Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase I	ERBB2 UBTFL6 MYO1C DHX33	1.67e-05	37	86	4	GO:0045943
GeneOntologyCellularComponent	apical plasma membrane urothelial plaque	UPK1A UPK1B	9.75e-05	4	85	2	GO:0120001
GeneOntologyCellularComponent	U2AF complex	ZRSR2P1 ZRSR2	3.39e-04	7	85	2	GO:0089701
Domain	U2AF_small	ZRSR2P1 ZRSR2	1.93e-04	5	83	2	IPR009145
Domain	GS	TGFBR1 BMPR1A	4.04e-04	7	83	2	SM00467
Domain	GS_dom	TGFBR1 BMPR1A	4.04e-04	7	83	2	IPR003605
Domain	GS	TGFBR1 BMPR1A	4.04e-04	7	83	2	PS51256
Domain	TGF_beta_GS	TGFBR1 BMPR1A	4.04e-04	7	83	2	PF08515
Domain	Activin_recp	TGFBR1 BMPR1A	8.58e-04	10	83	2	IPR000472
Domain	Activin_recp	TGFBR1 BMPR1A	8.58e-04	10	83	2	PF01064
Domain	Znf_CXXC	MBD1 KDM2A	1.05e-03	11	83	2	IPR002857
Domain	ZF_CXXC	MBD1 KDM2A	1.05e-03	11	83	2	PS51058
Domain	zf-CXXC	MBD1 KDM2A	1.05e-03	11	83	2	PF02008
Domain	TGFB_receptor	TGFBR1 BMPR1A	1.25e-03	12	83	2	IPR000333
Domain	Leu-rich_rpt_Cys-con_subtyp	AMN1 KDM2A	3.18e-03	19	83	2	IPR006553
Domain	LRR_CC	AMN1 KDM2A	3.18e-03	19	83	2	SM00367
Domain	L_dom-like	NLRP11 ERBB2 AMN1 NXF2 KDM2A PRAMEF6	3.41e-03	328	83	6	IPR032675
Domain	RRM_dom	ZRSR2P1 ZRSR2 NXF2 RBM5 DND1	3.42e-03	227	83	5	IPR000504
Domain	RRM	ZRSR2P1 ZRSR2 NXF2 RBM5 DND1	3.61e-03	230	83	5	PS50102
Domain	Znf_FYVE_PHD	KDM2A RFFL RIMS2 SP140	4.18e-03	147	83	4	IPR011011
Domain	zf-DHHC	ZDHHC21 ZDHHC5	4.65e-03	23	83	2	PF01529
Domain	Metal_Hydrolase	AMPD2 CAD	5.05e-03	24	83	2	IPR032466
Pubmed	ZRSR1 co-operates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells.	ZRSR2P1 ZRSR2	6.04e-06	2	86	2	33691379
Pubmed	Precision glycocalyx editing as a strategy for cancer immunotherapy.	ERBB2 SIGLEC1	6.04e-06	2	86	2	27551071
Pubmed	[Correlation analysis of vascular endothelial growth factor-C expression and clinicopathology in breast cancer].	VEGFC ERBB2	6.04e-06	2	86	2	19923084
Pubmed	Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in mice.	LDLR FAAH	6.04e-06	2	86	2	20484813
Pubmed	Gene knockout of RNA binding motif 5 in the brain alters RIMS2 protein homeostasis in the cerebellum and Hippocampus and exacerbates behavioral deficits after a TBI in mice.	RBM5 RIMS2	6.04e-06	2	86	2	38218585
Pubmed	Zrsr2 and functional U12-dependent spliceosome are necessary for follicular development.	ZRSR2P1 ZRSR2	6.04e-06	2	86	2	35198906
Pubmed	Distinct glycan structures of uroplakins Ia and Ib: structural basis for the selective binding of FimH adhesin to uroplakin Ia.	UPK1A UPK1B	6.04e-06	2	86	2	16567801
Pubmed	Relation between transforming growth factor-β1 expression, its receptor and clinicopathological factors and survival in HER2-negative gastric cancers.	TGFBR1 ERBB2	1.81e-05	3	86	2	22015652
Pubmed	Overexpression of Her-2/NEU in epithelial ovarian carcinoma induces vascular endothelial growth factor C by activating NF-kappa B: implications for malignant ascites formation and tumor lymphangiogenesis.	VEGFC ERBB2	1.81e-05	3	86	2	14966375
Pubmed	Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1.	ZRSR2P1 ZRSR2	1.81e-05	3	86	2	8586425
