Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentkeratin filament

KRTAP9-4 KRT85 KRTAP9-2 KRTAP9-9

9.94e-0597524GO:0045095
GeneOntologyCellularComponentFAR/SIN/STRIPAK complex

PPP2CA PPP2CB

8.06e-0417522GO:0090443
GeneOntologyCellularComponentprotein phosphatase type 2A complex

PPP2CA PPP2CB

9.05e-0418522GO:0000159
DomainBMP_1/tolloid-like

BMP1 TLL2

2.28e-053522IPR015446
DomainPecanex_C

PCNX3 PCNX1

4.55e-054522PF05041
DomainPecanex

PCNX3 PCNX1

4.55e-054522IPR007735
DomainPLPL

PNPLA1 PNPLA5

7.56e-055522IPR033562
DomainPeptidase_M12A

BMP1 TLL2

1.13e-046522IPR001506
DomainAstacin

BMP1 TLL2

1.13e-046522PF01400
DomainKeratin_B2_2

KRTAP9-4 KRTAP9-2 KRTAP9-9

1.73e-0439523PF13885
DomainKeratin_B2

KRTAP9-4 KRTAP9-2 KRTAP9-9

1.87e-0440523PF01500
DomainPatatin/PLipase_A2-rel

PNPLA1 PNPLA5

2.70e-049522IPR002641
DomainPNPLA

PNPLA1 PNPLA5

2.70e-049522PS51635
DomainPatatin

PNPLA1 PNPLA5

2.70e-049522PF01734
DomainKAP

KRTAP9-4 KRTAP9-2 KRTAP9-9

5.64e-0458523IPR002494
DomainSer/Thr-sp_prot-phosphatase

PPP2CA PPP2CB

5.82e-0413522IPR006186
DomainSER_THR_PHOSPHATASE

PPP2CA PPP2CB

5.82e-0413522PS00125
DomainPP2Ac

PPP2CA PPP2CB

5.82e-0413522SM00156
DomainAcyl_Trfase/lysoPLipase

PNPLA1 PNPLA5

1.01e-0317522IPR016035
DomainEGF_CA

BMP1 TLL2 LTBP2

1.77e-0386523PF07645
DomainEGF_Ca-bd_CS

BMP1 TLL2 LTBP2

2.50e-0397523IPR018097
DomainEGF_CA

BMP1 TLL2 LTBP2

2.64e-0399523PS01187
DomainCalcineurin-like_PHP_ApaH

PPP2CA PPP2CB

2.74e-0328522IPR004843
DomainMetallophos

PPP2CA PPP2CB

2.74e-0328522PF00149
DomainZnMc

BMP1 TLL2

2.94e-0329522SM00235
DomainPeptidase_Metallo

BMP1 TLL2

2.94e-0329522IPR006026
DomainMetallo-depent_PP-like

PPP2CA PPP2CB

3.15e-0330522IPR029052
Domain-

PPP2CA PPP2CB

3.15e-03305223.60.21.10
DomainEGF-type_Asp/Asn_hydroxyl_site

BMP1 TLL2 LTBP2

3.21e-03106523IPR000152
DomainEGF_CA

BMP1 TLL2 LTBP2

4.76e-03122523SM00179
DomainEGF-like_Ca-bd_dom

BMP1 TLL2 LTBP2

4.98e-03124523IPR001881
DomainEGF

BMP1 TLL2 LTBP2

5.21e-03126523PF00008
DomainCUB

BMP1 TLL2

8.22e-0349522PF00431
DomainCUB

BMP1 TLL2

8.55e-0350522SM00042
Domain-

BMP1 TLL2

9.22e-03525222.60.120.290
DomainCUB

BMP1 TLL2

9.57e-0353522PS01180
PathwayREACTOME_CTLA4_INHIBITORY_SIGNALING

PPP2CA PPP2CB CD80

2.93e-0521413M5876
PathwayREACTOME_CTLA4_INHIBITORY_SIGNALING

PPP2CA PPP2CB CD80

2.93e-0521413MM14996
PathwayKEGG_MEDICUS_REFERENCE_CD80_CD86_CTLA4_PP2A_SIGNALING_PATHWAY

PPP2CA PPP2CB CD80

3.38e-0522413M47919
PathwayREACTOME_PP2A_MEDIATED_DEPHOSPHORYLATION_OF_KEY_METABOLIC_FACTORS

PPP2CA PPP2CB

1.72e-047412M26992
PathwayREACTOME_MASTL_FACILITATES_MITOTIC_PROGRESSION

PPP2CA PPP2CB

3.66e-0410412M27176
PathwayREACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1

PPP2CA PPP2CB

3.66e-0410412MM14509
PathwayREACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK

PPP2CA PPP2CB FLT3 CD80

3.72e-04118414M713
PathwayREACTOME_REGULATION_OF_GLYCOLYSIS_BY_FRUCTOSE_2_6_BISPHOSPHATE_METABOLISM

PPP2CA PPP2CB

5.35e-0412412M27950
PathwayREACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1

