Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent activity	MYH9 EP400 CCT5 WRN NAV1 TCIRG1 ABCC5 DHX29	1.31e-04	614	50	8	GO:0140657
Domain	DEAH_ATP_HELICASE	EP400 WRN DHX29	1.34e-04	38	49	3	PS00690
Domain	Myosin_tail_1	MYH9 CGN	1.00e-03	18	49	2	PF01576
Domain	Myosin_tail	MYH9 CGN	1.00e-03	18	49	2	IPR002928
Domain	Helicase_C	EP400 WRN DHX29	2.78e-03	107	49	3	PF00271
Domain	HELICc	EP400 WRN DHX29	2.78e-03	107	49	3	SM00490
Domain	Helicase_C	EP400 WRN DHX29	2.86e-03	108	49	3	IPR001650
Domain	HELICASE_CTER	EP400 WRN DHX29	2.93e-03	109	49	3	PS51194
Domain	HELICASE_ATP_BIND_1	EP400 WRN DHX29	2.93e-03	109	49	3	PS51192
Domain	DEXDc	EP400 WRN DHX29	2.93e-03	109	49	3	SM00487
Domain	Helicase_ATP-bd	EP400 WRN DHX29	3.01e-03	110	49	3	IPR014001
Domain	DNA/RNA_helicase_DEAH_CS	EP400 DHX29	3.80e-03	35	49	2	IPR002464
Domain	SET	NSD2 SMYD1	5.18e-03	41	49	2	PF00856
Domain	P-loop_NTPase	MYH9 EP400 WRN NAV1 ABCC5 DHX29 HYDIN	6.31e-03	848	49	7	IPR027417
Domain	SET	NSD2 SMYD1	6.48e-03	46	49	2	SM00317
Domain	-	WRN ERI2	6.76e-03	47	49	2	3.30.420.10
Domain	SET_dom	NSD2 SMYD1	7.62e-03	50	49	2	IPR001214
Domain	SET	NSD2 SMYD1	7.62e-03	50	49	2	PS50280
Pubmed	Fyn Regulates Binding Partners of Cyclic-AMP Dependent Protein Kinase A.	MYH9 CAND1 CSE1L CCT5	6.59e-06	82	51	4	30274258
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	CRACD MYH9 CAND1 EP400 MAP1B RNF113A SEC23IP CAST DHX29	7.73e-06	934	51	9	33916271
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	MYH9 CSE1L MAP1B CCT5 SEC23IP ABCC5 DHX29 CDKAL1	8.34e-06	708	51	8	39231216
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CRACD MED19 CAND1 EP400 CCT5 NSD2 WRN SREK1 SUZ12 DHX29 FHIP1A	8.81e-06	1497	51	11	31527615
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	KDM3A CRACD MYH9 EP400 CCT5 RNF113A PFDN5	8.81e-06	506	51	7	30890647
Pubmed	In vitro nuclear interactome of the HIV-1 Tat protein.	MYH9 CAND1 EP400 NSD2 SUZ12	1.00e-05	195	51	5	19454010
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KDM3A CAND1 EP400 CCT5 NSD2 FBRSL1 ERI2	1.17e-05	529	51	7	14621295
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	KDM3A EP400 MAP1B CCT5 CGN SEC23IP CAST	1.49e-05	549	51	7	38280479
Pubmed	BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.	CAND1 MAP1B CCT5 MRPL19 PFDN5	2.04e-05	226	51	5	25900982
Pubmed	Identification of FBXO25-interacting proteins using an integrated proteomics approach.	MYH9 CAND1 CSE1L CCT5	2.27e-05	112	51	4	20473970
Pubmed	Quantitative interactome proteomics identifies a proteostasis network for GABAA receptors.	MYH9 CAND1 CSE1L CCT5	3.49e-05	125	51	4	36030824
Pubmed	Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.	MYH9 CAND1 CSE1L MAP1B CCT5	3.84e-05	258	51	5	21081666
Pubmed	Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.	MYH9 CAND1 CSE1L CCT5 SEC23IP CDKAL1	4.93e-05	449	51	6	31732153
