Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ribosylnicotinate kinase activity	NMRK1 NMRK2	3.34e-06	2	37	2	GO:0061769
GeneOntologyMolecularFunction	ribosylnicotinamide kinase activity	NMRK1 NMRK2	1.00e-05	3	37	2	GO:0050262
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	CHD4 CHD5 RSF1	4.36e-05	37	37	3	GO:0140658
GeneOntologyMolecularFunction	cAMP-dependent protein kinase activity	PRKX PRKY	6.97e-05	7	37	2	GO:0004691
GeneOntologyMolecularFunction	cyclic nucleotide-dependent protein kinase activity	PRKX PRKY	1.19e-04	9	37	2	GO:0004690
GeneOntologyMolecularFunction	nuclear import signal receptor activity	IPO5 RANBP6	6.22e-04	20	37	2	GO:0061608
GeneOntologyMolecularFunction	nuclear localization sequence binding	IPO5 RANBP6	1.14e-03	27	37	2	GO:0008139
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	NMRK1 PRKDC NMRK2 MTOR PRKX PRKY TIPARP	1.48e-03	938	37	7	GO:0016772
GeneOntologyMolecularFunction	nucleocytoplasmic carrier activity	IPO5 RANBP6	1.60e-03	32	37	2	GO:0140142
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	CHD4 CHD5 RSF1	1.67e-03	127	37	3	GO:0008094
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	NMRK1 PRKDC NMRK2 MTOR PRKX PRKY	1.78e-03	709	37	6	GO:0016773
GeneOntologyMolecularFunction	kinase activity	NMRK1 PRKDC NMRK2 MTOR PRKX PRKY	2.59e-03	764	37	6	GO:0016301
GeneOntologyMolecularFunction	gated channel activity	SCN10A SCNN1G GRIN2C KCNK17	3.29e-03	334	37	4	GO:0022836
GeneOntologyMolecularFunction	monoatomic cation channel activity	SCN10A SCNN1G GRIN2C KCNK17	3.61e-03	343	37	4	GO:0005261
GeneOntologyMolecularFunction	signal sequence binding	IPO5 RANBP6	4.02e-03	51	37	2	GO:0005048
GeneOntologyMolecularFunction	sodium channel activity	SCN10A SCNN1G	4.18e-03	52	37	2	GO:0005272
GeneOntologyMolecularFunction	protein serine kinase activity	PRKDC MTOR PRKX PRKY	4.42e-03	363	37	4	GO:0106310
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	SCN10A GRIN2C KCNK17	4.61e-03	182	37	3	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	SCN10A GRIN2C KCNK17	4.75e-03	184	37	3	GO:0022832
GeneOntologyCellularComponent	T cell receptor complex	TRBV27 TRBV25-1 TRB TRBV6-4	2.62e-04	163	40	4	GO:0042101
GeneOntologyCellularComponent	NuRD complex	CHD4 CHD5	4.77e-04	17	40	2	GO:0016581
GeneOntologyCellularComponent	CHD-type complex	CHD4 CHD5	4.77e-04	17	40	2	GO:0090545
GeneOntologyCellularComponent	plasma membrane signaling receptor complex	TRBV27 TRBV25-1 GRIN2C TRB TRBV6-4	5.20e-04	350	40	5	GO:0098802
GeneOntologyCellularComponent	plasma membrane protein complex	SCN10A CDH23 TRBV27 TRBV25-1 GRIN2C TRB TRBV6-4	6.47e-04	785	40	7	GO:0098797
GeneOntologyCellularComponent	SWI/SNF superfamily-type complex	CHD4 CHD5 RSF1	8.20e-04	96	40	3	GO:0070603
GeneOntologyCellularComponent	sodium channel complex	SCN10A SCNN1G	1.40e-03	29	40	2	GO:0034706
GeneOntologyCellularComponent	membrane protein complex	SCN10A SCNN1G CDH23 TRBV27 TRBV25-1 GRIN2C KCNK17 TRB TRBV6-4	1.75e-03	1498	40	9	GO:0098796
GeneOntologyCellularComponent	ATPase complex	CHD4 CHD5 RSF1	1.92e-03	129	40	3	GO:1904949
GeneOntologyCellularComponent	endoplasmic reticulum-Golgi intermediate compartment	MAN1A1 FN1 CNIH1	2.47e-03	141	40	3	GO:0005793
MousePheno	abnormal cardiac jelly morphology	CHD4 FN1	2.15e-05	4	27	2	MP:0009382
Domain	HEAT	IPO5 RANBP6 PRKDC MTOR	4.58e-06	58	36	4	IPR000357
Domain	HEAT_REPEAT	IPO5 RANBP6 PRKDC MTOR	9.73e-06	70	36	4	PS50077
Domain	CHDCT2	CHD4 CHD5	1.08e-05	3	36	2	PF08074
Domain	CHDNT	CHD4 CHD5	1.08e-05	3	36	2	PF08073
Domain	DUF1086	CHD4 CHD5	1.08e-05	3	36	2	IPR009462
Domain	DUF1087	CHD4 CHD5	1.08e-05	3	36	2	IPR009463
Domain	DUF1087	CHD4 CHD5	1.08e-05	3	36	2	PF06465
Domain	DUF1086	CHD4 CHD5	1.08e-05	3	36	2	PF06461
Domain	DUF1087	CHD4 CHD5	1.08e-05	3	36	2	SM01147
Domain	DUF1086	CHD4 CHD5	1.08e-05	3	36	2	SM01146
Domain	CHD_N	CHD4 CHD5	1.08e-05	3	36	2	IPR012958
Domain	CHD_C2	CHD4 CHD5	1.08e-05	3	36	2	IPR012957
Domain	FATC	PRKDC MTOR	3.60e-05	5	36	2	PF02260
Domain	FAT	PRKDC MTOR	5.39e-05	6	36	2	PF02259
Domain	PIK-rel_kinase_FAT	PRKDC MTOR	5.39e-05	6	36	2	IPR003151
Domain	FATC_dom	PRKDC MTOR	5.39e-05	6	36	2	IPR003152
Domain	PIK_FAT	PRKDC MTOR	5.39e-05	6	36	2	IPR014009
Domain	FAT	PRKDC MTOR	5.39e-05	6	36	2	PS51189
Domain	FATC	PRKDC MTOR	5.39e-05	6	36	2	PS51190
Domain	FATC	PRKDC MTOR	5.39e-05	6	36	2	SM01343
Domain	-	IPO5 RANBP6 PRKDC WDFY3 MTOR	6.33e-05	222	36	5	1.25.10.10
Domain	HEAT	IPO5 RANBP6 PRKDC	1.07e-04	48	36	3	PF02985
Domain	ARM-like	IPO5 RANBP6 PRKDC WDFY3 MTOR	1.59e-04	270	36	5	IPR011989
Domain	Znf_FYVE_PHD	CHD4 WDFY3 CHD5 RSF1	1.78e-04	147	36	4	IPR011011
Domain	Zinc_finger_PHD-type_CS	CHD4 CHD5 RSF1	2.65e-04	65	36	3	IPR019786
Domain	PI3/4_kinase_CS	PRKDC MTOR	3.73e-04	15	36	2	IPR018936
Domain	PHD	CHD4 CHD5 RSF1	4.04e-04	75	36	3	PF00628
Domain	PI3Kc	PRKDC MTOR	4.26e-04	16	36	2	SM00146
Domain	-	PRKDC MTOR	4.26e-04	16	36	2	1.10.1070.11
Domain	ARM-type_fold	IPO5 RANBP6 PRKDC WDFY3 MTOR	4.54e-04	339	36	5	IPR016024
Domain	Znf_PHD-finger	CHD4 CHD5 RSF1	4.70e-04	79	36	3	IPR019787
