Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sodium ion binding	SCN1A SCN2A SCN8A	2.67e-06	14	40	3	GO:0031402
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN1A SCN2A SCN8A	1.88e-05	26	40	3	GO:0005248
GeneOntologyMolecularFunction	alkali metal ion binding	SCN1A SCN2A SCN8A	1.88e-05	26	40	3	GO:0031420
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC6A3 OCA2 PKD1L3 RHBG ABCA13 SCN1A SCN2A SLC22A2 ABCB4 SCN8A	8.31e-05	1180	40	10	GO:0022857
GeneOntologyMolecularFunction	sodium channel activity	SCN1A SCN2A SCN8A	1.54e-04	52	40	3	GO:0005272
GeneOntologyMolecularFunction	transporter activity	SLC6A3 OCA2 PKD1L3 RHBG ABCA13 SCN1A SCN2A SLC22A2 ABCB4 SCN8A	1.73e-04	1289	40	10	GO:0005215
GeneOntologyMolecularFunction	monoamine transmembrane transporter activity	SLC6A3 SLC22A2	2.55e-04	12	40	2	GO:0008504
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC6A3 SCN1A SCN2A SCN8A	3.73e-04	171	40	4	GO:0015081
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	SCN1A SCN2A	5.22e-04	17	40	2	GO:0099508
GeneOntologyMolecularFunction	channel activity	OCA2 PKD1L3 RHBG SCN1A SCN2A SCN8A	5.76e-04	525	40	6	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	OCA2 PKD1L3 RHBG SCN1A SCN2A SCN8A	5.82e-04	526	40	6	GO:0022803
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC6A3 OCA2 PKD1L3 RHBG SCN1A SCN2A SCN8A	6.90e-04	758	40	7	GO:0015318
GeneOntologyMolecularFunction	neurotransmitter transmembrane transporter activity	SLC6A3 SLC22A2	8.02e-04	21	40	2	GO:0005326
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	SLC6A3 PKD1L3 RHBG SCN1A SCN2A SCN8A	1.45e-03	627	40	6	GO:0022890
GeneOntologyMolecularFunction	monoatomic ion channel activity	OCA2 PKD1L3 SCN1A SCN2A SCN8A	2.13e-03	459	40	5	GO:0005216
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC6A3 PKD1L3 SCN1A SCN2A SCN8A	2.25e-03	465	40	5	GO:0046873
GeneOntologyMolecularFunction	ABC-type transporter activity	ABCA13 ABCB4	4.34e-03	49	40	2	GO:0140359
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC6A3 OCA2 PKD1L3 SCN1A SCN2A SCN8A	4.66e-03	793	40	6	GO:0015075
GeneOntologyMolecularFunction	monoatomic cation channel activity	PKD1L3 SCN1A SCN2A SCN8A	4.80e-03	343	40	4	GO:0005261
GeneOntologyBiologicalProcess	membrane depolarization during action potential	SCN1A SCN2A SCN8A	4.97e-05	36	41	3	GO:0086010
GeneOntologyBiologicalProcess	actin-mediated cell contraction	DBN1 SCN1A SCN2A SCN8A	1.16e-04	127	41	4	GO:0070252
GeneOntologyBiologicalProcess	norepinephrine uptake	SLC6A3 SLC22A2	1.38e-04	9	41	2	GO:0051620
GeneOntologyBiologicalProcess	actin filament-based movement	DBN1 SCN1A SCN2A SCN8A	2.38e-04	153	41	4	GO:0030048
GeneOntologyBiologicalProcess	locomotory behavior	SLC6A3 ASTN1 DBN1 SCN1A SCN8A	2.39e-04	284	41	5	GO:0007626
GeneOntologyBiologicalProcess	cardiac muscle cell action potential involved in contraction	SCN1A SCN2A SCN8A	2.54e-04	62	41	3	GO:0086002
GeneOntologyBiologicalProcess	neuronal action potential	SCN1A SCN2A SCN8A	2.66e-04	63	41	3	GO:0019228
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN1A SCN2A SCN8A	4.67e-06	17	41	3	GO:0001518
GeneOntologyCellularComponent	node of Ranvier	SCN1A SCN2A SCN8A	7.80e-06	20	41	3	GO:0033268
GeneOntologyCellularComponent	presynaptic membrane	SLC6A3 AFDN SCN1A SCN2A SLC22A2 SCN8A	1.56e-05	277	41	6	GO:0042734
GeneOntologyCellularComponent	axon initial segment	SCN1A SCN2A SCN8A	2.47e-05	29	41	3	GO:0043194
GeneOntologyCellularComponent	sodium channel complex	SCN1A SCN2A SCN8A	2.47e-05	29	41	3	GO:0034706
GeneOntologyCellularComponent	synaptic membrane	SLC6A3 AFDN DBN1 SCN1A SCN2A SLC22A2 SCN8A	1.25e-04	583	41	7	GO:0097060
GeneOntologyCellularComponent	main axon	SCN1A SCN2A SCN8A	7.07e-04	89	41	3	GO:0044304
GeneOntologyCellularComponent	cell-cell contact zone	AFDN SCN1A SCN2A	8.29e-04	94	41	3	GO:0044291
GeneOntologyCellularComponent	cation channel complex	PKD1L3 SCN1A SCN2A SCN8A	1.14e-03	235	41	4	GO:0034703
GeneOntologyCellularComponent	excitatory synapse	AFDN DBN1 SCN8A	1.21e-03	107	41	3	GO:0060076
GeneOntologyCellularComponent	presynapse	SLC6A3 AFDN SGTA SCN1A SCN2A SLC22A2 SCN8A	1.53e-03	886	41	7	GO:0098793
GeneOntologyCellularComponent	axonemal A tubule inner sheath	EFHC1 EFCAB6	1.79e-03	32	41	2	GO:0160111
GeneOntologyCellularComponent	axonemal microtubule doublet inner sheath	EFHC1 EFCAB6	3.68e-03	46	41	2	GO:0160110
GeneOntologyCellularComponent	A axonemal microtubule	EFHC1 EFCAB6	3.84e-03	47	41	2	GO:0097649
GeneOntologyCellularComponent	axonemal doublet microtubule	EFHC1 EFCAB6	4.16e-03	49	41	2	GO:0097545
HumanPheno	Focal automatism seizure	SCN1A SCN2A SCN8A	2.82e-06	12	13	3	HP:0032898
HumanPheno	Photosensitive tonic-clonic seizure	EFHC1 SCN1A SCN2A	5.81e-06	15	13	3	HP:0007207
HumanPheno	Complex febrile seizure	SCN1A SCN2A SCN8A	7.14e-06	16	13	3	HP:0011172
HumanPheno	Visually-induced seizure	EFHC1 SCN1A SCN2A	1.04e-05	18	13	3	HP:0020216
HumanPheno	Myoclonus	POMGNT1 CTSF OCA2 EFHC1 SCN1A SCN2A SCN8A	1.20e-05	371	13	7	HP:0001336
HumanPheno	Reflex seizure	EFHC1 SCN1A SCN2A	1.95e-05	22	13	3	HP:0020207
HumanPheno	Focal hemiclonic seizure	SCN1A SCN2A SCN8A	2.89e-05	25	13	3	HP:0006813
HumanPheno	EEG with spike-wave complexes (>3.5 Hz)	EFHC1 SCN1A	3.60e-05	4	13	2	HP:0010849
HumanPheno	Simple febrile seizure	SCN1A SCN2A SCN8A	3.67e-05	27	13	3	HP:0011171
HumanPheno	Tremor	SLC6A3 PIGN CTSF OCA2 SCN1A SCN2A ABCB4 SCN8A	4.24e-05	639	13	8	HP:0001337
HumanPheno	EEG with spike-wave complexes	EFHC1 SCN1A SCN2A SCN8A	5.28e-05	88	13	4	HP:0010850
HumanPheno	Neonatal electro-clinical non-motor seizure	SCN2A SCN8A	5.99e-05	5	13	2	HP:0032812
HumanPheno	Neonatal seizure with electrographic correlate	SCN2A SCN8A	5.99e-05	5	13	2	HP:0032808
