Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC24A5 SLC25A27 CACNG1 ABCA2 ABCA4 HCN1 PKD1L1 CLIC6 SLC35F1 CALHM3 KCNH4 SLC5A2 SLC5A5 SLC6A2 SLC9A4 SLCO1C1 ABCB9 KCND1 KCND2 KCND3 SLC22A2 SLC25A10 SLC6A20 KCNK2 SLC25A47 KCNAB3 UNC80

1.26e-07118014727GO:0022857
GeneOntologyMolecularFunctiontransporter activity

SLC24A5 SLC25A27 CACNG1 ABCA2 ABCA4 HCN1 PKD1L1 CLIC6 SLC35F1 CALHM3 KCNH4 SLC5A2 CIDEA SLC5A5 SLC6A2 SLC9A4 SLCO1C1 ABCB9 KCND1 KCND2 KCND3 SLC22A2 SLC25A10 SLC6A20 KCNK2 SLC25A47 KCNAB3 UNC80

2.08e-07128914728GO:0005215
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC24A5 CACNG1 HCN1 PKD1L1 CALHM3 KCNH4 SLC5A2 SLC5A5 SLC6A2 SLC9A4 KCND1 KCND2 KCND3 SLC6A20 KCNK2 KCNAB3

3.44e-0746514716GO:0046873
GeneOntologyMolecularFunctionA-type (transient outward) potassium channel activity

KCND1 KCND2 KCND3

1.56e-0641473GO:0005250
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC24A5 SLC25A27 CACNG1 HCN1 PKD1L1 CALHM3 KCNH4 SLC5A2 SLC5A5 SLC6A2 SLC9A4 KCND1 KCND2 KCND3 SLC6A20 KCNK2 KCNAB3 UNC80

1.95e-0666414718GO:0008324
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC24A5 SLC25A27 CACNG1 HCN1 PKD1L1 CLIC6 CALHM3 KCNH4 SLC5A2 SLC5A5 SLC6A2 SLC9A4 KCND1 KCND2 KCND3 SLC25A10 SLC6A20 KCNK2 KCNAB3

3.12e-0675814719GO:0015318
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC24A5 SLC25A27 CACNG1 HCN1 PKD1L1 CALHM3 KCNH4 SLC5A2 SLC5A5 SLC6A2 SLC9A4 KCND1 KCND2 KCND3 SLC6A20 KCNK2 KCNAB3

3.83e-0662714717GO:0022890
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

SLC24A5 HCN1 KCNH4 SLC9A4 KCND1 KCND2 KCND3 KCNK2 KCNAB3

4.14e-061671479GO:0015079
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC24A5 SLC25A27 CACNG1 HCN1 PKD1L1 CLIC6 CALHM3 KCNH4 SLC5A2 SLC5A5 SLC6A2 SLC9A4 KCND1 KCND2 KCND3 SLC6A20 KCNK2 KCNAB3 UNC80

5.97e-0679314719GO:0015075
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

CACNG1 HCN1 CALHM3 KCNH4 KCND1 KCND2 KCND3 KCNK2 KCNAB3

8.33e-061821479GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

CACNG1 HCN1 CALHM3 KCNH4 KCND1 KCND2 KCND3 KCNK2 KCNAB3

9.10e-061841479GO:0022832
GeneOntologyMolecularFunctionmonoatomic cation channel activity

SLC24A5 CACNG1 HCN1 PKD1L1 CALHM3 KCNH4 KCND1 KCND2 KCND3 KCNK2 KCNAB3 UNC80

9.17e-0634314712GO:0005261
GeneOntologyMolecularFunctionvoltage-gated potassium channel activity

HCN1 KCNH4 KCND1 KCND2 KCND3 KCNK2 KCNAB3

1.05e-051021477GO:0005249
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

CACNG1 HCN1 KCNH4 KCND1 KCND2 KCND3 KCNK2 KCNAB3

1.71e-051521478GO:0022843
GeneOntologyMolecularFunctionmonoatomic ion channel activity

SLC24A5 CACNG1 HCN1 PKD1L1 CLIC6 CALHM3 KCNH4 KCND1 KCND2 KCND3 KCNK2 KCNAB3 UNC80

3.60e-0545914713GO:0005216
GeneOntologyMolecularFunctionoutward rectifier potassium channel activity

KCND1 KCND2 KCND3 KCNK2

4.34e-05271474GO:0015271
GeneOntologyMolecularFunctionpotassium channel activity

HCN1 KCNH4 KCND1 KCND2 KCND3 KCNK2 KCNAB3

4.57e-051281477GO:0005267
GeneOntologyMolecularFunctionoxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

GMPR2 GMPR

5.38e-0521472GO:0046857
GeneOntologyMolecularFunctionGMP reductase activity

GMPR2 GMPR

5.38e-0521472GO:0003920
GeneOntologyMolecularFunctionendodeoxyribonuclease activity, producing 5'-phosphomonoesters

APEX1 EXO1 DNASE1L2

1.34e-04141473GO:0016888
GeneOntologyMolecularFunctionchannel activity

SLC24A5 CACNG1 HCN1 PKD1L1 CLIC6 CALHM3 KCNH4 KCND1 KCND2 KCND3 KCNK2 KCNAB3 UNC80

1.39e-0452514713GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

SLC24A5 CACNG1 HCN1 PKD1L1 CLIC6 CALHM3 KCNH4 KCND1 KCND2 KCND3 KCNK2 KCNAB3 UNC80

1.42e-0452614713GO:0022803
GeneOntologyMolecularFunctionvitamin binding

DMGDH ABCA4 ACACB TKTL1 FASN AGXT DHTKD1

1.93e-041611477GO:0019842
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC24A5 ABCA2 ABCA4 SLC5A2 SLC5A5 SLC6A2 SLC9A4 SLCO1C1 ABCB9 SLC22A2 SLC25A10 SLC6A20

2.19e-0447714712GO:0022804
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC24A5 HCN1 SLC5A2 SLC5A5 SLC6A2 SLC9A4 SLC6A20

2.78e-041711477GO:0015081
GeneOntologyMolecularFunctiongated channel activity

CACNG1 HCN1 CALHM3 KCNH4 KCND1 KCND2 KCND3 KCNK2 KCNAB3

8.41e-043341479GO:0022836
GeneOntologyMolecularFunctiontriacylglycerol lipase activity

DAGLB PNLIPRP2 PNPLA3

8.98e-04261473GO:0004806
GeneOntologyMolecularFunctionNADP binding

CRYZ NOX1 FDXR NNT

1.13e-03621474GO:0050661
GeneOntologyMolecularFunctionthiamine pyrophosphate binding

TKTL1 DHTKD1

1.46e-0381472GO:0030976
GeneOntologyMolecularFunctiondouble-stranded DNA exodeoxyribonuclease activity

APEX1 EXO1

1.46e-0381472GO:0008309
GeneOntologyMolecularFunctionoxidoreductase activity

DMGDH STEAP4 APEX1 GMPR2 DHRS1 TXNRD1 FASN CRYZ NOX1 FDXR GMPR DHTKD1 NNT KCNAB3

1.59e-0376614714GO:0016491
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC24A5 SLC5A2 SLC5A5 SLC6A2 SLC9A4 SLCO1C1 SLC25A10 SLC6A20

1.60e-032961478GO:0015291
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

SLC24A5 SLC25A27 CACNG1 HCN1 PKD1L1 STEAP4 CLIC6 CALHM3 DYSF KCNH4 SLC5A2 SLC5A5 SLC6A2 SLC9A4 KCND1 KCND2 KCND3 SLC25A10 SLC6A20 KCNK2 NNT KCNAB3

3.19e-06101714722GO:0098660
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

SLC24A5 SLC25A27 CACNG1 HCN1 PKD1L1 STEAP4 CALHM3 DYSF KCNH4 SLC5A2 SLC5A5 SLC6A2 SLC9A4 KCND1 KCND2 KCND3 SLC6A20 KCNK2 NNT KCNAB3 UNC80