Domain	PI3_4_KINASE_1	PRKDC MTOR	5.42e-04	18	36	2	PS00915
Domain	PI3_4_KINASE_2	PRKDC MTOR	5.42e-04	18	36	2	PS00916
Domain	PI3/4_kinase_cat_dom	PRKDC MTOR	5.42e-04	18	36	2	IPR000403
Domain	PI3_PI4_kinase	PRKDC MTOR	5.42e-04	18	36	2	PF00454
Domain	PI3_4_KINASE_3	PRKDC MTOR	5.42e-04	18	36	2	PS50290
Domain	PHD	CHD4 CHD5 RSF1	6.67e-04	89	36	3	SM00249
Domain	Znf_PHD	CHD4 CHD5 RSF1	7.11e-04	91	36	3	IPR001965
Domain	ZF_PHD_2	CHD4 CHD5 RSF1	8.06e-04	95	36	3	PS50016
Domain	ZF_PHD_1	CHD4 CHD5 RSF1	8.31e-04	96	36	3	PS01359
Domain	Chromo_domain	CHD4 CHD5	9.71e-04	24	36	2	IPR023780
Domain	Chromo	CHD4 CHD5	1.14e-03	26	36	2	PF00385
Domain	CHROMO_2	CHD4 CHD5	1.32e-03	28	36	2	PS50013
Domain	CHROMO_1	CHD4 CHD5	1.32e-03	28	36	2	PS00598
Domain	-	TRIM69 CHD4 WDFY3 CHD5 RSF1	1.60e-03	449	36	5	3.30.40.10
Domain	Alkaline_phosphatase_core	SULF1 ENPP2	1.62e-03	31	36	2	IPR017850
Domain	Alkaline_Pase-like_a/b/a	SULF1 ENPP2	1.62e-03	31	36	2	IPR017849
Domain	-	SULF1 ENPP2	1.62e-03	31	36	2	3.40.720.10
Domain	SNF2_N	CHD4 CHD5	1.73e-03	32	36	2	PF00176
Domain	SNF2_N	CHD4 CHD5	1.73e-03	32	36	2	IPR000330
Domain	Chromodomain-like	CHD4 CHD5	1.73e-03	32	36	2	IPR016197
Domain	Znf_RING/FYVE/PHD	TRIM69 CHD4 WDFY3 CHD5 RSF1	1.76e-03	459	36	5	IPR013083
Domain	CHROMO	CHD4 CHD5	1.84e-03	33	36	2	SM00298
Domain	Chromo/shadow_dom	CHD4 CHD5	1.84e-03	33	36	2	IPR000953
Domain	DNA/RNA_helicase_DEAH_CS	CHD4 CHD5	2.07e-03	35	36	2	IPR002464
Domain	DEAH_ATP_HELICASE	CHD4 CHD5	2.43e-03	38	36	2	PS00690
Domain	HMG_box_dom	CHD4 CHD5	6.96e-03	65	36	2	IPR009071
Pathway	WP_DYSREGULATED_MIRNA_TARGETING_IN_INSULINPI3KAKT_SIGNALING	MTOR PRKX PRKY	2.48e-05	28	29	3	MM15957
Pubmed	Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection.	NMRK1 NMRK2	1.29e-06	2	40	2	34403688
Pubmed	Nicotinamide riboside kinase structures reveal new pathways to NAD+.	NMRK1 NMRK2	1.29e-06	2	40	2	17914902
Pubmed	The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability.	PRKX PRKY	1.29e-06	2	40	2	7633447
Pubmed	Dual TORK/DNA-PK inhibition blocks critical signaling pathways in chronic lymphocytic leukemia.	PRKDC MTOR	1.29e-06	2	40	2	27235137
Pubmed	Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells.	NMRK1 NMRK2	1.29e-06	2	40	2	28752046
Pubmed	Man to mouse--lessons learned from the distal end of the human X chromosome.	PRKX PRKY	1.29e-06	2	40	2	9414316
Pubmed	Profiles of PrKX expression in developmental mouse embryo and human tissues.	PRKX PRKY	1.29e-06	2	40	2	15879576
Pubmed	DNA-PK, Nuclear mTOR, and the Androgen Pathway in Prostate Cancer.	PRKDC MTOR	1.29e-06	2	40	2	32209447
Pubmed	Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans.	NMRK1 NMRK2	1.29e-06	2	40	2	15137942
Pubmed	PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation.	PRKX PRKY	1.29e-06	2	40	2	21684272
Pubmed	Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females.	PRKX PRKY	1.29e-06	2	40	2	9302280
Pubmed	Nicotinamide riboside kinases regulate skeletal muscle fiber-type specification and are rate-limiting for metabolic adaptations during regeneration.	NMRK1 NMRK2	1.29e-06	2	40	2	36438552
Pubmed	A novel murine PKA-related protein kinase involved in neuronal differentiation.	PRKX PRKY	1.29e-06	2	40	2	10729225
Pubmed	Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency.	PRKX PRKY	3.87e-06	3	40	2	17980165
Pubmed	FISH localization of the human Y-homolog of protein kinase PRKX (PRKY) to Yp11.2 and two pseudogenes to 15q26 and Xq12-->q13.	PRKX PRKY	3.87e-06	3	40	2	9154127
Pubmed	Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva.	MTOR ENPP2	3.87e-06	3	40	2	28758906
Pubmed	Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model.	GRIN2C MTOR	3.87e-06	3	40	2	25081057
Pubmed	The complete 685-kilobase DNA sequence of the human beta T cell receptor locus.	TRBV27 TRBV25-1 TRB TRBV6-4	4.43e-06	95	40	4	8650574
Pubmed	mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes.	PRKDC MTOR	7.73e-06	4	40	2	16221682
Pubmed	Over-expression of DNA-PKcs in renal cell carcinoma regulates mTORC2 activation, HIF-2α expression and cell proliferation.	PRKDC MTOR	7.73e-06	4	40	2	27412013
Pubmed	A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation.	CHD4 CHD5 RSF1	9.80e-06	36	40	3	29089422
Pubmed	The TIP60 Complex Is a Conserved Coactivator of HIF1A.	IPO5 PRKDC MTOR BDH1	1.12e-05	120	40	4	27320910
Pubmed	DNA double-strand breaks relieve USF-mediated repression of Dβ2 germline transcription in developing thymocytes.	PRKDC TRB	1.29e-05	5	40	2	22287717
Pubmed	Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.	PRKDC MTOR	2.70e-05	7	40	2	24011591
Pubmed	A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.	PRKDC MTOR	3.60e-05	8	40	2	20810650
Pubmed	Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing.	PRKX PRKY	3.60e-05	8	40	2	22641646
Pubmed	Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney.	SCNN1G MTOR	5.77e-05	10	40	2	21413931
Pubmed	Tel2 regulates the stability of PI3K-related protein kinases.	PRKDC MTOR	5.77e-05	10	40	2	18160036