PPP2CA PPP2CB

6.31e-0413412M1015
PathwayREACTOME_ERKS_ARE_INACTIVATED

PPP2CA PPP2CB

6.31e-0413412MM14811
PathwayWP_DOPAMINE_METABOLISM

PPP2CA PPP2CB

6.31e-0413412M39622
PathwayREACTOME_ERKS_ARE_INACTIVATED

PPP2CA PPP2CB

6.31e-0413412M8410
PathwayWP_CANCER_IMMUNOTHERAPY_BY_CTLA4_BLOCKADE

PPP2CA CD80

7.35e-0414412M39840
PathwayREACTOME_INTRACELLULAR_SIGNALING_BY_SECOND_MESSENGERS

MKRN4P PPP2CA PPP2CB CD80 ADCY7

7.77e-04252415MM15585
PathwayREACTOME_SIGNALING_BY_CTNNB1_PHOSPHO_SITE_MUTANTS

PPP2CA PPP2CB

8.46e-0415412M27407
PathwayREACTOME_ANCHORING_FIBRIL_FORMATION

BMP1 TLL2

8.46e-0415412M27161
PathwayREACTOME_COSTIMULATION_BY_THE_CD28_FAMILY

PPP2CA PPP2CB CD80

9.20e-0466413MM14990
PathwayKEGG_MEDICUS_REFERENCE_COHESIN_DISSOCIATION_IN_PROPHASE

PPP2CA PPP2CB

9.65e-0416412M47870
PathwayREACTOME_DARPP_32_EVENTS

PPP2CA PPP2CB

9.65e-0416412MM14699
PathwayREACTOME_SPRY_REGULATION_OF_FGF_SIGNALING

PPP2CA PPP2CB

9.65e-0416412MM14541
PathwayREACTOME_SPRY_REGULATION_OF_FGF_SIGNALING

PPP2CA PPP2CB

9.65e-0416412M514
PathwayREACTOME_KERATINIZATION

KRTAP9-4 KRT85 KRTAP9-2 KRTAP9-9

9.89e-04153414MM15343
PathwayREACTOME_PLATELET_SENSITIZATION_BY_LDL

PPP2CA PPP2CB

1.09e-0317412MM15096
PathwayREACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE

PPP2CA PPP2CB

1.09e-0317412M27083
PathwayREACTOME_PLATELET_SENSITIZATION_BY_LDL

PPP2CA PPP2CB

1.09e-0317412M919
PathwayREACTOME_OPIOID_SIGNALLING

PPP2CA PPP2CB ADCY7

1.14e-0371413MM14491
PathwayREACTOME_CROSSLINKING_OF_COLLAGEN_FIBRILS

BMP1 TLL2

1.23e-0318412M27164
PathwayREACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE

PPP2CA PPP2CB

1.23e-0318412MM14759
PathwayREACTOME_CROSSLINKING_OF_COLLAGEN_FIBRILS

BMP1 TLL2

1.23e-0318412MM14882
PathwayREACTOME_COSTIMULATION_BY_THE_CD28_FAMILY

PPP2CA PPP2CB CD80

1.28e-0374413M17386
PathwayKEGG_MEDICUS_REFERENCE_PP2A_AKT_SIGNALING_PATHWAY

PPP2CA PPP2CB

1.37e-0319412M47525
PathwayREACTOME_ERK_MAPK_TARGETS

PPP2CA PPP2CB

1.37e-0319412MM14780
PathwayREACTOME_G_ALPHA_I_SIGNALLING_EVENTS

PPP2CA PPP2CB CCR7 GRM2 ADCY7

1.43e-03289415MM15057
PathwayKEGG_MEDICUS_REFERENCE_CONDENSIN_LOADING

PPP2CA PPP2CB

1.52e-0320412M47876
PathwayREACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION

PPP2CA PPP2CB

1.84e-0322412M6768
PathwayREACTOME_ERK_MAPK_TARGETS

PPP2CA PPP2CB

1.84e-0322412M13408
PathwayREACTOME_INTRACELLULAR_SIGNALING_BY_SECOND_MESSENGERS

PPP2CA PPP2CB FLT3 CD80 ADCY7

2.03e-03313415M27867
PathwayREACTOME_G_ALPHA_I_SIGNALLING_EVENTS

PPP2CA PPP2CB CCR7 GRM2 ADCY7

2.06e-03314415M600
PathwayREACTOME_DARPP_32_EVENTS

PPP2CA PPP2CB

2.19e-0324412M751
PathwayREACTOME_OPIOID_SIGNALLING

PPP2CA PPP2CB ADCY7

2.25e-0390413M6467
PathwayREACTOME_SIGNALING_BY_GPCR

PPP2CA PPP2CB MC4R CCR7 GRM2 ADCY7 GPHB5

2.37e-03646417MM14962
PathwayPID_MYC_PATHWAY

PPP2CA TRRAP

2.37e-0325412M139
PathwayREACTOME_CYCLIN_A_B1_B2_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION

