Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	endopeptidase activity	USP6 ADAMTS1 ADAMTS9 PRSS12 PLAU ADAM22	9.40e-04	430	53	6	GO:0004175
GeneOntologyMolecularFunction	scaffold protein binding	BIRC8 PSAP CD163	1.94e-03	93	53	3	GO:0097110
GeneOntologyMolecularFunction	protein-cysteine S-palmitoyltransferase activity	ZDHHC11B ZDHHC11	2.16e-03	26	53	2	GO:0019706
GeneOntologyMolecularFunction	protein-cysteine S-acyltransferase activity	ZDHHC11B ZDHHC11	2.16e-03	26	53	2	GO:0019707
GeneOntologyMolecularFunction	zinc ion binding	ZCCHC4 LIG3 ADAMTS1 ADAMTS9 TRIM8 RNF216 TRIM21 CHD4	2.27e-03	891	53	8	GO:0008270
GeneOntologyMolecularFunction	Notch binding	ATRNL1 NOTCH1	2.33e-03	27	53	2	GO:0005112
GeneOntologyMolecularFunction	S-acyltransferase activity	ZDHHC11B ZDHHC11	2.87e-03	30	53	2	GO:0016417
GeneOntologyBiologicalProcess	myelination	ATRN PSAP MTOR CNTNAP2 ITGB4 ADAM22	1.28e-05	206	52	6	GO:0042552
GeneOntologyBiologicalProcess	axon ensheathment	ATRN PSAP MTOR CNTNAP2 ITGB4 ADAM22	1.39e-05	209	52	6	GO:0008366
GeneOntologyBiologicalProcess	ensheathment of neurons	ATRN PSAP MTOR CNTNAP2 ITGB4 ADAM22	1.39e-05	209	52	6	GO:0007272
GeneOntologyBiologicalProcess	regulation of viral transcription	TRIM8 TRIM21 NOTCH1	3.34e-05	25	52	3	GO:0046782
GeneOntologyBiologicalProcess	regulation of postsynaptic membrane neurotransmitter receptor levels	USP6 NETO1 CNTNAP2 RNF216 ADAM22	5.75e-05	164	52	5	GO:0099072
GeneOntologyCellularComponent	glutamatergic synapse	SEMA3F USP6 NETO1 MTOR PRSS12 CNTNAP2 RNF216 CHD4 ITGB4 ADAM22 NOTCH1	4.23e-06	817	52	11	GO:0098978
GeneOntologyCellularComponent	cerebellar granule cell to Purkinje cell synapse	CNTNAP2 CHD4	1.26e-04	7	52	2	GO:0150048
GeneOntologyCellularComponent	Schaffer collateral - CA1 synapse	NETO1 PRSS12 RNF216 NOTCH1	5.97e-04	155	52	4	GO:0098685
GeneOntologyCellularComponent	extracellular matrix	ANOS1 PSAP ADAMTS1 ADAMTS9 SPON1 LOXL3 ITGB4	1.14e-03	656	52	7	GO:0031012
GeneOntologyCellularComponent	asymmetric synapse	USP6 NETO1 CNTNAP2 CHD4 ADAM22 NOTCH1	1.15e-03	477	52	6	GO:0032279
GeneOntologyCellularComponent	external encapsulating structure	ANOS1 PSAP ADAMTS1 ADAMTS9 SPON1 LOXL3 ITGB4	1.16e-03	658	52	7	GO:0030312
GeneOntologyCellularComponent	asymmetric, glutamatergic, excitatory synapse	CNTNAP2 CHD4	1.62e-03	24	52	2	GO:0098985
GeneOntologyCellularComponent	neuron to neuron synapse	USP6 NETO1 CNTNAP2 CHD4 ADAM22 NOTCH1	1.83e-03	523	52	6	GO:0098984
GeneOntologyCellularComponent	collagen-containing extracellular matrix	PSAP ADAMTS1 ADAMTS9 SPON1 LOXL3 ITGB4	1.96e-03	530	52	6	GO:0062023
GeneOntologyCellularComponent	axon initial segment	CNTNAP2 ADAM22	2.36e-03	29	52	2	GO:0043194
GeneOntologyCellularComponent	excitatory synapse	NETO1 CNTNAP2 CHD4	2.40e-03	107	52	3	GO:0060076
Domain	EGF_1	ATRN FAT4 ATRNL1 CNTNAP2 SCUBE3 PLAU LRP1B ITGB4 ADAM22 NOTCH1	1.20e-09	255	50	10	PS00022
Domain	EGF-like_CS	ATRN FAT4 ATRNL1 CNTNAP2 SCUBE3 PLAU LRP1B ITGB4 ADAM22 NOTCH1	1.50e-09	261	50	10	IPR013032
Domain	EGF_2	ATRN FAT4 ATRNL1 CNTNAP2 SCUBE3 PLAU LRP1B ITGB4 ADAM22 NOTCH1	1.74e-09	265	50	10	PS01186
Domain	EGF_3	ATRN FAT4 ATRNL1 CNTNAP2 SCUBE3 PLAU LRP1B ADAM22 NOTCH1	1.08e-08	235	50	9	PS50026
Domain	EGF	ATRN FAT4 ATRNL1 CNTNAP2 SCUBE3 PLAU LRP1B ADAM22 NOTCH1	1.08e-08	235	50	9	SM00181
Domain	EGF_extracell	ATRN ATRNL1 LRP1B ITGB4 ADAM22 NOTCH1	1.21e-08	60	50	6	IPR013111
Domain	EGF_2	ATRN ATRNL1 LRP1B ITGB4 ADAM22 NOTCH1	1.21e-08	60	50	6	PF07974
Domain	EGF-like_dom	ATRN FAT4 ATRNL1 CNTNAP2 SCUBE3 PLAU LRP1B ADAM22 NOTCH1	1.79e-08	249	50	9	IPR000742
Domain	PSI	SEMA3F ATRN ATRNL1 ITGB4	5.70e-06	44	50	4	IPR016201
Domain	PSI	SEMA3F ATRN ATRNL1 ITGB4	6.83e-06	46	50	4	SM00423
Domain	CUB	ATRN NETO1 ATRNL1 SCUBE3	8.81e-06	49	50	4	PF00431
Domain	CUB	ATRN NETO1 ATRNL1 SCUBE3	9.56e-06	50	50	4	SM00042
Domain	-	ATRN NETO1 ATRNL1 SCUBE3	1.12e-05	52	50	4	2.60.120.290
Domain	CUB	ATRN NETO1 ATRNL1 SCUBE3	1.21e-05	53	50	4	PS01180
Domain	CUB_dom	ATRN NETO1 ATRNL1 SCUBE3	1.62e-05	57	50	4	IPR000859
Domain	-	RASA4 RASA4B	2.10e-05	3	50	2	4.10.1130.10
Domain	EGF	ATRN CNTNAP2 SCUBE3 LRP1B NOTCH1	2.14e-05	126	50	5	PF00008
Domain	SRCR	PRSS12 LOXL3 CD163	2.32e-05	21	50	3	PF00530
Domain	SR	PRSS12 LOXL3 CD163	3.98e-05	25	50	3	SM00202
Domain	-	PRSS12 LOXL3 CD163	3.98e-05	25	50	3	3.10.250.10
Domain	SRCR_1	PRSS12 LOXL3 CD163	4.49e-05	26	50	3	PS00420
Domain	SRCR_2	PRSS12 LOXL3 CD163	4.49e-05	26	50	3	PS50287
Domain	SRCR-like_dom	PRSS12 LOXL3 CD163	4.49e-05	26	50	3	IPR017448
Domain	SRCR	PRSS12 LOXL3 CD163	5.05e-05	27	50	3	IPR001190
Domain	Growth_fac_rcpt_	ATRN FAT4 SCUBE3 LRP1B NOTCH1	5.96e-05	156	50	5	IPR009030
Domain	EGF_CA	FAT4 SCUBE3 LRP1B NOTCH1	8.21e-05	86	50	4	PF07645
Domain	EGF_Ca-bd_CS	FAT4 SCUBE3 LRP1B NOTCH1	1.31e-04	97	50	4	IPR018097
Domain	EGF_CA	FAT4 SCUBE3 LRP1B NOTCH1	1.42e-04	99	50	4	PS01187
Domain	ASX_HYDROXYL	FAT4 SCUBE3 LRP1B NOTCH1	1.47e-04	100	50	4	PS00010
Domain	Peptidase_M12B_N	ADAMTS1 ADAMTS9 ADAM22	1.54e-04	39	50	3	IPR002870
Domain	Pep_M12B_propep	ADAMTS1 ADAMTS9 ADAM22	1.54e-04	39	50	3	PF01562
Domain	DISINTEGRIN_1	ADAMTS1 ADAMTS9 ADAM22	1.66e-04	40	50	3	PS00427
Domain	Reprolysin	ADAMTS1 ADAMTS9 ADAM22	1.66e-04	40	50	3	PF01421
Domain	ADAM_MEPRO	ADAMTS1 ADAMTS9 ADAM22	1.66e-04	40	50	3	PS50215
Domain	DISINTEGRIN_2	ADAMTS1 ADAMTS9 ADAM22	1.66e-04	40	50	3	PS50214
Domain	Peptidase_M12B	ADAMTS1 ADAMTS9 ADAM22	1.66e-04	40	50	3	IPR001590
Domain	Disintegrin_dom	ADAMTS1 ADAMTS9 ADAM22	1.79e-04	41	50	3	IPR001762
Domain	EGF-type_Asp/Asn_hydroxyl_site	FAT4 SCUBE3 LRP1B NOTCH1	1.85e-04	106	50	4	IPR000152
Domain	BTK	RASA4 RASA4B	2.50e-04	9	50	2	SM00107
Domain	Znf_Btk_motif	RASA4 RASA4B	2.50e-04	9	50	2	IPR001562
Domain	BTK	RASA4 RASA4B	2.50e-04	9	50	2	PF00779
Domain	ZF_BTK	RASA4 RASA4B	2.50e-04	9	50	2	PS51113