HumanPheno	Neonatal electro-clinical seizure	SCN2A SCN8A	5.99e-05	5	13	2	HP:0032809
HumanPheno	Neonatal electro-clinical seizure with behavior arrest	SCN2A SCN8A	5.99e-05	5	13	2	HP:0032823
HumanPheno	Focal head nodding automatism seizure	SCN2A SCN8A	5.99e-05	5	13	2	HP:0032906
HumanPheno	Cogwheel rigidity	SLC6A3 SCN1A SCN2A	6.17e-05	32	13	3	HP:0002396
HumanPheno	Obsessive-compulsive trait	OCA2 SCN1A SCN2A	6.78e-05	33	13	3	HP:0008770
HumanPheno	Generalized clonic seizure	SCN1A SCN2A SCN8A	7.43e-05	34	13	3	HP:0011169
HumanPheno	Abnormal circulating inhibin level	POR OCA2	8.97e-05	6	13	2	HP:0031099
HumanPheno	Decreased circulating inhibin B concentration	POR OCA2	8.97e-05	6	13	2	HP:0031100
HumanPheno	Normal interictal EEG	SCN2A SCN8A	8.97e-05	6	13	2	HP:0002372
HumanPheno	Abnormal circulating inhibin B concentration	POR OCA2	8.97e-05	6	13	2	HP:0430147
HumanPheno	Involuntary movements	SLC6A3 PIGN POMGNT1 CTSF OCA2 EFHC1 SCN1A SCN2A ABCB4 SCN8A	1.03e-04	1248	13	10	HP:0004305
HumanPheno	Hyperkinetic movements	SLC6A3 SCN1A SCN2A	1.22e-04	40	13	3	HP:0002487
HumanPheno	Focal non-motor seizure	SCN1A SCN2A SCN8A	1.22e-04	40	13	3	HP:0032679
HumanPheno	Eyelid myoclonia seizure	SCN2A SCN8A	1.25e-04	7	13	2	HP:0032678
HumanPheno	Focal clonic seizure	SCN1A SCN2A SCN8A	1.41e-04	42	13	3	HP:0002266
HumanPheno	Intellectual disability, severe	POMGNT1 OCA2 CAMK2G SCN1A SCN2A SCN8A	1.58e-04	371	13	6	HP:0010864
HumanPheno	Photosensitive myoclonic seizure	SCN1A SCN2A	1.67e-04	8	13	2	HP:0001327
HumanPheno	Cyanotic episode	SCN1A SCN2A	1.67e-04	8	13	2	HP:0200048
HumanPheno	Choreoathetosis	PIGN SCN1A SCN2A SCN8A	1.96e-04	123	13	4	HP:0001266
HumanPheno	Chorea	SLC6A3 PIGN SCN1A SCN2A SCN8A	2.45e-04	248	13	5	HP:0002072
HumanPheno	Bilateral tonic-clonic seizure with focal onset	SCN1A SCN2A SCN8A	2.67e-04	52	13	3	HP:0007334
HumanPheno	Bilateral tonic-clonic seizure with generalized onset	EFHC1 SCN1A SCN2A	2.67e-04	52	13	3	HP:0025190
HumanPheno	Sudden unexpected death in epilepsy	SCN1A SCN8A	2.67e-04	10	13	2	HP:0033258
HumanPheno	Neonatal seizure	SCN2A SCN8A	3.26e-04	11	13	2	HP:0032807
HumanPheno	Limited neck range of motion	SCN1A SCN2A	3.26e-04	11	13	2	HP:0000466
HumanPheno	Infection-related seizure	EFHC1 SCN1A SCN2A SCN8A	3.69e-04	145	13	4	HP:0032892
HumanPheno	Seizure precipitated by febrile infection	EFHC1 SCN1A SCN2A SCN8A	3.69e-04	145	13	4	HP:0032894
HumanPheno	Febrile seizure (within the age range of 3 months to 6 years)	EFHC1 SCN1A SCN2A SCN8A	3.69e-04	145	13	4	HP:0002373
HumanPheno	Epilepsia partialis continua	SCN1A SCN2A	3.91e-04	12	13	2	HP:0012847
HumanPheno	Generalized myoclonic seizure	EFHC1 SCN1A SCN2A SCN8A	3.99e-04	148	13	4	HP:0002123
HumanPheno	Generalized cerebral atrophy/hypoplasia	SCN1A SCN2A	4.62e-04	13	13	2	HP:0007058
HumanPheno	Generalized tonic seizure	SCN1A SCN2A SCN8A	4.95e-04	64	13	3	HP:0010818
HumanPheno	Compulsive behaviors	OCA2 SCN1A SCN2A SCN8A	5.12e-04	158	13	4	HP:0000722
HumanPheno	Multifocal epileptiform discharges	SCN1A SCN2A SCN8A	5.42e-04	66	13	3	HP:0010841
HumanPheno	Athetosis	PIGN SCN1A SCN2A SCN8A	6.18e-04	166	13	4	HP:0002305
HumanPheno	Aortopulmonary collateral arteries	SCN1A SCN2A	6.20e-04	15	13	2	HP:0031834
HumanPheno	Facial tics	SCN1A SCN2A	6.20e-04	15	13	2	HP:0011468
HumanPheno	Dysgenesis of the hippocampus	SCN1A SCN2A	7.07e-04	16	13	2	HP:0025101
HumanPheno	Generalized non-motor (absence) seizure	EFHC1 SCN1A SCN2A SCN8A	7.71e-04	176	13	4	HP:0002121
HumanPheno	Focal motor status epilepticus	SCN1A SCN2A	8.00e-04	17	13	2	HP:0032663
HumanPheno	Atypical absence status epilepticus	SCN1A SCN2A	8.00e-04	17	13	2	HP:0011151
HumanPheno	Focal emotional seizure with laughing	SCN1A SCN2A	8.00e-04	17	13	2	HP:0010821
HumanPheno	Broad foot	PIGN POR OCA2 CAMK2G	8.22e-04	179	13	4	HP:0001769
HumanPheno	Generalized non-convulsive status epilepticus without coma	SCN1A SCN2A	8.99e-04	18	13	2	HP:0032860
HumanPheno	Focal emotional seizure	SCN1A SCN2A	8.99e-04	18	13	2	HP:0025613
HumanPheno	Aggressive behavior	OCA2 EFHC1 CAMK2G SCN1A SCN2A SCN8A	9.66e-04	516	13	6	HP:0000718
HumanPheno	Abnormal aggressive, impulsive or violent behavior	OCA2 EFHC1 CAMK2G SCN1A SCN2A SCN8A	9.66e-04	516	13	6	HP:0006919
HumanPheno	Clonic seizure	SCN1A SCN2A SCN8A	9.88e-04	81	13	3	HP:0020221
HumanPheno	Abnormality of central nervous system electrophysiology	PIGN POMGNT1 OCA2 EFHC1 SCN1A SCN2A SCN8A	1.01e-03	738	13	7	HP:0030178
HumanPheno	Non-convulsive status epilepticus without coma	SCN1A SCN2A	1.11e-03	20	13	2	HP:0032671
HumanPheno	Psychomotor deterioration	SCN2A SCN8A	1.11e-03	20	13	2	HP:0002361
HumanPheno	Non-motor seizure	EFHC1 SCN1A SCN2A SCN8A	1.18e-03	197	13	4	HP:0033259
HumanPheno	Talipes valgus	SCN1A SCN2A	1.23e-03	21	13	2	HP:0004684
HumanPheno	EEG with abnormally slow frequencies	OCA2 SCN1A SCN8A	1.26e-03	88	13	3	HP:0011203
HumanPheno	EEG abnormality	POMGNT1 OCA2 EFHC1 SCN1A SCN2A SCN8A	1.33e-03	548	13	6	HP:0002353
HumanPheno	Focal sensory seizure	SCN1A SCN8A	1.35e-03	22	13	2	HP:0011157
HumanPheno	Status epilepticus	EFHC1 SCN1A SCN2A SCN8A	1.42e-03	207	13	4	HP:0002133
HumanPheno	Vertical nystagmus	PIGN SCN1A	1.48e-03	23	13	2	HP:0010544
HumanPheno	Focal tonic seizure	SCN2A SCN8A	1.48e-03	23	13	2	HP:0011167
HumanPheno	Tibial torsion	SCN1A SCN2A	1.48e-03	23	13	2	HP:0100694
HumanPheno	Rigidity	SLC6A3 SCN1A SCN2A SCN8A	1.61e-03	214	13	4	HP:0002063
HumanPheno	Intellectual disability, borderline	OCA2 SCN8A	1.75e-03	25	13	2	HP:0006889
HumanPheno	Epileptic aura	SCN1A SCN8A	1.75e-03	25	13	2	HP:0033348
HumanPheno	Generalized-onset motor seizure	EFHC1 SCN1A SCN2A SCN8A	2.03e-03	228	13	4	HP:0032677