PPP2CA PPP2CB

2.37e-0325412MM15379
PathwayREACTOME_CYCLIN_A_B1_B2_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION

PPP2CA PPP2CB

2.37e-0325412M808
PathwayREACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION

PPP2CA PPP2CB

2.77e-0327412MM14779
PathwayREACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES

PPP2CA PPP2CB

2.97e-0328412MM15132
PathwayREACTOME_NEGATIVE_REGULATION_OF_FGFR3_SIGNALING

PPP2CA PPP2CB

3.19e-0329412M27528
PathwayREACTOME_NEGATIVE_REGULATION_OF_FGFR3_SIGNALING

PPP2CA PPP2CB

3.19e-0329412MM15253
PathwayREACTOME_KERATINIZATION

KRTAP9-4 KRT85 KRTAP9-2 KRTAP9-9

3.54e-03217414M27640
PathwayREACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE

PPP2CA PPP2CB

3.64e-0331412M27400
PathwayREACTOME_NEGATIVE_REGULATION_OF_FGFR4_SIGNALING

PPP2CA PPP2CB

3.64e-0331412M27529
PathwayREACTOME_NEGATIVE_REGULATION_OF_FGFR4_SIGNALING

PPP2CA PPP2CB

3.64e-0331412MM15254
PathwayREACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE

PPP2CA PPP2CB

3.64e-0331412MM15154
PathwayREACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES

PPP2CA PPP2CB

3.64e-0331412M15195
PathwayREACTOME_SIGNALING_BY_GPCR

PPP2CA PPP2CB MC4R CCR7 GRM2 ADCY7 GPHB5

3.77e-03702417M746
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

PPP2CA PPP2CB ADCY7

3.77e-03108413M17034
PathwayREACTOME_NEGATIVE_REGULATION_OF_FGFR1_SIGNALING

PPP2CA PPP2CB

4.12e-0333412M27526
PathwayREACTOME_NEGATIVE_REGULATION_OF_FGFR2_SIGNALING

PPP2CA PPP2CB

4.12e-0333412MM15252
PathwayKEGG_OOCYTE_MEIOSIS

PPP2CA PPP2CB ADCY7

4.28e-03113413M16817
PathwayREACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK

PPP2CA PPP2CB CD80

4.28e-03113413MM14783
PathwayREACTOME_SIGNALING_BY_WNT_IN_CANCER

PPP2CA PPP2CB

4.37e-0334412M27405
PathwayREACTOME_NEGATIVE_REGULATION_OF_FGFR2_SIGNALING

PPP2CA PPP2CB

4.37e-0334412M27527
PathwayREACTOME_RAF_ACTIVATION

PPP2CA PPP2CB

4.37e-0334412M27556
PathwayWP_GLYCOGEN_METABOLISM

PPP2CA PPP2CB

4.37e-0334412MM15985
PathwayWP_COHESIN_COMPLEX_CORNELIA_DE_LANGE_SYNDROME

PPP2CA PPP2CB

4.37e-0334412M42555
PathwayREACTOME_RAF_ACTIVATION

PPP2CA PPP2CB

4.62e-0335412MM15271
PathwayREACTOME_REGULATION_OF_TP53_DEGRADATION

PPP2CA PPP2CB

4.88e-0336412MM15339
PathwayREACTOME_SIGNALING_BY_WNT

PPP2CA PPP2CB PRICKLE1 TRRAP

4.99e-03239414MM14756
PathwayREACTOME_REGULATION_OF_TP53_EXPRESSION_AND_DEGRADATION

PPP2CA PPP2CB

5.15e-0337412M27641
Pubmed

An ultra-high sulfur keratin gene is expressed specifically during hair growth.

KRTAP9-4 KRTAP9-2 KRTAP9-9

1.97e-0785432465353
Pubmed

Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes.

PPP2CA PPP2CB

2.37e-0625422837763
Pubmed

Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes.

PPP2CA PPP2CB

2.37e-0625421846293
Pubmed

Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A.

PPP2CA PPP2CB

2.37e-0625422555176
Pubmed

PP2A regulates kinetochore-microtubule attachment during meiosis I in oocyte.

PPP2CA PPP2CB

2.37e-06254227096707
Pubmed

The role of protein phosphatase 2A catalytic subunit Calpha in embryogenesis: evidence from sequence analysis and localization studies.

PPP2CA PPP2CB

2.37e-06254210543450
Pubmed

Regulation of spindle formation by active mitogen-activated protein kinase and protein phosphatase 2A during mouse oocyte meiosis.

PPP2CA PPP2CB

2.37e-06254211751260
Pubmed

Regional expression of protein phosphatase type 1 and 2A catalytic subunit isoforms in the human heart.

PPP2CA PPP2CB

2.37e-06254211113010
Pubmed

Protein phosphatase 2A in the healthy and failing heart: New insights and therapeutic opportunities.