Domain	EGF_CA	FAT4 SCUBE3 LRP1B NOTCH1	3.16e-04	122	50	4	SM00179
Domain	EGF-like_Ca-bd_dom	FAT4 SCUBE3 LRP1B NOTCH1	3.37e-04	124	50	4	IPR001881
Domain	RasGAP	RASA4 RASA4B	6.26e-04	14	50	2	SM00323
Domain	RasGAP_CS	RASA4 RASA4B	6.26e-04	14	50	2	IPR023152
Domain	TSP_1	ADAMTS1 ADAMTS9 SPON1	6.40e-04	63	50	3	PF00090
Domain	TSP1	ADAMTS1 ADAMTS9 SPON1	7.02e-04	65	50	3	SM00209
Domain	TSP1_rpt	ADAMTS1 ADAMTS9 SPON1	7.02e-04	65	50	3	IPR000884
Domain	TSP1	ADAMTS1 ADAMTS9 SPON1	7.02e-04	65	50	3	PS50092
Domain	RasGAP	RASA4 RASA4B	7.21e-04	15	50	2	PF00616
Domain	RAS_GTPASE_ACTIV_1	RASA4 RASA4B	7.21e-04	15	50	2	PS00509
Domain	RAS_GTPASE_ACTIV_2	RASA4 RASA4B	7.21e-04	15	50	2	PS50018
Domain	-	RASA4 RASA4B	8.23e-04	16	50	2	1.10.506.10
Domain	Kringle	PRSS12 PLAU	9.31e-04	17	50	2	IPR000001
Domain	Kringle_CS	PRSS12 PLAU	9.31e-04	17	50	2	IPR018056
Domain	KRINGLE_2	PRSS12 PLAU	9.31e-04	17	50	2	PS50070
Domain	Kringle	PRSS12 PLAU	9.31e-04	17	50	2	PF00051
Domain	KRINGLE_1	PRSS12 PLAU	9.31e-04	17	50	2	PS00021
Domain	KR	PRSS12 PLAU	9.31e-04	17	50	2	SM00130
Domain	RasGAP_dom	RASA4 RASA4B	1.05e-03	18	50	2	IPR001936
Domain	MetalloPept_cat_dom	ADAMTS1 ADAMTS9 ADAM22	1.33e-03	81	50	3	IPR024079
Domain	-	ADAMTS1 ADAMTS9 ADAM22	1.33e-03	81	50	3	3.40.390.10
Domain	ADAM_spacer1	ADAMTS1 ADAMTS9	1.71e-03	23	50	2	IPR010294
Domain	ADAM_spacer1	ADAMTS1 ADAMTS9	1.71e-03	23	50	2	PF05986
Domain	Peptidase_M12B_ADAM-TS	ADAMTS1 ADAMTS9	1.87e-03	24	50	2	IPR013273
Domain	DHHC	ZCCHC4 ZDHHC11	2.03e-03	25	50	2	PS50216
Domain	Znf_DHHC_palmitoyltrfase	ZCCHC4 ZDHHC11	2.03e-03	25	50	2	IPR001594
Domain	cEGF	SCUBE3 LRP1B	2.19e-03	26	50	2	IPR026823
Domain	cEGF	SCUBE3 LRP1B	2.19e-03	26	50	2	PF12662
Domain	-	WDR19 ZC3H7A MTOR WDTC1	2.27e-03	207	50	4	1.25.40.10
Domain	ZINC_PROTEASE	ADAMTS1 ADAMTS9 ADAM22	2.30e-03	98	50	3	PS00142
Domain	ACR	ADAMTS1 ADAM22	2.36e-03	27	50	2	SM00608
Domain	ADAM_Cys-rich	ADAMTS1 ADAM22	2.36e-03	27	50	2	IPR006586
Domain	hEGF	FAT4 NOTCH1	2.54e-03	28	50	2	PF12661
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	ADAMTS1 ADAMTS9 SPON1 NOTCH1	3.23e-05	68	38	4	M27303
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS1 ADAMTS9 SPON1	1.54e-04	39	38	3	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS1 ADAMTS9 SPON1	1.54e-04	39	38	3	MM15165
Pubmed	Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome.	ADAMTS1 ADAMTS9 NOTCH1	2.95e-07	9	54	3	23095891
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	WDR19 ATRN PSAP ADAMTS1 ADAMTS9 NETO1 ATRNL1 TRIM8 RNF216 CHD4 LRP1B ADAM22	5.01e-07	1285	54	12	35914814
Pubmed	ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma.	ZDHHC11B ZDHHC11	2.37e-06	2	54	2	28331227
Pubmed	Akt-mTOR signaling is involved in Notch-1-mediated glioma cell survival and proliferation.	MTOR NOTCH1	2.37e-06	2	54	2	20372862
Pubmed	Macrophage-released ADAMTS1 promotes muscle stem cell activation.	ADAMTS1 NOTCH1	2.37e-06	2	54	2	28939843
Pubmed	CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.	RASA4 RASA4B	2.37e-06	2	54	2	11448776
Pubmed	Growth inhibitory effect of rapamycin in Hodgkin-lymphoma cell lines characterized by constitutive NOTCH1 activation.	MTOR NOTCH1	2.37e-06	2	54	2	27473087
Pubmed	Abnormal expressions of ADAMTS-1, ADAMTS-9 and progesterone receptors are associated with lower oocyte maturation in women with polycystic ovary syndrome.	ADAMTS1 ADAMTS9	2.37e-06	2	54	2	30446843
Pubmed	Uniform expression of Notch1, suppressor of B-cell-specific gene expression, in plasmablastic lymphoma.	MTOR NOTCH1	2.37e-06	2	54	2	21631271
Pubmed	Genetic analysis of attractin homologs.	ATRN ATRNL1	2.37e-06	2	54	2	18064672
Pubmed	An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.	RASA4 RASA4B	2.37e-06	2	54	2	16041389
Pubmed	Testis-specific hnRNP is expressed in colorectal cancer cells and accelerates cell growth mediating ZDHHC11 mRNA stabilization.	ZDHHC11B ZDHHC11	2.37e-06	2	54	2	35384384
Pubmed	Mutual regulation between TRIM21 and TRIM8 via K48-linked ubiquitination.	TRIM8 TRIM21	2.37e-06	2	54	2	37914816
Pubmed	Hyperactive Akt-mTOR pathway as a therapeutic target for pain hypersensitivity in Cntnap2-deficient mice.	MTOR CNTNAP2	7.09e-06	3	54	2	31874168
Pubmed	NOTCH knockdown affects the proliferation and mTOR signaling of leukemia cells.	MTOR NOTCH1	7.09e-06	3	54	2	24122995
Pubmed	Targeted knockdown of Notch1 inhibits invasion of human prostate cancer cells concomitant with inhibition of matrix metalloproteinase-9 and urokinase plasminogen activator.	PLAU NOTCH1	7.09e-06	3	54	2	19147749
Pubmed	Specific knockdown of uPA/uPAR attenuates invasion in glioblastoma cells and xenografts by inhibition of cleavage and trafficking of Notch -1 receptor.	PLAU NOTCH1	7.09e-06	3	54	2	22004682
Pubmed	Differential gene expression of ADAMTS-1, ADAMTS-9 and TIMP-3 in periodontitis.	ADAMTS1 ADAMTS9	7.09e-06	3	54	2	36093887
Pubmed	CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane.	RASA4 RASA4B	7.09e-06	3	54	2	25637021
Pubmed	ZDHHC19 localizes to the cell membrane of spermatids and is involved in spermatogenesis†.	ZDHHC11B ZDHHC11	7.09e-06	3	54	2	34897408
Pubmed	ADAMTS9 is a functional tumor suppressor through inhibiting AKT/mTOR pathway and associated with poor survival in gastric cancer.	ADAMTS9 MTOR	7.09e-06	3	54	2	22907434
Pubmed	Oroxylin A induces autophagy in human malignant glioma cells via the mTOR-STAT3-Notch signaling pathway.	MTOR NOTCH1	7.09e-06	3	54	2	25213258
Pubmed	Inflammation-induced colon cancer in uPA-deficient mice is associated with a deregulated expression of Notch signaling pathway components.	PLAU NOTCH1	7.09e-06	3	54	2	31758376
Pubmed	ADAMTS1, ADAMTS5, ADAMTS9 and aggrecanase-generated proteoglycan fragments are induced following spinal cord injury in mouse.	ADAMTS1 ADAMTS9	7.09e-06	3	54	2	23562508