Pubmed	Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.	PRKDC MTOR	7.05e-05	11	40	2	20427287
Pubmed	Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage.	IPO5 PRKDC	7.05e-05	11	40	2	15758953
Pubmed	The NuRD chromatin-remodeling enzyme CHD4 promotes embryonic vascular integrity by transcriptionally regulating extracellular matrix proteolysis.	CHD4 FN1	7.05e-05	11	40	2	24348274
Pubmed	CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity.	CHD4 FN1	8.45e-05	12	40	2	27140400
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	IPO5 PRKDC TRIM64C MTOR	8.57e-05	202	40	4	33005030
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	IPO5 CHD4 PRKDC FN1 MTOR RSF1	9.55e-05	653	40	6	22586326
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	SCN10A SCNN1G	9.98e-05	13	40	2	15123669
Pubmed	DLX1 and the NuRD complex cooperate in enhancer decommissioning and transcriptional repression.	CHD4 CHD5	1.34e-04	15	40	2	35695185
Pubmed	Satb2 is required for the regionalization of retrosplenial cortex.	MAN1A1 FN1	1.34e-04	15	40	2	31666685
Pubmed	The chromatin remodeling factor CHD5 is a transcriptional repressor of WEE1.	CHD4 CHD5	1.34e-04	15	40	2	25247294
Pubmed	A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development.	CHD4 CHD5	1.73e-04	17	40	2	27806305
Pubmed	Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.	PRKDC MTOR	2.18e-04	19	40	2	20801936
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	CHD4 CHD5 RSF1	2.30e-04	103	40	3	32744500
Pubmed	Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.	IPO5 CHD4 PRKDC	2.50e-04	106	40	3	19394292
Pubmed	NMRK2 Gene Is Upregulated in Dilated Cardiomyopathy and Required for Cardiac Function and NAD Levels during Aging.	NMRK1 NMRK2	2.67e-04	21	40	2	33805532
Pubmed	Gain-of-Function MN1 Truncation Variants Cause a Recognizable Syndrome with Craniofacial and Brain Abnormalities.	PRKDC PRC1	2.94e-04	22	40	2	31839203
Pubmed	IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice.	CDH23 PRKDC	3.21e-04	23	40	2	34473953
Pubmed	The functional interactome landscape of the human histone deacetylase family.	IPO5 CHD4 PRKDC BDH1	3.37e-04	289	40	4	23752268
Pubmed	Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46.	MAN1A1 FN1	3.50e-04	24	40	2	15308636
Pubmed	5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.	RANBP6 MTOR	4.45e-04	27	40	2	23027611
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	IPO5 CHD4 PRKDC	4.46e-04	129	40	3	23022380
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	SCN10A CHD4 PRKDC FN1	5.07e-04	322	40	4	26514267
Pubmed	Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.	SULF1 ENPP2	5.13e-04	29	40	2	21998595
Pubmed	UBR-box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target.	PRKDC MTOR	5.50e-04	30	40	2	32867711
Pubmed	Identification of molecules preferentially expressed beneath the marginal zone in the developing cerebral cortex.	CHD4 FN1	5.50e-04	30	40	2	18055048
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	IPO5 CHD4 PRKDC WDFY3 FN1 SULF1 ENPP2	5.92e-04	1285	40	7	35914814
Pubmed	Zbtb20 is essential for the specification of CA1 field identity in the developing hippocampus.	MAN1A1 FN1	6.26e-04	32	40	2	20308569
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	IPO5 MRPL57 CHD4 PRKDC PRC1 CHD5	7.06e-04	949	40	6	36574265
Pubmed	Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex.	GRIN2C MTOR	7.49e-04	35	40	2	35858542
Pubmed	Identification of the BRD1 interaction network and its impact on mental disorder risk.	CHD4 CHD5	7.49e-04	35	40	2	27142060
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	CDH23 RXFP1 PRKDC HNMT	7.77e-04	361	40	4	26167880
Pubmed	Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.	CHD4 CHD5	8.83e-04	38	40	2	33283408
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	IPO5 RANBP6 CHD4 PRKDC MTOR	9.02e-04	657	40	5	36180527
Pubmed	Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma.	PRKDC FN1	9.79e-04	40	40	2	29180744
Pubmed	The conserved Tpk1 regulates non-homologous end joining double-strand break repair by phosphorylation of Nej1, a homolog of the human XLF.	CHD4 PRKDC	1.08e-03	42	40	2	34244791
Interaction	H2AZ1 interactions	CHD4 PRKDC PRC1 BAHD1 PRKX DNAH1 RSF1	4.33e-06	371	37	7	int:H2AZ1
Interaction	NBN interactions	IPO5 PRKDC MTOR PRKY TIPARP	2.01e-05	183	37	5	int:NBN
Cytoband	7q34	TRBV27 TRBV25-1 TRB TRBV6-4	1.39e-05	167	40	4	7q34
Cytoband	Ensembl 112 genes in cytogenetic band chr7q34	TRBV27 TRBV25-1 TRBV6-4	5.70e-04	185	40	3	chr7q34
Cytoband	3p21.1	NT5DC2 DNAH1	6.23e-04	42	40	2	3p21.1
GeneFamily	T cell receptor beta locus at 7q34	TRBV27 TRBV25-1 TRB TRBV6-4	8.07e-06	87	27	4	372
GeneFamily	PHD finger proteins\|NuRD complex	CHD4 CHD5	1.40e-04	12	27	2	1305
GeneFamily	PHD finger proteins	CHD4 CHD5 RSF1	3.20e-04	90	27	3	88
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM69 TRIM64C	8.80e-03	95	27	2	59
Coexpression	TRAVAGLINI_LUNG_ARTERY_CELL	FN1 PRKX SULF1 ENPP2 TIPARP	1.27e-06	131	38	5	M41662