HumanPheno	Limited knee extension	SCN1A SCN2A	2.04e-03	27	13	2	HP:0003066
HumanPheno	Status epilepticus without prominent motor symptoms	SCN1A SCN2A	2.04e-03	27	13	2	HP:0031475
HumanPheno	Bilateral tonic-clonic seizure	CTSF EFHC1 SCN1A SCN2A SCN8A	2.06e-03	394	13	5	HP:0002069
HumanPheno	Focal aware seizure	SCN1A SCN2A	2.19e-03	28	13	2	HP:0002349
HumanPheno	Abnormal tibia morphology	POR SCN1A SCN2A	2.21e-03	107	13	3	HP:0002992
HumanPheno	Intellectual disability, profound	POMGNT1 SCN1A SCN8A	2.33e-03	109	13	3	HP:0002187
HumanPheno	Status epilepticus with prominent motor symptoms	SCN1A SCN2A	2.35e-03	29	13	2	HP:0032658
HumanPheno	Limb myoclonus	SCN2A SCN8A	2.35e-03	29	13	2	HP:0045084
HumanPheno	Progressive gait ataxia	SCN1A SCN2A	2.51e-03	30	13	2	HP:0007240
HumanPheno	Progressive ataxia	SCN1A SCN2A	2.51e-03	30	13	2	HP:0001329
HumanPheno	Pallor	PIGN POMGNT1 OCA2 SCN1A SCN2A	2.66e-03	417	13	5	HP:0000980
HumanPheno	Abnormal lower limb bone morphology	PIGN POR POMGNT1 OCA2 CAMK2G SCN1A SCN2A	2.66e-03	866	13	7	HP:0040069
MousePheno	enhanced behavioral response to anesthetic	POR SCN8A	5.72e-05	5	34	2	MP:0009779
MousePheno	paraparesis	CTSF ARHGAP10 SCN8A	6.21e-05	32	34	3	MP:0009434
MousePheno	hindlimb paresis	CTSF ARHGAP10 SCN8A	9.65e-05	37	34	3	MP:0031204
Domain	Na_trans_cytopl	SCN1A SCN2A SCN8A	1.95e-07	6	41	3	PF11933
Domain	Na_trans_cytopl	SCN1A SCN2A SCN8A	1.95e-07	6	41	3	IPR024583
Domain	Na_channel_asu	SCN1A SCN2A SCN8A	1.17e-06	10	41	3	IPR001696
Domain	Na_trans_assoc	SCN1A SCN2A SCN8A	1.17e-06	10	41	3	IPR010526
Domain	Na_trans_assoc	SCN1A SCN2A SCN8A	1.17e-06	10	41	3	PF06512
Domain	Channel_four-helix_dom	SCN1A SCN2A SCN8A	2.65e-04	57	41	3	IPR027359
Domain	-	SCN1A SCN2A SCN8A	2.65e-04	57	41	3	1.20.120.350
Domain	IQ	SCN1A SCN2A SCN8A	7.44e-04	81	41	3	SM00015
Domain	IQ_motif_EF-hand-BS	SCN1A SCN2A SCN8A	1.01e-03	90	41	3	IPR000048
Domain	IQ	SCN1A SCN2A SCN8A	1.11e-03	93	41	3	PS50096
Domain	Ion_trans_dom	SCN1A SCN2A SCN8A	1.99e-03	114	41	3	IPR005821
Domain	Ion_trans	SCN1A SCN2A SCN8A	1.99e-03	114	41	3	PF00520
Domain	EF-hand-dom_pair	EFHC1 EFCAB6 SCN1A SCN8A	3.54e-03	287	41	4	IPR011992
Domain	AAA+_ATPase	DNAH2 ABCA13 ABCB4	3.86e-03	144	41	3	IPR003593
Domain	AAA	DNAH2 ABCA13 ABCB4	3.86e-03	144	41	3	SM00382
Domain	ABC_TRANSPORTER_2	ABCA13 ABCB4	4.98e-03	48	41	2	PS50893
Domain	ABC_tran	ABCA13 ABCB4	4.98e-03	48	41	2	PF00005
Domain	ABC_TRANSPORTER_1	ABCA13 ABCB4	5.18e-03	49	41	2	PS00211
Domain	ABC_transporter-like	ABCA13 ABCB4	5.39e-03	50	41	2	IPR003439
Pathway	REACTOME_PHASE_0_RAPID_DEPOLARISATION	CAMK2G SCN1A SCN2A SCN8A	8.54e-07	32	33	4	M27455
Pathway	WP_DRAVET_SYNDROME	SCN1A SCN2A SCN8A	3.68e-05	28	33	3	M45519
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SCN1A SCN2A SCN8A	5.02e-05	31	33	3	M877
Pathway	REACTOME_NEUROTRANSMITTER_CLEARANCE	SLC6A3 SLC22A2	1.47e-04	8	33	2	MM14500
Pathway	WP_RETT_SYNDROME	SCN1A SCN2A SCN8A	1.88e-04	48	33	3	M39759
Pathway	REACTOME_CARDIAC_CONDUCTION	CAMK2G SCN1A SCN2A SCN8A	2.30e-04	130	33	4	M27454
Pathway	REACTOME_NEUROTRANSMITTER_CLEARANCE	SLC6A3 SLC22A2	2.88e-04	11	33	2	M26914
Pathway	REACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS	SLC6A3 RHBG SLC22A2	7.31e-04	76	33	3	MM15072
Pathway	REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS	SLC6A3 SLC22A2	8.86e-04	19	33	2	MM15107
Pathway	REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS	SLC6A3 SLC22A2	8.86e-04	19	33	2	M27362
Pathway	REACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS	SLC6A3 RHBG SLC22A2	9.79e-04	84	33	3	M27334
Pathway	REACTOME_MUSCLE_CONTRACTION	CAMK2G SCN1A SCN2A SCN8A	1.23e-03	203	33	4	M5485
Pubmed	Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.	SCN1A SCN2A SCN8A	1.52e-09	3	41	3	17928448
Pubmed	Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.	SCN1A SCN2A SCN8A	1.52e-09	3	41	3	32845893
Pubmed	Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.	SCN1A SCN2A SCN8A	1.52e-09	3	41	3	28518218
Pubmed	Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.	SCN1A SCN2A SCN8A	6.08e-09	4	41	3	17537961
Pubmed	Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.	SCN1A SCN2A SCN8A	6.08e-09	4	41	3	35031483
Pubmed	Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.	SCN1A SCN2A SCN8A	6.08e-09	4	41	3	29578003
Pubmed	Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.	SCN1A SCN2A SCN8A	6.08e-09	4	41	3	21156207
Pubmed	A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.	SCN1A SCN2A SCN8A	3.03e-08	6	41	3	23652591
Pubmed	Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.	SCN1A SCN2A SCN8A	5.30e-08	7	41	3	25818041
Pubmed	Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.	SCN1A SCN2A SCN8A	1.27e-07	9	41	3	15746173
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN1A SCN2A SCN8A	1.27e-07	9	41	3	16382098
Pubmed	Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.	SCN1A SCN2A SCN8A	3.32e-07	12	41	3	30175250
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	SCN1A SCN2A SCN8A	4.31e-07	13	41	3	15123669
Pubmed	Association between SCN1A and SCN2A mutations and clinical/EEG features in Chinese patients from epilepsy or severe seizures.	SCN1A SCN2A	1.36e-06	2	41	2	29649454
Pubmed	Sodium channel expression within chronic multiple sclerosis plaques.	SCN2A SCN8A	1.36e-06	2	41	2	17805013
Pubmed	Missense mutations in sodium channel SCN1A and SCN2A predispose children to encephalopathy with severe febrile seizures.	SCN1A SCN2A	1.36e-06	2	41	2	26311622
Pubmed	Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy.	SCN1A SCN8A	1.36e-06	2	41	2	37901435
Pubmed	Aberrant regulation of a poison exon caused by a non-coding variant in a mouse model of Scn1a-associated epileptic encephalopathy.	SCN1A SCN8A	1.36e-06	2	41	2	33411788
