	16	Q9UPY3
AAMTGTFPAYGMSPS	DVL3	366	Q92997
GFIYPLVGTMSTMPG	MTHFD1L	941	Q6UB35
PVFMEQFSVPITMGG	ERCC6	701	Q03468
MPGPSAVFAMKSASS	ATP10D	1376	Q9P241
APGPINFTMFLTMFG	MYL12A	76	P19105
RFPAISRFMGPASGM	NKX2-1	121	P43699
FGSSPMPGTLTALRM	RAD1	96	O60671
MRKAPGSDPFMSSGQ	ARID1A	1236	O14497
MYPPSMIATGSVGAA	CCND2	196	P30279
LGGTPYPGMMVDSTF	PDGFRA	891	P16234
GFMVAGGLMLSSFAP	SLC16A9	86	Q7RTY1
AVPMVLSAMGFTAAG	IFI27	46	P40305
TMMGFSEEPGIIPRF	KIF14	456	Q15058
DGFMLTPVTMSFPFC	OR2T2	156	Q6IF00
SFNLSGSGDMFLGMP	PBX2	346	P40425
FQPFVGSSMFAPLKM	MED13L	941	Q71F56
LTSFPDSMLGAMFSG	KCTD21	21	Q4G0X4
TSEGQGPLPFLSMFM	NCKAP5L	396	Q9HCH0
GPLPFLSMFMGAGDA	NCKAP5L	401	Q9HCH0
GSCTUPPFMARMSAF	DIO3	166	P55073
TMYVLPFSMGPVGSP	PCK2	156	Q16822
GSVDGFMLTPITMSF	OR2T5	156	Q6IEZ7
LLFAVGFIMAGTPMA	OR3A1	201	P47881
MPTFNGSVFMPSAFI	OR52A5	1	Q9H2C5
IFVSMMSATTPSGGP	MUC3A	1626	Q02505
PPTSMFASTFFMQDG	TCF12	216	Q99081
FEGLMMSPFLPATSR	PMS2P11	226	Q13670
ALMYDMLTGAPPFTG	RPS6KB1	281	P23443
FMEPQTGPMGVATAG	GLI2	1351	P10070
PFSGETVFMSMENPG	F8	691	P00451
MPQTPPFSAMFDSSG	RASGEF1B	1	Q0VAM2
NFSMPSFPGGSMFRR	MAST1	11	Q9Y2H9
SMMSPTLASGDFPFS	MCIDAS	131	D6RGH6
SGPACEMASQTFPMF	RELN	696	P78509
GSVDGFMLTPITMSF	OR2T29	156	Q8NH02
LMITQLAGFSGPAFM	ABCC5	186	O15440
MFHVSTPLPVMTGGF	HDAC10	541	Q969S8
PQGFMAPFGSLTLNM	IGSF10	306	Q6WRI0
GRPGFATMPSVTSMS	BICRAL	521	Q6AI39
MPLGPMGFLKSALSF	CYP3A43	106	Q9HB55
MFGVGGLLSPPMATT	CHD6	2531	Q8TD26
AARSMPPSFGYSMKG	ITGAV	426	P06756
PSILPTAFMGTAMIF	TMBIM6	111	P55061
GGRSLMSPGFMVISP	LYST	2061	Q99698
MSPGFMVISPSGFTA	LYST	2066	Q99698
PGTMGFPFFGETLQM	CYP26A1	46	O43174
GFDPSLNMMTGITPI	ENOX1	76	Q8TC92
TFPGGPITTLFNMSM	MED1	566	Q15648
MMPGSSETLPAGFRL	PPFIA2	1211	O75334
PFGEPSTMGYMVALI	LGR5	716	O75473
GRLSSMNPAFVMPFL	MTOR	716	P42345
GLYASSPGMSLVMAP	RUNDC1	441	Q96C34
FDTMSAPLMGVPNSG	RTL9	71	Q8NET4
LGFSTPPGRLSMMSF	SYS1	56	Q8N2H4
MSPGPFFSITMASVC	SLC29A2	121	Q14542
SQILGMIPGFGTDFM	SRP54	346	P61011
FSSMAAAGMGPLLAT	TBX3	531	O15119
FMAPTVFLSMTPLKG	SFXN4	116	Q6P4A7
GALMYDMLTGSPPFT	RPS6KB2	256	Q9UBS0
ASFVAMAGQFLMPGL	SLC22A23	321	A1A5C7
ISAPSADAPMFVMGV	GAPDH	121	P04406
ASGAAGPVPAAMSSM	TBX15	96	Q96SF7
MAGRSDMDPPAAFSG	FOXE3	1	Q13461
PMSFFDTTPTGRLMN	ABCC12	896	Q96J65
IMTGPDMSPTSGAFS	POM121L2	906	Q96KW2
MIWMGSFFAPSLPGI	TMC1	586	Q8TDI8
SMQMPKVGFAGFPSS	AHNAK2	4756	Q8IVF2
ATFGTASMSMPTGFG	AGFG1	461	P52594
ASMSMPTGFGTPAPY	AGFG1	466	P52594
IASFTFPPGMGQFMA	CLCN1	401	P35523
SPASLTMSGMAGLFS	TMX4	151	Q9H1E5
AMQMVPVPSSTFGSF	VIL1	26	P09327
SFFAGMAVLSGPPIA	SLC16A4	431	O15374
DFSMMFPLPVTNGKG	TCF3	21	P15923
SMPSSSYRDMPGGFL	UBL7	211	Q96S82
YSSFGGVSMPPMPVA	PRRC2B	1896	Q5JSZ5
MNSSPGPAIALFLMF	TRAV9-1	1	A0A075B6T8
PSAVLANGGKMPFTM	ZC3H7A	256	Q8IWR0
SAMSSMPVGPLQGGF	ZCCHC14	686	Q8WYQ9
NFSMATFMDPGIFPR	ZDHHC5	61	Q9C0B5
NFSMATFMDPGVFPR	ZDHHC8	61	Q9ULC8
RTAGAMMQFTAPIPG	TSBP1	131	Q5SRN2
FLMPATVFMLFSGQG	TMEM33	166	P57088
QATPPGTGQFFVMMS	USF1	151	P22415
GFLLGFMSIPMTVGP	SLC16A10	421	Q8TF71
PFGTPFGSSVMNRMA	NDC1	446	Q9BTX1