Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF10 ZNF410 IKZF3 IKZF2 ZNF154 ZNF670 ZNF658 MTF1 ZIC5 ZNF587 ZNF540 ZNF558 IKZF1 ZBTB41 ZNF619 LHX8 ZNF333 ZNF700 ZNF876P ZNF417 PRDM16 TAF1L ZNF681 ZNF669 ZNF551 ZNF77

1.28e-1014598426GO:0000977
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF10 IKZF3 ZNF154 ZNF670 ZNF658 MTF1 ZIC5 ZNF587 ZNF540 ZNF558 IKZF1 ZBTB41 ZNF619 LHX8 ZNF333 ZNF700 ZNF876P ZNF417 ZBTB42 PRDM16 ZNF681 ZNF669 ZNF551 ZNF77

2.08e-0914128424GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF410 IKZF3 IKZF2 ZNF154 ZNF670 ZNF658 MTF1 ZIC5 ZNF587 ZNF540 IKZF1 ZBTB41 ZNF333 ZNF876P ZNF417 PRDM16 ZNF681 ZNF551

3.29e-0612448418GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF410 IKZF3 IKZF2 ZNF154 ZNF670 ZNF658 MTF1 ZIC5 ZNF587 ZNF540 IKZF1 ZBTB41 ZNF333 ZNF876P ZNF417 PRDM16 ZNF681 ZNF551

4.45e-0612718418GO:0000987
DomainZnf_C2H2-like

ZNF10 ZNF410 ZC3H7A IKZF3 IKZF2 ZNF154 ZNF670 ZNF658 MTF1 ZIC5 ZNF587 ZNF540 ZNF558 ZFTA IKZF1 ZBTB41 ZNF619 ZNF333 ZNF700 ZNF417 ZBTB42 PRDM16 ZNF681 ZNF669 ZNF551 ZNF77

3.77e-167968326IPR015880
DomainZnF_C2H2

ZNF10 ZNF410 ZC3H7A IKZF3 IKZF2 ZNF154 ZNF670 ZNF658 MTF1 ZIC5 ZNF587 ZNF540 ZNF558 ZFTA IKZF1 ZBTB41 ZNF619 ZNF333 ZNF700 ZNF417 ZBTB42 PRDM16 ZNF681 ZNF669 ZNF551 ZNF77

5.40e-168088326SM00355
Domain-

ZNF10 ZNF410 IKZF3 IKZF2 ZNF154 ZNF670 ZNF658 MTF1 ZIC5 ZNF587 ZNF540 ZNF558 IKZF1 ZBTB41 ZNF619 ZNF333 ZNF700 ZNF417 ZBTB42 PRDM16 ZNF681 ZNF669 ZNF551 ZNF77

1.16e-1567983243.30.160.60
DomainZnf_C2H2/integrase_DNA-bd

ZNF10 ZNF410 IKZF3 IKZF2 ZNF154 ZNF670 ZNF658 MTF1 ZIC5 ZNF587 ZNF540 ZNF558 IKZF1 ZBTB41 ZNF619 ZNF333 ZNF700 ZNF417 ZBTB42 PRDM16 ZNF681 ZNF669 ZNF551 ZNF77

1.89e-156948324IPR013087
DomainZINC_FINGER_C2H2_2

ZNF10 ZNF410 ZC3H7A IKZF3 IKZF2 ZNF154 ZNF670 ZNF658 MTF1 ZIC5 ZNF587 ZNF540 ZNF558 IKZF1 ZBTB41 ZNF619 ZNF333 ZNF700 ZNF417 ZBTB42 PRDM16 ZNF681 ZNF669 ZNF551 ZNF77

2.13e-157758325PS50157
DomainZINC_FINGER_C2H2_1

ZNF10 ZNF410 ZC3H7A IKZF3 IKZF2 ZNF154 ZNF670 ZNF658 MTF1 ZIC5 ZNF587 ZNF540 ZNF558 IKZF1 ZBTB41 ZNF619 ZNF333 ZNF700 ZNF417 ZBTB42 PRDM16 ZNF681 ZNF669 ZNF551 ZNF77

2.26e-157778325PS00028
DomainZnf_C2H2

ZNF10 ZNF410 ZC3H7A IKZF3 IKZF2 ZNF154 ZNF670 ZNF658 MTF1 ZIC5 ZNF587 ZNF540 ZNF558 IKZF1 ZBTB41 ZNF619 ZNF333 ZNF700 ZNF417 ZBTB42 PRDM16 ZNF681 ZNF669 ZNF551 ZNF77

5.09e-158058325IPR007087
Domainzf-C2H2

ZNF10 ZNF410 IKZF3 IKZF2 ZNF154 ZNF670 ZNF658 MTF1 ZIC5 ZNF587 ZNF540 ZNF558 IKZF1 ZBTB41 ZNF619 ZNF333 ZNF700 ZNF417 PRDM16 ZNF681 ZNF669 ZNF551 ZNF77

1.97e-146938323PF00096
Domainzf-C2H2_6

ZNF10 ZNF154 ZNF670 ZNF658 ZNF587 ZNF540 ZNF558 ZBTB41 ZNF619 ZNF333 ZNF700 ZNF417 PRDM16 ZNF681 ZNF669 ZNF551 ZNF77

3.33e-143148317PF13912
DomainKRAB

ZNF10 ZNF154 ZNF670 ZNF658 ZNF587 ZNF540 ZNF558 ZNF333 ZNF700 ZNF417 ZNF681 ZNF669 ZNF551 ZNF77

5.61e-103588314PS50805
DomainKRAB

ZNF10 ZNF154 ZNF670 ZNF658 ZNF587 ZNF540 ZNF558 ZNF333 ZNF700 ZNF417 ZNF681 ZNF669 ZNF551 ZNF77

5.61e-103588314PF01352
DomainKRAB

ZNF10 ZNF154 ZNF670 ZNF658 ZNF587 ZNF540 ZNF558 ZNF333 ZNF700 ZNF417 ZNF681 ZNF669 ZNF551 ZNF77

8.32e-103698314SM00349
DomainKRAB

ZNF10 ZNF154 ZNF670 ZNF658 ZNF587 ZNF540 ZNF558 ZNF333 ZNF700 ZNF417 ZNF681 ZNF669 ZNF551 ZNF77

8.61e-103708314IPR001909
DomainCTCK_1

SLIT3 MUC2

2.85e-0318832PS01185
DomainCyclophilin-type_PPIase_CS

PPIL2 NKTR

3.18e-0319832IPR020892
DomainADH_SF_Zn-type

ADH6 ODR4

3.18e-0319832IPR002085
DomainCyclophilin-type_PPIase

PPIL2 NKTR

3.88e-0321832IPR024936
DomainCyclophilin-like_dom

PPIL2 NKTR

4.25e-0322832IPR029000
DomainCSA_PPIASE_2

PPIL2 NKTR

4.25e-0322832PS50072
DomainPro_isomerase

PPIL2 NKTR

4.25e-0322832PF00160
Domain-

PPIL2 NKTR

4.25e-03228322.40.100.10
DomainCT

SLIT3 MUC2

4.25e-0322832SM00041
DomainCyclophilin-type_PPIase_dom

PPIL2 NKTR

4.25e-0322832IPR002130
DomainCSA_PPIASE_1

PPIL2 NKTR

4.25e-0322832PS00170
Pubmed

Overexpression of novel short isoforms of Helios in a patient with T-cell acute lymphoblastic leukemia.