Pubmed	Knockdown of Notch1 inhibits nasopharyngeal carcinoma cell growth and metastasis via downregulation of CCL2, CXCL16, and uPA.	PLAU NOTCH1	1.42e-05	4	54	2	31270884
Pubmed	Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.	RASA4 RASA4B	1.42e-05	4	54	2	21460216
Pubmed	Notch-modifying xylosyltransferase structures support an SNi-like retaining mechanism.	XYLT1 NOTCH1	1.42e-05	4	54	2	26414444
Pubmed	ZDHHC11 modulates innate immune response to DNA virus by mediating MITA-IRF3 association.	ZDHHC11B ZDHHC11	1.42e-05	4	54	2	29429998
Pubmed	Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding.	RASA4 RASA4B	1.42e-05	4	54	2	16234249
Pubmed	ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons.	CNTNAP2 ADAM22	2.36e-05	5	54	2	20089912
Pubmed	Notch inhibits apoptosis by direct interference with XIAP ubiquitination and degradation.	BIRC8 NOTCH1	2.36e-05	5	54	2	17318174
Pubmed	Genetic and phenotypic studies of the dark-like mutant mouse.	ATRN ATRNL1	2.36e-05	5	54	2	18821597
Pubmed	Regulation of aggrecanases from the ADAMTS family and aggrecan neoepitope formation during in vitro chondrogenesis of human mesenchymal stem cells.	ADAMTS1 ADAMTS9	2.36e-05	5	54	2	22562232
Pubmed	Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation.	ADAMTS1 ADAMTS9 NOTCH1	2.87e-05	38	54	3	29743679
Pubmed	PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.	SEMA3F ATRN NETO1 ADAM22	3.38e-05	117	54	4	17145500
Pubmed	The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein.	PLAU LRP1B	3.54e-05	6	54	2	11384978
Pubmed	Proteolytic cleavage of versican during cardiac cushion morphogenesis.	ADAMTS1 ADAMTS9	3.54e-05	6	54	2	16691565
Pubmed	ZDHHC11 Positively Regulates NF-κB Activation by Enhancing TRAF6 Oligomerization.	ZDHHC11B ZDHHC11	3.54e-05	6	54	2	34490261
Pubmed	The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican.	ADAMTS1 ADAMTS9	4.94e-05	7	54	2	15599946
Pubmed	In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.	ZDHHC11B ZDHHC11	4.94e-05	7	54	2	23687301
Pubmed	Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults.	ADAMTS1 ADAMTS9	4.94e-05	7	54	2	23354118
Pubmed	Comparative genome mapping in the sequence-based era: early experience with human chromosome 7.	RASA4 RASA4B	6.59e-05	8	54	2	10810084
Pubmed	FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping.	MTOR NOTCH1	6.59e-05	8	54	2	33086033
Pubmed	Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells.	MTOR ITGB4	6.59e-05	8	54	2	12105188
Pubmed	BANK1 and BLK act through phospholipase C gamma 2 in B-cell signaling.	PSAP CD163	8.46e-05	9	54	2	23555801
Pubmed	TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation.	TRIM8 TRIM21	8.46e-05	9	54	2	22829933
Pubmed	Expression of signaling components in embryonic eyelid epithelium.	ADAMTS1 NOTCH1	1.06e-04	10	54	2	24498290
Pubmed	PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development.	ADAMTS1 ADAMTS9 NOTCH1	1.08e-04	59	54	3	38374152
Pubmed	Zinc transporter Slc39a8 is essential for cardiac ventricular compaction.	ADAMTS1 NOTCH1	1.29e-04	11	54	2	29337306
Pubmed	Missense Mutation in Human CHD4 Causes Ventricular Noncompaction by Repressing ADAMTS1.	ADAMTS1 CHD4	1.29e-04	11	54	2	37254794
Pubmed	Hydrocephalus in mouse B3glct mutants is likely caused by defects in multiple B3GLCT substrates in ependymal cells and subcommissural organ.	ADAMTS9 SPON1	1.29e-04	11	54	2	33909046
Pubmed	The NuRD chromatin-remodeling enzyme CHD4 promotes embryonic vascular integrity by transcriptionally regulating extracellular matrix proteolysis.	PLAU CHD4	1.29e-04	11	54	2	24348274
Pubmed	Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.	PSAP ADAMTS9 SPON1	1.38e-04	64	54	3	22261194
Pubmed	CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity.	PLAU CHD4	1.55e-04	12	54	2	27140400
Pubmed	Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.	ADAMTS1 ADAMTS9	1.55e-04	12	54	2	25770910
Pubmed	Decidual PTEN expression is required for trophoblast invasion in the mouse.	BIRC8 MTOR	1.83e-04	13	54	2	20858757
Pubmed	Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth.	ADAMTS1 ADAMTS9	1.83e-04	13	54	2	32909945
Pubmed	Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells.	MTOR NOTCH1	2.13e-04	14	54	2	21349854
Pubmed	Human cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNA.	TRIM21 CHD4	2.13e-04	14	54	2	20585571
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADAMTS1 ADAMTS9 SPON1	2.21e-04	75	54	3	20637190
Pubmed	FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation.	MTOR NOTCH1	2.45e-04	15	54	2	31285543
Pubmed	Sall4 regulates cell fate decision in fetal hepatic stem/progenitor cells.	ITGB4 NOTCH1	2.80e-04	16	54	2	19185577
Pubmed	ADAMTS18 Deficiency Affects Neuronal Morphogenesis and Reduces the Levels of Depression-like Behaviors in Mice.	ADAMTS1 ADAMTS9	2.80e-04	16	54	2	30579834
Pubmed	Suppression of C/EBPalpha expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression.	ITGB4 NOTCH1	2.80e-04	16	54	2	17021047
Pubmed	Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation.	ADAMTS1 ADAMTS9	3.17e-04	17	54	2	22183742
Pubmed	TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity.	TRIM8 TRIM21	3.56e-04	18	54	2	23077300
Pubmed	TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.	TRIM8 TRIM21	3.98e-04	19	54	2	26347139
Pubmed	ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression.	ADAMTS1 ADAMTS9	4.42e-04	20	54	2	19922873
Pubmed	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	PSAP ATRNL1 TRIM8 PLAU ZNF239	4.62e-04	415	54	5	16385451
Pubmed	Canonical notch signaling functions as a commitment switch in the epidermal lineage.	ITGB4 NOTCH1	4.88e-04	21	54	2	17079689
Pubmed	OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer.	MTOR TRIM21	4.88e-04	21	54	2	30662561
Pubmed	Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes.	CNTNAP2 ADAM22	4.88e-04	21	54	2	25707359