3.44e-0694214721GO:0098655
GeneOntologyBiologicalProcessmonoatomic ion transport

SLC24A5 SLC25A27 CACNG1 HCN1 PKD1L1 STEAP4 CLIC6 CALHM3 DYSF KCNH4 SLC5A2 SLC5A5 SLC6A2 SLC9A4 SLCO1C1 KCND1 KCND2 KCND3 SLC22A2 SLC25A10 SLC6A20 KCNK2 NNT KCNAB3 EPB41 UNC80

4.30e-06137414726GO:0006811
GeneOntologyBiologicalProcessmonoatomic cation transport

SLC24A5 SLC25A27 CACNG1 HCN1 PKD1L1 STEAP4 CALHM3 DYSF KCNH4 SLC5A2 SLC5A5 SLC6A2 SLC9A4 KCND1 KCND2 KCND3 SLC22A2 SLC6A20 KCNK2 NNT KCNAB3 EPB41 UNC80

7.53e-06115714723GO:0006812
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

SLC24A5 SLC25A27 CACNG1 HCN1 PKD1L1 STEAP4 CALHM3 DYSF KCNH4 SLC5A2 SLC5A5 SLC6A2 SLC9A4 KCND1 KCND2 KCND3 SLC6A20 KCNK2 NNT KCNAB3

9.01e-0692214720GO:0098662
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

SLC24A5 SLC25A27 CACNG1 HCN1 PKD1L1 STEAP4 CLIC6 CALHM3 DYSF KCNH4 SLC5A2 SLC5A5 SLC6A2 SLC9A4 KCND1 KCND2 KCND3 SLC6A20 KCNK2 NNT KCNAB3 UNC80

1.37e-05111514722GO:0034220
GeneOntologyBiologicalProcessthyroid hormone generation

MED1 SLC5A5 SLCO1C1 PAX8

2.79e-05251474GO:0006590
GeneOntologyBiologicalProcesspotassium ion transmembrane transport

SLC24A5 HCN1 KCNH4 SLC9A4 KCND1 KCND2 KCND3 KCNK2 KCNAB3

4.43e-052321479GO:0071805
GeneOntologyBiologicalProcessNADP metabolic process

ACACB TXNRD1 NOX1 FDXR NNT

4.90e-05561475GO:0006739
GeneOntologyBiologicalProcessmetal ion transport

SLC24A5 CACNG1 HCN1 PKD1L1 STEAP4 CALHM3 DYSF KCNH4 SLC5A2 SLC5A5 SLC6A2 SLC9A4 KCND1 KCND2 KCND3 SLC6A20 KCNK2 KCNAB3 EPB41

9.22e-05100014719GO:0030001
GeneOntologyBiologicalProcessthyroid hormone metabolic process

MED1 SLC5A5 SLCO1C1 PAX8

9.72e-05341474GO:0042403
GeneOntologyBiologicalProcesspotassium ion transport

SLC24A5 HCN1 KCNH4 SLC9A4 KCND1 KCND2 KCND3 KCNK2 KCNAB3

1.49e-042721479GO:0006813
GeneOntologyBiologicalProcessprotein homooligomerization

ACACB HCN1 STEAP4 ALS2 CRYZ KCND1 KCND2 KCND3

2.09e-042241478GO:0051260
GeneOntologyCellularComponentvoltage-gated potassium channel complex

HCN1 KCNH4 KCND1 KCND2 KCND3 KCNK2 KCNAB3

3.81e-06911487GO:0008076
GeneOntologyCellularComponentcation channel complex

CACNG1 HCN1 PKD1L1 KCNH4 KCND1 KCND2 KCND3 KCNK2 KCNAB3 UNC80

7.00e-0623514810GO:0034703
GeneOntologyCellularComponentpotassium channel complex

HCN1 KCNH4 KCND1 KCND2 KCND3 KCNK2 KCNAB3

9.26e-061041487GO:0034705
GeneOntologyCellularComponentGMP reductase complex

GMPR2 GMPR

4.98e-0521482GO:1902560
GeneOntologyCellularComponentmonoatomic ion channel complex

CACNG1 HCN1 PKD1L1 CLIC6 KCNH4 KCND1 KCND2 KCND3 KCNK2 KCNAB3 UNC80

8.19e-0537814811GO:0034702
GeneOntologyCellularComponenttransmembrane transporter complex

CACNG1 ABCA2 HCN1 PKD1L1 CLIC6 KCNH4 KCND1 KCND2 KCND3 KCNK2 KCNAB3 UNC80

3.56e-0452314812GO:1902495
GeneOntologyCellularComponenttransporter complex

CACNG1 ABCA2 HCN1 PKD1L1 CLIC6 KCNH4 KCND1 KCND2 KCND3 KCNK2 KCNAB3 UNC80

5.57e-0455014812GO:1990351
DomainShal-type_N

KCND1 KCND2 KCND3

4.58e-0731453IPR021645
DomainK_chnl_volt-dep_Kv4_C

KCND1 KCND2 KCND3

4.58e-0731453IPR024587
DomainDUF3399

KCND1 KCND2 KCND3

4.58e-0731453PF11879
DomainK_chnl_volt-dep_Kv4

KCND1 KCND2 KCND3

4.58e-0731453IPR003975
DomainShal-type

KCND1 KCND2 KCND3

4.58e-0731453PF11601
DomainGMPR

GMPR2 GMPR

5.99e-0521452IPR005993
DomainIMPDH

GMPR2 GMPR

3.56e-0441452PF00478
DomainIMP_DH_GMPRt

GMPR2 GMPR

3.56e-0441452IPR001093
DomainIMP_DH_GMP_RED

GMPR2 GMPR

3.56e-0441452PS00487
DomainIMP_DH/GMP_Rdtase_CS

GMPR2 GMPR

3.56e-0441452IPR015875
PathwayREACTOME_POTASSIUM_CHANNELS

HCN1 KCNH4 KCND1 KCND2 KCND3 KCNK2 KCNAB3

1.34e-05981137MM14545
PathwayREACTOME_PHASE_1_INACTIVATION_OF_FAST_NA_CHANNELS

KCND1 KCND2 KCND3

1.71e-0571133M27457
PathwayREACTOME_PHASE_1_INACTIVATION_OF_FAST_NA_CHANNELS

KCND1 KCND2 KCND3

1.71e-0571133MM15199
PathwayREACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS

KCNH4 KCND1 KCND2 KCND3 KCNAB3

1.80e-05411135MM14546
PathwayREACTOME_POTASSIUM_CHANNELS

HCN1 KCNH4 KCND1 KCND2 KCND3 KCNK2 KCNAB3

1.85e-051031137M1073
PathwayREACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS

KCNH4 KCND1 KCND2 KCND3 KCNAB3

2.29e-05431135M1056
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC24A5 SLC5A2 SLC5A5 SLC6A2 SLC9A4 SLCO1C1 SLC22A2 SLC25A10 SLC6A20

1.25e-042381139MM15076
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC24A5 SLC5A2 SLC5A5 SLC6A2 SLC9A4 SLCO1C1 SLC22A2 SLC25A10 SLC6A20

1.75e-042491139M5988
PathwayREACTOME_ACTIVATION_OF_GENE_EXPRESSION_BY_SREBF_SREBP

ACACB GPAM MED1 FASN

3.46e-04421134M27172
PathwayREACTOME_NEURONAL_SYSTEM

HCN1 GRM5 KCNH4 KCND1 KCND2 KCND3 SLC22A2 KCNK2 KCNAB3 EPB41

3.57e-0433511310MM14503
PathwayREACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS

SLC6A2 SLC22A2 SLC6A20

4.43e-04191133M27362
PathwayREACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS

SLC6A2 SLC22A2 SLC6A20

4.43e-04191133MM15107
Pubmed

Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

OBSCN RNF213 GPAM ALS2 HUWE1 ARID2 PLXNA4 DHTKD1

1.29e-08101148810997877
Pubmed

Unique clustering of A-type potassium channels on different cell types of the main olfactory bulb.