IKZF3 IKZF2 IKZF1

1.36e-08384311937265
Pubmed

Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors.

IKZF3 IKZF2 IKZF1

1.36e-0838439560339
Pubmed

Analysis of Ikaros family splicing variants in human hematopoietic lineages.

IKZF3 IKZF2 IKZF1

1.36e-08384320432734
Pubmed

Expression patterns of Ikaros family members during positive selection and lineage commitment of human thymocytes.

IKZF3 IKZF2 IKZF1

1.36e-08384327502439
Pubmed

Aberrant Ikaros, Aiolos, and Helios expression in Hodgkin and non-Hodgkin lymphoma.

IKZF3 IKZF2 IKZF1

1.36e-08384318332232
Pubmed

Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities.

IKZF3 IKZF2 IKZF1

1.35e-07584310978333
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF670 ZNF587 ZNF558 ZNF417 ZNF681 ZNF669 ZNF77

2.97e-0718184737372979
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

ZNF410 IKZF2 ZNF670 ZFP36L2 MTF1 ZIC5 ZBTB41 PLCG1 LHX8 PRDM16 ZNF681

3.95e-06808841120412781
Pubmed

A molecular dissection of the repression circuitry of Ikaros.

IKZF3 IKZF2 IKZF1

4.85e-061484312015313
Pubmed

Helios deficiency has minimal impact on T cell development and function.

IKZF2 IKZF1

5.76e-06284219620299
Pubmed

IKZF1/3 and CRL4CRBN E3 ubiquitin ligase mutations and resistance to immunomodulatory drugs in multiple myeloma.

IKZF3 IKZF1

5.76e-06284231558666
Pubmed

A variant in human AIOLOS impairs adaptive immunity by interfering with IKAROS.

IKZF3 IKZF1

5.76e-06284234155405
Pubmed

Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia.

IKZF3 IKZF1

5.76e-06284224509510
Pubmed

Role of Aiolos and Ikaros in the Antitumor and Immunomodulatory Activity of IMiDs in Multiple Myeloma: Better to Lose Than to Find Them.

IKZF3 IKZF1

5.76e-06284233499314
Pubmed

Genetic mapping and allelic loss analysis in mouse thymic lymphomas of Helios and Aiolos belonging to the Ikaros gene family.

IKZF3 IKZF2

5.76e-06284211173542
Pubmed

Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation.

IKZF3 IKZF1

5.76e-0628429155026
Pubmed

Suppression of Aiolos and Ikaros expression by lenalidomide reduces human ILC3-ILC1/NK cell transdifferentiation.

IKZF3 IKZF1

5.76e-06284231151137
Pubmed

Impaired tissue homing by the Ikzf3N159S variant is mediated by interfering with Ikaros function.

IKZF3 IKZF1

5.76e-06284237662955
Pubmed

Trans-Ancestral Fine-Mapping and Epigenetic Annotation as Tools to Delineate Functionally Relevant Risk Alleles at IKZF1 and IKZF3 in Systemic Lupus Erythematosus.

IKZF3 IKZF1

5.76e-06284233182226
Pubmed

Critical function of Ikaros in controlling Aiolos gene expression.

IKZF3 IKZF1

5.76e-06284217383641
Pubmed

High IKZF1/3 protein expression is a favorable prognostic factor for survival of relapsed/refractory multiple myeloma patients treated with lenalidomide.

IKZF3 IKZF1

5.76e-06284227881177
Pubmed

Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes.

IKZF2 IKZF1

5.76e-06284217681952
Pubmed

[Expression characteristics of isoforms of Ikaros and Helios in patients with leukemia and their mechanism].

IKZF2 IKZF1

5.76e-06284222931634
Pubmed

Ikaros promotes early-born neuronal fates in the cerebral cortex.

IKZF3 IKZF2 IKZF1

1.28e-051984323382203
Pubmed

Increased renal oxidative stress in salt-sensitive human GRK4γ486V transgenic mice.

GRK4 NOS3

1.73e-05384228189851
Pubmed

The genomic landscape of hypodiploid acute lymphoblastic leukemia.

IKZF3 IKZF2

1.73e-05384223334668
Pubmed

MACF1 links Rapsyn to microtubule- and actin-binding proteins to maintain neuromuscular synapses.

RAPSN MACF1

1.73e-05384230842214
Pubmed

The CD8alpha gene locus is regulated by the Ikaros family of proteins.

IKZF3 IKZF1

1.73e-05384212504015
Pubmed

Endothelial VEGFR2-PLCγ signaling regulates vascular permeability and antitumor immunity through eNOS/Src.

PLCG1 NOS3

1.73e-05384237651195
Pubmed

Differential expression of the immunosuppressive enzyme IL4I1 in human induced Aiolos+, but not natural Helios+, FOXP3+ Treg cells.

IKZF3 IKZF2

3.45e-05484225446972
Pubmed

Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.).

IKZF3 IKZF1

3.45e-05484224328678
Pubmed

The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins.

IKZF3 IKZF1

3.45e-05484224292623
Pubmed

Expression of adiponectin and its receptors in type 1 diabetes mellitus in human and mouse retinas.

NOS3 ADIPOR2

3.45e-05484223922494
Pubmed

RNA-Binding Protein ZFP36L2 Downregulates Helios Expression and Suppresses the Function of Regulatory T Cells.

IKZF2 ZFP36L2

3.45e-05484232655569
Pubmed

Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity.

IKZF3 IKZF1

5.74e-05584210766745
Pubmed

Interaction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interaction of GPR motifs with Gi alpha.

MACF1 GNAI3

8.59e-05684212719437
Pubmed

Phospholipase Cγ1 (PLCγ1) Controls Osteoclast Numbers via Colony-stimulating Factor 1 (CSF-1)-dependent Diacylglycerol/β-Catenin/CyclinD1 Pathway.

CSF1 PLCG1

8.59e-05684227941021
Pubmed

Ikaros and Aiolos inhibit pre-B-cell proliferation by directly suppressing c-Myc expression.

IKZF3 IKZF1

8.59e-05684220566697
Pubmed

Genome-wide survey and expression profiling of CCCH-zinc finger family reveals a functional module in macrophage activation.