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	CAND1 CSE1L EP400 SUZ12 ARMCX2 HYDIN	6.28e-05	469	51	6	27634302
Pubmed	A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair.	MYH9 CAND1 CSE1L CCT5	7.66e-05	153	51	4	27462432
Pubmed	Analysis of Ku70 S155 Phospho-Specific BioID2 Interactome Identifies Ku Association with TRIP12 in Response to DNA Damage.	CAND1 MAP1B CCT5 NSD2	8.26e-05	156	51	4	37108203
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	CFAP47 MYH9 CAND1 CSE1L CCT5 SEC23IP	8.35e-05	494	51	6	26831064
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	MYH9 CAND1 CCT5 FBRSL1 PFDN5 SUZ12	8.44e-05	495	51	6	27705803
Pubmed	The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.	MYH9 CAND1 CSE1L MAP1B CCT5	1.06e-04	320	51	5	28685749
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	MYH9 MED19 CAND1 CSE1L EP400 CCT5 NSD2 SUZ12	1.06e-04	1014	51	8	32416067
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	CAND1 CSE1L MAP1B NSD2 WRN SUZ12 DHX29	1.15e-04	759	51	7	35915203
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	MYH9 CAND1 EP400 CCT5 SEC23IP WRN ABCC5	1.33e-04	777	51	7	35844135
Pubmed	Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.	CRACD MYH9 MAP1B	1.33e-04	67	51	3	29254152
Pubmed	Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.	EP400 SEC23IP SREK1 SFMBT2	1.34e-04	177	51	4	26206133
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	MYH9 CAND1 CSE1L EP400 MAP1B NSD2 MRPL19 SREK1	1.66e-04	1082	51	8	38697112
Pubmed	BGL3 lncRNA mediates retention of the BRCA1/BARD1 complex at DNA damage sites.	MYH9 CSE1L CCT5	1.72e-04	73	51	3	32347575
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	MYH9 CAND1 CSE1L CCT5 NSD2 SEC23IP SREK1 SUZ12 DHX29	2.04e-04	1425	51	9	30948266
Pubmed	The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis.	CCT5 PFDN5	2.19e-04	15	51	2	30955883
Pubmed	Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.	MYH9 CSE1L MAP1B CCT5	3.03e-04	219	51	4	31353912
Pubmed	The prefoldin complex stabilizes the von Hippel-Lindau protein against aggregation and degradation.	CCT5 PFDN5	3.18e-04	18	51	2	33137104
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CRACD SEMA6D EP400 NAV1 SUZ12	3.23e-04	407	51	5	12693553
Pubmed	Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry.	MYH9 CAND1 CCT5 PFDN5 SUZ12	3.38e-04	411	51	5	36652389
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	MED19 EP400 MAP1B NSD2 NAV1 SUZ12	3.52e-04	645	51	6	25281560
Pubmed	Gene essentiality and synthetic lethality in haploid human cells.	TRAPPC13 CCT5 SEC23IP PFDN5	3.59e-04	229	51	4	26472760
Pubmed	A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.	CSE1L EP400 CCT5 WRN PFDN5	3.69e-04	419	51	5	28700943
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MYH9 CSE1L MAP1B CCT5 NSD2 CGN	3.76e-04	653	51	6	22586326