KCND1 KCND2 KCND3

7.55e-083148318371079
Pubmed

Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA).

KCND1 KCND2 KCND3

7.55e-083148310729221
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

UBR4 HUWE1 NWD2 ABCB9 KCND2 ARNT2

2.04e-0687148612465718
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

CACNG1 HCN1 KCND1 KCND2 KCND3 KCNK2 KCNAB3

2.34e-06139148716985003
Pubmed

Expression of astrocyte-related receptors in cortical dysplasia with intractable epilepsy.

GRM5 KCND1 KCND2

2.61e-067148325003238
Pubmed

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.

DMGDH EPPK1 ANXA7 UBR4 OBSCN RNF213 GFPT1 VAC14 NNT

6.71e-06304148932235678
Pubmed

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

DMGDH SLC25A27 ACACB MRPS16 GPAM DHRS1 MRPL2 TXNRD1 FASN FDXR SLC25A10 AGXT SLC25A47 DHTKD1 NNT

1.05e-059261481520877624
Pubmed

TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.

UBR4 MED14 HUWE1 MED1

1.17e-0533148433567268
Pubmed

In vitro and mouse studies supporting therapeutic utility of triiodothyroacetic acid in MCT8 deficiency.

SLCO1C1 PAX8

1.80e-052148225389909
Pubmed

Mutations in the genes KCND2 and KCND3 encoding the ion channels Kv4.2 and Kv4.3, conducting the cardiac fast transient outward current (ITO,f), are not a frequent cause of long QT syndrome.

KCND2 KCND3

1.80e-052148215563876
Pubmed

S-glutathionylation of an auxiliary subunit confers redox sensitivity to Kv4 channel inactivation.

KCND1 KCND2

1.80e-052148224675763
Pubmed

Kv4.3-Encoded Fast Transient Outward Current Is Presented in Kv4.2 Knockout Mouse Cardiomyocytes.

KCND2 KCND3

1.80e-052148226196737
Pubmed

Genomic organisation and chromosomal localisation of two members of the KCND ion channel family, KCND2 and KCND3.

KCND2 KCND3

1.80e-052148210942109
Pubmed

Dendritic Kv4.2 potassium channels selectively mediate spatial pattern separation in the dentate gyrus.

KCND2 KCND3

1.80e-052148234386734
Pubmed

Isolation and characterization of the human gene encoding Ito: further diversity by alternative mRNA splicing.

KCND2 KCND3

1.80e-05214829843794
Pubmed

Reaction mechanism and specificity of human GMP reductase. Substrates, inhibitors, activators, and inactivators.

GMPR2 GMPR

1.80e-0521482218932
Pubmed

Differential expression of I(A) channel subunits Kv4.2 and Kv4.3 in mouse visual cortical neurons and synapses.

KCND2 KCND3

1.80e-052148217122053
Pubmed

Transcriptional regulation of human sodium/iodide symporter gene: a role for redox factor-1.

APEX1 SLC5A5

1.80e-052148214630715
Pubmed

NADPH-dependent GMP reductase isoenzyme of human (GMPR2). Expression, purification, and kinetic properties.

GMPR2 GMPR

1.80e-052148212009299
Pubmed

Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification.

SLC6A2 LMO1 KCND2 PLXNA4 FST

2.01e-0577148529445148
Pubmed

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.

KCNH4 KCND1 KCND2 KCND3

2.55e-0540148416382104
Pubmed

Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein.

KCND1 KCND2 KCND3

3.31e-0515148310479680
Pubmed

The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.

SLC25A27 GFPT1 SLC6A2 SLC9A4 SLCO1C1 SLC22A2 CHST2

3.66e-05212148719521566
Pubmed

Expression, regulation, and function of paired-box gene 8 in the human placenta and placental cancer cell lines.

SLC5A5 PAX8

5.38e-053148215961562
Pubmed

Overexpression of Fatty Acid Synthase Upregulates Glutamine-Fructose-6-Phosphate Transaminase 1 and O-Linked N-Acetylglucosamine Transferase to Increase O-GlcNAc Protein Glycosylation and Promote Colorectal Cancer Growth.

GFPT1 FASN

5.38e-053148238732103
Pubmed

Molecular dissection of I(A) in cortical pyramidal neurons reveals three distinct components encoded by Kv4.2, Kv4.3, and Kv1.4 alpha-subunits.

KCND2 KCND3

5.38e-053148220371829
Pubmed

Toll-like receptor 3 controls QT interval on the electrocardiogram by targeting the degradation of Kv4.2/4.3 channels in the endoplasmic reticulum.

KCND2 KCND3

5.38e-053148230758987
Pubmed

Role of heteromultimers in the generation of myocardial transient outward K+ currents.

KCND2 KCND3

5.38e-053148211909823
Pubmed

I(A) channels encoded by Kv1.4 and Kv4.2 regulate neuronal firing in the suprachiasmatic nucleus and circadian rhythms in locomotor activity.

KCND2 KCND3

5.38e-053148222815518
Pubmed

Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate.

ACACB FASN

5.38e-053148218455495
Pubmed

ChIPping away at potassium channel regulation.

KCND1 KCND2

5.38e-053148210700246
Pubmed

A-type K+ channels encoded by Kv4.2, Kv4.3 and Kv1.4 differentially regulate intrinsic excitability of cortical pyramidal neurons.

KCND2 KCND3

5.38e-053148222615428
Pubmed

Pituitary adenylate cyclase activating polypeptide reduces expression of Kv1.4 and Kv4.2 subunits underlying A-type K(+) current in adult mouse olfactory neuroepithelia.

KCND1 KCND2

5.38e-053148216426762
Pubmed

The miR-146b-3p/PAX8/NIS Regulatory Circuit Modulates the Differentiation Phenotype and Function of Thyroid Cells during Carcinogenesis.

SLC5A5 PAX8

5.38e-053148226282166
Pubmed

Gene mutational analysis in a cohort of Chinese children with unexplained epilepsy: Identification of a new KCND3 phenotype and novel genes causing Dravet syndrome.

HCN1 KCND3

5.38e-053148230776697
Pubmed

Hedgehog interacting protein activates sodium-glucose cotransporter 2 expression and promotes renal tubular epithelial cell senescence in a mouse model of type 1 diabetes.

SLC5A2 PAX8

5.38e-053148236260124
Pubmed

MED14 and MED1 differentially regulate target-specific gene activation by the glucocorticoid receptor.

MED14 MED1

5.38e-053148216239257
Pubmed

The role of CA-125, GLS and FASN in predicting cytoreduction for epithelial ovarian cancers.

MUC16 FASN

5.38e-053148232698888
Pubmed

Role of PAX-8, CD5, and CD117 in distinguishing thymic carcinoma from poorly differentiated lung carcinoma.

CD5 PAX8

5.38e-053148223958552
Pubmed

Blood-Brain Barrier: From Physiology to Disease and Back.

ABCA2 SLC5A5 SLCO1C1 SLC22A2 SLC6A20

8.94e-05105148530280653
Pubmed

UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.

UBR4 RNF213 GFPT1

9.49e-0521148337422473
Pubmed

Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model.

ABCA2 SLCO1C1 SLC22A2

9.49e-0521148323137377
Pubmed

Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway.

APEX1 TXNRD1

1.07e-04414829207062
Pubmed

Exome sequencing in seven families and gene-based association studies indicate genetic heterogeneity and suggest possible candidates for fibromuscular dysplasia.

OBSCN RNF213

1.07e-044148226147384
Pubmed

TRIM26 promotes non-small cell lung cancer survival by inducing PBX1 degradation.

UBR4 HUWE1

1.07e-044148237324936
Pubmed

Expression specificity of the mouse exonuclease 1 (mExo1) gene.