ZC3H7A ZFP36L2

1.20e-04784218682727
Pubmed

Aiolos collaborates with Blimp-1 to regulate the survival of multiple myeloma cells.

IKZF3 IKZF1

1.20e-04784226823144
Pubmed

Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes.

IKZF3 IKZF1

1.20e-04784210357820
Pubmed

Helios transcription factor expression depends on Gsx2 and Dlx1&2 function in developing striatal matrix neurons.

IKZF2 IKZF1

2.05e-04984222142223
Pubmed

Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development.

IKZF3 IKZF1

2.05e-04984219734904
Pubmed

Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos.

IKZF2 IKZF1

2.05e-04984222638570
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

CEP170 ZFP36L2 DOCK11 RPS6KA2 MACF1 USP54 DPP8 PPIP5K2 SEC23B

2.35e-0486184936931259
Pubmed

Autoantibody of NRIP, a novel AChR-interacting protein, plays a detrimental role in myasthenia gravis.

RAPSN MACF1

2.56e-041084233773096
Pubmed

Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.

SLC47A1 NOS3 ADIPOR2

2.60e-045184320682687
Pubmed

Impact of genomic polymorphism on arterial hypertension after aortic coarctation repair.

GRK4 NOS3

3.13e-041184220537417
Pubmed

Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes.

IKZF3 IKZF1

3.13e-041184210204490
Pubmed

Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study.

GRK4 NOS3

3.13e-041184220577119
Pubmed

Slits and Robo-2 regulate the coalescence of subsets of olfactory sensory neuron axons within the ventral region of the olfactory bulb.

SLIT3 NCAM2

3.75e-041284222981605
Pubmed

Ikaros confers early temporal competence to mouse retinal progenitor cells.

IKZF2 IKZF1

4.42e-041384218940586
Pubmed

G proteins Gαi1/3 are critical targets for Bordetella pertussis toxin-induced vasoactive amine sensitization.

GNAI3 NOS3

5.93e-041584224478091
Pubmed

Possible roles of Robo1+ ensheathing cells in guiding dorsal-zone olfactory sensory neurons in mouse.

SLIT3 NCAM2

5.93e-041584223821580
Pubmed

Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.

PPIL2 NKTR

5.93e-041584220676357
Pubmed

Three human ARX mutations cause the lissencephaly-like and mental retardation with epilepsy-like pleiotropic phenotypes in mice.

LHX8 NOS3

5.93e-041584219605412
Pubmed

The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis.

TAF8 TAF1L

5.93e-041584214580349
Pubmed

Arx acts as a regional key selector gene in the ventral telencephalon mainly through its transcriptional repression activity.

ZIC5 LHX8

6.77e-041684219627984
Pubmed

RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation.

IKZF3 IKZF1

6.77e-041684230760870
Pubmed

Requirement for Slit-1 and Robo-2 in zonal segregation of olfactory sensory neuron axons in the main olfactory bulb.

SLIT3 NCAM2

6.77e-041684217715346
Pubmed

Ikaros SUMOylation: switching out of repression.

IKZF3 IKZF1

7.66e-041784215767674
Pubmed

Interferon regulatory factor 8 (IRF8) interacts with the B cell lymphoma 6 (BCL6) corepressor BCOR.

TAF8 CSF1

7.66e-041784225331958
Pubmed

Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria.

TAF8 TAF1L ADIPOR2

8.41e-047684322323595
Pubmed

The role of floor plate contact in the elaboration of contralateral commissural projections within the embryonic mouse spinal cord.

EPHB3 SLIT3

8.60e-041884216854408
Pubmed

Mesenchymal-epithelial interaction regulates gastrointestinal tract development in mouse embryos.

LHX8 MUC2

8.60e-041884235830795
Pubmed

Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.

EPHB3 IKZF3 LHX8

9.41e-047984318978678
Pubmed

Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation.

ZNF670 ZIC5

1.06e-032084212447396
Pubmed

Maternal exercise improves epithelial development of fetal intestine by enhancing apelin signaling and oxidative metabolism.

MUC2 PRDM16

1.06e-032084236189989
Pubmed

The LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouse.

IKZF2 IKZF1

1.06e-032084224082127
Pubmed

A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).

CSF1 SERPINC1 LTF NOS3

1.09e-0318684420673868
Pubmed

Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.

CSF1 SERPINC1 LTF NOS3

1.09e-0318684420452482
Pubmed

Long-range enhancers regulating Myc expression are required for normal facial morphogenesis.

CSF1 ASAP1

1.17e-032184224859337
Pubmed

Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease.

SLIT3 GNAI3

1.29e-032284218628988
Pubmed

AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene.

CSF1 IKZF1

1.29e-03228429811459
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

CEP170 ADAMTS9 MACF1 ZNF619 ZNF417 ASAP1

1.31e-0349784623414517
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

PARP11 ZC3H7A ZFP36L2 MTF1 ODR4 PPIL2 NIT1 NKTR PLCG1 FBXO21

1.35e-031327841032694731
Pubmed

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

IL31RA IKZF3 MLH3 RPS6KA2 IKZF1

1.46e-0334284523128233
Pubmed

Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues.

LHX8 PRDM16

1.54e-032484228324027
Pubmed

Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population.

CSF1 NOS3

1.67e-032584217355643
Pubmed

Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis.

ADAMTS9 PRDM16

1.67e-032584229475039
Pubmed

The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling.

LTF MUC2

1.67e-032584215809042
Pubmed

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.

CEP170 DOCK11 NCAM2 NKTR LTF PPIP5K2 ARHGAP20 ASAP1

1.68e-0391684832203420
Pubmed

Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub.

CACNB2 ADAM23 NCAM2 GNAI3

1.86e-0321584436808153
Pubmed

Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome.

MACF1 ASAP1

1.95e-032784218685082
Pubmed

Generation and analysis of 280,000 human expressed sequence tags.

CACNB2 ZFP36L2 GRK4 SERPINC1 CNN2

2.01e-033688458889549
Pubmed

Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

MACF1 ADAMTSL3 ASAP1

2.02e-0310384310574462
Pubmed

Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.

ODR4 PLCG1 ASAP1

2.02e-0310384321706016
Pubmed

Sohlh2 affects differentiation of KIT positive oocytes and spermatogonia.

MLH3 LHX8

2.09e-032884219014927
Pubmed

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

FBXO25 RAPSN RPS6KA2 GRK4 SPSB3

2.11e-0337284522939624
Pubmed

Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.

ADH6 DCAF15 ZNF670 USP54

2.23e-0322684431452512
Pubmed

Gene expression and characterization of clonally derived murine embryonic brown and brite adipocytes.

LHX8 PRDM16

2.24e-032984238972757
Pubmed

Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells.