Pubmed	TRIM E3 ligases interfere with early and late stages of the retroviral life cycle.	TRIM8 TRIM21	4.88e-04	21	54	2	18248090
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	SEMA3F ATRN FAT4 PSAP LRP1B ITGB4 ADAM22 NOTCH1	5.01e-04	1201	54	8	35696571
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	LRP1B ITGB4 NOTCH1	5.29e-04	101	54	3	23382219
Pubmed	GATA6 Regulates Aortic Valve Remodeling, and Its Haploinsufficiency Leads to Right-Left Type Bicuspid Aortic Valve.	ADAMTS1 ADAMTS9	5.86e-04	23	54	2	29567669
Pubmed	Genome-wide Identification of Foxf2 Target Genes in Palate Development.	ADAMTS9 SPON1	5.86e-04	23	54	2	32040930
Pubmed	Cis-Repression of Foxq1 Expression Affects Foxf2-Mediated Gene Expression in Palate Development.	ADAMTS9 SPON1	5.86e-04	23	54	2	33898467
Pubmed	Aberrant epidermal differentiation and disrupted ΔNp63/Notch regulatory axis in Ets1 transgenic mice.	ITGB4 NOTCH1	5.86e-04	23	54	2	24337118
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	ATRN RASA4 ATRNL1	5.93e-04	105	54	3	9628581
Pubmed	The DNA sequence of human chromosome 7.	RASA4 CNTNAP2 RNF216 RASA4B ADAM22	6.08e-04	441	54	5	12853948
Pubmed	Myocardial Angiopoietin-1 Controls Atrial Chamber Morphogenesis by Spatiotemporal Degradation of Cardiac Jelly.	ADAMTS1 ADAMTS9	6.39e-04	24	54	2	29791855
Pubmed	Etv transcription factors functionally diverge from their upstream FGF signaling in lens development.	MTOR NOTCH1	6.39e-04	24	54	2	32043969
Pubmed	Genetic variation in healthy oldest-old.	MTOR NOTCH1	6.39e-04	24	54	2	19680556
Pubmed	Stromal Fat4 acts non-autonomously with Dchs1/2 to restrict the nephron progenitor pool.	FAT4 NOTCH1	6.39e-04	24	54	2	26116661
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	ATRN ITGB4 CD163 FETUB	6.89e-04	257	54	4	16335952
Pubmed	Common variants at ten loci influence QT interval duration in the QTGEN Study.	ZC3H7A LIG3	6.94e-04	25	54	2	19305408
Pubmed	Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning.	ITGB4 NOTCH1	7.51e-04	26	54	2	25446530
Pubmed	Mass spectrometry-based proteomics revealed Glypican-1 as a novel ADAM17 substrate.	PSAP PLAU ITGB4	7.92e-04	116	54	3	27576135
Pubmed	Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight.	ADAMTS9 NOTCH1	8.10e-04	27	54	2	20490451
Pubmed	mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation.	MTOR ITGB4	8.10e-04	27	54	2	27807348
Pubmed	Impaired Interneuron Development after Foxg1 Disruption.	SEMA3F NOTCH1	9.35e-04	29	54	2	26620267
Pubmed	ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation.	ITGB4 NOTCH1	1.07e-03	31	54	2	22274697
Pubmed	Semaphorin 3E/PlexinD1 signaling is required for cardiac ventricular compaction.	ADAMTS1 NOTCH1	1.14e-03	32	54	2	31434798
Pubmed	Ctip2 controls the differentiation of medium spiny neurons and the establishment of the cellular architecture of the striatum.	SEMA3F NETO1	1.21e-03	33	54	2	18199763
Pubmed	Galnt1 is required for normal heart valve development and cardiac function.	ADAMTS1 ADAMTS9	1.44e-03	36	54	2	25615642
Pubmed	Cardiac-specific developmental and epigenetic functions of Jarid2 during embryonic development.	ADAMTS1 NOTCH1	1.44e-03	36	54	2	29891551
Interaction	DYRK1A interactions	ATRN PSAP ADAMTS1 ADAMTS9 ATRNL1 RNF216 TRIM21 LRP1B ITGB4 ADAM22	1.77e-06	552	54	10	int:DYRK1A
Cytoband	4q28.1	FAT4 PRSS12	1.61e-04	16	54	2	4q28.1
Cytoband	5p15.33	ZDHHC11B ZDHHC11	6.58e-04	32	54	2	5p15.33
GeneFamily	Pleckstrin homology domain containing\|SH2 domain containing\|C2 and RasGAP domain containing	RASA4 RASA4B	2.34e-04	10	42	2	830
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS1 ADAMTS9	8.79e-04	19	42	2	50
GeneFamily	Zinc fingers DHHC-type\|Ankyrin repeat domain containing	ZDHHC11B ZDHHC11	1.41e-03	24	42	2	76
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	ATRN ATRNL1	4.08e-03	41	42	2	1298
Coexpression	GSE360_T_GONDII_VS_B_MALAYI_LOW_DOSE_MAC_UP	XYLT1 LIG3 RNGTT PLAU CHD4 CD163	3.10e-06	196	54	6	M5256
Coexpression	NABA_ECM_REGULATORS	ADAMTS1 ADAMTS9 PRSS12 PLAU LOXL3 ADAM22	9.44e-06	238	54	6	M3468
Coexpression	NABA_ECM_REGULATORS	ADAMTS1 ADAMTS9 PRSS12 PLAU LOXL3 ADAM22	1.04e-05	242	54	6	MM17062
Coexpression	NABA_MATRISOME	SEMA3F ANOS1 ADAMTS1 ADAMTS9 PRSS12 SPON1 SCUBE3 PLAU LOXL3 ADAM22	4.04e-05	1026	54	10	M5889
ToppCell	10x5'-Liver-Myeloid_Mac-Intestinal_macrophages\|Liver / Manually curated celltypes from each tissue	ANOS1 PLA2G2D PLAU LRP1B CD163	1.30e-06	156	54	5	9a897fc79c4fae94c5f2e9012d65297f9225e5e3
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADAMTS1 ADAMTS9 RASA4 RASA4B FRMD3	1.98e-06	170	54	5	1a568efcff9c39b3f709b55a05d24710450a2657
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADAMTS1 ADAMTS9 RASA4 RASA4B FRMD3	1.98e-06	170	54	5	66d41d794790e621d72ac37af995510537103c9c
ToppCell	5'-Adult-LymphNode-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SEMA3F ADAMTS1 ADAMTS9 RASA4 RASA4B	3.41e-06	190	54	5	141266bf411ea675fbf889b20c1b08673c45ff95
ToppCell	Parenchyma_Control_(B.)-Endothelial-TX-Endothelial-1\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	SEMA3F ADAMTS1 ADAMTS9 RASA4 ITGB4	4.06e-06	197	54	5	f969685dee212f33a6f09e54c0cd1fd24ffef546
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial-Endothelial-1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SEMA3F ADAMTS1 ADAMTS9 RASA4 ITGB4	4.06e-06	197	54	5	96d63a8d00583e2aa0a38412e2ae27e23f399493
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial-Endothelial-1\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	SEMA3F ADAMTS1 ADAMTS9 RASA4 ITGB4	4.06e-06	197	54	5	1a137af40697137bb9d2b5caf2b1ffda55f04461
ToppCell	PCW_10-12\|World / Celltypes from embryonic and fetal-stage human lung	USP6 ZDHHC11B PRSS12 SPON1 CNTNAP2	4.06e-06	197	54	5	47fd8b0d596c5db1a722473c8efbb17a6bbe7538