CR2 EXO1

1.07e-044148210497278
Pubmed

Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1.

KCND2 KCND3

1.07e-044148214980207
Pubmed

Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10).

KCND1 KCND2

1.07e-044148215454437
Pubmed

Parvalbumin+ Neurons and Npas1+ Neurons Are Distinct Neuron Classes in the Mouse External Globus Pallidus.

KCND2 KCND3

1.07e-044148226311767
Pubmed

Accessory Kvbeta1 subunits differentially modulate the functional expression of voltage-gated K+ channels in mouse ventricular myocytes.

KCND2 KCND3

1.07e-044148215662035
Pubmed

Minireview: thyrotropin receptor signaling in development and differentiation of the thyroid gland: insights from mouse models and human diseases.

SLC5A5 PAX8

1.07e-044148215231702
Pubmed

The selection of marginal zone B cells differs from that of B-1a cells.

CR2 CD5

1.07e-044148214662849
Pubmed

Functional interactions between the estrogen receptor and DRIP205, a subunit of the heteromeric DRIP coactivator complex.

MED14 MED1

1.07e-044148210770935
Pubmed

IA Channels Encoded by Kv1.4 and Kv4.2 Regulate Circadian Period of PER2 Expression in the Suprachiasmatic Nucleus.

KCND2 KCND3

1.07e-044148226152125
Pubmed

Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).

ACACB SLC5A2 FASN

1.10e-0422148320965718
Pubmed

SOCS2 Binds to and Regulates EphA2 through Multiple Mechanisms.

GFPT1 NWD2 SHROOM1 SLC4A1AP SLC25A10

1.11e-04110148528883622
Pubmed

ATP-citrate lyase deficiency in the mouse.

ACACB GPAM FASN

1.26e-0423148314662765
Pubmed

Defining the membrane proteome of NK cells.

ABCA2 DPY19L1 MYO9B ORC6 ANXA7 UBR4 MED14 RNF213 ERMP1 HUWE1 MED1 KSR1 FASN NNT STAG2

1.46e-0411681481519946888
Pubmed

A mitochondrial protein compendium elucidates complex I disease biology.

DMGDH SLC25A27 ACACB MRPS16 GPAM DHRS1 MRPL2 TXNRD1 FASN FDXR SLC25A10 AGXT SLC25A47 NNT

1.62e-0410471481418614015
Pubmed

Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes.

KCND2 KCND3

1.78e-045148219213956
Pubmed

Binding of liganded vitamin D receptor to the vitamin D receptor interacting protein coactivator complex induces interaction with RNA polymerase II holoenzyme.

MED14 MED1

1.78e-045148210753860
Pubmed

SGLT2 inhibition and renal urate excretion: role of luminal glucose, GLUT9, and URAT1.

SLC5A2 PAX8

1.78e-045148230427222
Pubmed

The mediator complex functions as a coactivator for GATA-1 in erythropoiesis via subunit Med1/TRAP220.

MED14 MED1

1.78e-045148217132730
Pubmed

Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program.

ACACB FASN

1.78e-045148237163372
Pubmed

Non-coding RNA Neat1 and Abhd11os expressions are dysregulated in medium spiny neurons of Huntington disease model mice.

SMIM10L2A SMIM10L2B

1.78e-045148230391555
Pubmed

Roles of thioredoxin reductase 1 and APE/Ref-1 in the control of basal p53 stability and activity.

APEX1 TXNRD1

1.78e-045148215824742
Pubmed

The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient.

KCND2 KCND3

1.78e-045148216239150
Pubmed

Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules.

PAX8 VCAN SLC6A20 CLP1

2.20e-0469148421491542
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

TPP2 EPPK1 POLR1A ANXA7 UBR4 MED14 HUWE1 GMPR2 GFPT1 FASN FDXR

2.26e-047041481129955894
Pubmed

Mediator and cohesin connect gene expression and chromatin architecture.

MED14 MED1 STAG2

2.29e-0428148320720539
Pubmed

Gene expression and characterization of clonally derived murine embryonic brown and brite adipocytes.

ACACB CIDEA FASN

2.54e-0429148338972757
Pubmed

Immunohistochemical distinction of renal cell carcinoma from other carcinomas with clear-cell histomorphology: utility of CD10 and CA-125 in addition to PAX-2, PAX-8, RCCma, and adipophilin.

MUC16 PAX8

2.67e-046148225279712
Pubmed

Polyamines modulate the interaction between nuclear receptors and vitamin D receptor-interacting protein 205.

MED14 MED1

2.67e-046148212089346
Pubmed

Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies.

SLC6A2 SLC22A2

2.67e-046148215135235
Pubmed

Interdependent roles for accessory KChIP2, KChIP3, and KChIP4 subunits in the generation of Kv4-encoded IA channels in cortical pyramidal neurons.

KCND2 KCND3

2.67e-046148220943905
Pubmed

Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I(K,slow1) and I(to,f).

KCND2 KCND3

2.67e-046148218603586
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

POLR1A ACACB ANXA7 OBSCN DYSF RNFT2 SLC4A1AP ARID2 SLC25A10

2.94e-04497148936774506
Pubmed

Genetic associations of brain structural networks in schizophrenia: a preliminary study.

SLC24A5 SLC6A2 FASN

3.11e-0431148320691427
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

HCN1 UBR4 OBSCN RNF213 GPAM PRPF38B HUWE1 GFPT1 SLC5A2 SYDE2 PLXNA4

3.29e-047361481129676528
Pubmed

A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3' End Processing Complex.

HUWE1 CLP1

3.72e-047148231980388
Pubmed

Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection.

PKD1L1 PNPLA3

3.72e-047148222841784
Pubmed

Dimer-specific immunoprecipitation of active caspase-2 identifies TRAF proteins as novel activators.

TRAF1 CRADD

3.72e-047148229875129
Pubmed

Remodeling of repolarization and arrhythmia susceptibility in a myosin-binding protein C knockout mouse model.

KCND2 KCND3

3.72e-047148228646025
Pubmed

Genetic variation in the DNA repair genes is predictive of outcome in lung cancer.

APEX1 EXO1

3.72e-047148217855454
Pubmed

The DNA sequence of the human X chromosome.

SMIM10L2A TKTL1 HUWE1 NOX1 TENT5D STAG2 SMIM10L2B KLHL4

3.72e-04407148815772651
Pubmed

Reevaluating human gene annotation: a second-generation analysis of chromosome 22.

EFCAB6 HPS4 PNPLA3

3.75e-0433148312529303
Pubmed

LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.

ACACB KCND2 KCND3

4.10e-0434148326378152
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

ABCA4 ACACB ORC6 UBR4 USP24 MUC16 MED1 GFPT1 ARID2 STAG2

4.26e-046381481031182584
Pubmed

Role of the thyroid-stimulating hormone receptor signaling in development and differentiation of the thyroid gland.

SLC5A5 PAX8

4.95e-048148212432093
Pubmed

Proteomic analyses of native brain K(V)4.2 channel complexes.

KCND1 KCND2

4.95e-048148219713751
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

USP24 MED14 PRPF38B HUWE1 MED1 FASN ABCB9 SLC4A1AP EXO1 PPP1R18 STAG2

5.01e-047741481115302935
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

TPP2 EPPK1 POLR1A UBR4 USP24 HUWE1 GFPT1 FASN NNT STAG2

5.10e-046531481022586326
Pubmed

The conserved Mediator subunit cyclin C (CCNC) is required for brown adipocyte development and lipid accumulation.

GPAM CIDEA FASN

5.28e-0437148335863637
Pubmed

USP45 and Spindly are part of the same complex implicated in cell migration.

TPP2 EPPK1 FASN VCAN KCNAB3 STAG2

5.29e-04235148630258100
Pubmed

Lysine acetylation targets protein complexes and co-regulates major cellular functions.