Pubmed	Transdifferentiation of alveolar epithelial type II to type I cells is controlled by opposing TGF-β and BMP signaling.	TGFBR1 BMPR1A	1.81e-05	3	86	2	23831617
Pubmed	Roles for the MH2 domain of Smad7 in the specific inhibition of transforming growth factor-beta superfamily signaling.	TGFBR1 BMPR1A	1.81e-05	3	86	2	15148321
Pubmed	Concurrent Zrsr2 mutation and Tet2 loss promote myelodysplastic neoplasm in mice.	ZRSR2P1 ZRSR2	1.81e-05	3	86	2	36030305
Pubmed	Selective interactions of UPIa and UPIb, two members of the transmembrane 4 superfamily, with distinct single transmembrane-domained proteins in differentiated urothelial cells.	UPK1A UPK1B	1.81e-05	3	86	2	8530366
Pubmed	Elevated tumor LDLR expression accelerates LDL cholesterol-mediated breast cancer growth in mouse models of hyperlipidemia.	ERBB2 LDLR	1.81e-05	3	86	2	28759039
Pubmed	Prognostic Significance of VEGFC and VEGFR1 mRNA Expression According to HER2 Status in Breast Cancer: A Study of Primary Tumors from Patients with High-risk Early Breast Cancer Participating in a Randomized Hellenic Cooperative Oncology Group Trial.	VEGFC ERBB2	1.81e-05	3	86	2	26124351
Pubmed	Relationship between cyclooxygenase-2 and human epidermal growth factor receptor 2 in vascular endothelial growth factor C up-regulation and lymphangiogenesis in human breast cancer.	VEGFC ERBB2	1.81e-05	3	86	2	20608938
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	DUS2 ZRSR2P1 AGO3 ZRSR2 RBM5 DND1 PRAMEF6	2.53e-05	347	86	7	16033648
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	AMPD2 SPAST MYO1C SWAP70 ACADVL ELP6 KDM2A	3.20e-05	360	86	7	33111431
Pubmed	Mouse U2af1-rs1 is a neomorphic imprinted gene.	ZRSR2P1 ZRSR2	3.61e-05	4	86	2	9001233
Pubmed	Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum.	UPK1A UPK1B	3.61e-05	4	86	2	12475947
Pubmed	Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors.	TGFBR1 BMPR1A	3.61e-05	4	86	2	9738003
Pubmed	Loss of Rictor in Monocyte/Macrophages Suppresses Their Proliferation and Viability Reducing Atherosclerosis in LDLR Null Mice.	RPTOR LDLR	3.61e-05	4	86	2	29487597
Pubmed	Mammalian uroplakins. A group of highly conserved urothelial differentiation-related membrane proteins.	UPK1A UPK1B	3.61e-05	4	86	2	8175808
Pubmed	Expression and localization of four uroplakins in urothelial preneoplastic lesions.	UPK1A UPK1B	3.61e-05	4	86	2	21853341
Pubmed	Cloning and mapping of the U2af1-rs2 gene with a high transmission distortion in interspecific backcross progeny.	ZRSR2P1 ZRSR2	3.61e-05	4	86	2	7558001
Pubmed	Vascular smooth muscle cells express multiple type I receptors for TGF-beta, activin, and bone morphogenetic proteins.	TGFBR1 BMPR1A	3.61e-05	4	86	2	8605036
Pubmed	Uroplakin gene expression by normal and neoplastic human urothelium.	UPK1A UPK1B	3.61e-05	4	86	2	9846985
Pubmed	Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma.	VEGFC ERBB2	3.61e-05	4	86	2	14744769
Pubmed	Increased Level of Vascular Endothelial Growth Factors by 4-hexylresorcinol is Mediated by Transforming Growth Factor-β1 and Accelerates Capillary Regeneration in the Burns in Diabetic Animals.	VEGFC TGFBR1	3.61e-05	4	86	2	32423083