IKZF3 IKZF1

2.40e-033084224292625
InteractionMID2 interactions

ZNF410 IKZF3 FAM161A ZNF587 USP54 ZNF417 ZBTB42 PRDM16 ZNF669

1.12e-06267809int:MID2
InteractionTSGA10 interactions

ZNF410 ZNF670 FAM161A ZNF587 ZNF417

4.21e-0597805int:TSGA10
InteractionBICD2 interactions

ZC3H7A ZNF670 FAM161A USP54 PPIP5K2 ZNF417 CNN2 ASAP1 ZNF669

4.77e-05426809int:BICD2
InteractionCCDC136 interactions

CEP170 ZNF670 FAM161A ZNF587 ZNF417 ZNF669

5.72e-05169806int:CCDC136
InteractionCCDC13 interactions

ZNF670 FAM161A USP54 PRDM16

5.81e-0553804int:CCDC13
Cytoband19q13.43

ZNF587 ZNF417 ZNF551

5.61e-048784319q13.43
Cytoband5q35

CLK4 SLIT3

8.16e-04238425q35
Cytoband1q44

CEP170 ZNF670 ZNF669

1.11e-031108431q44
CytobandEnsembl 112 genes in cytogenetic band chr19p13

DCAF15 ZNF558 ZNF333 ZNF700 CNN2 ZNF77

3.47e-03797846chr19p13
Cytoband12q24.33

ZNF10 P2RX2

3.53e-034884212q24.33
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF10 ZNF410 IKZF3 IKZF2 ZNF154 ZNF670 ZNF658 ZIC5 ZNF587 ZNF540 ZNF558 IKZF1 ZBTB41 ZNF619 ZNF333 ZNF700 ZNF417 ZBTB42 PRDM16 ZNF681 ZNF669 ZNF551 ZNF77

8.85e-17718632328
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

DOCK11 SLIT3 SORCS3 NCAM2 IL1RAP LRP1B

1.43e-061868468915436d09775f2828a7678af203b1082b36e21c
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-Macroglial|GW12 / Sample Type, Dataset, Time_group, and Cell type.

CSF1 IKZF1 PRDM16 NOS3 CNN2 ADIPOR2

2.18e-06200846be1abe5bb1ce4e7dfec63af4ed0fc5b96bf77866
ToppCell3'_v3-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

IKZF3 ZFP36L2 MACF1 NKTR PLCG1

9.93e-06151845999c11d19b61d6b130ad5e623afa83cbdfe13cdd
ToppCellCOVID-19_Moderate-multiplets|World / disease group, cell group and cell class

IKZF3 MACF1 NKTR PLCG1 ARHGAP20

1.16e-05156845afdc025fa75e7926b1cc182c4a33654a2186abb1
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-8|TCGA-Thryoid / Sample_Type by Project: Shred V9

IKZF2 ADAMTS9 SLIT3 ZFTA IL1RAP

1.66e-0516884500646601548b0fee42ae16bfa5e93603bc7c5129
ToppCellMesenchymal_cells-Osteo-CAR|Mesenchymal_cells / Lineage and Cell class

CSF1 ADAMTS9 P2RX2 SLIT3 CNN2

1.97e-05174845430e3cd61bc2a471959faa40e817aa4dd7d82d28
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IKZF2 ZNF587 MACF1 NKTR USP54

2.26e-051798456e965e424eebef50f0202cff75f458be395cfca1
ToppCellControl-Fibroblasts-Alveolar_FB|Control / group, cell type (main and fine annotations)

CACNB2 SLIT3 MACF1 NCAM2 ADAMTSL3

2.78e-0518784592d468dde81125d51daf7abd4703741abe1ab91c
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS9 DOCK11 RPS6KA2 SLC47A1 ARHGAP20

3.00e-0519084526843ec1d19ac85a50990705353b802745d33e4d
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CACNB2 SLIT3 MACF1 NCAM2 ADAMTSL3

3.08e-051918456688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CACNB2 SLIT3 MACF1 NCAM2 ADAMTSL3

3.16e-0519284599ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNB2 SLIT3 MACF1 NCAM2 ADAMTSL3

3.23e-05193845b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCellCOVID_non-vent-Lymphocytic-T_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

LPIN2 MACF1 IKZF1 NKTR PLCG1

3.40e-051958454bdedd924564a260841a9153604026b57487c83d
ToppCellnucseq-Mesenchymal-Fibroblastic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CACNB2 SLIT3 MACF1 NCAM2 ADAMTSL3

3.48e-051968457d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCellCOVID_non-vent-Lymphocytic|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

IKZF3 IKZF2 MACF1 NKTR PLCG1

3.57e-05197845c672915f8c8c1e948d251f6eaf9f84a5600c1193
ToppCellCOVID_non-vent-Lymphocytic-T_cell-CD8+_Memory_T_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

IKZF3 IKZF2 ZFP36L2 MACF1 NKTR

3.57e-05197845836061acd7f0d5de89b16f52ec679bdf09eac9db
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CACNB2 SLIT3 MACF1 ARHGAP20 LRP1B

3.57e-051978450034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW09-Neuronal-GABAergic_neurons|GW09 / Sample Type, Dataset, Time_group, and Cell type.

DCAF15 ZNF658 ZNF619 ZNF876P LRP1B

3.57e-0519784521f3ef7c3c10b4e3adde431097dfdcd513c74a95
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CACNB2 SLIT3 MACF1 ARHGAP20 LRP1B

3.57e-0519784511a4c417f035e554431a8f03be13b5eefa3530c0
ToppCellnucseq-Mesenchymal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CACNB2 SLIT3 MACF1 NCAM2 ADAMTSL3

3.65e-051988458f52243ca8b9ba68a75ae411506a3a6de258eb97
ToppCellBAL-Severe-Lymphocyte-T/NK-CD4+_T|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IKZF3 ZFP36L2 IKZF1 PLCG1 CNN2

3.74e-05199845b270d8274249103d3a1b4a4f8601c92fde007ed7
ToppCellBAL-Severe-Lymphocyte-T/NK|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IKZF3 ZFP36L2 IKZF1 PLCG1 CNN2

3.74e-0519984528cec7122b143373f1c7c94acf35bf8f896e0d57
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_memory_T_cell|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

IKZF3 IKZF2 ZFP36L2 IKZF1 PLCG1

3.74e-0519984569793ef363618030e4546877b3095c587617909f
ToppCellSevere_COVID-19-T/NK|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

IKZF3 ZFP36L2 IKZF1 PLCG1 CNN2

3.74e-05199845ace179b860513179e9275ed40ae1985a98385026
ToppCellBAL-Severe-Lymphocyte-T/NK|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

IKZF3 ZFP36L2 IKZF1 PLCG1 CNN2

3.74e-05199845c8a2c94809b2134b51bb9868b63cb280b490f3fe
ToppCellControl_saline-Mesenchymal_fibroblastic|Control_saline / Treatment groups by lineage, cell group, cell type