Pubmed	An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior.	SCN1A SCN8A	1.36e-06	2	41	2	26410685
Pubmed	Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome.	SCN1A SCN8A	1.36e-06	2	41	2	31943325
Pubmed	Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.	SCN1A SCN2A	1.36e-06	2	41	2	10827969
Pubmed	Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A.	SCN1A SCN2A	1.36e-06	2	41	2	15249644
Pubmed	Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population.	SCN1A SCN2A	1.36e-06	2	41	2	19694741
Pubmed	Commonalities and distinctions between two neurodevelopmental disorder subtypes associated with SCN2A and SCN8A variants and literature review.	SCN2A SCN8A	1.36e-06	2	41	2	35348308
Pubmed	Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones.	SCN2A SCN8A	1.36e-06	2	41	2	15760941
Pubmed	The developmental changes of Na(v)1.1 and Na(v)1.2 expression in the human hippocampus and temporal lobe.	SCN1A SCN2A	1.36e-06	2	41	2	21377452
Pubmed	Differential expression of two sodium channel subtypes in human brain.	SCN1A SCN2A	1.36e-06	2	41	2	1317301
Pubmed	Reduced expression of Na(v)1.6 sodium channels and compensation by Na(v)1.2 channels in mice heterozygous for a null mutation in Scn8a.	SCN2A SCN8A	1.36e-06	2	41	2	18601978
Pubmed	Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children.	SCN1A SCN2A	1.36e-06	2	41	2	33096315
Pubmed	FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels.	SCN2A SCN8A	1.36e-06	2	41	2	19465131
Pubmed	Clinical exome sequencing identifies two novel mutations of the SCN1A and SCN2A genes in Moroccan patients with epilepsy: a case series.	SCN1A SCN2A	1.36e-06	2	41	2	31439038
Pubmed	Persistent Nav1.1 and Nav1.6 currents drive spinal locomotor functions through nonlinear dynamics.	SCN1A SCN8A	1.36e-06	2	41	2	37665666
Pubmed	The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy.	SCN1A SCN8A	1.36e-06	2	41	2	17881658
Pubmed	SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients.	SCN1A SCN2A	1.36e-06	2	41	2	30693367
Pubmed	Block of a subset of sodium channels exacerbates experimental autoimmune encephalomyelitis.	SCN2A SCN8A	1.36e-06	2	41	2	23735284
Pubmed	Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance.	SCN1A SCN8A	4.06e-06	3	41	2	24704313
Pubmed	Gene-to-gene interaction between sodium channel-related genes in determining the risk of antiepileptic drug resistance.	SCN1A SCN2A	4.06e-06	3	41	2	19270815
Pubmed	Nav1.2 is expressed in caudal ganglionic eminence-derived disinhibitory interneurons: Mutually exclusive distributions of Nav1.1 and Nav1.2.	SCN1A SCN2A	4.06e-06	3	41	2	28784306
Pubmed	Association of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy.	SCN1A SCN2A	4.06e-06	3	41	2	32185219
Pubmed	Sodium channels SCN1A, SCN2A and SCN3A in familial autism.	SCN1A SCN2A	4.06e-06	3	41	2	12610651
Pubmed	Clinical exome sequencing as the first-tier test for diagnosing developmental disorders covering both CNV and SNV: a Chinese cohort.	SCN1A SCN2A	4.06e-06	3	41	2	32005694
Pubmed	Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy.	SCN1A SCN2A	4.06e-06	3	41	2	25155934
Pubmed	The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels.	SCN1A SCN8A	4.06e-06	3	41	2	28117367
Pubmed	SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.	SCN1A SCN2A	4.06e-06	3	41	2	23859570
Pubmed	Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.	SCN1A SCN2A	4.06e-06	3	41	2	14973256
Pubmed	Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.	SCN1A SCN2A	4.06e-06	3	41	2	18784617
Pubmed	Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.	SCN1A SCN2A	4.06e-06	3	41	2	17544618
Pubmed	Experimental and computational evidence that Calpain-10 binds to the carboxy terminus of NaV1.2 and NaV1.6.	SCN2A SCN8A	4.06e-06	3	41	2	38514708
Pubmed	Human Nav1.6 Channels Generate Larger Resurgent Currents than Human Nav1.1 Channels, but the Navβ4 Peptide Does Not Protect Either Isoform from Use-Dependent Reduction.	SCN1A SCN8A	4.06e-06	3	41	2	26182346
Pubmed	Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea.	SCN2A SCN8A	4.06e-06	3	41	2	16033895
Pubmed	Role of sodium channel subtype in action potential generation by neocortical pyramidal neurons.	SCN2A SCN8A	4.06e-06	3	41	2	29991598
Pubmed	De novo SCN1A, SCN8A, and CLCN2 mutations in childhood absence epilepsy.	SCN1A SCN8A	4.06e-06	3	41	2	31054517
Pubmed	Hepatic cytochrome P450 deficiency in mouse models for intrahepatic cholestasis predispose to bile salt-induced cholestasis.	POR ABCB4	4.06e-06	3	41	2	25068656
Pubmed	The Effect of Ca2+, Lobe-Specificity, and CaMKII on CaM Binding to NaV1.1.	CAMK2G SCN1A	4.06e-06	3	41	2	30142967
Pubmed	Drebrin preserves endothelial integrity by stabilizing nectin at adherens junctions.	AFDN DBN1	4.06e-06	3	41	2	23750010
Pubmed	Targeted DNA Sequencing from Autism Spectrum Disorder Brains Implicates Multiple Genetic Mechanisms.	SCN1A SCN2A	8.12e-06	4	41	2	26637798
Pubmed	Models for discovery of targeted therapy in genetic epileptic encephalopathies.	SCN1A SCN8A	8.12e-06	4	41	2	28742937
Pubmed	Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.	SCN1A SCN2A	8.12e-06	4	41	2	35801810
Pubmed	Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.	SCN1A SCN2A	8.12e-06	4	41	2	8974318
Pubmed	Interaction between the transcriptional corepressor Sin3B and voltage-gated sodium channels modulates functional channel expression.	SCN2A SCN8A	1.35e-05	5	41	2	24077057
Pubmed	Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.	SCN1A SCN2A	1.35e-05	5	41	2	1679748
Pubmed	A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.	SCN1A SCN2A	1.35e-05	5	41	2	8812438
Pubmed	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.	SCN1A SCN2A	1.35e-05	5	41	2	24337656