PPP2CA PPP2CB

2.37e-06254234902541
Pubmed

Maturation and cytokine production potential of dendritic cells isolated from rheumatoid arthritis patients peripheral blood and induced in vitro.

CD80 CCR7

7.09e-06354227421624
Pubmed

Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts.

PPP2CA PPP2CB

7.09e-0635427510677
Pubmed

Genetic analysis of the role of proteolysis in the activation of latent myostatin.

BMP1 TLL2

7.09e-06354218286185
Pubmed

Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases.

BMP1 TLL2

7.09e-06354218824173
Pubmed

The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo.

PPP2CA PPP2CB

7.09e-0635428206937
Pubmed

Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2.

PPP2CA PPP2CB

7.09e-06354210441131
Pubmed

Protein phosphatase 2A dephosphorylates CaBP4 and regulates CaBP4 function.

PPP2CA PPP2CB

7.09e-06354223341017
Pubmed

Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectively.

PPP2CA PPP2CB

7.09e-0635428383590
Pubmed

Overlapping binding sites in protein phosphatase 2A for association with regulatory A and alpha-4 (mTap42) subunits.

PPP2CA PPP2CB

7.09e-06354215252037
Pubmed

Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium.

KRTAP9-4 KRTAP9-2 KRTAP9-9

8.97e-062654315454262
Pubmed

Generation of Ppp2Ca and Ppp2Cb conditional null alleles in mouse.

PPP2CA PPP2CB

1.42e-05454221998041
Pubmed

Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha.

PPP2CA PPP2CB

1.42e-0545429770493
Pubmed

Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain.

PPP2CA PPP2CB

1.42e-0545427616230
Pubmed

Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain.

PPP2CA PPP2CB

1.42e-0545429920888
Pubmed

Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4.

PPP2CA PPP2CB

1.42e-05454211371618
Pubmed

The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation.

PPP2CA PPP2CB

1.42e-05454221454489
Pubmed

Migratory properties of pulmonary dendritic cells are determined by their developmental lineage.

FLT3 CCR7

1.42e-05454223168837
Pubmed

The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein traffic.

PPP2CA PPP2CB

1.42e-05454214633983
Pubmed

Genetic variance in the adiponutrin gene family and childhood obesity.

PNPLA1 PNPLA5

2.36e-05554219390624
Pubmed

HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint.

PPP2CA PPP2CB

2.36e-0555429009195
Pubmed

Protein phosphatase 2A interacts with and directly dephosphorylates RelA.

PPP2CA PPP2CB

2.36e-05554211591705
Pubmed

Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain.

PPP2CA PPP2CB

2.36e-05554210640627
Pubmed

Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis.

BMP1 TLL2

2.36e-05554210479448
Pubmed

Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice.

PPP2CA PPP2CB

2.36e-05554218596935
Pubmed

Inflammation induces two types of inflammatory dendritic cells in inflamed lymph nodes.

FLT3 CCR7

2.36e-05554229546878
Pubmed

Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21.

KRTAP9-4 KRTAP9-2 KRTAP9-9

2.65e-053754311279113
Pubmed

Distinct role of protein phosphatase 2A subunit Calpha in the regulation of E-cadherin and beta-catenin during development.

PPP2CA PPP2CB

3.54e-05654210781942
Pubmed

Natural mannosylation of HIV-1 gp120 imposes no immunoregulatory effects in primary human plasmacytoid dendritic cells.

CD80 CCR7

3.54e-05654224632372
Pubmed

Endotoxin conditioning induces VCP/p97-mediated and inducible nitric-oxide synthase-dependent Tyr284 nitration in protein phosphatase 2A.

PPP2CA PPP2CB

3.54e-05654220100830
Pubmed

Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis.

PPP2CA PPP2CB

3.54e-05654229735529
Pubmed

Alpha 4 associates with protein phosphatases 2A, 4, and 6.

PPP2CA PPP2CB

3.54e-0565429647778
Pubmed

Protein phosphorylation of human brain glutamic acid decarboxylase (GAD)65 and GAD67 and its physiological implications.

PPP2CA PPP2CB

3.54e-05654215147202
Pubmed

STRIPAK components determine mode of cancer cell migration and metastasis.

PPP2CA PPP2CB

3.54e-05654225531779
Pubmed

Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis.

PPP2CA PPP2CB TRRAP

3.89e-054254329028833
Pubmed

GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin.

PPP2CA PPP2CB

4.94e-05754210698523
Pubmed

Protein phosphatase 2A and separase form a complex regulated by separase autocleavage.

PPP2CA PPP2CB

4.94e-05754217604273
Pubmed

The ubiquitin E3 ligase NOSIP modulates protein phosphatase 2A activity in craniofacial development.

PPP2CA PPP2CB

4.94e-05754225546391
Pubmed

X-linked microtubule-associated protein, Mid1, regulates axon development.