CACNB2 SLIT3 SORCS3 MACF1 ARHGAP20

3.83e-0520084564ae5cf6cb4fc94cf1052abd82648f6b8e6445fe
ToppCellmild-gd_T|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

IKZF3 IKZF2 ZFP36L2 MACF1 NKTR

3.83e-05200845109f673a4967ffa52270a0b4f818b3461288db44
ToppCellBronchial-NucSeq-Immune_Lymphocytic-T-T_CD4-CD4_naive/CM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

IKZF3 ZFP36L2 DOCK11 ADAM23 IKZF1

3.83e-05200845e0cec0a844b7c1f8edee4c005af27766754e470a
ToppCellLPS_only-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_only / Treatment groups by lineage, cell group, cell type

CACNB2 SLIT3 SORCS3 MACF1 ARHGAP20

3.83e-05200845a7ef7022b8efcaedb7319b0b43d8c4e99d788fe2
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts|Control_saline / Treatment groups by lineage, cell group, cell type

CACNB2 SLIT3 SORCS3 MACF1 ARHGAP20

3.83e-05200845a1fc74c1b27e104895910bc7cdce7ba33d30df7e
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|Control_saline / Treatment groups by lineage, cell group, cell type

CACNB2 SLIT3 SORCS3 MACF1 ARHGAP20

3.83e-05200845bd8cf33502adea320e91ca2af14e1911d88ad374
ToppCellLPS-IL1RA-Lymphocytic_NKT-iNKT/MAIT-T-cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IKZF3 IKZF2 ADAM23 IKZF1

1.39e-04139844ecc2a6ecc27748c50885cd4f0ad8a8cd1252aee6
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Ductal_and_Papillary_Carcinoma-1|TCGA-Breast / Sample_Type by Project: Shred V9

ODR4 ZBTB41 IL1RAP MUC2

1.47e-04141844330f944b38c3170dfc79ab033fae7b9ab71e840d
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c05-FOS|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RPS6KA2 FBXO21 SPSB3 ZNF77

1.72e-041478442d9044ddf01b6838a44a4518b442d7e7cb0bf910
ToppCellPND10-Immune-Immune_Myeloid-Granulocytic|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IKZF2 RAPSN CSF1 LTF

1.81e-04149844c9334f319a0c943268e54b6f0c9446736172c3a9
ToppCell10x5'-Liver-Lymphocytic_T_CD4/8-lo-Trm_Tgd|Liver / Manually curated celltypes from each tissue

EFCAB11 GRK4 ZBTB41 ZNF551

2.06e-04154844c6308074468235c88ef4ea43ab155d9f86cbf261
ToppCellfacs-Marrow-Granulocytes-3m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MLH3 GRK4 PDP2 PPIP5K2

2.11e-04155844cd2f3ad4f131588325a667b6724e530d821fbe30
ToppCellfacs-Marrow-Granulocytes-3m-Hematologic-MPP_Fraction_B|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MLH3 GRK4 PDP2 PPIP5K2

2.11e-041558449b26ade19488511c72b64335011d2dcd81e8f167
ToppCellfacs-Marrow-Granulocytes-3m-Hematologic-hematopoietic_stem_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MLH3 GRK4 PDP2 PPIP5K2

2.11e-041558444246709e27703b94529369abbed5763e4002e79d
ToppCell10x5'-blood-Lymphocytic_T_CD4-Trm_Th1/Th17|blood / Manually curated celltypes from each tissue

ADAM23 FAM161A ZNF587 ZNF619

2.22e-04157844c99cb26d831c25038f2aa1b1c0f7ba52facb2e7a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZFP36L2 SLIT3 ZNF333 IL1RAP

2.33e-04159844330ecbba97d47bc818a5e8d1d84b05d056bd831e
ToppCellfacs-Limb_Muscle-forelimb_and_hindlimb|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORCS3 NCAM2 LTF LHX8

2.33e-04159844f7803f7b4e0379ae8256ec53110833bedee7db98
ToppCellfacs-Limb_Muscle-forelimb_and_hindlimb-18m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORCS3 NCAM2 LTF LHX8

2.33e-041598446e2d38e78d2ef7803e8bb154b5c788bf62a41045
ToppCell368C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2|368C / Donor, Lineage, Cell class and subclass (all cells)

IKZF3 ZFP36L2 IKZF1 ZNF551

2.33e-041598447065062fce248e0458932a22dfcc25a5b5a70cbd
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZFP36L2 SLIT3 ZNF333 IL1RAP

2.33e-04159844cbb331eb689d8cea9e1146ba85e0a05d23301c47
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ZC3H7A IKZF2 VWA8 ZBTB42

2.44e-0416184422fea192cd5f6d3544533d8b10e1d74dfedf0f05
ToppCell343B-Lymphocytic-NK_cells-NK_cell_D3|343B / Donor, Lineage, Cell class and subclass (all cells)

ZFP36L2 CLK4 IKZF1 ZNF551

2.56e-041638448a4931c9fdaedcf6c319157821d3556cd25fc9e5
ToppCellPND14-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IKZF2 RAPSN CSF1 CNN2

2.62e-04164844f4de9f18134a06f3d7fcf5b50b8e21c1506e2083
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-Natural_Killer|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IKZF3 ZFP36L2 IKZF1 CNN2

2.62e-04164844e9e5a1462d8ed60b2e5bf603c8c47eb85bce83d5
ToppCellPND14-Immune-Immune_Myeloid-Granulocytic-Basophil|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IKZF2 RAPSN CSF1 CNN2

2.62e-04164844dc22b1fef49c1557a0b63c536eaba574dfcab715
ToppCellE18.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PARP11 IKZF3 RAPSN IKZF1

2.68e-041658440c80abf13409767825ef8a507b498afafa7e89c5
ToppCellE18.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PARP11 IKZF3 RAPSN IKZF1

2.68e-04165844cced77f2d74b07010307d7f4788b8cf3fdaeb91a
ToppCelltumor_Lymph_Node_/_Brain-T/NK_cells-CD8+/CD4+_Mixed_Th|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

ZNF410 ZFP36L2 GRK4 IKZF1

2.80e-04167844c0c944eae0514dc8e00d0c2892a0792e157695ec
ToppCellCOVID-19_Mild-PLT_2|World / Disease Group and Platelet Clusters

IKZF2 FAM161A ZNF558 PLCG1

2.93e-041698446abfdc8b437f19c03b408bedc245059d28c6ba6a
ToppCelldroplet-Lung-nan-3m-Myeloid-basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IKZF2 RAPSN CSF1 IL1RAP

2.93e-04169844da607c1d068038d5a3d1117f6aa6e4c6f3552e97
ToppCelldroplet-Lung-nan-3m-Myeloid-Basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IKZF2 RAPSN CSF1 IL1RAP

2.93e-04169844a14b46231e079a0fd9f3ca13d5d48113be76fd0f
ToppCellSevere-Lymphoid-T-|Severe / Condition, Lineage, Cell class and cell subclass