Pubmed	RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation.	RBM5 NUMB	3.61e-05	4	86	2	24332178
Pubmed	Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract.	UPK1A UPK1B	3.61e-05	4	86	2	10514386
Pubmed	Structure of the major membrane protein complex from urinary bladder epithelial cells by cryo-electron crystallography.	UPK1A UPK1B	3.61e-05	4	86	2	11718558
Pubmed	The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.	TGFBR1 BMPR1A	6.01e-05	5	86	2	9136927
Pubmed	14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition.	TGFBR1 ERBB2	6.01e-05	5	86	2	19732720
Pubmed	The clathrin adaptor proteins ARH, Dab2, and numb play distinct roles in Niemann-Pick C1-Like 1 versus low density lipoprotein receptor-mediated cholesterol uptake.	NUMB LDLR	6.01e-05	5	86	2	25331956
Pubmed	MAL facilitates the incorporation of exocytic uroplakin-delivering vesicles into the apical membrane of urothelial umbrella cells.	UPK1A UPK1B	6.01e-05	5	86	2	22323295
Pubmed	Macrophage TGF-β signaling is critical for wound healing with heterotopic ossification after trauma.	TGFBR1 SIGLEC1	6.01e-05	5	86	2	36099022
Pubmed	BMP signaling is essential in neonatal surfactant production during respiratory adaptation.	BMPR1A SFTPB	6.01e-05	5	86	2	27190064
Pubmed	NUMB facilitates autophagy initiation through targeting SCFβ-TrCP2 complex.	RPTOR NUMB	6.01e-05	5	86	2	35017646
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	ZDHHC21 TGFBR1 ERBB2 BMPR1A GINM1 AGO3 UPK1B ZDHHC5 RBM5 ALG11 LDLR	6.13e-05	1061	86	11	33845483
Pubmed	Disruption of mammalian target of rapamycin complex 1 in macrophages decreases chemokine gene expression and atherosclerosis.	RPTOR LDLR	9.01e-05	6	86	2	24687132
Pubmed	The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity.	SWAP70 RPTOR	9.01e-05	6	86	2	28811467
Pubmed	LRP1 Deficiency in Vascular SMC Leads to Pulmonary Arterial Hypertension That Is Reversed by PPARγ Activation.	TGFBR1 LDLR	9.01e-05	6	86	2	31023188
Pubmed	Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition.	ZRSR2P1 ZRSR2	9.01e-05	6	86	2	33846634
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ERBB2 BMPR1A AGO3 MYO1C RPTOR MBD1 ADNP2 SIGLEC1 LDLR PHIP SP140	9.59e-05	1116	86	11	31753913
Pubmed	Mesenchymal FGFR1 and FGFR2 control patterning of the ureteric mesenchyme by balancing SHH and BMP4 signaling.	BMPR1A UPK1A UPK1B	1.07e-04	37	86	3	36094016
Pubmed	SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.	TGFBR1 BMPR1A	1.26e-04	7	86	2	12065756
Pubmed	A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA.	ZRSR2P1 ZRSR2	1.26e-04	7	86	2	9237760
Pubmed	Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab.	TGFBR1 ERBB2	1.26e-04	7	86	2	18625725
Pubmed	Stretch-induced fetal type II cell differentiation is mediated via ErbB1-ErbB4 interactions.	ERBB2 SFTPB	1.26e-04	7	86	2	22493501
Pubmed	SELENOPROTEINS. CRL2 aids elimination of truncated selenoproteins produced by failed UGA/Sec decoding.	APPBP2 PRAMEF6	1.26e-04	7	86	2	26138980
Pubmed	Defining the membrane proteome of NK cells.	CAD AGO3 MYO1C MARCHF5 ZDHHC5 ALG11 RFFL EIF3D ECPAS LDLR KIF11	1.43e-04	1168	86	11	19946888