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	MAP1B SBF2 NAV1 SUZ12	3.77e-04	232	51	4	25515538
Pubmed	PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.	ADAM30 CDKAL1	3.94e-04	20	51	2	19862325
Pubmed	USP45 and Spindly are part of the same complex implicated in cell migration.	CRACD MYH9 CAND1 CSE1L	3.96e-04	235	51	4	30258100
Pubmed	Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.	ADAM30 CDKAL1	4.35e-04	21	51	2	18591388
Pubmed	A novel functional role for MMSET in RNA processing based on the link between the REIIBP isoform and its interaction with the SMN complex.	MAP1B NSD2	4.35e-04	21	51	2	24923560
Pubmed	Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SEMA6D EP400 ERI2	4.74e-04	103	51	3	10819331
Pubmed	Co-adaptor driven assembly of a CUL3 E3 ligase complex.	CAND1 SEC23IP	4.78e-04	22	51	2	35120648
Pubmed	Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.	ADAM30 CDKAL1	4.78e-04	22	51	2	18372903
Pubmed	Profiling the interactome of protein kinase C ζ by proteomics and bioinformatics.	MAP1B CCT5 MRPL19	5.01e-04	105	51	3	29491746
Pubmed	An integrated workflow for charting the human interaction proteome: insights into the PP2A system.	MYH9 CCT5 PFDN5	5.01e-04	105	51	3	19156129
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	MYH9 CAND1 CSE1L CCT5 SEC23IP	5.16e-04	451	51	5	36168627
Pubmed	CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism.	EP400 SUZ12	5.23e-04	23	51	2	31281901
Pubmed	Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	EP400 HYDIN CCDC136	5.30e-04	107	51	3	11347906
Pubmed	Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants.	MYH9 CAND1 MAP1B CCT5	5.46e-04	256	51	4	35777956
Pubmed	Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.	MYH9 CSE1L MAP1B CCT5	5.46e-04	256	51	4	32698014
Pubmed	Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events.	BEX5 ARMCX2	5.70e-04	24	51	2	16221301
Pubmed	The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4.	MYH9 MAP1B CCT5	5.74e-04	110	51	3	18307411
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	MYH9 MED19 CAND1 EP400 CCT5 WRN SREK1 CDKAL1	6.22e-04	1318	51	8	30463901
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	KDM3A MYH9 CAND1 CSE1L MAP1B WRN PFDN5	6.30e-04	1005	51	7	19615732
Pubmed	Insights into the ubiquitin-proteasome system of human embryonic stem cells.	MED19 CSE1L SEC23IP SREK1	6.57e-04	269	51	4	29511261
Pubmed	Characterization of carbonic anhydrase IX interactome reveals proteins assisting its nuclear localization in hypoxic cells.	CAND1 CSE1L	6.70e-04	26	51	2	23181366
Pubmed	Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.	CRACD MYH9 MAP1B	6.70e-04	116	51	3	30652415
Pubmed	Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation.	MYH9 CAND1 CSE1L CCT5	6.76e-04	271	51	4	26816005
Pubmed	C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways.	CAND1 CSE1L CCT5	7.22e-04	119	51	3	35776542