PPP2CA PPP2CB

4.94e-05754224194544
Pubmed

p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected].

PPP2CA PPP2CB

6.59e-0585421330687
Pubmed

Type 2A protein phosphatase, the complex regulator of numerous signaling pathways.

PPP2CA PPP2CB

6.59e-05854211007961
Pubmed

Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A.

PPP2CA PPP2CB

6.59e-05854212912990
Pubmed

Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation.

PPP2CA PPP2CB

6.59e-05854216262633
Pubmed

Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy.

PPP2CA PPP2CB

6.59e-05854235768646
Pubmed

Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution.

PPP2CA PPP2CB

6.59e-05854212370081
Pubmed

Akt and PP2A reciprocally regulate the guanine nucleotide exchange factor Dock6 to control axon growth of sensory neurons.

PPP2CA PPP2CB

6.59e-05854223462102
Pubmed

Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye.

PPP2CA PPP2CB

8.46e-05954218432318
Pubmed

Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital.

PPP2CA PPP2CB

8.46e-05954212885400
Pubmed

Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions.

PNPLA1 PNPLA5

8.46e-05954219029121
Pubmed

Dendritic Cells Coordinate the Development and Homeostasis of Organ-Specific Regulatory T Cells.

CD80 CCR7

8.46e-05954227037189
Pubmed

Characterization of the human patatin-like phospholipase family.

PNPLA1 PNPLA5

1.06e-041054216799181
Pubmed

Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins.

PPP2CA LDB3

1.29e-041154211842093
Pubmed

MARF1 regulates essential oogenic processes in mice.

PPP2CA PPP2CB

1.29e-041154222442484
Pubmed

Two immunologically distinct human DNA polymerase alpha-primase subpopulations are involved in cellular DNA replication.

PPP2CA PPP2CB

1.55e-041254211259605
Pubmed

Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas.

FLT3 CCR7

1.55e-041254221029863
Pubmed

PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation.

PPP2CA PPP2CB

1.55e-041254234079065
Pubmed

Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5.

PPP2CA PPP2CB

1.55e-041254212435421
Pubmed

Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair.

KRTAP9-4 KRTAP9-2 KRTAP9-9

1.72e-046954318721477
Pubmed

Bromodomain protein Brd4 regulates human immunodeficiency virus transcription through phosphorylation of CDK9 at threonine 29.

PPP2CA PPP2CB

1.83e-041354218971272
Pubmed

PP2A1 binding, cell transducing and apoptotic properties of Vpr(77-92): a new functional domain of HIV-1 Vpr proteins.

PPP2CA PPP2CB

1.83e-041354221072166
Pubmed

PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum.

PPP2CA PPP2CB

1.83e-041354216717086
Pubmed

Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr.

PPP2CA PPP2CB

2.13e-04145429013886
Pubmed

Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production.

PPP2CA PPP2CB

2.13e-04145429400615
Pubmed

The non-canonical Wnt-PCP pathway shapes the mouse caudal neural plate.

PRICKLE1 GPC4

2.45e-041554229636380
Pubmed

Deletion of Sarcolemmal Membrane-Associated Protein Isoform 3 (SLMAP3) in Cardiac Progenitors Delays Embryonic Growth of Myocardium without Affecting Hippo Pathway.

PPP2CA PPP2CB

2.45e-041554238474134
Pubmed

Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression.

FLT3 CCR7

2.80e-041654232895539
Pubmed

Interferon-induced SCYL2 limits release of HIV-1 by triggering PP2A-mediated dephosphorylation of the viral protein Vpu.

PPP2CA PPP2CB

2.80e-041654223047923
Pubmed

Regulation of HIV-1 transcription by protein phosphatase 1.

PPP2CA PPP2CB

3.17e-041754217266553
Pubmed

[Action of protein phosphatase-1 on Tat-dependent HIV-1 transcription and its related inhibitors].

PPP2CA PPP2CB

3.17e-041754221351466
Pubmed

Molecular mechanisms involved in HIV-1-Tat mediated inhibition of telomerase activity in human CD4(+) T lymphocytes.

PPP2CA PPP2CB

3.56e-041854223287597
Pubmed

A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity.

PPP2CA PPP2CB

3.56e-041854216085932
Pubmed

Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55α, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development.

PPP2CA PPP2CB

3.98e-041954232582689
Pubmed

Liganded ERα Stimulates the E3 Ubiquitin Ligase Activity of UBE3C to Facilitate Cell Proliferation.

PPP2CA PPP2CB

3.98e-041954226389696
Pubmed

Shugoshin collaborates with protein phosphatase 2A to protect cohesin.

PPP2CA PPP2CB

3.98e-041954216541025
Pubmed

Protein phosphatase 2A catalytic subunit α (PP2Acα) maintains survival of committed erythroid cells in fetal liver erythropoiesis through the STAT5 pathway.

PPP2CA PPP2CB

4.42e-042054221514445
Pubmed

Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy.

PPP2CA PPP2CB

5.86e-042354226644582
Pubmed

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.