Pubmed	Allelic variants between mouse substrains BALB/cJ and BALB/cByJ influence mononuclear cardiomyocyte composition and cardiomyocyte nuclear ploidy.	ZRSR2P1 ZRSR2	1.68e-04	8	86	2	32371981
Pubmed	Smad7 inhibits transforming growth factor-beta family type i receptors through two distinct modes of interaction.	TGFBR1 BMPR1A	1.68e-04	8	86	2	20663871
Pubmed	Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes.	TGFBR1 BMPR1A	2.15e-04	9	86	2	9389648
Pubmed	Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads.	TGFBR1 BMPR1A	2.15e-04	9	86	2	12857866
Pubmed	Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis.	BMPR1A WNT2	2.15e-04	9	86	2	8674409
Pubmed	Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice.	ZRSR2P1 ZRSR2 IFT80	2.19e-04	47	86	3	29617656
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	ERBB2 BMPR1A CAD NUMB RIMS2 PHIP	2.68e-04	358	86	6	32460013
Pubmed	Expression of signaling components in embryonic eyelid epithelium.	ERBB2 BMPR1A	2.68e-04	10	86	2	24498290
Pubmed	Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1.	TGFBR1 BMPR1A	2.68e-04	10	86	2	15611116
Pubmed	RLP, a novel Ras-like protein, is an immediate-early transforming growth factor-beta (TGF-beta) target gene that negatively regulates transcriptional activity induced by TGF-beta.	TGFBR1 BMPR1A	2.68e-04	10	86	2	15239668
Pubmed	β-Catenin maintains lung epithelial progenitors after lung specification.	TGFBR1 BMPR1A	2.68e-04	10	86	2	29440304
Pubmed	DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.	MBD1 KDM2A	2.68e-04	10	86	2	29276034
Pubmed	Reduced mTORC1-signaling in retinal ganglion cells leads to vascular retinopathy.	VEGFC RPTOR	3.28e-04	11	86	2	34148274
Pubmed	Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.	TGFBR1 BMPR1A	3.28e-04	11	86	2	7791754
Pubmed	Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.	TGFBR1 BMPR1A	3.28e-04	11	86	2	19758997
Pubmed	Lysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradation.	BMPR1A LAPTM5	3.28e-04	11	86	2	35842443
Pubmed	Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis.	SFTPB WNT2	3.28e-04	11	86	2	9006067
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ERBB2 SPAST FLYWCH1 RPTOR IFT80 ECPAS RIMS2	3.45e-04	529	86	7	14621295
Pubmed	Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization.	TGFBR1 BMPR1A	3.93e-04	12	86	2	25872870
Pubmed	Chromosomal localization of uroplakin genes of cattle and mice.	UPK1A UPK1B	3.93e-04	12	86	2	8281015
Pubmed	A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components.	MARCHF5 KDM2A ECPAS	4.51e-04	60	86	3	20682791
Pubmed	cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner.	ACADVL RPTOR	4.63e-04	13	86	2	18337751
Pubmed	Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone.	TGFBR1 BMPR1A	4.63e-04	13	86	2	11278302
Pubmed	Nuclear factor I-B (Nfib) deficient mice have severe lung hypoplasia.	TGFBR1 SFTPB	4.63e-04	13	86	2	11850179
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	ERBB2 JTB MYO1C ACADVL MYO9A MBD1 NUMB IFT80 KIF11	4.73e-04	925	86	9	28986522
Pubmed	TSC-22 promotes transforming growth factor β-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.	TGFBR1 BMPR1A	5.39e-04	14	86	2	21791611