Pubmed	Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.	SCN2A SCN8A	1.35e-05	5	41	2	17724025
Pubmed	Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone?	SCN2A SCN8A	2.03e-05	6	41	2	17513486
Pubmed	Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes.	SCN1A SCN8A	2.84e-05	7	41	2	15272007
Pubmed	IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity.	SLC6A3 SLC22A2	4.86e-05	9	41	2	16024787
Pubmed	Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals.	SCN1A SCN8A	4.86e-05	9	41	2	17884088
Pubmed	Common variants associated with general and MMR vaccine-related febrile seizures.	SCN1A SCN2A	6.07e-05	10	41	2	25344690
Pubmed	Genetic profile of patients with epilepsy on first-line antiepileptic drugs and potential directions for personalized treatment.	SCN1A SCN2A	6.07e-05	10	41	2	20602612
Pubmed	Two new cataract loci, Ccw and To3, and further mapping of the Npp and Opj cataracts in the mouse.	OCA2 MGRN1	7.41e-05	11	41	2	8812411
Pubmed	Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.	SCN1A SCN2A	8.88e-05	12	41	2	8169823
Pubmed	WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination.	SCN2A SCN8A	1.05e-04	13	41	2	16723544
Pubmed	Pigmentation-related genes and their implication in malignant melanoma susceptibility.	OCA2 MGRN1	1.22e-04	14	41	2	19320733
Pubmed	Confirmation of quantitative trait loci for alcohol preference in mice.	SCN1A SCN2A	1.41e-04	15	41	2	9726281
Pubmed	GABRA1 and STXBP1: novel genetic causes of Dravet syndrome.	NOL11 SCN1A	1.41e-04	15	41	2	24623842
Pubmed	Rapid and Integrative Discovery of Retina Regulatory Molecules.	DBN1 ABCA13	1.61e-04	16	41	2	30157441
Pubmed	Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice.	SCN2A SCN8A	2.05e-04	18	41	2	37321992
Pubmed	In silico QTL mapping of basal liver iron levels in inbred mouse strains.	SLC22A2 MAP3K4	2.81e-04	21	41	2	21062905
Pubmed	Candidate gene analysis in an on-going genome-wide association study of attention-deficit hyperactivity disorder: suggestive association signals in ADRA1A.	SLC6A3 SCN8A	5.03e-04	28	41	2	19352218
Pubmed	Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer's disease.	AFDN DBN1 SGTA CAMK2G	6.91e-04	341	41	4	29791485
Pubmed	De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking.	EFHC1 EFCAB6	7.87e-04	35	41	2	37865089
Pubmed	In-cell structural insight into the stability of sperm microtubule doublet.	EFHC1 EFCAB6	8.33e-04	36	41	2	37989994
Pubmed	Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain.	DBN1 CAMK2G	9.77e-04	39	41	2	22802532
Interaction	SCN4B interactions	SCN1A SCN2A SCN8A	4.35e-07	8	41	3	int:SCN4B
Interaction	SCN11A interactions	DBN1 SCN1A SCN8A	3.50e-06	15	41	3	int:SCN11A
Cytoband	2q24.3	SCN1A SCN2A	9.26e-05	16	41	2	2q24.3
Cytoband	16q22.2	PKD1L3 TXNL4B	1.78e-04	22	41	2	16q22.2
Cytoband	9p24.1	KDM4C PLPP6	4.29e-04	34	41	2	9p24.1
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN1A SCN2A SCN8A	4.20e-07	9	32	3	1203
Coexpression	GSE36392_EOSINOPHIL_VS_MAC_IL25_TREATED_LUNG_UP	SLC6A3 PLEKHH2 ARHGAP10 SLC22A2 ABCB4	1.47e-05	200	41	5	M5280
ToppCell	Control-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	DNAH2 EFHC1 EFCAB6 MORN2 ABCA13	9.12e-07	193	41	5	0e37d454f3735edd936ee9a5f5f516ac3aad400e
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	AFDN SLFN12L C1QTNF1 GLB1L3	1.79e-05	170	41	4	adb625124832b0786a590e8f75b61e7263a1e0d4
ToppCell	PND03-Immune-Immune_Myeloid-Megakaryocyte/Platelet\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC6A3 PKD1L3 ABCB4 NLRP6	1.87e-05	172	41	4	e39ea2f4edbf36ebf9604fa6f9349081859c596c
ToppCell	PND03-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC6A3 PKD1L3 ABCB4 NLRP6	1.87e-05	172	41	4	bcc50bed47465daa953ba91f17d1ee4c947ab461
ToppCell	PND03-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC6A3 PKD1L3 ABCB4 NLRP6	1.87e-05	172	41	4	875ea290840e835952623b905eb610f3c71456d2
ToppCell	3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH2 EFHC1 MORN2 ABCA13	1.91e-05	173	41	4	c3762655caa79ac4879876f470d32578a3c93b01
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH2 EFHC1 RHBG ABCA13	2.14e-05	178	41	4	3b12db04006db6e94fc45649a4b3a63b92f21a61
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A3 OCA2 PLEKHH2 ARHGAP10	2.28e-05	181	41	4	5f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A3 OCA2 PLEKHH2 ARHGAP10	2.28e-05	181	41	4	c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MELTF EFCAB6 ABCA13 SCN2A	2.44e-05	184	41	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MELTF EFCAB6 ABCA13 SCN2A	2.44e-05	184	41	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MELTF EFCAB6 ABCA13 SCN2A	2.44e-05	184	41	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EFHC1 MORN2 ABCA13 SLC22A2	2.71e-05	189	41	4	b4b93bd10b7e3cc16e54ff73beac230f519c010a
ToppCell	COPD-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	DNAH2 EFHC1 EFCAB6 ABCA13	2.71e-05	189	41	4	3e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	DNAH2 EFHC1 EFCAB6 MORN2	2.94e-05	193	41	4	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH2 EFHC1 EFCAB6 ABCA13	3.00e-05	194	41	4	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH2 EFHC1 MORN2 ABCA13	3.06e-05	195	41	4	649fd2336e963f6a150d182a53ad5dd838ca80b1
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH2 EFHC1 MORN2 ABCA13	3.06e-05	195	41	4	129ad5f4253ecb1a8477cc38773e6e91ea9570b0
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH2 EFHC1 MORN2 ABCA13	3.06e-05	195	41	4	3e70ee987d66d450062d5df3d7c733ccc7344470
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PLEKHH2 ARHGAP10 SCN1A SCN2A	3.06e-05	195	41	4	787e95fb59c40bba784544b662fac37606ae1427