Coexpression	PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP	WDFY3 FN1 HNMT SULF1 ENPP2	1.30e-05	211	38	5	M12225
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_progenitors-Cycling_pre-Myeloid-2\|lymph-node_spleen / Manually curated celltypes from each tissue	WDFY3 PRC1 HNMT NT5DC2	1.73e-05	173	40	4	783b8fa08b9d8f597f251793eae164151662f1f9
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAN1A1 MTOR BDH1 TIPARP	1.89e-05	177	40	4	c6812679aa6522d03bd29144e71c5fae6a92325e
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-Plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAN1A1 MTOR BDH1 TIPARP	1.89e-05	177	40	4	ff97398d2adb83063b7c53a264bfae86ea7ea304
ToppCell	droplet-Marrow-nan-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHD4 FN1 PRKX RSF1	2.25e-05	185	40	4	7adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell	367C-Endothelial_cells-Endothelial-B_(Artery)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	FN1 PRKX ENPP2 TIPARP	2.25e-05	185	40	4	b57dae20c21f984edd2acee4344d86f033108ebf
ToppCell	367C-Endothelial_cells-Endothelial-B_(Artery)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	FN1 PRKX ENPP2 TIPARP	2.25e-05	185	40	4	d3b054d203e575c1bb5455aa7a2e551a0957a760
ToppCell	facs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MAN1A1 FN1 SULF1 ENPP2	2.40e-05	188	40	4	aa516273cdde53c8c0295f06830972388f890c97
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-Pericytes-angiogenic_pericyte\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RXFP1 FN1 HNMT NT5DC2	2.45e-05	189	40	4	d0c7549be4f77520c23dddf4f94d0fcad0081e37
ToppCell	COPD-Endothelial-VE_Arterial\|Endothelial / Disease state, Lineage and Cell class	PRKX SULF1 ENPP2 TIPARP	2.55e-05	191	40	4	ef16ad1c1cd2c0c0377957398c98775b62a81754
ToppCell	10x3'2.3-week_14-16-Mesenchymal_osteo-stroma-osteochondral_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	FN1 KCNK17 SULF1 ENPP2	2.88e-05	197	40	4	c165c6fd12dc649b39e920d8528e2eb65c61956b
ToppCell	Parenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_arterial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RXFP1 PRKX SULF1 ENPP2	2.94e-05	198	40	4	002424b24dacac553e02d0f764a6e8a1e567b9df
ToppCell	mLN-(5)_Dendritic_cell-(54)_pDC\|mLN / shred on region, Cell_type, and subtype	CDH23 MAN1A1 KCNK17 ENPP2	3.00e-05	199	40	4	1e738219784a446ee8b0ddeb408e0050e1929e60
ToppCell	mLN-Dendritic_cell-pDC\|mLN / Region, Cell class and subclass	CDH23 MAN1A1 KCNK17 ENPP2	3.00e-05	199	40	4	54f1abb57af7bf8a8b82a38b933f257df3b5d8df
ToppCell	10x5'v1-week_14-16-Mesenchymal_osteo-stroma-osteochondral_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	FN1 KCNK17 SULF1 ENPP2	3.05e-05	200	40	4	ad3fb8ef0be45032369d1325024787fbe1dfb8d6
ToppCell	10x5'v1-week_14-16-Hematopoietic-HSC/MPP_and_pro-myeloid_DC_progenitor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	TRBV25-1 RXFP1 CHD5	1.92e-04	125	40	3	baccea6889a829e05a9feac71b420f483a8107b4
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Dendritic_cell-DC_plasmacytoid\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	KCNK17 BDH1 DNAH1	2.35e-04	134	40	3	0e3f37ef041b751ed45060b5ce39385a2731370b
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6b\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SCN10A RXFP1 SULF1	2.73e-04	141	40	3	5ef3166c5271aa90fd0633016edfe2c74b835319
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Col27a1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MAN1A1 TRB ENPP2	3.54e-04	154	40	3	d22902d2922784583f7016453768ed05b14b965e
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Fibroblasts-Pericyte_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CDH23 GRIN2C SULF1	3.82e-04	158	40	3	7f5426585d0d299d2b48e5fcb349950feffdef33
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MAN1A1 PRC1 CHD5	4.41e-04	166	40	3	bb8135119dc37fdbba476599a56d368f422688dc
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-plasma_cell-plasma_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CDH23 MRPL57 MAN1A1	4.49e-04	167	40	3	8ec7a98b542b134f48df8fbec351693cc5cfe55c
ToppCell	facs-Marrow-Granulocytes-18m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDH23 HNMT MTOR	4.49e-04	167	40	3	a82e85caf79395baa48380786d9df32a86dfd1ce
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-plasma_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CDH23 MRPL57 MAN1A1	4.49e-04	167	40	3	a9f28c4649ce344ae3ba3a3acb58da9c7efad901
ToppCell	facs-Marrow-Granulocytes-18m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDH23 HNMT MTOR	4.49e-04	167	40	3	528493896aebe7d03d4b6ad2341b12927859e2e4
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4-5_RORB_AIM2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIN2C MAN1A1 TRB	4.49e-04	167	40	3	4c8bb68ee2bf7b794940b34df96f38f3f69507e9
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDH23 MRPL57 MAN1A1	4.64e-04	169	40	3	e348d9877a1bcad4f33dd7b2ce6cb0049583c4d2