IKZF3 IKZF1 PLCG1 SPSB3

3.00e-041708445788e1158fde036937d41708e9db3222ca351eb1
ToppCelldroplet-Liver-LIVER-NPC-1m-Lymphocytic-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IKZF3 ZFP36L2 IKZF1 CNN2

3.00e-04170844bcbe5c44ef708c5f01dc7dd9aec7b436e1a62d56
ToppCelldroplet-Liver-Npc-18m-Lymphocytic-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IKZF3 ZFP36L2 IKZF1 CNN2

3.07e-04171844872b3b33cd3893d63c45617db0269692430b0e8b
ToppCell356C-Lymphocytic-ILC-ILC-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CSF1 RPS6KA2 ZNF333 ZNF417

3.07e-041718443d26ef58fe5231373d7df9ac79d225546918cf82
ToppCellBronchial_Biopsy-Immune-Mast_cells|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

ZNF410 IKZF3 CSF1 ZNF154

3.14e-04172844c477008444d2d71071177807870d7455e90c2fad
ToppCellPND01-Immune-Immune_Myeloid-Granulocytic-Basophil|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IKZF2 RAPSN CSF1 DOCK11

3.14e-041728446503e85182eb6e8a40a890e393e9ac5c5350e322
ToppCellfacs-Lung-nan-3m-Lymphocytic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IKZF3 ZFP36L2 DOCK11 IKZF1

3.14e-041728447af0713c40ea48f1e92c859c4fc4d8f0137c4415
ToppCellPND01-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IKZF2 RAPSN CSF1 DOCK11

3.14e-041728443c0bf7200e582ee730af49dcd86446e112226aca
ToppCellPND03-Immune-Immune_Myeloid-Granulocytic-Basophil|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IL31RA IKZF2 RAPSN CSF1

3.21e-041738448ca650542655c27516029e5bace97ff1b9dcc256
ToppCelldroplet-Fat-Bat-18m-Mesenchymal-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MLH3 VWA8 SLC47A1 PLCG1

3.35e-04175844b4f01e7782cdd107d0817ef601891fd3a382bc35
ToppCelldroplet-Fat-Bat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MLH3 VWA8 SLC47A1 PLCG1

3.35e-04175844ef6f811d8e1839f405c3b41090ddf79be57a099f
ToppCelldroplet-Fat-Bat-18m-Mesenchymal|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MLH3 VWA8 SLC47A1 PLCG1

3.35e-041758447f7598d46d10bff1cbea42f950bdde1aaa16e9a4
ToppCellCOVID-19-Heart-VSMC|COVID-19 / Disease (COVID-19 only), tissue and cell type

CACNB2 ADAMTS9 SLIT3 PRDM16

3.35e-041758441125f0d3a5b2388fa77a820dea0288e824d84a82
ToppCelldroplet-Marrow-BM-30m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IKZF2 RAPSN CSF1 PLCG1

3.42e-041768448e4600efeea095a92178cfd26d7c58db7dfc0c80
ToppCellmetastatic_Brain-Endothelial_cells-Lymphatic_ECs|Endothelial_cells / Location, Cell class and cell subclass

IKZF2 CSF1 ZNF670 ZNF417

3.42e-0417684442541dfe20eb29625d47c0bb79bf3c21a2460340
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CACNB2 LHX8 ARHGAP20 ADAMTSL3

3.50e-041778449ec7f1e64312d26d434b3312b58386715dbad644
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CACNB2 LHX8 ARHGAP20 ADAMTSL3

3.50e-04177844016277dfd59b1793fddaaadc2b3f41622d76ce3a
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CACNB2 SLIT3 ADAMTSL3 ASAP1

3.50e-04177844a8625d14682183cf77cb51eaf11bc15a3528f586
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CACNB2 SLIT3 ADAMTSL3 ASAP1

3.50e-041778443645e2f4a48283f290f85c49c3e79e3f58ac9aa6
ToppCelldroplet-Marrow-nan-24m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IKZF2 RAPSN CSF1 ADAMTS9

3.57e-04178844cc0382b0ee1e6c76522e2c86ad1425c45debab5d
ToppCelldroplet-Liver-LIVER-30m-Lymphocytic-NK_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IKZF3 IKZF2 RAPSN CNN2

3.57e-0417884400a5d8f47373be4792bf53914db63a1aedc2d77a
ToppCellB_cells-Naive_B_cells_|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

IKZF2 ADAM23 DSE ZNF681

3.57e-0417884471ac2eca5cf13a91f86b80690748b0788392dcfc
ToppCellCOVID-19-Heart-VSMC|Heart / Disease (COVID-19 only), tissue and cell type

CACNB2 ADAMTS9 SLIT3 PRDM16

3.65e-04179844a69ad6912b5c10bb9f9d800f724c792341e9bab1
ToppCellmetastatic_Brain-Endothelial_cells-Lymphatic_ECs|metastatic_Brain / Location, Cell class and cell subclass

IKZF2 ZNF670 ADAMTS9 ZNF417

3.65e-0417984456fe381ffbaba3a4f2f587a3e367b0d11fbd4a2a
ToppCellCOVID-19-Heart-EC_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

ADAMTS9 PRDM16 NOS3 ADIPOR2

3.65e-041798442a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNB2 SLIT3 SORCS3 ARHGAP20

3.72e-0418084408ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCellLV|World / Chamber and Cluster_Paper

CACNB2 VWA8 ADAM23 PRDM16

3.72e-041808445ac6f485a58bb29462fec02dfbe8eb70864eafe3
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNB2 SLIT3 SORCS3 ARHGAP20

3.72e-041808449b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNB2 SLIT3 SORCS3 ARHGAP20

3.80e-041818449e7d0f1afb8d9bc5a209ddb5314df3a25a0274d9
ToppCellSevere-Lymphoid-T-innate_T|Severe / Condition, Lineage, Cell class and cell subclass

IKZF3 ZFP36L2 IKZF1 PLCG1

3.80e-0418184450ab8562552339d97e4f19aa6ae49fd797da492e
ToppCellRA-13._Vascular_Smooth_Muscle|RA / Chamber and Cluster_Paper

CACNB2 ADAMTS9 SLIT3 PRDM16

3.96e-04183844818fd886e0188091310825f9145fa53328f2c979
ToppCellLA-11._Adipocyte|World / Chamber and Cluster_Paper

DOCK11 ARHGAP20 LRP1B ADIPOR2

3.96e-04183844b177be283e1553fb1f69a346f1ba79ad00297fa2
ToppCellLA-11._Adipocyte|LA / Chamber and Cluster_Paper

DOCK11 ARHGAP20 LRP1B ADIPOR2

3.96e-041838443f9011976782fa8aa95cdd6f00f07a91094d411b
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-5_PVALB_TRIM67|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS9 DOCK11 RPS6KA2 SLC47A1