DOK3 RNF213 PRAG1

5.71e-0438148319608861
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

EPPK1 UBR4 RNF213 HUWE1 FASN ARID2 STAG2

5.75e-04332148732786267
Pubmed

A long non-coding RNA specifically expressed in early embryos programs the metabolic balance in adult mice.

GPAM CIDEA FASN

6.17e-0439148333059001
Pubmed

Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha.

MED14 MED1

6.35e-049148214636573
Pubmed

Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins.

MED14 MED1

6.35e-049148210508170
GeneFamilySolute carriers

SLC24A5 SLC25A27 SLC35F1 SLC5A2 SLC5A5 SLC6A2 SLC9A4 SLCO1C1 SLC22A2 SLC25A10 SLC6A20 SLC25A47

2.30e-0639510212752
GeneFamilyPotassium voltage-gated channels

KCNH4 KCND1 KCND2 KCND3

7.46e-05401024274
GeneFamilyLipases|Arylacetamide deacetylase family

DAGLB PNLIPRP2 PNPLA3

2.48e-04221023464
CoexpressionAtlasdev gonad_e11.5_F_GonadVasMes_Flk_top-relative-expression-ranked_200

PNLIPRP2 MUC16 RNF213 KCND2 VCAN PLXNA4 FST KLHL4

1.52e-051611458gudmap_dev gonad_e11.5_F_GonadVasMes_Flk_200
ToppCellLA-11._Adipocyte|LA / Chamber and Cluster_Paper

ACACB GPAM CIDEA FASN NWD2 PLXNA4 PNPLA3 EPB41

1.86e-0718314883f9011976782fa8aa95cdd6f00f07a91094d411b
ToppCellCOVID-19-Heart-Adipocyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

GPAM CIDEA FASN NWD2 KCND2 PLXNA4 PNPLA3

8.20e-07153148793958bd9c951222ba5b740d1cb83fd5d78a10e1e
ToppCellLV-11._Adipocyte|World / Chamber and Cluster_Paper

ACACB GPAM CIDEA FASN NWD2 PLXNA4 PNPLA3

1.42e-0616614877e5852891714465c6228c9f955fd511ec79d0e02
ToppCellCOVID-19-Heart-Adipocyte|Heart / Disease (COVID-19 only), tissue and cell type

GPAM CLIC6 CIDEA FASN NWD2 KCND2 PNPLA3

1.60e-061691487bd39f85b48207955f80ca120a11e15a0124117b9
ToppCellRV-11._Adipocyte|World / Chamber and Cluster_Paper

ACACB GPAM CIDEA FASN NWD2 PLXNA4 PNPLA3

2.17e-061771487f0edf04930692418953e4f00a917257804ec0ffd
ToppCellRV-11._Adipocyte|RV / Chamber and Cluster_Paper

ACACB GPAM CIDEA FASN NWD2 PLXNA4 PNPLA3

2.25e-061781487278bbea5cf8f0589f71675c7a3d00679391b5253
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC24A5 MUC15 HCN1 HEPACAM2 LLGL2 NOX1 AGXT

2.43e-061801487d553aba594f5304f1c09ff9c6d49b64cd7ee7850
ToppCellRA-11._Adipocyte|RA / Chamber and Cluster_Paper

ACACB GPAM CIDEA FASN NWD2 PLXNA4 PNPLA3

2.43e-061801487d48a3d27357f7d184132a6805950f93080146b59
ToppCellmild_COVID-19_(asymptomatic)-T/NK_proliferative|World / disease group, cell group and cell class (v2)

ORC6 CRYZ NOX1 SLC25A10 SLC6A20 EXO1 PARPBP

2.61e-0618214879adf90bb2808f234d53b89ca0ae07380478204ad
ToppCellLA-11._Adipocyte|World / Chamber and Cluster_Paper

ACACB GPAM CIDEA FASN NWD2 PLXNA4 PNPLA3

2.71e-061831487b177be283e1553fb1f69a346f1ba79ad00297fa2
ToppCellRA-11._Adipocyte|World / Chamber and Cluster_Paper

ACACB GPAM CIDEA FASN NWD2 PLXNA4 PNPLA3

3.23e-0618814874dac9d636e5cad4cda540b93d4bfed6b5732c880
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

INSRR TMTC2 HEPACAM2 PIGQ SLC9A4 PAX8 NTN1

3.35e-061891487a9864873b19ab3e60acf11f288fa7275badc2e42
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb|Cerebellum / BrainAtlas - Mouse McCarroll V32

HCN1 INSRR CIDEA BHLHE22 NTN1 KCNAB3

1.07e-0514914866e9ca280a599d96f8956ef26f2a46b9484de5488
ToppCellfacs-Trachea-18m-Hematologic-lymphocytic-B_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TRAF1 DOK3 HEPACAM2 GRM5 PLEKHM1 FCRL1

1.84e-0516414864274a4f225cabf61f0fe27d8ea162b4eba612f87
ToppCellfacs-Trachea-18m-Hematologic-lymphocytic-B_cell-B_cell_of_the_trachea|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TRAF1 DOK3 HEPACAM2 GRM5 PLEKHM1 FCRL1

1.84e-051641486d62143450f59097ad4b34603a6257f897a769ead
ToppCelldroplet-Mammary_Gland-nan-21m-Epithelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBTB6 MYO9B HEPACAM2 HPS4 FDXR ZMYM1

1.90e-0516514867c771f22b58989572c939ed127e637ec28dc0dca
ToppCellLV-11._Adipocyte|LV / Chamber and Cluster_Paper

GPAM CIDEA FASN NWD2 PLXNA4 PNPLA3

2.49e-051731486c2d3fcb3de71015d03d14c63450853d2b03ffa71
ToppCellCOVID-19-kidney-PCT-S3-2|kidney / Disease (COVID-19 only), tissue and cell type

GPAM CALHM3 FASN AGXT PNPLA3 SLC25A47

2.57e-0517414865aa2fb631505600f37d2b87b02def7be139dc262
ToppCell3'-Adult-Appendix-Epithelial-mature_enterocytic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC25A27 OBSCN GPAM CLIC6 CR2 KCND1

2.74e-05176148630adf8f1638c6244586f8101c2590bb964dfae00
ToppCell3'-Adult-Appendix-Epithelial-mature_enterocytic-Colonocyte|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC25A27 OBSCN GPAM CLIC6 CR2 KCND1

2.74e-05176148623fa02d4c39e0b8faa1658116d50b6233a952ccc
ToppCellfacs-Spleen-nan-24m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRAF1 INSRR CD5 ABCB9 LMO1 CHST2

2.83e-0517714860d894a14ddbb2734557743e9efdb89cee5c26769
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Papillary_Renal_Cell_Carcinoma-8|TCGA-Kidney / Sample_Type by Project: Shred V9

MRPL2 TXNRD1 VAC14 FDXR SLC25A10 SLC6A20

3.01e-0517914868c6a84602b079bd357c66244371eb23dd9384918
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HCN1 CIDEA NWD2 BHLHE22 KCNAB3 UNC80

3.11e-0518014863d54cc767e25d91ed2203d8a03e5bf5e15f21699
ToppCellPCW_07-8.5-Neuronal-Neuronal_SCP-neuro_SCP_(0)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

SLC35F1 LMO1 KCND3 KCNK2 PLXNA4 NTN1

3.20e-051811486fad7ba168f541ac9d04edebc206f191e48bb7e99
ToppCellImmune-enucleated_erythrocyte|World / Lineage, Cell type, age group and donor

HEPACAM2 PIGQ ARL4A GMPR CHST2 EPB41

3.73e-051861486f9d5ec5cc8fd6e63bf25abe390307ec8a4a2d5a3
ToppCelldroplet-Pancreas|droplet / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PNLIPRP2 LRRC10B INSRR HEPACAM2 GMPR UNC80