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-Plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDH23 MRPL57 MAN1A1	4.64e-04	169	40	3	3167ca0c826244280e0e07d1e02656cf5e4e75a5
ToppCell	normal_Lung-Fibroblasts-Pericytes\|Fibroblasts / Location, Cell class and cell subclass	SCNN1G KCNK17 PRKX	4.72e-04	170	40	3	d69c0ea4cb6b204f19d0a5d2164afb42184779ac
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN10A RXFP1 BDH1	4.72e-04	170	40	3	da4fb1e186e9bec6bba0b25f2a0e68f9e11c6017
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCN10A RXFP1 BDH1	4.72e-04	170	40	3	cb1ed6bd409ee1cf11be0d5e7cdcffe2ab220d38
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Chat_Htr1f\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RXFP1 NT5DC2 ENPP2	4.81e-04	171	40	3	f9ae7964a3740f559431125c17c660549798cccc
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4-5_RORB_ASCL1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SCN10A MAN1A1 TRB	4.97e-04	173	40	3	2e35bf2b5534a289d93a09faae660f665c131062
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RXFP1 SULF1 PRKY	4.97e-04	173	40	3	95c723b09254ae7131fe5ba0841472502e83269b
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RXFP1 SULF1 PRKY	5.06e-04	174	40	3	e4d65fe121a32ac4cdd6312e7b8f867f0852e991
ToppCell	15-Trachea-Mesenchymal-Mesenchyme_RSPO2+\|Trachea / Age, Tissue, Lineage and Cell class	PRC1 FN1 MTOR	5.06e-04	174	40	3	fa0681e91724b9a51ee28b214ea5aa14e62ba1a3
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_progenitors\|lymph-node_spleen / Manually curated celltypes from each tissue	PRC1 KCNK17 NT5DC2	5.06e-04	174	40	3	029394e107bf7ad58056d2216070aa2e964fff12
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L2-4_SST_AHR\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PRKX SULF1 TRB	5.23e-04	176	40	3	322259a35f5c97d73ce7f75835dcdb5c954c91f8
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RXFP1 SULF1 PRKY	5.23e-04	176	40	3	72a2a01618ce836bc843395d5095e9090759b4a6
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|390C / Donor, Lineage, Cell class and subclass (all cells)	FN1 KCNK17 SULF1	5.23e-04	176	40	3	852d3da0907fe87c0ef23d75a63ce07619cf0c54
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	FN1 KCNK17 SULF1	5.23e-04	176	40	3	d2df1e435996c51213e88270af9f928e9e09a6f5
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RXFP1 SULF1 PRKY	5.31e-04	177	40	3	4c069f0d044a96118090b85ca592a21d6b5d9399
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GRIN2C PRC1 FN1	5.40e-04	178	40	3	9fc5688cf705a74398d24e10e0aab4758612e72b
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FN1 CHD5 NAGA	5.40e-04	178	40	3	e5e5f5b4a27e120a1076b1cb250fa25d0c336956
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FN1 SULF1 ENPP2	5.40e-04	178	40	3	5f779a66aa42d1d8e8af17b4a08d5dcc733efd4c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FN1 CHD5 NAGA	5.40e-04	178	40	3	c661246269ce26c4fc62e12f86c5f90a2dcfdce0
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_3\|356C / Donor, Lineage, Cell class and subclass (all cells)	TRIM69 MTOR ENPP2	5.49e-04	179	40	3	f378307eb20f002450c748b7be2289d6db2fcbcb
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_CPZ\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RXFP1 TRIM64C SULF1	5.58e-04	180	40	3	a499548391e6833b78f6e920f8e32a755814a9da
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RXFP1 SULF1 PRKY	5.58e-04	180	40	3	b514c55e52b46e8a1a2f09ed2c59a7683367a505
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RXFP1 SULF1 PRKY	5.67e-04	181	40	3	08f44323bf71b6004a921bbc969c954c75feeb66
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-Plasma_cell-B_c05-MZB1-XBP1\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	SCNN1G MAN1A1 NT5DC2	5.95e-04	184	40	3	af6522586d012e91241f3e06c60f9d1881e95646
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHD4 PRKX RSF1	5.95e-04	184	40	3	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MAN1A1 HNMT ENPP2	6.04e-04	185	40	3	8207f9eff113eed429e961748c6b17d672a13b33
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c3-EREG\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	WDFY3 FN1 HNMT	6.04e-04	185	40	3	7bff05d8d34616adbaa0ea0b69eb30aa906bb9f8
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)-D175\|Adult / Lineage, Cell type, age group and donor	WDFY3 GRIN2C ENPP2	6.04e-04	185	40	3	ab5704b96f1d368911308797d10c7c52766ab134
ToppCell	3'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FN1 SULF1 ENPP2	6.04e-04	185	40	3	fa94c4a1660967f211ba095606cd0aa37d38e17a
ToppCell	343B-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|343B / Donor, Lineage, Cell class and subclass (all cells)	HNMT ENPP2 NAGA	6.04e-04	185	40	3	d4ba36bdb8b7e3a62e827269484f89f790eaa5ef
ToppCell	facs-Heart-LA-24m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RXFP1 GRIN2C BDH1	6.14e-04	186	40	3	337f768cc43db2db96ba6495b076006b1a5b0331
ToppCell	facs-Heart-LA-24m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RXFP1 GRIN2C BDH1	6.14e-04	186	40	3	e378c82ef6d6cb24751515aa499a01372b3e7ccf