4.05e-041848447f6c8912677764d438ab0555faca344d74c2f483
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLIT3 LHX8 ARHGAP20 ADAMTSL3

4.05e-04184844e061e85c4bb19f49f6451ddd7a9077d7378ee365
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZFP36L2 SORCS3 NKTR PLCG1

4.05e-041848445350b58aa9979631228835d11eb45ddf81d08bff
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

IKZF3 ZNF587 PDP2 MACF1

4.13e-04185844a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D231|Adult / Lineage, Cell type, age group and donor

CACNB2 P2RX2 SLIT3 ADAMTSL3

4.13e-04185844fb6bd7e849ecf4ed9cd9c4e2a946a2d12d62f804
ToppCellMesenchymal_cells-Osteo-CAR|World / Lineage and Cell class

CSF1 ADAMTS9 P2RX2 SLIT3

4.13e-0418584416f1588893d09c864e0cb4f837a1b972a1a57baa
ToppCelldroplet-Thymus-nan-3m-Lymphocytic-double_negative_T_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IKZF2 RAPSN IKZF1 CNN2

4.22e-0418684411929e36d8c9b4c4bc2f5e912f139f474f91ab00
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

IKZF3 IKZF2 ADAM23 IKZF1

4.22e-041868449d576dce2c5deefef1adda16c6da7055c8d57f8f
ToppCelldroplet-Liver-LIVER-NPC-1m-Lymphocytic-NK_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IKZF3 ZFP36L2 IKZF1 CNN2

4.22e-04186844629b19447a63412cf1468160a0fedb5dbe02fd72
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-T_Cell-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

IKZF3 IKZF2 ADAM23 IKZF1

4.22e-04186844bd3bd022b575d9b0ef90d50a5cb874085a827b77
ToppCelldroplet-Liver-LIVER-NPC-1m-Lymphocytic|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IKZF3 ZFP36L2 IKZF1 CNN2

4.22e-041868448df32cde77bb0b3e2f37a9664e7b72ec99697395
DrugSotalol hydrochloride [959-24-0]; Down 200; 13uM; HL60; HT_HG-U133A

ZNF10 ZNF410 DCAF15 MLH3 PPIL2 NKTR IL1RAP

7.88e-061958472918_DN
DrugAntipyrine [60-80-0]; Down 200; 21.2uM; PC3; HT_HG-U133A

DCAF15 RAPSN EFCAB11 ZFP36L2 ADAM23 PPIL2 SPSB3

7.88e-061958474251_DN
DrugEpitiostanol [2363-58-8]; Down 200; 13uM; HL60; HT_HG-U133A

DCAF15 MLH3 CSF1 ADAM23 PPIL2 IKZF1 DSE

8.14e-061968472922_DN
DrugMetergoline [17692-51-2]; Down 200; 10uM; PC3; HT_HG-U133A

RAPSN ZFP36L2 ADAM23 GRK4 IKZF1 NKTR PLCG1

8.14e-061968476744_DN
DiseaseCongenital dyserythropoietic anemia

LPIN2 SEC23B

7.59e-055822C0002876
Diseasedisorder of pharynx

ADAM23 IKZF1 ZNF417

2.88e-0446823MONDO_0020592
Diseasediastolic blood pressure, alcohol drinking

CEP170 CACNB2 SLIT3 NOS3

3.34e-04118824EFO_0004329, EFO_0006336
DiseaseL2 Acute Lymphoblastic Leukemia

IKZF3 IKZF2 IKZF1

3.69e-0450823C0023453
DiseaseChildhood Acute Lymphoblastic Leukemia

IKZF3 IKZF2 IKZF1

4.14e-0452823C0023452
Diseasephosphatidylcholine 40:7 measurement

RAPSN ADAM23

5.83e-0413822EFO_0021477
DiseasePrecursor Cell Lymphoblastic Leukemia Lymphoma

IKZF3 IKZF2 IKZF1

6.63e-0461823C1961102
Diseaseglucose measurement

OR4C3 RAPSN ZFP36L2 VWA8 PLCG1 PRDM16

6.74e-04380826EFO_0004468
DiseaseAPOE carrier status, dementia

ZIC5 RPS6KA2 PPIL2

6.95e-0462823EFO_0007659, MONDO_0001627
DiseaseGastro-enteropancreatic neuroendocrine tumor

IKZF3 IKZF1

7.82e-0415822C2930967
DiseaseAntihypertensive use measurement

CACNB2 PDP2 SORCS3 PRDM16 NOS3

8.74e-04265825EFO_0009927
DiseaseNecrotizing Enterocolitis

LTF NOS3

1.01e-0317822C0520459
Diseaseessential hypertension (is_implicated_in)

GRK4 NOS3

1.13e-0318822DOID:10825 (is_implicated_in)
Diseasespine bone size

RAPSN ADAMTSL3

1.13e-0318822EFO_0004508
Diseaseasthma

IKZF3 RAPSN ADAMTS9 IKZF1 ADAMTSL3 MUC2 PRDM16 LRP1B

1.15e-03751828MONDO_0004979
Diseaseplatelet component distribution width

RAPSN MTF1 MACF1 IKZF1 ZNF333 PRDM16 NOS3 ASAP1

1.19e-03755828EFO_0007984
Diseasefamilial hyperlipidemia (biomarker_via_orthology)

SERPINC1 NOS3

1.27e-0319822DOID:1168 (biomarker_via_orthology)
Diseasemosaic loss of chromosome Y measurement

TAF8 IKZF1 PRDM16

1.46e-0380823EFO_0007783
Diseaselevel of Phosphatidylinositol (18:0_18:2) in blood serum

RAPSN FAM161A

1.55e-0321822OBA_2045156
Diseasesevere acute respiratory syndrome, COVID-19

IKZF2 ADAM23 RPS6KA2 GRK4 NCAM2 LRP1B

1.55e-03447826EFO_0000694, MONDO_0100096
Diseaseneutrophil percentage of leukocytes

ZC3H7A TAF8 RAPSN ZFP36L2 SLC47A1 IKZF1 CNN2

1.55e-03610827EFO_0007990
Diseaseserum iron measurement

IKZF1 LRP1B ASAP1

1.79e-0386823EFO_0006332
Diseaseinsulin sensitivity measurement

RAPSN CSF1

1.86e-0323822EFO_0004471
Diseasecongenital diaphragmatic hernia (biomarker_via_orthology)