BMP1 GPC4 LTBP2 ADAMTSL4

6.03e-0424854424006456
Pubmed

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer.

PPP2CA PPP2CB

6.94e-042554234004147
Pubmed

The DNA sequence and analysis of human chromosome 14.

PCNX1 LTBP2 GPHB5

6.97e-0411154312508121
Pubmed

HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25.

PPP2CA PPP2CB

7.51e-042654211531413
Pubmed

Genetic variations in humans associated with differences in the course of hepatitis C.

CD80 LTBP2

1.14e-033254215063762
Pubmed

Secreted protein acidic and rich in cysteine (SPARC) gene polymorphism association with hepatocellular carcinoma in Italian patients.

CD80 LTBP2

1.21e-033354219817957
Pubmed

RUNX1 and TGF-β signaling cross talk regulates Ca2+ ion channels expression and activity during megakaryocyte development.

BMP1 LTBP2

1.36e-033554232281291
Pubmed

Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development.

PPP2CA PPP2CB

1.44e-033654222422068
Pubmed

Control of APC/C-dependent ubiquitin chain elongation by reversible phosphorylation.

PPP2CA PPP2CB

1.52e-033754226811472
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PPP2CB DIP2A PCNX3 PCNX1 PIGG TRRAP ADCY7

1.54e-03110554735748872
InteractionTFAP2D interactions

KRTAP9-2 KPRP TRRAP ADAMTSL4 ZMYND12

3.31e-0689525int:TFAP2D
InteractionGNE interactions

TRIM67 KRT85 KRTAP9-2 KPRP ADAMTSL4

7.12e-06104525int:GNE
InteractionLCE3E interactions

KRTAP9-4 KRTAP9-2 KPRP ADAMTSL4

1.73e-0560524int:LCE3E
InteractionLCE3C interactions

KRTAP9-4 KRTAP9-2 KPRP ADAMTSL4

2.68e-0567524int:LCE3C
InteractionNTN4 interactions

FLT3 KPRP ADAMTSL4

2.77e-0523523int:NTN4
InteractionCDC20 interactions

PPP2CA PPP2CB TRIM67 KRT85 KRTAP9-2 TRRAP

2.99e-05234526int:CDC20
InteractionNR4A3 interactions

KRTAP9-2 KPRP TRRAP ADAMTSL4

3.01e-0569524int:NR4A3
InteractionMAPKBP1 interactions

KRTAP9-4 KRTAP9-2 KPRP ADAMTSL4

3.97e-0574524int:MAPKBP1
InteractionOTX1 interactions

KRTAP9-4 KRT85 KRTAP9-2 KPRP ADAMTSL4

4.90e-05155525int:OTX1
InteractionRGL2 interactions

TRIM67 KPRP ADAMTSL4

5.07e-0528523int:RGL2
InteractionCREB5 interactions

KRTAP9-4 KRT85 KRTAP9-2 KPRP ADAMTSL4

6.41e-05164525int:CREB5
InteractionLCMT1 interactions

PPP2CA PPP2CB TRIM67

8.37e-0533523int:LCMT1
InteractionKRTAP9-4 interactions

KRTAP9-4 KRTAP9-2 ADAMTSL4

8.37e-0533523int:KRTAP9-4
InteractionNIF3L1 interactions

PPP2CA PPP2CB TRIM67 PNPLA1 TRRAP

8.71e-05175525int:NIF3L1
InteractionNUFIP2 interactions

TRIM67 KRTAP9-4 KRTAP9-2 KPRP LTBP2 ADAMTSL4 NBR1

9.25e-05417527int:NUFIP2
CytobandEnsembl 112 genes in cytogenetic band chr17q21

KRTAP9-4 KRTAP9-2 KRTAP9-9 CCR7 NBR1

2.37e-04473545chr17q21
Cytoband17q12-q21

KRTAP9-4 KRTAP9-2

6.58e-043254217q12-q21
GeneFamilyBone morphogenetic proteins|Astacins

BMP1 TLL2

7.48e-056412894
GeneFamilyPatatin like phospholipase domain containing

PNPLA1 PNPLA5

2.23e-0410412466
GeneFamilyProtein phosphatase catalytic subunits|EF-hand domain containing

PPP2CA PPP2CB

3.85e-0413412693
GeneFamilyProtein phosphatase catalytic subunits|STRIPAK complex