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RXFP1 SULF1 ENPP2	6.14e-04	186	40	3	8ea708070166c858cd9bd871670655b0114c32a5
ToppCell	3'-Adult-Appendix-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FN1 SULF1 ENPP2	6.23e-04	187	40	3	ec98d5e480b08854dfd0ba6b1dc6610455f90640
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D175\|Adult / Lineage, Cell type, age group and donor	CDH23 FN1 ENPP2	6.23e-04	187	40	3	e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRC1 FN1 SULF1	6.23e-04	187	40	3	e41e39fd3791acf8ae5376cc5061e196d96868ae
ToppCell	3'_v3-blood-Myeloid_Dendritic-DC2\|blood / Manually curated celltypes from each tissue	KCNK17 NT5DC2 TIPARP	6.23e-04	187	40	3	9f3db9f0e5de34aeabfe5984f675bc7a65435df7
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRC1 FN1 SULF1	6.23e-04	187	40	3	cefa211ef224e803ea9467882e2ca74d0b1492f1
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Pleural_Mac\|metastatic_Lymph_Node / Location, Cell class and cell subclass	HNMT GPR142 ENPP2	6.23e-04	187	40	3	88fac9f23047892acccbcc355d02ff079596fedf
ToppCell	droplet-Marrow-BM-1m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IPO5 FN1 NAGA	6.23e-04	187	40	3	028e7d6e1211e123879d2f353dc32fae1185dd8e
ToppCell	3'-Adult-Appendix-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FN1 SULF1 ENPP2	6.23e-04	187	40	3	37d8ee5c8bd6324749e5a2adef1d0482c75da80c
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TRIM69 MTOR ENPP2	6.23e-04	187	40	3	c8278525b3e1d3f3f4defcaf109cce22dd2e157a
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FN1 KCNK17 ENPP2	6.23e-04	187	40	3	c104fbfef2d0bef64077ac721edf2379fd59d547
ToppCell	LAM-Lymphoid-pDC\|Lymphoid / Condition, Lineage and Cell class	CDH23 KCNK17 ENPP2	6.23e-04	187	40	3	4d9ffd2bbdf1c9869e28991ce9331e4ccf3c0166
ToppCell	Control-Endothelial_cells-Arterial_endothelial_cells\|Control / group, cell type (main and fine annotations)	RXFP1 SULF1 ENPP2	6.23e-04	187	40	3	81affaab3fe3e1daea45ada6445e906ddd33950e
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-Plasma_cell\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	SCNN1G MAN1A1 NT5DC2	6.33e-04	188	40	3	34873972dff9284dfcd26bb698c9d1df007f1cbb
ToppCell	10x5'-GI_large-bowel-Myeloid_Monocytic\|GI_large-bowel / Manually curated celltypes from each tissue	WDFY3 FN1 HNMT	6.33e-04	188	40	3	d0045fdda757d191dabc7853f6a6e99c0e97d93d
ToppCell	NS-critical-d_16-33-Myeloid-Monocyte-derived_DC\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FN1 HNMT ENPP2	6.33e-04	188	40	3	08eb1e4b719af53c52895557523d0a1b7421d849
ToppCell	3'_v3-Lung-Myeloid_Dendritic-Cycling_Dendritic\|Lung / Manually curated celltypes from each tissue	PRC1 KCNK17 ENPP2	6.33e-04	188	40	3	0e8ac42c439f30a05e015210e1d5c2dcb9d9d471
ToppCell	10x5'-GI_large-bowel-Myeloid_Monocytic-Classical_monocytes\|GI_large-bowel / Manually curated celltypes from each tissue	WDFY3 FN1 HNMT	6.33e-04	188	40	3	0bcf04aa47738f43c1a87dae5dc487738ee86f8c
ToppCell	Mesenchymal-myofibroblast_cell\|World / Lineage, Cell type, age group and donor	FN1 KCNK17 ENPP2	6.43e-04	189	40	3	44e37f88137bb249933eb615235b2cf2ae7f3925
ToppCell	facs-Thymus-Epithelium-3m-Mesenchymal\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 SULF1 ENPP2	6.43e-04	189	40	3	1db5dd1ef2a65251af2d5696622d1dd9c4ae2b55
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_3\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	TRIM69 MTOR ENPP2	6.43e-04	189	40	3	99b01893da9f9f7c9528afaffad178285211738b
ToppCell	facs-Thymus-Epithelium-3m-Mesenchymal-fibroblast\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 SULF1 ENPP2	6.43e-04	189	40	3	bfb1c183a8a2752a2368b74150e66181c6a9da48
ToppCell	facs-Thymus-Epithelium-3m-Mesenchymal-fibroblast\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 SULF1 ENPP2	6.43e-04	189	40	3	14833feea8f80744a06ece73f813eaeff8c4dd61
ToppCell	3'_v3-lymph-node_spleen-Myeloid_Mac\|lymph-node_spleen / Manually curated celltypes from each tissue	FN1 HNMT ENPP2	6.43e-04	189	40	3	aac79c41ce7acba722c45c016b2c6997fb772a96
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery\|Children_(3_yrs) / Lineage, Cell type, age group and donor	RXFP1 SULF1 ENPP2	6.53e-04	190	40	3	f6c38d197fd9d69a4f97cb2e72cd4747984c1a86
ToppCell	(2)_Fibroblasts-(21)_Fibro-2\|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis	MAN1A1 FN1 ENPP2	6.53e-04	190	40	3	d2afa08ad868acc6fce308ec21b0bf93591d4010
ToppCell	COVID-19-kidney-AQP1+SLC14A1+EC\|kidney / Disease (COVID-19 only), tissue and cell type	FN1 SULF1 ENPP2	6.53e-04	190	40	3	1519f34d31fe0817184c5865a0bc9f0cb479b1a4
ToppCell	10x3'2.3-week_14-16-Mesenchymal_myocytic\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	NMRK2 FN1 SULF1	6.63e-04	191	40	3	cc9a6a8fad17d6e1a08a68ab7512ae06b1249051
ToppCell	10x3'2.3-week_17-19-Myeloid_DC-DC-pDC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CDH23 KCNK17 ENPP2	6.63e-04	191	40	3	faf4de97003a938a243b0101456913c2b0e1804f