SLIT3 NOS3

2.02e-0324822DOID:3827 (biomarker_via_orthology)
Diseasemean platelet volume

RAPSN DOCK11 GRK4 IKZF1 PRDM16 NOS3 CNN2 DSE ASAP1

2.08e-031020829EFO_0004584
Diseaselymphocyte percentage of leukocytes

TAF8 IKZF3 RAPSN ZFP36L2 SLC47A1 IKZF1 PRDM16

2.53e-03665827EFO_0007993
Diseaseoptic disc size measurement

MACF1 ADAMTSL3 PRDM16 LRP1B

2.59e-03205824EFO_0004832
DiseaseAlzheimer disease, APOE carrier status

ZIC5 RPS6KA2 PPIL2

2.60e-0398823EFO_0007659, MONDO_0004975
Diseaseupper respiratory tract disorder

ADAM23 IKZF1

2.75e-0328822MONDO_0004867

Protein segments in the cluster

PeptideGeneStartEntry
RKSFTSLYKDRCSTG

CEP170

956

Q5SW79
VSHSRKFSKCSILEY

ADAM23

466

O75077
DGTSRFTCKGKSIYH

ADH6

126

P28332
TRKELFYKADGESCS

SERPINC1

266

P01008
SRHKSKDRYCEKDGE

CACNB2

626

Q08289
SCAYLDKKHTIFGRV

PPIL2

386

Q13356
CHSEGVSRLFSKLDY

ADIPOR2

206

Q86V24
RSNEKLCEFHKTISY

RAPSN

91

Q13702
KLRSDEKHRDVCYSI

FBXO21

491

O94952
SDEDHCGGKLTYKAR

LRP1B

3746

Q9NZR2
NRRKDTKEIYTHFTC

GNAI3

311

P08754
KRTYAFGEKHDNCTT

IL31RA

56

Q8NI17
LKRSYVCHARSAKGE

IL1RAP

326

Q9NPH3
VEKVGNRYFTSKCHS

MLH3

66

Q9UHC1
KIFCRTYDIHDPKSS

ODR4

146

Q5SWX8
DCRGSYKEFAVHLKR

MUC2

66

Q02817
SKYKHDLAASCQGRV

DSE

511

Q9UL01
CLRKQRHGSDSEYTE

EPHB3

581

P54753
RTSLGRHTSCYIKDK

LHX8

106

Q68G74
KESTKERHGYCTLGE

FBXO25

91

Q8TCJ0
CGRSYKQRSSLEEHK

IKZF1

206

Q13422
CGRSYKQRSSLEEHK

IKZF2

201

Q9UKS7
RKYSCDHNTSLSRLE

MACF1

811

Q9UPN3
HKSYKIRFNSISCSD

NOS3

606

P29474
AAYSSRFCKDDIKHG

PARP11

241

Q9NR21
ADRTDGYLKRCTFHE

P2RX2

216

Q9UBL9
GFTLCKAYRHTSTEE

PDP2

56

Q9P2J9
SKCSRKYITEFLDTG

ADAMTS9

476

Q9P2N4
SKCHEEGLDSYLRSF

DOCK11

901

Q5JSL3
SLRLKSCFTKDYEEH

CSF1

116

P09603
ECKTGFRHLYKITSI

DPP8

471

Q6V1X1
KYVDHRFSRKTCSTS

ASAP1

546

Q9ULH1
RDIESGYRIHCSKSS

CLK4

91

Q9HAZ1
YIRCKDTGFHAAEKR

FAM161A

211

Q3B820
RHSIEKDYSSLCDKQ

GRK4

46

P32298
FCGRSYKQRSSLEEH

IKZF3

206

Q9UKT9
VFKACDEDHKGYLSR

EFCAB11

26

Q9BUY7
SKGAVVATYRKTHLC

NIT1

151

Q86X76
HKGCSLKVLADSERY

DCAF15

581

Q66K64
YSLRSHSADGRCKAL

OR4C3

221

Q8NH37
RGIYSKKQHKTSCEA

ARHGAP20

861

Q9P2F6
EIGRSAKSYCEHTAR

TAF8

71

Q7Z7C8
TECLARLHGKTTYEK

LTF

666

P02788
LHSKYVKGRDRSSCV

NKTR

781

P30414
VDYKSIFSRHCTKED

SORCS3

686

Q9UPU3
KSSATGHCLKIYRTF

TAF1L

1176

Q8IZX4
CSKYFTTLSDLRKHI

MTF1

236

Q14872
SKLDLRRHKKYTCGS

PRDM16

241

Q9HAZ2
SDVDLDKYRHTFCSL

SPSB3

171

Q6PJ21
HELSCEGISKSYVFR

SEC23B

176

Q15437
SCKDHVGYIFTTDRD

SLC47A1

356

Q96FL8
TRRHIYDTKLGTDKC

CNN2

226

Q99439
KKFRCSGSEDYRSRF

SLIT3

481

O75094
EECGKAFYRSSHLTE

ZNF876P

66

Q49A33
CGKAFAYTSSLRRHE

ZNF700

311

Q9H0M5
CEKAFSYSGDLRVHS

ZNF540

416

Q8NDQ6
KECGKAYSFSSSLRI

ZNF77

411

Q15935
HIKDVKLSDSGRYDC

NCAM2

366

O15394
DCGKTFRKSSYLTQH

ZNF558

296

Q96NG5
KECGKSFRYRSHLTE

ZNF587

411

Q96SQ5
CGRSFAEYSSLRKHL

ZNF410

316

Q86VK4
CDKTFDRIGKYESHT

ZBTB41

366

Q5SVQ8
KECGKSFRYRSHLTE

ZNF417

411

Q8TAU3
PYECSDREKAFIHKS

ZNF551

306

Q7Z340
SYAISFRAEGKIKHC

PLCG1

701

P19174
CEKSFRYSSDLIRHE

ZNF333

371

Q96JL9
TEDKFYLSDEHGKCR

ZNF658

376

Q5TYW1
KTFSCTYTLKRHERT

ZBTB42

341

B2RXF5
IQFARTHTGDKSYKC

ZNF10

226

P21506
TTVKYSKIRSFHGQC

ZC3H7A

616

Q8IWR0
CGKAFYRSSKLTEHK

ZNF681

511

Q96N22
ECGKFFPYSSSLRKH

ZNF154

361

Q13106
YARTHRKKLTSSGCI

PPIP5K2

1081

O43314
LHKRSGTDTSFYRGK

VWA8

1391

A3KMH1
KYKTELCRTFHTIGF

ZFP36L2

191

P47974
DCGKTFSYNSKLIRH

ZNF619

276

Q8N2I2
SGRKYSDHCEARASR

ZFTA

76

C9JLR9
KKCGKAYTRSSHLTR

ZNF669

421

Q96BR6
KAFKYSSNLCEHERT

ZNF670

316

Q9BS34
DSIFSKDKRKHCGYT

USP54

586

Q70EL1
RGCDKSYTHPSSLRK

ZIC5

556

Q96T25
EGYHSRQVTCKRTKA

ADAMTSL3

1501

P82987
SKEAIDHDKRAYSFC

RPS6KA2

206

Q15349
ERTKGNKSSYHRLSE

LPIN2

841

Q92539