PPP2CA PPP2CB

9.29e-04204121371
GeneFamilyKeratin associated proteins

KRTAP9-4 KRTAP9-2 KRTAP9-9

1.92e-03109413619
GeneFamilyOlfactory receptors, family 52

OR52E1 OR52Z1P

5.52e-0349412165
GeneFamilyLIM domain containing

LDB3 PRICKLE1

7.91e-03594121218
GeneFamilyRing finger proteins

MKRN4P TRIM67 RNF180

2.43e-0227541358
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_F_UP

LDB3 PRICKLE1 GPC4 PCNX1 LTBP2 ADAMTSL4

1.72e-06184526M8544
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_F_UP

LDB3 PRICKLE1 GPC4 PCNX1 LTBP2 ADAMTSL4

1.95e-06188526MM983
CoexpressionNABA_MATRISOME_METASTATIC_COLORECTAL_LIVER_METASTASIS

BMP1 GPC4 LTBP2

2.88e-0530523M47990
CoexpressionGSE34156_TLR1_TLR2_LIGAND_VS_NOD2_AND_TLR1_TLR2_LIGAND_6H_TREATED_MONOCYTE_UP

LRRC8C PPP2CA PIGG GRM2 NBR1

4.78e-05200525M8693
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Papillary_Muscle_Invasive_Urothelial_Carcinoma-10|TCGA-Bladder / Sample_Type by Project: Shred V9

KRTAP9-4 KRT85 KRTAP9-9 GPHB5

1.69e-051295346a201c6344a015e5cf2f79ccf397fd7ad66b6768
ToppCellLPS-IL1RA+antiTNF-Myeloid-Dendritic_cells-mDC|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLT3 CD80 CCR7 ADCY7

1.85e-05132534f8e2ba53063007d7507f1837ad669b0e4333cd23
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-6|TCGA-Skin / Sample_Type by Project: Shred V9

KRTAP9-4 KRT85 KRTAP9-9 PNPLA5

2.75e-05146534522c32103c24fc26836bb5b642083904682d9292
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-Lgr5-_amplifying_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT3 CCR7 PNPLA5 ADCY7

3.48e-05155534f3489a548a2c0cc2d9117ff85865c6089ea0835d
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-epithelial_cell_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT3 CCR7 PNPLA5 ADCY7

3.48e-051555340e24e767a3895d31d34cabeaca0354aadae34e44
ToppCellPND10-Immune-Immune_Myeloid-DC-maDC-maDC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FLT3 CD80 CCR7 RNF180

4.87e-05169534a83e4078db91ecedee637b28b12ec38640fe45f9
ToppCellPND10-Immune-Immune_Myeloid-DC-maDC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FLT3 CD80 CCR7 RNF180

4.87e-05169534f914aa8899fa170a09da31e5fad86de897ea789b
ToppCellcontrol-Myeloid-Monocyte-derived_Macrophage|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

LRRC8C FLT3 CD80 CCR7

5.10e-05171534e828b684744a4fdf6b63ec033c4f000b39ca0d51
ToppCellfacs-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLT3 KRT85 CCR7 RNF180

5.22e-0517253448d0cfc37d1b1ae48ed8f8b2711abeb609d2bb6e
ToppCellfacs-Lung-EPCAM-18m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT3 KRT85 CCR7 RNF180

5.22e-051725347c085c02b59e24e2a2cd393b5e692f9fb19257fe
ToppCellfacs-Lung-EPCAM-18m-Myeloid-Ccr7+_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT3 KRT85 CCR7 RNF180

5.22e-05172534c5caae0b21e35a2d5dcd898fbfa1ef33f92c019f
ToppCellNS-control-d_0-4-Myeloid-Monocyte-derived_Macrophage|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

LRRC8C FLT3 CD80 CCR7

5.46e-05174534758984730cd1c3ccf6866a3a8f03d6e002f3edb6
ToppCellLPS-IL1RA-Myeloid-Dendritic_cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLT3 CD80 CCR7 ADCY7

5.71e-05176534f3bbe8c1a8d132705eac360cf531261271d84588
ToppCellCOVID-19-APC-like-Dendritic_cells|COVID-19 / group, cell type (main and fine annotations)

FLT3 CD80 CCR7 ADCY7

6.64e-05183534703364836b42aa6ac6c68b42b700ac23c4a1afc7
ToppCellCOVID-19-APC-like|COVID-19 / group, cell type (main and fine annotations)

FLT3 CD80 CCR7 ADCY7

6.64e-05183534b8f5afaf9ff1b2b1bc60be58654d1b23859dafa9
ToppCelldroplet-Lung-18m-Mesenchymal-myofibroblast|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LDB3 TRIM67 GPC4 LTBP2

7.99e-051925342cc712186e37fb21a964c032765c36a8b4a852cf
ToppCellLPS_only-Hematopoietic_Myeloid-Dendritic_cells-mDC|LPS_only / Treatment groups by lineage, cell group, cell type

FLT3 CD80 CCR7 EFCAB14

9.00e-0519853453c22e81e530d6fc272d4a45c8d1bf125feb254d
ToppCellLPS_IL1RA_TNF-Hematopoietic_Myeloid-Dendritic_cells|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FLT3 CD80 CCR7 ADCY7

9.00e-05198534436f3a9ef31b0991765bb97c21960f20fa71d578
ToppCellLPS_IL1RA-Hematopoietic_Myeloid-Dendritic_cells|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