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-AEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	RXFP1 SULF1 ENPP2	6.63e-04	191	40	3	50601ef0a5a8f2c2120922989e08e85bf2d9b4ab
ToppCell	COVID-19_Moderate-pDC\|COVID-19_Moderate / disease group, cell group and cell class	CDH23 KCNK17 ENPP2	6.63e-04	191	40	3	9d0ffa65c547e20b4076fd97776d7738cbd453ec
ToppCell	10x3'2.3-week_14-16-Mesenchymal_myocytic-stroma\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	NMRK2 FN1 SULF1	6.63e-04	191	40	3	c16b920ee69ea8536e020ac3475abf1ce972c1e6
ToppCell	5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FN1 SULF1 ENPP2	6.63e-04	191	40	3	adb2e3efcad02889d8229325080da5e7830fd3ae
ToppCell	343B-Endothelial_cells-Endothelial-B_(Artery)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	FN1 SULF1 ENPP2	6.63e-04	191	40	3	1dfcff08e01e6a695953334342bcfde04ba005ad
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L2-4_SST_AHR\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PRKX SULF1 TRB	6.63e-04	191	40	3	782bc7946417549ffd39e5b596db659436fa01ba
ToppCell	343B-Endothelial_cells-Endothelial-B_(Artery)\|343B / Donor, Lineage, Cell class and subclass (all cells)	FN1 SULF1 ENPP2	6.63e-04	191	40	3	27a532a35d9e8822014f581fd56c4ca62e39f8fe
ToppCell	5'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDH23 SULF1 ENPP2	6.73e-04	192	40	3	eafead22bba48ac5ee568faa8946c444445c1034
ToppCell	facs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MAN1A1 FN1 SULF1	6.73e-04	192	40	3	30cefa0990ba1f379f350bfbf994a78db145075e
ToppCell	IPF-Endothelial-VE_Arterial\|Endothelial / Disease state, Lineage and Cell class	FN1 PRKX SULF1	6.73e-04	192	40	3	e911e286da26202853f9650ba3cdefe5a5c9b585
ToppCell	Control-Endothelial-VE_Arterial\|Endothelial / Disease state, Lineage and Cell class	PRKX SULF1 ENPP2	6.73e-04	192	40	3	7e89b9125e8b85f6be85eeccef5c8644647ab0e1
ToppCell	facs-Aorta-Heart-3m-Mesenchymal\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAN1A1 FN1 ENPP2	6.73e-04	192	40	3	0dc1f46e40346ed0b286e53b106a812441575100
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAN1A1 FN1 ENPP2	6.73e-04	192	40	3	beac6b3c191b11add8e39e8d04562b478ea8929e
Computational	Genes upregulated in subsets of cells of a given type within various tumors	FN1 SULF1 ENPP2	2.03e-04	50	25	3	GAVISH_3CA_METAPROGRAM_ENDOTHELIAL_NOTCH_SIGNALING
Drug	Thonzonium bromide [553-08-2]; Down 200; 6.8uM; PC3; HT_HG-U133A	RANBP6 MRPL57 WDFY3 HNMT PRKX	1.49e-05	194	37	5	4617_DN
Drug	Cyproheptadine hydrochloride [969-33-5]; Down 200; 12.4uM; MCF7; HT_HG-U133A	MRPL57 PRKDC WDFY3 SULF1 BDH1	1.60e-05	197	37	5	5340_DN
Drug	Gliclazide [21187-98-4]; Up 200; 12.4uM; MCF7; HT_HG-U133A	SCN10A IPO5 NMRK2 FN1 HNMT	1.64e-05	198	37	5	5514_UP
Drug	okadaic acid tetramethyl ether	FN1 MTOR	2.56e-05	5	37	2	CID000147507
Drug	benzocaine	SCN10A SCNN1G NAGA	2.95e-05	37	37	3	CID000002337
Drug	sulfur mustard	FN1 HNMT BDH1 TIPARP	5.79e-05	130	37	4	CID000010461
Drug	ZSTK474	PRKDC MTOR	9.18e-05	9	37	2	ctd:C510150
Drug	N-(6-(6-chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)benzo(d)thiazol-2-yl)acetamide	PRKDC MTOR	1.15e-04	10	37	2	ctd:C558744
Drug	tresyl chloride	FN1 SULF1	1.15e-04	10	37	2	CID000074242
Drug	lidocaine	SCN10A SCNN1G KCNK17 ENPP2	1.29e-04	160	37	4	CID000003676
Drug	Parthenolide [20554-84-1]; Down 200; 16.2uM; MCF7; HT_HG-U133A	MAN1A1 HNMT SULF1 NT5DC2	1.39e-04	163	37	4	2885_DN
Drug	Emetine dihydrochloride [316-42-7]; Down 200; 7.2uM; HL60; HT_HG-U133A	IPO5 PRKDC FN1 PRKX	1.46e-04	165	37	4	2145_DN
Drug	saxitoxin	SCN10A SCNN1G ENPP2	1.61e-04	65	37	3	CID000037165
Drug	AC1L1CQC	SCN10A SCNN1G ENPP2	1.61e-04	65	37	3	CID000002012
Drug	heptylamine	FN1 HNMT	1.68e-04	12	37	2	CID000008127
Drug	mexiletine	SCN10A SCNN1G ENPP2	1.68e-04	66	37	3	CID000004178
Drug	Lycorine hydrochloride [2188-68-3]; Down 200; 12.4uM; HL60; HT_HG-U133A	NMRK1 PRKX BDH1 NT5DC2	1.71e-04	172	37	4	2195_DN
Drug	Parthenolide [20554-84-1]; Down 200; 16.2uM; HL60; HG-U133A	WDFY3 FN1 NT5DC2 ENPP2	1.95e-04	178	37	4	1736_DN
Drug	AC1LCJM3	SCNN1G ENPP2	1.98e-04	13	37	2	CID000631640
Drug	NaMN	NMRK1 NMRK2 ENPP2	2.01e-04	70	37	3	CID000000941
Drug	ICI 182,780; Down 200; 1uM; MCF7; HT_HG-U133A	NMRK1 PRKX SULF1 TIPARP	2.04e-04	180	37	4	5202_DN
Drug	5224221; Down 200; 12uM; MCF7; HT_HG-U133A_EA	BAHD1 PRKX SULF1 NT5DC2	2.04e-04	180	37	4	956_DN
Drug	strychnine HCl	SCN10A SCNN1G GRIN2C FN1	2.08e-04	181	37	4	CID000005304
Drug	T2755	SCN10A SCNN1G GRIN2C	2.09e-04	71	37	3	CID000005514
Drug	NSC7524	SCN10A SCNN1G GRIN2C ENPP2	2.12e-04	182	37	4	CID000005657
Drug	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	SCNN1G PRKDC MAN1A1 MTOR SULF1 NT5DC2	2.29e-04	546	37	6	ctd:C532162
Drug	germania	CDH23 NAGA	2.31e-04	14	37	2	CID000014796
Drug	1, 3-diallylurea	SCN10A SCNN1G TIPARP	2.37e-04	74	37	3	CID000074537
Drug	diphenhydramine	SCN10A SCNN1G HNMT	2.46e-04	75	37	3	CID000003100
Drug	Thiostrepton [1393-48-2]; Down 200; 2.4uM; MCF7; HT_HG-U133A	IPO5 MAN1A1 PRKX SULF1	2.50e-04	190	37	4	4385_DN