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FAT4 ADAMTS1 PRSS12 ATRNL1 ADAM22	4.27e-06	199	54	5	38cfd367ee8c074c11ba54edeb7a001e375e2687
ToppCell	LPS_only-Endothelial-Endothelial-Vein\|LPS_only / Treatment groups by lineage, cell group, cell type	SEMA3F ADAMTS1 ADAMTS9 RASA4 ITGB4	4.37e-06	200	54	5	b036f5e22c95a3b14391785b6e91aa183b9bc9a8
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Vein\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SEMA3F ADAMTS1 ADAMTS9 RASA4 ITGB4	4.37e-06	200	54	5	b3f93b71589251197cde96b7bc6d065c106f61cd
ToppCell	Control_saline-Endothelial-Endothelial-Vein\|Control_saline / Treatment groups by lineage, cell group, cell type	SEMA3F ADAMTS1 RASA4 LRP1B ITGB4	4.37e-06	200	54	5	e5f876910bc8cb390d9b46a48d9b6d4d57235551
ToppCell	Children_(3_yrs)-Epithelial-basal_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ANOS1 PRSS12 LRP1B ITGB4	4.04e-05	158	54	4	d78e7e52657dc094430291fec07e9c298be9e584
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ANOS1 ATRNL1 CNTNAP2 PHETA2	4.45e-05	162	54	4	68c40d12689cc1b6c797e6e48173f0110f8144e4
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ANOS1 ATRNL1 CNTNAP2 PHETA2	4.45e-05	162	54	4	735fa3f77b31a4189e431d05c326403c18cbbffb
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-Late_airway_SMC\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	ADAMTS1 RASA4 TSGA10IP LRP1B	4.56e-05	163	54	4	1e8730d75cccf7292010683ab4e81a69d8e3bfa9
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	XYLT1 MTOR SCUBE3 CD163	4.67e-05	164	54	4	d2218d50e0e2d19f919dcb460b3840687c082810
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage_4\|390C / Donor, Lineage, Cell class and subclass (all cells)	WDR19 RASA4B PLAU CD163	5.37e-05	170	54	4	439167e44a1bd5ac8e1e457351dd202ec968db46
ToppCell	LPS-IL1RA-Epithelial_alveolar-Mes-like\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SEMA3F TRIM8 LRP1B ZNF239	5.49e-05	171	54	4	3ad4f138d9570500cfb4423a2be16bb7d1cacbf8
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	XYLT1 FAT4 ATRNL1 SPON1	5.49e-05	171	54	4	972fab891135bd755d5526cbc5a963200067b0a6
ToppCell	LPS-IL1RA-Epithelial_alveolar-Mes-like-AT2_Progenitor\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SEMA3F TRIM8 LRP1B ZNF239	5.49e-05	171	54	4	ca2775a17b5c339c480a963953b6fa2b0731f24d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	XYLT1 FAT4 ATRNL1 SPON1	5.49e-05	171	54	4	2a77ed79c6f2e700e789c80451a70ecb31639719
ToppCell	5'-Adult-LargeIntestine-Epithelial-neuro-epithelial-EECs\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TRMT9B DNAH17 SCUBE3 ZDHHC11	5.49e-05	171	54	4	dd37e1693a5cfc42e40992d504f92048a8038b52
ToppCell	Adult-Endothelial-endothelial_cell_of_bronchial_vessel\|Adult / Lineage, Cell type, age group and donor	ADAMTS1 ADAMTS9 LRP1B ITGB4	5.62e-05	172	54	4	ad4ffdb3fc0c560a9cbaa2bc048476cbc43e8fd6
ToppCell	Basal_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	XYLT1 SEMA3F LIG3 ITGB4	5.88e-05	174	54	4	a0060be3940043015dcc49a5157de5541aed24a1
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMTS1 SPON1 DNAH17 FRMD3	6.28e-05	177	54	4	bd602db857f37869ef76d14c05ef522c509f08ee
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	XYLT1 ADAMTS1 ATRNL1 SPON1	6.42e-05	178	54	4	d4ecb84e9b1f4ec49c519321156aa10f9bd34cce
ToppCell	normal_Pleural_Fluid-Myeloid_cells-mo-Mac\|normal_Pleural_Fluid / Location, Cell class and cell subclass	ANOS1 PSAP PLAU CD163	6.56e-05	179	54	4	cd3c58e044f5a38e815313a1636153d81a592fce
ToppCell	COVID-19-kidney-AQP1+SLC14A1+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SEMA3F ADAMTS1 ADAMTS9 ITGB4	6.56e-05	179	54	4	1ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCell	droplet-Limb_Muscle-Pre-Sort\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3F ADAMTS1 ADAMTS9 ITGB4	6.70e-05	180	54	4	af2bafcd1b2082629de3ea336711add01565c4c4
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRSS12 SPON1 ADAM22 FRMD3	6.70e-05	180	54	4	08ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma-4\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	ANOS1 SCUBE3 LOXL3 ADAM22	6.70e-05	180	54	4	886ebaf9cf8992e8dd13fca799a1d1a2a9ce73d8
ToppCell	facs-Bladder-nan-24m-Epithelial-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	XYLT1 FAT4 ADAMTS9 SPON1	6.70e-05	180	54	4	12537d8a569faa69f474284d2c201475722b8ca1
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3F ADAMTS1 ADAMTS9 ITGB4	6.70e-05	180	54	4	f29a995cf6e1a1836ed68b73258d9370bf3d4434
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADAMTS1 ADAMTS9 ATRNL1 SPON1	7.00e-05	182	54	4	ed6ae0fd8653f213fe29906a6a4e0729a62e1b75
ToppCell	5'-Adult-LymphNode-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SEMA3F ADAMTS9 RASA4 RASA4B	7.15e-05	183	54	4	a644258ba90acc62d571623e429d72ffc4b69203
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TRMT9B ADAMTS9 ITGB4 NOTCH1	7.15e-05	183	54	4	bc98df870de65aff6dab295c24cbc199c7f2aa15
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Degenerative_Connecting_Tubule_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PSAP SCUBE3 LRP1B ADAM22	7.30e-05	184	54	4	9690d4290e70f9bda889754ffb30b0af1f7cb94b
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS1 PRSS12 ATRNL1 ADAM22	7.45e-05	185	54	4	6712512100ccef456d2e2bd201d0987986c92ac9
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3F FAT4 ITGB4 FRMD3	7.45e-05	185	54	4	f98af3146ec2f44c30d31a662fb9c4fa3ca4f706
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADAMTS1 ADAMTS9 ATRNL1 SPON1	7.45e-05	185	54	4	e58a009aaf342be019a909747b1895d5987d4daf
ToppCell	Endothelial-A-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	SEMA3F FAT4 ADAMTS1 ITGB4	7.45e-05	185	54	4	dee0b7ba2f338f0979d2306aedf52ac35a36b60c
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SEMA3F FAT4 ADAMTS1 ITGB4	7.45e-05	185	54	4	a7ae76058b2082020cadec49d63b9f4e24d21734