Pubmed	Identification of host proteins required for HIV infection through a functional genomic screen.	SPAST AGO3 DHX33 KCNIP3 LAPTM5	5.86e-04	272	86	5	18187620
Pubmed	A large-scale candidate gene association study of age at menarche and age at natural menopause.	TGFBR1 BMPR1A SPAST SSTR1 LDLR	6.16e-04	275	86	5	20734064
Pubmed	Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS.	FLYWCH1 MBD1 RBM5	6.51e-04	68	86	3	36966392
Pubmed	Brg1 determines urothelial cell fate during ureter development.	UPK1A UPK1B	7.09e-04	16	86	2	23449535
Pubmed	Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system.	ZDHHC21 ZDHHC5	7.09e-04	16	86	2	23034182
Pubmed	Indispensable role of factor for adipocyte differentiation 104 (fad104) in lung maturation.	VEGFC SFTPB	7.09e-04	16	86	2	21704616
Pubmed	Wnt2 signaling is necessary and sufficient to activate the airway smooth muscle program in the lung by regulating myocardin/Mrtf-B and Fgf10 expression.	VEGFC WNT2	8.02e-04	17	86	2	21704027
Pubmed	Expression levels of endoglin distinctively identify hematopoietic and endothelial progeny at different stages of yolk sac hematopoiesis.	TGFBR1 BMPR1A	8.02e-04	17	86	2	23712751
Pubmed	Comparative mapping of the imprinted U2afbpL gene on mouse chromosome 11 and human chromosome 5.	ZRSR2P1 ZRSR2	8.02e-04	17	86	2	7956352
Pubmed	Fibroproliferative response to urothelial failure obliterates the ureter lumen in a mouse model of prenatal congenital obstructive nephropathy.	UPK1A UPK1B	8.02e-04	17	86	2	27511831
Pubmed	Deletion of STK40 protein in mice causes respiratory failure and death at birth.	SFTPB WNT2	9.01e-04	18	86	2	23293024
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	AGO3 MYO9A MARCHF5 MBD1 DHX33 IFT80 BLZF1 FHIP1A PRAMEF6 LAPTM5	9.84e-04	1242	86	10	30973865
Pubmed	Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation.	ERBB2 NUMB	1.01e-03	19	86	2	28067668
Pubmed	Prenatal lung epithelial cell-specific abrogation of Alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation.	BMPR1A SFTPB	1.01e-03	19	86	2	18258849
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	ERBB2 KIAA0319L ZDHHC5 NUMB	1.06e-03	180	86	4	35198878
Pubmed	A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration.	SFTPB WNT2	1.12e-03	20	86	2	18536717
Pubmed	Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins.	ZDHHC21 ZDHHC5	1.12e-03	20	86	2	16647879
Pubmed	Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system.	ERBB2 RPTOR	1.23e-03	21	86	2	28880149
Pubmed	Signaling via Alk5 controls the ontogeny of lung Clara cells.	TGFBR1 SFTPB	1.23e-03	21	86	2	20147383
Pubmed	Pancreatic islet and progenitor cell surface markers with cell sorting potential.	TGFBR1 JTB LDLR	1.29e-03	86	86	3	21947380
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	AMPD2 ERBB2 SPAST MYO9A RPTOR MBD1 NUMB KIF11	1.32e-03	861	86	8	36931259
GeneFamily	Type 1 receptor serine/threonine kinases	TGFBR1 BMPR1A	2.33e-04	7	61	2	345
GeneFamily	Zinc fingers CXXC-type	MBD1 KDM2A	7.23e-04	12	61	2	136
GeneFamily	WD repeat domain containing	FBXW10B RPTOR TLE6 IFT80 PHIP	1.89e-03	262	61	5	362