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH2 EFHC1 MORN2 ABCA13	3.18e-05	197	41	4	87db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH2 EFHC1 MORN2 ABCA13	3.18e-05	197	41	4	91637bdeab85024b5a02d1066f76cb803a2d6420
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH2 EFHC1 MORN2 ABCA13	3.18e-05	197	41	4	22c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH2 EFHC1 MORN2 ABCA13	3.18e-05	197	41	4	3bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ASTN1 PLEKHH2 SCN1A SCN2A	3.31e-05	199	41	4	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	Macroglial-Polydendrocytes-PDGFRA---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	PLEKHH2 ARHGAP10 SCN1A SCN2A	3.37e-05	200	41	4	4fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCell	Macroglial-Polydendrocytes-PDGFRA-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	PLEKHH2 ARHGAP10 SCN1A SCN2A	3.37e-05	200	41	4	f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCell	Macroglial-Polydendrocytes-PDGFRA--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	PLEKHH2 ARHGAP10 SCN1A SCN2A	3.37e-05	200	41	4	cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCell	Macroglial-Polydendrocytes-PDGFRA----L1-6\|Macroglial / cells hierarchy compared to all cells using T-Statistic	PLEKHH2 ARHGAP10 SCN1A SCN2A	3.37e-05	200	41	4	310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCell	Macroglial-Polydendrocytes-PDGFRA\|Macroglial / cells hierarchy compared to all cells using T-Statistic	PLEKHH2 ARHGAP10 SCN1A SCN2A	3.37e-05	200	41	4	c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCell	Macroglial-Polydendrocytes\|Macroglial / cells hierarchy compared to all cells using T-Statistic	PLEKHH2 ARHGAP10 SCN1A SCN2A	3.37e-05	200	41	4	961858738ce35db8760c8c2e136f8369bc444ccf
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Nonmucinous_Lepidic_Adenocarcinoma-7\|TCGA-Lung / Sample_Type by Project: Shred V9	DNAH2 GLB1L3 MGRN1	2.32e-04	130	41	3	17a4ee699adfa265335b1abfe6cb0f3f7c93362b
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PLEKHH2 EFCAB6 ABCA13	2.59e-04	135	41	3	5113bb1713f99d01103b9a99de5d80393081cf87
ToppCell	PND07-28-samps-Mesenchymal-Mesenchymal_stem_cell\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	MCF2 TXNL4B SCN1A	2.71e-04	137	41	3	ed81624b9167255ce88dcf6ad7f1636376ea0525
ToppCell	PND07-28-samps-Mesenchymal-Mesenchymal_stem_cell-Mesenchymal_fibroblast\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	MCF2 TXNL4B SCN1A	2.71e-04	137	41	3	47859aa25f32367461c1ec75ed9060bee430c6b7
ToppCell	PBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-Neu_2\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	GLB1L3 ABCA13 PLPP6	3.07e-04	143	41	3	4622c221b5d2d4cd4f37e4f81662e073924e1507
ToppCell	PBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-Neu_2\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GLB1L3 ABCA13 PLPP6	3.07e-04	143	41	3	9836a040a2ebcf6f05431e658a7b8fd566621452
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A3 ABCA13 SCN1A	3.19e-04	145	41	3	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	COVID-19-kidney-Technical/muscle_(PCT)\|kidney / Disease (COVID-19 only), tissue and cell type	DNAH2 ABCA13 SCN1A	3.26e-04	146	41	3	c55f1bdb6ac43b4118cb27ea7c879527e1afcbab
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MCF2 SCN1A SCN2A	3.88e-04	155	41	3	77fdae85d36efb776db977eb424b32487ef222e4
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4/8-lo-Trm_Tgd\|lymph-node_spleen / Manually curated celltypes from each tissue	SLFN12L EFHC1 PLEKHH2	3.88e-04	155	41	3	b0e456c4915076e1d38282e116a6eb3230ae80dc
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c08-GZMK-FOS_h\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DBN1 RHBG TXNL4B	3.96e-04	156	41	3	14e2f693a75f1075f40cc7b16ee430262a5de016
ToppCell	3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLFN12L DBN1 PKD1L3	4.50e-04	163	41	3	e6213900f56257fe38ac7852351bea0340294be0
ToppCell	3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLFN12L DBN1 PKD1L3	4.50e-04	163	41	3	ed7319185c1ec384444309bb8be95691a0c2091c
ToppCell	3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLFN12L DBN1 PKD1L3	4.50e-04	163	41	3	ef35d7ff09aa364734fea7fdaab6260c0a3fbf09
ToppCell	facs-Lung-Endomucin-3m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHBG ABCA13 NLRP6	4.74e-04	166	41	3	a2ce44702a0cd5fa5872cac3302d3c451205feef
ToppCell	facs-Lung-Endomucin-3m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHBG ABCA13 NLRP6	4.74e-04	166	41	3	0f641302a6b71c4badaaf20f51162bfc2386b167
ToppCell	Children_(3_yrs)-Immune-enucleated_erythrocyte-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DBN1 ABCA13 PLPP6	4.91e-04	168	41	3	8f0c4dfad9f6fed9dcc31795abfe77758ceb46a1
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH2 EFHC1 ABCA13	5.00e-04	169	41	3	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Granulocytic\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A3 MELTF PLPP6	5.17e-04	171	41	3	b6502a81df4f25660f3ae4b7443a1d999df2d32b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Granulocytic-Mast_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A3 MELTF PLPP6	5.17e-04	171	41	3	ac37c80c832504986c7a201d84f4b6aff5e5f323
ToppCell	Ciliated_cells-B-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	EFHC1 MORN2 ABCA13	5.26e-04	172	41	3	187ae91148d293537afc77e10da2b64302322224
ToppCell	Int-URO-Lymphocyte-T_NK-dnT\|Int-URO / Disease, Lineage and Cell Type	PIGN CTSF EFHC1	5.26e-04	172	41	3	e70299573da1679d6d286c3a43699cbff76e207d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ASTN1 C1QTNF1 CAMK2G	5.53e-04	175	41	3	d52794426f2703a80e91ae0a8ff2d8e0ce4aa4a8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A3 PLEKHH2 ABCA13	5.53e-04	175	41	3	284fdc7a9d303636a637041846850d19d114861a