Drug	D-cycloserine [68-41-7]; Down 200; 39.2uM; MCF7; HT_HG-U133A	IPO5 MRPL57 HNMT SULF1	2.66e-04	193	37	4	3562_DN
Drug	alternariol monomethyl ether	SCNN1G ENPP2 TIPARP	2.66e-04	77	37	3	CID005360741
Drug	AC1L1W4O	SCNN1G ENPP2	2.66e-04	15	37	2	CID000036625
Drug	Moroxidine hydrochloride [3160-91-6]; Down 200; 19.2uM; PC3; HT_HG-U133A	SCN10A PRKDC WDFY3 BAHD1	2.71e-04	194	37	4	6705_DN
Drug	Sulfacetamide sodic hydrate [6209-17-2]; Down 200; 15.8uM; HL60; HT_HG-U133A	WDFY3 MAN1A1 FN1 PRKX	2.76e-04	195	37	4	1859_DN
Drug	Ethotoin [86-35-1]; Down 200; 19.6uM; MCF7; HT_HG-U133A	MRPL57 MAN1A1 HNMT PRKX	2.76e-04	195	37	4	6052_DN
Drug	GSK-3 Inhibitor IX; Up 200; 0.5uM; MCF7; HT_HG-U133A	MRPL57 HNMT BAHD1 TIPARP	2.76e-04	195	37	4	7101_UP
Drug	GSK-3 Inhibitor IX; Up 200; 0.5uM; PC3; HT_HG-U133A	SCN10A IPO5 MRPL57 CHD4	2.82e-04	196	37	4	6559_UP
Drug	Fluvastatin sodium salt [93957-55-2]; Down 200; 9.2uM; MCF7; HT_HG-U133A	BAHD1 SULF1 NAGA RSF1	2.82e-04	196	37	4	5290_DN
Drug	Naltrexone hydrochloride dihydrate [16676-29-2]; Down 200; 9.6uM; PC3; HT_HG-U133A	WDFY3 FN1 MTOR BDH1	2.82e-04	196	37	4	5765_DN
Drug	Ursolic acid [77-52-1]; Down 200; 8.8uM; PC3; HT_HG-U133A	IPO5 HNMT BAHD1 BDH1	2.87e-04	197	37	4	2067_DN
Drug	Sulfadiazine [68-35-9]; Down 200; 16uM; PC3; HT_HG-U133A	NMRK1 WDFY3 HNMT NAGA	2.87e-04	197	37	4	5098_DN
Drug	Azaperone [1649-18-9]; Down 200; 12.2uM; MCF7; HT_HG-U133A	MAN1A1 HNMT MTOR PRKX	2.87e-04	197	37	4	7231_DN
Drug	Zoxazolamine [61-80-3]; Down 200; 23.8uM; PC3; HT_HG-U133A	IPO5 NMRK1 WDFY3 NAGA	2.93e-04	198	37	4	6290_DN
Drug	Bupropion hydrochloride [31677-93-7]; Down 200; 14.4uM; HL60; HG-U133A	MAN1A1 FN1 ENPP2 RSF1	2.93e-04	198	37	4	1564_DN
Drug	Doxepin hydrochloride [1229-29-4]; Down 200; 12.6uM; MCF7; HT_HG-U133A	CHD4 FN1 BAHD1 SULF1	2.93e-04	198	37	4	7415_DN
Drug	Tolbutamide [64-77-7]; Up 200; 14.8uM; HL60; HT_HG-U133A	SCN10A WDFY3 FN1 ENPP2	2.98e-04	199	37	4	2359_UP
Drug	Ranitidine hydrochloride [66357-59-3]; Down 200; 11.4uM; PC3; HT_HG-U133A	MRPL57 WDFY3 HNMT MTOR	2.98e-04	199	37	4	6324_DN
Drug	Bromperidol [10457-90-6]; Down 200; 9.6uM; MCF7; HT_HG-U133A	IPO5 MRPL57 HNMT SULF1	2.98e-04	199	37	4	2872_DN
Drug	Norcyclobenzaprine [303-50-4]; Down 200; 15.4uM; MCF7; HT_HG-U133A	WDFY3 HNMT PRKX SULF1	2.98e-04	199	37	4	2830_DN
Drug	argiopine	GRIN2C ENPP2	3.04e-04	16	37	2	CID000122294
Drug	Lynestrenol [52-76-6]; Down 200; 14uM; MCF7; HT_HG-U133A	BAHD1 PRKX SULF1 RSF1	3.04e-04	200	37	4	5355_DN
Disease	ovarian neoplasm	PRC1 MTOR SULF1 TIPARP	2.39e-05	134	37	4	C0919267
Disease	Malignant neoplasm of ovary	PRC1 MTOR SULF1 TIPARP	2.61e-05	137	37	4	C1140680
Disease	sciatic neuropathy (implicated_via_orthology)	SCN10A MTOR	3.81e-04	23	37	2	DOID:11446 (implicated_via_orthology)
Disease	Left Ventricular Hypertrophy	FN1 MTOR	4.51e-04	25	37	2	C0149721
Disease	urate measurement, bone density	PRKDC GRIN2C SULF1 TIPARP DNAH1	1.00e-03	619	37	5	EFO_0003923, EFO_0004531
Disease	epilepsy (implicated_via_orthology)	SCN10A GRIN2C KCNK17	1.12e-03	163	37	3	DOID:1826 (implicated_via_orthology)
Disease	Thyroid carcinoma	MTOR ENPP2	1.40e-03	44	37	2	C0549473
Disease	ureteral obstruction (biomarker_via_orthology)	FN1 MTOR	1.46e-03	45	37	2	DOID:5199 (biomarker_via_orthology)
Disease	Hypertensive disease	SCNN1G FN1 MTOR	1.74e-03	190	37	3	C0020538
Disease	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	MTOR TRB	2.03e-03	53	37	2	C1961099
Disease	Metastatic melanoma	PRKDC MTOR	2.10e-03	54	37	2	C0278883

Protein segments in the cluster

Peptide	Gene	Start	Entry
RFYRYGIKPEWMMIH	CHD5	581	Q8TDI0
HPMDYYWWLRMQIMT	BDH1	316	Q02338
MLFVLMNWYYRTVHK	CDH23	3081	Q9H251
LKEVRFMMWNNHYIL	TIPARP	376	Q7Z3E1
WDFIHMIQMLYYVKD	HNMT	136	P50135
MNPSQRYPLWYKNMV	KCNK17	231	Q96T54
EHIMQMLQNPDWKYR	IPO5	361	O00410
QWVMAKYPVLYEESM	DNAH1	4006	Q9P2D7
VMYRIGDQWDKQHDM	FN1	476	P02751
LMMSLLWYYRPEHLQ	BAHD1	661	Q8TBE0
VMLYHMYVAPVHRDW	GPR142	376	Q7Z601
TYMYMWRLTHDPKYR	MAN1A1	551	P33908
RFYRYGIKPEWMMIH	CHD4	611	Q14839
LMYWYQLDQDHNVRM	RSF1	161	Q96T23
IQEWYKLHYMNIMAQ	SCNN1G	226	P51170
NMVPMYPAFKRVWNY	ENPP2	701	Q13822
TVHPQVTYAYMKNMW	MTOR	1691	P42345
HVWPMYLKYRQEMQD	NMRK1	146	Q9NWW6
DGHVWPMYQKYRQEM	NMRK2	146	Q9NPI5
IEAENHYWLSMPYMT	MRPL57	41	Q9BQC6
HYWLSMPYMTREQER	MRPL57	46	Q9BQC6
WHEERFLYMLMEYVP	PRKY	116	O43930
QKFMEYVAEQWEMHR	PRC1	426	O43663
VLIQANAWLHMPMYF	OR5M8	46	Q8NGP6
IMQMLQSPDWKYRHA	RANBP6	371	O60518
LLAYHIWRYMSRPVM	CNIH1	81	O95406
QYKGPIQYMVWREMQ	TRIM69	301	Q86WT6
RYLYHNVPDLASMWM	WDFY3	1876	Q8IZQ1
EVNMQPKWEDNVYMY	SCN10A	1381	Q9Y5Y9
MIHRFWYNYRQRKSM	RXFP1	691	Q9HBX9
LMYQWIEQDMEKYIL	NT5DC2	231	Q9H857
MNHEYMSWYRQDPGL	TRBV27	46	A0A0K0K1C4
WHDERFLYMLMEYVP	PRKX	116	P51817
MYWYQQDPGMELHLI	TRB	51	P0DTU4
EQMYNILMWIHDNYR	PRKDC	2471	P78527
MYWYQQDPGMELHLI	TRBV25-1	51	A0A075B6N4
MKDMYRELWETYHMP	TRIM64C	226	A6NLI5
YAPNMDKHWIMQYTG	SULF1	251	Q8IWU6
MRHNAMYWYRQDLGL	TRBV6-4	46	A0A1B0GX49
IINPWVYLERMGMYK	LEG1	51	Q6P5S2
VMWYLYPIKNLEMSQ	NAGA	396	P17050
MVGRWEHGVLYMKYP	GRIN2C	371	Q14957