Pubmed	Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.	TRAPPC13 CAND1 SEC23IP BCAT2	7.23e-04	276	51	4	28319085
Pubmed	Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.	MYH9 CAND1 CSE1L MAP1B CCT5	7.84e-04	495	51	5	28581483
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	CRACD MYH9 MAP1B NAV1 DHX29	8.06e-04	498	51	5	36634849
Pubmed	Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture.	CAND1 SEC23IP	9.54e-04	31	51	2	22261722
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	EP400 MAP1B CCT5 SREK1	9.86e-04	300	51	4	28561026
Pubmed	Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition.	PFDN5 SUZ12	1.02e-03	32	51	2	21460039
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	CRACD MYH9 CAND1 CSE1L MAP1B CCT5 NAV1 DHX29	1.06e-03	1431	51	8	37142655
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	KDM3A CAND1 CSE1L SEC23IP DHX29	1.09e-03	533	51	5	25544563
Pubmed	EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.	MYH9 CSE1L MAP1B CCT5 C18orf63 SUZ12	1.11e-03	803	51	6	36517590
Pubmed	TXLNA enhances TBK1 phosphorylation by suppressing PPM1B recruitment.	CCT5 CAST PFDN5	1.11e-03	138	51	3	37506885
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	MYH9 MAP1B NSD2 SEC23IP ZSCAN26 ABCC5 SREK1 SFMBT2	1.11e-03	1442	51	8	35575683
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	MYH9 CAND1 CSE1L CCT5 BEX5 HYDIN	1.13e-03	807	51	6	30575818
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	MYH9 CAND1 CCT5 CAST PFDN5	1.14e-03	538	51	5	28524877
Pubmed	A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease.	NAV1 HYDIN	1.22e-03	35	51	2	23936387
Pubmed	The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3.	MYH9 CAND1 CSE1L MAP1B CCT5	1.27e-03	552	51	5	36293380
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	MYH9 CSE1L MAP1B CCT5 NAV1 PFDN5 DHX29	1.31e-03	1139	51	7	36417873
Pubmed	TRiC controls transcription resumption after UV damage by regulating Cockayne syndrome protein A.	CCT5 PFDN5	1.36e-03	37	51	2	29531219
Pubmed	Reverse engineering a mouse embryonic stem cell-specific transcriptional network reveals a new modulator of neuronal differentiation.	MYH9 SUZ12	1.36e-03	37	51	2	23180766
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CAND1 MAP1B NSD2 SBF2 CAST FBRSL1 NAV1 SFMBT2	1.37e-03	1489	51	8	28611215
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	MYH9 CAND1 CSE1L MAP1B CCT5 CAST PFDN5	1.37e-03	1149	51	7	35446349
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	IVL MYH9 CGN CAST DHX29	1.41e-03	565	51	5	25468996
Pubmed	Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling.	MYH9 CAND1 SEC23IP CDKAL1	1.43e-03	332	51	4	29053956
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	CSE1L EP400 CCT5 CAST	1.43e-03	332	51	4	32786267
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	MYH9 SEC23IP CAST DHX29 CDKAL1	1.44e-03	568	51	5	37774976