FLT3 CD80 CCR7 ADCY7

9.00e-05198534ba3b97bb3e1533df758e845bde7d82eb1525b057
ToppCellLPS_IL1RA_TNF-Hematopoietic_Myeloid-Dendritic_cells-mDC|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FLT3 CD80 CCR7 ADCY7

9.36e-05200534f78968d4b4d907094b2c44dcf5ac557ae94e4484
DiseaseChanarin-Dorfman syndrome (implicated_via_orthology)

PNPLA1 PNPLA5

3.87e-056482DOID:0050729 (implicated_via_orthology)
DiseaseAnhedonia

MC4R CCR7

6.99e-0424482C0178417

Protein segments in the cluster

PeptideGeneStartEntry
CIYVPCQCFAVGFLK

PNAS-138

31

Q9BZS9
ARLCVYPYYTATCCR

ADAMTSL4

1046

Q6UY14
CYILLGGVFLCYCMT

GRM2

606

Q14416
CVRCCVNPFLYAFIG

CCR7

316

P32248
CYNCISDCPNLRVYF

CRYGA

16

P11844
CEPLPYYTCSCVLGF

ADCY7

716

P51828
GIFVICCLTYCFAPR

CD80

256

P33681
IVFTYRPCGCCSYVG

BMP1

176

P13497
ICYPLCGFVILAACV

EFCAB14

71

O75071
CGVVCKYFQRGCCVY

MKRN4P

121

Q13434
CCPFIFLVYRLTYCG

OR52Z1P

141

P0C646
FCIQLPLICGTYYFT

MSMO1

106

Q15800
CYVAICDPLCYTLVL

OR52E1

121

Q8NGJ3
LYCGPCHIAYFFCDI

OR10S1

181

Q8NGN2
VYCERCYEQFFAPLC

LDB3

596

O75112
RCCISAAPYRGVSCY

KRT85

31

P78386
HCRGLVTVKPCYNYC

GPC4

256

O75487
IIAYSRPVYFCICCG

PCNX1

1066

Q96RV3
YSRPVYFCICCLLIW

PCNX3

856

Q9H6A9
EALYCSCFVPVYCGL

PNPLA1

146

Q8N8W4
VVTIFSAPNYCYRCG

PPP2CB

256

P62714
VVTIFSAPNYCYRCG

PPP2CA

256

P67775
RPFCCGCFESLYAEY

PRICKLE1

236

Q96MT3
CTLSGPIYLIFEYCC

FLT3

681

P36888
FYTYPVAIRCDCGAC

GPHB5

106

Q86YW7
PVGVVCYRVYCCCCL

DENND11

266

A4D1U4
RCINRVGSYSCFCYP

LTBP2

901

Q14767
IFYISCPQNPYCVCF

MC4R

266

P32245
VLYCGVCSLPTEYCE

DENR

31

O43583
CFVECAPVCYTETCY

KPRP

131

Q5T749
CAPVYCRRTCYYPTT

KRTAP9-2

111

Q9BYQ4
CAPVYCRRTCYYPTT

KRTAP9-4

96

Q9BYQ2
CAPVYCRRTCYYPTT

KRTAP9-9

91

Q9BYP9
IAAFYGCLYCGCVPV

DIP2A

1056

Q14689
CQVTGCQCRAYLYVP

FAM221A

101

A4D161
RASFVTCPCCYGFIQ

GSTCD

531

Q8NEC7
VFQVCIGCFLCYCPG

ATP4A

971

P20648
ICAVCLDVYFNPYMC

RNF180

431

Q86T96
GVRYQCSLCPSYNIC

NBR1

226

Q14596
IQALVCTLYFPFYCG

PNPLA5

141

Q7Z6Z6
CFPCVGYSVPFCYVN

WDR17

1021

Q8IZU2
YSMYCVSCRTPVCYL

TRIM67

311

Q6ZTA4
GYIYPRLYCLFAECC

TOR1A

36

O14656
LCGYVYALRVERFCC

SLFN12L

316

Q6IEE8
VFSYRTCGCCSYVGR

TLL2

206

Q9Y6L7
VFLYTLGCVCAACLY

UBIAD1

136

Q9Y5Z9
LGCVCAACLYYLSPL

UBIAD1

141

Q9Y5Z9
PSVLVGYFCCYCHFS

TAMM41

436

Q96BW9
RVCAACTVTYYCGVV

ZMYND12

26

Q9H0C1
LIICCLCGSGYLIYF

TMC2

436

Q8TDI7
FCYALICSIPVFTYI

PIGG

921

Q5H8A4
LEIPTGPRCYSCYVC

ZNF425

181

Q6IV72
GPRCYSCYVCRKVFQ

ZNF425

186

Q6IV72
RECFTGYRQLCGCYL

TMLHE

391

Q9NVH6
PLFSYIVERLCACCY

TRRAP

1136

Q9Y4A5
ICFTTCCVYRPLKFR

TRPV5

341

Q9NQA5
FCYLCFVSIYGLTCL

LRRC8C

321

Q8TDW0