3.84e-0518714865f4df092452d8672bda4059c794e099ba3f5a8fa
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC35F1 GRM5 LMO1 KCND2 VCAN NTN1

3.96e-051881486a244fcd092d5bd544e503366b1439b0fbc1ee00e
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC35F1 GRM5 LMO1 KCND2 VCAN NTN1

3.96e-051881486c8530c9ff98666c64a94683261af4288cb790a7e
ToppCell343B-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|343B / Donor, Lineage, Cell class and subclass (all cells)

STEAP4 CLIC6 HEPACAM2 SLC5A5 KCNK2 NTN1

4.08e-051891486b06471b1bebb990d5146bddfb8002401c6b099a0
ToppCell343B-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|343B / Donor, Lineage, Cell class and subclass (all cells)

STEAP4 CLIC6 HEPACAM2 SLC5A5 KCNK2 NTN1

4.08e-051891486a8246acf31f02c85421268245afb651aa8788f14
ToppCelldroplet-Liver-hepatocytes-3m-Epithelial-duct_epithelial_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRAG1 GFPT1 SLC9A4 LMO1 VANGL1 DNASE1L2

4.20e-0519014865b3f773380aef4773b70f0dbd74992d28e6586c6
ToppCelldroplet-Pancreas-Endocrine|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UBR4 INSRR HEPACAM2 GFPT1 GMPR UNC80

4.45e-0519214860dfd1e9896c34aee0f842f8de5d0e3af62a15f68
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

HEATR5A HUWE1 MED1 DTWD2 VANGL1 STAG2

4.58e-051931486abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 ERMP1 GRM5 PAX8 VCAN FST

4.58e-0519314860f2167eef8203a5659c8c72e4e77646003d64797
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Macrophage-macrophage,_alveolar-Macro_c4-DNAJB1|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MUC15 LRRC10B MUC16 CLIC6 FDXR GMPR

4.58e-051931486d59c08ee741a1ae478d196c4281ad4ad1f21a8c5
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A2 ARL4A KCND2 UNC45B BHLHE22 NTN1

4.72e-051941486e8102c8811333f04de7280b7d9b6b85cebb815ac
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UBR4 INSRR HUWE1 GFPT1 GMPR UNC80

4.72e-0519414860b023de48ed8a550d169bbe954881eb04bf4f981
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A2 ARL4A KCND2 UNC45B BHLHE22 NTN1

4.72e-0519414864b0d63babb8a46ff45731d5f82b29ccaf6c9402d
ToppCellTracheal-10x5prime-Immune_Lymphocytic-B-B_cell-B_mature|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DOK3 CR2 KCNH4 SCML4 FCRL1 CLEC17A

5.14e-051971486da175e66d0a743a1b91d46f224b5ff1d37aa5410
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA2 ERMP1 PIGQ FASN ARNT2 CHST2

5.28e-051981486a7e5de81eb7d3d23812c179a001adbaab1506596
ToppCellBiopsy_Other_PF-Epithelial-MUC5AC+_High|Biopsy_Other_PF / Sample group, Lineage and Cell type

ABCA4 MUC15 MUC16 SLC5A5 SLC9A4 NTN1

5.28e-05198148630e6177e216f66caddcd009fafef0e07369f4d8e
ToppCell5'-Adult-Distal_Rectal-Epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ABCA2 GFPT1 FASN LLGL2 NOX1 ENTPD6

5.28e-0519814869c0535099750698daac5d6b4d39fb19fecf4ffde
ToppCellParenchymal-NucSeq-Epithelial-Epi_submucosal-gland|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MUC16 STEAP4 CLIC6 SLC5A5 SLC9A4 NTN1

5.28e-051981486fab3135f03cf23a9f04f0eed543a9dc181f39f5f
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

USP24 SLC35F1 GRM5 VCAN ARNT2 UNC80

5.43e-051991486333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

USP24 SLC35F1 GRM5 VCAN ARNT2 UNC80

5.43e-05199148619a97e27a4758e794ce7246d295e112b47931a48
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

USP24 SLC35F1 GRM5 VCAN ARNT2 UNC80

5.43e-051991486e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCellMacroglial-Polydendrocytes-PDGFRA-|Macroglial / cells hierarchy compared to all cells using T-Statistic

SLC35F1 GRM5 KCND2 VCAN NTN1 UNC80

5.58e-052001486f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCellMacroglial-Polydendrocytes-PDGFRA--|Macroglial / cells hierarchy compared to all cells using T-Statistic

SLC35F1 GRM5 KCND2 VCAN NTN1 UNC80

5.58e-052001486cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCellMacroglial-Polydendrocytes-PDGFRA|Macroglial / cells hierarchy compared to all cells using T-Statistic

SLC35F1 GRM5 KCND2 VCAN NTN1 UNC80

5.58e-052001486c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCellMacroglial-Polydendrocytes-PDGFRA---|Macroglial / cells hierarchy compared to all cells using T-Statistic

SLC35F1 GRM5 KCND2 VCAN NTN1 UNC80

5.58e-0520014864fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCellMacroglial-Polydendrocytes-PDGFRA----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

SLC35F1 GRM5 KCND2 VCAN NTN1 UNC80

5.58e-052001486310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCellMacroglial-Polydendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

SLC35F1 GRM5 KCND2 VCAN NTN1 UNC80

5.58e-052001486961858738ce35db8760c8c2e136f8369bc444ccf
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c09-GZMK-FOS_l|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZBTB6 EFCAB6 CCIN VANGL1 GMPR

7.14e-051291485a60935ff9c5a841899ccfe90531533ba4c546df3
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma-3|TCGA-Brain / Sample_Type by Project: Shred V9

UBR4 HEATR5A KCND2 VCAN EPB41

8.85e-0513514853351e8b9e417397c5fa9f856184ff24ce1a27242
ToppCellPND07-28-samps-Lymphocyte-B_cell-B_cell_2|PND07-28-samps / Age Group, Lineage, Cell class and subclass

GRM5 CR2 SCML4 FCRL1 ENTPD6

9.48e-0513714852544d1256f11da6e3bad24a871b2253e0ab20d01
ToppCellPND07-28-samps-Lymphocyte-B_cell|PND07-28-samps / Age Group, Lineage, Cell class and subclass

GRM5 CR2 SCML4 FCRL1 ENTPD6

9.48e-051371485874e2eaa7846a2832f46b77c726d79f220a4a1cd
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MED1 SCML4 SYDE2 SLC22A2 DNAJB5

1.05e-041401485276b3fa924176426efb31112ed4d355407f0b218
ToppCellMegakaryocytic-erythropoietic-Erythro-cells-Erythrocyte|Erythro-cells / Lineage, cell class and subclass

HEPACAM2 ARL4A GMPR CHST2 EPB41

1.20e-0414414857fbedc65314cfb06bcc527d794b5de7858f7c5ec
DrugOrlistat, 5

DAGLB ABCA4 PNLIPRP2 GRM5 FASN LMO1 PNPLA3

1.42e-06861477CID000004599
Diseasemelanoma

UBR4 APEX1 GPAM SLC5A5 FASN C11orf68 STAG2 EPB41

2.31e-052481388C0025202
Diseaseinterleukin-2 receptor subunit alpha measurement

PRPF38B SLC6A2 NTN1

1.25e-04211383EFO_0010587
Diseasehepatocellular carcinoma, non-alcoholic steatohepatitis

DYSF PNPLA3

1.29e-0441382EFO_0000182, EFO_1001249
Diseasecongenital hypothyroidism (is_implicated_in)

SLC5A5 PAX8

1.29e-0441382DOID:0050328 (is_implicated_in)
DiseaseJT interval

OBSCN SLC35F1 KCND3 ARID2 ENTPD6 GMPR DNAJB5

1.73e-042481387EFO_0007885
Diseaseresponse to opioid

MUC16 CLIC6 GRM5 NNT

1.94e-04611384EFO_0008541
Diseasemuscular disease (implicated_via_orthology)