Pubmed	Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN.	MYH9 MAP1B CCT5 CGN	1.46e-03	334	51	4	30425250
Interaction	HDAC1 interactions	DACT1 MYH9 EP400 CCT5 NSD2 SMYD1 RNF113A SEC23IP WRN NAV1 PFDN5 SUZ12 AIM2	2.07e-06	1108	50	13	int:HDAC1
Interaction	SPATA16 interactions	MYH9 SPATA16	6.03e-06	2	50	2	int:SPATA16
Interaction	RBBP7 interactions	MYH9 EP400 MAP1B CCT5 RNF113A PFDN5 SUZ12 AIM2	3.22e-05	507	50	8	int:RBBP7
Interaction	PES1 interactions	MYH9 CAND1 MAP1B RNF113A SUZ12 AIM2	4.12e-05	258	50	6	int:PES1
Cytoband	5q12.3	TRAPPC13 SREK1	1.83e-04	18	51	2	5q12.3
Cytoband	8p12	WRN TEX15	1.27e-03	47	51	2	8p12
Cytoband	12q24.33	EP400 FBRSL1	1.32e-03	48	51	2	12q24.33
Cytoband	2p11.2	KDM3A SMYD1	2.33e-03	64	51	2	2p11.2
Cytoband	Ensembl 112 genes in cytogenetic band chr5q12	TRAPPC13 SREK1	2.48e-03	66	51	2	chr5q12
Cytoband	Ensembl 112 genes in cytogenetic band chr8p12	WRN TEX15	2.94e-03	72	51	2	chr8p12
Cytoband	1q21	IVL CGN	4.65e-03	91	51	2	1q21
GeneFamily	Exonucleases	WRN ERI2	4.05e-04	16	34	2	544
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	NSD2 SMYD1	1.85e-03	34	34	2	487
GeneFamily	Sterile alpha motif domain containing	SEC23IP SFMBT2	1.19e-02	88	34	2	760
Coexpression	GSE1925_CTRL_VS_24H_IFNG_STIM_MACROPHAGE_DN	NAV1 ABCC5 SREK1 ERI2 ARMCX2	3.50e-05	195	50	5	M6294
Coexpression	GSE3982_NEUTROPHIL_VS_TH2_DN	CSE1L EP400 NSD2 BCAT2 ARMCX2	3.76e-05	198	50	5	M5535
Coexpression	GSE11924_TFH_VS_TH1_CD4_TCELL_UP	MYH9 ZSCAN26 CAST TCIRG1 FHIP1A	3.85e-05	199	50	5	M3151
Coexpression	GSE24026_PD1_LIGATION_VS_CTRL_IN_ACT_TCELL_LINE_DN	KDM3A CAND1 CSE1L CCT5 WRN	3.94e-05	200	50	5	M4538
Coexpression	GSE23505_UNTREATED_VS_4DAY_IL6_IL1_TGFB_TREATED_CD4_TCELL_DN	MAP1B ABCC5 SREK1 FHIP1A CDKAL1	3.94e-05	200	50	5	M7868
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HDA	DACT1 SEMA6D MAP1B RNF113A CGN BEX5 CCDC136	4.67e-05	506	50	7	M39067
CoexpressionAtlas	dev gonad_e12.5_F_VasAssMesen_MafB_top-relative-expression-ranked_200	KDM3A CGN ANO1 TEX15 AIM2	3.17e-05	152	51	5	gudmap_dev gonad_e12.5_F_VasAssMesen_MafB_200
CoexpressionAtlas	dev gonad_e12.5_F_VasAssMesen_MafB_k-means-cluster#2_top-relative-expression-ranked_500	KDM3A SEMA6D CGN ANO1	6.20e-05	89	51	4	gudmap_dev gonad_e12.5_F_VasAssMesen_MafB_k2_500
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ABCC5 BCAT2 SREK1 CNBD2 CDKAL1	2.56e-06	190	51	5	651a1d3ae286e40f9d9f60e438211c6148d24143
ToppCell	Adult-Mesenchymal-myofibroblast_cell-D175\|Adult / Lineage, Cell type, age group and donor	ANO1 COLGALT2 CNBD2 CCDC136	3.46e-05	161	51	4	048b7dc00746987a24bf870d4d278c4183eb04a2
ToppCell	facs-Heart-RA-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRACD SMYD1 ADAM30 ERI2	3.55e-05	162	51	4	593939be9d38690c89c31d4c58e351de26cbf9ab