ToppCell	Endothelial-A-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	SEMA3F ADAMTS1 ADAMTS9 FRMD3	7.61e-05	186	54	4	796cbae2a417502aaf0891fc9c382bbfd88967fe
ToppCell	COVID-19-Heart-EC_2\|Heart / Disease (COVID-19 only), tissue and cell type	FAT4 ADAMTS1 ADAMTS9 ITGB4	7.77e-05	187	54	4	40ffc06a3e3251d9b12da390210d3e045af7537a
ToppCell	367C-Endothelial_cells-Endothelial-D\|367C / Donor, Lineage, Cell class and subclass (all cells)	SEMA3F ADAMTS1 ADAMTS9 ITGB4	7.77e-05	187	54	4	1342bc614bc4045263c2eb0a535a1dd6c64e7abe
ToppCell	367C-Endothelial_cells-Endothelial-D-\|367C / Donor, Lineage, Cell class and subclass (all cells)	SEMA3F ADAMTS1 ADAMTS9 ITGB4	7.77e-05	187	54	4	7aa206262b14b9f2aaa99e59da38b96c3594d2c9
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS1 ADAMTS9 SPON1 ITGB4	7.77e-05	187	54	4	9aa411ae9b5a923378a5daebb8bb2fc2613f2510
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Endothelial-endothelial_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3F ADAMTS9 RASA4 NOTCH1	8.10e-05	189	54	4	476226787c8ea0c9834a6f4c99ac7091cc20a455
ToppCell	Mesenchymal-myofibroblast_cell\|World / Lineage, Cell type, age group and donor	FAT4 ADAMTS1 ATRNL1 SPON1	8.10e-05	189	54	4	44e37f88137bb249933eb615235b2cf2ae7f3925
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TRMT9B ADAMTS1 PLAU LRP1B	8.10e-05	189	54	4	8c8ca3b30d9be6c854615459a7bfba82b427c8bc
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Endothelial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3F ADAMTS9 RASA4 NOTCH1	8.10e-05	189	54	4	3fe69bad6427e41b8d2dae450828cc21e9c3b3ad
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TRMT9B ADAMTS9 ITGB4 NOTCH1	8.10e-05	189	54	4	55a1776a4ce049959b3f13a43744c7314bc1f00a
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Endothelial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3F ADAMTS9 RASA4 NOTCH1	8.10e-05	189	54	4	d9c2adbbe3e40eb8d57200b6411533e6685ea0d2
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TRMT9B ADAMTS1 PLAU LRP1B	8.10e-05	189	54	4	5d902a4660a27548764bf04c6de152b565da835c
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 ATRNL1 SPON1 ADAM22	8.10e-05	189	54	4	c734e5693808a0333139e87bd5be2597a9252afe
ToppCell	ASK428-Epithelial-Transformed_epithelium\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	SEMA3F ADAMTS1 ADAMTS9 ZNF239	8.10e-05	189	54	4	87189275234b5d59484c58acbb14a09903f2b578
ToppCell	IPF-Epithelial-Basal\|Epithelial / Disease state, Lineage and Cell class	ANOS1 PLAU ITGB4 NOTCH1	8.26e-05	190	54	4	4f15842b424eefadbfe451875e517cf70e29607f
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ADAMTS1 ATRNL1 TSGA10IP LRP1B	8.26e-05	190	54	4	938d1f66094b1c94606e0d40213a39e5112f3322
ToppCell	COVID-19-lung-Vein_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SEMA3F FAT4 ADAMTS9 ITGB4	8.26e-05	190	54	4	1caeaef78326734c1e31a0c4739190d5c5a77b9e
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SEMA3F FAT4 ADAMTS1 ITGB4	8.26e-05	190	54	4	f6c38d197fd9d69a4f97cb2e72cd4747984c1a86
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 ATRNL1 SPON1 ADAM22	8.26e-05	190	54	4	445952b70abffadb6ccc1ed4bbf61a88b06b73b3
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 ATRNL1 SPON1 ADAM22	8.26e-05	190	54	4	2e592323085ba9c019d678ac2a784462ab470ed9
ToppCell	Endothelial-A-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	SEMA3F FAT4 ADAMTS1 ADAMTS9	8.43e-05	191	54	4	f702dfe88a9b04091dae87df61b2b4f43525f86a
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 ATRNL1 SPON1 ADAM22	8.43e-05	191	54	4	cb0aee740b08f7d5fdd2717ecf7429043b277ae7
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 ATRNL1 SPON1 ADAM22	8.43e-05	191	54	4	c54c420a94dc749ebc67fc64c5614663f4b9798d
ToppCell	droplet-Mammary_Gland-nan-18m-Endothelial-endothelial_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3F ADAMTS1 ADAMTS9 RASA4	8.60e-05	192	54	4	945153c41dde6e90d103206955e1707b54eb0665
ToppCell	droplet-Mammary_Gland-nan-18m-Endothelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3F ADAMTS1 ADAMTS9 RASA4	8.60e-05	192	54	4	6ab50579c63f31ca2cd41063a99b129f11c07510
ToppCell	facs-Pancreas-Exocrine-3m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS1 ADAMTS9 SPON1 ITGB4	8.78e-05	193	54	4	c3161a14a40323a58aa202c8a1d6ea0e9c2b9814
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	XYLT1 ADAMTS1 ATRNL1 SPON1	8.78e-05	193	54	4	5b602b1702283184bd3943c2a6f2290b7c37e407
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	XYLT1 ADAMTS1 ATRNL1 SPON1	8.78e-05	193	54	4	c8c21eee8c6c086dc2faf416669cd4a002870fbe
ToppCell	droplet-Mammary_Gland-nan-18m-Endothelial-endothelial_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3F ADAMTS1 ADAMTS9 RASA4	9.13e-05	195	54	4	4db30b3bc65c25626f828cd4f867f20c71809898
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SEMA3F ADAMTS1 ADAMTS9 ITGB4	9.13e-05	195	54	4	023e3c97dd3696d74f002ff8da0c04d876c82aef
ToppCell	5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SEMA3F ADAMTS9 RASA4 PLAU	9.32e-05	196	54	4	c5fe470f11ee4962bcfb30cddfd8c078af5b1222
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	XYLT1 FAT4 ATRNL1 SPON1	9.32e-05	196	54	4	a12dd986df65c36f248cf10815c3b8b6238613b0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	XYLT1 ADAMTS1 ATRNL1 SPON1	9.32e-05	196	54	4	3a6c942e2907aa07b5e12dbf9019d18f7bfca507
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	XYLT1 FAT4 ATRNL1 SPON1	9.32e-05	196	54	4	3e6803587d8566fd08cb8b290be3b6461743d79c
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADAMTS1 ADAMTS9 RASA4 RASA4B	9.32e-05	196	54	4	5609b2d93172a488b35d854298a3a4e504e17e28
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	XYLT1 ADAMTS1 ATRNL1 SPON1	9.32e-05	196	54	4	bba88e91cd3e3a6f5a9b443e3a4da33c5b455e70