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ASTN1 C1QTNF1 CAMK2G	5.53e-04	175	41	3	454f03e6109d65f5db08dbb41ecc19ffb6bbc4e0
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PLEKHH2 ABCA13 ARHGAP10	5.62e-04	176	41	3	327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	OCA2 ABCA13 ARHGAP10	5.72e-04	177	41	3	da8802a6351d3e510822f82e2fde8a4314a2216e
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MELTF MORN2 ABCA13	5.91e-04	179	41	3	d15182c668d7c37be8214cad9f1fe35d1409c9a1
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MELTF MORN2 ABCA13	5.91e-04	179	41	3	e22a275a7c0ed19113c833a75d6c49fcc19aa13a
ToppCell	ASK454-Epithelial-Ciliated\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	EFHC1 MORN2 ABCA13	5.91e-04	179	41	3	f21919ef9d3d984e2925ef3d24f89e20fe265dcd
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH2 AFDN EFHC1	6.00e-04	180	41	3	92fb01b91261b3103454924cde56add337b41844
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EFHC1 MORN2 SLC22A2	6.00e-04	180	41	3	adf5db5bfa9a38b1227ab0beccd8d6f3eea67ac0
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EFHC1 MORN2 ABCA13	6.00e-04	180	41	3	1f1af4474f3f0ac3c0d6b1a6c875c354d36d8eec
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A3 PLEKHH2 ABCA13	6.10e-04	181	41	3	6a6bd8e020cb0929b6ecdcb55d467ad24fecfaf0
ToppCell	COVID-19-Heart-Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ASTN1 C1QTNF1 ARHGAP10	6.10e-04	181	41	3	33cac65ed1ea5e7bd72250495df4f850b143d5aa
ToppCell	Control-Epithelial_cells-Airway_ciliated\|Control / group, cell type (main and fine annotations)	DNAH2 EFCAB6 ABCA13	6.20e-04	182	41	3	fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A3 PLEKHH2 ABCA13	6.20e-04	182	41	3	5e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CTSF PLEKHH2 ARHGAP10	6.20e-04	182	41	3	3dfa9187e9d2bab1d199079d29209c4648220ada
ToppCell	RA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	OCA2 ARHGAP10 CAMK2G	6.30e-04	183	41	3	cae2ee08f985a6f005b4b8e959e465350315156a
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCN1A SCN2A SCN8A	6.40e-04	184	41	3	7d9bcdaff8cbea4c50ab7db0f8e01f6bbd0ef593
ToppCell	PBMC-Mild-cDC_9\|Mild / Compartment, Disease Groups and Clusters	PIGN C1QTNF1 SCN8A	6.40e-04	184	41	3	2e0c9a2c40c892a2d435eafb31f1f838de9baf15
ToppCell	COVID-19-Epithelial_cells-Airway_ciliated\|COVID-19 / group, cell type (main and fine annotations)	DNAH2 EFCAB6 ABCA13	6.50e-04	185	41	3	18a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A3 OCA2 PLEKHH2	6.50e-04	185	41	3	34fcfd635c828dad9643bbf1c908d79282d6f5d9
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Epcam____podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QTNF1 OCA2 PLEKHH2	6.50e-04	185	41	3	872720275789d249c9859de825a923803d458875
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A3 OCA2 PLEKHH2	6.50e-04	185	41	3	8816f2909ed11833ff3d0ed96b9cb6d6fe9e1578
ToppCell	Healthy-MAIT\|Healthy / disease group, cell group and cell class	SLFN12L C1QTNF1 DBN1	6.60e-04	186	41	3	028061f06d86e75cb06db56b199594b80f23fa58
ToppCell	Ciliated_cells-B-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	DNAH2 EFCAB6 ABCA13	6.60e-04	186	41	3	f72267d533fd0c5280d9741ceee3dd116300a7e4
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EFHC1 MORN2 RHBG	6.60e-04	186	41	3	903af26a63ec4b1755ab5cb81dfeb8dbd14bc5db
ToppCell	facs-Kidney-nan-24m-Epithelial-kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFCAB6 RHBG ABCA13	6.60e-04	186	41	3	7380af16e537cc49a2bb24ac50663d13c38459a7
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A3 PLEKHH2 ABCA13	6.60e-04	186	41	3	5c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCN1A SCN2A SCN8A	6.60e-04	186	41	3	7278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCell	facs-Kidney-nan-24m-Epithelial-kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFCAB6 RHBG ABCA13	6.60e-04	186	41	3	d56ccbe26bfddba0e2c54e7c7a5ca7f46fd3d891
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-Pericytes-Pericyte\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	C1QTNF1 PLEKHH2 ARHGAP10	6.60e-04	186	41	3	0c477016c1b539b3086a8066c3c6443f08c222a3
ToppCell	facs-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C1QTNF1 DBN1 HELQ	6.71e-04	187	41	3	fa8f221b4c2df61eadaa9c77e4cf45848b00330b
ToppCell	3'-Adult-LargeIntestine-Mesenchymal-stromal_related-T_reticular\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CTSF PLEKHH2 ARHGAP10	6.71e-04	187	41	3	f0c4d93f75615e570e4465fd622e3124189618a1
ToppCell	3'-Adult-LargeIntestine-Mesenchymal-stromal_related\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CTSF PLEKHH2 ARHGAP10	6.71e-04	187	41	3	3ff57da09ed8394913fb683669d7bff84a936623
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH2 EFHC1 MORN2	6.71e-04	187	41	3	e61992de4f98eeea08b43213850769d923f8db48
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCN1A SCN2A SCN8A	6.71e-04	187	41	3	7b2cd0c618ed081223343f3bec2244c8723c9a31
ToppCell	Adult-Epithelial-ciliated_cell-D231\|Adult / Lineage, Cell type, age group and donor	DNAH2 EFCAB6 ABCA13	6.81e-04	188	41	3	34b11f72ca73153d02edcd09b38983ad1a504659
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A3 OCA2 PLEKHH2	6.81e-04	188	41	3	874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A3 OCA2 PLEKHH2	6.81e-04	188	41	3	b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCell	Epithelial-ciliated_cell\|World / Lineage, Cell type, age group and donor	DNAH2 EFCAB6 ABCA13	6.81e-04	188	41	3	61a459f3fe57e5728efc72637ff2edc2d343492b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	C1QTNF1 ARHGAP10 CAMK2G	6.92e-04	189	41	3	2cfb4d12f75678d1619f4743838a0e954bd57761