ToppCell	facs-Heart-RA-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRACD SMYD1 ADAM30 ERI2	3.55e-05	162	51	4	3a61eda548afa2a41bdf6293d1050103dc210e52
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L3-6_PVALB_MFI2_(Chandelier_2)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRRC63 CRACD CGN ANO1	5.01e-05	177	51	4	4f88ea4cfcfa8a9af5a14ab6f6be3b2aa015852e
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CRACD SEMA6D ANO1 TEX15	6.07e-05	186	51	4	77592a6397b44b2b59a4fc39d7224dd95343efe6
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA6D CGN ABCC5 FHIP1A	6.20e-05	187	51	4	f124d2c699b717b7c02a1a70493f515b83dc2f4c
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CRACD SEMA6D ANO1 TEX15	6.33e-05	188	51	4	8268574584e5fb869a6cb8bbd7135cd7454a6a25
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CRACD SEMA6D ANO1 TEX15	6.33e-05	188	51	4	4544552ebd67e9eb3e40d8511bb2b03a6e1178f8
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CRACD SEMA6D ANO1 TEX15	6.33e-05	188	51	4	3139540a656c0436b2123ea50741ff8d00112165
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CRACD SEMA6D ANO1 TEX15	6.46e-05	189	51	4	222e67d3fd106c43b0cae6538dddeaa7be1f759f
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DACT1 MYH9 SEMA6D ANO1	6.46e-05	189	51	4	f75cebd4c3e54e297557449ba67ccc8d1a2a14f5
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA6D CGN ABCC5 FHIP1A	6.46e-05	189	51	4	e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CRACD SEMA6D ANO1 TEX15	6.59e-05	190	51	4	59720dfe9de1b980807644536c919d2a02ba69dd
ToppCell	11.5-Distal-Mesenchymal-Airway_Smooth_Muscle\|Distal / Age, Tissue, Lineage and Cell class	DACT1 SEMA6D ANO1 COLGALT2	7.44e-05	196	51	4	05530fe7a5681c2f39b95016cd22ef99d6ac0430
ToppCell	Neuronal-Inhibitory-iA-iA_2(LAMP5)-CA1-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CRACD SEMA6D ANO1 TEX15	8.04e-05	200	51	4	ca5401b76ab014080914bf78042d368cf318effa
ToppCell	Neuronal-Inhibitory-iA-iA_2(LAMP5)-CA1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CRACD SEMA6D ANO1 TEX15	8.04e-05	200	51	4	40286010bd17cf9e34ecd5440953b072ebfae208
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Pericyte-Pericyte_2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	MYH9 SEMA6D MAP1B ANO1	8.04e-05	200	51	4	786f1ae53e60b5ffbf4bfd393d10b802478148b3
ToppCell	LPS_only-Mesenchymal_myocytic-Pericyte\|LPS_only / Treatment groups by lineage, cell group, cell type	DACT1 SEMA6D MAP1B ANO1	8.04e-05	200	51	4	8c8ef2b19ab5b1bfc0fae6c38a330f464f28e86f
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Pericyte\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DACT1 SEMA6D MAP1B ANO1	8.04e-05	200	51	4	b22cae282591d8dead9869c2adbb9632615f50f7
ToppCell	Neuronal-Inhibitory-iA-iA_2(LAMP5)-CA1--L2-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CRACD SEMA6D ANO1 TEX15	8.04e-05	200	51	4	70c47d3bbe67d88c5b9dff99c33a603d25fa2ab0