GeneFamily	Zinc fingers DHHC-type\|Ankyrin repeat domain containing	ZDHHC21 ZDHHC5	2.95e-03	24	61	2	76
CoexpressionAtlas	dev gonad_e12.5_F_GermCellOvary_Oct_top-relative-expression-ranked_1000	PHKA2 CAD MEIOC SWAP70 ZRSR2 ENPP3 ZNF451 CCDC150 METTL25 DND1 RIMS2 ATP10A KIF11	1.51e-05	822	82	13	gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_1000
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_only / Treatment groups by lineage, cell group, cell type	PHKA2 ERBB2 SFTPB MYO9A LDLR FAAH	2.50e-06	200	86	6	2dadf317a42a7e27cc1fac74f91b806c93a57108
ToppCell	PND10-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZDHHC21 FUT10 DGKG KIF11 LAPTM5	1.97e-05	170	86	5	7534ac69ca3a378df78d61c284e89bc96a71a4a8
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B0\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	B3GALT2 FLYWCH1 SFTPB RFFL GFER	3.04e-05	186	86	5	74c238759c5d3fd39127ec0060d0c2cb16b326d4
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SFTPB MYO9A LDLR PHIP FAAH	4.00e-05	197	86	5	3d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCell	NS-critical-LOC-Epithelial-Secretory_LYPD2\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	VEGFC ERBB2 RNF152 UPK1B FER1L6	4.09e-05	198	86	5	4a481e1edb80b950c823ed926842cd5132cfb27f
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AFAP1L2 DGKG SSTR1 KCNIP3 LDLR	4.19e-05	199	86	5	333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AFAP1L2 DGKG SSTR1 KCNIP3 LDLR	4.19e-05	199	86	5	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AFAP1L2 DGKG SSTR1 KCNIP3 LDLR	4.19e-05	199	86	5	e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCell	COVID-19-lung\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SFTPB SIGLEC1 ATP10A ZNF710 LAPTM5	4.19e-05	199	86	5	155b03b859157013e9142e9248551369127d9204
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-B-B_intermediate\|COVID-19_Severe / Disease, condition lineage and cell class	ZDHHC21 DUS2 MYO1C SWAP70 SP140	4.19e-05	199	86	5	ad3c369a67926725917b771094f82ca6dd2af783
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ERBB2 SFTPB MYO9A IFT80 FAAH	4.29e-05	200	86	5	ddfb1f006365bf16203ee49f20200f68220cc288
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Interneuron\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	AFAP1L2 RNF152 WNT2 GPR85 RIMS2	4.29e-05	200	86	5	a6500d0d2e8bcac92381ab771dbdee66b0e1d48e
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ERBB2 SFTPB MYO9A IFT80 FAAH	4.29e-05	200	86	5	8683445ad5b70748c4a1f12eb77d47623085147e
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AFAP1L2 DGKG SSTR1 KCNIP3 LDLR	4.29e-05	200	86	5	ad777683adeb2ce45ade570386235e311fa7ea2d
Disease	osteoarthritis (implicated_via_orthology)	TGFBR1 BMPR1A	7.64e-04	15	81	2	DOID:8398 (implicated_via_orthology)
Disease	breast carcinoma (is_implicated_in)	VEGFC WNT2	2.14e-03	25	81	2	DOID:3459 (is_implicated_in)
Disease	nephroblastoma (is_marker_for)	VEGFC ERBB2	3.94e-03	34	81	2	DOID:2154 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
MAAGERSWCLCKLLR	ALG11	1	Q2TAA5
VKCWMIDSECRPRFR	ERBB2	956	P04626