ACACB FASN

2.15e-0451382DOID:0080000 (implicated_via_orthology)
Diseasefatty acid measurement

DMGDH ABCA4 ACACB GPAM PRAG1 CD5 SLC22A2 PLXNA4 PNPLA3

2.21e-044361389EFO_0005110
Diseaseasthma

TRAF1 MYO9B MUC16 TMTC2 HEATR5A ERMP1 MED1 DYSF PRAG1 SLC9A4 NSUN3 BTNL2

2.22e-0475113812MONDO_0004979
DiseaseObesity

ACACB GFPT1 CIDEA FASN SLC22A2 ENTPD6

4.20e-042051386C0028754
Diseaseglycine measurement

ERMP1 GRM5 LMO1 SLC22A2 UNC80

4.74e-041371385EFO_0009767
DiseaseMalignant neoplasm of breast

ABCA4 MAN2C1 UBR4 OBSCN MED14 HEPACAM2 DYSF SLC5A5 FASN NLRP14 LLGL2 UNC45B EXO1 FST

5.26e-04107413814C0006142
DiseaseX-linked infantile spasms

HCN1 PIGQ

5.97e-0481382C4552072
DiseaseSudden Cardiac Arrest

KCND2 KCND3

5.97e-0481382C1720824
Diseasehair colour measurement, eye colour measurement, skin pigmentation measurement

SLC24A5 GRM5

9.53e-04101382EFO_0007009, EFO_0007822, EFO_0009764
Diseaseglutamine measurement

LMO1 SLC6A20 PNPLA3 SLC25A47

1.13e-03971384EFO_0009768
Diseasemetabolite measurement

SLC24A5 DMGDH PNLIPRP2 GPAM SLC22A2 SLC6A20 PNPLA3 ZMYM1 DHTKD1

1.32e-035601389EFO_0004725
Diseasehippocampal CA1 volume

RNFT2 VCAN NTN1

1.48e-03481383EFO_0009394
DiseaseEpilepsy

HCN1 TXNRD1 PIGQ KCND2

1.74e-031091384C0014544
DiseaseIGF-1 measurement

ACACB CRADD GRM5 TXNRD1 TRIM66 PAX8 SLC22A2 PARPBP

2.16e-034881388EFO_0004627
DiseaseOpioid use measurement

NLRP7 KCND3

2.19e-03151382EFO_0009937
DiseaseP wave duration

HCN1 KCND3

2.19e-03151382EFO_0005094
Diseaseatopic asthma

TRAF1 ERMP1 MED1 SLC9A4 BTNL2

2.49e-031991385EFO_0010638
Diseasevery low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio

DMGDH ACACB USP24 GPAM SLC22A2 PNPLA3

2.53e-032911386EFO_0008317, EFO_0020946
Diseasecholesterol:total lipids ratio, intermediate density lipoprotein measurement

DMGDH GPAM SLC22A2 PNPLA3

2.55e-031211384EFO_0008595, EFO_0020943
DiseaseLiver carcinoma

APEX1 MED1 SLC5A5 FASN ARID2 EXO1 SLC25A47 FST

2.73e-035071388C2239176
Diseaset-tau measurement

DMGDH DTWD2 PLXNA4 FST

2.95e-031261384EFO_0004760
Diseasenon-alcoholic fatty liver disease (biomarker_via_orthology)

ACACB GPAM FASN

3.54e-03651383DOID:0080208 (biomarker_via_orthology)
Diseaseeye colour measurement

SLC24A5 NWD2 FCRL1 CLEC17A ARNT2

3.68e-032181385EFO_0009764
Diseasecoronary artery disease

DAGLB PNLIPRP2 MYO9B HCN1 LRRC10B DOK3 RNF213 SLC35F1 SCML4 OSM SLC22A2 AGXT PNPLA3

4.04e-03119413813EFO_0001645
Diseaseforced expiratory volume

DMGDH CRADD GMPR2 MED1 PLEKHM1 SLC9A4 LLGL2 KCNK2 PLXNA4 NNT

4.06e-0378913810EFO_0004314
Diseasetriglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement

DMGDH USP24 GPAM SLC22A2 PNPLA3

4.21e-032251385EFO_0008317, EFO_0020947
Diseasesaturated fatty acids to total fatty acids percentage