ToppCell	ASK454-Endothelial-Endothelium\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	SEMA3F FAT4 ADAMTS1 ADAMTS9	9.32e-05	196	54	4	2b777a2026b56839112fd179f2db482c49f4594a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	XYLT1 ADAMTS1 ATRNL1 SPON1	9.50e-05	197	54	4	09946ee8dfb15a2a32da06e5b331f3277ee934f4
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SEMA3F ADAMTS1 ADAMTS9 ITGB4	9.50e-05	197	54	4	ad4a3b5da2190be9495382a2952991e1de9f190d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	XYLT1 FAT4 ATRNL1 SPON1	9.50e-05	197	54	4	85a8f1d18e0dd1d31341f5131eecd217553bf042
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	XYLT1 FAT4 ATRNL1 SPON1	9.50e-05	197	54	4	9b480f9c799a244bfee64487abd8a1bf07c9a3a2
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	XYLT1 FAT4 ATRNL1 SPON1	9.50e-05	197	54	4	e8e3ba791dfaa0fab35e0329a5e34376f9ee6143
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	XYLT1 ADAMTS1 ATRNL1 SPON1	9.69e-05	198	54	4	79576525a10ed3e3a9d1608077cd16ecda23376f
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NETO1 ATRNL1 CNTNAP2 ADAM22	9.69e-05	198	54	4	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	XYLT1 FAT4 ATRNL1 SPON1	9.69e-05	198	54	4	a860246bcea847249a78fd2e86ed8e04371060db
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NETO1 ATRNL1 CNTNAP2 ADAM22	9.69e-05	198	54	4	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	distal-3-Endothelial-Bronchial_Vessel_1\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ADAMTS1 ADAMTS9 RASA4 ITGB4	9.69e-05	198	54	4	00fdee373eaa43c9ce897f2ba2ecbe94cedea93a
ToppCell	Fetal_29-31_weeks\|World / Lineage, Cell type, age group and donor	FAT4 ADAMTS1 ADAMTS9 CNTNAP2	9.88e-05	199	54	4	5b9d355795dd03a22f0961dfd143425c367a4654
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-Early_airway_SMC_2\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	ANOS1 ADAMTS1 TSGA10IP LRP1B	9.88e-05	199	54	4	a207b4891881149d4c50721310690fd794157723
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ADAMTS1 PRSS12 ATRNL1 ADAM22	9.88e-05	199	54	4	e9820d5fb4e8b46973c4c50ac5db8fb4a1bf603b
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Vein\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SEMA3F ADAMTS9 RASA4 ITGB4	9.88e-05	199	54	4	cfb624c7728046fc7f3ef071f57e4d7b013f3fef
ToppCell	ILEUM-inflamed-(7)_ACKR1+_endothelial_cells\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	SEMA3F ADAMTS1 ADAMTS9 ITGB4	9.88e-05	199	54	4	5c799115a6e95bcd896e4ad10bd272705c9a4e2c
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3F ADAMTS9 SCUBE3 ADAM22	9.88e-05	199	54	4	3cd6383c50ce342fe5c175e2e50784d634a90e80
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PSAP PLAU LOXL3 CD163	1.01e-04	200	54	4	78d75d381cb2b9a4c9eb7c32a07b014eaee39195
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ADAMTS1 PRSS12 ATRNL1 ADAM22	1.01e-04	200	54	4	08bf8c00eee6468215edb3611296bfc8784c4d56
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_venous\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SEMA3F ADAMTS1 ADAMTS9 ITGB4	1.01e-04	200	54	4	84e145619a500530f42ed0fe72468ae95f4cbf1e
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_only / Treatment groups by lineage, cell group, cell type	ADAMTS1 PRSS12 ATRNL1 ADAM22	1.01e-04	200	54	4	a9ff3210127000b3dd9e97136163c98c2b0817d7
Drug	Lobelanidine hydrochloride [6112-86-3]; Up 200; 10.6uM; MCF7; HT_HG-U133A	TRMT9B ATRN PRSS12 ATRNL1 PLAU ADAM22	5.85e-06	198	52	6	5500_UP
Drug	Fenoterol hydrobromide [1944-12-3]; Up 200; 10.4uM; PC3; HT_HG-U133A	ZCCHC4 LIG3 ADAMTS1 ADAM22 WDTC1	5.92e-05	182	52	5	6331_UP
Drug	acarbose	PSAP RNGTT NETO1 CRAMP1	6.34e-05	94	52	4	CID000041774
Drug	Rapamycin; Up 200; 0.1uM; MCF7; HT_HG-U133A	WDR19 TRMT9B SEMA3F ADAM22 WDTC1	6.73e-05	187	52	5	5204_UP
Drug	Triflupromazine hydrochloride [1098-60-8]; Up 200; 10.2uM; PC3; HT_HG-U133A	LIG3 ADAMTS1 CHD4 ITGB4 WDTC1	7.44e-05	191	52	5	1813_UP
Drug	Doxorubicin hydrochloride [25316-40-9]; Up 200; 6.8uM; MCF7; HT_HG-U133A	PSAP ATRNL1 CNTNAP2 ADAM22 WDTC1	7.44e-05	191	52	5	3291_UP
Drug	Cimetidine [51481-61-9]; Down 200; 15.8uM; MCF7; HT_HG-U133A	SEMA3F ATRN ITGB4 NOTCH1 WDTC1	7.82e-05	193	52	5	1464_DN
Drug	Equilin [474-86-2]; Down 200; 15uM; MCF7; HT_HG-U133A	CNTNAP2 PLAU ITGB4 ADAM22 WDTC1	8.01e-05	194	52	5	5255_DN
Drug	Acetylsalicylsalicylic acid [530-75-6]; Down 200; 13.4uM; MCF7; HT_HG-U133A	SEMA3F LIG3 RNF216 PLAU WDTC1	8.01e-05	194	52	5	6778_DN
Drug	Halcinonide [3093-35-4]; Down 200; 8.8uM; HL60; HT_HG-U133A	LIG3 MTOR RNF216 PLAU NOTCH1	8.01e-05	194	52	5	2185_DN
Drug	Naproxen [22204-53-1]; Down 200; 17.4uM; MCF7; HT_HG-U133A	DNAH17 CNTNAP2 PLAU ADAM22 WDTC1	8.01e-05	194	52	5	5457_DN
Drug	Acetylsalicylsalicylic acid [530-75-6]; Down 200; 13.4uM; MCF7; HT_HG-U133A	SEMA3F MTOR PLAU ADAM22 WDTC1	8.21e-05	195	52	5	2223_DN
Drug	Antazoline hydrochloride [2508-72-7]; Down 200; 13.2uM; MCF7; HT_HG-U133A	SEMA3F ZCCHC4 ATRNL1 ITGB4 WDTC1	8.21e-05	195	52	5	3173_DN
Drug	Chlorambucil [305-03-3]; Up 200; 13.2uM; PC3; HT_HG-U133A	TRMT9B ZCCHC4 PRSS12 SPON1 CNTNAP2	8.41e-05	196	52	5	4523_UP
Drug	Solanine alpha [20562-02-1]; Down 200; 4.6uM; MCF7; HT_HG-U133A	WDR19 SEMA3F RNGTT ITGB4 ADAM22	8.41e-05	196	52	5	4166_DN
Drug	CP-944629 [668990-94-1]; Up 200; 10uM; PC3; HT_HG-U133A	SEMA3F LIG3 CNTNAP2 RNF216 ITGB4	8.41e-05	196	52	5	7502_UP
Drug	Dubinidine [22964-77-8]; Up 200; 14.6uM; MCF7; HT_HG-U133A	TRMT9B LIG3 ADAMTS9 ATRNL1 ADAM22	8.61e-05	197	52	5	6250_UP
Drug	Sulfamethoxazole [723-46-6]; Up 200; 15.8uM; MCF7; HT_HG-U133A	TRMT9B ZCCHC4 RNGTT ATRNL1 ADAM22	8.61e-05	197	52	5	4690_UP
Drug	Bromopride [4093-35-0]; Up 200; 11.6uM; MCF7; HT_HG-U133A	TRMT9B ADAMTS9 CNTNAP2 ADAM22 WDTC1	8.82e-05	198	52	5	6037_UP