WRCLKFVMRKLTGRC	ELMOD1	21	Q8N336
RVSQLLDLCLWCFMK	AMN1	6	Q8IY45
ELMRDARICAFLWRK	AFAP1L2	171	Q8N4X5
MLHWFRAVECCVRLL	APPBP2	156	Q92624
CRATVCWELKGNMVV	ELP6	166	Q0PNE2
MWAIACFATQRQCRE	AGO3	451	Q9H9G7
VWKLSSCDMCELARN	AMPD2	786	Q01433
KLERQMNCDVLWCVL	ATP10A	301	O60312
WMREKTVRCLSCKCL	ADNP2	741	Q6IQ32
QMREILSCLEFFCRW	APOLD1	161	Q96LR9
CRKCETRVLAWKIFS	FBXW10B	26	O95170
MTVRFCGKLVSFCWL	OR11H4	146	Q8NGC9
WCRMLKCNVKSFLVR	KIAA0100	1011	Q14667
ERMSIQCDVWRSKFL	BLZF1	206	Q9H2G9
QCDVWRSKFLASRVM	BLZF1	211	Q9H2G9
LCWITCTVLKRQMDK	NLRP11	341	P59045
TKRCICDPFWMENFI	KIAA0319L	901	Q8IZA0
KVYWMCRDQARLGCR	FLYWCH1	626	Q4VC44
MCQWMEKFRKDLCRF	GINM1	241	Q9NU53
ELCKLMNLWTERFCA	KIF11	721	P52732
MNLWTERFCALEEKC	KIF11	726	P52732
LKEERWCCGRNARMS	METTL25	441	Q8N6Q8
ELCKLMCERLKLSTW	ECPAS	1716	Q5VYK3
KCRWRQCLQFAMKRL	MBD1	371	Q9UIS9
LQQMLDRSCWVCFAT	MARCHF5	6	Q9NX47
LADWKKMACLLCRRQ	RBM5	641	P52756
LRSNKVMWVCNLCRK	RIMS2	156	Q9UQ26
MLQWRRRHCCFAKMT	B3GALT2	1	O43825
CVWCRMTFHRKCELS	DGKG	366	P49619
ILRCMRDCRVWSALY	FHIP1A	511	Q05DH4
RLCRFVKEQTMWACL	IFT80	606	Q9P2H3
SRRELCECMRVCKTW	KDM2A	906	Q9Y2K7
DILWKNCEFLVNRMC	CCDC150	91	Q8NCX0
WMCNKFRCGETRLEA	ENPP3	96	O14638
FFCGIAKVMEVWCRN	DCST1	291	Q5T197
AFECMVCTKVWANIR	FUT10	386	Q6P4F1
CLRQTTSPRNWCIKM	CACNA1I	61	Q9P0X4
NAWGILRCVIDICMK	EIF3D	486	O15371
ECLRAVLKLMSECWA	BMPR1A	491	P36894
KCYMRDLCVIDAQWL	DHX33	676	Q9H6R0
KMRCEFLACWPAFTV	CSAG2	31	Q9Y5P2
MQSKRDCELWCERVN	DND1	1	Q8IYX4
KRLTFWTCLAVICMV	GPR85	131	P60893
CVRWRKRFTFVCKMS	FAM102A	56	Q5T9C2
CVALPWQEELCLRFM	FAAH	551	O00519
AQITPKMCLLEWCRR	DUS2	366	Q9NX74
KMCLLEWCRREKLAQ	DUS2	371	Q9NX74
RLSRQALMRCCLVKW	KCNIP3	36	Q9Y2W7
AIRKVTCCLMVIWFS	SLC22A20P	336	A6NK97
EMLRIELAYLCTCWR	PHKA2	541	P46019
VDVWCQTERMLCFSV	NXF2	486	Q9GZY0
TRRWICHCFMAVKDT	NUMB	136	P49757
KKRLTLCWQELEAMC	FER1L6	661	Q2WGJ9
MRLFGQRCQKCSWSQ	RTP4	86	Q96DX8
MCVATRKTRTALWCA	MEIOC	891	A2RUB1
KRSFQRILCLSWMDN	SSTR1	331	P30872
QMRTSQKDVRCPWCR	RNF152	41	Q8N8N0
MLQACVGSWLDREKC	SFTPB	321	P07988
FKCVWRCYRLIKCMN	LAPTM5	206	Q13571
FLCLMCWVRSDNKRP	LIPI	6	Q6XZB0
GCCEKWELMERVTRL	RFFL	271	Q8WZ73
VWLCQRFSRALMAAK	SPAST	76	Q9UBP0
IKIALRWFCMQKCVS	RPTOR	271	Q8N122
NRWQSCEALRVMAKI	TGFBR1	456	P36897
CEALRVMAKIMRECW	TGFBR1	461	P36897
MLCDTWCIEAAARIR	ACADVL	601	P49748
CRACVDFKTWMRTQQ	GFER	71	P55789
CDNLLTCVMRAWDRS	PPCDC	116	Q96CD2
LCWSRFAQIRAELMK	PRAMEF6	426	Q5VXH4
CLQIMLDKGKLWFRC	ZNF451	741	Q9Y4E5
TLRTCWLAMADFRKT	WNT2	216	P09544
EMCRLKWLEISCSLR	UBTFL6	61	P0CB48
WRKTQCMPREVCIDV	VEGFC	126	P49767
AAGSCDKMIRVWCLR	PHIP	241	Q8WWQ0
DKMIRVWCLRTCAPL	PHIP	246	Q8WWQ0
RQKRWQCRMCEKSYT	ZNF710	291	Q8N1W2
ACYTWRRRRVCKQSM	SIGLEC1	1661	Q9BZZ2
LTRLWDRVMIEQECC	UPK1A	146	O00322
FDWCAVGCIQQLRKM	CAD	951	P27708
VTKTWDRLMLQDNCC	UPK1B	146	O75841
REFWELCNKCNLMRP	ZDHHC21	86	Q8IVQ6
IKGIQVRMKWCATCR	ZDHHC5	96	Q9C0B5
VEAERTPWNCIFCRM	SP140	721	Q13342
DKIEFNRMCWTLCVK	SWAP70	86	Q9UH65
QLQCEFCPVTRWKMA	ZRSR2P1	301	Q15695
RWKMAICGLFEIQQC	ZRSR2P1	311	Q15695
QLQCEFCPVTRWKMA	ZRSR2	296	Q15696
RWKMAICGLFEIQQC	ZRSR2	306	Q15696
ACLRCWDQRTIMKPL	TLE6	441	Q9H808
CRSALMEQRLFWKFE	JTB	96	O76095
TLDKVCNMARDCRDW	LDLR	291	P01130
LLRELCIKNMVWKYC	MYO1C	846	O00159
CSSLIWIMDRASVCK	MYO9A	2016	B2RTY4