Disease	longevity	CSE1L SPATA16 WRN SUZ12 TEX15	9.73e-05	284	48	5	EFO_0004300
Disease	male infertility (implicated_via_orthology)	CFAP47 SPATA16	2.00e-04	13	48	2	DOID:12336 (implicated_via_orthology)
Disease	attention deficit hyperactivity disorder, autism spectrum disorder, intelligence	SEMA6D WRN NAV1 FHIP1A CDKAL1	4.63e-04	398	48	5	EFO_0003756, EFO_0003888, EFO_0004337
Disease	disease	SPATA16 BCAT2	5.34e-04	21	48	2	EFO_0000408
Disease	Colorectal Carcinoma	DACT1 CSE1L MAP1B WRN ABCC5 ERI2	9.31e-04	702	48	6	C0009402
Disease	fasting blood glucose change measurement	WRN CDKAL1	1.25e-03	32	48	2	EFO_0010120
Disease	ascending aortic diameter	CAST ANO1 HYDIN	1.55e-03	140	48	3	EFO_0021787
Disease	Malignant neoplasm of breast	KDM3A MYH9 CCT5 NSD2 MRPL19 COLGALT2 FSCB	1.66e-03	1074	48	7	C0006142
Disease	aortic stenosis, aortic valve calcification	FBRSL1 NAV1	2.14e-03	42	48	2	EFO_0000266, EFO_0005239
Disease	age at menarche	SEMA6D SEC23IP CAST FBRSL1 CDKAL1	2.73e-03	594	48	5	EFO_0004703
Disease	atrial fibrillation	LRRC63 KDM3A FBRSL1 CCDC136	3.09e-03	371	48	4	EFO_0000275

Protein segments in the cluster

Peptide	Gene	Start	Entry
KEPKNIINPHEKVQM	ERI2	281	A8K979
HLIKMQKQKLQMPPQ	EP400	2816	Q96L91
QQKIKEMQLDPHKLE	FBRSL1	606	Q9HCM7
KVSPHVKPEQKQMVA	AIM2	126	O14862
AMKISHQQNERKKPP	DHX29	316	Q7Z478
PIIANMINKTDPHIK	ARMCX2	431	Q7L311
VPENLKNPEPNIKMK	MAP1B	361	P46821
QQTDVIEKKKHMAIP	FSCB	6	Q5H9T9
IKVEENNPVKMIKHV	SBF2	441	Q86WG5
MENVPKENKVVEKAP	BEX5	1	Q5H9J7
QVPNIVKALHKQMKE	CAND1	431	Q86VP6
TKQMEKIQPALQEKH	PFDN5	111	Q99471
PKNVPPNIQKMKHEI	NSD2	901	O96028
VMQEQGTHPKFQKPK	MYH9	546	P35579
VIAQKLEKMHPKHQP	LRRC63	166	Q05C16
PKDISQQIHKEKVLM	ANO1	916	Q5XXA6
PEKKRVTHNPMIQKT	RNF113A	56	O15541
NKPASPHIKIEMKNA	ABCC5	481	O15440
VIGNHLKPKQEKMPL	ADAM30	711	Q9UKF2
IDPPKHIQEMKKNAL	FHIP1A	611	Q05DH4
QSQKPVDKLEKHMPK	HYDIN	1736	Q4G0P3
NKEKQPTMPILKNEI	KDM3A	836	Q9Y4C1
PPQENKVVQPLKKMS	DACT1	496	Q9NYF0
PAAKMEQVPAQVKKQ	CDKAL1	401	Q5VV42
PEHDKAANKMPLAQK	CRACD	946	Q6ZU35
VSQQMEGPHLPNKKK	CAST	11	P20810
KRMQVKEPEKAVPNV	COLGALT2	471	Q8IYK4
DLQLEMTQKPHKKPG	BCAT2	36	O15382
EIPLHEMNPNNKVTK	CFAP47	1201	Q6ZTR5
QEHKVKPPNLTTKKM	C18orf63	326	Q68DL7
EQCRLMHIQPPKKKN	MED19	161	A0JLT2
RMPPQHIIKGDLKQQ	NAV1	1426	Q8NEY1
VKDNPKPSQEVVKEM	SMYD1	291	Q8NB12
HPQMPKKVEDAKIAI	CCT5	236	P48643
HPPNILEMSQEIKKN	SPATA16	36	Q9BXB7
VEARQKHANKMDVPP	WRN	1161	Q14191
KQLHFQEKQMPEEPK	SEC23IP	616	Q9Y6Y8
KINHSNNAIVKPPEM	SREK1	136	Q8WXA9
KQPELPEQQMGQLKH	IVL	301	P07476
KPMAPQNDKNEIKEL	CCDC136	911	Q96JN2
MELQNKLKHVQGPEP	CGN	446	Q9P2M7
EGHFPPKAIQIMQKK	CNBD2	81	Q96M20
PNQKVPVNELKVKMK	MRPL19	211	P49406
KKEHDPVGQMVNNPK	CSE1L	911	P55060
AAVLPVKKPKMEHVQ	SUZ12	66	Q15022
QNNKVLMPPDAIKEK	SFMBT2	136	Q5VUG0
PDQPKKQKILVEEMA	ZSCAN26	141	Q16670
KEKMNIHIVKPGENN	TEX15	2271	Q9BXT5
NLNEMPKTEVIPNKK	SEMA6D	81	Q8NFY4
MEVNPPKQEHLLALK	TRAPPC13	1	A5PLN9
LQLLPPGQVQVHKMK	TCIRG1	286	Q13488