Drug	Probenecid [57-66-9]; Down 200; 14uM; PC3; HT_HG-U133A	SEMA3F LIG3 CNTNAP2 ITGB4 WDTC1	8.82e-05	198	52	5	4185_DN
Drug	Thonzonium bromide [553-08-2]; Down 200; 6.8uM; MCF7; HT_HG-U133A	SEMA3F LIG3 RNGTT ADAM22 WDTC1	8.82e-05	198	52	5	5678_DN
Drug	Epirizole [18694-40-1]; Up 200; 17uM; MCF7; HT_HG-U133A	SPON1 PLAU TRIM21 ADAM22 WDTC1	9.03e-05	199	52	5	5995_UP
Drug	(-) -Levobunolol hydrochloride [27912-14-7]; Down 200; 12.2uM; PC3; HT_HG-U133A	TRMT9B ATRN LIG3 ADAMTS1 ADAM22	9.03e-05	199	52	5	4016_DN
Drug	Brinzolamide [138890-62-7]; Up 200; 10.4uM; MCF7; HT_HG-U133A	ZCCHC4 LIG3 SPON1 DNAH17 CNTNAP2	9.03e-05	199	52	5	3230_UP
Drug	Meclocycline sulfosalicylate [73816-42-9]; Up 200; 5.8uM; MCF7; HT_HG-U133A	SEMA3F LIG3 SPON1 PLAU WDTC1	9.03e-05	199	52	5	4982_UP
Disease	Nephronophthisis, familial juvenile	WDR19 ADAMTS9	6.12e-05	7	51	2	C1855681
Disease	congenital heart disease	PRSS12 LRP1B TENT5D	1.48e-04	59	51	3	EFO_0005207
Disease	transient cerebral ischemia (biomarker_via_orthology)	ADAMTS1 MTOR PLAU NOTCH1	1.59e-04	157	51	4	DOID:224 (biomarker_via_orthology)
Disease	Internal Carotid Artery Diseases	PLAU CD163	1.59e-04	11	51	2	C0750986
Disease	Arterial Diseases, Common Carotid	PLAU CD163	1.59e-04	11	51	2	C0750987
Disease	Carotid Atherosclerosis	PLAU CD163	1.59e-04	11	51	2	C0577631
Disease	External Carotid Artery Diseases	PLAU CD163	1.59e-04	11	51	2	C0600178
Disease	Carotid Artery Diseases	PLAU CD163	1.59e-04	11	51	2	C0007273
Disease	Neoplasm of uncertain or unknown behavior of bladder	MTOR NOTCH1	3.03e-04	15	51	2	C0496930
Disease	Benign neoplasm of bladder	MTOR NOTCH1	3.03e-04	15	51	2	C0154017
Disease	Carcinoma in situ of bladder	MTOR NOTCH1	3.03e-04	15	51	2	C0154091
Disease	Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	MTOR NOTCH1	3.46e-04	16	51	2	C0334634
Disease	information processing speed	ATRNL1 LRP1B ZNF239	4.35e-04	85	51	3	EFO_0004363
Disease	Carcinoma of bladder	MTOR NOTCH1	4.40e-04	18	51	2	C0699885
Disease	disease free survival	TRMT9B CNTNAP2	4.40e-04	18	51	2	EFO_0000409
Disease	obesity (implicated_via_orthology)	FAT4 ADAMTS9 NOTCH1 WDTC1	5.24e-04	215	51	4	DOID:9970 (implicated_via_orthology)
Disease	status epilepticus (implicated_via_orthology)	MTOR PLAU	6.02e-04	21	51	2	DOID:1824 (implicated_via_orthology)
Disease	sciatic neuropathy (implicated_via_orthology)	MTOR PLAU	7.24e-04	23	51	2	DOID:11446 (implicated_via_orthology)
Disease	peptic ulcer disease, Peptic ulcer and gastro-oesophageal reflux disease (GORD) drug use measurement, gastroesophageal reflux disease	SEMA3F CNTNAP2	7.89e-04	24	51	2	EFO_0003948, EFO_0009923, MONDO_0004247
Disease	Early Pregnancy Loss	ITGB4 CD163 FETUB	8.98e-04	109	51	3	C3830362
Disease	Miscarriage	ITGB4 CD163 FETUB	8.98e-04	109	51	3	C4552766
Disease	Spontaneous abortion	ITGB4 CD163 FETUB	8.98e-04	109	51	3	C0000786
Disease	Abortion, Tubal	ITGB4 CD163 FETUB	8.98e-04	109	51	3	C0000822
Disease	Glioblastoma Multiforme	GUCY2F MTOR NOTCH1	9.46e-04	111	51	3	C1621958
Disease	Carcinoma, Granular Cell	FAT4 MTOR PLAU	1.07e-03	116	51	3	C0205644
Disease	Adenocarcinoma, Tubular	FAT4 MTOR PLAU	1.07e-03	116	51	3	C0205645
Disease	Adenocarcinoma, Oxyphilic	FAT4 MTOR PLAU	1.07e-03	116	51	3	C0205642
Disease	Carcinoma, Cribriform	FAT4 MTOR PLAU	1.07e-03	116	51	3	C0205643
Disease	Adenocarcinoma, Basal Cell	FAT4 MTOR PLAU	1.07e-03	116	51	3	C0205641
Disease	Adenocarcinoma	FAT4 MTOR PLAU	1.07e-03	116	51	3	C0001418
Disease	intellectual disability (is_implicated_in)	PRSS12 CNTNAP2	1.24e-03	30	51	2	DOID:1059 (is_implicated_in)
Disease	Squamous cell carcinoma of lung	GUCY2F NOTCH1	1.41e-03	32	51	2	C0149782
Disease	IGA Glomerulonephritis	PLAU CD163	1.59e-03	34	51	2	C0017661
Disease	cervical cancer	MTOR NOTCH1	1.59e-03	34	51	2	C4048328
Disease	Uterine Cervical Neoplasm	MTOR NOTCH1	1.68e-03	35	51	2	C0007873

Protein segments in the cluster

Peptide	Gene	Start	Entry
WSWQQCHCKEGLTGK	FAT4	4181	Q6V0I7
GNCGKDKDTWIQCNK	ADAM22	581	Q9P0K1
KWSCCHQKEKTGQGC	RASA4	691	O43374
QKSVQCGTWTKHAEG	NETO1	36	Q8TDF5
KWSCCHQKEKTGQGC	RASA4B	691	C9J798
EGKWCINGKCVNKTD	ADAMTS1	536	Q9UHI8
NGSLVWCQNHKQCSK	ANOS1	71	P23352
IEQCPKSSWGEHNCG	PRSS12	356	P56730
CDKGWSAHNSHVVCG	LOXL3	201	P58215
SPCKNGGKCWQTHTQ	NOTCH1	1066	P46531
LCCTGQWEDAQKLQH	HOGA1	256	Q86XE5
SNGQCIPAKWKCDGH	LRP1B	3561	Q9NZR2
GEVQQKCHQFCGWEG	RNGTT	251	O60942
NWKGEACDIPHCTDN	ATRN	276	O75882
EGANVCRHGKLCWLQ	EXD1	106	Q8NHP7
TDCHVLRKKAWQDCG	FETUB	91	Q9UGM5
SFEPQKCWKNNVGHC	DEFB125	21	Q8N687
QKWCTVTKCAGGHDD	LIG3	721	P49916
SCVQCQAWGTGEKKG	ITGB4	631	P16144
KNLSWGLNCKNIGHE	CCDC105	441	Q8IYK2
PAACKHLWKCGVENQ	FRMD3	291	A2A2Y4
LWCNNVNGVHKGCRT	ADAMTS9	541	Q9P2N4
VTCGKGHKHRQVWCQ	ADAMTS9	1066	Q9P2N4
KVQCFHCGGGLANWK	BIRC8	36	Q96P09
KCENTKVFHGWLQCD	DNAH17	1051	Q9UFH2
KCWFAEGKICHGGID	GUCY2F	451	P51841
FCTVHWQEGGRCKQS	CRAMP1	421	Q96RY5
NAGPGIKCVWNKNHC	ATRNL1	626	Q5VV63
NHCEHGGKCSQTWDS	CNTNAP2	561	Q9UHC6
LICNGNESALWNCKH	CD163	226	Q86VB7
EGKWSCPHCEKEGIQ	CHD4	406	Q14839
HWNGKDCTEPLKCQG	SCUBE3	391	Q8IX30
ALGEWGQLHQQCCEK	MTOR	1486	P42345
EAHGCCWKTEAQNLK	TSGA10IP	156	Q3SY00
QWSECNKSCGKGHVI	SPON1	676	Q9HCB6
SNIHWCNCPKKFGGQ	PLAU	46	P00749
LNDDGGHCCLVNKWS	SEMA3F	301	Q13275
VQKLVKVCNGHDCWS	TENT5D	131	Q8NEK8
ETCRKCQGLWKEHNG	RNF216	631	Q9NWF9
CQGLWKEHNGLTCEE	RNF216	636	Q9NWF9
GKHTKRITCGCWNAE	WDR19	136	Q8NEZ3
SQGNIHCSDKGSWCE	PLA2G2D	91	Q9UNK4
HSGCVNCLEWNEKGD	WDTC1	46	Q8N5D0
AAQEKDKGVCQGWHC	LINC00173	46	Q6ZV60
CWQKRAQGSHSKCEE	PHETA2	241	Q6ICB4
KHIVDWCGCSPNDFK	XYLT1	566	Q86Y38
DCGAVKHCLQTVWNK	PSAP	41	P07602
DGKALCWVCAQSRKH	TRIM21	106	P19474
KCVSGFDHHCKWINN	ZDHHC11	146	Q9H8X9
MCGKNCNSEKQWQGH	ZC3H7A	861	Q8IWR0
LCNSCTSKDGRKWNH	ZCCHC4	396	Q9H5U6
QGFSGQLCCWLTKEH	ZNF843	96	Q8N446
SGNDHGNWCIIAEKK	TRMT9B	436	Q9P272
DCNCKDIHGWKSQVV	ZNF239	151	Q16600
KCVSGFDHHCKWINN	ZDHHC11B	146	P0C7U3
KHNFCRGCIGEAWAK	TRIM8	31	Q9BZR9
WHQDKEGLCGQCASL	USP6	251	P35125