ToppCell	343B-Epithelial_cells-Epithelial-F_(Ciliated)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DNAH2 EFHC1 MORN2	6.92e-04	189	41	3	57ab947b81dbd9d3e896be89e28c4a62cf720837
ToppCell	343B-Epithelial_cells-Epithelial-F_(Ciliated)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DNAH2 EFHC1 MORN2	6.92e-04	189	41	3	ebc16b8eab84167d74446783d7e802acedc6b9c6
ToppCell	Children_(3_yrs)-Epithelial-ciliated_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DNAH2 EFCAB6 ABCA13	6.92e-04	189	41	3	68a3cf7763d6f9b95d6d6524eff7a16042703f1d
ToppCell	facs-Thymus-Epithelium-3m-Mesenchymal\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QTNF1 CTSF DBN1	6.92e-04	189	41	3	1db5dd1ef2a65251af2d5696622d1dd9c4ae2b55
ToppCell	facs-Thymus-Epithelium-3m-Mesenchymal-fibroblast\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QTNF1 CTSF DBN1	6.92e-04	189	41	3	bfb1c183a8a2752a2368b74150e66181c6a9da48
ToppCell	facs-Thymus-Epithelium-3m-Mesenchymal-fibroblast\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QTNF1 CTSF DBN1	6.92e-04	189	41	3	14833feea8f80744a06ece73f813eaeff8c4dd61
Drug	Benztropine	SLC6A3 SLC22A2 ABCB4	2.17e-08	4	41	3	ctd:D001590
Drug	Procyclidine	SLC22A2 ABCB4	3.16e-06	2	41	2	ctd:D011352
Drug	Brompheniramine	SLC22A2 ABCB4	1.89e-05	4	41	2	ctd:D001977
Drug	APETx2 protein, Anthopleura elegantissima	SCN2A SCN8A	1.89e-05	4	41	2	ctd:C501880
Drug	Rescinnamin [24815-24-5]; Down 200; 6.4uM; MCF7; HT_HG-U133A	PIGN POR CAMK2G GPR107 MAP3K4	2.37e-05	192	41	5	2785_DN
Drug	Nomifensine	SLC6A3 ABCB4	3.15e-05	5	41	2	ctd:D009627
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN1A SCN2A SCN8A	2.97e-07	10	41	3	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN1A SCN2A SCN8A	2.97e-07	10	41	3	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN1A SCN2A SCN8A	5.43e-07	12	41	3	DOID:0060170 (implicated_via_orthology)
Disease	Benign familial infantile epilepsy	SCN2A SCN8A	5.65e-06	3	41	2	cv:C5575231
Disease	Epilepsy	ASTN1 SCN1A SCN2A SCN8A	1.61e-05	109	41	4	C0014544
Disease	glycoprotein measurement	PKD1L3 ARHGAP10 TXNL4B SLC22A2	2.27e-05	119	41	4	EFO_0004555
Disease	Familial benign neonatal epilepsy	SCN2A SCN8A	2.82e-05	6	41	2	C0220669
Disease	Seizure, Febrile, Simple	SCN1A SCN2A	3.94e-05	7	41	2	C0149886
Disease	Seizure, Febrile, Complex	SCN1A SCN2A	3.94e-05	7	41	2	C0751057
Disease	X-linked infantile spasms	CAMK2G SCN1A	5.25e-05	8	41	2	C4552072
Disease	Febrile Convulsions	SCN1A SCN2A	6.74e-05	9	41	2	C0009952
Disease	Generalized Epilepsy with Febrile Seizures Plus	SCN1A SCN2A	6.74e-05	9	41	2	C3502809
Disease	Infantile Severe Myoclonic Epilepsy	SCN1A SCN2A	1.46e-04	13	41	2	C0751122
Disease	adipic acid mesurement	MELTF KDM4C	1.46e-04	13	41	2	EFO_0010455
Disease	MMR-related febrile seizures	SCN1A SCN2A	1.96e-04	15	41	2	EFO_0006519
Disease	Epilepsy, Cryptogenic	SCN1A SCN2A SCN8A	2.04e-04	82	41	3	C0086237
Disease	Awakening Epilepsy	SCN1A SCN2A SCN8A	2.04e-04	82	41	3	C0751111
Disease	Aura	SCN1A SCN2A SCN8A	2.04e-04	82	41	3	C0236018
Disease	Early infantile epileptic encephalopathy with suppression bursts	SCN1A SCN2A	2.23e-04	16	41	2	C0393706
Disease	Febrile seizure (within the age range of 3 months to 6 years)	SCN1A SCN2A	2.84e-04	18	41	2	HP_0002373
Disease	Neurodevelopmental Disorders	SCN1A SCN2A SCN8A	2.96e-04	93	41	3	C1535926
Disease	haptoglobin measurement	PKD1L3 TXNL4B	3.89e-04	21	41	2	EFO_0004640
Disease	anxiety disorder (implicated_via_orthology)	SCN1A SCN2A	4.28e-04	22	41	2	DOID:2030 (implicated_via_orthology)
Disease	Bipolar Disorder	SLC6A3 DBN1 ABCA13 SCN2A SCN8A	5.01e-04	477	41	5	C0005586
Disease	lipoprotein A measurement	TXNL4B SLC22A2 MAP3K4	5.11e-04	112	41	3	EFO_0006925
Disease	apolipoprotein L1 measurement	PKD1L3 TXNL4B	5.54e-04	25	41	2	EFO_0021854
Disease	autism spectrum disorder (implicated_via_orthology)	SLC6A3 SCN1A SCN2A	1.24e-03	152	41	3	DOID:0060041 (implicated_via_orthology)
Disease	age at menarche	DNAH2 HELQ KDM4C SCN2A NLRP6	1.34e-03	594	41	5	EFO_0004703

Protein segments in the cluster

Peptide	Gene	Start	Entry
GVMRFYFQDKAAGNF	AFDN	41	P55196
FYFDTHQGLKFMQDL	ABCA13	2351	Q86UQ4
TLFGEMFFGYNNHSK	ASTN1	731	O14525
MFFGYNNHSKEVAAG	ASTN1	736	O14525
IAEQHGYGFSFMEFF	OCA2	796	Q04671
LNTFGFFKDGYMVVN	GPR107	56	Q5VW38
TEKHGNYFAYVQMFN	NOL11	171	Q9H8H0
LSFFQGMFTFYHQGH	ARHGAP10	201	A1A4S6
FGLGNKTYEHFNAMG	POR	171	P16435
KYEISFNVYMFHGGT	GLB1L3	331	Q8NCI6
NFGFMNGATYFGKHS	GLB1L3	346	Q8NCI6
KFGHVFYFVQASCMG	ARRDC5	126	A6NEK1
NYFASHFFMGGEKFD	MGRN1	31	O60291
KYFGSNIAHMYQVEF	KDM4C	956	Q9H3R0
GHFENQKVMYGFCSV	DBN1	56	Q16643
HFMNGIYQVVGFDAS	PLEKHH2	1126	Q8IVE3
KVGMFFQAVATFFAG	ABCB4	191	P21439
FVNLYDHFNMFTGKF	C1QTNF1	171	Q9BXJ1
EDYFNFMGHFTKPQQ	EFCAB6	926	Q5THR3
SVAINAFGMQFYRHG	CTSF	401	Q9UBX1
FGNMAEIYEFHNDIF	MCF2	546	P10911
MCSHGEGKINYYNFV	EFHC1	621	Q5JVL4
DDIYHFMNGTFFGVQ	HELQ	771	Q8TDG4
DFEFKGHFTSNVGYM	DNAH2	1166	Q9P225
HGGEFHFFQKQMFFL	SLC22A2	11	O15244
GNLVEGMDFHKFYFE	CAMK2G	466	Q13555
AGKLYQGQVDFAFFM	NLRP6	221	P59044
MIQGYNFGFEYHKEV	MAP3K4	1036	Q9Y6R4
NGFKMFDSSNYHGQD	MELTF	656	P08582
QMKVENFEAAVHFYG	SGTA	101	O43765
FGIVGLNMNGYFHEA	POMGNT1	501	Q8WZA1
KNENGFSYIMRGAFF	PKD1L3	1431	Q7Z443
FSIMGVNLFAGKFYH	SCN1A	1361	P35498
SGAVYEGQFKDNMFH	MORN2	11	Q502X0
FLDFMQNGNYFHIFV	SLFN12L	111	Q6IEE8
YPSFQDVHAMVFVGF	RHBG	61	Q9H310
GFVVFSFLGYMAQKH	SLC6A3	361	Q01959
FSIMGVNLFAGKFYH	SCN2A	1351	Q99250
FSIMGVNLFAGKYHY	SCN8A	1341	Q9UQD0
DGVKEIVSMFNHFYG	PIGN	236	O95427
IVSMFNHFYGNDGKT	PIGN	241	O95427
HMDFGQLYQFLNTKG	RWDD2B	291	P57060
HNVTDVAFGFFLGYM	PLPP6	256	Q8IY26
TVFFFNGQHMKVDYG	TXNL4B	81	Q9NX01