GPAM PNPLA3

4.30e-03211382EFO_0022305
Diseasephospholipids:total lipids ratio

DMGDH USP24 GPAM SLC22A2 PNPLA3

4.37e-032271385EFO_0020946

Protein segments in the cluster

PeptideGeneStartEntry
DCKRYLGLTVASFLG

VANGL1

106

Q8TAA9
IILGVCSSGLLVYKD

EPB41

411

P11171
VLYSALISLKEALCG

DNAJB5

261

O75953
TVVKLLASDAGLYRC

VCAN

116

P13611
CSLLVYQRKGALLDS

CCIN

266

Q13939
KSLGLTVYADCLAGT

ABCA4

2056

P78363
YCGETSLLLKVAGLG

BTNL2

131

Q9UIR0
LLSCSKLGYISRVTA

ALS2

661

Q96Q42
LSSLPAGAALCLKYG

BHLHE22

116

Q8NFJ8
LPCGLVLSSIGYKSR

FDXR

351

P22570
GICLLLAAVTVKLYS

CALHM3

21

Q86XJ0
LARGGILTSTGFYKC

ARID2

556

Q68CP9
LGLDCAGKTTVLYRL

ARL4A

26

P40617
TLYLLGMLVASCLGR

CD5

11

P06127
GYVESGLKTILQCAL

ANXA7

401

P20073
VGLLSRQCPLKVSYG

APEX1

131

P27695
RGRSSLYCSDIGKLV

DHTKD1

376

Q96HY7
GILALYSGLSASLCR

SLC25A10

56

Q9UBX3
LTALGCSRIAIKKYL

CLIC6

461

Q96NY7
TVCRKSGTLILYPGA

DTWD2

141

Q8NBA8
YKKDFLCGLGITLIS

ERMP1

446

Q7Z2K6
GSLCVLLSLGKKRDY

CACNG1

121

Q06432
GSKYCLVAIGRLQVT

ARNT2

306

Q9HBZ2
LTRCGKTDDLLYGII

NWD2

841

Q9ULI1
LYKLSGRKSGGVCLN

NTN1

356

O95631
LRVSHGCVSKILGRY

PAX8

51

Q06710
CQIARAYGLKILGTA

CRYZ

166

Q08257
AYCGRDTVKALLVLL

PARPBP

346

Q9NWS1
VGSTLYTKANLILCR

LMO1

61

P25800
VTCRAIGIGAYLVRL

ACACB

1931

O00763
YTRKILGSTLACARA

NOX1

41

Q9Y5S8
KNTSVGLLYSGCRLT

MUC16

12896

Q8WXI7
IKALRPGGILVYSTC

NSUN3

251

Q9H649
GLRILGYTLKSCASE

KCND1

311

Q9NSA2
GLRILGYTLKSCASE

KCND3

306

Q9UK17
KSSSRELCYIILAGI

GRM5

611

P41594
DASGVCLRLLYKLST

LLGL2

451

Q6P1M3
SLLTLVGYLLCGKRK

MUC15

251

Q8N387
AGCILYKGLIVSTQL

HPS4

191

Q9NQG7
RTEGGKIFCIIYALL

KCNK2

166

O95069
RLIACGSLYQGICKL

PLXNA4

126

Q9HCM2
QYALTCLRKVTGLGG

KSR1

161

Q8IVT5
DITKLSLRLCTGNLY

PNPLA3

206

Q9NST1
LVDCGIGYSKLRVIL

PRAMEF18

356

Q5VWM3
LTGYLLRASAICSKL

RASGRP4

521

Q8TDF6
LRATKLYRGSLIALC

DPY19L1

231

Q2PZI1
RILGYTLKSCASELG

KCND2

311

Q9NZV8
EYKVASVGGSRCLLL

KCNH4

206

Q9UQ05
LASGLYASVCKRASG

DOK3

376

Q7L591
CALSRLQKLYVSGTG

LRRC10B

41

A6NIK2
GIRSTCTYVGAAKLK

GMPR2

311

Q9P2T1
RKATCLLGRSIGLAY

FST

221

P19883
LLGRSIGLAYEGKCI

FST

226

P19883
GYTLCKQIGTLLAEL

HUWE1

3631

Q7Z6Z7
KLYAIGGRDGSSCLK

KLHL4

571

Q9C0H6
RKLILCYGTTKGSSI

MED14

806

O60244
KGLVRLSRCYAGLSG

OBSCN

7881

Q5VST9
SYFGEICLLTKGRRT

HCN1

536

O60741
VVCLGSLYKKLGRIL

HEATR5A

116

Q86XA9
GYLLVGEKIINCLSS

CR2

186

P20023
ACGSIIAKILAGYDL

DNASE1L2

41

Q92874
KALSRLADLGYGCGT

C5orf24

146

Q7Z6I8
GSGRILYKKLLACIG

EFCAB6

556

Q5THR3
KLDCAGGALLSSYLI

DAGLB

46

Q8NCG7
TVALLFCYGLKRKIG

FCRL1

321

Q96LA6
LSLGLSQTDIYRCKA

CRADD

136

P78560
LYSKAKLASACGGII

ABCA2

806

Q9BZC7
ALAAGARKCGALLKY

DMGDH

201

Q9UI17
CKYGASVRGSILSLS

MAN2C1

871

Q9NTJ4
TVLCVSRLRYAKFGG

INSRR

861

P14616
IYLLLFGACSGLKVT

HEPACAM2

21

A8MVW5
GLRSTCTYVGAAKLK

GMPR

311

P36959
GYCRSEGVVAVLLTK

FASN

221

P49327
RGIALQLCKAGATVY

DHRS1

21

Q96LJ7
GGYLRLSRSCLAKGS

PPP1R18

516

Q6NYC8
SIGYIADRFGRKLCL

SLC22A2

166

O15244
AGARGYLKTSLCVLG

DYSF

331

O75923
ALGGKCYLIGSSVIR

PKD1L1

2366

Q8TDX9
LSAELYCRAGSLILK

CAMSAP2

76

Q08AD1
AYNTLIGSCVKRTIL

MED1

416

Q15648
LLATVRGKEVCYGQL

PNLIPRP2

11

P54317
GILLTVGAAYLCKCL

ICAM4

251

Q14773
PLACGLITSKYDGRV

KCNAB3

286

O43448
LALGLYCGRAKPVAT

NRAC

116

Q8N912
SIIITPGYGLCAAKA

NNT

926

Q13423
FLGGVLIVLYSLCKS

RNFT2

331

Q96EX2
YLGLCRSGALKELSK

PLEKHM1

931

Q9Y4G2
TLLCKAYRGGHLTIR

MRPS16

6

Q9Y3D3
GLYRLCGSAAVKKEL

SYDE2

851

Q5VT97
LALFCITKGGIYVLT

SLC6A2

456

P23975
LAACSIALGKDSGLY

VAC14

76

Q08AM6
YKCLLLVDSVASLGG

AGXT

176

P21549
AVIYATKGITRCLLN

POLR1A

1551

O95602
GSLRVAKVAYPLGLC

ENTPD6

36

O75354
LRYCKERGALTVGIT

GFPT1

451

Q06210
IACSLYAVLNKRGLG

GPAM

586

Q9HCL2
GARLYCLKIHGLSSL

PIGQ

406

Q9BRB3
VKRYLEGTSCIAGVL

EPPK1

2216

P58107
VKRYLEGTSCIAGVL

EPPK1

4351

P58107
IRGGGLLKYCSLLVH

TENT5D

231

Q8NEK8
LGIGLSLYLICQVKA

SLC9A4

171

Q6AI14
GSYGAFCKGLTRTLL

SMIM10L2A

31

P0DMW4
GSYGAFCKGLTRTLL

SMIM10L2B

31

P0DMW5
LRVYCALLAGKAAVL

SHROOM1

786

Q2M3G4
CGLYKGSSALVLRDG

SLC25A47

176

Q6Q0C1
SITKLGCRYLSEALQ

NLRP7

886

Q8WX94
EYLRLSRVKCVGLSA

ORC6

26

Q9Y5N6
YLSSLRGIGLAKACK

EXO1

226

Q9UQ84
AAIGSCSKEYRVLLG

OSM

26

P13725
VYLCILRGTESTGKV

SLC6A20

181

Q9NP91
YRSCLLLGATIGVAK

ABCB9

56

Q9NP78
ALFGLLVYLAGAKCT

CLDN6

91

P56747
SVSYDIRCTGLKGLL

CIDEA

156

O60543
GKSTVCRLLLNYAVR

CLP1

126

Q92989
FRRKALVLCAGYALL

CHST2

51

Q9Y4C5
LFLGCLGLTVTLIKY

CLEC17A

181

Q6ZS10
SAIRAAGIKCLLTYK

C11orf68

231

Q9H3H3
SLLICGIGLTSKYLS

SLC35F1

71

Q5T1Q4
RLLAQRLYAGSTVKC

TXNRD1

501

Q16881
CLTLGSLGHKVYSLL

RNF213

1881

Q63HN8
LLATLYRNRAACGLK

UNC45B

41

Q8IWX7
SCARLVRAIKLLYGD

UNC80

1491

Q8N2C7
GLLSISAFACSYLGK

TAS1R1

736

Q7RTX1
SLTHIKAGCILCGYL

SLC5A2

306

P31639
ISKGLSLIYGSACLT

SLC5A5

386

Q92911
GEVRLKCLTALQGLY

STAG2

341

Q8N3U4
TGGIVSTAFCLLYKL

PRPF38B

121

Q5VTL8
SKYLAFTCGLIRGGL

TRAPPC6B

116

Q86SZ2
FCLLITVGARALYVK

TMTC2

431

Q8N394
CLTLYTGRGGDLQKI

NABP2

81

Q9BQ15
LLGSLCAKLYVDIGF

SLCO1C1

241

Q9NYB5
KFRISVCGAAKLYLG

SLCO1C1

416

Q9NYB5
GCYLAGSLTLSKTEL

TPP2

966

P29144
RGLLYKSSTDCLIQA

SLC25A27

266

O95847
GASLLTSGLELYCQK

TEX101

16

Q9BY14
KLGIVCLLSYLGLAT

SLC24A5

466

Q71RS6
YIRAAGTCGVLLRKV

MRPL2

206

Q5T653
CLRLYLNGDGTGKRT

TRAF1

306

Q13077
LILCTAHTLVYGGKR

STEAP4

391

Q687X5
GGLYTQSLARLVAKC

PRAG1

956

Q86YV5
RGSYGAFCKTLTRTL

SMIM10

36

Q96HG1
GKCLLASTYLARLGL

USP24

151

Q9UPU5
CSSLLRKHQIIYLGG

ZNF860

241

A6NHJ4
CLKFLYRVLSVTGIL

ZMYM1

861

Q5SVZ6
YVRLERLKICAASSG

TRIM66

861

O15016
RLVGTVLNGYLCLRK

UBR4

4261

Q5T4S7
SIGYVLRFLAKLCRS

SCML4

181

Q8N228
TRKACGLALAKLGYA

TKTL1

291

P51854
GRKLLLSCYTGALEV

ZBTB6

81

Q15916
GCEYLSLALISNKRL

NLRP14

831

Q86W24
TILGTRSLKGTSYCL

SLC4A1AP

176

Q9BWU0
RSLKGTSYCLFGRLS

SLC4A1AP

181

Q9BWU0
AIASLRLDGTKCYVL

MYO9B

51

Q13459